Daily Archives: October 8, 2022

Growth in Cell and Gene Therapy Market – Pharmaceutical Technology Magazine

Posted: October 8, 2022 at 4:03 pm

Biopharma focuses on streamlining biomanufacturing and supply chain issues to drive uptake of cell and gene therapies.

Cell and gene therapies (CGTs) offer significant advances in patient care by helping to treat or potentially cure a range of conditions that have been untouched by small molecule and biologic agents. Over the past two decades, more than 20 CGTs have been approved by FDA in the United States and many of these one-time treatments cost between US$375,00 and US$2 million a shot (1). Given the high financial outlay and patient expectations of these life-saving therapies, it is essential that manufacturers provide integrated services across the whole of the supply chain to ensure efficient biomanufacturing processes and seamless logistics to reduce barriers to uptake.

The following looks at the who, what, when, and why of biomanufacturing and logistics in CGTs in the bio/pharmaceutical industry in more detail.

According to market research, the global gene therapy market will reach US$9.0 billion by 2027 due to favorable reimbursement policies and guidelines, product approvals and fast-track designations, growing demand for chimeric antigen receptor (CAR) T cell-based gene therapies, and improvements in RNA, DNA, and oncolytic viral vectors (1).

In 2020, CGT manufacturers attracted approximately US$2.3 billion in investment funding (1). Key players in the CGT market include Amgen, Bristol-Myers Squibb Company, Dendreon, Gilead Sciences, Novartis, Organogenesis, Roche (Spark Therapeutics), Smith Nephew, and Vericel. In recent years, growth in the CGT market has fueled some high-profile mergers and acquisitions including bluebird bio/BioMarin, Celgene/Juno Therapeutics, Gilead Sciences/Kite, Novartis/AveXis and the CDMO CELLforCURE, Roche/Spark Therapeutics, and Smith & Nephew/Osiris Therapeutics.

Many bio/pharma companies are re-considering their commercialization strategies and have re-invested in R&D to standardize vector productions and purification, implement forward engineering techniques in cell therapies, and improve cryopreservation of cellular samples as well as exploring the development of off-the-shelf allogeneic cell solutions (2).

The successful development of CGTs has highlighted major bottlenecks in the manufacturing facilities, and at times, a shortage of raw materials (3). Pharma companies are now taking a close look at their internal capabilities and either investing in their own manufacturing facilities or outsourcing to contract development and manufacturing organizations (CDMOs) or contract manufacturing organizations (CMOs) to expand their manufacturing abilities (4). Recently, several CDMOsSamsung Biologics, Fujifilm Diosynth, Boehringer Ingelheim, and Lonzahave all expanded their biomanufacturing facilities to meet demand (5).

A major challenge for CGT manufacturers is the seamless delivery of advanced therapies. There is no room for error. If manufacturers cannot deliver the CGT therapy to the patient with ease, the efficacy of the product becomes obsolete. Many of these therapies are not off-the-shelf solutions and therefore require timely delivery and must be maintained at precise temperatures to remain viable. Thus, manufacturers must not only conform to regulations, but they must also put in place logistical processes and contingency plans to optimize tracking, packaging, cold storage, and transportation through the products journey. Time is of the essence, and several manufacturers have failed to meet patient demands, which have significant impacts on the applicability of these agents.

Several CAR T-cell therapies have now been approved; however, research indicates that a fifth of cancer patients who are eligible for CAR-T therapies pass away while waiting for a manufacturing slot (6). Initially, the manufacture of many of these autologous products took around a month, but certain agents can now be produced in fewer than two weeks (7). Companies are exploring new ways to reduce vein-to-vein time (collection and reinfusion) through the development of more advanced gene-transfer tools with CARs (such as transposon, CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) among others, and the use of centralized organization with standardized apheresis centers (5). Others are exploring the use of the of allogeneic stem cells including Regen Biopharma, Escape Therapeutics, Lonza, Pluristem Therapeutics, and ViaCord (7).

Several gene therapies have also been approved, mainly in the treatment of rare disease (8). Many companies are evaluating novel gene therapy vectors to increase levels of gene expression/protein productions, reduce immunogenicity and improve durability including Astellas Gene Therapies, Bayer, ArrowHead Pharmaceuticals, Bayer, Bluebird Bio, Intellia Therapeutics, Kystal Biotech, MeiraGTx, Regenxbio, Roche, Rocket Pharmaceuticals, Sangamo Therapeutics, Vertex Pharmaceuticals, Verve Therapeutics, and Voyager Therapeutics (8).

While many biopharma companies have established their own in-house CGT good manufacturing practice (GMP) operation capabilities, others are looking to decentralize manufacturing and improve distribution by relying on external contracts with CDMOs and CMOs such as CELLforCURE, CCRM, Cell Therapies Pty Ltd (CTPL), Cellular Therapeutics Ltd (CTL), Eufets GmbH, Gravitas Biomanufacturing, Hitachi Chemical Advances Therapeutic Solutions, Lonza, MasTHerCell, MEDINET Co., Takara Bio, and XuXi PharmaTech (6, 9, 10).

The top 50 gene therapy start-up companies have attracted more than $11.6 billion in funds in recent years, with the top 10 companies generating US$5.3 billion in series A to D funding rounds (10). US-based Sana Biotechnology leads the field garnering US$700 million to develop scalable manufacturing for genetically engineered cells and its pipeline program, which include CAR-T cell-based therapies in oncology and CNS (Central Nervous System) disorders (11). In second place, Editas Medicine attracted $656.6 million to develop CRISPR nuclease gene editing technologies to develop gene therapies for rare disorders (12).

