Researchers have created the worlds largest ancient human gene bank by analysing the bones and teeth of almost 5,000 humans who lived across western Europe and Asia up to 34,000 years ago.
By sequencing ancient human DNA and comparing it to modern-day samples, the international team of experts mapped the historical spread of genes and diseases over time as populations migrated.
The astounding results have been revealed in four trailblazing papers published in the journal Nature and provide new biological understanding of debilitating disorders.
The study involved a large international team led byProfessor Eske Willerslevat the Universities of Cambridge and Copenhagen,Professor Thomas Wergeat the University of Copenhagen, andProfessor Rasmus Nielsenat University of California, Berkeley, with contributions from 175 researchers from around the globe. They found:
Future analysis is hoped to reveal more about the genetic markers of autism, ADHD, schizophrenia, bipolar disorder, and depression.
Northern Europe has the highest prevalence of multiple sclerosis in the world.
The new study foundthe genes that significantly increase a persons risk of developing multiple sclerosis (MS) were introduced into north-western Europe around 5,000 years ago by sheep and cattle herders migrating from the east.
By analysing the DNA of ancient human bones and teeth, found at documented locations across Eurasia, researchers traced the geographical spread of MS from its origins on the Pontic Steppe (a region spanning parts of what are now Ukraine, South-West Russia and the West Kazakhstan Region).
They found that the genetic variants associated with a risk of developing MS travelled with the Yamnaya people livestock herders who migrated over the Pontic Steppe into North-Western Europe.
These genetic variants provided a survival advantage to the Yamnaya people, most likely by protecting them from catching infections from their sheep and cattle. But they also increased the risk of developing MS.
It must have been a distinct advantage for the Yamnaya people to carry the MS risk genes, even after arriving in Europe, despite the fact that these genes undeniably increased their risk of developing MS. These results change our view of the causes of multiple sclerosis and have implications for the way it is treated.
Professor Eske Willerslev, jointly at the Universities of Cambridge and Copenhagen, Fellow of St Johns College, expert in analysis of ancient DNA and Director of the project.
The age of specimens ranges from the Mesolithic and Neolithic through the Bronze Age, Iron Age and Viking period into the Middle Ages. The oldest genome in the data set is from an individual who lived approximately 34,000years ago.
The findings provide an explanation for the North-South Gradient, in which there are around twice as many modern-day cases of MS in northern Europe than southern Europe, which has long been a mystery to researchers.
From a genetic perspective, the Yamnaya people are thought to be the ancestors of the present-day inhabitants of much of North-Western Europe. Their genetic influence on todays population of southern Europe is much weaker.
Previous studies have identified 233 genetic variants that increase the risk of developing MS. These variants, also affected by environmental and lifestyle factors, increase disease risk by around 30 percent. The new research found that this modern-day genetic risk profile for MS is also present in bones and teeth that are thousands of years old.
These results astounded us all. They provide a huge leap forward in our understanding of the evolution of MS and other autoimmune diseases. Showing how the lifestyles of our ancestors impacted modern disease risk just highlights how much we are the recipients of ancient immune systems in a modern world.
Dr William Barrie, postdoc in the University of Cambridges Department of Zoology and first author of the MS study.
Multiple sclerosis is a neurodegenerative disease in which the bodys immune system mistakenly attacks the insulation surrounding the nerve fibres of the brain and spinal cord. This causes symptom flares known as relapses as well as longer-term degeneration, known as progression.
The material in this press release comes from the originating research organization. Content may be edited for style and length. Want more? Sign up for our daily email.
