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Monthly Archives: May 2023
Airstreams new travel trailer fits a swanky studio apartment into less than 17 feet of living space – The Manual
Posted: May 18, 2023 at 1:10 am
Few brands symbolize the Great American Road Trip like Airstream. On the outside, its iconic aluminum travel trailers have changed little since the last century, and for our money, thats a very good thing. Across the lineup, however, the interiors have evolved into something altogether different. Theyre more polished, more luxurious even downright swanky and were not talking about just the flagship models that sell for well north of $150,000.
The new Airstream Caravel 16RB offers many of the same upscale features and specs of its pricier brethren in one of the companys most compact footprints ever. But dont let the diminutive size of this Airstream camper fool you. Airstream managed to pack all the amenities of a modern luxury apartment into just under 17 feet hows that for van life?. That has us seriously reconsidering our current living situation.
The Caravel name isnt new. In fact, it was released alongside the beloved Bambi way back in the 1960s when Airstream began toying with the idea of lighter, single-axle RVs. But Americans wanted much, much bigger campers back then, and so the models fizzled out. Fast forward a few decades, when most of us are planning our travels (and our lives) with the environment and minimalist living in mind, and Airstream re-released both of these compact RVs in 2019.
On an initial walk-around of the latest Caravel 16RB, it doesnt appear to have changed much since Kennedy was in office. Its true that Airstream kept the handsome and timeless look of its popular riveted aluminum design. Its all wrapped in 10 large windows that bathe the interior in sunlight. Plus, at around 3,500 pounds, its light enough for most medium-sized SUVs to tow it.
Inside, however, the tiniest Caravel feels like an ultra compact studio apartment on wheels. The raw aluminum cladding carries through, giving it a clean, modern industrial feel. Airstream makes clever use of space to delineate between the sleeping, dining, and cooking areas. Theres a full-sized memory foam mattress with a hanging closet the dinette converts into an additional sleeping area (for a total of four adults) and the kitchen boasts a sink and two-burner cooktop all impressive considering its 16.5-foot length. Theres even a separate bathroom with a standing shower.
What truly sets the Caravel (and most other Airstreams) apart is the attention to detail. Theres a long list of tech convenience features baked into this latest model. That includes dimmable, energy-efficient LED lighting and a QuietStream climate control system. Plus, digital nomads will dig the integrated four-speaker JL audio system and TV with an omnidirectional antenna. There are plenty of places to plug in, too, via multiple USB ports and standard 110-volt power outlets throughout. You can keep it all topped up with an optional 100-watt solar package for going off-grid.
The entry-level Caravel 16RB starts at $74,000, making it one of the most affordable full-featured Airstream models on the market. Really, only the pared-down Airstream Basecamp is significantly cheaper, but its a whole different animal, so its impossible to compare the two. If youre looking for a little extra legroom and even more amenities, the Caravel model lineup also includes 19-, 20-, and 22-foot models. Whichever model you opt for, just promise to take us with you. Well bring the snacks.
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Steven Wright, Master of the One-Liner, Tries His Hand at a Novel – The New York Times
Posted: at 1:10 am
If theres one living stand-up legend whose jokes are perfect for Twitter, its Steven Wright. Not only are they concise (Lost a buttonhole) but so meticulously absurd (I like to reminisce with people I dont know) that rapid shifts of context dont distort their meaning.
So it was a surprise that when he started an account in 2011, he didnt use it to try out punch lines, but to write a novel very slowly. It almost sounds like a Steven Wright joke. But more than a decade later, this larky experiment has turned into a book, Harold, abouta meandering, bizarrely charming day in the life of a 7-year-old boy.
In an almost stream-of-consciousness style from the boys point of view, Harold, which takes place in the 1960s when Wright was a kid, pingpongs from musings on a third-grade teacher to a daydream about going to the moon. Plenty of its sentences would not be out of place in Wrights standup: All art is modern art at some point.
Sitting in the Manhattan office of Simon & Schuster last month, Wright, who has been telling jokes in front of audiences for more than 40 years, explained in his signature gravelly drone that stand-up provided him a very narrow window of creativity. Not a criticism, hes quick to add, just a description of the appeal of the new, more expansive form. I wanted to put a funnel on Harolds head and pour everything I think about being aliveinto it, he said. Lawyers, religion, space. Everything.
Asked why he would focus on a boy, Wright shrugged. But he believes children notice things thatadults miss. He sounds almost jealous when he describes the uncluttered mind of a young person. A kid, he said, is like an alien who just got off a spaceship and is looking around.
Wright can resemble an alien himself. He seems as laconic and lyrical as he is onstage, except warmer and quicker to laugh. Metaphors pour from him like a Bob Dylan song come to life. When asked to describe Wright, Marc Maron texted me: Poet. Happens. Rarely. In. Comedy.
Theres no more storied example of Johnny Carson making an overnight star than when his booker, visiting colleges for his son, stumbled upon an unknown Steven Wright performing in a Chinese restaurant in Boston. Wright killed on The Tonight Show in 1982, when the studio audience alone was his biggest crowd yet. Three years later, Wright released I Have a Pony, a classic of modern stand-up.