Overall, CGTs have attracted the pharma industrys attention as they provide an alternative route to target diseases that are poorly served by pharmaceutical and/or medical interventions, such as rare and orphan diseases. Private investors continue to pour money into this sector because a single shot has the potential to bring long-lasting clinical benefits to patients (13). In addition, regulators have approved several products and put in place fast track designation to speed up patient access to these life-saving medicines. Furthermore, healthcare providers have established reimbursement policies and manufacturers have negotiated value- and outcome-based contracts to reduce barriers to access to these premium priced products

On the downside, the manufacture of CGTs is labor intensive and expensive with manufacturing accounting for approximately 25% of operating expenses, plus there is still significant variation in the amount of product produced. On the medical side, many patients may not be suitable candidates for CGTs or not produce durable response due to pre-exposure to the viral vector, poor gene expression, and/or the development of immunogenicity due to pre-exposure to viral vectors. Those that can receive these therapies may suffer infusion site reactions, and unique adverse events such as cytokine release syndrome and neurological problems both of which can be fatal if not treated promptly (14).

Despite the considerable advances that have been made in the CGT field to date, there is still much work needed to enhance the durability of responses, increase biomanufacturing efficiencies and consistency and to implement a seamless supply chain that can ensure these agents are accessible, cost-effective, and a sustainable option to those in need.

Cleo Bern Hartley is a pharma consultant, former pharma analyst, and research scientist.

Pharmaceutical TechnologyVolume 46, Number 10October 2022Pages: 54-55

When referring to this article, please cite it as C.B. Hartley, "Growth in Cell and Gene Therapy Market," Pharmaceutical Technology 46 (10) 5455 (2022).

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Gene Editing Service Market 2022 : Top Players to Reflect Impressive Growth Rate till 2029: Caribou Biosciences, CRISPR Therapeutics, Merck KGaA,…

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The Gene Editing Service Market research report forecast 2022 -2029 provides in-depth information on market trends, market capacity, industry size, growth factors, share, innovations, competitive environment, business problems, and more. This reports historical data confirms demand growth on a global, national, and regional scale. The research of the Gene Editing Service also aids in the understanding of industry prospects and growth chances. This report leverages advanced tools such as SWOT analysis and Porters Five Forces analysis to accurately estimate market and revenue growth. The report also provides an extensive analysis of the impact of the COVID-19 pandemic and how it contributed to market progress.

Market research reports from WMR include a competitive landscape, in-depth vendor selection methodology, and analysis based on qualitative and quantitative research to properly Gene Editing Service Market growth. In this Research Report, by analyzing key aspects such as profit, pricing, competition, and promotions, as well as examining, synthesizing, and summarising data from many sources, the analyst produces a comprehensive picture of the Gene Editing Service market. It shows a variety of market elements by identifying the top industry influencers. The market study further also draws attention to crucial industry factors such as global clients, potential customers, and sellers, which instigates positive company growth. In order to gauge the turning point of the businesses, significant market key players are also enlisted in order to deliver readers an in-depth analysis of industry strategies.

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Caribou Biosciences CRISPR Therapeutics Merck KGaA Editas Medicine Thermo Fisher Scientific Horizon Discovery Genscript Biotech GeneCopoeia Integrated DNA Technologies Eurofins Genomics DNA 2.0 (ATUM) BBI Life Sciences Genewiz Gene Oracle SBS Genetech Bio Basic

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Global markets are presented by Gene Editing Service type, along with growthforecasts. Estimates of production and valueare based on the price in the supply chain at which the Gene Editing Service are procured by the manufacturers.

This report has studied every segment and provided the market size using historical data. They have also talked about the growth opportunities that the segment may pose in the future. This study bestows production and revenue data by type, and during the historical period and forecast period.

Ex-Vivo In-Vivo

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This report has provided themarket size (production and revenue data) by application, during the historical period and forecast period.

This report also outlines the market trends of each segment and consumer behaviors impacting the Gene Editing Service market and what implications these may have on the industrys future. This report can help to understand the relevant market and consumer trends that are driving the Gene Editing Service market.

Commercial Academic Research

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The Gene Editing Service Market engineering process uses a top-down and bottom-up approach and several data triangulation methods to evaluate and validate the size of the entire market and other dependent sub-markets listed in this research report. The major players in the market were identified through the second survey and the market rankings were determined through the first and second surveys.

To analyze actual Gene Editing Service market sales and their breakdowns, primary and secondary approaches were used. The Gene Editing Service assessment comprised extensive primary searches, such as surveys, expert opinions, profiles, and secondary ratings to business magazines, industry directories, paid venues, and others. In addition, the industry research examines data acquired from a range of sector analysts and significant market participants along the industrys value chain to provide a succinct quantitative and qualitative analysis.

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North America (U.S., Canada, Mexico) Europe (U.K., Italy, Germany, France, Rest of the EU) Asia-Pacific (India, Japan, China, South Korea, Australia, Rest of APAC) Latin America (Chile, Brazil, Argentina, Rest of Latin America) Africa and the Middle East (Saudi Arabia, U.A.E., South Africa, Rest of MEA)

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This research contains detailed information on the factors that are projected to impact Gene Editing Service market growth and share in the future.

The report examines the present situation of the Gene Editing Service market as well as future prospects for a variety of geographic locations.

It can be used as a SWOT and competitive landscape study when combined with Porters Five Forces analysis.

It gives an in-depth examination of the industry, highlighting its growth rates and expansion potential.

The research contains a wealth of information, including Gene Editing Service market dynamics and opportunities for the forecast period.

