Category Archives: Cloning

Virology and veterinary bacteriology researchers at the Swiss University of Bern have succeeded in cloning the novel SARS CoV-2 coronavirus. The scientists were able to recreate the coronavirus from synthetic DNA (deoxyribonucleic acid) in the high-security laboratory of the Institute of Virology and Immunology (IVI) of the Federal Food Safety and Veterinary Office (FSVO) in Mittelhusern and at the Vetsuisse Faculty of the University of Bern. Corona samples can now be tested worldwide with these clones. This will also help discover drugs that will combat the viral disease and in the development of vaccines.

Viruses, like parasites, depend on a host cell in order to reproduce. The viruses invade the bodys cells and reprogram them so that they produce new viruses. These are then spread further, for instance through infection from droplets. The scientists in Bern have now reproduced segments of the coronavirus genome from synthetic DNA. These were then introduced into yeast cells. There they were reassembled by means of what is referred to as transformation-associated recombination (TAR) cloning.

This resulted in a yeast artificial chromosome (YAC) on which the genetic information of the virus was stored. In the next step, infectious RNA was reproduced in vitro without yeast cells. This was done with the help of T7 RNA polymerase. This RNA was introduced into animal cells, where new, synthetic coronaviruses were then replicated. As in clones. And all this was accomplished in record time. We replicated the virus within the space of a week,, notes Professor Volker Thiel from the Institute of Virology and Immunology (IVI).

The scientists report that the system of yeast cells was developed in Bern and has now proved its worth for the first time during an epidemic. We have optimized this system to allow us to clone coronaviruses and other viruses quickly, explains Prof. Jrg Jores from the Institute of Veterinary Bacteriology at the University of Bern. This method enables a rapid response to novel and fast-spreading viruses and their properties in real-time. In other words, during an outbreak.

The final results of the study were published in the academic journal Nature. This was after the provisional results had already been posted on a preprint server where it underwent scientific discussion is. The researchers state that the synthetic viruses cloned in Bern have enabled a major step forward in the diagnosis of patient samples and the development of new active substances. Viruses are especially difficult to clone because they are smaller than the smallest bacteria and extremely mutable. Our model system that uses yeast cells shows that it is ideally suited for reconstructing coronaviruses and other viruses, Volker Thiel adds.

This method developed by the Swiss researchers will also be suitable in the future for combating other extremely infectious viruses. Moreover, the scientists have already received numerous requests from companies and other researchers to test potential active substances against the SARS-CoV-2 coronavirus at the high-security laboratory.

Continued here:

Coronavirus clone from Switzerland goes 'viral' - Innovation Origins

CHINESE scientists have been accused of being real-life Dr Frankensteins who play God by cloning apes and editing the genes of babies.

Some of their work has been dubbed monstrous while other cutting edge research could lead to cures for Parkinson's and Alzheimer's.

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It's important to note that the US and the UK are not immune from conducting tests on animals and in fact carry out THOUSANDS of experiments on primates every year.

However, China has become the capital of research on apes and monkeys believing that our closest relatives hold the key to understanding brain disorders that destroy lives.

Incredibly, the Institute of Neuroscience (ION) in Shanghai, cloned five infant monkeys last year from an adult macaque who had been genetically-edited.

The result was baby primates intentionally born with a mutation that disrupts their wake-sleep cycle.

By giving the monkeys new drugs to treat their pre-existing brain disorders, the scientists hope to develop treatments for illnesses such as Alzheimer's disease.

It's no wonder the ION has been dubbed the "Cern of primate neurobiology".

The Institute successfully cloned two macaque monkeys in 2018 - a world first giving the experts confidence to push ahead with further experiments.

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Heaping praise on the research, the Chinese Academy of Sciences said: "The achievement heralds a new era in which China can produce batches of standardised monkey clones, which will serve as animal models in the research of the brain's cognitive functions, early diagnoses and interventions of diseases, as well as research and development of drugs.

While China allows genetic manipulation on animals it has banned the use of gene-editing on humans but that hasn't stopped some of its scientists "playing God" with unborn children.

Scientist He Jiankui, 35, rocked the scientific world when he revealed he had altered the embryos of twin girls in 2018.

In December last year, it was revealed that a third child born to a different mum had also been gene-edited.

