Genome scientist Evan Eichler and global health researcher Tulio de Oliveira have been named to 2022 TIME100. This is the magazines annual list of the hundred most influential people over the past year.
The full list and related tributes will appear on newsstands Friday, May 27, in the June 6/June 12 issue, and can now be viewed online at time.com/time 100. This is the nineteenth annual compilation of the list, which recognizes the impact of the worlds most influential people during the past year.
Eichler is a professor of genome sciences at the University of School of Medicine and a Howard Hughes Medical Institute Investigator. de Oliveira is an affiliate professor of global health, a joint UW medical school and UW School of Public Health department. His main faculty appointment is at the University of KwaZulu-Natal in South Africa. He is director of CERI (Centre for Epidemic Response & Innovation) and also founded KRISP, a state-of-the-art scientific facility in Africa created to support public health responses. KRISP is a partner in the global UWARN communicable disease outbreak monitoring network coordinated at the UW.
Evan Eichler, genome scientist noted for advancing comparative sequencing of human and primate genomes
Eichler, and the multi-university research group of Karen Miga, Adam Phillipy, and Michael Schatz, were honored together as a team in the Innovation category.They are credited with leading the recent effort to complete a gapless human reference genome.The achievement was published in Science April 1, along with a series of scientific papers analyzing different aspects of the finished genome.The work was the culmination of a large consortium, the Telomore-to-Telomere orT2T, which aimed to complete sequences of all 23 human chromosomes, end-to-end. Please see related news release.
A TIME tribute to the project team was written by Jennifer Doudna, a 2020 Nobel Laureate in Chemistry recognized for her work on CRISPR-Casp gene editing. She pointed out the significance of their recent achievement in advancing understanding of human evolution, common and rare diseases, and the structure and function of the human genome.
Eichlers lab and his graduate students, alongsidetheir work on the overall human genome completion project, contributed to advances in gene sequencing technology and analytics that allowed scientist to delve into difficult to decipher areas of the human genome. These regions were found to contain new information about what makes us distinctly human, in comparison to other primates. Their findings also provided insights into primate evolution. Other T2T studies in his lab are clarifying the structure and function of centromeres, which are critical for the accurate segregation of genetic material during cell division.
Among the many intriguing findings of the Eichler lab were certain human-only areas of repeated code. These human-specific areas of segmental duplication are reservoirs for new genes that drive the formation of more neurons and increase connectivity among synapses in the frontal cortex of the brain. This is the part of the brain where reasoning, logic and language functions take place.
Eichler was part of the original Human Genome Project back in 2001. He was fascinated by regions of the genome that were complex from the perspective that they were highly repetitive, but also encoded genes. Ever since the Human Genome Project was concluded, he had an intense desire to finish those parts of the genome that were felt to be inaccessible at that time. Now, he says, is not the end, as scientists have only finished a human genome. He looks forward to the completion of other human genomes to better showcase the diversity of humanity encoded in genome variation.
Global health emerging disease researcher Tulio de Oliveira
Bioinformatics expert Tulio de Oliveira was honored with Sikhulile Moyo, his former Ph.D. student, in the Pioneering category. Moyo is the director of the lab in Botswana that was among the first to detect the Omicron variant of the coronavirus that causes COVID-19. The discovery occurred during their routine analysis of the virus genetic materials in positive patient samples. The full sequences of genetic data allowed them to look for any evolutionary changes in the virus currently being transmitted. They were alarmed to see that some of the samples contained heavily mutated viruses far more than previous variants. He reported the sequences to the Botswana Ministry of Health and Wellness, and discussed the matter with de Oliveira in South Africa, who was also seeing strange mutations. Africa publicly reported the genetic and epidemiological findings on the new strain, which was later named Omicron, to the rest of the world.
de Oliveira has worked on viral outbreaks for more than 20 years. These included HIV, Hepatitis B and C, Zika, Yellow Fever, Dengue, Chikungunya, Dengue and SARS-CoV-2, the pandemic coronavirus. He is the former director of the Genomics Program at the Wellcome Trust Africa Centre for Health and Population Studies in South Africa.
de Oliveira is based at one of the seven international partner sites for UWARN, a National Institutes of Health-funded center at the UW. UWARN is a world network of researchers who share their latest information to stay on top of emerging and reemerging pathogens, and their evolving variants. Their goal is to detect potential outbreaks occurring in various parts of the world, information that could assist various agencies in mitigation efforts.
