In the early 1990s, Tom Perls met two people who would change his life. Perls, then a gerontology fellow at Harvard Medical School, was visiting Bostons Hebrew Rehabilitation Center for Ageing and needed to see a couple of patients who just happened to be over 100. But he couldnt find them in their rooms. He eventually tracked down one patient, a 103-year-old woman. She was busy playing Chopin and Mozart on the piano. Perls other patient, a 101-year-old former tailor, was discovered in the occupational health room mending his housemates clothes.
They totally surprised me and thats when the epiphany happened, says Perls, who is now based at Boston University. These folks seemed to be ageing incredibly slowly compared to other people. He wanted to figure out their longevity secrets and vowed to find as many other centenarians as he could. The project became the New England Centenarian Study, the worlds largest study of exceptionally old people.
Centenarians are less rare than they used to be. In the UK, there were 15,120 centenarians alive in 2020 (almost double the figure in 2002), according to the Office for National Statistics. But becoming eligible for a birthday letter from the Queen is still a remarkable feat. We spoke to longevity experts about the science that might help all of us get there and the misconceptions about ageing you should stop believing.
Myth: Theres an evolutionary reason for ageing
To figure out how to slow (or even stop) ageing, we need to know why our bodies do it in the first place. But biologist Cathy Slack from Aston University, says scientists just arent sure yet. From a purely theoretical perspective, theres no beneficial reason to age, she says. We used to think ageing resulted from a buildup of reactive oxygen species (free radicals) which caused molecular damage, but recent research suggests this is unlikely to be the full story. The current most popular explanation is that ageing is an unwanted side effect of biological processes that promote growth and reproduction in our younger years, says Slack.
After a certain point, the same mechanisms that once made us fitter start making us sicker and the body fails to turn them off. Scientists call this the hyperfunction theory of ageing. Its like a tap being left on, says Slack. You need to fill the bath, but if you leave the tap on, the water overflows and you flood your bathroom.
Myth: Old age automatically means poor health
Findings from Perls study of centenarians showed the pianist and the tailor werent outliers. People who make it to 100 arent just long-living, they tend to avoid serious illness until the final chapter of their lives. His participants medical histories suggest there are three broad categories of centenarian. Around 43 percent are delayers who dont exhibit age-related diseases until they reach their eighties. Another 42 percent are survivors who live with chronic disease from their 60s and 70s but it doesnt kill them. The remaining 15 percent or so are escapers - those with no clinically demonstrable disease at 100 years and over.
Its true that age is a major risk factor for many serious illnesses such as heart disease, dementia and diabetes. But Perls believes the old adage the older you get, the sicker you get is false. He prefers to think of it as the older you get, the healthier youve been.
Myth: Theres nothing you can do to prevent death
Its likely that centenarians, and especially super-centenarians (people who live to 110 and over) have genetic variants which protect them from age-related disease, says Perls. But genetics isnt the full picture when it comes to longevity. In fact, research suggests only about 25 per cent of the variation in human lifespan is down to genes. Health-related behaviours and the environment make up the lions share.
Just look to Californias Seventh Day Adventists, says Perls. People from this Christian denomination tend to live up to a decade longer than the average Californian. They dont smoke, drink, or eat meat, which might explain it. Perls thinks most of us could make it into our nineties simply by following a reasonably healthy lifestyle from middle age.
Nutritional epidemiologist Frank Hu, from Harvard TH Chan School of Public Health, agrees. His research, published in the British Medical Journal in 2020, uncovered five lifestyle factors that could gift you ten extra years of life. People whod never smoked, didnt drink much, had a normal BMI, exercised for around 30 minutes a day, and ate a high-quality diet expanded not only their lifespan but also the number of years they lived without serious diseases, such as diabetes, heart disease and cancer. The findings are cause for optimism, says Hu. You dont need to go vegan or run a marathon. Small healthy tweaks might extend your life significantly.