The rogue expert said he used a tool called Crispr to disable a gene that allows the AIDS virus to enter cells in a bid to make the children immune from the disease.

But why have such experiments been dubbed monstrous by others within the scientific community?

Experts claim gene-editing in people could "divide humans into subspecies" and can cause mutations, genetic problems and even cancer.

Dr Kiran Musunuru, an expert in this area from the University of Pennsylvania, called the experiment unconscionable an experiment on human beings that is not morally or ethically defensible.

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Professor Julian Savulescu, of the University of Oxford, said: If true, this experiment is monstrous.

The embryos were healthy. No known diseases. Gene editing itself is experimental and is still associated with off-target mutations, capable of causing genetic problems early and later in life, including the development of cancer.

There are many effective ways to prevent HIV in healthy individuals: for example, protected sex.

Last December, Mr Jiankui was jailed for three years after news of the third child's birth was revealed.

He was convicted of practising medicine without a licence and fined 330,000 by a court in Shenzhen, the Xinhua news agency reported.

One of the most controversial experiments to date was the creation of embryos that were part human and part primate.

Last year, Spaniard Juan Carlos Izpisa Belmonte led a team of Chinese researchers with the end goal of creating monkeys which have entirely human organs such as kidneys or livers.

The organs will then be used for human transplants.

Based in China, the team made the chimeras a single organism with cells from more than one genotype - by injecting human stem cells into a fresh monkey embryo.

Biologist Belmonte previously tried adding human cells to embryos of pigs but the disturbing experiment was not successful.

However, because primates are genetically related to humans, the chances of the new research being successful is much greater.

The scientists also use gene-editing technology to disable certain cell formations in the animals to give the human cells a better chance of thriving.

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In the US and other western democracies, such research is banned however in China, experts are allowed to push the boundaries of scientific ethics.

Importantly, no Frankenstein monster has been born as a result of this research... not yet anyway.

Instead, the hybrid embryos are allowed to develop for around two weeks so their progress can be studied.

Mr Belmonte defended his work with the Chinese, saying: History shows us time and time again that, over time, our ethical and moral standards change and mutate, like our DNA, and what yesterday was ethically unacceptable, if this really represents an advance for the progress of humanity, today it is already an essential part of our lives."

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A similar experiment involved two piglets who were born with monkey cells in December at the State Key Laboratory of Stem Cell and Reproductive Biology in Beijing.

The so-called 'pig-monkey chimeras' died a week later.

Away from China, one of the most sinister experiments took place at the University of Munich where two monkeys were given transplanted pig hearts.

The poor creatures died after six months in a study which was deemed a success.

See the rest here:

Chinas scientists accused of playing God by creating monstrous cloned apes and primates with human organs - The Sun

Market Research Report on Hard Drive Cloning Software Market size | Industry Segment by Applications (Large Enterprises and SMEs), by Type (Cloud-based and Web-based), Regional Outlook, Market Demand, Latest Trends, Hard Drive Cloning Software Industry Growth & Revenue by Manufacturers, Company Profiles, Growth Forecasts 2025. Analyzes current market size and upcoming 5 years growth of this industry.

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Hard Drive Cloning Software Market Research Growth by Manufacturers, Regions, Type and Application, Forecast Analysis to 2025 - Express Journal

The report on the Disk Cloning Imaging Software market provides a birds eye view of the current proceeding within the Disk Cloning Imaging Software market. Further, the report also takes into account the impact of the novel COVID-19 pandemic on the Disk Cloning Imaging Software market and offers a clear assessment of the projected market fluctuations during the forecast period. The different factors that are likely to impact the overall dynamics of the Disk Cloning Imaging Software market over the forecast period (2019-2029) including the current trends, growth opportunities, restraining factors, and more are discussed in detail in the market study.

As per the presented market report, the global Disk Cloning Imaging Software market is projected to attain a CAGR growth of ~XX% during the assessment period and surpass a value of ~US$XX by the end of 20XX. Further, the report suggests that the growth of the Disk Cloning Imaging Software market hinges its hope on a range of factors including, emphasis on innovation by market players, surge in the investments pertaining to R&D activities, and favorable regulatory policies among others.