Quantitative, qualitative, value (USD Million), and volume (Units Million) data are among the segments and sub-segments.

Data on demand and supply forces, as well as their impact on the Gene Editing Service market, may be found at the regional, sub-regional, and country levels.

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Mr. ShahWorldwide Market Reports,Tel: U.S. +1-415-871-0703U.K. +44-203-289-4040Japan +81-50-5539-1737Email: [emailprotected]Website:https://www.worldwidemarketreports.com/

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Tip Sheet: $78 million to support new precision oncology institute, update on experimental gene therapy for herpes and the launch of Fred Hutch’s new…

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SEATTLE Oct. 4, 2022 Below are summaries of recent Fred Hutchinson Cancer Center research findings and other news.

Join us for our next virtual science event focused on precision oncology. The discussion will be 10 a.m. - 11 p.m. PT on Wednesday, Oct. 12 and will feature Drs. Thomas Lynch Jr., Christina Baik, Sujata Jana, Jeff Leek and Colin Pritchard. Please RSVP HERE by Monday, Oct. 10.

And if youre looking for sources for Octobers Breast Cancer Awareness Month, please see our breast cancer page for a list of projects, experts and the latest breast cancer news.

Fred Hutch organizational news

Fred Hutch begins rollout of new brandFred Hutchinson Cancer Research Center and Seattle Cancer Care Alliance formally merged in April 2022 to officially become Fred Hutchinson Cancer Center. In October the organizations new brand was officially launched, with updates to websites, social media channels and banners as well as updated signs around the South Lake Union campus. Patients and providers will see temporary signage and other updates at Fred Hutch clinical care sites around the Seattle region in the coming months.Media contact: Kat Wynn, kwynn@fredhutch.org

Precision oncology

Transformative $78M gift to establish new precision oncology instituteStuart and Molly Sloan have pledged $78 million to support Fred Hutch. The gift will further advance Fred Hutchs work in precision oncology, which integrates fundamental biology, technology, immunology, data science and clinical experience into strategies to prevent, detect and treat cancer.Media contact: Kat Wynn, kwynn@fredhutch.org

Infectious disease

Researchers refine experimental gene therapy for herpesTwo years after scientists showed that an experimental gene therapy for herpes which affects billions of people around the world can knock out most latent infection in mice, new tests reveal that it also suppresses the amount of transmissible virus shed by the treated animals. In a paper posted on bioRxiv, Fred Hutch virologists Drs. Keith Jerome and Martine Aubert report the treatment dramatically reduced or even eliminated viral shedding in treated mice compared to controls.Media contact: Molly McElroy, mwmcelro@fredhutch.org

Health equity

Spokane Regional Health District: Gaps in cancer care experienced in SpokaneFor their podcast Cancer Health Equity Now, members of Fred Hutchs Office of Community Outreach and Engagement in Spokane spoke with Spokane Regional Health District Health Officer Dr. Frank Velazquez. They discussed gaps in access to cancer care in Spokane, collaboration efforts by local organizations, and the feasibility of a sustainable Mobile Mammogram Program locally.Media contact: Kat Wynn, kwynn@fredhutch.org

On Twitter

Follow Dr. Aakansha Singhvi (@SinghviLabGlia) as the Singhvi lab works towards understanding how glia-neurons interact with the nervous system and the key role worms play.

Virus evolution expert Dr. Jesse Bloom (@jbloom_lab) recently shared a study on the evolution of antibody immunity following Omicron BA. He said, Although response to Omicron dominated by preexisting B-cells, antibodies from these cells better at 6 months than 1 month.

Science spotlightScience Spotlight is a monthly installment of articles written by postdoctoral fellows at Fred Hutch that summarize new research papers from Hutch scientists. If youre interested in learning more or covering these topics, contact: media@fredhutch.org

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Fred Hutchinson Cancer Center unites comprehensive care and advanced research to provide the latest cancer treatment options and accelerate discoveries that prevent, treat and defeat cancer and infectious diseases worldwide.

Based in Seattle, Fred Hutch is an independent, nonprofit organization and the only National Cancer Institute-designated cancer center in Washington. We have earned a global reputation for our track record of discoveries in cancer, infectious disease and basic research, including important advances in bone marrow transplantation, HIV/AIDS prevention, immunotherapy and COVID-19 vaccines. Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy and related services and has network affiliations with hospitals in four states. Fred Hutch also serves as UW Medicines cancer program.

Please note that our organization was renamed Fred Hutchinson Cancer Center in April 2022, following the merger of long-time partners, Fred Hutchinson Cancer Research Center and Seattle Cancer Care Alliance.

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On the short life and sudden death of Soviet atheism – OnlySky

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Overview

To understand why the Communist Party abandoned atheism, we must go back to the beginning of the Soviet project, charting the ways in which the meaning of religion and atheism changed over time.

On April 29, 1988, at the height of perestroika, General Secretary of the Soviet Communist Party Mikhail Gorbachev made the unanticipated decision to meet with Patriarch Pimen and the Synod of Bishops of the Russian Orthodox Church. This was the first official meeting between the leader of the Soviet Communist Party and the hierarchs of the Orthodox Church since 1943 when Joseph Stalin summoned three Orthodox metropolitans to the Kremlin in the middle of the night to inform them that after more than two decades of repression, the Orthodox Church could return to Soviet life with the benediction of the state.

The direct impetus for Gorbachevs meeting with the patriarch was the approaching millennium of the Christianization of Rus an event commemorating Grand Prince Vladimirs adoption of Christianity in 988 as the official religion of Kyivan Rus, which gathered his diverse lands and peoples into a unified state.

