Category Archives: Corona Virus

Zia Hellman, a teacher, helps her student, Averie Colvin, 5, at Walter P. Carter Elementary/Middle School in Baltimore.Credit...Rosem Morton for The New York Times

A Maryland legislative committee on Friday approved the State Board of Educations decision to allow all 24 local school districts to decide whether to require face coverings in schools.

The decision, effective immediately, ends an emergency order mandating the masking in schools that had been in effect since the beginning of the school year. Both Gov. Larry Hogan, a Republican, and the state superintendent of schools, Mohammed Choudhury, had lobbied for the decision, which came on the same day that the Centers for Disease Control and Prevention issued new masking guidance that allows many more areas of the country to ease pandemic restrictions.

Other states also announced the easing of some restrictions on Friday, including California, Colorado and Illinois.

The Maryland State Education Association, the union that represents 76,000 teachers and other support staff, had urged caution, asking for the mask mandate to remain in place longer.

The mandate was updated in December to allow local school systems the option to end the mask requirement if the spread of the coronavirus remains moderate or low for two weeks, or if the vaccination rate is higher than 80 percent in the school or community. A few school districts have passed the threshold, and one, Anne Arundel County, met the standards and decided to make masks optional. Face coverings will remain required on school buses.

Cheryl Bost, a fourth- and fifth-grade teacher who serves as the unions president, said in an interview that the system was working well and that school districts were reaching safe levels. She had urged waiting a week or two before removing the state mask mandate.

You must allow districts and families transitional time to make decisions, she said. There are students and educators currently able to take part in in-person instruction because of the mask mandate.

Ms. Bost, who is immunocompromised, said the union wants students and families with higher levels of vulnerability to have increased remote-schooling options. Educators with special medical needs should also have paid sick leave or alternate job placements, she said, and districts should continue to provide masks, testing and contact tracing to keep community transmission rates low.

Fewer than 10 states still require masks in K-12 schools, though federal guidance recommends that people in places with outbreaks, and all students, teachers and school staff members, wear masks regardless of their vaccination status. Connecticut, Delaware, Massachusetts, New Jersey and Oregon, among other states, have announced plans to lift statewide mask requirements in schools, citing the easing of the Omicron surge.

The Centers for Disease Control and Prevention will release new guidelines on Friday for determining when and where people should wear masks, practice social distancing and avoid crowded indoor spaces. According to two federal officials with knowledge of the plans, the guidelines will direct counties to consider three measures to assess risk of the virus: new Covid-related hospital admissions over the previous week, the percentage of hospital beds occupied by Covid patients and new coronavirus cases per 100,000 people over the previous week.

Using the new framework, Maryland is in a great place, Mr. Choudhury, the school superintendent, said Friday afternoon. We cant mask our kids forever. This is a good time to do it.

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Covid-19, Mask Guidance, and Testing News: Live Updates - The New York Times

Family members at a mass crematorium ground in East Delhi, India, in April 2021.Credit...Atul Loke for The New York Times

A new study estimates that at least 5.2 million children around the world lost a parent or other caregiver to Covid-19 in the first 19 months of the pandemic.

Children are suffering immensely now and need our help, said Susan Hillis, a senior researcher at the University of Oxford and a lead author of the study, which was published in the medical journal The Lancet on Thursday.

The study was based on data from 20 countries, including India, the United States and Peru, and was completed by an international research team that included experts from the Centers for Disease Control and Prevention, the World Health Organization and several colleges and universities.

It warns that a child who loses a parent or a caregiver could suffer negative effects including an increased risk of poverty, sexual abuse, mental health challenges and severe stress.

An earlier study, focused on the first 13 months of the pandemic, arrived at an estimate of 1.5 million affected children. The new figure is much higher not just because it adds data for six more months, researchers say, but also because the first estimate was a significant undercount. Using updated figures on Covid-related deaths, the researchers now calculate that at least 2.7 million children lost a parent or caregiver during the first 13 months.

The new study covers data through October 2021, and does not include the latest surge in cases from the Omicron variant, which have undoubtedly added to the toll.

It took 10 years for five million children to be orphaned by H.I.V./AIDS, whereas the same number of children have been orphaned by Covid-19 in just two years, Lorraine Sherr, a professor of psychology at University College London and an author of the study, said in a statement.

