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Monthly Archives: January 2024
Pusan National University’s Breakthrough in Muscle Regeneration: Nanotech Scaffolding Supports Tissue Growth – AZoNano
Posted: January 20, 2024 at 6:47 am
MXene nanoparticle scaffolds have been shown to stimulate muscle growth, making them a promising option to treat muscle loss and damage. Now, researchers from Pusan National University explain the molecular mechanisms behind their positive influence on muscle regeneration. This discovery can advance MXene scaffolds, potentially improving muscle reconstruction surgeries and establishing them as a standard medical practice for muscle recovery.
Tissue engineering, which involves the use of grafts or scaffolds to aid cell regeneration, is emerging as a key medical practice for treating volumetric muscle loss (VML), a condition where a significant amount of muscle tissue is lost beyond the body's natural regenerative capacity. To improve surgical outcomes, traditional muscle grafts are giving way to artificial scaffold materials, with MXene nanoparticles (NPs) standing out as a promising option.
MXene NPs are 2D materials primarily composed of transition-metal carbides and nitride. They are highly electrically conductive, can accommodate a wide range of functional groups, and have stacked structures that promote cell interactions and muscle growth. While there have been practical demonstrations in the laboratory showcasing their ability to promote the reconstruction of skeletal muscles, the specific mechanism by which they do so remains unclear.
To address this gap, Associate Professor Yun Hak Kim from the Department of Anatomy and Department of Biomedical Informatics alongside Professors Suck Won Hong, and Dong-Wook Han from the Department of Cogno-Mechatronics Engineering at Pusan National University, developed nanofibrous matrices containing MXene NPs as scaffolds. They used DNA sequencing to reveal the genes and biological pathways activated by MXene NPs to aid in muscle regeneration. These findings, published on4 January 2024, in Volume 16 ofNano-Micro Letters,mark a significantly advancement in the use of MXene scaffolds for treating muscle damage.
This discovery posits a prospective avenue for the utilization of these materials to augment the efficacy of muscle tissue regeneration post-injury or damage,explains Professor Kim.
In the initial phase, the team created a nanofibrous PCM matrix containing poly(lactide-co--caprolactone) (P), reinforced with collagen (C), and Ti3C2TxMXene nanoparticles (M). To determine the specific effect of MXene NPs on muscle growth, they prepared three controls: pristine PLCL (P), PLCL with Collagen (PC), and PLCL with MXene (PM). On testing all the scaffolds on mouse models with induced volumetric muscle loss, the researchers observed a significant increase in the overall number of muscle cells in PCM-treated mice compared to the other groups.
To understand how MXene nanoparticles (NPs) impact muscle regeneration and growth at the molecular level, the researchers introduced C2C12myoblasts, which are precursors of muscle cells, onto PC and PCM matrices. The objective was to analyze the differences in gene expression levels between the two matrices. Within the PCM matrix, a heightened production of inducible nitric oxide synthase (iNOS) and serum/glucocorticoid-regulated kinase 1 (SGK1) was identifiedtwo proteins closely associated with calcium signaling and muscle regeneration.
These results suggest that MXenes promote calcium ion (Ca2+) deposition around cells. This heightened levels of intracellular Ca2+triggers the activation of genes that produce iNOS and SGK1 proteins. SGK1 influences the mTOR-AKT pathway, promoting cell proliferation, survival, and myogenesisthe conversion of myoblasts to muscle fibers. Simultaneously, iNOS increases the production of nitric oxide (NO), contributing to myoblast proliferation and muscle fiber fusion. The combined effects lead to the development of mature muscle tissue. The aligned PCM nanofibrous matrices offer biophysical cues for intracellular biochemical signaling, guiding myogenic behaviors. This discovery contributes to our understanding of MXene's potential to regrow muscle and holds promise for refining scaffold designs to enhance this process further.
Within 5 to 10 years, this research may yield groundbreaking treatments for muscle injuries. MXene NP-infused matrices could become a routine in medical practice for athletes, people with muscle-related ailments, and those recuperating from muscle-related traumas or surgeries,Prof. Kim optimistically states.These NPs might enhance muscle regeneration methods, offering improved outcomes for reconstructive surgeries and conditions like muscular dystrophy, where muscle function is compromised,he further adds.
