Monthly Archives: May 2024

Cystic fibrosis: global clinical trials landscape and treatments – Clinical Trials Arena

Posted: May 25, 2024 at 5:09 pm

Cystic fibrosis (CF) is a genetic disorder caused by mutations in the CFTR gene, affecting chloride and bicarbonate transport in cells. This leads to thick mucus secretions in organs like the lungs and pancreas, causing blockages and health complications in the respiratory and digestive systems. Before the 1980s, many CF patients didnt survive past their 20s. Recent advancements have gradually raised life expectancy, with a projected 75% increase in adult cystic fibrosis population by 2025.

CF impacts an estimated 162,400 individuals worldwide, with a predominant occurrence among the White population. However, recent evidence indicates its presence in regions like the Middle East, Asia, and Latin America, although at lower rates. In the North American region, the US leads in cystic fibrosis cases, while Canada shows a higher prevalence rate per CF patient population. Europe sees variation, with the UK leading in prevalence, while Belgium and Switzerland show high rates despite lower CF patient populations.

In the Asia-Pacific, Australia and New Zealand report a significant number of cystic fibrosis cases, demanding strong healthcare initiatives. The rest of the world exhibits disparities, with Brazil leading in cystic fibrosis population and South Africa and Egypt following next, although with a moderate number of cases. These findings emphasise the importance of personalised approaches and strong healthcare initiatives to tackle cystic fibrosis on a global scale.

Since 2018, the biotech and biopharma industry has initiated over 450 CF trials. Europe and North America have conducted the most trials, followed by Asia Pacific, while the rest of the world contributes moderately. The US leads in North America, with the UK and Germany prominent in Europe. Significant research efforts are also seen in Australia in the Asia-Pacific region, and Israel in the Middle East. When it comes to patient recruitment trends, Europe shows shorter recruitment durations and faster patient recruitment rates in comparison to the US and Asia-Pacific.

While cystic fibrosis lacks a cure, modern treatments prolong lives through comprehensive management, including nutritional support, airway clearance techniques, and targeted drugs such as CFTR modulators. CFTR modulators enhance lung function by targeting the defective CFTR protein, though their effectiveness depends on gene mutations. They have transformed cystic fibrosis treatment by tackling the root cause of the disease.

The cystic fibrosis treatment market offers diverse products from companies like Advanz Pharma Corp. Ltd., Novartis AG, Pari GmbH, Pharmaxis Ltd., and Vertex Pharmaceuticals Inc., covering small molecules, enzymes, biologics, and stem cells. Vertex Pharmaceuticals Inc. is conducting Phase III trials for small molecule therapies targeting CFTR protein, reflecting ongoing efforts to improve cystic fibrosis treatment. This and several other research and development initiatives represent a comprehensive approach by the companies involved in their pursuit to address cystic fibrosis treatment complexities and enhance patient outcomes.

In conclusion, cystic fibrosis remains a global health challenge, but recent treatment advances have improved patient outcomes compared to the previous years. Disparities in global prevalence rates and healthcare infrastructure highlight the need for tailored approaches and strong healthcare initiatives. The increase in cystic fibrosis clinical trials and diverse therapeutic options reflects ongoing efforts to address cystic fibrosis complexities and enhance patient well-being. Collaboration among researchers, healthcare providers, and pharmaceutical companies holds promise for further progress in its management and care.

Rare disease clinical studies require a full-service CRO with expertise in patient enrollment, site selection, access to patient registries, and comprehensive global regulatory knowledge for rare and orphan disease trials.

Novotech, a global CRO, has extensive experience in rare disease studies, including cystic fibrosis, Alport syndrome, and Duchenne muscular dystrophy. With numerous trials in rare disease indications, Novotech is dedicated to advancing biotech research and treatments. Discover more about cystic fibrosis research by downloading the comprehensive disease report below.

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Inter Miami CF Claims Double Win at 17th Annual Sports Business Awards: Deal of the Year & Team of the Year – Inter Miami CF

Posted: at 5:09 pm

Inter Miami CF took home two prestigious honors at the 17th Annual Sports Business Awards on Wednesday night in New York City, with the Club having the standout performance of the evening among sports entities. With the signing of Lionel Messi in July 2023 as the catalyst, the Club was recognized with Deal of the Year and Team of the Year honors.

The pair of honors underscores the commitment of Inter Miami Ownership to the Clubs motto, Freedom to Dream. Managing Owner Jorge Mas, and Co-Owners Jose Mas, and David Beckham fulfilled the Freedom to Dream ethos by signing world-class players to compete for Inter Miami CF to represent the essence of South Florida.

Our Club is built on dreams, big dreams said Inter Miami CF Managing Owner Jorge Mas. I, together with Jose and David, promised our fans that the worlds best players would call Inter Miami home. We delivered on our promise and are honored to dedicate these recognitions to our fans whom always believed in us and this is only the beginning.

Deal of the Year Winner: Inter Miami CF Signs Lionel Messi The signing of eight-time Ballon dOr winner, Lionel Messi, transformed North American sports and catapulted Inter Miami into a global phenomenon overnight. Messis arrival at Inter Miami elevated the team's on-field performance immediately, ignited a commercial surge, and helped transform Inter Miami into a reference point for ftbol globally.

The Deal of the Year Award was presented by Super Bowl Champion, and former National Football League player, Jason McCourty. Inter Miami CF Chief Business Officer, Xavier Asensi accepted the award on behalf of the Club.

Sports Team of the Year Winner: Inter Miami CF Just moments after receiving the Deal of the Year Award, Asensi returned to the stage alongside a group of Inter Miami CF members to accept the Team of the Year Award.