Davyon Johnson, 11, from Muskogee, Okla., is one of the millions of children to have lost a parent in his case, his father, Willie James Logan, who died two days after being hospitalized with Covid in August 2021.

Its been a rocky road, Ill say it like that, Davyons mother, LaToya Johnson, said in an interview.

Davyon has dealt with the grief as best as he can, she said. His grades are still strong. Hes still eager to see friends. Still, there are days when they are both exhausted.

Up and down up and down, Ms. Johnson said of their emotions. Its him wanting to call his daddy and not being able to.

Darcey Merritt, a professor of child welfare at New York University who was not involved in the study, said the deaths of parents and caregivers would have a long, far-reaching impact on children, especially those in lower-income households.

Children of color in the United States, she added, are particularly at risk of negative consequences.

A study in the journal Pediatrics last year found that in the United States, one in every 168 American Indian or Alaska Native children, one in every 310 Black children, one in every 412 Hispanic children, and one in every 612 Asian children had lost a caregiver, compared with one in 753 white children.

The study in The Lancet found that two out of three children orphaned are between 10 and 17, and a majority of the children who lost a parent lost their father.

Juliette Unwin, a lead author of the study from Imperial College London, said in a statement that as the researchers receive more data, they expected the figures to grow 10 times higher than what is currently being reported.

The pandemic is still raging worldwide, Dr. Unwin said, which means Covid-19-related orphanhood will also continue to surge.

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Covid News: Several Parts of U.S. Ease Mask Rules - The New York Times

Sir Patrick Vallance, the governments chief scientific adviser, and Sir Chris Whitty, Englands chief medical officer, became household names after they were propelled into the spotlight by the Covid pandemic. For the past two years, they have flanked Boris Johnson at Downing Street briefings armed with PowerPoint slides and exponential curves. But with the announcement this week of Englands plan for living with Covid the advisers are expected to take a step back. Here are some of their most memorable moments.

Early in the coronavirus pandemic, Sir Patrick Vallance suggested that building herd immunity in the UK through widespread transmission could be the UKs strategy for handling the pandemic.

On 13 March 2020, Sir Patrick Vallance, speaking to the BBCs Today show, said the key things the UK needed to do was to fight the pandemic was to build up some degree of herd immunity, saying that because the vast majority of people with coronavirus get a mild illness, herd immunity would mean that more people are immune to the virus and transmission would be reduced.

The concept of building herd immunity through exposure prompted backlash and was criticised by figures such as former health secretary Jeremy Hunt.

Speaking to the health select committee on the 17 March 2020, Sir Patrick Vallance stated that if the number of coronavirus deaths reached 20,000 or below, that would be a good outcome, although it would still be horrible and an enormous number of deaths.

Of course, the UKs total coronavirus death toll greatly surpassed this prediction. As of 25 February 2022, there were a total of 161,104 deaths recorded within 28 days of a positive test.

Amid the controversy over Dominic Cummingss journey to Durham during lockdown, Whitty and Vallance were asked whether they were entirely comfortable with the prime minister telling you you cant answer questions about Dominic Cummings.

In response, Chris Whitty said: I can assure you, the desire not to get pulled into politics is far stronger on the part of Sir Patrick [Vallance] and me than it is on the prime minister.

Vallance added: Im a civil servant, Im politically neutral and I dont want to get involved in politics at all.

On 10 June 2020, When looking at specific ways the UK could have improved their response to the coronavirus pandemic when it first emerged, Whitty said that if he had to choose one issue, it would be looking at how we could speed up testing early on in the epidemic.

There are many good reasons why it was tricky, but if I was to play things again, and this is largely based on what some other countries were able to do, in particular Germany, I think thats the one thing we would have put more emphasis on at an earlier stage.

In April 2020, the UKs daily coronavirus testing rate had only just passed 10,000.

In June 2021, a video was widely shared on social media of a man putting Whitty in a headlock when he declined to be in a photograph with him.

Whitty later said that he did not think anything of it and was surprised that the media picked up on it.

Im sure he will become a model citizen in due course, he added.

Both Lewis Hughes and Jonathan Chew, who were both involved in the incident and appeared in the video, were prosecuted.

Jonathan Chew was sentenced to eight weeks in prison in January after admitting harassment of Whitty on 29 June 2021.