A tribute to the two global health leaders was written for the 2022 TIME100 by John Nkengasong, a Cameroonian virologist who is serving as the first director of the African Centers for Disease Control and Prevention. He applauded them for their remarkable contributions to the understanding of COVID-19 variants in the world.
de Oliveira was one of 10scientists listed in Nature in2021 for their outstanding scientific developments. Hewas also named inMIT Technology Review as one of the leaders of the 10 breakthrough technologies of2022. This same year, he received the Gold Medal Award from the South African Medical Research Council, and, for his contributions to society, the Batho Pele Award from the Government of South Africa.
The human genome team and the COVID-19 variant team join a wide variety of people who have had tremendous influence on the world in government leadership, arts, entertainment, science and medicine, sports, social movements, and many other areas. Some of the others on this years list are Ukrainian President Volodymyr Zelenskyy; Olympic gold-medal figure skater Nathan Chen; European Commission President Ursula von der Leyen; Tanzania President Samia Suluhu Hassan: musician and Oscar-winning filmmaker Ahmir Questlove Thompson, Brazilian indigenous activist and environmentalist Snia Guajajara; U.S. President Joe Biden; Vice Premier of the Peoples Republic of China Sun Chunlan; Excutive Director of the Transgender Education Network of Texas Emmett Schelling; American TV host Oprah Winfrey; and Apple CEO Tim Cook.
Follow @TIME #TIME100 for updates about the list on Twitter and Instagram and at Facebook.com/TIME.
Read the rest here:
Genome and global health scientists on TIME100 - UW Medicine Newsroom
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- Bone-marrow-homing lipid nanoparticles for genome editing in diseased and malignant haematopoietic stem cells - Nature.com - May 23rd, 2024 [May 23rd, 2024]
- Study finds gene variants tied to breast cancer risk in Black women - STAT - May 23rd, 2024 [May 23rd, 2024]
- Active transcription and epigenetic reactions synergistically regulate meso-scale genomic organization - Nature.com - May 23rd, 2024 [May 23rd, 2024]
- The Human Pangenome: A Step Towards More Inclusive Genomic Medicine - Foley & Lardner LLP - May 23rd, 2024 [May 23rd, 2024]
- Genome-wide identification and analysis of epithelial-mesenchymal transition-related RNA-binding proteins and ... - Nature.com - May 23rd, 2024 [May 23rd, 2024]
- AI and CRISPR: Revolutionizing Genome Editing and Precision Medicine - MarkTechPost - May 23rd, 2024 [May 23rd, 2024]
- This AI Paper Introduces Evo: A Genomic Foundation Model that Enables Prediction and Generation Tasks from the Molecular to Genome-Scale -... - May 23rd, 2024 [May 23rd, 2024]
- Inocras and IMBdx Announce Strategic Partnership to Transform Cancer Patient Care in the U.S. - Morningstar - May 23rd, 2024 [May 23rd, 2024]
- Two Notes Genome review could this no-nonsense guitar plugin be all you need? - Guitar.com - May 23rd, 2024 [May 23rd, 2024]
- Research improves multiplex mutagenesis to increase experimental efficiency in plant genome editing - Phys.org - May 23rd, 2024 [May 23rd, 2024]
- Next Gen Diagnostics and Vanderbilt Report the Use of Whole Genome Sequencing to Detect Transmission of Infection ... - Newswire - May 23rd, 2024 [May 23rd, 2024]
- Genomic Enumeration of Antibiotic Resistance in Space (GEARS) Completes Mission Operations - Astrobiology - Astrobiology News - May 23rd, 2024 [May 23rd, 2024]
- Genome Editing Market size is set to grow by USD 7.23 billion from 2024-2028, Rapid technological advancements in ... - PR Newswire - May 23rd, 2024 [May 23rd, 2024]
- The complete plastome sequences of invasive weed Parthenium hysterophorus: genome organization, evolutionary ... - Nature.com - February 18th, 2024 [February 18th, 2024]
- Multi-omic profiling reveals associations between the gut microbiome, host genome and transcriptome in patients with ... - Journal of Translational... - February 18th, 2024 [February 18th, 2024]
- Polymerase Chain Reaction (PCR) - National Human Genome Research Institute - February 18th, 2024 [February 18th, 2024]
- Genomic Time Machine Reveals Secrets of Human DNA - SciTechDaily - February 18th, 2024 [February 18th, 2024]
