Monthly Archives: May 2022

What is DNA-based diet? Here’s how our genetic makeup is connected to nutrition – Hindustan Times

Posted: May 25, 2022 at 4:27 am

Several decades of nutrition research have shown us that no one-size diet fits all and since we are all unique, healthcare nutrition which applies to all doesn't fit everyone. Many factors come into play as to why it may happen but the main reason has something to do with our genes or genetic makeup.

Genomic testing determines the interplay between genes, nutrition and health. It helps personalise the diet and nutrition and provides you with a blueprint for optimal health and wellness.

What do genomic tests evaluate?

Genomic tests identify the specifics of our DNA, in terms of change in our chromosomes, associated genes and/or protein . Nutrigenetic DNA tests examine the genes and variants of these genes involved in specific nutrients and their metabolism.

What can genomic testing tell you?

Genomic testing can reveal a wide range of information, from your ancestry to your health and family history. For instance, genetic testing can screen and diagnose complex diseases, find out the risk and predisposition to disease, identify hereditary disease patterns and even help in creating a course on treatment, revealing a proclivity for nutrient deficiency or toxicity, food sensitivities and even whether you're at risk for nutrition-related diseases.

In an interview with HT Lifestyle, Dr Saima Naz Khan, Senior Manager- Scientific Affairs at Genes2Me Pvt Ltd, revealed, Every individual requires a balanced diet which should comprise macronutrients (carbohydrates, proteins, fats and fibers) and micronutrients (minerals and vitamins) but no individual neither requires nor responds to the exact amount of these nutrients; therefore, theres no one-size-fits-all diet. While several factors are at play, genetics plays a crucial role in our nutrition. Genomic testing can reveal why certain nutrients or diets works for an individual and why it doesnt work for others. There are nutrigenomics services that are truly useful for anyone who wants to be proactive about their health.

She added, A nutrigenomics counsellor may be able to advise you on certain eating patterns that will or will not work well for you based on your individual genetic makeup. For example, because of genomic tendencies for fat metabolism, gene variants may indicate that your body would not benefit from a vegan diet or would not adapt well to a keto diet. A nutrigenomic test can identify your personal best sources of macronutrients and micronutrients. Choosing a diet based on your genetic tendencies can help you achieve your health objectives.

Elaborating upon the same, Dr Akansha Sahay, General Physician at Tattvan E-clinic, said, Nutrigenomics, a science that studies interaction of nutrition and genes is flourishing and changing lives. DNA test for diet and nutrition can give us information about foods that can be healthy for us and ones which can pose a risk of various health conditions. Choosing a diet based on your genetic tendencies can help you to achieve your desired health goals.

She listed the factors whose information can be provided by DNA testing:

1. Vitamin and mineral deficiencies - calcium, iron, vitamin A, vitamin B, and more.

2. Bone mineral density (BMD)

3. Body Mass Index (BMI)

4. Response of macronutrients like carbohydrates, protein, fats and fibers on your weight.

5. Salt intake and blood pressure sensitivity

What is a DNA-based diet?

Dr Akansha Sahay explained, These diets are based on nutrigenomics, the study of the relationship between nutrition and the human genome. Examining ones DNA can help determine which diet would be most appropriate for ones health. A genetic test is undertaken to determine the correlation between a persons genes and nutrition level for their overall health. This info is primarily used by experts to pinpoint the best diet for them. Nutrigenomics is a wonder by which we can even correct cardiovascular disease, obesity, type 1 diabetes and other lifestyle diseases,Your DNA can influence not only your food behaviour, but is also capable of altering the expression of various hormones and enzymes critical to metabolism. These determine your response to diet, predisposition to weight gain and metabolism.

She said, Nutrigenomics (also known as nutritional genomics) is broadly defined as the relationship between nutrients, diet and gene expression. Phenylketonuria is an example of single gene mutation. About the examples of nutrigenomics, she said, Phenylketonuria patients should avoid phenylalanine-rich food. Many Asian populations have the problem of deficiency of the aldehyde dehydrogenase enzyme, which is responsible for metabolism of ethanol.

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Mechanism Shared by Mutations in Different Genes Associated With Autism, Schizophrenia, and Other Conditions Discovered – Neuroscience News

Posted: at 4:27 am

Summary: Researchers have identified a mechanism shared by mutations in the SHANK3 and ADNP genes. The genes have been associated with the development of ASD and schizophrenia.

Source: Tel Aviv University

Researchers at Tel Aviv University, led by Prof. Illana Gozes from the Department of Human Molecular Genetics and Biochemistry at the Sackler Faculty of Medicine and the Sagol School of Neuroscience, have unraveled a mechanism shared by mutations in the genes ADNP and SHANK3, which cause autism, schizophrenia, and other conditions.

The researchers also found that an experimental drug previously developed in Prof. Gozes lab is effective in lab models for these mutations and may be suitable for treating a range of rare syndromes that impair brain functions.

According to the researchers, the encouraging results may lead to effective treatments for a range of rare syndromes that impair brain functions and cause autism, schizophrenia, and neurodegenerative diseases like Alzheimers.

Participants in the study: Dr. Yanina Ivashko-Pachima, Maram Ganaiem, Inbar Ben-Horin-Hazak, Alexandra Lobyntseva, Naomi Bellaiche, Inbar Fischer, Gilad Levy, Dr. Shlomo Sragovich, Dr. Gidon Karmon, and Dr. Eliezer Giladi from the Sackler Faculty of Medicine and Sagol School of Neuroscience at TAU, Dr. Boaz Barak from the School of Psychological Sciences, Gershon H. Gordon Faculty of Social Sciences and the Sagol School of Neuroscience at TAU, and Dr. Shula Shazman from the Department of Mathematics and Computer Science at the Open University.