The MXene NP-infused matrices hold potential for customization to meet diverse needs in treating muscle loss injuries. This customization may involve adjusting composition, structure, or properties to match specific patient requirements, like size, shape, or bioactivity enhancement. Tailoring these materials could offer personalized solutions for various muscle loss severities. Additionally, the observed enhanced muscle regeneration could aid in a more efficient recovery, potentially reducing post-treatment rehabilitation needs.
These matrices, with controllable mechanical properties, hold promise for enhancingin vivomuscle regeneration. Further research into MXene promises expanded clinical applications, potentially benefiting human well-being.
Source: https://www.pusan.ac.kr/eng/Main.do
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Pusan National University’s Breakthrough in Muscle Regeneration: Nanotech Scaffolding Supports Tissue Growth – PR Newswire
Posted: at 6:47 am
BUSAN, South Korea, Jan. 19, 2024 /PRNewswire/ -- Tissue engineering, which involves the use of grafts or scaffolds to aid cell regeneration, is emerging as a key medical practice for treating volumetric muscle loss (VML), a condition where a significant amount of muscle tissue is lost beyond the body's natural regenerative capacity. To improve surgical outcomes, traditional muscle grafts are giving way to artificial scaffold materials, with MXene nanoparticles (NPs) standing out as a promising option.
MXene NPs are 2D materials primarily composed of transition-metal carbides and nitride. They are highly electrically conductive, can accommodate a wide range of functional groups, and have stacked structures that promote cell interactions and muscle growth. While there have been practical demonstrations in the laboratory showcasing their ability to promote the reconstruction of skeletal muscles, the specific mechanism by which they do so remains unclear.
To address this gap, Associate Professor Yun Hak Kim from the Department of Anatomy and Department of Biomedical Informatics alongside Professors Suck Won Hong, and Dong-Wook Han from the Department of Cogno-Mechatronics Engineering at Pusan National University, developed nanofibrous matrices containing MXene NPs as scaffolds. They used DNA sequencing to reveal the genes and biological pathways activated by MXene NPs to aid in muscle regeneration. These findings, published on 4 January, 2024, in Volume 16 of Nano-Micro Letters, mark a significantly advancement in the use of MXene scaffolds for treating muscle damage.
"This discovery posits a prospective avenue for the utilization of these materials to augment the efficacy of muscle tissue regeneration post-injury or damage,"explains Professor Kim.
In the initial phase, the team created a nanofibrous PCM matrix containing poly(lactide-co--caprolactone) (P), reinforced with collagen (C), and Ti3C2Tx MXene nanoparticles (M). To determine the specific effect of MXene NPs on muscle growth, they prepared three controls: pristine PLCL (P), PLCL with Collagen (PC), and PLCL with MXene (PM). On testing all the scaffolds on mouse models with induced volumetric muscle loss, the researchers observed a significant increase in the overall number of muscle cells in PCM-treated mice than in other groups.
Further investigations revealed that MXenes promote calcium ion (Ca2+) deposition around cells. This heightened levels of intracellular Ca2+ triggers the activation of genes that produce inducible nitric oxide synthase (iNOS) and serum/glucocorticoid-regulated kinase 1 (SGK1) proteins. SGK1 influences the mTOR-AKT pathway, promoting cell proliferation, survival, and myogenesisthe conversion of myoblasts to muscle fibers. Simultaneously, iNOS increases the production of nitric oxide (NO), contributing to myoblast proliferation and muscle fiber fusion. The combined effects lead to the development of mature muscle tissue.
This discovery contributes to our understanding of MXene's potential to regrow muscle and holds promise for refining scaffold designs to enhance this process further. "Within 5 to 10 years, this research may yield groundbreaking treatments for muscle injuries," Prof. Kim optimistically states.