- 1 Million Unannotated Exons Discovered in the Human Genome - Technology Networks - February 18th, 2024 [February 18th, 2024]
- Hope for the night parrot: bird's full genome has been sequenced - Cosmos - February 18th, 2024 [February 18th, 2024]
- RevIT AAV Enhancer: Rev-up AAV genome production in upstream manufacturing - BioProcess Insider - February 18th, 2024 [February 18th, 2024]
- Multi-omics resources for the Australian southern stuttering frog (Mixophyes australis) reveal assorted antimicrobial ... - Nature.com - February 18th, 2024 [February 18th, 2024]
- Large-scale gene expression alterations introduced by structural variation drive morphotype diversification in Brassica ... - Nature.com - February 18th, 2024 [February 18th, 2024]
- Near-gapless and haplotype-resolved apple genomes provide insights into the genetic basis of rootstock-induced ... - Nature.com - February 18th, 2024 [February 18th, 2024]
- Secrets of Night Parrot unlocked after first genome sequenced - CSIRO - February 18th, 2024 [February 18th, 2024]
- CRISPR gene editing tool gets a revolutionary high-tech upgrade - Earth.com - February 18th, 2024 [February 18th, 2024]
- Ancient retroviruses played a key role in the evolution of vertebrate brains - EurekAlert - February 18th, 2024 [February 18th, 2024]
- Natural selection and genetic diversity maintenance in a parasitic wasp during continuous biological control application - Nature.com - February 18th, 2024 [February 18th, 2024]
- Hopes elusive parrots genome will provide answers - news.com.au - February 18th, 2024 [February 18th, 2024]
- MicroRNA is the master regulator of the genome researchers are learning how to treat disease by harnessing the ... - The Conversation - November 30th, 2023 [November 30th, 2023]
- "Ground-Breaking" Release of World's Largest Whole Genome Resource - Inside Precision Medicine - November 30th, 2023 [November 30th, 2023]
- Pangenome analysis reveals genomic variations associated with domestication traits in broomcorn millet - Nature.com - November 30th, 2023 [November 30th, 2023]
- Global genetic diversity, introgression, and evolutionary adaptation of indicine cattle revealed by whole genome ... - Nature.com - November 30th, 2023 [November 30th, 2023]
- Genome characteristics of atypical porcine pestivirus from abortion cases in Shandong Province, China - Virology Journal - Virology Journal - November 30th, 2023 [November 30th, 2023]
- Correcting modification-mediated errors in nanopore sequencing by nucleotide demodification and reference-based ... - Nature.com - November 30th, 2023 [November 30th, 2023]
- CRISPR-Based "Genome Shredding" Technique Shows Promise in Treating Glioblastoma - Inside Precision Medicine - November 30th, 2023 [November 30th, 2023]
- Genome wide analysis revealed conserved domains involved in the effector discrimination of bacterial type VI secretion ... - Nature.com - November 30th, 2023 [November 30th, 2023]
- TRISH to investigate the effects of spaceflight on the human genome, central nervous system - Odessa American - November 30th, 2023 [November 30th, 2023]
- The venom preceded the stinger: Genomic studies shed light on the origins of bee venom - EurekAlert - November 30th, 2023 [November 30th, 2023]
- Integrating genomic and multiomic data for Angelica sinensis provides insights into the evolution and biosynthesis of ... - Nature.com - November 30th, 2023 [November 30th, 2023]
- Genetic diversity and ancestry of the Khmuic-speaking ethnic groups ... - Nature.com - September 21st, 2023 [September 21st, 2023]
- Researchers to Apply Genome Analysis to Childhood Cancers; Goal ... - The Japan News - September 21st, 2023 [September 21st, 2023]
- How Bats' Genomes May Help Them Avoid Cancer and Survive ... - Technology Networks - September 21st, 2023 [September 21st, 2023]
- Longitudinal genomic surveillance of carriage and transmission of ... - Nature.com - September 21st, 2023 [September 21st, 2023]
- Whole genomes from bacteria collected at diagnostic units around ... - Nature.com - September 21st, 2023 [September 21st, 2023]
- Genome-wide identification of lncRNA & mRNA for T2DM | PGPM - Dove Medical Press - September 21st, 2023 [September 21st, 2023]
- Tasmanian tiger RNA is first to be recovered from an extinct animal - Nature.com - September 21st, 2023 [September 21st, 2023]
- Loneliness and depression: bidirectional mendelian randomization ... - Nature.com - September 21st, 2023 [September 21st, 2023]
