Monthly Archives: November 2023

Omega Therapeutics Showcases Bidirectional and Multiplexed … – BioSpace

Posted: November 15, 2023 at 3:02 am

CAMBRIDGE, Mass., Nov. 13, 2023 (GLOBE NEWSWIRE) -- Omega Therapeutics, Inc. (Nasdaq: OMGA) (Omega), a clinical-stage biotechnology company pioneering the development of a new class of programmable epigenomic mRNA medicines, today announced the presentation of new preclinical data from two different programs that demonstrated sustained upregulation of gene expression and coordinated pre-transcriptional downregulation of multiple genes in models of liver fibrosis and inflammation, respectively, at the American Association for the Study of Liver Diseases (AASLD) The Liver Meeting 2023, taking place in Boston, Massachusetts, November 10 14.

Genetic medicines have made tremendous progress towards precise downregulation of gene expression. However, to extend their reach, we need to bidirectionally control the expression of multiple genes simultaneously, said Thomas McCauley, Ph.D., Chief Scientific Officer of Omega Therapeutics. We believe that these new data demonstrate the power of our programmable epigenomic mRNA development candidates to control gene expression with unmatched flexibility. To our knowledge, these are the first results to show how site-specific epigenomic modulation can durably upregulate the expression of a master liver regeneration gene. Additionally, a second poster highlights our ability to multiplex gene regulation with a single construct to control a cluster of inflammatory chemokines. These exciting results highlight the progress we have made and possible applications of our approach in multiple liver diseases.

Poster 3444-A: Induction of Hepatocyte Nuclear Factor 4 alpha (HNF4) using novel epigenomic controllers

Key Findings

Poster 2621-A: Targeting CXCL9/CXCL10/CXCL11 using novel epigenomic controllers for the treatment of inflammatory liver disease

Key Findings:

These posters are available on the Omega website at https://omegatherapeutics.com/science/publications.

About Omega Therapeutics Omega Therapeutics is a clinical-stage biotechnology company pioneering the development of a new class of programmable epigenomic mRNA medicines to treat or cure a broad range of diseases. By pre-transcriptionally modulating gene expression, Omegas approach enables controlled epigenomic modulation of nearly all human genes, including historically undruggable and difficult-to-treat targets, without altering native nucleic acid sequences. Founded in 2017 by Flagship Pioneering following breakthrough research by world-renowned experts in the field of epigenetics, Omega is led by a seasoned and accomplished leadership team with a track record of innovation and operational excellence. The Company is committed to revolutionizing genomic medicine and has a diverse pipeline of therapeutic candidates derived from its OMEGA platform spanning oncology, regenerative medicine, multigenic diseases including immunology, and select monogenic diseases.

For more information, visit omegatherapeutics.com, or follow us on X (formerly Twitter) and LinkedIn.

Forward-Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements, including without limitation statements regarding the broad potential of precision epigenomic control, the potential of the Companys pipeline of therapeutic candidates, and upcoming events and presentations. These statements are neither promises nor guarantees, but involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements, including, but not limited to, the following: the novel technology on which our product candidates are based makes it difficult to predict the time and cost of preclinical and clinical development and subsequently obtaining regulatory approval, if at all; the substantial development and regulatory risks associated with epigenomic controllers due to the novel and unprecedented nature of this new category of medicines; our limited operating history; the incurrence of significant losses and the fact that we expect to continue to incur significant additional losses for the foreseeable future; our need for substantial additional financing; our investments in research and development efforts that further enhance the OMEGA platform, and their impact on our results; uncertainty regarding preclinical development, especially for a new class of medicines such as epigenomic controllers; potential delays in and unforeseen costs arising from our clinical trials; the fact that our product candidates may be associated with serious adverse events, undesirable side effects or have other properties that could halt their regulatory development, prevent their regulatory approval, limit their commercial potential, or result in significant negative consequences; the impact of increased demand for the manufacture of mRNA and LNP based vaccines to treat COVID-19 on our development plans; difficulties manufacturing the novel technology on which our epigenomic controller candidates are based; our ability to adapt to rapid and significant technological change; our reliance on third parties for the manufacture of materials; our ability to successfully acquire and establish our own manufacturing facilities and infrastructure; our reliance on a limited number of suppliers for lipid excipients used in our product candidates; our ability to advance our product candidates to clinical development; and our ability to obtain, maintain, enforce and adequately protect our intellectual property rights. These and other important factors discussed under the caption Risk Factors in our Quarterly Report on Form 10-Q for the quarter ended September 30, 2023, and our other filings with the SEC, could cause actual results to differ materially from those indicated by the forward-looking statements made in this press release. Any such forward-looking statements represent managements estimates as of the date of this press release. While we may elect to update such forward-looking statements at some point in the future, we disclaim any obligation to do so, even if subsequent events cause our views to change.

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Today is International 15q Day – ASBMB Today

Posted: at 3:02 am

Nov. 15 is internationally recognized as a day to raise awareness for 15q neurodevelopmental disorders, which is an overarching categorization for three distinct conditions: Angelman syndrome, Dup15q syndrome and PraderWilli syndrome. Each condition is unique, yet all are caused by a change or mutation in the 15th chromosome.

The National Library of Medicine estimates that Angelman syndrome affects one in every 20,000 people and PraderWilli syndrome affects one in every 10,000 to 30,000. Dup15q has an unknown frequency, and it is estimated that it could be as high as one in every 5,000 people.