Lewis Hughes, who was sacked from his job as an estate agent after the incident, received a suspended sentence last July for his involvement.

Asked about claims by the rapper Nicki Minaj that the coronavirus vaccine could make you impotent, Whitty said that people who know they are peddling untruths should be ashamed.

He said: There are a group of people who have strange beliefs, and thats fine but there are also people who go round trying to discourage other people from taking a vaccine which could be life saving.

And many of those people, I regret to say, know that they are peddling untruths, and still do it. And in my view, they should be ashamed.

In December last year, as the Omicron wave started taking off, Whitty said that people should prioritise what matters, and that by definition means de-prioritising other things.

I think I would recommend that, and most people would recommend that, and you dont need a medical degree to realise that is a sensible thing to do with an incredibly infectious virus.

At the time of Whittys comments, Independent Sage published a statement calling for an emergency circuit break lockdown given the rise of the Omicron variant, with numbers of infections doubling in England every two days.

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PowerPoint slides and exponential curves: Vallance and Whittys best bits - The Guardian

(THE CONVERSATION) Thankfully, most people who get COVID19 dont become seriously ill especially those who are vaccinated. But a small fraction do get hospitalized, and a smaller fraction do die. If you are vaccinated and catch the coronavirus, what are your chances of getting hospitalized or dying?

Asan epidemiologist, I have been asked to respond to this question in one form or another throughout the pandemic. This is a very reasonable question to ask, but a challenging one to answer.

To calculate the risk of hospitalization or death after getting infected with SARS-CoV-2 you need to know the total number of infections. The problem is that nobody knows exactly how many people have been infected by the coronavirus. So while it is very hard to estimate the true risk of dying if you are vaccinated and come down with COVID-19, there are some ways to better understand the risks.

Counting infections

The first thing to consider when thinking about risk is that the data has to be fresh. Each new variant has its own characteristics that change the risk it poses to those it infects. Omicron came on quickly and seems to be leaving quickly, so there has been little time for researchers or health officials to collect and publish data that can be used to estimate the risk of hospitalization or death.

If you have enough good data, it would be possible to calculate the risk of hospitalization or death. You would need to count the number of people who were hospitalized or died and divide that number by the total number of infections. Its also important to take into account time delays between infection, hospitalization and death. Doing this calculation would give you the true infection hospitalization or fatality rate. The trouble is health officialsdont know with certainty how many people have been infected.

The omicron variant is incredibly infectious, but therisk of it causing significant illness is much lowercompared to previous strains. Its great that omicron is less severe, but that may lead to fewer people seeking tests if they are infected.

Further complicating things is the widespread availability of at-home test kits. Recentdata from New York Citysuggests that 55% of the population had ordered these and that about a quarter of individuals who tested positive during the omicron surge used a home test. Many people who use home tests report their results,but many do not.

Finally, some people who do get symptoms simply may not get tested because they cant readily access testing resources, or they dont see a benefit in doing so.

When you combine all these factors, the result is that the official, reported count of coronavirus cases in the U.S. isfar lower than the actual number.

Estimating cases

Since the beginning of the pandemic, epidemiologists have been working on ways to estimate the true number of infections. There are a few ways to do this.

Researchers have previously usedantibody tests resultsfrom large populations to estimate the prevalence of the virus. This type of testing takes time to organize, and as of late February 2022, it doesnt appear that anyone has done this for omicron.

Another way to estimate cases is to rely onmathematical models. Researchers have used these models to make estimates oftotal case numbersand also forinfection fatality rates. But the models dont distinguish between estimated infections of vaccinated and unvaccinated individuals.

Research has shown time and again that vaccinationgreatly reduces ones risk of serious illness or death. This means that calculating the risk of death is only really useful if you can distinguish by vaccination status, and existing models dont enable this.

Whats known and what to do?

Without a good estimate of total cases by vaccination status, the best data available is known cases, hospitalizations and deaths. While this limited information doesnt allow researchers to calculate the absolute risk an individual faces, it is possible to compare the risk between vaccinated and unvaccinated people.

The mostrecent data from the Centers for Disease Control and Preventionshows that hospitalization rates are 16 times higher in unvaccinated adults compared to fully vaccinated ones, andrates of death are 14 times higher.