The paper was published in the scientific journalMolecular Psychiatry.

Prof. Gozes: Some cases of autism are caused by mutations in various genes. Today we know of more than 100 genetic syndromes associated with autism, 10 of which are considered relatively common (though still extremely rare).

In our lab we focus mainly on one of these, the ADNP syndrome, caused by mutations in the ADNP gene, which disrupt the function of the ADNP protein, leading to structural defects in the skeleton of neurons in the brain.

In the current study, we identified a specific mechanism that causes this damage in mutations in two different genes: ADNP and SHANK3 a gene associated with autism and schizophrenia. According to estimates, these two mutations are responsible for thousands of cases of autism around the world.

To start with, the researchers obtained cells from patients with ADNP syndrome. They discovered that when the ADNP protein is defective, neurons with faulty skeletons (microtubules) are formed, impairing brain functions. They also found, however, that ADNP mutations take different forms, some of which cause less damage.

Prof. Gozes, who is also Director of the Adams Super Center for Brain Studies at TAU, explains: We discovered that in some mutations, a section added to the protein protects it and reduces the damage by connecting to a control site of the neurons skeletal system. We know that this same control site is found on SHANK3 a much studied protein, with mutations that are associated with autism and schizophrenia.We concluded that the ability to bond with SHANK3 and other similar proteins provides some protection against the mutations damaging effects.

At the next stage of the study, the researchers found additional sites on the ADNP protein that can bond with SHANK3 and similar proteins. One of these sites is located on NAP, a section of ADNP which was developed into an experimental drug (Davunetide) by Prof. Gozes lab.

Moreover, the researchers demonstrated that extended treatment with Davunetide significantly improved the behavior of model animals with autism caused by SHANK3.

Prof. Gozes: In previous studies we showed that Davunetide is effective for treating ADNP syndrome models. The new study has led us to believe that it may also be effective in the case of Phelan McDermid syndrome, caused by a mutation in SHANK3, as well as other syndromes that cause autism through the same mechanism.

The experimental drug Davunetide was recognized by the FDA as an orphan and rare pediatric drug for future treatment of the developmental syndrome ADNP and is protected by patents through Ramot, the technology transfer company at Tel Aviv University and exclusively licensed to ATED Therapeutics Ltd.

ATED Therapeutics Ltd. (ATED)

ATED was formed around the work of Dr. Gozes by experienced business managers to develop Davunetide for clinical use. ATED is led by Dr. Jeff R. Swarz as CEO, Joe Chiarelli as CFO, an experienced clinical trial Chief Medical Officer, and Dr. Gozes as Chief Scientific Officer.

ATEDs broad focus is on diseases of the central nervous system (CNS). Our initial target is achronic, debilitatingform of autism called ADNP Syndrome (activity-dependent neuroprotective protein) that affects about 3,000-5,000 patients (ages 1-17) worldwide. The lead compound, Davunetide, is patented, safe, non-toxic, andhas been tested in over 300 adult patients. As there is no treatment for ADNP Syndrome, it has rare pediatric and orphan drug designation from the FDA.

Author: Noga ShaharSource: Tel Aviv UniversityContact: Noga Shahar Tel Aviv UniversityImage: The image is in the public domain

Original Research: Open access.SH3- and actin-binding domains connect ADNP and SHANK3, revealing a fundamental shared mechanism underlying autism by Yanina Ivashko-Pachima et al. Molecular Psychiatry

Abstract

SH3- and actin-binding domains connect ADNP and SHANK3, revealing a fundamental shared mechanism underlying autism

De novo heterozygous mutations in activity-dependent neuroprotective protein (ADNP) cause autistic ADNP syndrome. ADNP mutations impair microtubule (MT) function, essential for synaptic activity.

The ADNP MT-associating fragment NAPVSIPQ (called NAP) contains an MT end-binding protein interacting domain, SxIP (mimicking the active-peptide, SKIP). We hypothesized that not allADNPmutations are similarly deleterious and that the NAPV portion of NAPVSIPQ is biologically active.

Using the eukaryotic linear motif (ELM) resource, we identified a Src homology 3 (SH3) domain-ligand association site in NAP responsible for controlling signaling pathways regulating the cytoskeleton, namely NAPVSIP.

Altogether, we mapped multiple SH3-binding sites in ADNP. Comparisons of the effects of ADNP mutations p.Glu830synfs*83, p.Lys408Valfs*31, p.Ser404* on MT dynamics and Tau interactions (live-cell fluorescence-microscopy) suggested spared toxic function in p.Lys408Valfs*31, with a regained SH3-binding motif due to the frameshift insertion.

Site-directed-mutagenesis, abolishing the p.Lys408Valfs*31 SH3-binding motif, produced MT toxicity. NAP normalized MT activities in the face of all ADNP mutations, although, SKIP, missing the SH3-binding motif, showed reduced efficacy in terms of MT-Tau interactions, as compared with NAP.

Lastly, SH3 and multiple ankyrin repeat domains protein 3 (SHANK3), a major autism gene product, interact with the cytoskeleton through an actin-binding motif to modify behavior.