Human male karyotype after G-banding. Chromosome 15 highlighted.

PraderWilli syndrome is caused by a genetic mutation of undefined mechanisms. Current research suggests that this mutation causes an inability to express paternal genes; this may be due to a child inheriting two maternal chromosomes (as opposed to one maternal and one paternal copy), a defect in the paternal gene that prevents proper expression, or a complete lack of paternal genes on the chromosome.

Typically, symptom presentation begins around 2 years of age, and disease presentation includes hyperphagia, poor responsiveness, underdevelopment and hypotonia. Hyperphagia often leads to obesity, which means that individuals with the syndrome maintain a higher risk of experiencing obesity-related complications such as Type II diabetes, high blood pressure, elevated cholesterol and heart disease. Additionally, decreased hormone production due to underdevelopment may lead to complications including sterility and osteoporosis.

The critical region for PraderWilli Syndrome is located at chromosome 15(q11-13), in which exon 1 is a key region for imprinting. In PWS, exon 1 is maternally imprinted, meaning that paternal allele expression does not occur. Genetically, this can be caused by one of three things: deletion of a critical region, uniparental disomy or an imprinting center defect.

Deletions: Deletions causing PWS are categorized as either large, small or microdeletions. Large deletions are often between 4 to 6 Mb and occur in one of two regions. Deletions extending from the D15S541 region to the D15S12 region are often considered class I, while those ranging from D15S543 to D15S12 are categorized as class II. These are collectively the most common type of deletion observed in PWS, and both ultimately inhibit the functions of the imprinting center. Small deletions occur within a smaller range, and microdeletions often occur in areas such as an SNRPN gene exon 1 deletion, which is also known as an imprinting center mutation or defect.

Imprinting center defect: ICD is a subset of deletions most commonly known for deletion of imprinting region exon 1. At the moment, the only available method of detection for an ICD is through DNA testing.

Uniparental disomy: UPD is primarily characterized by a lack of paternal input. In one of the most common forms of the condition, chromosome 15 displays only maternal copies. This condition is often referred to as UPDmat and occurs through a mechanism known as trisomy rescue, in which a combination of a meiotic and somatic abnormal events results in either a heterodisomy or an isodisomy.

Angelman syndrome is often caused by issues with the ubiquitin ligase UBE3A gene located on chromosome 15q. This condition commonly occurs due to activation of only the maternal copy of the gene, with either a missing or defective paternal gene; however, it can also be caused by the inheritance of two paternal genes.

Symptoms of AS can first appear around six to 12 months of age and can include difficulty walking, lack of speech and seizures, among others. There is currently no known cure for the condition.

Current research focuses on the development of mouse models as a way to better understand the development and progression of AS. Humans and mice have similar UBE3A loci, which makes the mouse a viable preclinical model preceding the production of potential translational therapeutics.

Dup15q Syndrome, also referred to as maternal 15q duplication syndrome, is a condition caused by the presence of at least one extra chromosome 15 region (15q11.2-q13.1). Dup15q typically only occurs when the duplicate copy is maternally inherited.

Some common characteristics of Dup15q syndrome include hypotonia, intellectual disabilities, autism spectrum disorder and epilepsy. Currently, treatment options for the condition are limited to treatment of specific symptoms and surveillance, as well as genetic and prenatal testing to monitor development throughout pregnancy.

There are two forms of Dup15q syndrome that are commonly recognized:

Maternal isodicentric chromosome 15: In this form of Dup15q syndrome, two extra maternal copies of 15q11.2-q13.1 are present, which results in tetrasomy. This form of the condition accounts for approximately 60% to 80% of Dup15q syndrome diagnoses.

Maternal interstitial duplication: This subset of the condition is characterized by the presence of one additional copy of 15q11.2-q13.1, resulting in trisomy for this region of chromosome 15. Maternal interstitial duplication is less common than isodicentric chromosome 15 and accounts for only about 20% to 40% of diagnoses.

The 15q chromosome contains several regions known as segmental duplications, which have a higher susceptibility to rearrangement and thus mutation. Several genes of interest that may contribute to disease progression have been observed in this region, including UBE3A, GABRB3, GABRA5, GABRG3, and HERC2.

UBE3A: This is the same gene that is affected in Angelman syndrome. However, in Dup15q syndrome, it is suspected to play a role in symptoms including intellectual disability, anxiety and a reduced threshold for seizures, which is likely due to an increase in neuronal expression of the gene.

GABRB3, GABRA5 and GABRG3: These genes encode for receptor subunits of the GABAa receptor, a ligand-gated ion channel that plays a major role in synaptic transmission throughout the central nervous system. It has been suggested that this gene may therefore play a role in seizures during Dup15q symptom presentation.

HERC2: This gene is an E3 ubiquitin ligase, part of a subset of genes responsible for interaction with E2 ubiquitin enzymes and a corresponding target protein in order to accomplish transfer of ubiquitin from E2 to the protein. Current literature suggests that pathogenic variants of this gene may lead to neurodevelopmental complications, which is supported by the increased neuronal expression of HERC2 in individuals with Dup15q syndrome.

Treatment of PWS often includes approaches such as establishing nutritional supplementation for infants, human growth hormone treatment, sex hormone treatment, implementation of behavioral therapies and provision of mental health resources, among other possibilities. While there is not one streamlined approach for treating PWS, there is a repertoire of available resources that aid in early detection and improved quality of life.