If you came to it young, as many did and still do, it could rejigger your entire sense of humor. The comic Anthony Jeselnik told me Wright influenced everything about my comedy. Bobcat Goldthwait called him human pot, explaining, Listen to him long enough and you feel stoned and see the world as absurd and amused as he does.
Wright described his background as resolutely ordinary: middle-class, all-American, Norman Rockwell stuff. Sensitive, a little quiet, he didnt tell his family that he had been doing comedy for years. Wright calls his break a fluke.
Dont be fooled by this fairy-tale story. Wright not only had a gift for old-fashioned joke construction but also a rare discipline and taste that he remained stubbornly faithful to. Take one example: Ive always hated puns, he told me with a rare flash of passion that he chuckled at. It would be funnier if you dropped a dish.
Early on, he set up rules for his comedy that might have hurt him in the short term but have allowed his work to age as well as any comedians. He avoided anything topical. He also did not curse. I didnt want to get a bigger laugh because of that, he said. I wanted it to be pure.
Wright usually waves away any grand intent behind his work, saying his deadpan style is just how he talks. His old friends back this up. But maintaining a singular view of the world requires effort.
After living on both coasts, he moved back to New England to a rural spot one town over from Walden Pond. You can see your life better, he said of living near nature. At one point, he likened city life to being constantly pelted with candy. You cant think because youre just trying to get through the Raisinets.
Wrights monotone one-liners remain a touchstone for a comedy subgenre, along with the other master of deadpan, Mitch Hedberg, who died in 2005.
The biggest difference between Mitch and Steven is that when you saw an hour of Mitch, you got an idea of who he voted for, what he was about, said Goldthwait, who, like Wright, emerged from the Boston comedy scene of the 1980s. You watch Steven for an hour and have more questions about him than before you saw him.
This is why Harold holds a particular fascination for comedy fans. What more can we learn about the elusive Wright?
Theres a romantic streak mostly absent from his comedy. The Apollo mission to the moon looms large in the story, and Wrights father, an engineer, worked for a company that helped build parts for NASA. Seeing a camera wrapped in plastic that was heading for space at his dads workplace fired his imagination and was at one point a scene in the book. That was cut, but the thrill of space travel remains.
There is also more talk of love. Sometimes lustful, other times weary. Being in love was like being on a seesaw where one side contained nitroglycerin, he writes. When you first get on no one knows which side has it.
When Harold talks about a beautiful, intense New York girlfriend in his future, this sounds like something from the authors life. Wright said that was true but kept it oblique in the book and was loath to discuss his personal life. He never married (Romance is gambling, he told me) and, asked why he didnt have kids, he sounds like a bystander to his own life. Didnt think about it, then it didnt happen, he said. It wasnt decided. It just happened.
The most revealing thing Harold captures about Steven Wright is the way he thinks about thinking. Described by the author as a wondering machine, the boy ponders whether its possible to be in your 70s and have the perspective of a 5-year-old without being nuts? Steven Wright is 67 and says he performs less these days.
The books central metaphor is a description of Harolds thought process as a room with one window and a riot of birds flying around. Occasionally one flies out. That represents an idea. Its a view of creativity that is random and unpredictable. Isnt it a bit scary? What happens if the birds stop flying out?
Wright released relatively few specials in his career because, he said, I can only think of so much stuff. But he looked at ease with the idea that some things are out of our control. You can try to think of ideas, but your mind is running on its own. Or at least my mind, he said. Its mostly chaos, but youre organizing a lot of it.
Then he paused to smile and toss out one last metaphor: You have to stay on the road when you drive.
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Steven Wright, Master of the One-Liner, Tries His Hand at a Novel - The New York Times
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Poop falling from the sky: Here’s how often that happens – CBS News
Posted: at 1:10 am
MINNEAPOLIS --"It's a bird, it's a plane ... nope, it's poop!"
On May 15, residents of Burnsville, Minnesota were waiting in line at a Caribou Coffee drive-thru when their windshield was splattered with what they call "brown rain."
"The odor was so strong that the woman who was handing me my coffee noted how much it smelled," said Burnsville resident, Carisa Browne. "I mean, my cat had something similar to it this morning, so I've had a lot today with the poop."
"I had my A&P license, I went to school to be an aircraft mechanic, and I didn't know if there was even a way to release it mid-flight, so that's why I'm a little confused, I'm gonna look into it," said Browne. The Metropolitan Airports Commission says they are not aware of any incidents related to flight activity.
Browne did some Internet sleuthing and believes the culpable plane was a United Airlines flight to Denver. WCCO News reached out to United and got this response from their media relations department: "No reports on this from our end."
But mysterious substances falling from the sky are not totally uncommon.
In 2018, a 22- to 26-pound chunk of ice fell on the Fezilpur Badli village in India, startling residents. Some villagers thought it was an extra-terrestrial object, and even took samples home. A sample of the projectile was sent out for a chemical analysis, and a spokesperson for the International Aviation Authorities "strongly suspected" that the ice chunk was frozen airline excrement.
Luckily, in this 2018 case of flying excrement, no one was hurt.
A woman in central Madhya Pradesh in 2016 was not so lucky. She suffered a severe shoulder injury when she was hit by a football-sized chunk of ice that fell from the air and crashed through the roof of her house.
