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Category Archives: Tms

Slag Handling Service Market 2021: Comprehensive Research Including Top Companies like-TMS International, Phoenix Services, Harsco, Edw. C. Levy Co.,…

Posted: July 14, 2021 at 1:37 pm

Slag Handling Service Market 2021-2027 Financial Insights, Business Growth Strategies with Competitive Landscape

The Slag Handling Service Market Research study published byMarketInsightsReports, entitledGlobal Slag Handling Service Market Growth 2021-2027consists of the market share, size, segmentation,and current trends. The study also contains the numerical research of the global Slag Handling Service market on a global level and offers planning and designing statistics to boost business development. The report author has included key competitive landscape (upcoming identifiers) on past and future projections of Slag Handling Service market industrial growth in forecast time-period. It then sheds light on key development trends, regional application and type wise analysis in the Slag Handling Service market report.

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Top Companies in the Global Slag Handling Service Market are TMS International, Phoenix Services, Harsco, Edw. C. Levy Co., Stein Inc, Sidernet

Slag Handling Service Market Segmentation:

This report fragments the Global Slag Handling Service Market based on Types are-

Slag Removal Service

Reclamation of Metal

Based on Application, the Global Slag Handling Service Market are divided into-

Steel Slag Handling

Iron Slag Handling

Others

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Global Slag Handling Service Market: Regional Segment-

The Study Objectives Of the Slag Handling Service Market are:

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Some Major Points from Table of Contents:

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Slag Handling Service Market 2021: Comprehensive Research Including Top Companies like-TMS International, Phoenix Services, Harsco, Edw. C. Levy Co.,...

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Cybin Files its 13th Patent Application and Announces Digital Therapeutics Strategy – Business Wire

Posted: at 1:37 pm

TORONTO--(BUSINESS WIRE)--Cybin Inc. (NEO:CYBN) (OTCQB:CLXPF) (Cybin or the Company), a biotechnology company focused on progressing psychedelic therapeutics, today announced that it has filed its 13th new provisional patent application and has advanced the build-out of its digital therapeutics strategy.

The company is evolving its programs beyond the psychedelic molecule, into an eco-system that may potentially drive improved patient treatments through the advancement of its digital therapeutics development.

Led by Cybins innovation team, including its newly formed patient steering committee, Cybin has commenced the next phase of the companys digital therapeutics platform which will better enable the evaluation of patient outcomes through a highly secure, patient-centered data analytics platform for better pre- and post- psychedelic treatments.

The digital therapeutics platform, which is proprietary to Cybin and the subject of the companys 13th patent application, adds another dimension to the companys development programs. The aim of utilizing and leveraging cutting-edge technologies to support drug development candidates will be a top priority as both the industry and the company evolves.

Combined with the companys recently announced collaboration with Kernel (quantitative neuroimaging technology), Greenbrook TMS (operator of 129 outpatient mental health service centers in the United States), and the progression of other proprietary tools such as the EMBARK psychotherapy model, Cybin is building an advanced eco-system that can drive innovation from the psychedelic molecule, delivery of the molecule, quantitative testing of the molecule in patients to late-stage trials and one day potential patient treatments.

About Cybin

Cybin is a leading biotechnology company focused on progressing psychedelic therapeutics by utilizing proprietary drug discovery platforms, innovative drug delivery systems, novel formulation approaches and treatment regimens for psychiatric disorders.

Cautionary Notes and Forward-Looking Statements

Certain statements in this news release related to the Company are forward-looking statements and are prospective in nature. Forward-looking statements are not based on historical facts, but rather on current expectations and projections about future events and are therefore subject to risks and uncertainties which could cause actual results to differ materially from the future results expressed or implied by the forward-looking statements. These statements generally can be identified by the use of forward-looking words such as may, should, could, intend, estimate, plan, anticipate, expect, believe or continue, or the negative thereof or similar variations. Forward-looking statements in this news release include statements regarding enhanced liquidity, the value of additional capital markets exposure, access to institutional and retail investors, the Companys new strategic brand messaging campaign, and psychedelic drug development programs to potentially treat mental health disorders. There are numerous risks and uncertainties that could cause actual results and Cybins plans and objectives to differ materially from those expressed in the forward-looking information. Actual results and future events could differ materially from those anticipated in such information. These and all subsequent written and oral forward-looking information are based on estimates and opinions of management on the dates they are made and are expressly qualified in their entirety by this notice. Except as required by law, the Company does not intend to update these forward-looking statements.

Cybin makes no medical, treatment or health benefit claims about Cybins proposed products. The U.S. Food and Drug Administration, Health Canada or other similar regulatory authorities have not evaluated claims regarding psilocybin, psychedelic tryptamine, tryptamine derivatives or other psychedelic compounds or nutraceutical products. The efficacy of such products have not been confirmed by approved research. There is no assurance that the use of psilocybin, psychedelic tryptamine, tryptamine derivatives or other psychedelic compounds or nutraceuticals can diagnose, treat, cure or prevent any disease or condition. Vigorous scientific research and clinical trials are needed. Cybin has not conducted clinical trials for the use of its proposed products. Any references to quality, consistency, efficacy and safety of potential products do not imply that Cybin verified such in clinical trials or that Cybin will complete such trials. If Cybin cannot obtain the approvals or research necessary to commercialize its business, it may have a material adverse effect on Cybins performance and operations.

The NEO Exchange has neither approved nor disapproved the contents of this news release and is not responsible for the adequacy and accuracy of the contents herein.

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Cybin Files its 13th Patent Application and Announces Digital Therapeutics Strategy - Business Wire

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Greenbrook TMS (GBNH) Withdraws Proposed Share Offering – StreetInsider.com

Posted: June 28, 2021 at 10:01 pm

News and research before you hear about it on CNBC and others. Claim your 1-week free trial to StreetInsider Premium here.

Greenbrook TMS Inc. (NASDAQ: GBNH) today announced that it has elected to withdraw its previously announced public offering of common shares (the Offering). In light of market conditions existing at the time the Offering was commenced, and the subsequent completion of the Companys previously announced US$23.5 million private placement pursuant to Rule 506(c) under the U.S. Securities Act of 1933, the Company has determined to withdraw its short form base PREP prospectus in Canada and its registration statement on Form F-10 in the United States and, accordingly, will not be proceeding with the Offering.