AS does not have one specific treatment method. Therapeutic approaches focus primarily on addressing specific side effects of the condition, including seizures, anxiety and gastrointestinal complications, among others. This typically involves implementation of behavioral, dietary, physical or occupational therapies, as well as consultation with physicians to identify additional effective symptom management options.

Similar to both PWS and AS, Dup15q therapeutic approaches are highly diversified depending on clinical manifestation and disease progression. Employment of advice and care from clinical professionals is highly emphasized, and resulting care is individualized depending on the specific needs of each patient.

While there is still much to be discovered about 15q conditions, there are various resources available for those experiencing these conditions, as well as those who simply want to gain a deeper understanding of current clinical progressions toward treatment of PWS, AS and Dup15q syndrome.

This page on the Eunice Kennedy Shriver National Institute for Child Health and Human Development has resources for patients, researchers and physicians about PWS. It includes information about patient advocacy groups, foundations that support elimination of PWS, and organizations that offer support to patients and family members experiencing PWS diagnosis.

The Angelman Syndrome Foundation offers information about behavioral resources, counseling and familial support. It also has a podcast, which provides education about the condition.

The Dup15q Alliance is an organization that provides information about current research, clinical trials and even volunteer opportunities to foster a greater, more widespread understanding of Dup15q syndrome.

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Evolution of taste: Sharks were already able to perceive bitter … – EurekAlert

Posted: at 3:02 am

A research team from the University of Cologne, in collaboration with colleagues from the Leibniz Institute for Food Systems Biology in Freising, has discovered a receptor for bitter taste in twelve different cartilaginous fish (sharks and rays). The receptor belongs to the so-called taste receptors type 2 (T2R), which also make humans perceive bitter and potentially toxic foods. Until now, it was assumed that such receptors only occur in bony vertebrates. The work was published under the title A singular shark bitter taste receptor provides insights into the evolution of bitter taste perception in the renowned journal Proceedings of the National Academy of Sciences (PNAS).

In the past, molecular research has had limited information on sharks, as their genomes are often relatively large. Therefore, sequencing is often more complex and takes longer than with many other animals. However, the techniques are more advanced nowadays, providing ever more information on the gene sequences of many cartilaginous fishes. This enabled the neurobiologists lecturer (Privatdozent) Dr Maik Behrens and Tatjana Lang from the Leibniz Institute for Food Systems Biology and Professor Dr Sigrun Korsching at the Institute of Genetics of the University of Cologne to specifically search for bitter taste receptors in cartilaginous fish.

Twelve out of seventeen cartilaginous fish genomes studied contained genes for the taste receptors type 2, with only one T2R gene present in each species. The researchers named this single gene T2R1. The fact that only a single T2R gene was found suggests that it is the original form of these bitter taste receptors, which was not altered by gene duplication and subsequent different specialization of the resulting receptors.

'These findings give us new insights into the evolution of these receptors: We can look back almost 500 million years on the molecular and functional origin of an entire family of bitter taste receptors. Because that is how old the last common ancestor of cartilage and bony fish is,'says Sigrun Korsching. The authors have also introduced the T2R1 gene of the bamboo shark (C. plagiosum) and the catshark (S. canicula) into immortalized cell lines. The results showed that both sharks can taste bitter substances also perceived by humans, such as colchicine or bile acid. A screening of ninety-four human bitter substances identified eleven substances that could also activate the sharks receptors. Some of these eleven substances also activate the bitter taste receptors of the living fossil coelacanth (Latimeria chalumnae), an ancient species of bony fish, as the authors have shown in a previous study. Sigrun Korsching summarizes that 'the extent to which this function has been conserved is astonishing, i.e. through the entire evolution of vertebrates.'

Proceedings of the National Academy of Sciences

A singular shark bitter taste receptor provides insights into the evolution of bitter taste perception

13-Nov-2023

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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Cosmic Chameleon: Galaxy’s Stunning Transformation by Hubble Filters – SciTechDaily

Posted: at 3:02 am

Hubble Space Telescope image of the barred spiral galaxy NGC 1385, located about 30 million light-years away. Credit: ESA/Hubble & NASA, R. Chandar, J. Lee and the PHANGS-HST team

The barred spiral galaxy NGC 1385 appears in two strikingly different Hubble telescope images, attributed to the use of various specialized filters.

This luminous tangle of stars and dust is the barred spiral galaxy NGC 1385, which is located approximately 30 million light-years from Earth. The same galaxy was the subject of another Hubble Picture of the Week (see image below), but the two images are notably different. This more recent image has far more pinkish-red and umber shades, whereas the former image was dominated by cool blues. This chromatic variation is not just a creative choice, but also a technical one, made in order to represent the different number and type of filters used to collect the data that were used to make the respective images.

Hubble Space Telescope image of spiral galaxy NGC 1385, located 68 million light-years away from Earth, in the constellation Fornax. Credit: ESA/Hubble & NASA, J. Lee and the PHANGS-HST Team

It is understandable to be a bit confused as to how the same galaxy, imaged twice by the same telescope, could be represented so differently in two different images.

The reason is that like all powerful telescopes used by professional astronomers for scientific research Hubble is equipped with a range of filters. These highly specialized components have little similarity to filters used on social media: those software-powered filters are added after the image has been taken, and cause information to be lost from the image as certain colors are exaggerated or reduced for aesthetic effect.