India and Burnsville, Minnesota are not the only places where there have been odorous objects reported falling from the sky.
In 2012, a Long Island couple were covered in "sludge" as a plane flew overhead. Another couple in Leicester, England also reported an incident where pungent "blue ice" hit their roof, broke apart, and landed on their heads.
So, what's the deal? Are airlines emptying their waste on us?
The short answer, is no...at least not on purpose.
Most airplanes are configured with a modern "vacuum waste system" that sucks waste and wastewater into a sealed tank below the craft. Once a plane lands, the ground crew dispose of sewage using a "honey truck" that siphons the waste and disposes of it into an airport's underground sewage system.
On a long-haul 747 flight, travelers may flush a toilet around 1,000 times, creating roughly 230 gallons of sewage. Sometimes, that can be too much sewage for a plane to handle, especially if it's malfunctioning. In those cases, waste can seep out of the tanks.
When a sewage tank or drain tube develops a leak, it creates what is referred to as "blue ice." Blue waste treatment liquids used in plane toilets turn to ice when exposed to freezing temperatures at high altitudes -- hence the name "blue ice."
Typically, blue ice gathers and stays on the outside of the aircraft, but sometimes it breaks off before landing. When it does break off, it often melts and evaporates before reaching the ground. Though, this depends on how high the plane is at the time it falls.
Waste leakages pose a serious concern for air safety. Aside from damage to homes and injury to people, blue ice has even caused damage to other planes. In one instance, blue ice knocked an engine off the wing of a plane.
This made us curious how do other ways of transportation dispose of their waste? The answers may shock you.
Cruise ships have been reported to routinely drop thousands of gallons of human sewage a day...most likely into whatever waterway they're sailing. An EPA survey found that cruise ships generate an average of 21,000 gallons of sewage and 170,000 gallons of graywater -- residual water that drains from sinks, showers, and laundry machines, often laden with detergents, oil, grease, food waste, and various pathogens -- a day.
There is a patchwork of federal, state, and international laws regarding how and where ships can dispose of their waste, but it's somewhat complicated.
For example, sewage needs to be treated if it's going to be flushed within three miles of U.S. coastline. Beyond that, it can be dumped in it's raw state. However, most cruise lines and trade associations have a policy against dumping untreated sewage anywhere.
What about trains? How do train lines dispose of their waste?
Until the 1990s, U.S. trains often drained their waste onto the tracks. When reaching stations, personnel would ask passengers not to use the bathroom. However, these days, most trains store waste in an onboarding holding tank.
But what about astronauts? How do they handle their "business"?
The answer is rather simple. Waste is either sent back to Earth or recycled.
Toilets on the International Space Station separate solid and liquid waste. Solid waste is tightly bagged and placed into an unmanned vehicle (known as a "Progress module") and is eventually returned to Earth, though burns up upon its re-entry into the atmosphere.
Since urine is 90% water, astronauts have found a way to put it to good use.
Liquid waste is boiled, distilled, and sent to a water processor where it undergoes a cycle of filtration and chemical purification until it can be used by the crew. Astronauts say, "Today's coffee istomorrow's coffee!"
However, recycling liquid waste is a relatively new procedure. Historically, urine would be ejected into space. Due to the low temperatures in space, wastewater would quickly freeze into small crystals.
Rusty Schweickart, an astronaut on Apollo 9, once described a urine dump at sunset as "the most beautiful sight in orbit."
Space programs stopped using this method of disposal due to waste turning into orbital debris. NASA has been refining their method of urine purification for the last 20 years.
"As we travel farther from Earth on Artemis missions to the Moon and build toward longer, crewed missions to Mars, it's inevitable we'll need more reliable hardware and a reduced requirement for spares," said Arthur Brown, deputy manager of ECLSS integration and development at NASA's Marshall Space Flight Center in Huntsville, Alabama. "Even from the space station, it's a long way to the nearest hardware store or machine shop."
All in all, rest assured that objects flying in the air are least likely to be Superman or human excrement, rather birds or planes.
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Poop falling from the sky: Here's how often that happens - CBS News
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How will we react when the aliens arrive? – The Irish Times
Posted: at 1:10 am
Most people in a position to hold a critical opinion on the matter think that biological life is not unique to planet Earth but that it has also arisen elsewhere in the universe, including intelligent life. So, how will we react if intelligent alien life visits Earth?
Much of what is written on the subject is preoccupied with what rights we should grant our alien visitors. But it seems to me that our most urgent preoccupation must be how to establish reliable two-way communication with the aliens.
At present, we have no evidence that life exists anywhere in the universe beyond Earth. However, our understanding of the nature of life on Earth, how life might have arisen from lifeless chemicals and how it evolved through Mendelian genetics to the present day, together with the fact that there are many planets elsewhere in the universe with physical conditions similar to Earth, emboldens us to confidently predict that life has arisen and evolved in many locations throughout the universe.
Aliens will, almost certainly, look very different from us. This is only to be expected when we consider the vast variety of animal body-plans evolution has produced here on Earth; many that look quite strange to the human eye, eg octopus, Japanese spider crab, star-nosed mole, blobfish, narwhal, aye-aye, naked mole rat and many more (google the photographs).