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The key players covered in this studyManageEngineSmartDeployCHENGDU Yiwo Tech DevelopmentSymantecParamount SoftwareNovosoftAOMEI TechnologySourceForgeSircksParagon Software GroupLSoft TechnologiesR-Tools TechnologyTom Ehlert SoftwarePrimeExpert SoftwareMiniToolDeepSpar Data Recovery

Market segment by Type, the product can be split intoCloud-BasedOn-PremiseMarket segment by Application, split intoEducationFinancial ServiceGlobal Service ProvidersIndustrial Control SystemHealth CareRetailGovernmentOther

Market segment by Regions/Countries, this report coversNorth AmericaEuropeChinaJapanSoutheast AsiaIndiaCentral & South America

The study objectives of this report are:To analyze global Disk Cloning Imaging Software status, future forecast, growth opportunity, key market and key players.To present the Disk Cloning Imaging Software development in North America, Europe, China, Japan, Southeast Asia, India and Central & South America.To strategically profile the key players and comprehensively analyze their development plan and strategies.To define, describe and forecast the market by type, market and key regions.

In this study, the years considered to estimate the market size of Disk Cloning Imaging Software are as follows:History Year: 2015-2019Base Year: 2019Estimated Year: 2020Forecast Year 2020 to 2026For the data information by region, company, type and application, 2019 is considered as the base year. Whenever data information was unavailable for the base year, the prior year has been considered.

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Measuring the Impact: Demand for Disk Cloning Imaging Software Product Augmented by Global Outbreak of COVID-330 - 3rd Watch News

It's not unusual to spot a trout species in a Calgary riverbut you might not expect to find a lobster-like crustacean.

In the last 10 to 20 years however, the marbled crayfish a crustacean not native to the Bow River has begun spreading to rivers and lakes throughout Alberta.

It's a problem that Nicole Kimmel, aquatic invasive species specialist for Alberta Environment and Parks, is trying to tackle.

Historically, the crustaceans are normally found in betweenWainwright andRyley in the Beaver River watershed south of Edmonton, Kimmel told The Calgary Eyeopener.

But now they've been showing up in water bodies anywhere from the Edmonton area, down to Calgary and Medicine Hat, as well as in the Milk River region.

It's not likely that the critters are crawling between rivers and lakes, though they can move on land for short periods, Kimmel said.

Instead, the provincesuspects the movements of the crayfish might be aided by humans either for bait use or they are potentially being brought back home and discarded in local waters.

"Once they're introduced to a breeding pair, they can breed pretty fast," Kimmel said the creatures can produce 200 to 400 eggs in a reproduction cycle.

Kimmel calls themarbled crayfisha kind of "freak accident" of two crayfish species that may have beenimported from Florida into Germany in the '90s and were able to mate. Through that mating, the crayfish kept an additional set of chromosomes that allowed them to reproduce asexually, meaningall the females could lay unfertilized eggs which develop into genetically identical offspring.

In essence, a self-cloning crayfish was born.

To attempt to control their spread, Alberta has banned the crayfish province-wide unless it'skept as a pet. Most pet stores have stopped carrying the specimens, but it's still possible to find them sold online by individuals.

Ducks have been munching on them, along withsome humans, but Kimmel says its important to make sure the ones used for consumption are coming from clean water sources.

Kimmel saysthe province has partnered with Mark Poesch, associate professor in Agricultural Life and Environmental Sciences at the University of Alberta, to understand what the effects are on the habitats the creatures are invading.

"We highly suspect that they're probably impacting food webs where they're being moved around," she said.

The marbled crayfish aren't the only species of their kind causing concerns there's an extensivelist of crayfish-type creatures being foundin Canadian waters,Kimmel explained.

For example, B.C. is worried about red swamp crayfish and in Manitoba there are concerns about crusty crayfish.

Meanwhile Saskatchewan, along with Alberta, has ramped up its legislation around marbled crayfish.

If you spot a crayfish, Kimmel says to report it to the provincealong with the location it was found.

"We're very much interested in knowing the location that you're finding them as well as if you can snap a picture of what they look like," Kimmel said.

"We don't want any of those other invasive ones that other jurisdictions are worried about."

The province isn't actively getting rid of the crayfish right nowuntil there's a better understanding of where the crayfishare located and what can be done for eradication.