In contrast, telescope filters are pieces of physical hardware that only allow very specific wavelengths of light to enter the telescope as the data are being collected. This does cause light to be lost, but means that astronomers can probe extremely specific parts of the electromagnetic spectrum. This is very useful for a number of reasons; for example, physical processes within certain elements emit light at very specific wavelengths, and filters can be optimized to these wavelengths.

Take a look at this weeks image and the earlier image of NGC 1385. What are the differences? Can you see the extra detail (due to extra filters being used) in this weeks image?

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Today’s Photo from Ted Grussing Photography: Tweaking … my … – Sedona.biz

Posted: at 3:02 am

I sold many of the photos off the walls of my home and I have spent time pondering whether to replace them or go with new photos to replace them. So far, I have decided to replace them, but have done some minor tweaking of the images before placing the orders these are two of the ones that will be going back on my walls.

The upper photo is a shot that I took years ago while flying through a monsoon storm over Sycamore Canyon on the way back to Sedona it was an incredible day with some intense storm cells and openings that let sunshine pour through and light up the rocks the once in a lifetime shot.

Below is a composite that I did years ago too, but it remains one of my favorites the primary photograph is an aerial shot taken east of the SF Peaks and Sunset Crater poked up through a low cloud layer that extended all the way to the Grand Canyon add to that portions of a Hubble telescope shot blended with it to bring the mysteries of the universe to the fore.

The new Webb telescope has made recent discoveries that call into question the widely accepted theory of an ever-expanding universe wherein galaxies and stars within galaxies are all retreating from each other so that in the distant future night skies would be black and devoid of light. Now, perhaps there is a newer and brighter future to look forward to

A new day in another new week it sure is nice to be here. Have a beautiful day and choose joy, smiles and life.

With joy!

Ted

Let us forgive much, forget more; Let me close my eyes and fall half asleep, That the pictures may grow softer and stiller, And the life, O thou God! again grow gentle.

excerpt from I Ponder Oer Love by Max Ehrmann

###

The easiest way to reach Mr. Grussing is by email:ted@tedgrussing.com

In addition tosales of photographsalready taken Ted does special shoots for patrons on request and also does air-to-air photography for those who want photographs of their airplanes in flight. All special photographic sessions are billed on an hourly basis.

Ted also does one-on-one workshops for those interested in learning the techniques he uses. By special arrangement Ted will do one-on-one aerial photography workshops which will include actual photo sessions in the air.

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The science of exploration through photography The Durango … – The Durango Herald

Posted: at 3:02 am

Greetings, stargazers.

In 1995 the Hubble science team released the image of the Pillars of Creation. This photograph fundamentally changed the way most of us think of astrophotography. Yes, the high resolution and image details were quite impressive, but it was the color palette that made this image unique. I have written individual columns about nebulae, astrophotography, astronomical filters, and a bit of spectroscopy, but these topics all come together to create these assigned color photographs.

The Pillars of Creation are part of the Eagle Nebula, which was discovered in the eighteenth century and is the 16th object on Charles Messiers list of fuzzy things that are not comets. It was first photographed in the late nineteenth century and had been a regular late twentieth century target for astronomers using film cameras. While the first images were black and white, color film can produce some really nice images that would match (at least somewhat) what we might be able to see with our naked eyes if they were sensitive enough.

Because the Hubble telescope was primarily a science mission, there was great interest in studying the composition of the universe by looking at specific wavelengths of light. Each element has its own unique spectral signature, or fingerprint, so looking for a certain wavelength of light associated with a specific element will reveal the distribution of that element. For example, excited hydrogen atoms emit a prominent red line at 656 nanometers, and taking a photograph through a filter that passes 656 nanometer light will show the distribution of hydrogen atoms.

Narrowband filters are made by building up multiple layers of dielectric coatings on a glass surface. These coatings are the same as the anti-reflective coatings you can get on your eyeglasses, but by using specific thicknesses and layers, selected wavelengths of light can be allowed to pass through, while others are reflected.

Instead of simply looking at one element at a time, it is possible to associate an element to one of the red, green, or blue portions of a 3-color photograph. In what is now called the Hubble Palette, a line of sulfur was assigned to be red, a line of hydrogen was assigned to be green, and a line of oxygen was assigned to be blue.

Narrowband filters are now readily available, although they are not cheap. As the quality of digital cameras has improved over the last couple of decades, so has the quality of Earth-based narrowband images. It is easy to recognize narrow band images because of the vivid colors, instead of the overall magenta tones from hydrogen gas seen in natural light.

As the use of the Fort Lewis observatories continue expanding, I hope that more of these narrowband images will be produced locally.

Hubble image updates

https://hubblesite.org/contents/news-releases/2015/news-2015-01.html

Astronomy picture of the day

http://apod.nasa.gov/apod/

An Astronomers forecast for Durango

http://www.cleardarksky.com/c/DrngoCOkey.html?1

Old Fort Lewis Observatory

http://www.fortlewis.edu/observatory

hakes_c@fortlewis.edu

This month

Charles Hakes teaches in the physics and engineering department at Fort Lewis College and is the director of the Fort Lewis Observatory.

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Michel Valentin: Political correctness and swastikas – Missoulian

Posted: at 3:01 am

Symbols are important, especially in our digital, inter-connected, high-tech civilization.