Reference
Title of original paper: Highly aligned ternarynanofiber matrices loaded with MXene expedite regeneration of volumetric muscle loss
Journal: Nano-Micro Letters
DOI: https://doi.org/10.1007/s40820-023-01293-1
About the institute
Pusan National University, located in Busan, South Korea, was founded in 1946, and is now the no. 1 national university of South Korea in research and educational competency. The multi-campus university also has other smaller campuses in Yangsan, Miryang, and Ami. The university prides itself on the principles of truth, freedom, and service, and has approximately 30,000 students, 1200 professors, and 750 faculty members. The university is composed of 14 colleges (schools) and one independent division, with 103 departments in all. Website: https://www.pusan.ac.kr/eng/Main.do
Media Contact:Jae-Eun Lee 82 51 510 7928 [emailprotected]
SOURCE Pusan National University
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Transhumanism: billionaires want to use tech to enhance our abilities the outcomes could change what it means to … – The Conversation
Posted: January 18, 2024 at 6:10 pm
Many prominent people in the tech industry have talked about the increasing convergence between humans and machines in coming decades. For example, Elon Musk has reportedly said he wants humans to merge with AI to achieve a symbiosis with artificial intelligence.
His company Neuralink aims to facilitate this convergence so that humans wont be left behind as technology advances in the future. While people with disabilities would be near-term recipients of these innovations, some believe technologies like this could be used to enhance abilities in everyone.
These aims are inspired by an idea called transhumanism, the belief that we should use science and technology to radically enhance human capabilities and seek to direct our own evolutionary path. Disease, aging and death are all realities transhumanists wish to end, alongside dramatically increasing our cognitive, emotional and physical capacities.
Transhumanists often advocate for the three supers of superintelligence, superlongevity and superhappiness, the last referring to ways of achieving lasting happiness. There are many different views among the transhumanist community of what our ongoing evolution should look like.
For example, some advocate uploading the mind into digital form and settling the cosmos. Others think we should remain organic beings but rewire or upgrade our biology through genetic engineering and other methods. A future of designer babies, artificial wombs and anti-aging therapies appeal to these thinkers.
This may all sound futuristic and fantastical, but rapid developments in artificial intelligence (AI) and synthetic biology have led some to argue we are on the cusp of creating such possibilities.
Tech billionaires are among the biggest promoters of transhumanist thinking. It is not hard to understand why: they could be the central protagonists in the most important moment in history.
Creating so-called artificial general intelligence (AGI) that is, an AI system that can do all the cognitive tasks a human can do and more is a current focus within Silicon Valley. AGI is seen as vital to enabling us to take on the God-like role of designing our own evolutionary futures.
That is why companies like OpenAI, DeepMind and Anthropic are racing towards the development of AGI, despite some experts warning that it could lead to human extinction.
In the short term, the promises and the perils are probably overstated. After all, these companies have a lot to gain by making us think they are on the verge of engineering a divine power that can create utopia or destroy the world. Meanwhile, AI has played a role in fuelling our polarised political landscape, with disinformation and more complex forms of manipulation made more effective by generative AI.
Indeed, AI systems are already causing many other forms of social and environmental harm. AI companies rarely wish to address these harms though. If they can make governments focus on long-term potential safety issues relating to possible existential risks instead of actual social and environmental injustices, they stand to benefit from the resulting regulatory framework.
But if we lack the capacity and determination to address these real world harms, its hard to believe that we will be able to mitigate larger-scale risks that AI may hypothetically enable. If there really is a threat that AGI could pose an existential risk, for example, everyone would shoulder that cost, but the profits would be very much private.
This issue within AI development can be seen as a microcosm of why the wider transhumanist imagination may appeal to billionaire elites in an age of multiple crises. It speaks to the refusal to engage in grounded ethics, injustices and challenges and offers a grandiose narrative of a resplendent future to distract from the current moment.
Our misuse of the planets resources has set in train a sixth mass extinction of species and a climate crisis. In addition, ongoing wars with increasingly potent weapons remain a part of our technological evolution.
Theres also the pressing question of whose future will be transhuman. We currently live in a very unequal world. Transhumanism, if developed in anything like our existing context, is likely to greatly increase inequality, and may have catastrophic consequences for the majority of humans.
Perhaps transhumanism itself is a symptom of the kind of thinking that has created our parlous social reality. It is a narrative that encourages us to hit the gas, expropriate nature even more, keep growing and not look back at the devastation in the rear-view mirror.