What is there to take away from all this? Most importantly,vaccination greatly reduces the riskof hospitalization and death by many times.

But perhaps a second lesson is that the risks of hospitalization or death are much more complicated to understand and study than you might have thought and the same goes for deciding how to react to those risks.

I look at the numbers and feel confident in the ability of my COVID-19 vaccination and booster to protect me from severe disease. I also choose to wear a high-quality mask when Im indoors with lots of people to lessen my own risk even further and to protect those who may be unable to get vaccinated.

There have been many lessons learned from this pandemic, and there are many things researchers and the public still need to do better. It turns out that studying and talking about risk is one of them.

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If I am vaccinated and get COVID-19, what are my chances of dying? The answer is surprisingly hard to find - KRQE News 13

Last June, as the Delta variant sat poised to take the globe by storm, Pfizers CEO, Albert Bourla, promised the world speed. Should an ultra-mutated version of SARS-CoV-2 sprout, he said, his company could have a variant-specific shot ready for rollout in about 100 daysa pledge he echoed in November when Omicron reared its head.

Now, with the 100-day finish line fast approaching and no clinical-trial data in sight, the company seems unlikely to meet its mark. (I asked Pfizer about this super-speedster timeline; when we have the data analyzed, we will share an update, the company responded.) Moderna, which started brewing up an Omicron vaccine around the same time, is eyeing late summer for its own debut.

Not that an Omicron vaccine would necessarily make a huge difference, even if Pfizer had made good. In many parts of the world, the variants record-breaking wave is receding. Having a bespoke vaccine in 100 days would have been an unprecedented accomplishment, but Omicron was simply too fast for a cooked-to-order shot to beat it, says Soumya Swaminathan, the chief scientist at the World Health Organization. This time, all things considered, we got lucky: Our original-recipe vaccines still work quite well against the variant, especially when theyre delivered as a trio of jabsenough that some researchers have wondered whether well ever need the elusive Omivax.

But Omicron wont be the last antibody-dodging variant that splinters off of the SARS-CoV-2 treewhich means the vaccines, too, will need to keep coming. Tough decisions are ahead about what triggers might prompt a whole new variant-specific vaccine campaign, and how well manage the shift in time. That said, we dont have to resign ourselves to a bleak future of infinite catch-up, with shots always lagging strains. Vaccine updates might not be that necessary that often, and when they are, we can poise ourselves to rapidly react. Rather than scrambling to sprint after SARS-CoV-2 every time it surprises us, we could watch the virus more closely, and use the intel we gather to act more deliberately.

To vaccinate properly against a variant, we must first detect it. That means keeping tabs on the coronavirus and rooting out the places where it likes to hide and transform.

Flu presents an excellent template for this sort of viral voyeurism. The viruses that cause that disease also shape-shift frequently enough to elude the immune systems grasp. For decades, scientists have been maintaining a massive, global surveillance network, now made of some 150 laboratories, that each year amasses millions of samples from sick people and susses out the genetic sequences of the viruses that linger within. That information then goes to the WHO, which convenes two meetings each yearone per hemisphereto decide which strains should be included in next winters vaccine.

A watchdog system for SARS-CoV-2 could piggyback off of flus. The symptoms of the two diseases overlap; hospitals are already collecting those samples, says Richard Webby, the director of the WHO Collaborating Center for Studies on the Ecology of Influenza in Animals and Birds. Youd just test them for two agents now. Scientists could scour coronavirus genomes for little red flagsbig-deal changes in the spike protein, say, that might befuddle antibodiesthen shuttle the most worrisome morphs to a high-security lab, where they could be pitted directly against immune molecules and cells. Based on flus model, ideal candidates for a vaccine revision might meet three criteria: Theyre riddled with unusual mutations; theyre recognized poorly by antibodies; and theyre spreading at least somewhat rapidly from one person to the next. A variant so heavily modified that it overcomes our immunity enough to make even healthy, vaccinated people quite sick would make the clearest-cut case for editing a shots recipe, Swaminathan told me.