Although knowledge is supposedly at our fingertips, a motley convergence of negativism based on ignorance, intolerance, and reactionary politics, and positivism motivated by neo-puritanism, identity politics and political correctness wants to erase, destroy, and censor everything deemed controversial. To make things worse, the algorithmic, consumer-based logic governing the a-/social media helps polarize people by spreading the malevolent prejudices of partisan politics or the absolutist judgements of nave progressivism. Both force their black-and-white conclusions on an already confused public.

But sometimes, reason prevails, as the recent UMs swastika issue illustrates (Left-facing swastika symbols to remain on UM building for education, Missoulian Nov. 7). The decision to de-construct (Derridas meaning) the swastika by adding an interpretative sign next to it for those who ignore religious symbolism makes sense.

The swastika goes back to time immemorial, long before recorded Western history. Tibetan, Hinduist (God Ganesh), Persian, Basque, North American (Hopi, Navajo), and Meso-American cultures, to name only a few, used the swastika. They are literally everywhere in different forms: pictographs, pottery design, friezes, weaving patterns. Most are square and geometric; others are rounded and wave-like. Some archeologists even claim that they were Atlantis sign. Galactical symbolization, cosmic allegory, labyrinthine metaphor, life/death cycle representationWho knows?

Two kinds exist. One clockwise (swastika) symbolizing death; the other counterclockwise (sauwastika) symbolized life good fortune in Sanskrit and Japanese. Both signs had nothing to do with Nazism. Then why did Hitler choose it in 1920 as a Nazi symbol ruining its mystery for everybody? Some historians established that a strange relationship existed between Nazi ideology and European occultism. Nazis fantasized that the swastika was an Aryan symbol, sign of racial supremacy.

The right thing to do is to reclaim the sign from Nazi abuse and defacement. People who want to erase the swastikas on UM buildings mean well, but they are motivated by misguided and simplistic emotions.

During World War II, the French flag, an emblem of national unity and rallying symbol, was used both by French fascists/Nazi-collaborators and by anti-Nazi rsistants. Should the French flag then, be jettisoned? Both Neo-Nazis and Socialist Democrats fly the American flag. Should a new flag be designed? The Torah, the Bible, and the Koran are both used/abused by fundamentalist Jews, Christians and Muslims to fuel hatred. Should one ban these books?

By the same token, some Nazis loved classical music. Should it be banned? Or preceded by interpretative messages? Many great writers had fascist tendencies. Should they be banned? Remember the Heidegger controversy.

Decades ago, Rabelais, a giant of European literature, was banned from the UM Freshmen Humanities Program because Gargantuas Panurge wanted to fortify Paris medieval walls with callibistrys (vulvas). We could go on and on Everybody has reasons to be unreasonable, intolerant, irrational, and to censor (of course) the other.

Man is neither angel nor beast, and the misfortune is that he who would act the angel acts the beast. Pascal.

One really disturbing thing though, in this entire well-meaning brouhaha. Not one religious leader, faculty member, or student, ever protested, or even mentioned the demise of the Humanities (philosophy/history/foreign languages /English/religions/sociology/mathematics) at UM.

What about a plaque cemented on the brand-new Art Museum explaining what UM used to be 12 years ago, and what it has now become, after the great re-alignment/re-prioritizing complete and replete with the number of Humanities professors gone?

Lux et Veritas has become Obscuritas et Machinatio.

Michel Valentin is a retired UM professors/EPIS researcher/writer.

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Letters to the Editor | Nov. 12, 2023 – The Philadelphia Inquirer

Posted: at 3:01 am

Choose wisely

Congratulations to Mayor-elect Cherelle Parker. I am not a political science major, however, I believe she won the race to become Philadelphias 100th mayor based on her determination to combat the daily violence that plagues the city. Selecting the new police commissioner will be her most difficult decision. Checking off political correctness boxes must be part of the choice. She must look for someone who brings a crime-fighting strategy to the table. Someone who can work with the Fraternal Order of Police. Someone who can connect with the men and women who actually do the job, the street cops. Probably most important of all, someone who can repair the damaged morale within the Police Department, including the top brass. Unlike her predecessor, Parker must choose someone who is capable and can meet these challenges. She owes it to the people who voted for her.

William D. Markert Jr., retired, Philadelphia police captain, Warminster

An Associated Press article published by The Inquirer notes that the Group of Seven called for the unimpeded delivery of food, water, medicine, and fuel to Gazans. Such calls are invariably directed at Israel. Somehow, nobody mentions the extensive stockpiles of those very items in the terror tunnels that Hamas likely built using previous humanitarian aid extended by the West. The G7 should demand the release of the hostages, as well as the hostage supplies that Hamas is keeping for itself. Hamas is responsible for all the suffering in Gaza. It must be held accountable by the West.

Kenneth Gorelick, Wayne

We all want the bombing of Gaza to stop, but it isnt just Israel that is involved in this war. Hamas has responsibilities and choices, too. It has started a war that it cannot win. Heres a solution: Hamas surrenders. Lays down all its arms. Turns over all its war criminals all of them to the International Criminal Court, rather than to Israel. The ICC doesnt assign the death penalty, just some term of imprisonment in a European prison. The accused get taken to the Netherlands and are held while their cases are investigated and tried. There is heaps of video evidence of who did what.