The second recognition underscores not just the monumental feat of signing Messi, but also the Club's strategic vision in leveraging the unprecedented moment in Inter Miami history and propelling the Club to exponential heights. The prestigious honor was presented by the legendary Billie Jean King.

Launched in 2008, the Sports Business Awards were established by Sports Business Journal to celebrate excellence in the business of sports. For more information on the distinguished Awards, please visit http://www.sportsbusinessjournal.com.

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The Defeat that Rocks CF Montral and Elevates Forge FC – MLS Multiplex

Posted: at 5:09 pm

CF Montral's elimination in the quarterfinals of the 2024 Canadian Championship against Forge FC marked a moment of reflection for the club and its supporters. With an aggregate score of 3-2, after a 2-1 defeat in the second leg at home, at Stade Saputo, the match exposed the weaknesses of a team that aimed for a sixth national title and a spot in the 2025 Concacaf Champions League. CF Montral took to the field with the responsibility to overturn the 1-1 draw achieved in the first leg, but was quickly stunned by Forge FC. Daniel Parra and Kwasi Poku put the visiting team ahead with two goals in the first 30 minutes, a tough blow to coach Hernn Losada's plans.

The two-hour delay due to bad weather seemed to have given CF Montral a new lease of life, as they returned from halftime with a more aggressive stance. The team managed to reduce the deficit with a goal from Victor Wanyama in the 66th minute. However, the inability to find the second goal needed to force extra time or secure a victory revealed a lack of offensive efficiency that has been recurring throughout the season. The quarterfinal elimination is a significant setback for a club with the ambitions of CF Montral. Besides missing out on the chance to contend for the national title, the defeat means the club won't have the opportunity to compete in the Concacaf Champions League in 2025.

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Forge FC's victory represents a significant milestone for the Canadian Premier League (CPL) and for the club itself, which has been establishing itself as an emerging force in Canadian soccer. The convincing performance against a Major League Soccer (MLS) team like CF Montral shows that CPL is becoming a more competitive league and capable of forming teams that can compete at higher levels. Daniel Parra and Kwasi Poku stood out not only for their goals but also for how they orchestrated the game, demonstrating skill and determination. Forge FC's success is not just a tactical victory but also a sign that Canadian soccer is diversifying and strengthening its foundations.

CF Montral's defeat should serve as a wake-up call for the club. Management and the coaching staff need to deeply assess what went wrong and how these mistakes can be corrected. The lack of depth in the squad, defensive lapses, and inefficiency in attack are issues that need to be addressed if the club wants to return to being a dominant force on the national scene. For Forge FC, this victory could be a catalyst for a bright future. The confidence gained from this win can propel the team to new heights. The club has shown that it has the talent and organization necessary to challenge MLS teams, which bodes well for the future of Canadian soccer.

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CF Montreal vs Nashville prediction, preview, team news and more | MLS 2024 – Sportskeeda

Posted: at 5:09 pm

Major League Soccer returns with a fresh set of fixtures, as CF Montreal and Nashville square off at the Saputo Stadium on Saturday (May 25). While the Boys in Gold appear to have hit their stride in recent weeks, the hosts head into the weekend on a run of three defeats.

Montreal suffered a quarterfinal exit from the Canadian Championship on Wednesday, as they fell to a shock 2-1 loss to Canadian Premier League side Forge FC at home.

Laurent Courtois men have lost four games on the spin and are winless in eight games across competitions since a 2-1 victory over FC Cincinnati on April 14. With 12 points from 13 games, Montreal are 13th in the Eastern Conference, three points and two places below Nashville.

The visitors were denied consecutive wins for the first time this season last time out, as they were held to a 1-1 draw by Atlanta United at Geodis Park. With that result, Rumbani Munthalis men have gone unbeaten in four home games, winning two, since a 2-1 loss to Philadelphia Union in April.

Nashville holds the upper hand in the fixture, having won six of their last nine meetings. Montreal have picked up one win in that period.

CF Montreal Form Guide: L-L-L-L-D

Nashville Form Guide: D-W-L-W-D

Montreal will have to cope without a host of key players, as they continue their spells on the injury table.

Injured: Mason Toye, Lassi Lappalainen, Ousman Jabang, Raheem Edwards, Nathan-Dylan Saliba, Josef Martinez, Matias Coccaro, Kwadwo Opoku

Suspended: None

Dru Yearwood, Randall Leal and Lukas MacNaughton have been ruled out through injuries.

Injured: Dru Yearwood, Randall Leal, Lukas MacNaughton

Suspended: None

CF Montreal (3-4-3): Jonathan Sirois; George Campbell, Joel Waterman, Fernando Alvarez; Ruan, Samuel Piette, Mathieu Choiniere, Ariel Lassiter; Jules-Anthony Vilsaint, Bryce Duke, Sunusi Ibrahim

Nashville (4-4-2): Joe Willis; Shaq Moore, Walker Zimmerman, Jack Maher, Daniel Lovitz; Tyler Boyd, Anibal Godoy, Sean Davis, Jacob Shaffelburg; Hany Mukhtar, Sam Surridge

Montreal and Nashville have endured a slow start to the season and find themselves separated by just three points at the bottom end of the table. Expect both sides to cancel out each other and settle for a share of the spoils.

Prediction: Montreal 1-1 Nashville

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Nashville tries to end road losing streak against CF Montreal – Yahoo Canada Sports

Posted: at 5:09 pm

Nashville SC (3-4-6, 10th in the Western Conference) vs. CF Montreal (3-7-3, 12th in the Eastern Conference)

Montreal, Quebec; Saturday, 7:30 p.m. EDT

BETMGM SPORTSBOOK: LINE Montreal +151, Nashville SC +173, Draw +222; over/under is 2.5 goals

BOTTOM LINE: Nashville visits CF Montreal aiming to break a three-game road slide.