Read: The coronavirus will surprise us again

In September, the WHO formed a new technical advisory group thats been tasked with recommending ingredient adjustments to COVID vaccines as needed; Swaminathan envisions the committee operating parallel to one that calls the shots for flu. But over time, the conditions that demand we take quick action for COVID vaccines might not arise all that often. At least some coronaviruses are thought to metamorphose more slowly and less dramatically than flu viruses, once they settle into a population, which could mean a less frantic variant pummel than what weve experienced so far. Some experts also hope that as the world continues to rack up infections and vaccinations, our immunity against this new coronavirus will hold better. Our defenses against flu have always been a bit brittlevaccine effectiveness for these shots doesnt start terribly high, then drops rather rapidly. If our shields against SARS-CoV-2 are more stalwart, and the virus genetically quiets, perhaps we will need to rejigger COVID vaccines less often than we do for flu.

Even against Omicron, the most heavily altered variant of concern identified to date, vaccine protection against severe disease seems extraordinarily sturdy. I dont think the entire population is going to need annual vaccines, Swaminathan told me. (The important exceptions, she noted, might be vulnerable populations, among them immunocompromised people and older individuals.) And when we do need vaccine revamps, the blistering speed at which mRNA shots can be switched up will be an advantage. Because most flu vaccines need about six months to slog through the production pipeline, vaccine strains are selected at the end of winter and injected into arms the next fall. That leaves a gap for the viruses to morph even more. mRNA shots like Pfizers and Modernas, meanwhile, couldOmicron saga notwithstandingzing from conception to distribution in about half the time, and eliminate a good chunk of the guesswork.

Some parts of this relatively rosy future may not come to passor at least, they could be a long way off. We just dont understand SARS-CoV-2 as well as we do flu viruses. In most of the world, flu viruses tend to wax in the winter, then wane in the warmer months, giving us a sense of the optimal time to roll out vaccines. And flu evolution occurs in a linear, ladderlike fashion; last years major strains tend to beget this years major strains. That makes it reasonably straightforward to predict the direction that flu viruses are going in and design our vaccines accordingly, says Emma Hodcroft, a molecular epidemiologist at the University of Bern.

The evolution of SARS-CoV-2, meanwhile, so far looks more radial, Webby told me, with new variants erupting out of old lineages rather than reliably riffing on dominant ones. Omicron, for instance, wasnt an offshoot of Delta. If we saw ladderlike evolution, we would know we need an Omicron vaccine now, Florian Krammer, a flu-virus expert at the Icahn School of Medicine at Mount Sinai, told me. Thats not what we have seen. The coronavirus has also so far been serving up new variants at an absolutely staggering clipfar faster than virologists expected it to at the pandemics startand scientists are unsure whether that churn will stop.

The coronavirus may eventually settle into more flu-like patternstrending its evolution to be more stepwise than starburst, or sticking to winter wavesas population immunity grows and it learns to better coexist with us. Host defenses, when theyre strong and abundant enough, have a way of constraining which paths a virus can take; perhaps they will slow the speed at which new variants arise and take over. The hope is that we head toward seasonality and stability, Helen Chu, a flu-vaccine researcher at the University of Washington, told me.

But theres no telling how long that transition will take, or how bumpy it will be, or if it will occur at all. Chu also worries that we dont yet have the proper infrastructure to pinpoint variants that gain steam in places where they can mutate unusually quickly: people with weakened immune systems, perhaps, or animals that can contract the pathogen and boomerang it back. (Similar events for flu, wherein other species pass a foreign version of the virus to us, can cause pandemics.) SARS-CoV-2 is unlikely to prefer exactly the same real estate that flu viruses do, and so our surveillance strategies will need to look different too. Even flu monitoring has notable holes: It still lags, for instance, in low-resourced parts of the globe. We need eyes and ears everywhere, Swaminathan told me.

For at least the short term, our COVID-vaccine-update process is likely to remain a bit plodding; variants will crop up, and our shots will pursue them. Even late-arriving shot rewrites arent necessarily useless, Hodcroft pointed out. Say our next variant is an Omicron descendant; dosing people up with Omivax could still prep the body for whats up ahead, even if the shot arrives too late to prevent past surges. That said, well also have to be careful about going all in on Omicron; several experts recently warned me that its probably premature to totally trash our original-recipe shots. If we went straight for an Omicron vaccine and stopped the others, that could potentially open up an immunity gap for the ancestral strains to mutate, and their descendants to roar back, says Cheryl Cohen, a member of the WHOs technical advisory group on COVID-19 vaccines and an epidemiologist at the National Institute for Communicable Diseases, in South Africa.

