Category Archives: Tms

Question: Are there any advances in treatment for medication-resistant depression?

Answer: In 2008, the FDA cleared the NeuroStar TMS brain-stimulating device for treating adults with treatment-resistant depression.

Transcranial Magnetic Stimulation (TMS) or repetitive TMS (rTMS) is a non-invasive, non-drug medical therapy that delivers highly focused, MRI-strength magnetic pulses to stimulate nerve cells in a localized part of the brain. Research shows this can reverse changes in brain cell activity and brain chemicals that occur in depression and in other psychiatric and neurological disorders.

Clinical studies have shown some benefit for chronic pain conditions such as fibromyalgia, and for addictions, tinnitus and other disorders. Other studies have shown short-term improvement in some symptoms of Alzheimers disease, Parkinsons disease, and post-stroke speech disorders and paralysis. In Europe, TMS has received CE approval for Chronic Neuropathic Pain, among other conditions.

A typical TMS session lasts 30 to 60 minutes and does not require anesthesia. An electromagnetic coil with about the same strength as that of an MRI scan is held against the forehead near an area of the brain that is thought to be involved in mood regulation. Then, short electromagnetic pulses are administered through the coil. The magnetic pulse easily passes through the skull and causes small electrical currents that stimulate nerve cells in the targeted brain region. Because this type of pulse generally does not reach farther than 2 inches into the brain, we can select which parts of the brain will be affected and which will not.

TMS is a safe treatment and does not have the potential for side effects of medications such as sedation, constipation, weight gain and addiction problems. Some patients experience mild head pain when starting the treatment and there is a very small risk of causing a seizure. Patients with seizures, pacemakers, implants, strokes, or tumors would need to be treated with caution.

TMS is one of a new class of non-invasive brain treatments being developed for neurological disorders. Other non-invasive devices include Transcranial Direct Current Stimulation (tDCS) and Transcranial Focused Ultrasound. Both Neurostar TMS and tDCS are available at the Brainstim Brain Stimulation Center.

Robert J. Friedman, M.D. is triple board-certified in Neurology, Pain Management, and Neuromuscular Medicine by the American Board of Psychiatry & Neurology (ABPN.) Dr. Friedman completed his education / training at Dartmouth College, University of Pittsburgh School of Medicine, Allegheny General Hospital, Dartmouth-Hitchcock Medical Center, Johns Hopkins University and the Florida Pain Clinic, and in Transcranial Magnetic Stimulation (TMS) at Harvard Medical School.

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Headache & Pain Center of Palm Beach

875 Military Trail Suite 208 Jupiter, Florida 33458

7408 Lake Worth Road Wellington, Florida 33467

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A new drug-free way to treat depression and pain - Palm Beach Post

InMotion Global, Inc. announced that AscendTMS has released a new commission and branch split management system available for TMS software.

The new module is provided as an included feature of the Premium AscendTMS subscription. It allows carriers and freight brokers to setup and manage a variety of sales commission and branch split programs, along with full commission overrides on a load-by-load basis, the company noted.

Tim Higham, president and CEO of InMotion Global, Inc. said, Commissions and sales incentives are the life-blood of all successful carriers and freight brokers. So, we designed our new commissions system to let the sales team monitor their own successes in real-time. Any commissioned sales representative can see exactly what has been paid, what is owed, and what their future commissions are expected to be. Better still, sales managers dont need to be asked to run commission reports, the sales reps can do it themselves any time they wish.

Higham continued, Whether you have one sales person or one thousand, this new AscendTMS feature gives you a happier and more productive sales force, which translates into more revenue and more profit. Thats why AscendTMS is the fastest-growing TMS in the world today. Never again will sales reps question their commissions or their branch split. AscendTMS does everything and its perfectly accurate every single time.

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AscendTMS launches commission system for TMS Software - Fleet Owner

Shares ofTargeted Microwave Solutions Inc. (TMS.V) have seen the needle move0.00% or 0.00 in the most recent session. TheTSXV listed companysaw a recent bid of0.05 on56000 volume.