The United Nations could propose this, and Hamas could accept out of humanitarian concern for the people of Gaza. Hamas isnt like ISIS. It didnt recruit from all over the Muslim world. The people in Gaza are, after all, the families, friends, and neighbors of the Hamas soldiers. Israel would stop bombing. What the U.N. and the European Union and U.S. media all refer to as innocent civilians would no longer suffer loss of life and limb, house and home. So both sides could demonstrate the depths of their humanity by ending the war.

John S. Hill, Easton, Pa.

Join the conversation: Send letters to letters@inquirer.com. Limit length to 150 words and include home address and day and evening phone number. Letters run in The Inquirer six days a week on the editorial pages and online.

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How the free world can prevail – Geopolitical Intelligence Services AG

Posted: at 3:01 am

Free societies can thrive by rediscovering and acting on their strengths. Values, including those of personal responsibility, must be at the core of a revival.

After Russias full-scale invasion of Ukraine on February 24, 2022, it appeared that the United States and Europe had one clear policy toward Russia. NATO was again united and strong. Although military supplies for Kyiv were initially lackluster, unity prevailed on sanctions and support. The Ukrainians were defending themselves bravely and Russia faced a military and propaganda disaster. A Russian defeat was considered probable.

There was hope for improvement in the Middle East and the Abraham Accords allowed a rapprochement between Israel and the Arab world, starting with the United Arab Emirates and recently joined by Saudi Arabia.

Turkey brokered a grain export deal for Ukraine, normalized its relationship with Israel and worked toward resolving conflicts in the Caucasus and Caspian regions.

Although the theocratic regime in Iran brutally crushes any internal opposition, the mullahs managed to demonstrate a semblance of softer policy toward their enemy, Saudi Arabia, brokered by China.

These developments provided pleasant illusions of a West united against Russian expansionism, a more moderate Iranian regional policy and a silver lining of peace in the Middle East. But China and Russia remained elephants in the room. A utopian hope prevailed in Washington and the European capitals that a Sino-Russian alliance could be torpedoed and that third countries such as India and others mainly in the southern hemisphere could be convinced to take a stand, primarily against Russia. A victorious alliance of good democracies against evil autocracies was proclaimed. The G7 was revitalized to lead this crusade.

The Western response started promisingly. U.S. President Joe Biden and his European allies saw themselves as the saviors of liberal democracy and good in the world. Obviously, free and independent countries must fight to remain that way. Freedom is not granted, nor is the self-determination of countries. We must strongly support the independence of nations challenged by Russian imperialism and Chinese nationalism. It is also clear that we must resist the brutal systems prevailing in Iran, Russia and China.

But is the West willing and able to fight? In theory, the ability exists.

The beautiful but somewhat naive illusions nurtured over the last two years are starting to crack. The present crisis in the Middle East is a striking example. It is not only a regional conflict but also involves the major powers. This leads to patterns that mirror other existing or developing conflicts, such as Russia on Central Europe and the Indo-Pacific arena.

Geopolitically, we do not just have a conflict between free countries and aggressive tyrannies, as we had during the Cold War. We have increasingly assertive new and important players, not fitting any categories of the prevailing narrative of authoritarian vs. democracies. But this must not be the main problem.

The West must recognize its internal weaknesses. There is first a certain arrogance and hypocrisy in the lecturing of Western values. It tends to ignore other cultures while condemning its colonial past. Ironically, this paternalism is frequently considered a new form of colonialism.

Worse still is the increasing denial of the cultural and traditional foundations of Europe. These are based on Judeo-Christian values framed by Greco-Roman philosophy and law. It is also true that these notions were and are misused. But they were the basis that allowed the development from the Renaissance through the Enlightenment to achieve todays free societies. These traditions and developments allowed liberalism, democracy, separation of religion and state as well as the rule of law. The notion of personal responsibility was at its core. Freedom can only exist based on personal responsibility (a very strong notion in Christian teaching, however, one that is frequently ignored by churches and governments) and sheltered by the rule of law.

Mainly in Europe, this important basis is increasingly denied. Any mention of God or Christianity is abhorred in politics, as we have learned in numerous debates, including those on the acts of the European Union.

This loss of real values (not the prevailing political mantraof values) and personal responsibility reveals itself as a major weakness and threat to freedom, democracy and the rule of law. It is a political and institutional cancer. This loss of principles leads to overpowering technocratic structures. Institutions become ends in themselves. Political parties look for votes, rather than strive for the good of theres publica. The citizen becomes the subject of such institutions. Freedom is exchanged for an illusion of security.

The West is no longer persuasive.

The consequences are manifold. Advantageous standards that allowed the U.S. and Europe to become free and successful are overlooked. Other countries observe the decline. The West is not persuasive anymore. The biggest power, the U.S., is not able to put forth valid and convincing candidates for its highest office, while the situation in Europe is depressing and distressing. The political discussion becomes increasingly ideological as opposed to a positive debate of facts. It is also limited by the new creed of exaggerated political correctness, which, instead of avoiding hate speech, goes further and eliminates even the facts. This is a challenge to the freedom of expression. But itsecuresthe success of new parties, frequently branded as populists. They are generally marginalized by the established parties, who should instead be seriously trying to understand why large parts of the population vote for these so-called populists. In general, most voters do not participate in elections, a bad sign for the political class.