This press release does not constitute an offer to sell or the solicitation of an offer to buy any securities in any jurisdiction in which such offer, solicitation or sale would be unlawful.

About Greenbrook TMS Inc.

Operating through 129 Company-operated treatment centers, Greenbrook is a leading provider of TMS therapy, an FDA-cleared, non-invasive therapy for the treatment of Major Depressive Disorder and other mental health disorders, in the United States. TMS therapy provides local electromagnetic stimulation to specific brain regions known to be directly associated with mood regulation. Greenbrook has provided more than 620,000 TMS treatments to over 17,000 patients struggling with depression.

Cautionary Note Regarding Forward-Looking Information

Certain information in this press release may constitute forward-looking information within the meaning of applicable securities laws in Canada and the United States, including the United States Private Securities Litigation Reform Act of 1995. In some cases, but not necessarily in all cases, forward-looking information can be identified by the use of forward-looking terminology such as plans, targets, expects or does not expect, is expected, an opportunity exists, is positioned, estimates, intends, assumes, anticipates or does not anticipate or believes, or variations of such words and phrases or state that certain actions, events or results may, could, would, might, will or will be taken, occur or be achieved. In addition, any statements that refer to expectations, projections or other characterizations of future events or circumstances contain forward-looking information. Statements containing forward-looking information are not historical facts but instead represent managements expectations, estimates and projections regarding future events.

Forward-looking information is necessarily based on a number of opinions, assumptions and estimates that, while considered reasonable by the Company as of the date of this press release, are subject to known and unknown risks, uncertainties, assumptions and other factors that may cause the actual results, level of activity, performance or achievements to be materially different from those expressed or implied by such forward-looking information, including but not limited to the factors described in greater detail in the Risk Factors section of the Companys current annual information form and in the Companys other materials filed with the Canadian securities regulatory authorities and the SEC from time to time, available at http://www.sedar.com and http://www.sec.gov, respectively. These factors are not intended to represent a complete list of the factors that could affect the Company; however, these factors should be considered carefully. There can be no assurance that such estimates and assumptions will prove to be correct. The forward-looking statements contained in this press release are made as of the date of this press release, and the Company expressly disclaims any obligation to update or alter statements containing any forward-looking information, or the factors or assumptions underlying them, whether as a result of new information, future events or otherwise, except as required by law.

View source version on businesswire.com: https://www.businesswire.com/news/home/20210625005484/en/

Glen Akselrod

Investor Relations

Greenbrook TMS Inc.

Email: investorrelations@greenbrooktms.com

Phone: 1-855-797-4867

Source: Greenbrook TMS Inc.

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Greenbrook TMS (GBNH) Withdraws Proposed Share Offering - StreetInsider.com

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Terminal Management System (TMS) Market Analytical Overview, Growth Factors, Demand and Trends Forecast to 2027 The Manomet Current – The Manomet…

Posted: at 10:01 pm

A recent market research report added to repository of Mart Research is an in-depth analysis of Global Terminal Management System(TMS) Market. On the basis of historic growth analysis and current scenario of Terminal Management System(TMS) market place, the report intends to offer actionable insights on global market growth projections. Authenticated data presented in report is based on findings of extensive primary and secondary research. Insights drawn from data serve as excellent tools that facilitate deeper understanding of multiple aspects of global Terminal Management System(TMS) market. This further helps user with their developmental strategy.

This report examines all the key factors influencing growth of global Terminal Management System(TMS) market, including demand-supply scenario, pricing structure, profit margins, production and value chain analysis. Regional assessment of global Terminal Management System(TMS) market unlocks a plethora of untapped opportunities in regional and domestic market places. Detailed company profiling enables users to evaluate company shares analysis, emerging product lines, scope of NPD in new markets, pricing strategies, innovation possibilities and much more.

Request a Sample Copy of this Report @ https://martresearch.com/contact/request-sample/3/8886

Segmented by CategoryHardware

Software

Services

Segmented by End User-SegmentOil & Gas

ChemicalsOthers

Segmented by CountryNorth AmericaUnited StatesCanadaMexicoEuropeGermanyFranceUKItalyRussiaSpainAsia PacificChinaJapanKoreaSoutheast AsiaIndiaAustralasiaCentral & South AmericaBrazilArgentinaColombiaMiddle East & AfricaIranIsraelTurkeySouth AfricaSaudi Arabia

Key manufacturers included in this surveyABB

Yokogawa Electric

Vopak

Triple Point Technology

Toptech Systems

Siemens

Schneider Electric

Rockwell Automation

Offspring International

Implico

Honeywell

General Atomics

Endress+Hauser

Emerson Electric

Agidens

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Table of Contents

1 Product Introduction and Overview2 Global Terminal Management System(TMS) Supply by Company3 Global and Regional Terminal Management System(TMS) Market Status by Category4 Global and Regional Terminal Management System(TMS) Market Status by End User/Segment5 Global Terminal Management System(TMS) Market Status by Region6 North America Terminal Management System(TMS) Market Status7 Europe Terminal Management System(TMS) Market Status8 Asia Pacific Terminal Management System(TMS) Market Status9 Central & South America Terminal Management System(TMS) Market Status10 Middle East & Africa Terminal Management System(TMS) Market Status11 Supply Chain and Manufacturing Cost Analysis12 Global Terminal Management System(TMS) Market Forecast by Category and by End User/Segment13 Global Terminal Management System(TMS) Market Forecast by Region/Country14 Key Participants Company Information15 Conclusion16 Methodology

Points Covered in the Report

The points that are discussed within the report are the major market players that are involved in the market such as market players, raw material suppliers, equipment suppliers, end users, traders, distributors and etc.

The complete profile of the companies is mentioned. And the capacity, production, price, revenue, cost, gross, gross margin, sales volume, sales revenue, consumption, growth rate, import, export, supply, future strategies, and the technological developments that they are making are also included within the report. This report analysed 12 years data history and forecast.

The growth factors of the market are discussed in detail wherein the different end users of the market are explained in detail.