- Rome Therapeutics adds $72 million to Series B round to harness ... - OutSourcing-Pharma.com - September 21st, 2023 [September 21st, 2023]
- Mystery of 'living fossil' tree frozen in time for 66 million years finally ... - Livescience.com - September 21st, 2023 [September 21st, 2023]
- Why the human genome could be healthcares holy grail - Yahoo Finance - May 4th, 2023 [May 4th, 2023]
- Scientists Compare Genomes of 240 Mammals to Understand Human DNA - The New York Times - May 4th, 2023 [May 4th, 2023]
- Genomes From 240 Mammalian Species Help Explain 100 Years Of Evolution And Human Disease - ABP Live - May 4th, 2023 [May 4th, 2023]
- 'Deletions' from the human genome may be what made us human - Yale News - May 4th, 2023 [May 4th, 2023]
- GeneDx Adds Buccal Swab as Non-Invasive Whole Genome ... - GlobeNewswire - May 4th, 2023 [May 4th, 2023]
- Whole-genome sequencing used to track down genes behind familial glioma - Medical Xpress - May 4th, 2023 [May 4th, 2023]
- Wiggly proteins guard the genome: Dynamic network in the pores of ... - Science Daily - May 4th, 2023 [May 4th, 2023]
- Genome-Wide Splicing Quantitative Expression Locus Analysis ... - Cancer Discovery - May 4th, 2023 [May 4th, 2023]
- Digital Genome Market is expand at a CAGR of 8.6% to reach USD ... - Digital Journal - May 4th, 2023 [May 4th, 2023]
- High School Students Learn the Basics of Base Editing to Cure GFP ... - University of California San Diego - May 4th, 2023 [May 4th, 2023]
- Genomic researchers gain access to CSIRO's AI-powered data ... - Microsoft - May 4th, 2023 [May 4th, 2023]
- Archaic hominin traits through the splicing lens - Nature.com - May 4th, 2023 [May 4th, 2023]
- Critical bug in genome sequencing device scores '10' on CVSS ratings - SC Media - May 4th, 2023 [May 4th, 2023]
- Novel Genomic Approach Ensures Better Diagnosis of Hereditary ... - Technology Networks - May 4th, 2023 [May 4th, 2023]
- Intellia Therapeutics: Leading the Way in Revolutionary Genome ... - Best Stocks - May 4th, 2023 [May 4th, 2023]
- Visual tracking of viral infection dynamics reveals the synergistic ... - Nature.com - May 4th, 2023 [May 4th, 2023]
- Genome | Genome LLC | United States - March 31st, 2023 [March 31st, 2023]
- Belarus: EU and WHO deliver equipment for research of genomes of infectious disease agents - EIN News - February 24th, 2023 [February 24th, 2023]
- Gene vs. genome: Definition, function, and impact - January 30th, 2023 [January 30th, 2023]
- Big cog in the wheel: As Covid worries reappear, Insacogs genome sequencing ability must be aided by govts - Times of India - December 25th, 2022 [December 25th, 2022]
- CapitalGainsReport Sector Spotlight: Healthcare Penny Stocks On The Move (ARDX, WHSI, BNGO) - Marketscreener.com - November 25th, 2022 [November 25th, 2022]
- Genome Insight and Kun-hee Lee Child Cancer & Rare Disease Project Team of SNUH (Seoul National University Hospital) Made an Agreement About a... - November 23rd, 2022 [November 23rd, 2022]
- Genome-wide association study reveals distinct genetic associations related to leaf hair density in two lineages of wheat-wild relative Aegilops... - October 19th, 2022 [October 19th, 2022]
- The Global Genomics Market to Exhibit Growth at a CAGR of 16.90% During the Forecast Period (20222027) | DelveInsight - Yahoo Finance - October 19th, 2022 [October 19th, 2022]
- Illumina and GenoScreen Partner to Expand Access to Genomic Testing for Multidrug-Resistant Tuberculosis - PR Newswire - October 19th, 2022 [October 19th, 2022]
- Superresolution Method Poised to Better Gene Function Understanding - Photonics.com - October 19th, 2022 [October 19th, 2022]
- Genome-centric analysis of short and long read metagenomes reveals uncharacterized microbiome diversity in Southeast Asians - Nature.com - October 15th, 2022 [October 15th, 2022]
- How a New Battery Data Genome Project Will Use Vast Amounts of Information to Build Better EVs - InsideClimate News - October 15th, 2022 [October 15th, 2022]
- Scientists Reconstruct the Genome of the 180-Million-Year-Old Common Ancestor of All Mammals - SciTechDaily - October 15th, 2022 [October 15th, 2022]
- Combining OSMAC, metabolomic and genomic methods for the production and annotation of halogenated azaphilones and ilicicolins in termite symbiotic... - October 15th, 2022 [October 15th, 2022]