If were really on the verge of creating an enhanced version of humanity, we should start to ask some big questions about what being human should mean, and therefore what an enhancement of humanity should entail.
If the human is an aspiring God, then it lays claim to dominion over nature and the body, making all amenable to its desires. But if the human is an animal embedded in complex relations with other species and nature at large, then enhancement is contingent on the health and sustainability of its relations.
If the human is conceived of as an environmental threat, then enhancement is surely that which redirects its exploitative lifeways. Perhaps becoming more-than-human should constitute a much more responsible humanity.
One that shows compassion to and awareness of other forms of life in this rich and wondrous planet. That would be preferable to colonising and extending ourselves, with great hubris, at the expense of everything, and everyone, else.
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Google CEO Warns Staff of More Job Cuts, Says Company to Unveil AI Goals This Week – Investopedia
Posted: at 6:10 pm
KEY TAKEAWAYS
Google is planning additional job cuts this year, as the firm pivots further into fast-growing areas such as artificial intelligence (AI).
In a memo sent to employees Wednesday, Sundar Pichai, chief executive officer of Google-parent Alphabet (GOOGL), said that tough choices need to be made in order for the company to be able to invest in its priority areas. For some teams that means eliminating roles, which includes removing layers to simplify execution and drive velocity, he added.
The Google CEO's warning follows hundreds of job cuts earlier this month. Last year, the company let go of 12,000 permanent team members,or around 6% of its workforce.
In the memo titled "2024 priorities and the year ahead," Pichai said the headcount reductions in 2024 wont be on the same scale as last year. He also noted that the company will unveil its AI goals for 2024, as well as its objectives and key results, this week.
Google launched Gemini, its latest AI model with text, code, audio, image, and video capabilities, last month. The tech giant claims the model largely outperforms Microsoft-backed (MSFT) OpenAI's GPT-4 and could help bolster the company's position in the AI race.
Shares in Google's parent company Alphabet were up 0.6% at $142.33 at 10:07 a.m. ET.
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It’s not just you, Google Search really has gotten worse – Mashable
Posted: at 6:10 pm
UPDATE: Jan. 18, 2024, 12:49 p.m. EST Updated with comment from Google and additional context.
Has your Google Search experience changed for the worse? You may not be alone.
This revelation comes from a new study by German researchers from Leipzig University, Bauhaus-University Weimar, and the Center for Scalable Data Analytics and Artificial Intelligence. The researchers posed the question "Is Google Getting Worse?", examining 7,392 product review queries on Google, Bing, and DuckDuckGo for a year.
The researchers worked off reports that "a torrent of low-quality content, especially for product search, keeps drowning any kind of useful information in search results." A significant amount of results found in response to product-related queries were "outright SEO product review spam."
The research showed that spam sites are hyper prevalent, showing up at the top of Google's rankings in what is "a constant battle" between the sites and search engine. In other words, they write, "search engines seem to lose the cat-and-mouse game that is SEO spam."
"SEO is a constant battle and we see repeated patterns of review spam entering and leaving the results as search engines and SEO engineers take turns adjusting their parameters," reads the report. Despite Google, Bing, and DuckDuckGo taking down spam, the researchers stated this only results in "a temporary positive effect."
A Google spokesperson told Mashable that the study "doesn't reflect the overall quality and helpfulness of Search." They emphasized that the study only focuses on a narrow set of queries namely product search.
"This particular study looked narrowly at product review content, and it doesnt reflect the overall quality and helpfulness of Search for the billions of queries we see every day. Weve launched specific improvements to address these issues and the study itself points out that Google has improved over the past year and is performing better than other search engines. More broadly, numerous third parties have measured search engine results for other types of queries and found Google to be of significantly higher quality than the rest," said the spokesperson.
The study in question showed that Google results did improve "to some extent" between the start of the researchers' experiment and the end. Still, they found "an overall downwards trend in text quality in all three search engines." With the presence of AI-generated spam, this is only likely to get worse, the research warns.
"We conclude that dynamic adversarial spam in the form of low-quality, mass-produced commercial content deserves more attention," wrote the researchers.