Similarly, ELM analysis identified an actin-binding site on ADNP, suggesting direct SH3 and indirect SHANK3/ADNP associations. Actin co-immunoprecipitations from mouse brain extracts showed NAP-mediated normalization of Shank3-Adnp-actin interactions.

Furthermore, NAP treatment ameliorated aberrant behavior in mice homozygous for theShank3ASD-linked InsG3680 mutation, revealing a fundamental shared mechanism between ADNP and SHANK3.

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Discovery of the link between the Patagonian sheepdog and the former shepherds from the UK – EurekAlert

Posted: at 4:27 am

image:Patagonian sheepdog view more

Credit: Rodrigo Muoz

The Patagonian sheepdog (PGOD) originated from the ancestral shepherds of the United Kingdom is nowadays the closest link to a now extinct population of shepherds from which modern herding breeds descend. This was shown by research recently published in the journal named PLOSGenetics.

The research was based on the genomic characterization of the Patagonian sheepdog. For this, it was necessary to take samples of 159 Patagonian sheepdogs from the region of Aysn and Magallanes, in addition to some of them belonging to the Province of Chubut, Argentina. In this route of almost 13.000 kilometers, hair samples and 22 body measurements were extracted, in addition to collecting information on their pastoralist behavior, health status, reproductive status and nutrition, among other data.

For Natasha Barrios, a member of Universidad Austral de Chile and who led the study, this Patagonia dog, unknown in the world, is shown as the missing link between the old shepherds of the United Kingdom and the modern herding breeds. In that line, she said that today we have an idea of what these dogs were and looked like before the official set up of modern breeds. It has been incredibly silent and stealthy working in the extreme of South America for the last 140 years, making it a valuable genetic and cultural reservoir.

DNA sequencing from blood samples was performed by means of a whole-genome genotyping chip. This chip has approximately 170.000 potential markers of polymorphisms within the dog's genome. To identify these variants, the obtained data were compared with data of similar characteristics from 1,514 individuals belonging to 175 recognized dog breeds, considering within this group herding breeds of European origin.

Regarding the advantages of this type of approach, Guillermo Nourdin, Bioinformatics expert at the MELISA Institute, who was responsible for the management and analysis of genomic data, highlighted the global, integrative and massive look at genomic data in the research. In addition, this approach identified common traits that match populations of Patagonian sheepdog together with modern herding dog breeds that have a common ancestor of European origin, he stated.

Finally, Prof. Elard Koch, senior researcher and Chairman at the MELISA Institute, said that they were pleased with the participation of Guillermo Nourdin in this study of Patagonian sheepdogs: "Collaborating with our bioinformatics capabilities in research as relevant as this one, is encouraging for our researchers and a major goal for our institution" Koch remarked.

This research opens the door to the future exploration of different phenotype-genotype association analyzes, which would, for example, the exploration of genetic traits associated with their behavior, resistance and ability to work; additionally, to search for possible diseases prone to some modern herding breeds, where Patagonian sheepdog could be key to understanding how and why they have spread today.

###

This work was funded by: National Research and Development Agency, FONDECYT 1181592, Chile. (https://www.anid.cl) to MAG, National Agency for Research and Development, National Doctoral Scholarship 2018, Chile (www.anid.cl) to NB, National Agency for Research and Development, REDI 170062, Chile (www.anid.cl) to CGL, National Agency for Research and Development, PIA/BASAL FB0002, Chile (www.anid.cl) to CGL, The Intramural Program of the National Human Genome Research Institute of the National Institute of Health, Bethesda, Maryland, United States of America to EAO, DLD, HGP, ANH. The sponsors had no role in the design of the study, the collection and analysis of data, the decision to publish or the preparation of the manuscript.

Participating researchers:

Natasha Barrios, Institute of Pharmacology and Morphophysiology, Graduate School, School of Veterinary Sciences, Southern University of Chile; Cesar Gonzalez-Lagos, Department of Sciences, School of Liberal Arts, Adolfo Ibanez University, Santiago, Chile, and Center for Applied Ecology and Sustainability (CAPES), Santiago, Chile; Dayna L. Dreger, Heidi G. Parker, Andrew N. Hogan and Elaine A. Ostrander, Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health (NIH), Bethesda, Maryland, USA; Guillermo Nourdin-Galindo, Biotechnology Division, MELISA Institute, Concepcion, Chile; Marcelo A. Gomez, Institute of Pharmacology and Morphophysiology, School of Veterinary Sciences, Universidad Austral de Chile, Valdivia, Chile.

Experimental study

Animals

Patagonian sheepdog: Genomic analyses trace the footprints of extinct UK herding dogs to South America

28-Apr-2022

Competing interests: The authors have declared that no competing interests exist.

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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Polygenic Risk Score Performance Improved With Expression-Related Rare Variant Insights – GenomeWeb

Posted: at 4:27 am

NEW YORK A team from Stanford University and other centers in the US and China have demonstrated that polygenic risk scores (PRS) based on common variants can be bolstered by incorporating clues from rare variants linked to significant gene expression shifts, dubbed expression outliers.

"As individual PRS estimates are comprised of variants across hundreds to thousands of genes, we reasoned that the disease effects of outlier-associated rare variants might have the greatest impact in individuals with a relatively larger burden of outlier-associated rare variant effects mapping to disease-relevant genes," Stanford University researchers Craig Smail and Stephen Montgomery, first and senior authors on a studyappearingin the American Journal of Human Genetics on Wednesday, explained in an email.