See more here:

This self-cloning crayfish is scuttling into rivers and streams throughout Alberta - CBC.ca

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IBMGoogleLyrebirdNuance CommunicationsBaiduMicrosoftAWSAT&TNeoSpeechSmartbox Assistive TechnologyexCloneLumenVoxKata.AiAlt.AiCereProcAcapela GroupVocaliDVoiceryAristechCepstralIspeechVivoTextVoctro LabsrSpeakCandyVoice

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Market segment by Type, the product can be split into

CloudOn-premises

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Healthcare and life sciencesEducationMedia and entertainmentTelecomTravel and hospitalityBanking, Financial Services, and Insurance (BFSI)Others

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Global Voice Cloning Market Professional Survey 2020 by Manufacturers, Regions, Types and Applications, Forecast to 2024 - Latest Herald

on April 10, 2020 at 3:00 pm

The COVID-19 pandemic means a lot more video meetings than usual, often using Zoom. Bored with having to be on so many Zoom calls, creative technologist Matt Reed decided to build an AI-powered clone named Zoombot to handle the meetings for him

[M]y number of Zoom meetings have gone through the mesosphere and is currently on Mars, Reed wrote in a blog post about the project. Theres barely even time for bio-breaks, Reddit, or actually getting work done. Its as if Zoom has turned into the Oasis from Ready Player One where everyone spends every waking hour of their day inside.

To help take up the duty of sitting in on so many conference calls, Reed designed Zoombot to use speech recognition and text-to-speech to respond to his colleagues. The digital clone responds with, Im doing great thank you for asking, when asked, How are you? for instance, along with several other questions and statements. The video rotates through several images of Reed in front of his computer, making it seem like he has a bad connection. Reed didnt think it would fool anyone for long, but he didnt tell his coworkers about Zoombot ahead of time, and you can see their reactions in the video at the top.

To create the speech recognition and response system, Reed used Artyom.js, a library of tools for that purpose. Artyom can detect key terms and match them to responses in its program. Unlike a standard voice assistant, it doesnt require a wake word to activate, just the key phrases it will respond to. Reed is sharing Zoombot with the world for free on GitHub, so the next time you have a Zoom conference call, if someone seems more robotic than usual, it may be only their digital clone that theyve sent to the meeting in their place.

As it turns out, cloning oneself is actually much easier than Westworld would lead you to believe, Reed wrote. Now just crank up those speakers, fire up Zoombot, and freely go forth and enjoy all those other things youd rather be doing than sitting on video conferences all day. Just think, you could go play with the birds in your backyard, stare at your dog, make a fun smoothie, the possibilities are [in]finite.

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Otter Raises $10M to Bring AI Transcription Service to Japan

Eric Hal Schwartz is a Staff Writer and Podcast Producer for Voicebot.AI. Eric has been a professional writer and editor for more than a dozen years, specializing in the stories of how science and technology intersect with business and society. Eric is based in New York City.

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Bored of Zoom Meetings? Build a Digital Clone to Attend for You - Voicebot.ai

The lab which helped to clone Dolly the sheep are set to help in the fight against Covid-19 (Picture: PA)

The scientists responsible for cloning Dolly the sheep are reportedly in talks with the Government over a potential coronavirus treatment.

Researchers from TC Biopharm near Glasgow have used the new therapy which uses immunity-building cell transfusions to successfully treat cancer and plan to use immune cells from young and healthy volunteers to battle Covid-19.

The Daily Telegraph reported they are now hoping it will also work against the virus, and are in talks with the Government to trial the therapy for that purpose. It is hoped that the therapy will be available in NHS hospitals by July.

Dr Brian Kelly, senior strategic medical adviser to TC Biopharm, told the paper: One of the key challenges of fighting viral infection is to develop something that is going to attack the infected cells and not the normal cells.

So the solution that we came up with was to look at the bodys natural defences to viral infection.

Dr Kelly continued: In patients who have successfully fought a viral infection, they have expanded their own immune system and that persists after that to stop them becoming infected again.

For our Coronaviruslive blogclick here.

For all the latest news and updates on Coronavirus,click here.

The donor T-cells differ from normal immune cells. That is because they do not identify invaders in the body based on alien protrusions on the surface of cells, but by detecting the unusual metabolism of viruses.

When the donor cells detect a virus, they begin to destroy while also signalling it to the rest of the immune system as an alien intrusion requiring eradication.