Continue reading here:
Ancient DNA reveals reason for high MS and Alzheimer's rates in Europe - ScienceBlog.com
- DNA Tests and Stranded Bodies: Ukraine's Struggle to Name Its Dead - The New York Times - May 5th, 2024 [May 5th, 2024]
- Study highlights the role of dynamic DNA structures in memory consolidation - News-Medical.Net - May 5th, 2024 [May 5th, 2024]
- Two identical-looking athletes with same name get DNA test to see if they are long-lost siblings - UNILAD - May 5th, 2024 [May 5th, 2024]
- Patitz Awarded NSF Grant for Research on DNA-Based Nanostructure Research - University of Arkansas Newswire - May 5th, 2024 [May 5th, 2024]
- DNA on bandana leads to arrest of suspect in 2010 Indiana County robbery case - WTAE Pittsburgh - May 5th, 2024 [May 5th, 2024]
- DNA recovered from wine bottle leads to arrest of burglary suspect - WGN TV Chicago - May 5th, 2024 [May 5th, 2024]
- Junk DNA from Three Perspectives: Some Key Quotes - Discovery Institute - May 5th, 2024 [May 5th, 2024]
- Flipons: The discovery of Z-DNA and soft-wired genomes - Open Access Government - May 5th, 2024 [May 5th, 2024]
- New DNA evidence leads to arrest in 1984 cold case homicide of Everett woman - KING5.com - May 5th, 2024 [May 5th, 2024]
- Ancient DNA Reveals Kinship Structure of Eurasia's Avars - Archaeology Magazine - May 5th, 2024 [May 5th, 2024]
- Water bottle, DNA, fingerprints led to arrest of Chicago police officer Luis Huesca's accused killer, police say - CBS Chicago - May 5th, 2024 [May 5th, 2024]
- Jason Licht: Part of the DNA of this football team is trying to prove everybody wrong - NBC Sports - May 5th, 2024 [May 5th, 2024]
- New DNA evidence found in connection with 2014 Georgia murders of Shirley and Russell Dermond - GPB News - May 5th, 2024 [May 5th, 2024]
- Unraveling the roles of non-coding DNA explains childhood cancer's resistance to chemotherapy - Medical Xpress - May 5th, 2024 [May 5th, 2024]
- South Carolina's 'In Our DNA SC' aims for 100k participants in diverse health research - ABC NEWS 4 - May 5th, 2024 [May 5th, 2024]
- Joel Embiid finally discovers he has the DNA of a champion. Down 2-1, can he lead the Sixers past the Knicks? - The Philadelphia Inquirer - April 27th, 2024 [April 27th, 2024]
- Unraveling DNA's role in pop culturefrom superheroes to crime scenes - The Daily | Case Western Reserve University - April 27th, 2024 [April 27th, 2024]
- Elucidation of inhibitory effects of bioactive anthraquinones towards formation of DNA advanced glycation end products ... - ScienceDirect.com - April 27th, 2024 [April 27th, 2024]
- DNA Testing Proved My Innocence of My Son's Murder - Innocence Project - April 27th, 2024 [April 27th, 2024]
- Generative A.I. Arrives in the Gene Editing World of CRISPR - The New York Times - April 27th, 2024 [April 27th, 2024]
- Persistent TFIIH binding to non-excised DNA damage causes cell and developmental failure - Nature.com - April 27th, 2024 [April 27th, 2024]
- Enhanced CRISPR method enables stable insertion of large genes into the DNA of higher plants - Phys.org - April 27th, 2024 [April 27th, 2024]
- Scientists inspired the right guardrails for nuclear energy, the internet, and DNA research. Let them do the same for AI - Fortune - April 27th, 2024 [April 27th, 2024]
- Test your dog's DNA to learn about their heritage and health for only $120 - New York Post - April 27th, 2024 [April 27th, 2024]
- Earth Life Biodiversity: Vast DNA Tree Of life For Flowering Plants Revealed - Astrobiology - Astrobiology News - April 27th, 2024 [April 27th, 2024]
- Katie Holmes and Suri Cruise Share Some Very Stylish DNA - Vogue - April 27th, 2024 [April 27th, 2024]
- DNA evidence leads to arrest of 75-year-old Auburn man - Opelika Auburn News - April 27th, 2024 [April 27th, 2024]