Using genotyping data from UK Biobank participants, together with expression quantitative trait locus data from the GTEx project and a computational method known as CrossMap that takes rare variant-related gene expression changes into account, the researchers first flagged rare variants with outsized effects on gene expression.

From nearly 1.8 million rare variants found in the UK Biobank set and in the gnomAD database, they flagged nearly 90,900 rare outlier variants that appeared to impact the expression of 15,871 genes, based on rare variant annotations gleaned from whole-genome and transcriptome sequences in version 8 of the GTEx.

From there, the team used its "independent outlier gene count" (IOGC) score to demonstrate that the expression outlier-related rare variants could improve the performance of body mass index (BMI) PRSs in more than 96,600 of the UK Biobank participants, distinguishing between individuals at higher or lower risk of so-called severe obesity or early bariatric surgery findings that were further validated using data for Million Veteran Program participants.

"We have demonstrated that a high burden of rare variants identified by their association with outlier gene expression can lead to substantial deviations in PRS-predicted phenotype," the authors wrote. "Furthermore, by integrating these rare variants into genetic risk prediction using the IOGC score, we demonstrated improvements in predicting risk for obesity beyond what was achievable with common variant-based PRSs."

In particular, the investigators found that predictions made using expression outlier-linked rare variants outperformed those possible by incorporating insights on protein-truncating rare variants into PRSs. Based on UK Biobank GWAS data spanning more than 1,900 traits or conditions, meanwhile, they saw signs that gene expression outlier-linked variants were somewhat enriched compared to rare variants that did not shift gene expression.

The findings so far suggest that "prediction for multiple complex diseases will benefit from integrating outlier-associated rare variants, including coronary heart disease, type 2 diabetes, and breast cancer," Smail and Montgomery wrote, noting that preliminary work points to improved predictive accuracy in at least two populations, hinting that a similar strategy may boost efforts to apply PRSs in non-European cohorts.

The investigators cautioned that the current approach is reliant on rare variant annotation insights from a relatively small set of GTEx representatives so far, and may be further improved by tapping into growing RNA sequence datasets and resulting variant-gene expression annotations. Likewise, whole-genome sequences from the UK Biobank project are expected to reveal far more rare variants missed with more limited sequence data used in the current analysis.

Consequently, Smail and Montgomery called the current work "a baseline for phenotypic prediction of complex diseases by integrating outlier-associated rare variants."

"Future extensions to our model will include more rare variants as we continue to sequence both transcriptomes and genomes in populations, will look at tissue-specific outlier effects, and incorporate longer-range gene expression impacts such as outlier-associated rare variants in enhancer regions," they noted.

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Why some ancient societies were more unequal than others – BBC

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This kind of first-degree offspring is extraordinary, only having been cited in royal families of the past headed by god-kings such as the Egyptian pharaohs seeking to maintain a pure dynastic bloodline. (It is known, for instance, that Akhenaten married his eldest daughter, Meritaten, and much later, Ptolemy II married his sister, Arsinoe II hence his nickname, "Philadelphus" or "sibling loving.") It has been suggested that this Neolithic elite may have claimed to possess divine powers to ensure the continuity of agricultural cycles by keeping the Sun's movements going.

The findings support the notion that these Neolithic communities were socially stratified and that the massive stone structures were used to bury transgenerational patrilineal members of these clans. Perhaps equally interesting is the fact that in one case relatives were separated by up to 12 generations, pointing to an unusual stability through time of both the funerary tradition and the stratified society where they lived.

We have seen several case studies of past inequality correlating funerary archaeology with genetics that might no longer apply today, where legal regulations (and also the exponential increase of cremations) represent a certain degree of standardisation in funeral practices. Nevertheless, an opposite trend could shape thefuture of the archaeology of death: the trend toward personalised coffins, unconventional funerary memorials, and special grave goods. One way or another, mortuary archaeology will always be an important subfield of this discipline, and one that will need to rely on the hard sciences such as genetics and forensics.

Perhaps one encouraging conclusion is that despite what we have seen on the archaeology of past inequality, societies have been able to evolve and change their social stratifications. One example is Iceland the country has become one of the most egalitarian societies in the world. In 2018, Iceland passed a law that all companies employing more than 25 people will have four years to ensure gender-equal payment because, according to the head of the Equality Unit at Iceland's Welfare Ministry, "equality won't come about by itself, from the bottom up alone".

* This is an edited version of an article thatoriginally appearedinThe MIT Press Reader, and is republished with permission.

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Carles Lalueza-Foxis Research Professor and Director of the Paleogenomics Lab at the Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra) in Barcelona. He participated in the Neanderthal Genome Project and led the first retrieval of the genome of an 8,000-year-old European hunter-gatherer. He is the author of Inequality: A Genetic History, from which this article is adapted (this is an edited version of the original MIT Reader piece).

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Man charged in connection with sexual offences against teenage girls in Chester – Deeside.com

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Deeside.com > News

Posted: Tue 24th May 2022

Detectives have charged a man from Chester with sexual assault offences.

William Forsyth, of Sealand Road, was arrested shortly after 4pm on Sunday 22 May on George Street.

The 53-year-old was subsequently charged with two counts of sexual assault, an attempted sexual assault and a public order offence.

He was remanded in custody and appeared at Chester Magistrates Court today, Tuesday 24 May.

Forsyth was further remanded in custody and is due to appear at Chester Crown Court on Monday 11 July.

The charges relate to reports of four girls, aged 15 to 17, allegedly inappropriately touched by a man in the vicinity of the bus interchange in Chester city centre on the afternoon of Sunday 22 May.