Data and information by market player, by region, by type, by application and etc., and custom research can be added according to specific requirements.

The report contains the SWOT analysis of the market. Finally, the report contains the conclusion part where the opinions of the industrial experts are included.

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Terminal Management System (TMS) Market Analytical Overview, Growth Factors, Demand and Trends Forecast to 2027 The Manomet Current - The Manomet...

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Therapeutic Ultrasound Devices Market | Industry Insight 2021-2027 Covered players: , EDAP TMS, Dornier Medtech, InSightec, Siemens, and More The…

Posted: at 10:01 pm

The global Therapeutic Ultrasound Devices market is comprehensive and Insightful information in the report, taking into consideration various factors such as competition, regional growth, segmentation, and Therapeutic Ultrasound Devices Market size by value and volume. This is an excellent study specially designed to provide you with up-to-date information on important aspects of the Therapeutic Ultrasound Devices market. This report presents various market forecasts related to market size, production, revenue, consumption, CAGR, gross profit, price, and other key factors. Created using industry-leading primary and secondary research methods and tools.

The Major Players Covered in this Report:, EDAP TMS, Dornier Medtech, InSightec, Siemens, Philips Healthcare, SonaCare Medical, Wikkon, ,

In 2020, the global Therapeutic Ultrasound Devices market size was million US$ and it is expected to reach a million US$ by the end of 2027, with a CAGR between 2021 and 2027.

Get a Sample PDF Report:https://marketstrides.com/request-sample/therapeutic-ultrasound-devices-Market

Therapeutic Ultrasound Devices Market By Types

DesktopPortable

Therapeutic Ultrasound Devices Market By ApplicationsHospital TreatmentHome CareOther

Each part of the report contains important information about the global Therapeutic Ultrasound Devices market that can be used to drive strong growth in the coming years. A unique combination of primary and secondary research has enabled him to uncover hidden business opportunities in the global Therapeutic Ultrasound Devices market, gather meaningful insights from market participants, and obtain accurate market data. It covers a wide range of studies including production cost analysis, absolute dollar dividends, price analysis, business profiles, production and consumption analysis, and market dynamics.

Regional Analysis For Therapeutic Ultrasound Devices Market:

North America (United States, Canada, and Mexico)Europe (Germany, France, UK, Russia, and Italy)Asia-Pacific (China, Japan, Korea, India, and Southeast Asia)South America (Brazil, Argentina, Colombia, etc.)Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria, and South Africa)

In this study, the years considered to estimate the market size of the Therapeutic Ultrasound Devices are as follows:

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The study objectives of this report are:

For More Details On this Report:https://marketstrides.com/report/therapeutic-ultrasound-devices-Market

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Market Strides is a Global aggregator and publisher of Market intelligence research reports, equity reports, database directories, and economic reports. Our repository is diverse, spanning virtually every industrial sector and even more every category and sub-category within the industry. Our market research reports provide market sizing analysis, insights on promising industry segments, competition, future outlook, and growth drivers in the space. The company is engaged in data analytic and aids clients in due diligence, product expansion, plant setup, acquisition intelligence to all the other gamut of objectives through our research focus.

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Therapeutic Ultrasound Devices Market | Industry Insight 2021-2027 Covered players: , EDAP TMS, Dornier Medtech, InSightec, Siemens, and More The...

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Shockwave Therapy Device market 2021 Global analysis, opportunities and forecast to 2027 | By Top Leading Vendors like , Boston Scientific…

Posted: at 10:01 pm

The global Shockwave Therapy Device market is comprehensive and Insightful information in the report, taking into consideration various factors such as competition, regional growth, segmentation, and Shockwave Therapy Device Market size by value and volume. This is an excellent study specially designed to provide you with up-to-date information on important aspects of the Shockwave Therapy Device market. This report presents various market forecasts related to market size, production, revenue, consumption, CAGR, gross profit, price, and other key factors. Created using industry-leading primary and secondary research methods and tools.

The Major Players Covered in this Report:, Boston Scientific Corporation, Edaptms TMS, Lumenis Ltd., C.R. Bard Inc., Cook Group Inc., Dornier MedTech GmbH, Karl Storz, Olympus Corporation, Medtrue Enterprise Co. Ltd., Siemens AG, ,

In 2020, the global Shockwave Therapy Device market size was million US$ and it is expected to reach a million US$ by the end of 2027, with a CAGR between 2021 and 2027.

Get a Sample PDF Report:https://marketstrides.com/request-sample/shockwave-therapy-device-Market

Shockwave Therapy Device Market By Types

Mobile Shock Wave Therapy DevicesFixed Shock Wave Therapy Devices

Shockwave Therapy Device Market By ApplicationsHospitalsPhysiotherapy CentersClinicsRadiology LabsOthers

Each part of the report contains important information about the global Shockwave Therapy Device market that can be used to drive strong growth in the coming years. A unique combination of primary and secondary research has enabled him to uncover hidden business opportunities in the global Shockwave Therapy Device market, gather meaningful insights from market participants, and obtain accurate market data. It covers a wide range of studies including production cost analysis, absolute dollar dividends, price analysis, business profiles, production and consumption analysis, and market dynamics.

Regional Analysis For Shockwave Therapy Device Market:

North America (United States, Canada, and Mexico)Europe (Germany, France, UK, Russia, and Italy)Asia-Pacific (China, Japan, Korea, India, and Southeast Asia)South America (Brazil, Argentina, Colombia, etc.)Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria, and South Africa)

In this study, the years considered to estimate the market size of the Shockwave Therapy Device are as follows:

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The study objectives of this report are:

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Market Strides is a Global aggregator and publisher of Market intelligence research reports, equity reports, database directories, and economic reports. Our repository is diverse, spanning virtually every industrial sector and even more every category and sub-category within the industry. Our market research reports provide market sizing analysis, insights on promising industry segments, competition, future outlook, and growth drivers in the space. The company is engaged in data analytic and aids clients in due diligence, product expansion, plant setup, acquisition intelligence to all the other gamut of objectives through our research focus.

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Shockwave Therapy Device market 2021 Global analysis, opportunities and forecast to 2027 | By Top Leading Vendors like , Boston Scientific...