Montreal is 1-2-1 at home. Montreal has scored 17 goals while allowing 31 for a -14 goal differential.

Nashville is 0-3-1 on the road. Nashville has a 1-2 record in matches decided by one goal.

Saturday's game is the second time these teams meet this season. Nashville won the last meeting 4-1.

TOP PERFORMERS: Matias Coccaro has three goals and one assist for Montreal. Ariel Lassiter has two goals and one assist over the past 10 games.

Sam Surridge has scored five goals for Nashville. Jacob Shaffelburg has three assists over the past 10 games.

LAST 10 GAMES: Montreal: 1-7-2, averaging 1.2 goals, 3.6 shots on goal and 4.4 corner kicks per game while allowing 2.8 goals per game.

Nashville: 3-4-3, averaging 1.4 goals, 3.9 shots on goal and 5.0 corner kicks per game while allowing 1.7 goals per game.

NOT EXPECTED TO PLAY: Montreal: Ousman Jabang (injured), Nathan-Dylan Saliba (injured), Kwadwo Opoku (injured), Matias Coccaro (injured), Raheem Edwards (injured), Lassi Lappalainen (injured), Josef Martinez (injured).

Nashville: Lukas MacNaughton (injured), Randall Leal (injured).

___

The Associated Press created this story using technology provided by Data Skrive and data from Sportradar.

The Associated Press

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‘Fragile’ CF Montreal hopes to break out of slump against Nashville SC – Moose Jaw Today

Posted: at 5:09 pm

MONTREAL CF Montreal fans have had enough and captain Samuel Piette understands why. Montreal is struggling, winless in its last eight games.

MONTREAL CF Montreal fans have had enough and captain Samuel Piette understands why.

Montreal is struggling, winless in its last eight games. In the last week, the club lost 5-1 in a derby match at Toronto FC before falling 2-1 to lower-tier Forge FC of the Canadian Premier League to drop out of the Canadian Championship quarterfinals.

The supporters' sections performed a silent protest during the first half against Forge. By the end of the match, they were booing and exchanging words with Piette with one set of fans holding a white tarp with "INACCEPTABLE" written across it.

"They expressed their displeasure about the desire, the commitment," Piette said Friday, calling the interaction a good discussion. "For them, results are important, but secondary. It's more about the effort, and theyre right."

Montreal (3-7-3) will try to get back on track Saturday when it hosts Nashville SC (3-4-6) at Saputo Stadium.

Piette said he tried to remind the fans that as difficult as it is for them, the players are taking it just as hard.

"We're not proud of ourselves we want to try to turn things around," he said. Its difficult because our confidence is not at its highest.

"We feel like we're walking on eggshells because our confidence is so fragile right now."

Montreal last won a match at its home opener on April 25 and has been outscored 20-9 in all competitions since.

Injuries have taken a toll on a club with the second-lowest payroll in MLS. Eight players are out, including top forwards Matias Coccaro and Josef Martinez.

Piette wouldn't use that as an excuse and said some players arent giving enough effort.

The 29-year-old said the team is giving opponents too much space and offering up easy chances that Montreal hasnt in turn been able to generate for itself. Hes also sensed that his squad lets itself down after conceding a first goal, allowing opponents to quickly get a second and third.

"I dont think its all 11 players, Piette said. There are some who have love for this club, who sweat for the shirt no matter how we play performance-wise. There are some right now honestly who are performing less well, there are players who are less consistent.

"Theres a lack of intensity, in pressing, in challenges, in aggressiveness towards the ball carrier," he added. "We're missing a bit of putting on our work boots, our helmets, doing the dirty work. Lately thats what's missing, and we need to get that back."

Amid the run of bad form, the club is also in turmoil off the pitch.

Montreal parted ways with sporting officer Olivier Renard on May 9, less than two weeks after news surfaced that team MVP Mathieu Choiniere reportedly requested a trade amid a contract dispute, raising questions about the clubs chain of command. Renard said last week the two sides were no longer on the same page.

Piette said he feels especially bad for first-year head coach Laurent Courtois amid the difficult time at the club.

The top coaching job in Montreal has been a revolving door with Courtois becoming the 10th head coach appointed since the team entered MLS in 2012.

After a strong start to the season, the 45-year-old from France is suddenly managing a sinking ship thats conceded the second-most goals in MLS, but he's trying to stay positive.

"The experience I have here coaching this group, in this club, for the people who support us, is a privilege every day even if the last few weeks have been complicated, Im living a dream, Courtois said. But it hurts, it hurts for the supporters."

Courtois has repeatedly taken the blame for Montreals shortcomings.

"Its my job to find a way to make these lows less low," he said. "But Im also sure of what these guys are capable of doing well.

"I'm sure there will be a reaction and in the coming weeks we will be able to rebuild on positive things."

Meanwhile, Nashville (3-4-6) has lost three straight on the road and fired head coach Gary Smith last week, albeit after a 2-0 home victory over Toronto. Nashville also contributed to Montreals misery with a 4-1 win on May 4.

On Saturday night, Montreal hopes to have the fans behind the team as it seeks revenge.

"We need them, but at the same time we understand that weve disappointed them a lot," Piette said. "Its up to us to earn their trust."

This report by The Canadian Press was first published May 24, 2024.

Daniel Rainbird, The Canadian Press

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CF Montreal v Nashville SC: Munthali aiming to get Coyotes back on track – sportsmax.tv

Posted: at 5:09 pm

Nashville SC interim head coach Rumbani Munthali aims to get a more recognizable look about the team as he prepares for his second game in charge against CF Montreal.