- Putnam NY cold case: DNA test finds skeleton is not Robin Murphy's - The Journal News - April 27th, 2024 [April 27th, 2024]
- Ancient nomads you've probably never heard of disappeared from Europe 1,000 years ago. Now, DNA analysis ... - The Conversation - April 27th, 2024 [April 27th, 2024]
- Genetics Studies Have a Diversity Problem That Researchers Struggle To Fix - Kaiser Health News - April 27th, 2024 [April 27th, 2024]
- Keeping Telomeres in Their Places - The Scientist - April 27th, 2024 [April 27th, 2024]
- WWII veteran Ward Thomas identified through genealogy testing - 10TV - April 27th, 2024 [April 27th, 2024]
- Vast DNA tree of life for plants revealed by global science team using 1.8 billion letters of genetic code - Phys.org - April 27th, 2024 [April 27th, 2024]
- Here is a look at one of the labs that helped uncover new DNA evidence in Lake Oconee murder - WSB Atlanta - April 27th, 2024 [April 27th, 2024]
- This Guardians prospect has baseball in his DNA - 1330 WFIN - April 27th, 2024 [April 27th, 2024]
- DNA identifies last known remains of victims of notorious Green River Killer, cops say - Miami Herald - January 23rd, 2024 [January 23rd, 2024]
- UNE to study why rare lobsters have strange-colored shells - Spectrum News - January 23rd, 2024 [January 23rd, 2024]
- DNA evidence identifies last known victim of Green River Killer almost 40 years later - NBC Right Now - January 23rd, 2024 [January 23rd, 2024]
- New bill would give California parents more control over whether state can store their kid's DNA - CBS News - January 23rd, 2024 [January 23rd, 2024]
- Lucas County Sheriff's Office doing advanced testing on DNA found at site of 2011 Clarke and Straub murders - WTOL - January 23rd, 2024 [January 23rd, 2024]
- Last known remains connected to the Green River Killer identified through DNA | WTGS - Fox28 Savannah - January 23rd, 2024 [January 23rd, 2024]
- 5 Best Ancestry DNA Tests 2024 To Help You Learn More About Your Health - GLAMOUR UK - January 23rd, 2024 [January 23rd, 2024]
- 11 Investigates: Lucas County Sheriff's Office doing advanced testing on DNA found at site of 2011 Clarke and Straub murders - WTOL - January 23rd, 2024 [January 23rd, 2024]
- Researchers improve blood tests' ability to detect and monitor cancer - MIT News - January 23rd, 2024 [January 23rd, 2024]
- DNA test approved for Duxbury's Lindsay Clancy, who is accused of killing her 3 children - The Patriot Ledger - January 23rd, 2024 [January 23rd, 2024]
- 1,650th victim of 9/11 identified through advanced DNA testing - FOX 17 West Michigan News - January 23rd, 2024 [January 23rd, 2024]
- We Think Cavco Industries (NASDAQ:CVCO) Might Have The DNA Of A Multi-Bagger - Yahoo Finance - January 23rd, 2024 [January 23rd, 2024]
- DNA From the Ocean's 'Twilight Zone' Could Lead to New Lifesaving Drugs, Scientists Say - Smithsonian Magazine - January 23rd, 2024 [January 23rd, 2024]
- Last known remains connected to the Green River Killer identified through DNA - KOMO News - January 23rd, 2024 [January 23rd, 2024]
- 9/11 victim identified as John Ballantine Niven of Oyster Bay with help of DNA technology - WABC-TV - January 23rd, 2024 [January 23rd, 2024]
- Scott Peterson has every right to DNA test: Attorney from case - NewsNation Now - January 23rd, 2024 [January 23rd, 2024]
- DNA from stone age chewing gum sheds light on diet and disease in Scandinavia's ancient hunter-gatherers - The Conversation - January 23rd, 2024 [January 23rd, 2024]
- Barbara Lee responds to Nikki Haley: Racism is in the DNA of this country - The Hill - January 23rd, 2024 [January 23rd, 2024]