Investing in the stock market may include having to keep emotions in check. When things get crazy, investors may be forced with tough decisions. Being able to stay away from impulsive decisions may help when the time comes to tweak the portfolio. Having the proper discipline and market perspective may also be a highly desirable trait for a successful trader. Investors who are able to practice discipline may be able to avoid emotional trading pitfalls in the future. Even highly experienced investors may have to someday make the difficult decisions in order to keep the portfolio strong. Figuring out what works and what doesnt may take many years of trial and error. Learning to filter through the daily noise can be a big asset when trying to focus on the particularly important information.

Now letstake a look at how the fundamentals are stacking up for Targeted Microwave Solutions Inc. (TMS.V). Fundamental analysis takes into consideration market, industry and stock conditions to help determine if the shares are correctly valued. Targeted Microwave Solutions Inc. currently has a yearly EPS of -0.11. This number is derived from the total net income divided by shares outstanding. In other words, EPS reveals how profitable a company is on a share owner basis.

Whichever way the markets go, investors will need to watch which companies are hitting their marks on the earnings front. Investors may closely follow sell-side analyst estimates. It is important to remember that analyst projections are just that, projections. Following analyst expectations can provide a good glimpse into company actions, but strictly following what the analysts are saying may lead to difficulty in the future. Doing careful and extensive individual stock research may provide the investor with a more robust scope with which to successfully trade the market.

Another key indicator that can help investors determine if a stock might be a quality investment is the Return on Equity or ROE. Targeted Microwave Solutions Inc. (TMS.V) currently has Return on Equity of -124.73. ROE is a ratio that measures profits generated from the investments received from shareholders.

In other words, the ratio reveals how effective the firm is at turning shareholder investment into company profits. A company with high ROE typically reflects well on management and how well a company is run at a high level. A firm with a lower ROE might encourage potential investors to dig further to see why profits arent being generated from shareholder money.

Another ratio we can look at is the Return on Invested Capital or more commonly referred to as ROIC. Targeted Microwave Solutions Inc. (TMS.V) has a current ROIC of -108.54. ROIC is calculated by dividing Net Income Dividends by Total Capital Invested.

Similar to ROE, ROIC measures how effectively company management is using invested capital to generate company income. A high ROIC number typically reflects positively on company management while a low number typically reflects the opposite.

Turning to Return on Assets or ROA, Targeted Microwave Solutions Inc. (TMS.V) has a current ROA of -95.05. This is a profitability ratio that measures net income generated from total company assets during a given period. This ratio reveals how quick a company can turn its assets into profits. In other words, the ratio provides insight into the profitability of a firms assets. The ratio is calculated by dividing total net income by the average total assets.

A higher ROA compared to peers in the same industry, would suggest that company management is able to effectively generate profits from their assets. Similar to the other ratios, a lower number might raise red flags about managements ability when compared to other companies in a similar sector.

Investors are usually scouring the markets for that next great stock pick. Locating that special winner to jumpstart the portfolio may involve lots of diligent hard work. Filing through the massive amounts of data regarding public companies can be an overwhelming task. Many successful investors will approach the equity markets from various sides. This may include keeping a close eye on the fundamentals as well as the technical data. This may also include following sell-side analyst opinions and tracking what the big money institutions are buying or selling.

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Active Runner in Focus: Targeted Microwave Solutions Inc. (TMS.V) - Stock Rover

CHATTANOOGA, TN (WRCB) -

Each year American's spend billions on antidepressants, but studies show they can be ineffective in up to 40 percent of all patients. Bob Holmes was one of them.

Bob Holmes says "They tried to adjust my medication, but the medication had side effects that weren't desirable."

Holmes is among the 16-million people in the U.S. who suffer major depressive episodes each year. Thatnumberincreased 18-percent over the last decade, which is why some doctors are taking a different approach.

Doctors are beaming magnetic pulses deep inside patients' brains to change the way depression symptoms are perceived.

Dr. Andrew Leuchter, UCLA Health says, "We are used to thinking of the brain as a chemical organ, but, it's also an electrical organ."

Dr. Ian Cook, UCLA Medical says, "It's called Transcranial Magnetic Stimulation or T-M-S. It's currently F-D-A approved only to treat depression, but doctors say it may prove helpful in a wide range of conditions, by rewiring a network of signals in the brain."

Doctors tell us that T-M-S can feel a bit uncomfortable at first, but many patients quickly get used to it and report substantial relief from their symptoms of depression within a few weeks.

Dr. Leuchter says, "What TMS is doing is changing how thenetwork functions, really rebooting the network to improve symptoms of mood, anxiety, and chronic pain."