Stopping senescence could be key to living long
Other longevity research zooms in on a type of cell that accumulates in our tissues as we get older. These cells no longer multiply, but they also refuse to die. Biologists once dismissed these zombies, called senescent cells, as irrelevant to health and disease. But some researchers now believe manipulating them could be key to better ageing. Biochemist Judith Campisi from the Buck Institute for Research on Aging in California found senescent cells ooze inflammatory proteins that damage tissue and halt surrounding cells from carrying out their normal processes. Removing them from the body might therefore slow down age-related decline.
In James Kirklands laboratory at Mayo Clinic, Minnesota, mice given drugs called senolytics, which selectively kill these senescent cells, survived for longer than normal and showed delayed onset of multiple conditions usually associated with ageing. Several biotech companies, such as Unity Biotechnology, have since set their sights on senolytics as a potential fountain of youth.
Continued here:
The science that could help you live to 100 - Wired.co.uk
- How dogs are paving the way for human longevity drugs - Longevity.Technology - April 12th, 2024 [April 12th, 2024]
- Innovative Approaches to Improving Human Longevity - Securities.io - April 12th, 2024 [April 12th, 2024]
- Top 5 Companies Offering Solutions to Increased Human Longevity - Securities.io - April 12th, 2024 [April 12th, 2024]
- Morning Medical Update: Gut bacteria and longevity; People with ... - Medical Economics - June 12th, 2023 [June 12th, 2023]
- Artificial Intelligence and the Aging Process: A Match Made for ... - Down to Game - June 12th, 2023 [June 12th, 2023]
- Saint Bernard Lifespan: How Long Do Saint Bernards Live? - AZ Animals - June 12th, 2023 [June 12th, 2023]
- 'Human Resources' Was Poised to Be Netflix's Longest-Running ... - PRIMETIMER - June 12th, 2023 [June 12th, 2023]
- Early Life Adversity Doesn't Affect Gorillas Like Other Species - The Good Men Project - June 12th, 2023 [June 12th, 2023]
- Wellness luminaries, experts to meet in KK - The Borneo Post - June 12th, 2023 [June 12th, 2023]
- I grew up with hazardous smoke from forest fires in Asia. Here's what ... - Morningstar - June 12th, 2023 [June 12th, 2023]
- Workplace Networks Are More Important than Promotions to Engage ... - GlobeNewswire - June 12th, 2023 [June 12th, 2023]
- Accenture staff working at Google training AI move to unionise - The Australian Financial Review - June 12th, 2023 [June 12th, 2023]
- Hair Wigs and Extension Market Size to Grow by USD 5.26 billion from 2021 to 2026, Growth Driven by Technologi - Black Enterprise - April 10th, 2023 [April 10th, 2023]
- Want to age like a fine wine? Here are some tips for longevity and feeling younger - The Indian Express - February 18th, 2023 [February 18th, 2023]
- Human body | Organs, Systems, Structure, Diagram, & Facts - January 27th, 2023 [January 27th, 2023]
- Human | Avatar Wiki | Fandom - January 27th, 2023 [January 27th, 2023]
- Calorie Restriction and Fasting Diets: What Do We Know? - January 4th, 2023 [January 4th, 2023]
- Emma Thompson On Longevity Of Holiday Fave Love Actually But It Is SEX Actually That Is Earning Her Awards Buzz In Leo Grande - Deadline - December 26th, 2022 [December 26th, 2022]
- Heads or tails: What statistical models tell us about the probability of living beyond 110 - The Conversation - December 12th, 2022 [December 12th, 2022]
- LinkedIn founder and VC Reid Hoffman says human amplification via A.I. will revolutionize large enterprises in the next five years - Fortune - December 12th, 2022 [December 12th, 2022]
- Human hibernation is possible and could boost longevity | New Scientist - December 2nd, 2022 [December 2nd, 2022]
- Home - Human Longevity Institute - October 23rd, 2022 [October 23rd, 2022]