Gary Smith, who led Nashville for seven years, made a shock exit following their 2-0 win over Toronto FC on May 16, with Munthali stepping up from player development coach to take his place.

Nashvilles first game under him ended in a 1-1 draw with Atalanta United on Saturday, leaving them 11th in the Eastern Conference.

With little time to put his stamp on the team, Munthali believes being able to welcome back injured players will help to get them back on track.

"I think as you see players come back into the team [from injury], you see that we're starting to be a little more recognizable as a team that went on a 10-game undefeated streak last season," Munthali said.

"What I would hope is you get a team that represents what the club is: hard-working, forward-thinking and positive, and I hope that's a team we can put onto the field that will compete from start to finish.

"I think those are the cornerstones of who we are as a club."

Montreal are on a four-game losing streak that started with a 4-1 defeat to Nashville, and head coach Laurent Courtois accepts they need to do more to get back to winning ways.

"Doing my 'job' is not enough. We have to be ready to offer a little 'extra' and help each other out. For the moment, in fits and starts, I have the impression that we are just doing our job.

"Now, we are doing our mea culpa, we are coming back to things that we thought we had figured out."

PLAYERS TO WATCH

Montreal Sunusi Ibrahim

In the absence of top-scorer Matias Coccaro, Ibrahim netted Montreals lone goal in their defeat to Toronto last week. Montreal have scored in all four games during their current losing run, with the Nigerian extending that run.

Nashville Hany Mukhtar

Mukhtar attempted five shots, including scoring Nashvilles lone goal from the penalty spot, against Atlanta United on Saturday, taking him to 404 career shot attempts in regular-season MLS play. No other player has attempted 300 shots since Mukhtar joined the league in 2020.

MATCH PREDICTION: DRAW

Montreals lone win in eight all-time meetings with Nashville SC came in their last home match against them, a 1-0 win in June 2023. Nashville has won five of the other seven meetings (D2), including a 4-1 victory on May 4.

However, Nashville have won only one of their last 15 MLS away matches (D5 L9 incl. playoffs) dating back to early June 2023. Nashville scored three goals in the lone win in that time (3-0 at Kansas City) but have totaled just five goals in the other 14 matches.

Meanwhile, Montreal have lost four straight matches within a single regular season for the first time since September 2020. They havent lost five in a row in a single regular season since a five-match losing run to end the 2017 campaign.

OPTA WIN PROBABILITY

Montreal 39%

Draw 27.8%

Nashville 33.2%

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The 8 Best-Tasting Greens Powders of 2024 – EatingWell

Posted: May 23, 2024 at 7:57 am

We dont need to tell you that vegetables are an essential source of vitamins, minerals and antioxidants that support good health. The Dietary Guidelines for Americans recommends adults consume a minimum of 2.5 cups of vegetables per day. Yet so many of us struggle to eat enough of them, or we fall into the habit of reaching for the same veggies day after day.

Greens powders contain a variety of green foods, including common vegetables and grasses and less common plants like seaweed and algae. Theyre added to a liquid, like water or a smoothie, to create a nutrient-rich drink. Its kind of like juicing, but without the mess. You can even add greens powders to sauces, salad dressings, baked goods and frozen desserts for extra nutrients.

You still need to make space on your plate for actual vegetables, but a good greens powder can act like an insurance policy against normal fluctuations in your veggie intake. In addition to greens (obviously), many of these powders contain fruits, herbs, mushrooms and adaptogens to deliver additional antioxidants and functional health benefits. Others tout themselves as detoxifying and digestive aids, and many contain added prebiotics and probiotics to support your gut microbiome.

There can be a lot of health claims and ingredients to comb through, so how do you find the best greens powder? Weve tested 41 greens powders to find ones you will actually want to drink, but only those that have been third-party tested for safety made our final cut. Here are our picks for the best greens powders to add to your wellness routine.

AG1

What we like: It has a balanced taste that works well in water, juice or smoothies.

What to know: It doesn't come cheap at over $3 per serving.

Athletic Greens is becoming the most popular brand of greens powders, thanks to a strong social media presence and prominent advertisements. The attention is well-deserved since AG1 is uniquely formulated with 75 ingredients, including vitamins, minerals and whole foods. It can almost be compared to a liquid multivitamin since it provides well over the daily value for most of the B vitamins, vitamin C and vitamin E. Its also rich in vitamin A and several minerals but lacks vitamin D.

AG1 contains some uncommon greens such as spirulina, chlorella and barley leaf, as well as a long list of superfoods, herbs, adaptogens, functional mushrooms, plant extracts, digestive enzymes and probiotics to support general wellness. We always recommend you check with a healthcare provider before starting a new supplement, and especially so with AG1, since the ingredient list is quite lengthy.

AG1 is undeniably one of the most expensive greens powders, but it continues to impress us. To date, EatingWell editors have taste-tested AG1 on two occasions and both times, its been voted the standout in the competition. In our tests, it mixed easily with water and produced an almost creamy texture. There was still a hint of graininess, but we excused it because the taste was so craveable. AG1s flavor reminds us of a tropical fruit smoothie; its slightly sweet with hints of pineapple and vanilla, not overpowering, and theres barely any aftertaste.

Third-Party Tested: Yes | Certifications: Vegan, gluten-free, non-GMO, dairy-free | Flavors: Original

Amazon

What we like: Combines 12 grams of plant-based protein and greens powders in one.

What to know: The added protein means you may need a more robust mixer than water to mask this powders texture.