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Can Transcranial Magnetic Stimulation (TMS) Hurt You …

Posted: June 23, 2021 at 6:49 am

It has been almost a year since I decided to write up my story on how I came to be injured by transcranial magnetic stimulation (TMS). In all honesty, at that time I was convinced that my injury was some sort of mystery that I would never solve. I could have never known how much I would be able to learn on my own, just having the willingness to search for answers.

In the past year I have spoken to approximately a hundred people injured by TMS, countless doctors, and quite a few medical researchers and scientists. What I was able to learn and put together about the nature of TMS injury and the culture surrounding it yields an incredible insight into the treatment itself and into the nature of the medical model in its current form.

This article is devoted to the analysis of the harm currently being caused by TMS. It is not intended to provide a balanced view of the therapy or its practice.

First, I consider it important to identify the very clear set of symptoms that are emerging in the group of people harmed by TMS. After speaking with and reading the testimony of hundreds of people, the most common symptoms are:

Almost every person Ive spoken with experienced at least one of these, if not all of them.

Additional symptoms that are somewhat less common include:

Psychosis has also been observed in a few rare cases, but at least half of those specifically involve overuse of TMS (as described in this article).

It also became obvious to me that these symptoms manifest themselves in a very specific way. For instance, the worsening anxiety and/or depression is unrelenting and does not respond to treatment. As an example, before my TMS injury, when I was extremely anxious or depressed I would run longer and start eating really well, and this would always improve my symptoms to some degree. Typically, the harder I worked out, the better I felt, and the better I ate, the better I felt.

But after TMS, when I became depressed and anxious, exercise and eating did not help. I immediately began working out harder and harder and put myself on a stricter diet, which became stricter because I never got any relief from my symptoms. Every day I woke up feeling the same intense depths of despair, and I would become very anxious during the day. If I tried to meditate or run or use the CBT methods I had developed in the past, none of them made ANY difference at all. I found this to be remarkable and deeply disconcerting, which only compounded my situation.

Another characteristic of my TMS injury was that instead of improving in the months following TMS, I actually got worse. Immediately after TMS, I did not feel nearly as bad as I began to feel as time went on. Immediately after TMS, I still had my depression and anxiety, and I may have even felt slightly better due to the placebo effect and the hope that it was helping me.

However, about a month after TMS, I felt my symptoms were slowly intensifying until, about three months after TMS, they had become far more severe. The level of depression I felt was at least ten times what it was before. Also, instead of having anxiety occasionally bother me, I now had it all day, and panic attacks that I had only experienced once or twice in my whole life became a daily occurrence.

I concluded that this is what led to the subsequent increased, intense suicidal ideation that I experienced, which is what most others have mentioned to me when discussing their TMS injury as well. When you are extremely depressed and frequently panicking, suicidal ideation naturally follows; you come to believe you will never get any relief from the suffering and you begin to doubt if you can live with it.

To me, this is a normal human response to the trauma that TMS causes in the brain and on the nervous system. If we take a step back here and look at how these symptoms are manifesting, we can see this is delayed onset. New symptoms are continually manifesting after the initial injury has occurred.

This happens with most of the other symptoms as well. I developed constant muscle fasciculationsin my legs about three to six months after TMS. These were part of a larger muscularissue that began developing a few months after treatment: cramps, burning, numbness, and tingling in my legs, as well as sciatica. The symptoms slowly evolved over that period into what I am experiencing at present.

TMS appears to create a dysregulation of electrolytes in the body. I believe it to be sodium ion channelopathy acquired from the electrical injury. While this may be controversial, it is my suspicion that it is what is causing the muscle spasms along with the pain, numbness, weakness and tingling. While those symptoms are very common, we are seeing also some less common symptoms that appear to be a more severe form of this condition.

For instance, I am aware of people who have had episodes of syncope from hyponatremia after drinking too much water due to excess thirst or at the direction of their physicians because of muscle cramping. They have also experienced trouble breathing.

Before TMS, I would occasionally become dehydrated after paying too little attention to my water intake for a week or two. Now, if I drink less than 80 oz of water in a day, I will experience serious dehydration, intense muscle cramping, and increased cognitive impairment the following day.

Additionally, it appears that people are experiencing more instances of tinnitus when they had hearing protection properly in place for the duration of the TMS treatments than those that did not have hearing protection at the time of injury. This seems to suggest that the tinnitus is being caused by damage to the auditory cortex and not from external sounds. In fact, TMS treatment did not seem excessively loud to me or to others, although I do know that loud, repetitive noises can cause hearing loss. The auditory cortex of the brain is located close to the typical treatment site in TMS.

As I began to experience these symptoms and struggle to understand the reason, I began to think about similarities with each person I was speaking to. They all told me the details of their experience with TMS and, typically, any theories they had about medical injuryspecifically (and most often) psychiatric injury.

This led me to an interesting discovery. I began reading about the injuries that occurred with electroconvulsive therapy (ECT). My mind was almost instantly blown. I had been searching for a very long time to find some sort of cohesive explanation, a similarity to another type of injury or pattern that would give me some insight into what had happened to me. What I saw with ECT was that the types of injuries, the symptomology and the general fallout was very similaralmost exact.

Both injuries showed signs of traumatic/chronic brain injury, cognitive impairment, and neuromuscular and central nervous system (CNS) problems/agitation. I began searching the literature and found a community that was well-read in the evidence of the damage caused by ECT and the nature of diffuse electrical injury.

I realized it is important to understand not just the physiology of the damage caused by the injury, but also the kind of recovery people injured by TMS might expect.

The first important piece I read was an article by Jennifer Berg and Michael Morse. It is incredibly important because it describes both the diffuse electrical injury symptomatology and the difficultysome doctors have in addressing it because of the subjectivity of the symptoms. It describes thereasons for delayed onset of symptoms and damage, the psychological and physiological symptoms, and why the injury so rarely shows up on imaging and other diagnostics.

In summation, this article validates the theory of electrical injury and the difficulty doctors have verifying it. It is extremely important to point out that the problems with diagnosing and treating this injury are not the lack of evidence of injury but that doctors simply are not diligent enough in seeking the right conclusions to diagnose the injury.