- Exercise: 7 benefits of regular physical activity - Mayo Clinic - October 23rd, 2022 [October 23rd, 2022]
- Life expectancy - Wikipedia - October 13th, 2022 [October 13th, 2022]
- Life Expectancy - Our World in Data - October 13th, 2022 [October 13th, 2022]
- The Longevity Investors Conference Gstaad brought together longevity experts and deep-pocketed investors - Cointelegraph - October 13th, 2022 [October 13th, 2022]
- The Search for a Pill That Can Help Dogsand HumansLive Longer - WIRED - October 13th, 2022 [October 13th, 2022]
- Aging of the Heart Correlates With a Poor Gut Microbiome - Lifespan.io News - October 13th, 2022 [October 13th, 2022]
- Aditxt, Inc. (Nasdaq: ADTX) Announces Development and Publication of a Mathematical Model for Predicting Longevity and Variations of Immune Response... - October 13th, 2022 [October 13th, 2022]
- FOXO Technologies Announces First Distribution Partner and Begins Product Rollout in California; Expands Executive Team With Insurance Industry Talent... - October 13th, 2022 [October 13th, 2022]
- A conversation with Holocaust scholar Dr. Irving Berkowitz - South Florida Sun Sentinel - October 13th, 2022 [October 13th, 2022]
- Nine postdoctoral fellowships in aging research awarded by the Glenn Foundation for Medical Research and AFAR - EurekAlert - October 13th, 2022 [October 13th, 2022]
- The 5 Wellness Habits That Slow Down Aging, Science Reveals Eat This Not That - Eat This, Not That - October 13th, 2022 [October 13th, 2022]
- Winning Federal Contracts on the Top 20 Contract Vehicles - Bloomberg Government - October 13th, 2022 [October 13th, 2022]
- Lawrence Austin promoted to rank of colonel - Winona Times - October 13th, 2022 [October 13th, 2022]
- The longevity dividend: Work in an era of 100-year lives - October 2nd, 2022 [October 2nd, 2022]
- Retirement Savings Calculator - Northwestern Mutual - October 2nd, 2022 [October 2nd, 2022]
- Clues to Human Longevity Unearthed in Largescale Mouse Genetic Study - Genetic Engineering & Biotechnology News - October 2nd, 2022 [October 2nd, 2022]
- Can we find ways to live beyond 100? Millionaires are betting on it. - MIT Technology Review - October 2nd, 2022 [October 2nd, 2022]
- Restrict Calories to Boost Immune Function - The Epoch Times - October 2nd, 2022 [October 2nd, 2022]
- The Black Progress Index: Examining the social factors that influence Black well-being - Brookings Institution - October 2nd, 2022 [October 2nd, 2022]
- Kevin Williamson on Scream 6 and Franchise Longevity - Bleeding Cool News - October 2nd, 2022 [October 2nd, 2022]
- 507-Year-Old Clam May Be the World's Oldest Living Being - History of Yesterday - October 2nd, 2022 [October 2nd, 2022]
- I should look forward to early retirement, but I think I'm dreading it - CBC.ca - October 2nd, 2022 [October 2nd, 2022]
- International Coffee Day 2022: How The Beloved Brew Helps Fight Cancer, Kidney Disease And Depression - ABP Live - October 2nd, 2022 [October 2nd, 2022]
- Corey Feldman And Jamison Newlander Talk The Lost Boys And The Birth Of The Two Coreys - Forbes - October 2nd, 2022 [October 2nd, 2022]
- Proven Levels of Human Longevity | NextBigFuture.com - September 11th, 2022 [September 11th, 2022]
- Prolonging healthspan by delaying ageing -- NUHS opens Singapore's first Centre for Healthy Longevity to increase healthy lifespan of Singapore... - September 11th, 2022 [September 11th, 2022]
- What is the Secret to Longevity in Real Estate? - CandysDirt.com - Candy's Dirt - September 11th, 2022 [September 11th, 2022]
- Jeff Stukey & Jay Olshansky, Ph.D with Wealthspan Advisors, Interviewed on the Influential Entrepreneurs Podcast Discussing How Aging Science... - September 11th, 2022 [September 11th, 2022]
- The Queen of the World - The Atlantic - September 11th, 2022 [September 11th, 2022]
- THR Icon: At 100, Norman Lear Looks Back (And Ahead) at Whats Changed Since the Maude Abortion Episode - Hollywood Reporter - September 11th, 2022 [September 11th, 2022]