As reported by 404Media, Google being flooded by spam is being noticed by other researchers. Search Engine Journal, for example, declared that Google was overcome "by a massive spam attack" in December 2023 one that lasted for days.
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It's not just you, Google Search really has gotten worse - Mashable
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Google.org Grants $2.8M to WFP USA in Support of Innovation – World Food Program USA
Posted: at 6:09 pm
WASHINGTON, D.C. (January 18, 2024) World Food Program USA has received a $2.8 million grant from Google.org, marking a significant milestone in the fight against global hunger. This grant supports the United Nations World Food Programme (WFP) Innovation Accelerator, a cutting-edge initiative aimed at leveraging innovation and technology to tackle food insecurity worldwide.
We consider the private sector, particularly Google.org, to be best-in-class innovators and visionaries and we rely on their expertise to help us create systemic innovations that will transform our efforts to eradicate global hunger. We are very appreciative of Google.orgs support, said Barron Segar, World Food Program USA President and CEO.
Stuart McLaughlin, director, advocacy and strategic partnerships at Google.org, made the announcement during an official side-event of the 2024 World Economic Forum hosted by the WFP Innovation Accelerator, Galvanizing Impact Innovation for Zero Hunger, which highlighted Google.orgs commitment to empowering communities and advancing innovative solutions to global challenges.
By harnessing the power of innovation and technology, together, we aspire to drive meaningful change and address global food insecurity. This grant exemplifies our commitment to creating a sustainable and hunger-free future for all, said McLaughlin.
The WFP Innovation Accelerator focuses on integrating advanced technologies such as Artificial Intelligence (AI), data analytics, blockchain and new business models to improve humanitarian response and address the root causes of hunger. The grant will fund an acceleration program aimed at developing and scaling 10 ventures created and developed within WFP. These solutions, anchored in technological innovation, aim to improve emergency response, supply chain efficiency, and support for small-scale farmers in many of the worlds most vulnerable communities, including in Yemen, Afghanistan, Somalia, and Haiti. The program includes a comprehensive package of cutting-edge business support, scaling strategies and grant funding.
This partnership amplifies our capacity to leverage cutting-edge technology with WFPs global operational capacity. Google stepping up the support in times of a global food crisis is critical to scale game-changing solutions to create more impact for some of the most vulnerable people across the world. said Bernhard Kowatsch, head of the WFP Innovation Accelerator.
This significant investment by Google.org is part of its ongoing commitment to creating sustainable and impactful solutions in global communities. It also marks a key moment in the collaboration between the technology sector and humanitarian organizations.
About Google.org Google.org, Googles philanthropy, brings the best of Google to help solve some of humanitys biggest challenges combining funding, product donations and technical expertise to support underserved communities and provide opportunity for everyone. We engage nonprofits, social enterprises and civic entities who make a significant impact on the communities they serve, and whose work has the potential to produce scalable, meaningful change.
About World Food Program USA World Food Program USA, a 501(c)(3) organization based in Washington, D.C., proudly supports the mission of the United Nations World Food Programme by mobilizing American policymakers, businesses and individuals to advance the global movement to end hunger. Our leadership and support help to bolster an enduring American legacy of feeding families in need around the world. To learn more, please visit wfpusa.org.
About the United Nations World Food Programme Innovation Accelerator The WFP Innovation Accelerator, started in 2015, is one of the worlds biggest social impact startup accelerators. It offers 16 annual programs to the broader ecosystem on multiple social impact and sustainability issues, such as hunger, climate change, primary healthcare, gender equality, and emergency response. In 2022 alone, the portfolio of 150+ startups and innovations impacted 37 million people globally. Since launch, the WFP Innovation Accelerator has maintained a 2X growth rate every year and raised over $200 million in grants for innovations. For more information, visit https://innovation.wfp.org/.
Media Contacts Toula Athas World Food Program USA tathas@wfpusa.org
Press@Google.com Google inquiries
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As Google Pivots to AI, CEO Warns He Will Fire Even More Staff – Futurism
Posted: at 6:09 pm
How many people are going to get the axe in favor of AI? Be Evil
Google has laid off more than a thousand people since January 10 and according to CEO Sundar Pichai, there will be more firings in the future as the company pushes forward with its AI pivot.