Most of what I read concerning how we humans should react to alien visitors relates to what rights we should grant them, assuming the visitors are sentient, ie able to feel and perceive, to show awareness and responsiveness and to experience pleasure and pain. Great concern is expressed by philosophers like Peter Singer that we should extend the same rights to sentient aliens that we extend to sentient non-human earthly life.
If aliens visit Earth, at least in the medium term, they will almost certainly be far more advanced than us, having solved the problem of interstellar space travel well before we have. It is also very probable that they will not only be sentient but far more advanced technologically and far more intelligent than us humans.
[UFOs are back in the skies over America. Did they ever go away?]
So, I think it would be more appropriate for us to ponder what rights the aliens would be prepared to grant to us rather than the other way around. Also, what if the advanced alien visitors were hostile towards us. Aliens with the capacity to cross vast interstellar distances to reach Earth would almost certainly have the firepower to destroy us in any conflict.
I think the critically important thing to prepare for in anticipation of aliens arriving here is how to communicate with them to ask them where they came from, why are they visiting us, what they want from us, etc. The fascinating 2016 sci-fi film Arrival explores this scenario establishing a two-way conversation with 12 alien spacecraft that suddenly appeared in Earths skies.
If intelligent alien life exists it may well be broadcasting its existence to the rest of the universe, probably via radio waves. An organisation called Search for Extraterrestrial Intelligence (SETI) Institute has been listening for such broadcasts using giant radio-telescopes since 1985, but has detected none.
SETI Institute is now debating whether, in addition to passive listening, it should also be broadcasting (Active-SETI) our existence to the universe. Active-SETI would be a risky undertaking because we might attract the attention of hostile aliens far more technologically advanced than ourselves.
[Are we alone in the Milky Way galaxy?]
Meanwhile, there are persistent reports worldwide of unidentified flying objects (UFOs) in our skies. Many people believe some of these UFOs are alien spacecraft the aliens are already here! This UFO phenomenon should not be dismissed as crackpot. Many strange sightings have been made, even filmed, by competent observers eg professional airline pilots. Governments have a duty to investigate these reports.
The Pentagon recently released a long-awaited 2022 Annual Report on Unidentified Aerial Phenomena (UAP) cataloguing 510 UAP reports gathered by agencies involved in the report and branches of the US military. UFOs are rebranded as UAP. The report assessed 366 of the most recent UAP reports. Twenty-six were characterised as uncrewed aircraft systems, or drones, 163 were balloons and six were airborne clutter like plastic bags.
One hundred and seventy UAP reports remain uncategorised and unattributed. Some of these displayed unusual flight/performance characteristics and require further analysis. It is good to see the US starting to take this matter seriously after years of media sensationalising UFO sightings.
William Reville is an emeritus professor of biochemistry at UCC
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Luxury stores with the most beautiful interiors – Luxebook
Posted: at 1:10 am
Luxury stores with the most beautiful interiors - Luxebook Luxury stores with the most beautiful interiors - Luxebook Arushi Sakhuja and Jade CrastoThe link between retail stores and architecture has always been very strong. For this reason, many brands have taken the help of several famous designers to design their luxury stores to make it an experience. The result? A series of boutiques around the world that look like art installations. LuxeBook takes you through the most remarkable and intriguing shop interiors from pool-inspired designs to opulent chandeliers and sculptures. Are you a design enthusiast? A traveller? Then these stores will leave you awe-inspired. Burberry Mykonos, GreeceBurberry GreeceThe Burberry pop-up store in Nammos Village gives you a glimpse of true Mediterranean aesthetic. Immersed in nature, the structure is presented with a palette of pistachio green and beige and is enriched with blue and pink summer shades. Throughout the store, fixtures and details are built with a variety of materials and textures, from plywood to mirrored, glossy finishes and a dash of greenery. The outdoor terrace features a wooden pergola inspired by traditional Mykonos buildings, with TB Summer Monogram blue siding. The ground floor features a blank canvas wall where visitors can add illustrations and custom tags, similar to the Burberry Bond Street store.Glossier, SeattleGlossier, SeattleLocated in the Capitol Hill neighbourhood and designed by Glossiers in-house team, the 2,800-square-foot retail space is the brands largest physical store to date. A large sculpture at the centre of the space is designed to look like a boulder covered in moss and colourful mushrooms, influenced by the flora of the Pacific Northwest region. This is based on a landscape installation created by designer Lily Kwong for the pop-up and a terraced hill is evoked by a stack of flat thin cushions upholstered in various green textiles and leathers along the large store windows. Walls around the store are finished in light-toned textured walls and beige and dusty-pink tiles cover the floor. On the exterior, doors and window trims are painted a dark blush hue to match the Glossier logo and contrast the buildings cream brickwork, making it look palatial. Aesop, Hong KongAesop, Hong KongAesop has added yet another store to its extensive retail network in Hong Kong. The store features an interior design by architecture practice Nadaaa from Boston. Evoking a refined state of construction, Aesop reflects an immersive sense of calm, by drawing on a neutral, natural palette. With extensive use of raw materials and exposed finishes, the store uses beams of reclaimed Oak shelves set on blackened steel frames, offering a wonderful textual interplay. An elongated sink of oxidised copper punctuates the sophisticated industrial aesthetic.Dolce & Gabbana Rome, ItalyDolce & Gabbana Rome, ItalyDolce & Gabbana is well known for its exaggerated designs that steer clear of sobriety. Over the years the brand has designed the image of a new Italian aesthetic in the world. Their boutique in Piazza di Spagna, in Rome, the heart of the Eternal City, the capital of Italian history and culture, could not be less. Housed within the walls of a majestic sixteenth-century palace, the shop looks like a real Roman temple made of marble, mosaics and frescoes. A digitalised fresco depicting Greek gods is the focal point of luxury fashion brands store. Set within a 16th-century