If anyone has information please contact Cheshire Constabulary onlinehttps://www.cheshire.police.uk/tell-usor via 101 quoting IML 1275305.

Spotted something? Got a story? Send a Facebook Message | A direct message on Twitter | Email: News@Deeside.com

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Vote count postponed in Butwal : Who broke the ballot box seal and why? – Myrepublica

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BUTWAL, May 19: The counting of votes in Butwal Sub-Metropolitan City has been postponed. The counting was halted after a dispute arose during the counting of votes of ward 11.

According to the Office of the Returning Officer, the seal of one of the 11 ballot boxes was broken and the seal was found on the cloth. So far, the Nepali Congress has been taking the lead in the counting of votes.

CPN-UML cadres have been protesting saying that the seal of one of the ballot boxes of the ward they were confident about was found broken. However, of the four seals in the ballot boxes, only one was found in the cloth in a broken condition, according to the Office of the Returning Officer.

According to election officials, the security of the ballot boxes is the responsibility of the election office. They say, it is the responsibility of the election officials to take the responsibility of a broken seal in such a situation as no one other than the election staff and the security forces can enter the place.

A Nepali Congress leader said that the UML cadres, in cahoots with the employees close to UML, might have broken one of the four seals on the ballot box after the CPN-UML reached the point of defeat. Most of the employees participating in the election and vote counting process of Butwal are from Butwal Sub-metropolis. It is said that most of these employees are known as UML supporters.

The UML, which won the 2074 election by a huge margin, is now behind by 5,000 votes. The UML had won in ward 11 in 2074 BS by a huge margin of votes. But this time, due to the voting trend seen in other wards, this ward is also expected to slip out of UMLs hands and the Nepali Congress is likely to win here too.

Some have suspected that the UML may have mobilized its staff to carry out the scam. Leaders and cadres of the CPN-UML have accused the Nepali Congress of rigging the election. An all-party meeting is being convened after the dispute arose. The counting of votes in all other wards except ward 11 is underway.

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PTFE Compression Packing Market Research With Size, Growth, Key Players, Segments And Forecasts Analysis 2022-2028| KLINGER UK, SEPCO, Inc. The Daily…