"We have ambitious goals and will be investing in our big priorities this year," Pichai told Google's staff in a company-wide email reviewed byThe Verge. "The reality is that to create the capacity for this investment, we have to make tough choices."
Those layoffs, as prior reporting from Business Insider andAxios indicates, took place across several departments. Hundreds were in the company's advertising and customer sales teams, while others impacted the Google Assistant, Fitbit, and hardware verticals.
In the more recent memo, the CEO said that although the more recent and forthcoming "role eliminations" will not be "at the scale of last years reductions" a reference to the 12,000 jobs Google cut around this time last year the company will continue down the path of "removing layers to simplify execution and drive velocity in some areas."
Google's forthcoming "layer-removal" comes on the heels of the company's tumultuous 2023, which along with the 12,000 cuts at the beginning of the year saw it pivot to AI much like its peers and competitors.
Indeed, as the New York Times reported based on insider interviews late last year, the company's pivot to AI was made hastily as OpenAI's ChatGPT and its alliance with Microsoft threatened to leave more established tech players else in its dust.
Just before Christmas 2022, theNYT's reporting explains, the company's top lawyer summoned executives to deliver a directive: that their teams were to drop whatever they had previously been working on and begin developing a slate of AI products immediately, per Pichai's orders. Just over a month later, those 12,000 employees were axed, and now we appear to be seeing the continued toll of that rapid decision-making process.
AsAxios aptly pointed out in its own analysis of the 2024 Google layoffs, it seems less that people are being replaced by AI itself and more that they are being replaced with smaller teams of people who are good with the technology as the company adjusts course.
It's hard to say how those AI-adept new workers feel about their roles, but it seems likely they're essentially building the tech that will eventually replace them and that can't feel good.
More on Google: Image Database Powering Google's AI Contains Explicit Images of Children
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As Google Pivots to AI, CEO Warns He Will Fire Even More Staff - Futurism
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Introducing ASPIRE for selective prediction in LLMs Google Research Blog – Google Research
Posted: at 6:09 pm
Posted by Jiefeng Chen, Student Researcher, and Jinsung Yoon, Research Scientist, Cloud AI Team
In the fast-evolving landscape of artificial intelligence, large language models (LLMs) have revolutionized the way we interact with machines, pushing the boundaries of natural language understanding and generation to unprecedented heights. Yet, the leap into high-stakes decision-making applications remains a chasm too wide, primarily due to the inherent uncertainty of model predictions. Traditional LLMs generate responses recursively, yet they lack an intrinsic mechanism to assign a confidence score to these responses. Although one can derive a confidence score by summing up the probabilities of individual tokens in the sequence, traditional approaches typically fall short in reliably distinguishing between correct and incorrect answers. But what if LLMs could gauge their own confidence and only make predictions when they're sure?
Selective prediction aims to do this by enabling LLMs to output an answer along with a selection score, which indicates the probability that the answer is correct. With selective prediction, one can better understand the reliability of LLMs deployed in a variety of applications. Prior research, such as semantic uncertainty and self-evaluation, has attempted to enable selective prediction in LLMs. A typical approach is to use heuristic prompts like Is the proposed answer True or False? to trigger self-evaluation in LLMs. However, this approach may not work well on challenging question answering (QA) tasks.
In "Adaptation with Self-Evaluation to Improve Selective Prediction in LLMs", presented at Findings of EMNLP 2023, we introduce ASPIRE a novel framework meticulously designed to enhance the selective prediction capabilities of LLMs. ASPIRE fine-tunes LLMs on QA tasks via parameter-efficient fine-tuning, and trains them to evaluate whether their generated answers are correct. ASPIRE allows LLMs to output an answer along with a confidence score for that answer. Our experimental results demonstrate that ASPIRE significantly outperforms state-of-the-art selective prediction methods on a variety of QA datasets, such as the CoQA benchmark.
Imagine teaching an LLM to not only answer questions but also evaluate those answers akin to a student verifying their answers in the back of the textbook. That's the essence of ASPIRE, which involves three stages: (1) task-specific tuning, (2) answer sampling, and (3) self-evaluation learning.