Politics has become a profession. This leads to an increasing distance between the ruling class and the people. A better exchange between politics and other professions should be achieved. The real concern is that it is mainly career politicians who sit in parliaments. They are nominated by their parties and become dependent on them. Their livelihood depends on reelection and allegiance to party doctrine. This limits their independence. Here a system of citizen-legislators would be advantageous.

To prevail, the present political system relies on a strong technocratic basis. The consequence is an oversized state that claims increasing accountability from its citizens. Excessive control and a stifling regulatory framework are dangerous steps. In this situation, the democratic system is somewhat analogous to autocratic systems. (Fortunately, in Western democracies, we can still criticize without going to jail.)

We must hope that the regenerative potential of freedom will grow in its crisis.

But what is the result when looking at the geopolitical situation and the position of the West? It really shows two spectrums: weak leadership and populism, as reelection becomes more important than accomplishment.

This is the real dilemma. The West loses its ability to be an example to the developing world. And this is the real challenge. Certainly, most countries such as India and other, mainly southern nations do not want to become dependent on Chinese Marxism. However, the West no longer presents a credible alternative with its value proposals. Demographic trends mainly favor the Global South. It would be good to support prosperous development without trying to enforce changes in culture and tradition.

Lets just take another example: the situation of Ukraine. This nation is fighting and suffering a huge toll in lives to preserve its self-determination. Rightfully, it is supported by NATO and the EU. The biggest risk for Kyiv, however, is to lose Western support. The possibility exists that weariness will grow, and weak Western leadership will feel compelled to force Ukraine into a dangerous cease-fire.

These weaknesses could result in a global loss of freedom. Autocracies and technocracies would rule globally.The Occidental culture has, however, outlived many challenges. We must hope that the regenerative potential of freedom will grow in its crisis.

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The Die Hard Survival Guide To This Year’s Office Holiday Party – Fisher Phillips

Posted: at 3:01 am

While you can debate all you want about whether 1988sDie Hardis a Christmas movie (it is dont fight us on this point), you cant disagree with the fact that the movie depicts one of the all-time most memorable office holiday parties in cinematic history. A band of thieves posing as terrorists crash the Christmas Eve party on the 30th floor of Los Angeles new Nakatomi Plaza to rob millions in negotiable bearer bonds, only to be thwarted by party guest and New York City cop John McClain (played by a very young Bruce Willis). Besides being eminently re-watchable, the movie also provides valuable instruction on how to throw a proper office holiday party.

The folks at the Nakatomi Corporation did some things right and some things wrong when it comes to hosting annual holiday festivities. If you learn from their example this year, youll enjoy the holidays knowing that your office party wont lead to any human resources disasters or lawsuits.

Can I Get You Anything? Food? Cake? Some Watered-Down Champagne?

Any discussion of office holiday parties has to start with a discussion about alcohol the cause of many an HR headache. The alcohol was certainly flowing at the Nakatomi party: the moment McClain stepped into the office, a roving bartender offered him a glass of mystery punch. While theres nothing inherently wrong with having alcohol available at a holiday party, there are some established best practices when you throw adult beverages into the mix.

First, lets look at two of the things that Nakatomi did that you should emulate.

But there is a long list of things that Nakatomi could have done to handle its liquor better, so to speak. We have no idea if they offerednon-alcoholic alternativesto the guests. In fact, manager Holly Gennaro encourages her very-pregnant assistant Ginny to have some champagne, which is one of the more cringe-worthy moments of the movie. They also serve amystery punchto their guests, which (like spiked eggnog) is never a good idea. If your guests dont know what theyre drinking or how much alcohol they are consuming, they are more likely to become inebriated. Along those lines, shots are a bad choice nearly 100% of the time.

Another problem: the liquor flows freely with no oversight or limitations. In contrast, you might consider establishing adrink ticket systemso that your guests are limited in their alcohol consumption, are less likely to become drunk, and more likely to leave the party with their dignity fully intact. Moreover, you should aska few managersto forego drinking for the night. They can spot problems before they get out of hand, and hang out near the exit doors to prevent people from driving home if they walk out of the party more lit than the holiday tree.

We never find out if Nakatomi planned toclose the bar earlybefore the end of the party (as, alas, their party ended prematurely when Gruber and his boys roll up), but you should shut down access to alcohol about an hour before the end of the festivities to help your guests sober up so that they leave filled with holiday spirit, not alcohol and spirits. You can even hold an awards ceremony, make special announcements, or give away door prizes near the end of the evening to keep people sticking around.

Mr. Mystery Guest Are You Still There?

Guests at the office holiday party are a mixed bag our job is to let the good ones in and keep the bad ones out. Nakatomi Corporation made one smart move in this regard: theyinvited spouses and significant others to attend(well, at least one spouse that we know of).

Employees significant others do some of the babysitting for you, as their attendance will reduce the chances of crude and unprofessional behavior among your workforce. People tend to make more scrupulous choices when they are in the presence of loved ones. Likewise, those loved ones are likely to pressure their counterparts to act right.

At the same time, you should do your best toprevent unwanted gatecrashersfrom attending. It is doubtful that a band of well-armed European safe-crackers will crash your party, but it is possible that your employees friends might decide to stop in for the fun if nobody is guarding the door. That can be a recipe for trouble. Nakatomi stationed a building security guard in the lobby to admit known guests. Likewise, you should have someone make sure that the only people who are enjoying your party are invited guests.