Read: Should we go all in on Omicron vaccines?

The pitfalls of pivoting from one spike version to the next are part of why this whack-a-mole approach of chasing single variants must end, says Raina MacIntyre, a member of the WHOs technical advisory group on COVID-19 vaccines and a biosecurity expert at the University of New South Wales, in Australia. Ideally, future vaccines should protect, with a single injection, against multiple variants at once. An easy first step would be to combine multiple spikes into one shotan Omicron-original combo, say, or an Omicron-Delta-original triple threat. Eventually, we might hit upon a universal formula that guards against all variants, including ones we dont know about yet, Hodcroft said. If the flus any indication, that could be an enormous challenge: Even after many years of study, weve struggled to find a catch-all shot for that disease. With SARS-CoV-2, we dont yet have a strong enough sense of all the evolutionary paths the virus could take; we may not be able to execute a wider-range shot until we understand our enemy better. Still, with so many efforts in the vaccine pipeline, Swaminathan is optimistic. I am fairly confident it is scientifically feasible, she said. It is no longer, Can we do it? It is, We can.

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How Often Will We Need to Update COVID Vaccines? - The Atlantic

SACRAMENTO, Calif. - Gov. Gavin Newsom has announced the state is rolling back executive orders put in place for the pandemic.

Newsom said he lifted all but 5% of COVID-19 related executive order provisions but the state will maintain provisions in key components of the states SMARTER Plan.

The state will also keep provisions for testing and vaccination programs. It will also keep provisions for hospitals and health facilities capacity.

As we move the states recovery forward, well continue to focus on scaling back provisions while maintaining essential testing, vaccination and health care system supports that ensure California has the needed tools and flexibility to strategically adapt our response for what lies ahead, Newsom said.

Before Friday, 15% of COVID executive actions remained in place.

Nineteen of the remaining provisions were terminated Friday, 18 will be terminated at the end of March. Newsom said another 15 will expire on June 30.

Seventeen executive actions remain in effect, which Newsom says will help with the states COVID-19 testing and vaccination programs. The executive actions highlighted are listed below:

The executive order can be found here.

Follow Action News Now on Facebook and Twitter for the latest news, weather and sports in Northern California.

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Gov. Newsom scales back COVID-19 executive actions, lifting all but 5% - Action News Now

Some research teams are focusing on the ACE2 receptor, a protein found on the surface of the cells of many species. The coronaviruss spiky protrusions allow it to bind to these receptors, like a key in a lock, and enter cells.

In 2020, a group of scientists compared the ACE2 receptors of hundreds of vertebrates, mostly mammals, with those of humans to determine which species the virus might infect. (The ACE2 receptors of birds, reptiles, fish and amphibians are not similar enough to ours to raise concern.)

The predictions have been very good so far, Harris A. Lewin, a biologist at the University of California, Davis, and an author of the study, said in an email. The scientists predicted, for instance, that white-tailed deer were at high risk for infection.

But some predictions proved entirely wrong: The paper identified farmed mink as a species of very low concern and then in April 2020 the virus raged through mink farms.

Indeed, ACE2 offers only a snapshot of susceptibility. Viral infection and immunity is much more complex than just a virus binding to a cell, Kaitlin Sawatzki, a virologist at Tufts University, said in an email.

And of the worlds nearly 6,000 mammalian species, scientists have sequenced the ACE2 receptors of just a few hundred of them, creating a biased data set. These sequenced species include model organisms used in experiments, species that carry other diseases, and charismatic zoo denizens, not necessarily the animals that people are most likely to encounter.

If a pandemic were to have arisen from a squirrel, we would be like, God, whats wrong with us? We didnt even measure the basic biology of a squirrel, Dr. Han said.

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If You Havent Thought About Coronavirus in Animals, You Should - The New York Times

LONDON The coronavirus forced Christopher Riley, a 53-year-old with blood cancer who lives in London, to strike a balance in the pursuit of normalcy. He would grab flowers from the buckets next to the entrance of a supermarket, but keep it quick. He went to Tate Modern, but on an early weekday morning. He would cook for friends, but only a small group who had all taken Covid tests.

Those accommodations allowed Mr. Riley to maintain something of a normal life as the virus roared through Britain, even though his condition meant that his immune system was compromised.