palazzo the store reflects a city synonymous with magnificence and uniqueness. Circular mosaics have also been embedded into the high-gloss floors, inscribed with the words paradise, love and beauty.Selexyz Dominicanen Maastricht, NetherlandsSelexyz Dominicanen Maastricht, NetherlandsThe contemporary building interior of the Bookstore Selexyz Dominicanen was designed by Merkx+Girod architects in Maastricht, Netherlands for the Dutch booksellers Selexyz Dominicanen. Merkx+Girod were commissioned by the Dutch booksellers to convert the interior of the former Dominican Church in Maastricht into a modern bookstore. The interior design takes advantage of the spatial magnificence of the churchs architecture. To satisfy BGNs need for 1,200 m2 of selling space and given that the churchs floor area is of only 750 m2, Evelyn Merkx and Patrice Girod thought to insert an oversized walk-in bookcase. In order to preserve the character of the church while achieving the desired commercial square footage, the architects decided to insert an oversized walk-in bookcase where the books are kept. The lighting, which is an all but integral part of the stores design, manifests itself in the chorus by way of a traditional chandelier above the crucifix-shaped table located in the caf area.Gavello Nel Blu, Mykonos, GreeceGavello Nel Blu, Mykonos, GreeceGavello Nel Blu, designed by SAINT OF ATHENS, is a jewellery store with an interior that resembles a real swimming pool: light blue tiles. This jewellery shop on the Greek island of Mykonos was designed to resemble a 1960s swimming pool. Creative agency Saint of Athens worked with Dive Architects on the project for Italian brand Gavello to make the store stand out from its neighbours.As you enter the shop, you get the impression that you are swimming in an empty pool. The walls and floors are made of light blue tiles, and a ladder and beach balls stamped with the brands logo decorate this soothing world. There are also lockers to store your things and red and white striped cushions. The architects have also included other accessories such as mirrors, display cases, and display cones for an even greater vacation feel! Innovative, isnt it? The jewelry is displayed on a rectangular table in the centre of the store as well as inside four niches embedded into the blue tiled walls. The goal behind the design of this store was to show that with a few square meters, you can create a surreal and innovative space while still representing the image of a brand. That you can create a store in which you want to enter into.Moniker, OsloMoniker, OsloMoniker Fashion Universe, in Oslo, is a 1,500-square-metre concept store that Norwegian design studio Snhetta said is supposed to feel like a treasure hunt. Called Moniker Fashion Universe the 1,500-metre-square concept store is located in the heart of Oslos shopping district, near the newly renovated Valkyrien Square. Fixed partition walls create a maze of rooms set within a different visual universe built around different personality traits and based on, for example, space travel, motor racing and the French Riviera. Just like the womenswear department, which is split into five zones that are built around five different personality traits, Moniker Man is split into two distinct zones built around the character traits of sensitive and ambitious. Featuring striped fabrics, plenty of foliage and a lilac and yellow colour palette, Delons zone takes its design cues from the French Riviera. According to the studio, the playful design of this zone is designed to challenge our conception of what falls into the categories of feminine and masculine. In the ambitious zone, which pays homage to Paul Newman, the design team created a classic ambience through a luxurious material palette. This is contrasted with industrial materials that nod to the racing industry.Idli by Thierry Journo Jaipur, IndiaIdli by Thierry Journo Jaipur, IndiaExperience Jaipur through a contemporary lens at lifestyle boutique Idli, the brainchild of French designer Thierry Journo. The theatrical space features trompe loeil canopy and breezy palm tree murals, where handmade furnishings and hand-painted vases mingle with colourful fashion creations. The new store, on Subhash Marg, in C-Schemethe citys poshest residential areais filled with light and showcases his work at stints as a copyist at the Louvre, in collaborations with Thierry Mugler and Andree Putman, and as an illustrator for John Galliano.The space comes alive with doorways that are framed by striped, trompe loeil canopies, tropical palms and grass on the wall and paper lanterns in a rainbow of colours hanging from the ceiling. The entire effect is fantastical, quintessentially French. Sabyasachi, New YorkInto the world of SabyasachiSabyasachi built its first international store in the United States in the West Village of New York. The store is intended to depict Mukherjees trip from Kolkata to New York and to showcase the opulent richness for which his creations are recognised. The store reflects a classic look, suited to the modern customer, and is inspired by historic residences and palaces of the Indian metropolis. The corridors are filled from floor to ceiling with framed paintings influenced by Persian dynasty Qajar art, 16th-century Mughal miniatures, Indian Pichhwais, and antique pictures. Glass chandeliers hung low from the ceiling illuminated this decked-out maze, where tables were overflowing with food served on silvera custom arrangement for the event.JJ Valaya, AerocityPhoto Courtesy: JJ ValayaFar from the frantic throng, the flagship shop has various design schools. The master couturier created, developed and designed everything in the store, which takes a maximalist but never gaudy approach to design. The store contains a tiny reception area and a jewellery department featuring Aulerth and the new bridge-to-luxury brand, JJV. A winding staircase brings you to the actual treasure, which has equal room for his couture and home lines. The shop is adorned with the designers photographic works, and his home space is an expression of his passion for photography, travel, and all things luxurious. With over three decades of experience in the business, the designer is an institution in his own right, and his designs have a luxurious, old feel to them. A room is dedicated to some of his most expensive and complex bridal lehengas, which are displayed in a museum-style setting and coupled with beautiful dupattas and shawls. He recognises the need for a bridge or pret companies that cater to other minor events, as well as curate travel outfits. JJ Valayas charm is that it is maximalist yet the needlework is ageless.Arjun Kilachand, Mumbai
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Is it really possible to travel back in time? – BBC Sky at Night Magazine
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If time is one of the four dimensions of the Universe, why can we only travel forward in time?