The next important step is tying this electrical shock injury to TMS injury. You may think that since TMS does not use direct electrical current it is not shocking the brain or inducing electrical current into the brain, but that is not correct.

In fact, according to the manufacturers websites, you will typically find a statement that TMS is not the same as ECT. While this is true, it does not mean that TMS does not shock the brain and cause the same type of electrical trauma that ECT does. I think the fact that manufacturers overtly deny being an ECT treatment is very telling. TMS is obviously not ECT, just as it is obviously not an SSRI or talk therapy treatment. But unlike those, it does induce electricity into the brain.

I think the direct statement of difference is to try and diffuse an inherent connection people may make about having their brains shocked, the associated discomfort and obvious risks of such a treatment. TMS treatment is considered benign because it is less invasive (and less dramatic), but it is not.

Expert evidence presented in recent ECT litigation by Kenneth Castleman demonstrates that ECT causes damage by both heat and electroporation (that is, tearing holes in individual cell membranes so that they fail and cause cell death). Both heat and electroporation are generated by rapidly alternating electrical fields and are not exclusive to the physical manifestation of the electrical current itself. With TMS, electrical current is still being generated inside the skull by means of electromagnetic induction, as well.

Therefore, the same damage and impact on the brain is being exerted by the electromagnetic coil used in TMS. If you Google how TMS works, you will get the same answer: it works by generating rapidly alternating electrical fields, which we now know generate both heat and electroporation inside the human skull. In this way it is similar to ECT, simply without the direct electrical current applied to the temples. One could even say it is an evolution of ECT.

As if these similarities with ECT were not enough, we learn something else from the Castleman document: ECT practitioners go through a process of initially determining a patients seizure threshold. Clinicians have a testing session where they shock their patients with varying levels of electrical current to see what level of current is required to induce a seizure in the patient. After they have this data, they produce a seizure at a current somewhere between one and a half times to 12 times the seizure threshold.

In TMS, every patient is given an initial session where the clinician measures or maps the patients motor threshold. The patient is hooked up to the TMS machine and the clinician activates the machine and directs it at different parts of the brain to see if the patients hand twitches or not. To my knowledge, this is done so that the treatment will not induce a seizure.

However, the clinician has to specifically manipulate the machine to avoid inducing a seizure the way ECT does. This is further evidence that TMS is generating an electrical current inside the brain in a strikingly similar manner to ECT, and that it uses a similar methodology to measure its effects on a patient.

To understand the dangers of TMS, we need to understand the basics of the energy it uses. Electromagnetic waves such as the ones created by TMS are made up of two simultaneous types of energy: magnetic and electrichence the term electromagnetic wave or field.

TMS devices generate a minimum of a 1 to 1.5 tesla electromagnetic field. The electrical component of the field generated, based on this energy conversion table, is up to 797,700 to 1,196,550 milliamperes (mA) per square millimeter. In a study by Leo Alexander and Hans Lwenbach on specific damage done by ECT, they found that just 20 mA per square millimeter of brain tissue would causeirreversible damage to the tissue. TMS is far beyond the threshold established by the study.

The magnetic component of the field generates up to 10,000 to 15,000 gauss. The earth naturally generates a magnetic field of about .25 to .65 gauss, and the generally accepted safe occupational levels of gauss are generally set at 5 to 10 gauss. That means TMS could be generating anywhere from 1,000 to 1,500 times the amount of magnetic energy that is generally considered safe.

While electromagnetic fields do dissipate the further you are away from them, in TMS the coil is often held just millimeters away from the patients skull. This is causing damage to patients brains, and while the brain is a resilient organ, we cannot expect it to mitigate damage from that amount of force. The question is not why people are harmed by TMS but, rather, how is it that some are not harmed by TMS.

I have spoken to quite a few people who were not harmed, but claim they were helped by TMS therapy. One such person told me they felt better after TMS treatment and were not harmed in any way.

When I asked further questions about how long they felt good and if they still felt better today, they replied that the positive effect had lasted for a few months after theirlast treatment, but they slowly reverted back to theirprevious state. They also told me they were currently battling some significant depression and a bit of anxiety. That was very interesting but, sadly, not a surprise.

The surprise came next, when I asked if they had any suspicion of being harmed by TMS. They said they did not feel they had been harmed in any way. I then asked if they were sure and I listed all of the aforementioned symptoms associated with TMS and electrical injury. This is where things became very interesting: a few months after TMS, this person had a severe and long-lasting bout of sciaticawith no apparentphysiological cause. That is, this person had never had sciatica before and they found no explanation for the occurrence.

I asked some probing questions about how the sciatica could have come on and they simply had no explanation. This opened up a discussion about the sensations experienced during TMS, particularly the dip in which the patient becomes more depressed during TMS and then has to stick with treatment in order to come out of the dip. This person had experienced such a dip and had concerns about their health during treatment. They expressed a tremendous amount of concern and emotional discomfort in association with their treatment when speaking about it with me as well.

Coming away from this interview, both of us felt that maybe TMS was not as beneficial as they had originally thought. In fact, the conversation raised a few new concerns. This depressive dip that occurs during TMS could be a neurological response to acute brain trauma. Furthermore, ignoring that dip causes so much trauma within the brain that the patient begins to experience anosognosiabecoming unaware of their condition because they are in a kind of shock and no longer possess the faculties to properly understand their condition.

I experienced this same thing. I was having so much cognitive dysfunction I could no longer recognize the disoriented state TMS had induced in me. Additionally, I think the delayed onset of symptoms is due to a similar phenomenon. The nervous system is in a dysfunctional state for several months after the injury caused by TMS.

When it starts to recover, it now has injuries and impairments to its ability to function, and we see the long-term symptoms begin to emergesuch as the sciatica in this case. In other cases, such as mine, we see a more severe set of symptoms, such as cognitive impairment and neuromuscular issues. It is also possible that cognitive impairment accounts for some of the indifference to and lack of reporting of serious side effects. Physicians are often well aware of this possibility and choose to ignore it in many cases.

For those who follow TMS testimony closely, a typical objection to the existence of injuries is What about all the people it has helped? The truth of the matter is that we see the same thing with ECT. People claim real relief from the treatment, and it does have some amount of temporary efficacy.