But now, after Prime Minister Boris Johnson announced on Monday that he was scrapping the coronavirus restrictions in England, Mr. Riley and other vulnerable people are afraid that even scaled-back activities will be too risky, leaving them further isolated even as the country opens up for most people.

Now I cant see how we can move forward into a sort of normality, he said, adding that the new approach will push him more into his house. There is nothing there to protect us.

A return to regular life was at the heart of Mr. Johnsons decision to roll back the remainder of Englands legally enforceable coronavirus restrictions, in what has been described as an effort to live with the virus. People who are infected will no longer have to isolate and most testing will no longer be free.

We must chart a course back towards normality as rapidly as possible, Mr. Johnson said during a news conference on Monday.

For Clare Dawson, that path had just been interrupted.

If there was someone walking around the streets whom you knew might kill you, would you go out? said Ms. Dawson, 41, who lives in London and has a chronic lung disease that puts her at greater risk of severe consequences from Covid-19.

Gemma Peters, the chief executive of Blood Cancer U.K., a charity that funds research into blood cancer, said that after the prime ministers announcement, its hotline was overwhelmed with calls from cancer patients asking what the new rules meant for them and whether it would be safe for them to go out.

We cant answer all the calls, Ms. Peters said. People use language like, Society doesnt care if I die, and I think that is the feeling that they are kind of collateral damage.

The British government said in a news conference that it would continue to protect the most vulnerable with targeted vaccinations and treatments, and that free tests would still be available for vulnerable people, but it acknowledged that lifting the remaining legal curbs would most likely cause a rise in cases.

Keeping free testing for the vulnerable? Thats too late, said Trishna Bharadia, 42, who has multiple sclerosis and has been largely isolating at home in Buckinghamshire, England, for the past two years. The aim should be to prevent the vulnerable from getting Covid in the first place.

Ms. Bharadia said she and her family watched Mr. Johnsons news conference on Monday in the living room from where they have watched virtual weddings, funerals, and birthday parties they havent been able to attend for the past two years.

We can only live with the virus if those protection measures continue, said Ms. Bharadia. Just because I have a health condition it doesnt mean that I matter less.

Still, the trend for fewer restrictions seems clear. On Tuesday, Scotland which is part of Britain but sets its own Covid policies also moved to roll back its legal coronavirus restrictions. Nicola Sturgeon, the first minister there, announced plans to lift mask mandates in March and said the countrys Covid certification scheme, which requires people to show proof of vaccination or a recent negative test in order to attend large events, would end this month.

And the British government has also withdrawn its guidance in England for staff and students at most schools and nurseries to test twice a week, even if they do not have symptoms. Infected children, just like the adults, will also no longer be legally required to self-isolate, but will be advised to do so.

Experts warned that this could lead children who have a weak immune system or live with vulnerable family members to be excluded from school.

Ceinwen Giles, 47, who developed an immune deficiency after her cancer treatment for non-Hodgkins lymphoma, said that her 12-year-old daughter would continue to go to school, but is anxious about the likelihood that she may be sitting next to children who might be infected.

This is how we have to live, said Ms. Giles, who is also joint chief executive of Shine Cancer Support, a charity for young adults with cancer. And no one seems to care.

In England and Wales, only 16.8 percent of people who died of Covid from October to December last year did not have a pre-existing health condition, according to the British government. For people who have a weaker immune system because of a disease or a treatment, Covid-19 can be more deadly, and vaccines often offer less protection.

Whether or not their condition forced them to take health precautions even before the pandemic, in the last two years many clinically vulnerable people have been forced into nearly total isolation, and even more so as mandates and restrictions have dropped around them. In the United States, many immuncompromised and higher-risk people have also felt left behind by the flurry of lifted restrictions.

You feel different again, said Ms. Dawson, adding that the new approach from the government had made her feel more alone in the face of the virus and forced to adopt her own precautions, stripped of the equalizing effect of rules.

Ultimately, people with health conditions understand the desire for life to return to normal, and say they are not asking for draconian restrictions.

Instead, they say that modest restrictions like mask mandates in transportation and supermarkets, and isolation requirements for infected people would make a big difference for the more vulnerable without causing a major disruption to everyone else.

The mask is just such a small thing, said Mr. Riley, 53. I cant wrap my head around how its such an issue for people.