Gorbachevs motives for meeting with the patriarch were not unlike Stalinswhich is to say, they were political. Just as Stalin had broken with two decades of antireligious policy in order to mobilize patriotism at home and appeal to allies abroad in the midst of a catastrophic war, Gorbachev was attempting to harness Orthodoxys moral capital at home and court political favor abroad in order to regain control over perestroikawhich by early 1988 was not only losing popular support but also being challenged from within the Soviet political establishment by Communist Party conservatives as well as nationalists across the Soviet Unions titular republics, including Russia itself.

During the meeting with the Patriarch, Gorbachev noted that, whereas before it had been relegated to a strictly religious event, the Millennium would now be commemorated not only in a religious but also a sociopolitical tone, since it was a significant milestone in the centuries-long path of the development of the fatherlands history, culture, and Russian statehood. Gorbachev also called on the church to play a role in the moral regeneration of Soviet society, where universal norms and customs can help our common cause.

Gorbachev acknowledged the deep worldview differences between the Soviet Communist Party and the Russian Orthodox Church, but emphasized that religious believers were nevertheless Soviet people, working people, patriots, and, as such, entitled to all the rights of Soviet citizenship without restrictionsincluding the full right to express their convictions with dignity.

Finally, Gorbachev offered the church unprecedented concessions: to return religious property that had been nationalized by the Bolsheviks following the Revolution; to allow religious instruction and charity work; to eliminate restrictions on the publication of religious literature, including the Bible; and to revise the draconian laws that had governed religious life in the USSR for decades.

Yet what turned out to be the most consequential concession was the new prohibition on the Soviet states political and material support of atheist worka provision that effectively ended the relationship between Communism and atheism in the Soviet Union.

Gorbachevs meeting with the Orthodox patriarch transformed the Russian Orthodox millennium from a narrowly religious eventan event that had been deliberately portrayed by the media as marginal to Soviet lifeinto a national celebration sanctioned by the Communist establishment.

So why did the Communist Party abandon atheism?

To answer this question, we have to go back to the beginning of the Soviet project to look at the meaning of religion and atheism to Soviet Communism, andmore importantlyto the way in which this meaning changed over time.

The Bolsheviks imagined Communism as a world without religion. The Soviet experiment was the first attempt to turn this vision into reality. When they seized power in October 1917, the Bolsheviks promised to liberate people from the old world to overcome exploitation with justice, conflict with harmony, superstition with reason, and religion with atheism. They rejected all previous sources of authority, replacing the autocratic state with Soviet power, religious morality with class morality, and backwardness and superstition with progress and enlightenment. They renounced traditional religious institutions, theologies, and ways of life, offering in their place the Communist Party and Marxism-Leninisma party that claimed a monopoly on power and truth, and an ideology that promised to give new meaning to collective and individual life.

Atheism, at its core, rejects the idea that transcendent or supernatural power can act upon and shape the material world. In the Soviet context, atheism underpinned Communisms most radical and utopian premise: the promise that humanity could master the world, and that injustice and evil could be overcome in this life rather than the next. But Soviet atheism was also about power, a tool for undermining competing sources of political, ideological, and spiritual authority political institutions that were not the Communist Party, ideologies that were not Marxism- Leninism, communities that were not the Soviet people, and ways of life that were not the Soviet way of life. In contesting competing claims to truth and authority, Soviet Communism assumed the burden of providing its own answers to lifes questions and solutions to lifes problems. In this way, atheism became the battleground on which Soviet Communism engaged with the existential concerns at the heart of human existence: the meaning of life and death.

Soviet atheism underpinned Communisms most radical and utopian premise: the promise that humanity could master the world, and that injustice and evil could be overcome in this life rather than the next.

As faithful Marxists-Leninists, the Bolsheviks did not anticipate religion to be a serious obstacle to their project of revolutionary transformation. They understood, of course, that seizing political power would not immediately transform society, but they had faith in the Marxist model of historical development according to which religion would inevitably wither away. What became clear after the October Revolution was that religion was not going to die a natural death. The unfolding of history would require the active involvement of the Bolshevik Party. To understand how the party approached this contest over sacred authority, we can look at three sets of oppositions: the political opposition between the partys commitment to ideological purity and the states pursuit of effective governance; the ideological opposition between religion, superstition, and backwardness and science, reason, and progress; and the spiritual opposition between indifference and conviction.

For the Bolsheviks, religion consisted of three elements: the political, grounded in religious institutions; the ideological, embodied in a (false) religious dogma and worldview grounded in the supernatural; and the spiritual, encompassed in the values, practices, and customs that made up everyday life. The partys engagements with religion reflected this understanding. To address religion as a political problem, the party deployed militant anticlericalism, using administrative regulation and repression to circumscribe the autonomy of religious institutions, marginalize religion in public life, and undermine its political power. To address religion as an ideological problem, the party relied on propaganda, education, and enlightenment to inculcate a scientific materialist worldview. Finally, to address religion as a spiritual problem, the party used cultural tools to transform traditional ways of life into the new Communist way of life. For the Bolsheviks, overcoming religion was a process: religious institutions had to be neutralized before religious beliefs could be eradicated, and worldviews had to be freed from religious beliefs before spiritual life could be transformed.

The first step, then, was to solve religion as a political problem.

Under Lenin and Stalin, from the revolution in 1917 until Stalins death in 1953, the Bolsheviks used administrative regulation, extralegal repression and terror, and militant atheist propaganda in their engagements with religion. Even as Bolshevik ideology proclaimed it was building a new world, remaking society, and transforming human nature, in practice the party devoted little attention to atheism. This was because religion remained above all a political problem: a tool that could be used by the enemy to undermine the revolution.