Welcome To The Party, Pal!

Attendance at your party should bevoluntary, not mandatory. After all, you might have some employees whose religious beliefs prevent them from celebrating holidays. Or you might have those in recovery who would prefer not to be in the presence of liquor. Nakatomi violates this rule by holding the party at the office at the end of a workday (Christmas Eve, no less!), so if you do the same, make sure you let your employees know they dont have to stick around if they dont want to.

At the same time, dont be a Scrooge and make your employeeswork during the party. At the beginning of the movie, the party is already in full swing, and Gennaros assistant Ginny is still hard at work finishing up some paperwork while everyone else is having a good time. Besides being a possible wage and hour problem, this approach will surely kill everyones holiday vibe. If you want loyal employees with good morale, dont make them work late and miss the party.

Yippee-Ki-Yay, #$@&%*!

The whole point of hosting a holiday party is so that you can thank your employees and collectively have a good time with them. And while you dont want to be a party pooper, you also dont want the party to be so wild that it later becomes the festive centerpiece of a lawsuit. You should send a communication to all of your employees in advance of the party reminding them to keep it classy, aswork rules still applyduring the festivities.

This means that you should not tolerate untoward humor, illegal drug use (as demonstrated by the smarmy coworker Harry Ellis in someone elses office), sexual innuendos or misconduct (such as the amorous couple spending time in the private office), or any other unprofessional behavior. Let your employees know that they are still subject to your regular policies and that violations could lead to disciplinary consequences.

Im ArgyleIm Your Limo Driver

Another solid move by Nakatomi was hiring a private driver for their guests (or at least for McClain). Argyle the limo driver picked McClain up from the airport and was on standby to drive him wherever he needed to go after the party was over.

Were not saying you need to rent a fleet of limousines to chauffeur your guests around, but you shouldoffer rides to all attendees who are departing the party. You can pay for taxis or set up ride-share cars via a corporate account to make payment easy and rest easy knowing that you wont be held responsible for any injuries or deaths caused by drunk drivers. This extra expense is the best insurance to keep your employees and the general public safe and spare you from costly liability claims.

Now I Have A Machine Gun. Ho Ho Ho

The most memorable holiday decoration in the film was the plain, grey sweatshirt worn by one of the criminals, which McClain transformed post-mortem into a classic ugly Christmas sweater with a red Sharpie marker. But keen observers of the film will also note that Nakatomi also set up a few tastefully appointed Christmas trees around the office. Should you be worried if you want to set outholiday decorationsat your office party?

Although you may be concerned about political correctness run amok, you will be happy to hear that the Equal Employment Opportunity Commission (EEOC) has said that typical Christmas decorations wreaths, trees, holiday lights, Santa and reindeer, etc. are secular symbols and do not automatically create a religious discrimination situation in your private workplace. However, the EEOCs words of caution from its Compliance Manual are worth noting: As a best practice, all employers may find that sensitivity to the diversity of their workplace promotes positive employee relations. In other words, take the specific dynamics of your workplace into account before decorating for the holidays.

Regardless of your office dynamics, the cardinal rule of office holiday decorating isno mistletoe. Careful viewers will see that Nakatomi followed this rule: although they might have a legacy of greed around the globe, at least they knew well enough not to hang what amounts to an invitation for a sexual harassment lawsuit in the office. Avoid the mistletoe and avoid the problems it will inevitably create.

Nice Suit. John Phillips London. I Have Two Myself.

Certainly every workplace varies in its location on the style spectrum. Some offices embrace a more business casual, John-McClain-like approach with simple slacks and plaid button-ups. Others are more formal and favor black on black and expensive suits (perfectly coordinated with Heckler & Koch HK94 machine guns, which should be unwelcome at your holiday party and every other day at your office).

Regardless of your companys normal style, you should still maintain some semblance of a dress code, and your employees should stick with outfits that they would normally wear to work. You should communicate to your employees that they should dress appropriately since it is a work-related event. Revealing clothing is for the night club. Bloody, white muscle tanks are for fighting German terrorists. Neither of those styles have a place at the office holiday party.

Its Just A Small Token of Appreciation . . . Its A Rolex

Maybe youre thinking that all of this holiday party business sounds more like an obstacle course where you have to outmaneuver employees who are ready to hit you with a lawsuit. If you have an antisocial or poorly behaved workforce, it may be better to show your appreciation in a different way. Holly Gennaro was rewarded for her hard work for the year with a Rolex, for example. Your budget may not contemplate your employees walking out of the office dripping in company-gifted diamonds, but there are alternatives.

Some employees might prefer to take the time that would be otherwise spent at the party as PTO. You could also take the money that you would normally spend on the party and issue bonuses, gift cards, or other treats. Just remember that if you go this nontraditional route, any tangible gifts you offer up should be treated as supplemental wages subject to payroll and income tax.

Conclusion

Please contact your Fisher Phillips attorney with any questions about throwing this years company holiday party. We will continue to monitor the latest developments and provide updates as warranted, so you should ensure you are subscribed toFisher Phillips Insight Systemto gather the most up-to-date information.

The author would like to point out that, to the extent you arent convinced thatDie Hardis a Christmas movie, one of the main characters of the film is named Holly a clear reference to the prickly, green Christmas shrub.

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The Die Hard Survival Guide To This Year's Office Holiday Party - Fisher Phillips

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