Megan Specia contributed reporting.

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For Some in U.K., End of Covid Restrictions Threatens More Isolation - The New York Times

Oregon health officials reported 1,160 new coronavirus cases Wednesday and 35 deaths connected to COVID-19, along with an 18-bed drop in hospitalizations.

The decline in the number of beds occupied by COVID-19 patients statewide continues the trend of hospitalizations falling faster than anticipated by forecasts the state relies on to set some of its COVID-19 policy.

The Oregon Health Authority, which sets and repeals masking rules, used an older forecast to set March 31 as the cut-off date for lifting the public indoor mask mandate, allowing for an earlier date if hospitalizations fall to pre-omicron levels earlier than anticipated.

The data indicate hospitalizations are on track to fall to the threshold set by the state, 400 occupied beds, far sooner than the end of next month.

Since the omicron peak Jan. 27, hospitalizations have fallen an average of about 20 beds per day. Oregon is now 179 patients away from the 400 threshold.

Where the new cases are by county: Baker (2), Benton (19), Clackamas (78), Clatsop (6), Columbia (23), Coos (17), Crook (13), Curry (24), Deschutes (69), Douglas (42), Gilliam (1), Harney (3), Hood River (5), Jackson (118), Jefferson (24), Josephine (13), Klamath (11), Lake (3), Lane (87), Lincoln (14), Linn (38), Malheur (17), Marion (107), Morrow (4), Multnomah (166), Polk (27), Tillamook (12), Umatilla (22), Union (19), Wallowa (2), Wasco (26), Washington (120) and Yamhill (28).

Who died: The state did not immediately release details about those who died.

Hospitalizations: 579 people with confirmed coronavirus infections are hospitalized, down 18 from Tuesday. That includes 110 people in intensive care, up one from Tuesday.

Since it began: Oregon has reported 690,481 confirmed or presumed infections and 6,519 deaths, among the lowest per capita numbers in the nation. To date, the state has reported 7,352,004 vaccine doses administered, fully vaccinating 2,859,242 people and partially vaccinating 295,130 people.

To see more data and trends, visit https://projects.oregonlive.com/coronavirus/

Fedor Zarkhin

503-294-7674; fzarkhin@oregonian.com

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Coronavirus in Oregon: 1,160 new cases and 35 deaths as hospitalizations keep falling - OregonLive

Researchers showed last year that the elite school inside of lymph nodes where the B cells train, called the germinal center, remains active for at least 15 weeks after the second dose of a Covid vaccine. In an updated study published in the journal Nature, the same team showed that six months after vaccination, memory B cells continue to mature, and the antibodies they produce keep gaining the ability to recognize new variants.

Those antibodies at six months are better binders and more potent neutralizers than the ones that are produced one month after immunization, said Ali Ellebedy, an immunologist at Washington University in St. Louis who led the study.

In the newest study, another team showed that a third shot creates an even richer pool of B cells than the second shot did, and the antibodies they produce recognize a broader range of variants. In laboratory experiments, these antibodies were able to fend off the Beta, Delta and Omicron variants. In fact, more than half of the antibodies seen one month after a third dose were able to neutralize Omicron, even though the vaccine was not designed for that variant, the study found.

If youve had a third dose, youre going to have a rapid response thats going to have quite a bit of specificity for Omicron, which explains why people that have had a third dose do so much better, said Michel Nussenzweig, an immunologist at Rockefeller University who led the study.

Memory cells produced after infection with the coronavirus, rather than by the vaccines, seem less potent against the Omicron variant, according to a study published last month in Nature Medicine. Immunity generated by infection varies quite a lot, while the vaccine response is much more consistently good, said Marcus Buggert, an immunologist at the Karolinska Institute in Sweden who led the study.

Although most people, vaccinated or not, show only a small drop in their T cell response against Omicron, about one in five had significant reductions of their responses of about 60 percent, Dr. Buggert said. The differences are most likely because of their underlying genetic makeup, he said.

Still, the recent studies suggest that in most people, the immunity gained from infection or vaccination will hold up for a long while. Even if mutations in new variants change some of the viral regions that T cells recognize, there would still be enough others to maintain a reasonably strong immune response, experts said.

Excerpt from:

Got a Covid Booster? You Probably Wont Need Another for a Long Time - The New York Times