In the first decades of Soviet power, the partys efforts were focused on breaking religion, and the Orthodox Church in particular, by attacking religious spaces, clergy, and especially fervent believers. For the masses, the party approached religion as a form of backwardness that could be overcome through enlightenment. To this end, churches, synagogues, and mosques were often closed, destroyed, or turned into secular spaces such as museums (including antireligious museums), planetariums, clubhouses, swimming pools, and even storage facilities.

But ultimately, for Lenin and Stalin, religion mattered above all because it constituted a political threat. And by the end of the 1930swith the political power of the Orthodox Church nearly destroyedthe party believed that threat was neutralized. From this point, the continued existence of religion in the Soviet Union would be on the states terms. Ironically, Stalins last decade in power (1943 to 1953) was a period of relative stability, even growth, for the Russian Orthodox Church. After radical repression of religion, the state was allowing the opening of religious spaces, so the number of Russian Orthodox churches increased from around 1,000 in 1939 to around 14,000 in 1953. Atheism, on the other hand, lost much of its political support and became practically invisible in public life until the arrival of Stalins successor, Nikita Khrushchev.

So why does atheism return under Khrushchev? And how does atheism transform during the Khrushchev era?

Following Stalins death, Khrushchev sought to place the Soviet project on new foundations with his project of building Communism. Religion was now transformed from a political enemy into an alien ideology inside Soviet borders, and therefore a stain on Soviet modernity. However, since religion remained a fact of Soviet life, and since Communism and religion were considered fundamentally incompatible, atheism was revived after an almost twenty-year hiatus. In fact, under Khrushchev the party mobilized the most extensive antireligious campaign in Soviet history, closing nearly half the countrys religious spaces, instituting harsh new laws limiting religious autonomy, and investing unprecedented resources in atheist propaganda. When atheism returned under Khrushchev, therefore, it was no longer cast as a political problem, but an ideological one. Believers were not to be cast out of the body politic, as in the early Soviet period, but rescued from their own backwardness through science and enlightenment.

The militant atheism of the early Soviet period was transformed into scientific atheism. The euphoria around the Soviet space program was harnessed to spread the message that the cosmonauts had not seen God on their space journeys, and planetariums became sites of personal transformation where Soviet people could shed their ignorance and, in the words of a propaganda poster from the time, Step across the ominous shadow [of religion] and join Soviet society on the other side, in the joyful bustle of the day! Rather than go to church, believers were encouraged to head to the planetarium or the local house of culture to listen to lectures meant to facilitate their enlightenment.

Yet when atheists attempted to fight faith with fact, they often encountered people who were untroubled by the contradictions that atheist propaganda so ardently unmasked, and instead reconciled scientific and religious cosmologies in unexpected ways. That science, technology, and enlightenmentand even the miracles of cosmic conquestsfailed to convert the masses to atheism forced atheists to recognize that chasing the gods out of the heavens was not enough, and that in order to reach the Soviet soul, scientific atheism had to also fill the empty space with its own positive meaning. Atheists also realized that they would have to engage not just the rational but also the spiritual.

The failure of religion to die out, even after the partys best efforts to hurry the process along with antireligious campaigns, forced atheists to confront the complex reality of lived religiosity, and to fundamentally reconsider both the definition of religion and approaches to atheist work. After failing to overcome religion through ideological approaches, the party began to see religion as above all a spiritual problem. More specifically, the party became aware of a spiritual emptinessa mass sentiment of indifferencespreading in Soviet society. This diagnosis of indifference extended to both religious and atheist worldviews, its symptoms manifesting as political apathy, ideological hypocrisy, philistine individualism, and spiritual consumerism. And as the Soviet leadership noted with alarm, indifference was spreading through Soviet society, and especially among Soviet youth. Indeed, by the 1970s, indifference seemed more pervasive than any commitments Soviet citizens had to religion or atheism, and as a phenomenon seemed more worrisome than the continued existence of religion.

As the ideological apparatus tried to understand why indifference was becoming a mass phenomenon, the stakes of the inability to produce atheist conviction came into focus: if they failed to fill the sacred space at the center of the Soviet project, it would be filled by alien ideologies and commitmentssince, as the proverb goes, a sacred space is never empty. And this anxiety about the consequences of Soviet societys ideological indifference returned religion back into the sphere of politics.

Gorbachevs dramatic reversal in the Soviet position on religion on the eve of the Orthodox millennium was politically consequential, perhaps even fateful. For Soviet power, it ultimately undermined the ideological foundations of Soviet Communism and the partys claims to legitimacy. Indeed, the return of religion to politics and public life in 1988 can be seen as the entry of the Soviet Communist project into its final chapter: dissolution.

From the beginning, religion was a destabilizing force within Soviet Communism. As ideologically mobilized party cadres and citizen activists repeatedly reminded the party, religion was the only ideological alternative to Marxism-Leninism legally permitted to exist within the closed world of Soviet Communism. Until the 1970s, however, religion could still be folded into the ideological narrative since it could still be construed as dying out. The return of religion first to Soviet culture, with the intelligentsias spiritual turn under Brezhnev; then to the mass media, with the appearance of positive portrayals of religion on television and in the press under Gorbachev; and finally to public life, with the officially sanctioned celebration of the Russian Orthodox Millennium in 1988 disrupted the internal logic of the Soviet Communism.