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Table of Content

1 Study Coverage1.1 PTFE Compression Packing Product Introduction1.2 Market by Type1.2.1 Global PTFE Compression Packing Market Size by Type, 2017 VS 2021 VS 20281.2.2 Without Lubrication Type1.2.3 Lubrication Type1.3 Market by Application1.3.1 Global PTFE Compression Packing Market Size by Application, 2017 VS 2021 VS 20281.3.2 Water Treatment1.3.3 Chemical Processing1.3.4 Food Processing1.3.5 Industrial Gas Processing1.3.6 Others1.4 Study Objectives1.5 Years Considered2 Global PTFE Compression Packing Production2.1 Global PTFE Compression Packing Production Capacity (2017-2028)2.2 Global PTFE Compression Packing Production by Region: 2017 VS 2021 VS 20282.3 Global PTFE Compression Packing Production by Region2.3.1 Global PTFE Compression Packing Historic Production by Region (2017-2022)2.3.2 Global PTFE Compression Packing Forecasted Production by Region (2023-2028)2.4 North America2.5 Europe2.6 China2.7 Japan3 Global PTFE Compression Packing Sales in Volume & Value Estimates and Forecasts3.1 Global PTFE Compression Packing Sales Estimates and Forecasts 2017-20283.2 Global PTFE Compression Packing Revenue Estimates and Forecasts 2017-20283.3 Global PTFE Compression Packing Revenue by Region: 2017 VS 2021 VS 20283.4 Global PTFE Compression Packing Sales by Region3.4.1 Global PTFE Compression Packing Sales by Region (2017-2022)3.4.2 Global Sales PTFE Compression Packing by Region (2023-2028)3.5 Global PTFE Compression Packing Revenue by Region3.5.1 Global PTFE Compression Packing Revenue by Region (2017-2022)3.5.2 Global PTFE Compression Packing Revenue by Region (2023-2028)3.6 North America3.7 Europe3.8 Asia-Pacific3.9 Latin America3.10 Middle East & Africa4 Competition by Manufactures4.1 Global PTFE Compression Packing Production Capacity by Manufacturers4.2 Global PTFE Compression Packing Sales by Manufacturers4.2.1 Global PTFE Compression Packing Sales by Manufacturers (2017-2022)4.2.2 Global PTFE Compression Packing Sales Market Share by Manufacturers (2017-2022)4.2.3 Global Top 10 and Top 5 Largest Manufacturers of PTFE Compression Packing in 20214.3 Global PTFE Compression Packing Revenue by Manufacturers4.3.1 Global PTFE Compression Packing Revenue by Manufacturers (2017-2022)4.3.2 Global PTFE Compression Packing Revenue Market Share by Manufacturers (2017-2022)4.3.3 Global Top 10 and Top 5 Companies by PTFE Compression Packing Revenue in 20214.4 Global PTFE Compression Packing Sales Price by Manufacturers4.5 Analysis of Competitive Landscape4.5.1 Manufacturers Market Concentration Ratio (CR5 and HHI)4.5.2 Global PTFE Compression Packing Market Share by Company Type (Tier 1, Tier 2, and Tier 3)4.5.3 Global PTFE Compression Packing Manufacturers Geographical Distribution4.6 Mergers & Acquisitions, Expansion Plans5 Market Size by Type5.1 Global PTFE Compression Packing Sales by Type5.1.1 Global PTFE Compression Packing Historical Sales by Type (2017-2022)5.1.2 Global PTFE Compression Packing Forecasted Sales by Type (2023-2028)5.1.3 Global PTFE Compression Packing Sales Market Share by Type (2017-2028)5.2 Global PTFE Compression Packing Revenue by Type5.2.1 Global PTFE Compression Packing Historical Revenue by Type (2017-2022)5.2.2 Global PTFE Compression Packing Forecasted Revenue by Type (2023-2028)5.2.3 Global PTFE Compression Packing Revenue Market Share by Type (2017-2028)5.3 Global PTFE Compression Packing Price by Type5.3.1 Global PTFE Compression Packing Price by Type (2017-2022)5.3.2 Global PTFE Compression Packing Price Forecast by Type (2023-2028)6 Market Size by Application6.1 Global PTFE Compression Packing Sales by Application6.1.1 Global PTFE Compression Packing Historical Sales by Application (2017-2022)6.1.2 Global PTFE Compression Packing Forecasted Sales by Application (2023-2028)6.1.3 Global PTFE Compression Packing Sales Market Share by Application (2017-2028)6.2 Global PTFE Compression Packing Revenue by Application6.2.1 Global PTFE Compression Packing Historical Revenue by Application (2017-2022)6.2.2 Global PTFE Compression Packing Forecasted Revenue by Application (2023-2028)6.2.3 Global PTFE Compression Packing Revenue Market Share by Application (2017-2028)6.3 Global PTFE Compression Packing Price by Application6.3.1 Global PTFE Compression Packing Price by Application (2017-2022)6.3.2 Global PTFE Compression Packing Price Forecast by Application (2023-2028)7 North America7.1 North America PTFE Compression Packing Market Size by Type7.1.1 North America PTFE Compression Packing Sales by Type (2017-2028)7.1.2 North America PTFE Compression Packing Revenue by Type (2017-2028)7.2 North America PTFE Compression Packing Market Size by Application7.2.1 North America PTFE Compression Packing Sales by Application (2017-2028)7.2.2 North America PTFE Compression Packing Revenue by Application (2017-2028)7.3 North America PTFE Compression Packing Sales by Country7.3.1 North America PTFE Compression Packing Sales by Country (2017-2028)7.3.2 North America PTFE Compression Packing Revenue by Country (2017-2028)7.3.3 United States7.3.4 Canada8 Europe8.1 Europe PTFE Compression Packing Market Size by Type8.1.1 Europe PTFE Compression Packing Sales by Type (2017-2028)8.1.2 Europe PTFE Compression Packing Revenue by Type (2017-2028)8.2 Europe PTFE Compression Packing Market Size by Application8.2.1 Europe PTFE Compression Packing Sales by Application (2017-2028)8.2.2 Europe PTFE Compression Packing Revenue by Application (2017-2028)8.3 Europe PTFE Compression Packing Sales by Country8.3.1 Europe PTFE Compression Packing Sales by Country (2017-2028)8.3.2 Europe PTFE Compression Packing Revenue by Country (2017-2028)8.3.3 Germany8.3.4 France8.3.5 U.K.8.3.6 Italy8.3.7 Russia9 Asia Pacific9.1 Asia Pacific PTFE Compression Packing Market Size by Type9.1.1 Asia Pacific PTFE Compression Packing Sales by Type (2017-2028)9.1.2 Asia Pacific PTFE Compression Packing Revenue by Type (2017-2028)9.2 Asia Pacific PTFE Compression Packing Market Size by Application9.2.1 Asia Pacific PTFE Compression Packing Sales by Application (2017-2028)9.2.2 Asia Pacific PTFE Compression Packing Revenue by Application (2017-2028)9.3 Asia Pacific PTFE Compression Packing Sales by Region9.3.1 Asia Pacific PTFE Compression Packing Sales by Region (2017-2028)9.3.2 Asia Pacific PTFE Compression Packing Revenue by Region (2017-2028)9.3.3 China9.3.4 Japan9.3.5 South Korea9.3.6 India9.3.7 Australia9.3.8 China Taiwan9.3.9 Indonesia9.3.10 Thailand9.3.11 Malaysia10 Latin America10.1 Latin America PTFE Compression Packing Market Size by Type10.1.1 Latin America PTFE Compression Packing Sales by Type (2017-2028)10.1.2 Latin America PTFE Compression Packing Revenue by Type (2017-2028)10.2 Latin America PTFE Compression