Which may be why many patients treated for depression also say it helps relieve their pain. Raising provocative questions about whether T-M-S could one day become a viable alternative to opioids.

Dr. Ian Cook says, "This is really a transformative kind of therapy, but in medicine there's always the wish to do better, to help more people than what we do now."

But for now, it's made a dramatic difference in Bob's depression.

Bob Holmes says, "It provided that kind of jolt to get my brain to start work again, normally."

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Rewiring the brain to treat depression - WRCB-TV

| July 05, 2017

Indra said it replatformed its Travel Management Suite (TMS) onto SAPs cloud platform S/4HANA. It allows operating as a real-time enterprise with a single view of each guest. TMS will provide global, multi-property enterprises a single source of truth and visibility. SAP S/4HANA is an in-memory, fast relational database management system and it provides a platform that enables accelerated innovation and predictive experiences for hospitality. SAP S/4HANA is an intelligent ERP suite designed specifically for in-memory computing. It is the digital core that connects a hotel enterprise with customers, business networks, the Internet of things, big data, and more. Through this migration, Indra is capable of enabling the worlds largest and most complex hotel enterprises to take control and run a live business with Indras TMS solutions on SAP S/4HANA. With SAP S/4Hana, Indra will offer hotel enterprises the ability to:

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Indra to Replatform Its Leading TMS Solutions for Hotels Onto SAP S ... - Hospitality Technology

Sound of the summer: Test Match Specials Michael Vaughan and Jonathan Agnew. Photograph: Gareth Copley/Getty Images

It is 19 years since BBC television ceased broadcasting live Test cricket and 12 since Channel 4 drew stumps on its own free-to-air coverage. Since then, Sky has had the monopoly of rights to what was once the national summer game. This will change a bit in 2020, when the BBC will start showing highlights, and some live T20 games, with Sky retaining the bulk of the rights.

Yet for many, free-to-air cricket coverage is now synonymous with radios Test Match Special. On Thursday, as Test cricket resumes for the first time in this English summer, TMS marks its 60th year of ball-by-ball radio commentaries. This deserves salute from the paper of John Arlott, even while recognising that TMS is a Marmite taste that some adore and others dislike.

Many are devoted to TMSs gentle rhythms in spite of the male public school tone that still lingers. Others want it to converse better with todays Britain. The tension between tradition and innovation will always shape responses to TMS and cricket itself.

In a Wisden survey of TMSs role in the game, Matthew Engel this year highlighted an important truth. While televised sports relentless underlying dogma, especially in Skys treatment, is always that this is thrilling and it really matters, he wrote, radios values are subtler. On radio, there is a tacit pact with the listener, who will be registering the cricket as an agreeable extra in their own daily routine. Exactly so. Just as there is more to life than politics, so there is also more to life than cricket. But its good to welcome TMS back for the summer.

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The Guardian view on Test Match Special: 60 years of tacit pleasure - The Guardian

Charlotte Observer (blog)

On the radio, he brings life to the party. Off it, mental illness nearly killed him. Charlotte Observer (blog) I finally start my TMS Therapy (transcranial magnetic stimulation) for my major depression and anxiety tomorrow...here's hoping all goes well and that every time my wife Mary turns on the microwave, I don't piss my pants and forget who I am for about ...

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On the radio, he brings life to the party. Off it, mental illness nearly killed him. - Charlotte Observer (blog)

Saturday night comedian and pop culture commentator Stevie Ryan lost a long and hard fought battle with depression. Stevie has been very open and public about her quest for depression treatment, peppering in tweets about 3-hour-long talk therapy sessions and Instagram posts about transcranial magnetic stimulation (TMS) treatments (above) along with her scathing humor about pop culture and reality stars like the Teen Mom cast and the Kardashians.

Three months ago Stevie Ryan launched a mental health podcast called Mentally Ch(ill) with fellow comedian Kristen Carney. The episodes, which are embedded below, involve frank and humorous about all aspects of living with depression and seeking treatment.

In podcast posted on May 23, 2017, Ryan talks about embarking a month-long set of every day TMS (transcranial magnetic stimulation) treatments. As pictured above, the treatments involve her sitting there with a giant magnet on her brain. According to the Mayo Clinic website, TMS is often used when most other depression treatments have been ineffective.