The Soviet Communist Partys abandonment of atheism and sanctioning of religion destabilized the coherence of Marxist-Leninist ideology, which in turn undermined the legitimacy of the party, which had always defined itself against the political, ideological, and spiritual claims of religion, and viewed the decline of religion as a measure of progress toward Communism. Soviet atheism therefore did not die; it was abandoned by a political project that came to see it as useless to the broader goal of consolidating political, ideological, and spiritual authority. Soviet atheism was abandoned in the divorce of party and state, becoming utopias orphan.

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Darwin and the New Atheists – Discovery Institute

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Photo credit: Fronteiras do Pensamento [CC BY-SA 2.0], via Wikimedia Commons.

The somewhat superannuated 19th-century conflict model once used to define embattled evolutionary and religious claims to truth status has in our own time made an unheralded comeback in the writings of a diverse group of social commentators widely referred to as the new atheists.1For much of the 20th century that older, conflict model, represented by the writings of the late Victorian era Andrew Dixon White2and others, was modified in light of intellectual developments which came preponderantly to view science and religion as separate domains, each with its own sharply defined epistemological boundary.3In the last few decades, however, some ideologically engaged scientific activists and commentators with erstwhile Oxford biologist Richard Dawkins at their head have seized the opportunity to weaponize Darwinism to push an atheist agenda against the backdrop of what they see as a dangerous uptick in global religious sentiment. In this and two subsequent posts I wish to explore how justified the groups appropriation of Darwinian ideas is.

First of all, there is surely some historical irony in the attempt to enlist Charles Darwin posthumously in defense of the atheist cause when he persistently resisted efforts to drag his name into a conflict which he felt to be none of his choosing. In his lifetime Darwin pointedly opposed efforts to instrumentalize his ideas in the cause of militant atheism, most signally when he declined to give Britains first openly atheist Member of Parliament, Charles Bradlaugh, his seal of approval. From that polite but firm refusal it may be inferred that Darwin, had he lived, would have given latter-day Bradlaughs similarly short shrift. As the later course of his scientific career demonstrated, Darwins preferred way was the quietist one of avoiding conflict and controversy, made manifest in his dedication of the latter decades of his life to the uncontroversial subject of barnacles. Yet Darwins temperamental desire for an uncontroversial life tells only a part of the story. The more substantive reason for his disinclination to join the contemporary ranks of Bradlaugh, Annie Besant, and other materialist proselytizers was that with older age came the grace to disavow any implicit claims to omniscience. At that stage of his life he felt duty-bound to candidly acknowledge that he was notcompletelyconvinced of his own theory.

Darwin had always believed that his grandfathers writings on evolution had been excessively speculative. And in truth there was very little of substance that Erasmus was able to offer that distinguished his ideas from the first human being to speculate on evolution since written records began, namely, the Greek Anaximander in the sixth century BC he having been a natural philosopher who commands respect even in our own day.4Reading ErasmussTemple of NatureorZoonomiaone still encounters the same underlying narrative of organic life emerging from primordial slime and evolving and diversifying from an organic ground zero as that advanced by Anaximander and his follower Anaximenes.5And like the Greeks, Erasmus advanced no empirical evidence that would allow his claims to be tested. Not surprisingly then, evolution was widely regarded before 1859 as the minority preoccupation of a group of eccentrics rather than as a key to unlocking the mysteries of human existence.

Fast forward to a century later and we find that Charles Darwin was acutely aware of the checks and balances set up by modern science in order to establish any given theory as a demonstrablefact. Realizing that his grandfathers ideas did not meet modern standards of proof, he looked for a sounder causal foundation for the Erasmian contribution to evolution. This he was to find in the theory of natural selection which he derived and developed from the writings of Thomas Malthus. It was via Malthus that Darwin thought to have discovered a mechanism orvera causato underpin his grandfathers ideas. In time, however, he began to harbor doubts about what he had first confidently hoped would be his game-changer with the capacity to bring evolutionary thought into a new era of acceptance and public prestige.

In later decades of his life, however, Charles began to doubt whether his postulated theory of natural selection would have been enough on its own to effect all the extraordinary transmutations evidenced by the worlds profusion of widely different species. This thought even led him to flirt with Lamarckian ideas of evolution which he had previously scorned.6

The upshot of the authors second thoughts was that the sixth edition of theOriginwas very different from the 1859 version and in some cases quite inconsistent with the first iteration of his ideas.7Most strikingly, there arose within him a growing tension concerning his public postulation of an evolutionary theory dependent on natural selection and his claim in older age to be a Theist (Darwins own capitalization).8It therefore appears that the more valid historical parallel for the new atheists is not Charles himself but Charless grandfather. The preoccupation of the Darwin family with evolutionary speculation was something which grew by stages9and it is at a much earlier stage that a less ambiguous correlation emerges between evolutionary thought and atheism.

What links Erasmus Darwin with the modern proponents of atheism is that the grandfather grew up against the background of that crypto-atheistical doctrine of deism according to which God had shrunk to the status of adeus absconditusor to use the deprecatory contemporary cognomen absentee landlord. Given such a backdrop of non-belief the question arises: Which came first in Erasmuss thinking: the chicken or the egg? By which I mean: Was his desire to ponder possibilities of a purely material and naturalistic process of creation and evolution triggered by a deist conviction that, even if God had ever existed, he had now long since disappeared from human ken and was in that sense functionally irrelevant to human affairs? In other words, was his whole theory of evolution triggered by what is now called materialist confirmation bias (as one strongly suspects is the case of the new atheists)? For it is clear that if one has been convinced (or has convinced oneself) that there neither is nor can ever be evidence of divine direction in human affairs, then one is forced to speculate onsomewholly material alternative, however illogical, impracticable, and physiologically improbable it might appear.

Next, Erasmus Darwin and Credible Denial.