Its true that we live in four dimensions, with three dimensions of space and one of time.
However, the time dimension is different to the three space dimensions because of the way we choose to define it and the way the Universe is constructed.
Nevertheless, one of the remarkable features of physics is that travel into the past does appear to be possible.
A wormhole could make backwards time travel possible. Credit: Mark Garlick / Science Photo Library / Getty Images
According to Einstein, time flows more slowly in stronger gravity.
Imagine two people, one on Earth and the other near a black hole, where time flows more slowly because of the stronger gravity.
We view them on Monday, but by the time the person on Earth reaches Friday, the person near the black hole has only reached Wednesday.
If there was a bridge between the two and Einsteins theory permits one known as a wormhole it would be possible for the person on Earth to travel back from Friday to Wednesday.
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Gene therapy: Donor DNA may protect babies from certain disorders – Medical News Today
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A novel new technique combining DNA from three different people has reportedly been used as a way to prevent the generational transmission of certain rare genetic diseases.
The process, called mitochondrial donation, uses genetic material from a mother and father and a third donor, in an attempt to drastically reduce or eliminate the exchange of mitochondrial diseases such as muscular dystrophy, hearing and vision disorders, epilepsy, heart conditions, learning disabilities, and even potentially neurodegenerative diseases.
Mitochondria are often called the powerhouses of the cell, and in the cases of mitochondrial diseases, they stop being able to power certain functions as well as they would if they were healthy. That includes the most energy-intensive cells, such as nerves and heart muscle cells.
These babies have genomes derived from their biological father and mother just like any other babies but only had their mitochondria replaced with the ones coming from the donor, said Dr. Steven Kim, a researcher in aging and cancer at the Coriell Institute of Medical Research in New Jersey and a medical content advisor at Breakout.
The practitioners did so by transferring the nucleus of the original egg (mother) to a new, unfertilized egg (donor), he explained to Medical News Today. This will theoretically eliminate the mitochondrial disorders but not without limitations since some residual mitochondria can still be present in the egg and later develop problems.
The process has been approved for use in the United Kingdom under the auspices of the countrys Human Fertilization and Embryology Authority (HFEA), which regulates fertility clinics and their operations.
Hopeful parents are eligible for this procedure only if they are at a very high risk of passing a serious mitochondrial disease onto their children, according to the authoritys website.
Mitochondrial diseases can be quite severe, Dr. Shvetha Murthy Zarek, a reproductive endocrinologist and the Medical and Practice IVF Director at Oma Fertility in St. Louis, told Medical News Today. Curative therapies for mitochondrial diseases have proven to be challenging and this technique is promising.
So far, fewer than five babies have been born using this procedure, although 32 have been approved to do so, the HFEA says.
Mitochondrial donation treatment offers families with severe inherited mitochondrial illness the possibility of a healthy child. The HFEA oversees a robust framework which ensures that mitochondrial donation is provided in a safe and ethical manner, they wrote in a statement. These are still early days for mitochondrial donation treatment and the HFEA continues to review clinical and scientific developments.
While the program is an experimental procedure, its success has raised concerns about using genetic techniques to alter babies before birth in ways outside of the scope of rare genetic diseases.
Before its widespread adoption, there will inevitably be some form of ethical scrutiny and debate in the scientific and healthcare communities, and the regulatory authorities will intervene and provide guidance in the near future, Kim said.
But in the case of this particular method, experts say the potential for it to be exploited for other means is low.
This may be seen as a form of genetic engineering, but this form of Artificial Reproductive Technology (ART) does not lead to intentional modifications in a childs physical features, Dr. Karenne Fru, a fertility specialist at Oma Fertility in Atlanta, told Medical News Today. There is limited utility for this form of ART in individuals without mitochondrial disease. As we gather more data on feasibility and long-term effects, it is possible that more couples choose to proceed with this route.
Fru said there was the potential for all genetic mitochondrial disorders to be cured in this fashion since all of a babys mitochondria are passed down through the mother.
Beyond that, she said the ethics were similar to those involved with any in vitro fertilizations involving donors.