- DB Cooper 'will finally be identified' after 53 years due to huge DNA breakthrough - LADbible - January 23rd, 2024 [January 23rd, 2024]
- Dog Owners Who Abandon Poops To Be Found Using DNA Tests in Italy - Newsweek - January 23rd, 2024 [January 23rd, 2024]
- Scientists gather bobcat DNA from paw prints - KJZZ - January 16th, 2024 [January 16th, 2024]
- Discovering Fusions Requires More Than DNA Testing in GI Cancers - OncLive - January 16th, 2024 [January 16th, 2024]
- Largest-ever ocean DNA study uncovers mysteries of marine life - Earth.com - January 16th, 2024 [January 16th, 2024]
- 1st-ever ancient case of Turner syndrome, with just 1 X chromosome instead of 2, found in ancient DNA - Livescience.com - January 16th, 2024 [January 16th, 2024]
- Minnesota Mother Calls on NYS to Allow DNA Testing Finger Lakes Daily News - Finger Lakes Daily News - January 16th, 2024 [January 16th, 2024]
- DNA Didn't Match Marcellus Williams. Missouri May Fast-Track Execution Anyway. - The Intercept - January 16th, 2024 [January 16th, 2024]
- Ancient DNA From Eurasian Herders Sheds Light on the Origins of Multiple Sclerosis - Smithsonian Magazine - January 16th, 2024 [January 16th, 2024]
- DNA's hotel toh kuyabeh mirrors bird flight undulations in tulum - Designboom - January 16th, 2024 [January 16th, 2024]
- Research into ancient DNA sheds new light on cause of Multiple Sclerosis and other neurodegenerative diseases - University of Oxford - January 16th, 2024 [January 16th, 2024]
- Ancient DNA reveals reason for high MS and Alzheimer's rates in Europe - University of Cambridge news - January 16th, 2024 [January 16th, 2024]
- TIME-seq reduces time and cost of DNA methylation measurement for epigenetic clock construction - Nature.com - January 16th, 2024 [January 16th, 2024]
- Gilgo Serial Killer Suspect Rex Heuermann Tied to Slaying by DNA From Daughter's Can of Coffee: Prosecutors - The Messenger - January 16th, 2024 [January 16th, 2024]
- DNA evidence leads to arrest of Denton sexual assault suspect - The Cross Timbers Gazette - January 16th, 2024 [January 16th, 2024]
- Ancient DNA reveals reason for high multiple sclerosis and Alzheimer's rates in Europe - EurekAlert - January 16th, 2024 [January 16th, 2024]
- New technique identifies earliest cases of genetic disorders from ancient DNA - University of Oxford - January 16th, 2024 [January 16th, 2024]
- Ancient DNA could be hiding all kinds of health secrets - Deccan Herald - January 16th, 2024 [January 16th, 2024]
- Supreme Court seeks government's view on DNA profiling of unidentified bodies - IndiaTimes - January 16th, 2024 [January 16th, 2024]
- Prosecution Ordered to Release Portion of DNA Evidence to Kohberger's Defense Team - bigcountrynewsconnection.com - January 16th, 2024 [January 16th, 2024]
- Judge orders more DNA disclosure in University of Idaho murder case - KXLY Spokane - January 16th, 2024 [January 16th, 2024]
- Cas9-induced targeted integration of large DNA payloads in primary human T cells via homology-mediated end-joining ... - Nature.com - December 14th, 2023 [December 14th, 2023]
- The DNA glycosylase NEIL2 is protective during SARS-CoV-2 infection - Nature.com - December 14th, 2023 [December 14th, 2023]
- How an immune response is driven by one letter difference in DNA - Medical Xpress - December 14th, 2023 [December 14th, 2023]
- Tracy Morgan Discovered He Was Related to Nas After DNA Test - PEOPLE - December 14th, 2023 [December 14th, 2023]
- Scientists testify about DNA in third week of Aguirre trial - The Spokesman Review - December 14th, 2023 [December 14th, 2023]
- DNA metabarcoding focusing on the plankton community: an effective approach to reconstruct the paleo-environment ... - Nature.com - December 14th, 2023 [December 14th, 2023]