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Darwin and the New Atheists - Discovery Institute

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Contompasis convicted in 2021 stabbing of two Proud Boys – Times Union

Posted: at 4:00 pm

ALBANY A jury quickly convicted Alexander Contompasis of first-degree assault and all other charges Friday for stabbing two members of the far-right Proud Boys outside the state Capitol during a rally on Jan. 6, 2021.

Contompasis, who has been identified on Facebook as an independent journalist and poet, faces the possibility of 40 years in prison after being convicted of the stabbing the menat a "Stop the Steal" rally held in East Capitol Park. It was held the same day that other supporters of former President Donald J. Trump, including Proud Boys members, stormed the U.S. Capitol in Washington, D.C., as Congress prepared to certify President Joseph Biden's victory.

After deliberating roughly three hours and re-watching a video of the incident multiple times in slow motion the jury convicted the 39-year-old Albany manof first-degree assault, which carries up to 25 years in prison;attempted assault in the first degree, which carries up to 15 years in prison;second-degree assault and felony possession of a weapon following a week-long trial before acting Supreme Court Justice Roger McDonough.

Assistant District Attorneys Bryanne Perlanski and Marissa Olsen prosecuted the case, while attorney Jasper Mills represented Contompasis.

Contompasis claimed he was defending himself. Mills said he believed his client was the victim of an organized attack. It all came down to the video, he said.

Watch a video analysis of the melee:

"It boggles my mind. ... It kind of saddens me a little bit that people would see stuff like that and just not think that it was a big deal, or at least not big enough a deal to warrant some kind of self-defense," Mills told the Times Union. "But that's what they did."

Both victims testified, as did Contompasis. In a pre-trial hearing, the prosecutors highlighted Facebook posts that tied Contompasis to antifa, the decentralized movement of anti-fascist groups. The defendant had said he is not a member of any antifa group.

The judge made it clear last week he did not want the case to be about politics.

Ill tell both sides right now: This case is not going to be tried as a pro-Trump, anti-Trump case," McDonough said. "Its not going to be tried as an antifa, Proud Boys case. Its going to be tried on the facts.

The judge ordered Contompasis detained in the Albany County Jail as he awaits sentencing, which is scheduled for Nov. 18.

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Bitcoin falls after the jobs report, but crypto prices show relative stability – CNBC

Posted: at 3:59 pm

Chris Ratcliffe/Bloomberg via Getty Images

The crypto market fell with stocks after the highly anticipated jobs report showed the labor market is still tight and could keep the Federal Reserve on course to raise rates aggressively.

The price of bitcoin fell 3.3% to $19,380.74, according to Coin Metrics. Ether fell 2.7% to $1,322.40.

On Friday the Labor Department reported that the U.S. economy added 263,000 jobs in September, compared with the Dow Jones estimate of 275,000, and that the unemployment rate fell to 3.5% from 3.7% in the previous month.

"The jobs report points to no change of tune on the horizon for the Fed, so we continue to expect firm interest rates which also adds pressure to crypto markets," said Yung-Yu Ma, chief investment strategist at BMO Wealth Management.

Cryptocurrencies' correlation with stocks has weakened in recent weeks but remains high.

"Crypto looks to be at an important technical juncture here where it looks like it's trying to carve out a bottom, but feeling heavy," he added. "I still think it, more likely than not, breaks to the downside given rising interest rates and risk-off sentiment, but so far it's a surprising effort to hold the line."

The market has been in a good-news-is-bad-news holding pattern with the Federal Reserve laser focused on bring down inflation. While the new data shows strength in the U.S. economy, that could make the Fed more likely to continue with its aggressive rate hiking plan (whereas investors are hoping for a pause or a pivot), which puts pressure on stocks and weighs on crypto.

"Crypto has been the hardest hit by rate hike fears this year," said Callie Cox, U.S. investment analyst at eToro. "It makes sense many crypto projects don't have cashflows, so people invest in them for what they could be, not necessarily what value they're providing right now. When rates rise, the future value of a dollar falls."

Cox also highlighted the resilience of crypto assets in the second half of the year, noting that while stocks have revisited new lows with the spike in bond yields, bitcoin and ether haven't done the same. Bitcoin has been trading in a tight range of between $18,000 and $25,000 since falling to its lows of the year in June.

"To me, that's progress in this bear market," Cox said. "Crypto prices could be telling us the rate anxiety could be at a turning point. Crypto's strength is also a good indicator of frothiness in the market. It seems like the brutal growth selloff has finally washed out all the weak hands."

"Bitcoin is also far below its highs too," she added. "But stability is a step in the right direction."

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Bitcoin falls after the jobs report, but crypto prices show relative stability - CNBC

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The Upcoming Release Of Bitcoin Core 24.0 – Bitcoin Magazine

Posted: at 3:59 pm

Watch This Episode On YouTube Or Rumble

Listen To The Episode Here:

In this episode of Bitcoin, Explained, hosts Aaron van Wirdum and Sjors Provoost discuss the upcoming Bitcoin Core major release, Bitcoin Core 24.0.

The Bitcoin Core project produces a new major release of its software roughly every six months. The 24th major release is currently in its release candidate phase, which means that it is being tested and could technically be released any day now (though this phase will probably last a few more weeks). In the episode, van Wirdum and Provoost discuss seven of the most notable changes included in Bitcoin Core 24.0.

This includes a change to how nodes download blocks when they sync with the network. While previous Bitcoin Core versions started by downloading only block headers to make sure that the blocks they download have sufficient proof-of-work, Bitcoin Core 24.0 nodes will initially not store these block headers in order to prevent a certain type of resource exhaustion attack. Van Wirdum and Provoost explain that this should eventually also allow for the removal of any checkpoints in the Bitcoin Core codebase.