- TIFF 2022: The Colour of Ink Review - ThatShelf.com - September 11th, 2022 [September 11th, 2022]
- Should Age Be on the Ballot? - Next Avenue - September 11th, 2022 [September 11th, 2022]
- Was The Spring Water At Balmoral Castle The Secret To Elizabeth II's Longevity? - Nation World News - September 11th, 2022 [September 11th, 2022]
- A complete guide to the health benefits of nuts europeantimes.news - The European Times - September 11th, 2022 [September 11th, 2022]
- Debut Launches its Bio2Consumer Platform to Become the Leader in Vertically Integrated Synthetic Biology - PR Web - September 11th, 2022 [September 11th, 2022]
- Rapamycin Drug Used in Cancer Therapy Found to Increase Human Lifespan [Study] - Nature World News - August 30th, 2022 [August 30th, 2022]
- Eating Healthy: Why Eating Grapes Would Increase Lifespan | The Guardian Nigeria News - Nigeria and World News Guardian Life The Guardian Nigeria... - August 30th, 2022 [August 30th, 2022]
- Beauty Bets on Longevity WWD - WWD - August 30th, 2022 [August 30th, 2022]
- Analysis of the impact of success on three dimensions of sustainability in 173 countries | Scientific Reports - Nature.com - August 30th, 2022 [August 30th, 2022]
- You might have glowing skin in no time by making few easy changes to your skincare routine - TDPel Media - August 30th, 2022 [August 30th, 2022]
- Nucleai Appoints New Head of Pathology to Support Expansion in Biopharmaceutical and Clinical Markets - Business Wire - August 8th, 2022 [August 8th, 2022]
- Daily AI Roundup: Biggest Machine Learning, Robotic And Automation Updates - AiThority - August 8th, 2022 [August 8th, 2022]
- Prolonged and intense heatwave affecting parts of western and northern Europe breaks temperature records; globally, July 2022 was one of three warmest... - August 8th, 2022 [August 8th, 2022]
- YLEM: Augmenting sustainable futures through material exploration and testing - STIRworld - August 8th, 2022 [August 8th, 2022]
- Do you want to live forever? Big Tech and the quest for eternal youth - The New Statesman - August 6th, 2022 [August 6th, 2022]
- This startup wants to copy you into an embryo for organ harvesting - MIT Technology Review - August 6th, 2022 [August 6th, 2022]
- Renewal Bio Acquires Breakthrough Stem Cell Technology With Applications in Infertility and Longevity - Benzinga - August 6th, 2022 [August 6th, 2022]
- Get married or get a degree to live longer says study, debunking theories of womens longevity over men - Times Now - August 6th, 2022 [August 6th, 2022]
- Nucleai Appoints New Head of Pathology to Support Expansion in Biopharmaceutical and Clinical Markets - StreetInsider.com - August 6th, 2022 [August 6th, 2022]
- Some species are immortal but dying of old age is humanity's secret weapon - The Telegraph - August 6th, 2022 [August 6th, 2022]
- Opinion: Changing When and How Much We Eat May Extend Health Span - The Scientist - August 6th, 2022 [August 6th, 2022]
- Vieroots uses genome testing to win over a growing tribe of wellness enthusiasts - YourStory - August 6th, 2022 [August 6th, 2022]
- Herbs radiate and give you youthful skin - The Hans India - August 6th, 2022 [August 6th, 2022]
- How Pop Culture, Politics, Science, and Business Got So Old - The Atlantic - August 6th, 2022 [August 6th, 2022]
- John Hood: How to read this column | Columnists | journalnow.com - Winston-Salem Journal - August 6th, 2022 [August 6th, 2022]
- How Long Is The Human Lifespan? Here's What Studies Have Found | mindbodygreen - mindbodygreen - July 31st, 2022 [July 31st, 2022]
- Employees are livingand workinglonger. CEOs are introducing initiatives like phased retirements to harness the longevity economy - Fortune - July 31st, 2022 [July 31st, 2022]
- Why Do We Get Old, and Can Aging Be Reversed? - Quanta Magazine - July 31st, 2022 [July 31st, 2022]