This may occur because electricity always follows the path of least resistance. Everyones brain physiology and the variables involved in the treatment are different. Also, the brain is made up of at least seventy percent water, so the electrical current and fields generated inside the brain will follow a different path every time. This means that while one treatment could prove harmless, the next one could have devastating effects.

We see the same variability with lightning strikes. While one person can walk away perfectly fine, the next will be killed instantly or have severe neurological problems like we see in TMS or ECT. There is actually a very interesting article on its effects on a group of children that also corresponds to what we see in ECT and TMS.

Another trend I am now seeing is that, as with ECT, people who were at first successful with TMS are going back for subsequent treatments when the benefits wear off. They will have a relapse of symptoms and then become injured in subsequent treatments. I fear patients undergoing TMS will be pulled into the same debilitating loop as those given ECT.

The initial treatment may prove beneficial, but its efficacy will fade, as the therapeutic effect seems to be simply some kind of endocrine response to the trauma itself. Traumatic injury causes the body to release hormones that promote healing and reduce pain. But subsequent TMS treatments will lead to additional sensitization of the CNS to electrical injury, inevitably causing serious, life-altering harm to the patient.

As if all the aforementioned problems with TMS were not enough, I have seen another pattern emerge from the people I have spoken with. Many of the clinics administering TMS know very little about the treatment, the science of its effects, and even less about the brain, CNS, and human body. The staff is made up of trained technicians, not educated scientists.

The person who administered my treatments was newly trained and had no other medical training or knowledge. Their only knowledge of TMS was given to them by the manufacturers training personnelshortly before myvisit. I did not learn of this until well after my treatments had started.

Furthermore, during my treatments, the intensity of the machine was increased, creating a more intense feeling of drunkenness, lightheadedness, and impairment. When I describedthis to my technician and her manager, they both told me that they had to increase the intensity to reach the therapeutic effect. At this point, I was so desperate to make it work, I agreed. They did not know why, but they had been taught to do this.

Day after day, I made the same complaint, and they said it was normal. When I pressed them about it, they specifically told me that the manufacturer instructed them in training to turn up the intensity of the treatment regardless of patient complaints. The manufacturer told them to ignore patient complaints and turn up the intensity because there was no chance of harm during the process.

At this point, given all I have learned, experienced, and witnessed about TMS, I would disagree with that. It is bad enough that this happened to me, but worse knowing that those who came after me into that TMS clinic have experienced the same thing. I heard the same story from people injured by TMS all over the US, Canada, the UK, Australia, New Zealand, and Singaporevirtually all over the world.

Another disturbing pattern I identified was the use of TMS for off-label use. One gentleman I spoke with described severe anxiety, insomnia, and several other life altering problems after just one treatment. He could no longer work. He told me he was administered TMS for Irritable Bowel Syndrome (IBS).

I was in disbelief. I said,Do you have any history of mental health issues? He said, No, never. He had a very severe reaction to TMS; he could barely stand still and his voice was racing and disjointedobviously in rough condition. In his case the treatment was much worse that the disease.

This was not the only such story I heard. People have described TMS being used to treat their addiction problems, dementia, Alzheimers disease, pain, or to simply to improve brain function as well. The cases of Alzheimers and dementia are particularly troubling because these patients were already suffering from cognitive impairment. We risk making things much worse for patients who may not possess the awareness or ability to report further harms.

I have also heard from many people that they had relatively minor anxiety or depression and were asked by the office staff to exaggerate their responses to the PHQ-9 questionnaire so that TMS would be approved by insurance. People who go in for TMS are usually desperate for help and have been convinced that this is a no-risk miracle cure. This is a massive contributor to both these clinicsbank accounts and to inappropriate levels of risk and harm to their patients.

The Recovery

All of this has a huge impact on a persons physical and emotional health for many reasons. So, what happens when they go to a doctor for help with the harm done? Typically, and almost exclusively, the patient is invalidated, with doctors denying the possibility of any harm having been done to them from this treatment. This is simply because these experiences are not listed as a side effect in the common literature or on the manufacturerswebsite.

This is a fierce, fierce tragedy. Not only is someoneharmed seriously despite being told they wouldnt be, but now all the physicians they see deny theharm and sometimes even try to add an additional mental illness to theirdiagnosis simply because they were harmed by TMS.

It does not help that there is so little knowledge out there about electrical injuries. Once I learned that the injury is electrical in nature, I asked my doctors about it, but they had no insight nor any inclination to try to treat that type of injury, which is outside their specialty.

Interestingly enough, after I had queried all the usual medical resources, I called a largeand reputable electrical injury rehabilitation institute and described my injury to them without using the word TMS. Instead, I told them that I had my head next to a 1 to 1.5 tesla electromagnetic coil for 20 minutes a day for two monthsafter which they replied that they do commonly treat those types of injuries and they gave me the rundown on what they did and how much it would cost, which would not be covered by my insurance.

I found this to be very interesting. Once the buzzword TMS was removed from the situation, physicians told me several times, and in subsequent follow up emails, that this is indeed an injury they could attempt to rehabilitate me from.

As for the injury itself, the next problematic point is that it is very difficult to show brain injuries diagnostically. TMS is no different. Electroporation affects each cell individually as it expands and contracts the cell walls; therefore, each cell has its tipping point where it cannot recover its form and fails altogether, causing cell death. That, combined with the fact that the current and electromagnetic fields being generated fluctuate based on the conductivity of the matter they are interacting with, means there is no way to predict which cells will be affectedand which will not.

So, what we have is microscopic damage taking place throughout different, very small, particular areas of the brain which will not show on any kind of imaging test like anMRI, CT, or PET scan. I had several myself and have talked to countless others that have had the same, and so far we cannot see, nor have our technicians reports shown, any damage.

This makes it that much harder for doctors to believe their patientsalthough they do not have any reason to disbelieve them, either. It is very important to be aware that these scans also do not show damage caused by other meanseven those which are now well-establishedsuch as the brain damaging effects of psychiatric medications or chronic traumatic encephalopathy (brain damage caused by repetitive head injuries, typically in professional sports players).