The magnet is supposed to deliver a pulse that stimulates nerve cells in parts of the brain that regulate mood. I just have to sit there for a half-hour while this magnet just pounds on my head, Ryan explained on the podcast. It will move your eyebrows a little.

She went on to say that they fitted her for her personal device by testing to see which part of the brain they could stimulate that would make your fingers and hands start twitching. They told her they could also do that to her legs. Shed only had one real treatment before she already started to see a difference in her mood in the morning. Usually, Ryan said she cried every single morning when she woke up, but the day after her first TMS session, she didnt feel the need to cry. I dont know what it is, Im just so sad inside, she said about why she regularly cried.

In her last podcast episode, which was uploaded two days before her death, Ryan was severely grieving the death of her beloved grandfather. The episode was recorded just a few hours after her grandfather died. Ive just kind of watched him wither away in the past two weeks and its really, really sad to watch someone who youve grown up your entire life and who you see as the manliest man ever just slowly deteriorate. And, its actually the hardest thing that Ive ever dealt with in my entire life, Ryan said through tears. It just sucks and I will miss him forever. This is just a part of life, but I am just worried that this is gonna send me into a deeper depression. Or maybe it will take me out of my depression a little bit to see that life is short and that we just dont have as much time as we think we do with people that we love or care about.

Co-host Kristen Carney said that they had just recorded a very candid episode about suicide, which they couldnt put out because of audio quality issues. She expressed an interest in rerecording the episode, but wondered if the death of Ryans grandfather had changed her views about suicide.

Ryan expressed confusion over how well her mother was handling the death of the grandfather compared to her. Carney recommended that she ask her doctors at her next TMS treatment to possibly get her on some sort of depression medication to stave off a further spiral. Stevie expressed concern about asking for medication because she says on the last visit they wanted to prescribe her Lithium, which she wanted to stay away from because of the side effects like hair loss and weight gain. Ryan had previously been on Prozac.

Carney also suggested that since Ryan was going through the grieving process, she should avoid isolating herself. Ryan replied that for the first time in a while, she did not feel like isolating herself.

Stevies story is a heartbreaking example of some of the painful realities of dealing with mental health disorders like severe depression, especially during very fragile times in our lives. People are not usually open to talking about their feelings or talking openly like like this, Ryan said in the podcasts first episode. The honesty and gallows humor in the podcast is much like comedian Paul Gilmartins Mental Illness Happy Hour, which has been running since 2011.

Another common theme in these two podcasts is the wisdom that professional success and fame is not the answer to happiness or depression relief. Gilmartin earned a good living on the TBS show Dinner and Movie, while Ryan found a lot of success with YouTube which led to her own VH1 sketch comedy show. When I was doing well in life, I was so lonely and depressed, she said of her time on television.

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Stevie Ryan chronicled her extensive depression treatments, including TMS, on her mental health podcast - Starcasm.net

By: Raul J. Rodriguez MD, DABPN, DABAM, MRO Special to the Boca and Delray newspapers

Treatment resistant depression is one of the most crippling and emotionally devastating conditions known to man. The loss of hope in ever recovering from a disease that does not respond to conventional treatment and has hopelessness as one of its symptoms can lead to a deadly downward spiral. Many good medications have been developed to treat Major Depression over the years, but sometimes the disease can be too severe and the medicine does not work. Some intensive treatments, such as ECT, are very effective but have severe side effects. This leaves many patients seeking a better solution. This dire need for a better solution led to the development of TMS.

So what exactly is TMS? TMS is the acronym for Transcranial Magnetic Stimulation, which is a cutting edge treatment for depression that involves stimulation of brain tissue using electromagnetic pulses. This noninvasive procedure improves symptoms of depression by activated the parts of the brain associated with mood control and depression. TMS has grown in popularity due to the high degree of effectiveness while having very few side effects and absolutely no circulation of medication in the bloodstream. The process starts with the placement of an electromagnetic coil over the scalp near the forehead. The motor strip, the area of the brain responsible for movement of limbs and muscles, is then mapped out. This is necessary in order to subsequently determine the location of the lateral pre-frontal cortex. The actual procedure involves a delivering a sequence of magnetic pulses to the left lateral pre-frontal cortex to induce stimulation. The magnetic pulses pass through the scalp and the skull to reach the target brain tissue. TMS activates the actual neurons by inducing an electrical current in the part of the brain cell called the axon. This current travels to the nerve cell body and then affects other connecting brain cells. This stimulation ultimately creates the powerful antidepressant effect. TMS is indicated when conventional treatments for Major Depression have not worked. TMS is also an option for individuals who suffer from Major Depression and do not wish to take medications. TMS was approved by the FDA for the indication of treatment resistant depression in 2008. Deep TMS, possible with the newer generation of TMS technology, was approved by the FDA for the indication of treatment resistant depression in 2013.