They go on to explain that Bitcoin Core 24.0 also includes an added option for users to apply full replace-by-fee (RBF) logic. Until now, Bitcoin Core nodes applied the first seen rule, which meant that conflicting transactions wouldnt be accepted in the node's memory pool (mempool) and forwarded to peers. With this upcoming release, users can choose to make their nodes accept and forward conflicting transactions if they include a higher fee than (the) earlier transaction(s) they conflict with.

Further upgrades discussed by van Wirdum and Provoost include a tool to migrate legacy wallets to descriptor wallets, initial miniscript support, default use of RBF when creating transactions, an improved unspent transaction output (UTXO) selection algorithm which randomizes change output amounts for extra privacy and a new send all function to spend a particular (set of) UTXO(s) in full.

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Bitcoin and Ethereum Forecast for the Week Ahead – DailyFX

Posted: at 3:59 pm

Bitcoin, Ethereum Talking Points

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Bitcoin and Ethereum continue to tread water above their YTD lows as economic data continues to allow for the Federal Reserve to remain aggressive in its battle against inflation. Nonfarm payrolls data on Friday showed that the US labor market continues to remain hot, albeit there are some signs of cooling. With the labor portion of the Feds mandate in check, Fed officials have indicated that will remain fully committed to returning inflation to target. As hawkish Fed policy shows no sign of abating, the outlook remains bleak for risk assets.

Despite the recent surge in US Treasury yields and collapse in equities, Bitcoin and Ethereum have both managed to keep their heads above water. While equities have pierced their June lows, Bitcoin and Ethereum have yet to break their respective lows. This could all change next week, as Thursdays CPI print could represent a major volatility event. Following the prior CPI release on September 13, risk markets tanked as inflation metrics increased.

US Economic Calendar

Courtesy of the DailyFX Economic Calendar

Despite the Friday rout in risk assets, Bitcoin continues to remain perky above recent swing lows. Price appears to be coiling around the key psychological level at $20,000, as price as consolidated into a tight range following the September 14th CPI print. Bulls have forcefully defended the $18500 area, while bears have prevented any break beyond $20400 from gaining steam. Price has notably made a series of higher lows this month, which offers support to the idea that something larger may be at play here. If markets were truly capitulating as many are looking for, highly speculative assets such as Bitcoin would likely not be showing such vibrant signs of life. While more price action is needed, an ascending triangle appears to be forming in BTCUSD. Should this formation materialize, higher prices may be ahead.

Chart created with TradingView

Like Bitcoin, Ethereum remains postured well above its YTD lows at $880. ETHUSD remains constrained to a much tighter range than Bitcoin, with price failing to materially break into a key pivot zone around $1400. Ethereum has largely struggled following the completion of the merge in September, with the network upgrade turning to be a sell the news event. As the outlook for risk continues to deteriorate, market participants may continue to follow economic data closely as Fed policy appears to drive all markets at the moment. With major event risk on the horizon next week, traders should keep an eye on how/if Ethereum breaks its recent range. While gravity continues to act forcefully on equities and bonds, crypto continues to defy the odds.

Chart created with TradingView

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Bitcoin and Ethereum Forecast for the Week Ahead - DailyFX

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Jim Cramer Says He Bought a Farm With Bitcoin ProfitsAnd Dares You to Bet Against Him – Decrypt

Posted: at 3:59 pm

CNBCs Jim Cramer prodded his myriad online non-believers on Friday with a challenge: bet against him. He dares you.

Cramer bragged to Crypto Twitter that hes divested from Bitcoin and Ethereum and bought a farm and boat with the spoils. He then coaxed doubters of his crypto market analyses to go all in on their anti-Cramer positions.

Soon, those doubters may be able to do precisely that.

According to an SEC filing from earlier this week, Tuttle Capital Management has applied to launch two exchange-traded fundsthe Inverse Cramer ETF (SJIM), and the Long Cramer ETF (LJIM)that will put an investors funds towards the opposite of whatever the outspoken television personality advises on his CNBC program Mad Money, and via his Twitter account.

The Fund is an actively managed exchange traded fund that seeks to achieve its investment objective by engaging in transactions designed to perform the opposite of the return of the investments recommended by television personality Jim Cramer (Cramer), the SEC filing reads. Under normal circumstances, at least 80% of the Funds investments is invested in the inverse of securities mentioned by Cramer.

The history of the relationship between Cramer and Crypto Twitter is long and storied. Once an ardent crypto bull who stated it was almost irresponsible not to buy Bitcoin, Cramer had a 180-degree change of heart once crypto markets crashed earlier this year.

On Twitter, apparent patterns of Cramers financial advice backfiring perfectly led to the emergence of a parody account titled Inverse Cramer ETF, which would gloat whenever Cramers prognostications turned out to be precisely incorrect.

As Cramer developed increasing skepticism of crypto assets in the aftermath of Mays crypto crash, the television host began accumulating an ironic following on Crypto Twitter, with users jokinglyor maybe notpositing that so long as Cramer continued to bash crypto, there was hope for the market.

Cramers statement today may have been some form of acknowledgement of the lack of deference his financial advice is now generally granted online, and potentially, of his awareness of a prospective batch of publicly traded, anti-Cramer financial products.

As one Twitter user posited though, what "Inception"-level event would transpire if Cramer ever turned bullish on the Inverse Cramer?

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Jim Cramer Says He Bought a Farm With Bitcoin ProfitsAnd Dares You to Bet Against Him - Decrypt

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