These diagnostic techniques simply do not work as well in this area, even though there is very clearly significant damage to the brains function. In order for patients harmed by TMS to even begin to hope to recover, generally speaking, physicians need to start by acknowledging the injury. This is unlikely, however, due to the professional and financial pressure they are under to defend its highly profitable industry.

I do believe recovery is possible. Because of the way TMS injures the CNS, I believe that CNS sensitization is the primary issue to recover from. When our systems are overwhelmed enough or we come into contact with stimuli to which we are particularly sensitive, we experience panic attacks or sometimes other catastrophicsymptoms like tachycardia, syncope, or seizures. On top of this our general sensitivity to anxiety and depression seems to be heightened.

So far, the best approach I have found is to provide as much of a neutral environment for the CNS to recover as possible. This means, psychologically, as little stress and negativity as possible. This will give the CNS a safe space to repair itself and use whatever bandwidth it has freed up for that. I have also found diet to be essential: I really only eat organic food with no preservatives. Essentially, I eat like our ancestors do: primarily organic and free-range vegetables, fruit, fish, and poultry.

Healthy activity is incredibly important to keep our bodies functioning optimally. I shoot for at least 45 minutes of cardio per day. For some people, that is not realistic and they have to start smallthere is nothing wrong with that and it is actually the right move. Just keep active and engaged in your physical environment in ways that are not overly strenuous.

If we keep ourselves in a stimuli-neutral environment we can then introducethings that will help the brain recover cognitively as well. Playing games, listening to positive music, doing puzzles of all different kinds (like Legos, crosswords, etc.), and engaging in artwork to stimulate brain activity and create new neural networks that can build around our injuries and compensate for our losses.

It is key to focus on experiences you see as positive. Positive experiences are the building blocks of healthy brain activity and healing. This approach is the long-haul approach and with time, I think real recovery is possible and there is very little risk involved.

Recovering from injury caused by TMS demands respect and a healthy attitude toward healing just like all mental health challenges do. We cannot expect to solve these problems with more medications and therapies that have significant risks just so we can live the unhealthy lives that may be expected of us. It is time to focus on being human again, accepting and embracing the reality that comes with that, with all of our hearts and minds.

Lastly, I would like to express my sincere thanks to Sarah Price Hancock who has offered her indispensable brilliance in my endeavors to understand my injury and everything that comes with it.

***

Mad in America hosts blogs by a diverse group of writers. These posts are designed to serve as a public forum for a discussionbroadly speakingof psychiatry and its treatments. The opinions expressed are the writers own.

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TMS discusses thermal management in electric powertrains – Automotive Testing Technology International

Posted: at 6:49 am

Newly established tech company Thermal Management Solutions Group (TMS), which brings together different expertise to create one development powerhouse, says it is helping the industry to transition from the ICE to electrified powertrains with state-of-the-art fluid temperature control systems.TMS was officially formed in March 2021 from three automotive brands Dauphinoise Thomson, Magal and Wahler, and is said to be uniquely positioned with worldwide facilities and manufacturing capabilities. Paddy Lange, VP of global engineering and sales, discusses the demands and difficulties of engineering next-gen thermal management solutions.

What R&D projects is TMS currently working on?Many of theICEtemperature control systems applied in ICEs are also applicable in the hybrid market. What were working on here is increasing the value-added, so were working with customers to provide more of an integrated system to reduce the amount of vertical integration and provide something that we assemble and test to specification. This would mean that they dont need to buy different components, hoses and valves, etc or use as many suppliers. Some clients are also looking at adopting these subassemblies in their full EVs.

Were also working on electric valves for EV applications. These requirements are changing from what were used to with regard toICE. In full BEVs you have cooling requirements for several components such as the rotors, stators and power electronics. A lot of heat is generated, especially in the power electronics of higher-performance engines. Were working on being able to switch different circuits on and off, and the trend here is toward electric valves.

We are working on several electric vehicle projects, including, for example,an electric bus application.

For high-performance vehicles and trucks were still working onICEsolutions, and in the future theres a good chance these will go into battery applications for buses, too.

What are the thermal management considerations in an electrified engine?One of the biggest changes from an ICE to an electric powertrain is that many components have been eliminated. These engines do not have gearing. In BEVsyou dont have the high temperatures, but instead, you have low temperatures. In an electric powertrain, there are various different elements with different cooling requirements.

Cooling of the power electronics is a particular challenge as the method of cooling must be carefully chosen because having fluid and electronics close together is dangerous. This presents challenges with regard to leakage and sealing.

Although this all sounds quite straightforward, when it comes to reliability and ensuring that the vehicle can cope in different terrains, climates, and regions, the engineering detail thats required in this new phase is quite a lot, even with the most seemingly trivial challenges.

What has been the biggest challenge?Were using proven technology and innovating to alter it for battery-electric vehicle applications. A key element of this is getting up to speed with the different requirements and architectures. Companies are adopting different approaches, so establishing which customers we will be working with, and finding the right solutions for them, is a challenge.

One of the biggest difficulties has been acquiring knowledge, which relies on customers sharing their experiences. With the travel restrictions due to Covid, we havent been able to visit our customers.

As the industry is in this infancy stage, some players arent even sure what they need. Something that was touted a year ago, which we were certain would be the solution, is in some cases, a year later, perhaps not the latest thing that customers want or need. The advantage of being a medium-size company is that we have all development competencies in-house from conceptualization right through to production.

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API vs. RPA whats the difference? – FreightWaves

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By Omar Singh, president and founder, Surge Transportation

Do you remember studying something in school and asking yourself or your teacher, When am I ever going to use this? Well I asked that once of a professor when talking about a calculus class. He explained that we were not studying calculus because we were going to use it in whatever jobs we ended up having. We were studying it to learn how to solve complex, multistep problems: I know you are not going to use the quadratic equation in your job, but you are going to have to come up with solutions to complicated problems that involve many steps. I accepted that answer as it seemed to make sense, and honestly its been one of my favorite parts about building automation although only some of the problems are complicated and multistep; others are just routine, repetitive tasks.