If your nutrition goals include increasing both greens and protein intake, dont sleep on Sakaras Organic Protein + Greens Super Powder. As the name suggests, this product is part protein powder and part powdered greens. The greens include nutrient-dense options we like to see, including spirulina, wheatgrass, barley grass and chlorella. The protein comes from a blend of plant-based sources, including pea, hemp and pumpkin.

We loved both the smell and taste of this one. It contains coconut milk powder, vanilla, coconut sugar and stevia, which translates to a creamy texture and pleasantly sweet coconut-vanilla flavor. Because this contains protein powder, you may prefer it mixed in something creamier than water, like almond milk or a smoothie.

Most plant-based protein powders deliver 18 to 25 grams of protein per serving, so this isnt a one-for-one swap for those. However, with 12 grams of protein per serving, itll be more filling than most greens powders and can help you bump up your protein intake. The individual packets are also an excellent option for anyone who takes supplements on the go or travels frequently.

Third-Party Tested: Yes | Certifications: Organic, vegan, gluten-free | Flavors: Vanilla

Amazon

What we like: It contains 3 grams of fiber per serving, which is more than most powders we tested.

What to know: This product doesnt blend as smoothly as others, so mix well!

Amazing Grass makes several greens powders, each formulated slightly differently to support immunity, digestion or detoxification. We tried two: The Original Superfood Greens and the Alkalize & Detox Greens (view at Amazon). The alkalizing blend contains a few more greens varieties, but we preferred the taste and texture of the Original Superfood Greens.

Our testers likened the flavor to a smooth-tasting cup of matcha. It was enjoyable on its own but would also be delicious in milk, juice or smoothies. Whatever liquid you choose, we recommend mixing well since this powder can leave some sediment behind.

If matcha isnt your cup of tea, the Superfood Greens Blend is also available in berry and chocolate flavors. All three flavors are free from added sugar and sweeteners, so theyre a good choice if you prefer a mild, less sweet taste. Many greens powders contain stevia or monk fruit, which can be overpowering for some.

Leafy greens are a good source of vitamin K, which is important for heart health and strong bones. Not all greens powders are a good source of vitamin K, but this one delivers 58 percent of the daily recommended value per serving. In addition to seven types of greens, it contains antioxidants from green tea leaf extract, aai and maca, and extra fiber from flax seed and pectin.

Third-Party Tested: Yes | Certifications: Organic, non-GMO, vegan, kosher, gluten-free | Flavors: Original, Berry, Chocolate

Amazon

What we like: It comes in three flavors to satisfy various tastes.

What to know: The exact vitamin and mineral content isnt listed on the Supplement Facts.

The process of drying and grinding greens into powders can alter their nutrient content since some vitamins, minerals and antioxidants are sensitive to heat and processing. Ancient Nutrition does things a little differently and uses grass juices instead of powdered whole grasses in its SuperGreens product. Ancient Nutrition claims its production methods preserve nutrients, but unfortunately, the company doesnt provide the vitamin and mineral content on the label, so you cant know how many micronutrients these greens add to your diet.

Still, if you want a greens powder that includes a variety of plant ingredients, this is a good option. Its made with more than 25 organic superfood ingredients, including seven types of greens. But perhaps most importantly, it is something we actually want to drink.

Ancient Nutritions SuperGreens powder comes in original, mint, watermelon, mango and berry flavors. Like AG1, weve tested Ancient Nutritions greens twice, and the taste of the mint version has won us over both times. It tastes like a green veggie juice, but the mint helps keep it from being too vegetal. The mint is pleasant on its own but may not be the best choice if youre going to add it to fruit smoothies. We also tried the watermelon flavor, which tasted much sweeter than the mint and reminded us more of cherries than melon. The good news is if youre not a fan of whatever flavor you try, Ancient Nutrition offers a 30-day money-back guarantee.

Third-Party Tested: Yes | Certifications: Organic, non-GMO, vegan, gluten-free | Flavors: Greens, Mint, Watermelon, Berry, Mango

Amazon

What we like: It packs a whopping 21 different ingredients, including leafy greens, veggies and sea plants.

What to know: It has a thicker consistency thats better suited for smoothies than plain water.

One of the main reasons for using a greens powder is to get nutrition from less common but super nutritious greens. Oras greens fit the bill with 21 different ingredients, including grasses, veggies, sea plants, and herbs, including cilantro and parsley.

If you think theres no way that many green ingredients can taste good, youll be pleasantly surprised. Ora adds lemon and orange flavors plus lemon juice powder for a citrusy twist. We didnt find the citrus flavor to be overpowering, and it left no unpleasant aftertaste. If you want more flavor, you could add a squeeze of lemon.

Another thing we like about this greens powder is that it doesnt contain as many extra ingredients as other brands. Its mostly greens, with the exception of three ingredients: oligosaccharides, ashwagandha and triphala. Oligosaccharides are a type of prebiotic fiber that helps support gut microbes, and ashwagandha and triphala are adaptogens believed to support general well-being.

Third-Party Tested: Yes | Certifications: Organic, vegan, kosher | Flavors: Orange

Amazon

What we like: It has 14 grams of protein per serving for extra nutrition and staying power.

What to know: One serving is two scoops, so a 10-ounce container doesnt last long.

Vital Proteins is a leading brand in the collagen industry, and its original collagen peptides took the top spot in our round-up of the best collagen powders. Collagen could help with skin hydration and elasticity and may boost hair growth, so it makes sense that it appears in many beauty supplements. Of course, inner and outer glow doesnt come from collagen alone, so Vital Proteins added greens powders to this product for extra vitamins, minerals and antioxidants.