Packing Market Size by Application10.2.1 Latin America PTFE Compression Packing Sales by Application (2017-2028)10.2.2 Latin America PTFE Compression Packing Revenue by Application (2017-2028)10.3 Latin America PTFE Compression Packing Sales by Country10.3.1 Latin America PTFE Compression Packing Sales by Country (2017-2028)10.3.2 Latin America PTFE Compression Packing Revenue by Country (2017-2028)10.3.3 Mexico10.3.4 Brazil10.3.5 Argentina10.3.6 Colombia11 Middle East and Africa11.1 Middle East and Africa PTFE Compression Packing Market Size by Type11.1.1 Middle East and Africa PTFE Compression Packing Sales by Type (2017-2028)11.1.2 Middle East and Africa PTFE Compression Packing Revenue by Type (2017-2028)11.2 Middle East and Africa PTFE Compression Packing Market Size by Application11.2.1 Middle East and Africa PTFE Compression Packing Sales by Application (2017-2028)11.2.2 Middle East and Africa PTFE Compression Packing Revenue by Application (2017-2028)11.3 Middle East and Africa PTFE Compression Packing Sales by Country11.3.1 Middle East and Africa PTFE Compression Packing Sales by Country (2017-2028)11.3.2 Middle East and Africa PTFE Compression Packing Revenue by Country (2017-2028)11.3.3 Turkey11.3.4 Saudi Arabia11.3.5 UAE12 Corporate Profiles12.1 KLINGER UK12.1.1 KLINGER UK Corporation Information12.1.2 KLINGER UK Overview12.1.3 KLINGER UK PTFE Compression Packing Sales, Price, Revenue and Gross Margin (2017-2022)12.1.4 KLINGER UK PTFE Compression Packing Product Model Numbers, Pictures, Descriptions and Specifications12.1.5 KLINGER UK Recent Developments12.2 SEPCO, Inc.12.2.1 SEPCO, Inc. Corporation Information12.2.2 SEPCO, Inc. Overview12.2.3 SEPCO, Inc. PTFE Compression Packing Sales, Price, Revenue and Gross Margin (2017-2022)12.2.4 SEPCO, Inc. PTFE Compression Packing Product Model Numbers, Pictures, Descriptions and Specifications12.2.5 SEPCO, Inc. Recent Developments12.3 James Walker12.3.1 James Walker Corporation Information12.3.2 James Walker Overview12.3.3 James Walker PTFE Compression Packing Sales, Price, Revenue and Gross Margin (2017-2022)12.3.4 James Walker PTFE Compression Packing Product Model Numbers, Pictures, Descriptions and Specifications12.3.5 James Walker Recent Developments12.4 Garlock12.4.1 Garlock Corporation Information12.4.2 Garlock Overview12.4.3 Garlock PTFE Compression Packing Sales, Price, Revenue and Gross Margin (2017-2022)12.4.4 Garlock PTFE Compression Packing Product Model Numbers, Pictures, Descriptions and Specifications12.4.5 Garlock Recent Developments12.5 Delmar Company12.5.1 Delmar Company Corporation Information12.5.2 Delmar Company Overview12.5.3 Delmar Company PTFE Compression Packing Sales, Price, Revenue and Gross Margin (2017-2022)12.5.4 Delmar Company PTFE Compression Packing Product Model Numbers, Pictures, Descriptions and Specifications12.5.5 Delmar Company Recent Developments12.6 Phelps12.6.1 Phelps Corporation Information12.6.2 Phelps Overview12.6.3 Phelps PTFE Compression Packing Sales, Price, Revenue and Gross Margin (2017-2022)12.6.4 Phelps PTFE Compression Packing Product Model Numbers, Pictures, Descriptions and Specifications12.6.5 Phelps Recent Developments12.7 Sunwell Gasket12.7.1 Sunwell Gasket Corporation Information12.7.2 Sunwell Gasket Overview12.7.3 Sunwell Gasket PTFE Compression Packing Sales, Price, Revenue and Gross Margin (2017-2022)12.7.4 Sunwell Gasket PTFE Compression Packing Product Model Numbers, Pictures, Descriptions and Specifications12.7.5 Sunwell Gasket Recent Developments12.8 Vulcan12.8.1 Vulcan Corporation Information12.8.2 Vulcan Overview12.8.3 Vulcan PTFE Compression Packing Sales, Price, Revenue and Gross Margin (2017-2022)12.8.4 Vulcan PTFE Compression Packing Product Model Numbers, Pictures, Descriptions and Specifications12.8.5 Vulcan Recent Developments12.9 Hi-Tech Sealing & Insulation Industries12.9.1 Hi-Tech Sealing & Insulation Industries Corporation Information12.9.2 Hi-Tech Sealing & Insulation Industries Overview12.9.3 Hi-Tech Sealing & Insulation Industries PTFE Compression Packing Sales, Price, Revenue and Gross Margin (2017-2022)12.9.4 Hi-Tech Sealing & Insulation Industries PTFE Compression Packing Product Model Numbers, Pictures, Descriptions and Specifications12.9.5 Hi-Tech Sealing & Insulation Industries Recent Developments12.10 CIXI HIGH NEW (COXIN) SEALING MATERIAL CO.,LTD.12.10.1 CIXI HIGH NEW (COXIN) SEALING MATERIAL CO.,LTD. Corporation Information12.10.2 CIXI HIGH NEW (COXIN) SEALING MATERIAL CO.,LTD. Overview12.10.3 CIXI HIGH NEW (COXIN) SEALING MATERIAL CO.,LTD. PTFE Compression Packing Sales, Price, Revenue and Gross Margin (2017-2022)12.10.4 CIXI HIGH NEW (COXIN) SEALING MATERIAL CO.,LTD. PTFE Compression Packing Product Model Numbers, Pictures, Descriptions and Specifications12.10.5 CIXI HIGH NEW (COXIN) SEALING MATERIAL CO.,LTD. Recent Developments12.11 Robco Inc.12.11.1 Robco Inc. Corporation Information12.11.2 Robco Inc. Overview12.11.3 Robco Inc. PTFE Compression Packing Sales, Price, Revenue and Gross Margin (2017-2022)12.11.4 Robco Inc. PTFE Compression Packing Product Model Numbers, Pictures, Descriptions and Specifications12.11.5 Robco Inc. Recent Developments12.12 Sealmax12.12.1 Sealmax Corporation Information12.12.2 Sealmax Overview12.12.3 Sealmax PTFE Compression Packing Sales, Price, Revenue and Gross Margin (2017-2022)12.12.4 Sealmax PTFE Compression Packing Product Model Numbers, Pictures, Descriptions and Specifications12.12.5 Sealmax Recent Developments12.13 American Seal and Packing12.13.1 American Seal and Packing Corporation Information12.13.2 American Seal and Packing Overview12.13.3 American Seal and Packing PTFE Compression Packing Sales, Price, Revenue and Gross Margin (2017-2022)12.13.4 American Seal and Packing PTFE Compression Packing Product Model Numbers, Pictures, Descriptions and Specifications12.13.5 American Seal and Packing Recent Developments13 Industry Chain and Sales Channels Analysis13.1 PTFE Compression Packing Industry Chain Analysis13.2 PTFE Compression Packing Key Raw Materials13.2.1 Key Raw Materials13.2.2 Raw Materials Key Suppliers13.3 PTFE Compression Packing Production Mode & Process13.4 PTFE Compression Packing Sales and Marketing13.4.1 PTFE Compression Packing Sales Channels13.4.2 PTFE Compression Packing Distributors13.5 PTFE Compression Packing Customers14 Market Drivers, Opportunities, Challenges and Risks Factors Analysis14.1 PTFE Compression Packing Industry Trends14.2 PTFE Compression Packing Market Drivers14.3 PTFE Compression Packing Market Challenges14.4 PTFE Compression Packing Market Restraints15 Key Finding in The Global PTFE Compression Packing Study16 Appendix16.1 Research Methodology16.1.1 Methodology/Research Approach16.1.2 Data Source16.2 Author Details16.3 Disclaimer