Task-specific tuning: ASPIRE performs task-specific tuning to train adaptable parameters (p) while freezing the LLM. Given a training dataset for a generative task, it fine-tunes the pre-trained LLM to improve its prediction performance. Towards this end, parameter-efficient tuning techniques (e.g., soft prompt tuning and LoRA) might be employed to adapt the pre-trained LLM on the task, given their effectiveness in obtaining strong generalization with small amounts of target task data. Specifically, the LLM parameters () are frozen and adaptable parameters (p) are added for fine-tuning. Only p are updated to minimize the standard LLM training loss (e.g., cross-entropy). Such fine-tuning can improve selective prediction performance because it not only improves the prediction accuracy, but also enhances the likelihood of correct output sequences.
Answer sampling: After task-specific tuning, ASPIRE uses the LLM with the learned p to generate different answers for each training question and create a dataset for self-evaluation learning. We aim to generate output sequences that have a high likelihood. We use beam search as the decoding algorithm to generate high-likelihood output sequences and the Rouge-L metric to determine if the generated output sequence is correct.
Self-evaluation learning: After sampling high-likelihood outputs for each query, ASPIRE adds adaptable parameters (s) and only fine-tunes s for learning self-evaluation. Since the output sequence generation only depends on and p, freezing and the learned p can avoid changing the prediction behaviors of the LLM when learning self-evaluation. We optimize s such that the adapted LLM can distinguish between correct and incorrect answers on their own.
In the proposed framework, p and s can be trained using any parameter-efficient tuning approach. In this work, we use soft prompt tuning, a simple yet effective mechanism for learning soft prompts to condition frozen language models to perform specific downstream tasks more effectively than traditional discrete text prompts. The driving force behind this approach lies in the recognition that if we can develop prompts that effectively stimulate self-evaluation, it should be possible to discover these prompts through soft prompt tuning in conjunction with targeted training objectives.
After training p and s, we obtain the prediction for the query via beam search decoding. We then define a selection score that combines the likelihood of the generated answer with the learned self-evaluation score (i.e., the likelihood of the prediction being correct for the query) to make selective predictions.
To demonstrate ASPIREs efficacy, we evaluate it across three question-answering datasets CoQA, TriviaQA, and SQuAD using various open pre-trained transformer (OPT) models. By training p with soft prompt tuning, we observed a substantial hike in the LLMs' accuracy. For example, the OPT-2.7B model adapted with ASPIRE demonstrated improved performance over the larger, pre-trained OPT-30B model using the CoQA and SQuAD datasets. These results suggest that with suitable adaptations, smaller LLMs might have the capability to match or potentially surpass the accuracy of larger models in some scenarios.
When delving into the computation of selection scores with fixed model predictions, ASPIRE received a higher AUROC score (the probability that a randomly chosen correct output sequence has a higher selection score than a randomly chosen incorrect output sequence) than baseline methods across all datasets. For example, on the CoQA benchmark, ASPIRE improves the AUROC from 51.3% to 80.3% compared to the baselines.
An intriguing pattern emerged from the TriviaQA dataset evaluations. While the pre-trained OPT-30B model demonstrated higher baseline accuracy, its performance in selective prediction did not improve significantly when traditional self-evaluation methods Self-eval and P(True) were applied. In contrast, the smaller OPT-2.7B model, when enhanced with ASPIRE, outperformed in this aspect. This discrepancy underscores a vital insight: larger LLMs utilizing conventional self-evaluation techniques may not be as effective in selective prediction as smaller, ASPIRE-enhanced models.
Our experimental journey with ASPIRE underscores a pivotal shift in the landscape of LLMs: The capacity of a language model is not the be-all and end-all of its performance. Instead, the effectiveness of models can be drastically improved through strategic adaptations, allowing for more precise, confident predictions even in smaller models. As a result, ASPIRE stands as a testament to the potential of LLMs that can judiciously ascertain their own certainty and decisively outperform larger counterparts in selective prediction tasks.
In conclusion, ASPIRE is not just another framework; it's a vision of a future where LLMs can be trusted partners in decision-making. By honing the selective prediction performance, we're inching closer to realizing the full potential of AI in critical applications.