Collagen Beauty Greens contains 15 grams of collagen peptides, which equates to 14 g of protein per serving. It also contains hyaluronic acid, which can support more youthful skin. This is a solid choice if youre looking for a nutritious mid-morning or mid-afternoon drink. The greens supply vitamins and minerals, and the protein can help keep you full between meals.

If youre already using a collagen supplement, you probably dont need more collagen in your greens. In that case, Vital Proteins also makes Daily Greens (view at Amazon), which contain powdered greens with some prebiotics and probiotics for digestive support. We tested Daily Greens, too, and its taste and mixability were as good as Collagen Beauty Greens, though we preferred the added benefits of this version.

Third-Party Tested: Yes | Certifications: Dairy-free, gluten-free, Whole30-approved | Flavors: Vanilla Coconut

Bulletproof

What we like: It adds subtly sweet notes of pineapple to fruit smoothies.

What to know: It doesnt contain the green grasses found in most powdered greens.

Bulletproof Greens comes from the same company that started the trend of adding butter and medium-chain triglycerides (MCTs) to coffee. It contains vegetables, fruit, superfoods, mushrooms, digestive enzymes, probiotics and nootropics, which are substances that can enhance cognitive function and help you feel more alert and focused.

Noticeably absent here are the green grasses found in most greens powders. Instead, the greens primarily come from spinach, kale, kelp, spirulina and chlorella. You wont be getting the phytochemicals unique to wheatgrass and other grasses. Still, these greens supply 100 percent of the daily value for B vitamins thiamin, riboflavin, niacin, pantothenic acid and B12, which support your central nervous system and gut health, among other benefits. Bulletproof Greens are also a good source of vitamin K2.

In our experience, these greens are gritty when mixed in water, but thats not necessarily a reason to write them off. If youre a smoothie drinker, adding a scoop of greens to your blends can be a great way to give your morning drink a nutritional boost. We found Bulletproofs sweet pineapple flavoring is delicious in fruit-forward smoothies.

Third-Party Tested: Yes | Certifications: Vegan, non-GMO | Flavors: Pineapple

EatingWell / Alexander Huang

Swolverine

What we like: It combines greens with reds powders (derived from foods such as beets and pomegranates) for extra antioxidants.

What to know: Some of us found the strong citrus taste off-putting; wed suggest diluting it with more water than the instructions recommend.

Were big fans of supplements that are committed to labeling transparency. If you want to know exactly how much of each ingredient is in your greens, Swolverine Greens+Reds should be at the top of your list. It contains only three types of greens: spirulina, wheatgrass and chlorella. This powders antioxidant variety comes from added adaptogens and reds powders, which are made from beets, bilberry, blueberry, pomegranate, goji and aai. Despite this long list, the %DV of each ingredient is clearly listed on the label, which is essential for folks who may need to be aware of how certain ingredients may react to medications, for example.

If youre not a fan of citrus, or the aftertaste of stevia or monk fruit, this isnt the greens powder for you. To us, the taste was comparable to an orange cream ice pop with hints of green tea. When we first tried it, we mixed it with eight ounces of water according to the package directions and found the orange flavor and sweetness level were too strong. The texture was also on the thicker side. In the next round, we diluted it with more water, and the taste and texture were much more palatable.

Third-Party Tested: Yes | Certifications: Gluten-free, non-GMO, vegan | Flavors: Orange

EatingWell / Alexander Huang

If youre looking for an easy-drinking greens powder loaded with nutrients, AG1 by Athletic Greens (view at Amazon) remains our favorite. If youre also trying to increase protein intake, we like Sakara Organic Protein + Greens Super Powder (view at Amazon) and Vital Proteins Collagen Beauty Greens (view at Amazon).

With so many greens powders available today, how do you weed out the best from the rest? The top things to consider are third-party testing, ingredients, price and value. Keep these things in mind as you shop to help you find the best greens powder for your needs:

Greens powders fall under the dietary supplement umbrella and are not regulated by the Food and Drug Administration. If your powdered greens are labeled GMP Certified, know that this designation doesnt mean much. GMP refers to good manufacturing practices, which are safety guidelines for production facilities set by the FDA. All food, pharmaceutical, supplement and cosmetic manufacturers have to follow GMP by law, but it doesnt speak to the quality of ingredients or formulations for supplements.

To find a high-quality greens powder, look for one thats been third-party tested (like the greens powders on our list). Independent testing verifies that a product contains the ingredients listed on the label and doesnt contain potentially unsafe levels of contaminants, such as heavy metals. Trusted third-party certifications include NSF and Informed Choiceyou can search for verified products on their websites or look for a seal on the products label.

The most important ingredients in greens powders are, well, powdered greens. We recommend looking for a greens powder that contains a blend of vegetable and/or fruit powders for more vitamin and mineral variety. The powders should come from whole-food ingredients, such as kale, wheatgrass or spirulina.

You can also check the ingredients for proprietary blends. Proprietary blends are simply a group of ingredients. Most supplements that use them list the amount of the blend found in each serving but not the exact amount of each ingredient in that blend. Its not a big deal if you see this on a greens powder, as long as all the ingredients in the blend are from quality sources. However, if you want to know exactly what youre taking, look for brands that use 100 percent labeling transparency for each ingredient.

Some greens powders contain additional ingredients to support digestion and general health. You might find prebiotics, probiotics or digestive enzymes included in greens powders to support digestive health. Adaptogens and functional mushrooms, such as ashwagandha and cordyceps, may be added to support energy, mood and more.

However, certain adaptogens and mushrooms can interact with prescription medications, so its crucial that you check with your doctor before experimenting with a product that contains these ingredients. Please exercise caution and get a doctors approval if youre taking medicine to regulate blood pressure or for an autoimmune disorder, thyroid condition or diabetes. You should also steer clear from these supplements if youre a surgery candidate, pregnant or breastfeeding.