There needs to be clear counseling and communication [to kids] about their origins in a supportive manner to avoid any crisis of identity later on, Fru said. Simply put, it took both parents and a generous, healthy donor for them to exist.
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Viewpoint: Grim consequences of Greenpeace’s war on … – Genetic Literacy Project
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A genetically modified rice variety could save the lives of thousands of children. But nowGreenpeacehas prevented the sowing because of alleged health risks. Typical: The eco-activists care neither about science nor about the common good. Your agenda is completely different.
This rice could save the lives of millions of children every year, said the American news magazine Time jubilantly 23 years ago about the successful production of golden rice. Using genetic engineering, biochemists had succeeded in developing the rice variety with increased amounts of a vitamin A precursor. Hundreds of thousands of children go blind every year from vitamin A deficiency, about half of them die. Golden rice could prevent misery.
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But the project is faltering becauseGreenpeaceand other so-called environmental organizations are torpedoing the Golden Rice with lawsuits in court over alleged risks of the genetically modified seeds despite criticism from experts. A study in the journal Environment and Development Economics nine years ago came to the conclusion that delaying the use of golden rice could have cost one and a half million years of life unnecessarily even then.
[Editors note: This article was originally published in German and has been translated and edited for clarity.]
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Predicting Diabetic Kidney Disease with the Use of a Novel Algorithm – Genetic Engineering & Biotechnology News
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Scientists from Sanford Burnham Prebys and the Chinese University of Hong Kong say they have developed a computational approach to predict whether a person with type 2 diabetes will develop kidney disease. Their results, DNA methylation markers for kidney function and progression of diabetic kidney disease, published in Nature Communications, could help doctors prevent or better manage kidney disease in people with type 2 diabetes.
This study provides a glimpse into the powerful future of predictive diagnostics, notes co-senior author Kevin Yip, PhD, a professor and director of bioinformatics at Sanford Burnham Prebys. Our team has demonstrated that by combining clinical data with cutting-edge technology, its possible to develop computational models to help clinicians optimize the treatment of type 2 diabetes to prevent kidney disease.
Diabetes is the leading cause of kidney failure worldwide. In the U.S., 44% of cases of end-stage kidney disease and dialysis are due to diabetes. In Asia, this number is 50%.
There has been significant progress developing treatments for kidney disease in people with diabetes, adds co-senior author Ronald Ma, a professor in the department of medicine and therapeutics at the Chinese University of Hong Kong. However, it can be difficult to assess an individual patients risk for developing kidney disease based on clinical factors alone, so determining who is at greatest risk of developing diabetic kidney disease is an important clinical need.
Epigenetic markers are potential biomarkers for diabetes and related complications. Using a prospective cohort from the Hong Kong Diabetes Register, we perform two independent epigenome-wide association studies to identify methylation markers associated with baseline estimated glomerular filtration rate (eGFR) and subsequent decline in kidney function (eGFR slope), respectively, in 1,271 type 2 diabetes subjects, write the investigators.
Here we show 40 (30 previously unidentified) and eight (all previously unidentified) CpG sites individually reach epigenome-wide significance for baseline eGFR and eGFR slope, respectively. We also developed a multisite analysis method, which selects 64 and 37 CpG sites for baseline eGFR and eGFR slope, respectively. These models are validated in an independent cohort of Native Americans with type 2 diabetes. Our identified CpG sites are near genes enriched for functional roles in kidney diseases, and some show association with renal damage.
This study highlights the potential of methylation markers in risk stratification of kidney disease among type 2 diabetes individuals.
The new algorithm depends on DNA methylation, which occurs when subtle changes accumulate in our DNA. DNA methylation can encode important information about which genes are being turned on and off, and it can be easily measured through blood tests.
Our computational model can use methylation markers from a blood sample to predict both current kidney function and how the kidneys will function years in the future, which means it could be easily implemented alongside current methods for evaluating a patients risk for kidney disease, says Yip.
The researchers developed their model using detailed data from more than 1,200 patients with type 2 diabetes in the Hong Kong Diabetes Register. They also tested their model on a separate group of 326 Native Americans with type 2 diabetes, which helped ensure that their approach could predict kidney disease in different populations.
This study highlights the unique strength of the Hong Kong Diabetes Register and its huge potential to fuel further discoveries to improve our understanding of diabetes and its complications, points out says study co-author Julianna Chan, MD, a professor in the department of medicine and therapeutics at the Chinese University of Hong Kong, who established the Hong Kong Diabetes Register more than two decades ago.
The Hong Kong Diabetes Register is a scientific treasure, adds first author Kelly Yichen Li, PhD, a postdoctoral scientist at Sanford Burnham Prebys. They follow up with patients for many years, which gives us a full picture of how human health can change over decades in people with diabetes.
The researchers are currently working to further refine their model. They are also expanding the application of their approach to look at other questions about human health and diseasesuch as determining why some people with cancer dont respond well to certain treatments.
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Quantum biology on horizon? How futuristic physics theory could … – Study Finds
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Imagine using your cellphone to control the activity of your own cells to treat injuries and disease. It sounds like something from the imagination of an overly optimistic science fiction writer. But this may one day be a possibility through the emerging field of quantum biology.