Dr Kelly said that with this approach even if the virus mutated and returned to a body the infusion exercise could be repeated and would still work.

TC Biopharm was founded by Angela Scott, who was part of the team who cloned Dolly the Sheep in Edinburgh in 1996 in an iconic scientific moment.

There is currently no cure for Covid-19 though various vaccines are at different stages in their development across the world.

Today the UK recorded another surge in deaths linked to people hospitalised with Covid-19, as a toll of 708 brought the official total to more than 4,000.

Get in touch with our news team by emailing us atwebnews@metro.co.uk.

For more stories like this,check our news page.

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Scientists who cloned Dolly the sheep 'in talks over coronavirus treatment' - Metro.co.uk

Isabelle wouldn'tapprove.

Unscrupulous (or go-gettingly enterprising, depending on your perspective) Animal Crossing: New Horizons players have a crafty new tool at their disposal in their quest for financial superiority, arriving in the form of a freshly discovered item duplication exploit, enabling them to rack up hundreds of thousands of Bells with minimal effort if they so choose.

While some new island dwellers have been content to earn a crust the good old-fashioned way since New Horizons launched on Friday - through hard toil and, you know, selling a bunch of bees - others, using a method outlined by GameXplain, are riding roughshod over the laws of physics to conjure duplicate items out of thin air and flog them for potentially limitless funds.

All that's required in-game is a second player, the item you want to duplicate, and some sort of box or stand to put it on. First, the object in question must be placed on the box, which one player should then start rotating. The other player, meanwhile, should grab the object with Y, causing a copy to be added to their inventory while the original items stays where it is.

The process can then be repeated for further duplicates of that item, or to hoard boundless copies of any other item that a player has already acquired.

What you do with those duplicates is, of course, up to you; perhaps you'll spend your days rolling seductively around your living room abound in soft fruit, or perhaps, more practically, you'll make your rapid fortune by participating in some sort of illicit tarantula trade.

Becoming a Bellionaire in record time does seem to run counter to Animal Crossing's whole slow-and-steady ethos (this is, after all, a game that makes you toil for a damn item wheel), but can we really begrudge players grasping for a bit of financial stability in this darkest of timelines? We'll know how Nintendo feels about the whole thing based on how swiftly it decides to patch the sneaky glitch out of the game.

More here:

Animal Crossing: New Horizons item cloning exploit lets devious players rake in the Bells - Eurogamer.net

The recent study on Hard Drive Cloning Software Market Share | Industry Segment by Applications (Large Enterprises and SMEs), by Type (Cloud-based and Web-based), Regional Outlook, Market Demand, Latest Trends, Hard Drive Cloning Software Industry Growth & Revenue by Manufacturers, Company Profiles, Growth Forecasts 2026. Analyzes current market size and upcoming 5 years growth of this industry.

The Global Hard Drive Cloning Software Market gives us an in-depth overview of the research trends for the Financial Year 2020. This Report studies the Hard Drive Cloning Software industry on various parameters such as the raw materials, cost, and technology and consumer preference. It also provides with important Hard Drive Cloning Software market credentials such as the history, various expansions and trends, trade overview, regional markets, trade and also market competitors.

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The major market players operating in the industry are:

The study also illustrates the competitive landscape of foremost manufacturers in the industry with their diverse portfolio and geographical expansion activities. The Hard Drive Cloning Software market also includes participants financial overview which consists of an assessment of revenue outcomes, sales volume, gross margin, cash flow, capital investment, and growth rate which will allow clients to gain intact knowledge of participants financial strengths and position in the global Hard Drive Cloning Software industry.

By the product type, the market primarily split into:

By the product Applications, the market primarily split into:

Scope and Segmentation of The Report:

Our expert analyst has categorized the market into product type, application/end-user, and geography. All the segments are analyzed based on their market share, growth rate, and growth potential. The growth potential, market share, size, and prospects of each segment and sub-segment are portrayed in the report. This thorough evaluation of the segments would help the players to focus on revenue-generating areas of the global Hard Drive Cloning Software market.

Highpoints of Hard Drive Cloning Software Industry:

The study objectives are:

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Hard Drive Cloning Software Market Segmentation and Analysis by Recent Trends, Development and Growth by Regions to 2025 - Express Journal