Greens powders range in price from less than $1 per serving to more than $3 per serving. Typically, the greens powders that include the additional ingredients mentioned above cost more than those that are just powdered veggies. So, should you spring for a pricier greens powder? It depends on why you want to use a greens powder and what other supplements and/or medications you may be taking.

Most people are interested in using powdered greens to round out their fruit and veggie intake, so some ingredients may be redundant if you use other supplements. For example, you dont need greens plus probiotics if you already use a digestive health supplement or regularly consume fermented foods, like yogurt and kefir. On the other hand, if a greens powder lists several claims and ingredients that seem to apply to your specific needs and goals, it may be a beneficial addition to your diet.

In our search for the best powdered greens supplements, we rolled up our sleeves and sipped on a total of 41 greens powders. Our testers included a mix of greens powder newbies and some experienced greens users. They all used the same methodology and rating system to assess smell, mixability, texture and taste.

After mixing, sniffing and sipping, EatingWell editors selected the greens powders with the highest ratings and categorized them based on taste, formulation and nutritional benefit to help you make the best choice.

Only eight of the 41 greens powders made our final list, but we want to acknowledge a few of the other options we tried from reputable brands.

Laird Superfood Prebiotic Daily Greens ($51 at Amazon): This greens powder has a strong, sweet citrus flavor thanks to the addition of monk fruit extract and powdered lemon and orange oils. Its a good choice for first-timers or anyone who prefers their greens not to taste so, well, green. Unless citrus pairs well with your smoothies, it may not be a great choice for adding to anything but water.

Suja Organic Greens Powder ($60 at Amazon): If you're a fan of Sujas cold-pressed juices, youll appreciate that their greens powder is made with whole-food ingredients and is certified USDA Organic. It dissolves completely in water and is drinkable but smells and tastes decidedly earthy. This wouldn't be our top suggestion if youre just getting into greens. On the other hand, if you dont want your greens powder flavored or sweetened, or youre going to hide it in a smoothie, this may be the perfect fit.

Thorne Daily Greens Plus ($68 at Amazon): Thorne gets a lot right about dietary supplements, but their greens powder is an exception. Of all the greens we tried, this one had the lowest rating for taste and texture. It has a strong earthy smell and bitter flavor that was off-putting in water and still noticeable when blended in a fruit smoothie. It produced a very grainy texture with lots of leftover sediment, even after stirring for a full minute.

EatingWell / Alexander Huang

Powdered greens can be good for you, especially if they're made from whole-food ingredients, such as vegetables, fruits and seaweed. Preliminary research suggests they may help with inflammation and blood pressure and potentially boost your energy. Most greens powders are low in calories, and the best formulas contain vitamins and minerals. Because dried greens arent the most delicious, most powders contain sweeteners to improve the taste. Look for a greens powder thats low in added sugar and/or flavored with a natural sweetener, like stevia.

Powdered greens dont deliver the same nutrition or health benefits as fresh greens and arent a replacement for eating actual vegetables. Leafy greens and other vegetables are excellent sources of gut-friendly fiber, plus vitamins, minerals and antioxidants that support well-being. Most greens powders contain less fiber than fresh greens, and some micronutrients are heat-sensitive, so theyre minimized or destroyed during the processing of powdered greens.

Most greens powders manufacturers recommend taking one serving per day. If this is your first time trying a greens powder, you should stick to that recommendation for a few weeks or a month to see if you notice a difference in how you feel. If you dont, you may want to try a different brand or revise your goal to include more fruit and veggies on your plate.

Healthy eaters who meet the USDAs recommendation of five servings of fruit and vegetables per day aren't likely to benefit from taking a greens powder.

If youre already taking a multivitamin, a greens powder could be overkill. Double-check the vitamin and mineral dosages on all supplements to ensure you arent getting more than you need.

Pregnant and breastfeeding parents and anyone taking prescription medications should consult with a healthcare provider before taking a greens powder.

Sharon Lehman, RD, is a registered dietitian and contributing writer for EatingWell. She completed her dietetics undergraduate degree at the University of Delaware and is certified as an integrative nutrition coach through the Institute for Integrative Nutrition. She has over six years of experience as a nutrition writer, and her work has also appeared in Simply Recipes and The Spruce Eats.

This article was edited by Katie Tuttle, a commerce editor and contributor to publications such as Food & Wine and The Spruce Eats. It was reviewed by Brierley Horton, M.S., RD, senior commerce editor, with 15 years of experience reporting, writing and editing nutrition and health content.

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The 8 Best-Tasting Greens Powders of 2024 - EatingWell

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Fritz Lang First Depicted Artificial Intelligence on Film in Metropolis (1927), and It Frightened People Even Then – Open Culture

Posted: at 7:56 am

Artificial intelligence seems to have become, as Michael Lewis labeled a previous chapter in the recent history of technology, the new new thing. But human anxieties about it are, if not an old old thing, then at least part of a tradition longer than we may expect. For vivid evidence, look no further than Fritz LangsMetropolis, which brought the very first cinematic depiction of artificial intelligence to theaters in 1927. It imagines a future cleaved in two, where the affluent from lofty skyscrapers rule over a subterranean caste of laborers, writes Synapse Analytics Omar Abo Mosallam. The class tension is so palpable that the invention of a Maschinenmensch (a robot capable of work) upends the social order.

The sheer tirelessness of the Maschinenmensch sows havoc in the city; later, after it takes on the form of a young woman called Maria a transformation you can watch in the clip above it incites workers to rise up and destroy the machines that keep the city functioning. Here, there is a suggestion to associate this new invention with an unraveling of the social order. This robot, whichGuardianfilm critic Peter Bradshaw describes as a brilliant eroticization and fetishization of modern technology, has long beenMetropolis signature figure, more iconic than HAL, Data, and WALLE put together.