Application programming interface vs. robotic process automation what is the difference? As I learn more about APIs and RPA, I think the main high-level difference is that one works inside your system as an integrated partner (API), while the other works outside your system as a guest user (RPA). They are both forms of automation that involve programming a logical series of decisions and then executing those decisions dozens or hundreds or thousands of times per day. I kind of work at the if/then level of decision making and then let the programmers write the code. If refrigerated, then bid; if hazmat, then apply accessorial; if past dates, then do not bid. If refrigerated hazmat with past dates, then which rule applies?

If you are using APIs, then you are integrated partners and working inside of a system in our supply chain world it is transportation management systems (TMSs) both shipper and service provider systems. Typically there is substantial financial investment developing the partnership and mapping the systems to communicate with one another. Rather than logging on each time, there is an authentication key that allows constant open access and exchange of information. Most of the information we exchange with shipper TMSs like BluJay, Blue Yonder, Mercury Gate and Oracle is load and rate information real-time rates. They provide the origin, destination, date and trailer type; we provide a rate. We repeat that exchange a lot. With our own brokerage TMS we have activated API capabilities and are automating go-live schedules for loads, target buy-rates and revenue codes. For example, if a quote ID is present, then, change the revenue code to real time; if no quote ID is present, then default the revenue code to primary award. The point here, though, is that we are integrated working inside of connected systems.

If you are using RPA, then you are not integrated and are working outside of the system as a guest logging on. The decisions can still be automated, tasks can still be automated, but the substantial financial investment is in programming the tasks from the outside rather than integrating a partnership from the inside. In the example of pricing, the bot is logging into a shipper TMS, either exporting or scraping load information, then leaving that system, likely logging on to a pricing engine to retrieve and apply logic to determine a rate, then perhaps logging into a broker TMS to record that rate, and going back to the shipper TMS to provide that rate. At the end of the day, its automation and applying a set of rules. The result is the same, its just from the outside.

Build vs. buy

In the past, I was a pure advocate of only buy. Let the tech companies do technology; let the supply chain companies build and move freight. I worked at large national supply chain firms with proprietary software that may have been cutting edge when they created it but could never really keep up year after year with periodic releases and updates the way technology companies can. Also, technology companies have the advantage of a large pool of different users who ask for modifications and enhancements that get pushed out to the community of other users. It is not just the ideas of a small team of developers that enhance the product, but the ideas of all of the users better results in the end.

However, in 2019 we started building as well and it has changed our whole business model it turned out to be good for us. We even bought an API module for our bought TMS, which allows us to build custom capabilities inside of the system and integrate automation with tools outside of the system. So for us its definitely both build and buy. We are a better company that can handle higher volumes with more accuracy while simultaneously reaching out to our carrier partners more quickly as a result of designing these multistep automatic or repetitive solutions. Im a big fan of doing whatever works for you yourself, your company, your family and recognize there is no one size fits all, but in the case of automation I think just find your way to get started and you should achieve some positive results. I havent met anybody who has said otherwise.

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API vs. RPA whats the difference? - FreightWaves

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AI and edge computing: the future of traffic management – Business Reporter

Posted: at 6:49 am

The benefits of traffic management systems in cities

A smart TMS is an artificial intelligence solution that is designed to analyse traffic and driver behaviours, which can then be used to detect unlawful actions on roads, such as running red lights, making illegal left turns, driving in the bus lane, speeding and so on. Its a little device with a camera that we attach to a traffic light or any pole on the street. Then, the infringements are noted and sent to the authorities, who can then choose to process them further as they see fit.

The benefits of using TMS are many. For one, it provides city planners with data on inhabitant behaviour. It can help them identify problem areas, which, as they have been identified, can then be solved. We installed a TMS system at an intersection that was notorious for the frequency of accidents that happened there, and we found that there was a high rate of red-light running. Now, the city can think about how to address this issue with its inhabitants.

From another angle, collected data on infringements can ease the process of issuing fines which in many cities is a manual process, and often undertaken with limited resources. As a result, this automated system can save municipalities resources and increase their income at the same time.

Sounds good, right? The problem is, until now, its been incredibly difficult, and the cost has been prohibitive for municipalities to implement such smart systems. Fortunately, with the development of 4G (and upcoming 5G) technologies, the costs are falling and installing smart traffic infrastructure is more than possible. The reason being that by connecting to the mobile network, you no longer have to obtain building permits to set up internet cables or wired sensor connections, which is time-consuming and expensive. All thats necessary is an electric connection and some kind of pole that it can be mounted to which is much easier to arrange.

Technology making smart TMS-es a reality

Implementing a TMS has never been more possible. The latest technologies make for the fastest and most economically efficient setup and maintenance, with the most diverse applications in terms of location and features. In fact, some are already up and running.

The mobile connection is the linchpin of the success of these systems. While current 4G networks have the capacity to handle a few prototypes, if you wanted to install these systems throughout the entire city at every intersection, youd need the heavy lifting that 5G offers. As mobile operators continue to roll out 5G throughout their cities, this is becoming more of a possibility.

Another piece of technology that makes these systems possible is edge computing. We use the 4G mobile network for connectivity, which gives us a lot of freedom and saves time to set up the solution. Edge computing solves the limited transmission volume challenge, making it possible to be free of cable connections. We can do all the AI video analysis right there in the device, and only use 4G to send analysed data. We save on building costs, server costs, network bandwidth and setup time.

A common concern we hear is that of privacy if there are cameras set up, then how is individual privacy upheld? These days, data privacy is an important issue and isnt to be taken lightly. The solution only identifies and saves traffic law offenders vehicle data when the specified driving behaviour has been identified such as running a red light. It will then save several photos and a short video in which both the car and traffic light are visible. This can then be used as proof by the police. The rest of the video stream is not saved, and even the police cant access it. Also, the saved events are stored only for the minimum period that is required by law. Were only interested in improving road safety, and we take privacy very seriously.

The time for smart cities is now

Were living at a time when what used to be considered the technologies of the future are now here and making them a reality is not only possible, but also cost-effective and convenient. At LMT, weve developed a ready-made system for municipalities, neighbourhoods or regions.

Find out more at https://trafficmonitoringtech.com/.

By Ingmrs Pis, VP and board member, LMT

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