Our research has opened new doors, and we invite the community to build upon this foundation. We're excited to see how ASPIRE will inspire the next generation of LLMs and beyond. To learn more about our findings, we encourage you to read our paper and join us in this thrilling journey towards creating a more reliable and self-aware AI.
We gratefully acknowledge the contributions of Sayna Ebrahimi, Sercan O Arik, Tomas Pfister, and Somesh Jha.
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New Google Chat redesign widely rolling out on Android [U] – 9to5Google
Posted: at 6:09 pm
With the new icon widely rolled out, Google Chats homescreen redesign is now making its way to Android.
Update 1/17/24: Were now seeing much wider availability of the redesigned Google Chat. The rollout has ramped up in recent days and we now have it on all our devices after force closing the standalone Chat app and Gmail. (In the latter app, the homescreen widget has also been updated to just feature two tabs in the pseudo-bottom bar.)
You still have to manually enable the Chat tab from Gmail Settings > your email address > General. Unlike Meet, Google never rolled out the integrated Google Chat experience to all users.
Original 12/19/23: In the standalone Google Chat app, the two-tab bottom bar and New FAB as seen below have been replaced.
Instead of tabs for Chat and Spaces, you now have Home, Direct messages, Spaces, and Mentions in a pill-shaped container.
A circular indicator notes what tab youre currently viewing. (A nice touch would have been having the circle glide/animate through as you switch between feeds.)There are no labels underneath each icon, but you can find that information at the top of your screen below the search bar. Thankfully, the Google Chat icons are pretty straightforward.
Meanwhile, theres a rounded square FAB to the right of the pill that is ever so slightly smaller. These two elements are centered.
In Gmail, this floating pill appears above the existing bottom bar, which has been consolidated to three tabs. While this navigation approach is fine in the dedicated app, the integrated Gmail experience looks rather busy.
This redesign first rolled out to Google Chat and Gmail for iOS, as well as the web. On Android, its slowly appearing on an account-by-account basis with a server-side update. Were seeing it on a personal Google Account today.
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Google Breaks Another Promise About Tracking Your Location History – Gizmodo
Posted: at 6:09 pm
Google pledged to stop tracking user visits to abortion clinics shortly after Roe v. Wade was overturned in June 2022, which killed off the United States largest federal abortion protection. The measure aimed to protect abortion seekers from prosecutors, especially in the 14 states where abortion is now banned. Roughly 18 months later, Google has not followed through on its promise, according to a new study from Accountable Tech, and the company still tracks visits to abortion clinics.
No Google AI Search, I Dont Need to Learn About the Benefits of Slavery
Googles location data is one of law enforcements favorite tools in the United States. The U.S. government requested the companys data over 63,000 times in the first half of 2023, reaching an all-time high, and Google handed over data 85% of the time. Thats why the companys tracking of visits to abortion clinics is a big deal, and why its promise to stop was so celebrated. However, a new study published on Thursday ran tests in seven states across the country and found that Google is still collecting Location History data for visits to abortion clinics, despite their promise. Accountable Tech says this report makes it clear that Google cannot be trusted to follow-through on its privacy promises.
The study ran experiments in Pennsylvania, Texas, Nevada, Florida, New York, Georgia, and North Carolina. In 50% of its tests, Accountable Tech found that routes to and from Planned Parenthood locations were saved in Googles Location History. The actual name, Planned Parenthood, was scrubbed from Googles data, which mirrors Accountable Techs study from a year ago, but the data still clearly points to abortion clinic visits.
Google announced last December it would no longer hold onto peoples location data which would mean it cant turn that information over to the police. Accountable Tech says this was a positive development, but that Google cant be trusted at face value on promises like this. The company received 5,764 geofence warrants in states where abortion is banned between 2018 and 2020, according to Politico.
Google did not immediately respond to Gizmodos request for comment.
Google notes that its Location History feature is default turned off, and you can turn it on if you choose. Its unclear how many users Google tracks location data on, but its estimated the company is one of the worlds largest data trackers, with over a billion users of Google Maps globally.
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Google Breaks Another Promise About Tracking Your Location History - Gizmodo
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