Still, those characters all rate mentions of their own in the articles reviewing the history of AI in the movies recently published by the BFI, RT, Pictory, and other outlets besides. The Day the Earth Stood Still, Alien, Blade Runner (and even more so its sequel Blade Runner 2049), Ghost in the Shell, The Matrix, and Ex Machina. Not all of these pictures present their artificially intelligent characters primarily as existential threats to the existing order; the BFIs Georgina Guthrie highlights video essayist-turned-auteur Kogonadas After Yang as an example that treats the role of AI could assume in society as a much more complex indeed, much more human matter.

FromMetropolis toAfter Yang, as RTs Alan Smeaton points out, AI is usually portrayed in movies in a robotic or humanoid-like fashion, presumably because we can easily relate to humanoid and robotic forms. But as the public has come to understand over the past few years, we can perceive a technology as potentially or actually intelligent even it doesnt resemble a human being. Perhaps the age of the fearsome mechanical Art Deco gynoid will never come to pass, but we now feel more keenly than ever both the seductiveness and the threat of Metropolis Maschinenmensch or, as it was named in the original on which the film was based, Futura.

Related content:

Metropolis: Watch Fritz Langs 1927 Masterpiece

Artificial Intelligence, Art & the Future of Creativity: Watch the Final Chapter of the Everything is a Remix Series

Hunter S. Thompson Chillingly Predicts the Future, Telling Studs Terkel About the Coming Revenge of the Economically & Technologically Obsolete (1967)

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Based in Seoul,ColinMarshallwrites and broadcasts on cities, language, and culture. His projects include the Substack newsletterBooks on Cities,the bookThe Stateless City: a Walk through 21st-Century Los Angelesand the video seriesThe City in Cinema. Follow him on Twitter at@colinmarshallor onFacebook.

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Dehumanizing the Wars: Introduction of Artificial Intelligence in the Warfare – Modern Diplomacy

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The dynamics of wars are changing rapidly with the development of new technologies and emergence of Artificial Intelligence. Artificial Intelligence is the key driver in revolutionizing the warfare as it contributed significantly to the introduction of efficient, proficient, and command-oriented devices and programs that have the potential to assist Human controlled processes. The dynamic nature of warfare and the quest for innovation and advancement has led to the introduction of the artificial intelligence in the wars where human aspect of war is being replaced by the artificial intelligence-based developments. Traditionally, wars required a large human force to be fought and the challenging aspect about these wars imposed serious damages to both sides. Even the stronger side or the powerful side had to suffer the damages. There were massive causalities on both sides. The Impact of Industrial Revolution can also be traced the same way as the modern equipment required human power to be an impediment for its working and this accounted for even more damaging aspects in a reciprocal manner.

These patterns began to transform in the twentieth century with the modern data thefts commonly known as cyber-crimes that are becoming more and more important where the data and privacy of a state is breached by the use of different methods and increasing acceptance of Artificial Intelligence based devices such as unmanned combat aerial vehicles (UCAVs) or what we commonly refer to as drones. This led to the introduction of drone warfare as an essential component of modern-day wars. The drones are mainly used under the umbrella of dropping munition over the enemy forces or they can be used in their suicide versions. The suicide versions drones reach the target and then they get explode to fulfill the objective under which they were sent. A significant example in this case is of Russia-Ukraine War in which the drone warfare is becoming extremely important where Russia reported its first use of Shahed-136 drone in September 2022 which was aimed at targeting the military targets in the Kharkiv Region in east of country. In addition to this, Russia is also using Orlan-10 drones to counter the Ukraine who is using Bayraktar Tb-2 drones which are modern drones with increased capacity. The NATO alliances are providing Ukraine with these TB-2 missile and in addition to this, they are also providing Ukraine with SYPAQ and kamikaze drones. The drone warfare is quite effective in this warfare as it had replaced Humans combating the wars with the multiplicity of damages. Not only this, but another use of this drone warfare was also seen in Armenia-Azerbaijan war.

We cannot simply restrict the artificial intelligence to the use of drone warfare. This is because many other attempts are being made to change the dynamics of warfare. A significant advancement in this form is the introduction of robots in the wars. Recently, the military robots began shaping the RUSSIA-UKRAINE war. The Uncrewed Ground Vehicles (UGVs) which are military robots operated by remote control are being used by Russia against Ukraine. An important example in this regard is the use of AGS-17 grenade launchers against Ukraine in the Avdiivka. In order to counter the Russian robots, Ukraine has installed the ChaBla robotic turret which is a remote-based machine gun system, to its front line. Ukrainian officials-as reported in the defense news- termed the use of ground robots as game changer in the war

The transition in warfare has been observed in the form of increasing reliance and use of artificial intelligence. In the current times, the role of artificial intelligence is becoming more and more relevant thus replacing the human role in wars as the direct conflicts involving humans fighting against each other, are being replaced by the type of conflicts where use of AI based devices is increasing to combat the humans on the other side. This can be called the dehumanization of wars, as wars are being fought through the remote controlled or software-oriented devices unlike, with human powers which had dominated the wars in the form of large military troops. So, from the use of Dynamic Analysis and Replanning Tool (DART) to schedule the transportation of supplies and personnel and to solve other logistical problems in 1991 to the use of drones and robots in the on-going Russia-Ukraine war and the assumptions of development of advanced weapons, equipments, navigation systems, and surveillance mechanisms operated by AI etc. will be a step towards changing the character of war by minimizing the Human role in wars.

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