Over the past few decades, scientists have made incredible progress in understanding and manipulating biological systems at increasingly small scales, from protein folding to genetic engineering. And yet, the extent to which quantum effects influence living systems remains barely understood.
Quantum effects are phenomena that occur between atoms and molecules that cant be explained by classical physics. It has been known for more than a century that the rules of classical mechanics, like Newtons laws of motion, break down at atomic scales. Instead, tiny objects behave according to a different set of laws known as quantum mechanics.
For humans, who can only perceive the macroscopic world, or whats visible to the naked eye, quantum mechanics can seem counterintuitive and somewhat magical. Things you might not expect happen in the quantum world, like electrons tunneling through tiny energy barriers and appearing on the other side unscathed, or being in two different places at the same time in a phenomenon called superposition.
I am trained as a quantum engineer. Research in quantum mechanics is usually geared toward technology. However, and somewhat surprisingly, there is increasing evidence that nature an engineer with billions of years of practice has learned how to use quantum mechanics to function optimally. If this is indeed true, it means that our understanding of biology is radically incomplete. It also means that we could possibly control physiological processes by using the quantum properties of biological matter.
Researchers can manipulate quantum phenomena to build better technology. In fact, you already live in a quantum-powered world: from laser pointers to GPS, magnetic resonance imaging and the transistors in your computer all these technologies rely on quantum effects.
In general, quantum effects only manifest at very small length and mass scales, or when temperatures approach absolute zero. This is because quantum objects like atoms and molecules lose their quantumness when they uncontrollably interact with each other and their environment. In other words, a macroscopic collection of quantum objects is better described by the laws of classical mechanics. Everything that starts quantum dies classical. For example, an electron can be manipulated to be in two places at the same time, but it will end up in only one place after a short while exactly what would be expected classically.
In a complicated, noisy biological system, it is thus expected that most quantum effects will rapidly disappear, washed out in what the physicist Erwin Schrdinger called the warm, wet environment of the cell. To most physicists, the fact that the living world operates at elevated temperatures and in complex environments implies that biology can be adequately and fully described by classical physics: no funky barrier crossing, no being in multiple locations simultaneously.
Chemists, however, have for a long time begged to differ. Research on basic chemical reactions at room temperature unambiguously shows that processes occurring within biomolecules like proteins and genetic material are the result of quantum effects. Importantly, such nanoscopic, short-lived quantum effects are consistent with driving some macroscopic physiological processes that biologists have measured in living cells and organisms. Research suggests that quantum effects influence biological functions, including regulating enzyme activity, sensing magnetic fields, cell metabolism and electron transport in biomolecules.
The tantalizing possibility that subtle quantum effects can tweak biological processes presents both an exciting frontier and a challenge to scientists. Studying quantum mechanical effects in biology requires tools that can measure the short time scales, small length scales and subtle differences in quantum states that give rise to physiological changes all integrated within a traditional wet lab environment.
In my work, I build instruments to study and control the quantum properties of small things like electrons. In the same way that electrons have mass and charge, they also have a quantum property called spin. Spin defines how the electrons interact with a magnetic field, in the same way that charge defines how electrons interact with an electric field. The quantum experiments I have been building since graduate school, and now in my own lab, aim to apply tailored magnetic fields to change the spins of particular electrons.
Research has demonstrated that many physiological processes are influenced by weak magnetic fields. These processes include stem cell development and maturation, cell proliferation rates, genetic material repair and countless others. These physiological responses to magnetic fields are consistent with chemical reactions that depend on the spin of particular electrons within molecules. Applying a weak magnetic field to change electron spins can thus effectively control a chemical reactions final products, with important physiological consequences.
Currently, a lack of understanding of how such processes work at the nanoscale level prevents researchers from determining exactly what strength and frequency of magnetic fields cause specific chemical reactions in cells. Current cellphone, wearable and miniaturization technologies are already sufficient to produce tailored, weak magnetic fields that change physiology, both for good and for bad. The missing piece of the puzzle is, hence, a deterministic codebook of how to map quantum causes to physiological outcomes.
In the future, fine-tuning natures quantum properties could enable researchers to develop therapeutic devices that are noninvasive, remotely controlled and accessible with a mobile phone. Electromagnetic treatments could potentially be used to prevent and treat disease, such as brain tumors, as well as in biomanufacturing, such as increasing lab-grown meat production.
Quantum biology is one of the most interdisciplinary fields to ever emerge. How do you build community and train scientists to work in this area?
Since the pandemic, my lab at the University of California, Los Angeles and the University of Surreys Quantum Biology Doctoral Training Centre have organized Big Quantum Biology meetings to provide an informal weekly forum for researchers to meet and share their expertise in fields like mainstream quantum physics, biophysics, medicine, chemistry and biology.
Research with potentially transformative implications for biology, medicine and the physical sciences will require working within an equally transformative model of collaboration. Working in one unified lab would allow scientists from disciplines that take very different approaches to research to conduct experiments that meet the breadth of quantum biology from the quantum to the molecular, the cellular and the organismal.
The existence of quantum biology as a discipline implies that traditional understanding of life processes is incomplete. Further research will lead to new insights into the age-old question of what life is, how it can be controlled and how to learn with nature to build better quantum technologies.
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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Quantum biology on horizon? How futuristic physics theory could ... - Study Finds
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