Deep TMS, also known as dTMS, refers to a more deeply penetrating form of TMS now possible using the newer generation of TMS technology produced by the Brainsway Corporation. Brainsway has engineered the H1 dTMS coil that was approved by the FDA for the indication of Treatment Resistant Depression. The H1 coil produces a magnetic pulse that stimulates a larger area than a traditional figure 8 coil. The stimulation also penetrates deeper, reaching 1.7 cm into the cortex. The benefits of this have to do with both a more complete stimulation of the target area as well as some stimulation of the neighboring areas of the brain that interconnect with the target area. The risk of dramatically losing efficacy from deviating even just 1mm from the target area is greatly diminished using a Brainsway device, as compared to a traditional figure 8 coil, due to the larger and deeper area of stimulation. The treatment session consists of 2,500 pulses delivered over a time span of approximately 20 minutes. This all helps yield higher rates of both response and remission of Treatment Resistant Depression.

Part 2 coming in August!

Dr. Rodriguez is the founder, CEO and Medical Director of the Delray Center For Brain Science, a true Brain Center which specializes in Treatment Resistant Depression, ADHD, OCD, Memory Disorders, and optimizing brain performance.

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A New Hope For Depression: Part 1 - Boca Newspaper (press release) (blog)

Shares of AeroVironment Inc. (AVAV - Free Report) have been gaining momentum over the last 12 months and have returned 30.5% compared with the Zacks categorized Aerospace- Defense Equipment Industry gain of 20.2%. Long-term earnings growth of the company is currently pegged at 15.0%.

AeroVironment reported a positive earnings surprise of 31.31% in fourth-quarter fiscal 2017. The company exited fiscal 2017 with a funded backlog of $78 million, which was up 18.4% year over year. This indicates growing demand for its products.

Proper execution of its strategic plans, domestic demand for its family of Tactical Missile Systems (TMS) and international demand for its family of small unmanned aircraft systems drove the top line in fiscal 2017 and is expected to drive its performance going forward.

The strategic investment made by the company has started to yield results. The investments made to build its TMS business continue to benefit the company. In fiscal 2011, TMS revenues were about $6 million. It has touched $75 million in fiscal 2017. TMS revenues currently account for 29% of total revenue and expect to contribute even more in 2018.

The company, with its advanced product portfolio, is poised well to gain from the federal government fiscal 2018 budget request, which includes procurement of line items associated with AeroVironment solutions.

In addition, expanding international customer base and increasing demand for its Unmanned Aircraft Systems are going to drive the performance of the company.

The Zacks Consensus Estimate for the company has moved up 4.2% to 50 cents for fiscal 2018 in the last 30 days.

Zacks Rank & Other Stocks to Consider

AeroVironment currently sports a Zacks Rank #1 (Strong Buy). Other top-ranked stocks in the same space worth considering are Curtiss-Wright Corporation (CW - Free Report) , Heico Corporation (HEI - Free Report) and Raytheon Company (RTN - Free Report) . All of them carry a Zacks Rank #2 (Buy). You can see the complete list of todays Zacks #1 Rank stocks here.

Curtiss-Wright Corporation reported an average positive earnings surprise of 5.11% in the last four quarters. Its 2017 Zacks Consensus Estimate has moved up 2.5% in last 90 days to $4.48 per share.

Heico Corporation reported an average positive earnings surprise of 5.76% in the last four quarters. Its 2017 Zacks Consensus Estimate has moved up 1.5% in last 90 days to $2.07 per share.

Raytheon Company reported an average positive earnings surprise of 5.16% in the last four quarters. Its 2017 Zacks Consensus Estimate has moved up 1.4% in last 90 days to $7.48 per share.

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Here's Why AeroVironment Should be Part of Your Portfolio - June ... - Zacks.com