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PTFE Compression Packing Market Research With Size, Growth, Key Players, Segments And Forecasts Analysis 2022-2028| KLINGER UK, SEPCO, Inc. The Daily...

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Blockchain Technology in Transportation and Logistics Market: 3-Key Growth Scenarios | Accenture, Capgemini Services, Infosys Carbon Valley Farmer…

Posted: at 4:26 am

The latest independent research document on Global Blockchain Technology in Transportation and Logistics examine investment inMarket. It describes how companies deploying these technologies across various industry verticals aim to explore its potential to become a major business disrupter. The Blockchain Technology in Transportation and Logistics study eludes very useful reviews & strategic assessment including the generic market trends, emerging technologies, industry drivers, challenges, regulatory policies that propel the market growth, along with major players profile and strategies. This version of Blockchain Technology in Transportation and Logistics market report advocates analysis of Accenture Plc, Capgemini Services SAS, Infosys Ltd., IBM, Azure, Oracle Corp., SAP, Tata Consultancy Services Ltd., Wipro Ltd., EXL Service, DAC.digital, Arcbest, Transportation Impact & ?Blockchain Technology in Transportation and LogisticsMarket Scope and Market Breakdown.

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As Blockchain Technology in Transportation and Logistics research and application [Sea, Land] continues to expand in scope, the market will see deeper integration and application of more technologies in the future. This commercialization of market is playing a positive role in accelerating Blockchain Technology in Transportation and Logistics business digitalization, improving industry chain structures and enhancing information use efficiency. The findings mainly focus on category or product type: Software & Service etc, which underpins many recent advances in the other Blockchain Technology in Transportation and Logistics technologies.

In order to provide a more informed view, Blockchain Technology in Transportation and Logistics research offers a snapshot of the current state of the rapidly changing industry, looking through the lenses of both end users and service provides/players ofto come up with a more robust view.

Market Scope

Based on the type of product, the market segmented into : Software & Service

Based on the End use application, the market segmented into : Sea, Land]

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Regional Landscape

Geographically, the Blockchain Technology in Transportation and Logistics market size by revenue is broken down by 18+ countries fromNorth America, LATAM, the Middle East, Asia Pacific, Africa, and Europebased on various characteristics such as geographic footprints and business operation locations of players.

Analysts at HTF MI sheds light on Blockchain Technology in Transportation and Logistics market data by Country

Asia-Pacific (Vietnam, China, Malaysia, Japan, Philippines, South Korea, Thailand, India, Indonesia, Australia and Others)Europe (Germany, Russia, the UK, Italy, France, Spain, Belgium, Netherlands, Switzerland, Nordic Nations, Rest of Europe.)North America (the United States, Mexico, and Canada)South America (Brazil, Argentina, Chile, Rest of South America)Middle East and Africa (GCC Countries, Turkey, Israel, South Africa, Egypt and Rest of MEA)

The Blockchain Technology in Transportation and Logistics study cites various market development activities and business strategies such as new product/services development, Joint Ventures, partnerships, mergers and acquisitions, etc that Industry players such as Accenture Plc, Capgemini Services SAS, Infosys Ltd., IBM, Azure, Oracle Corp., SAP, Tata Consultancy Services Ltd., Wipro Ltd., EXL Service, DAC.digital, Arcbest, Transportation Impact & ?Blockchain Technology in Transportation and LogisticsMarket Scope and Market Breakdown are utilizing to overcome macro-economic scenarios. The Blockchain Technology in Transportation and Logistics Market company profiles include Business Overview, Product / Service Offerings, SWOT Analysis, Segment & Total Revenue, Gross Margin and % Market Share.

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Extracts from Global Blockchain Technology in Transportation and Logistics Market Study

1. Market Snapshot2. Global Blockchain Technology in Transportation and Logistics Market Factor Analysis Value Chain Analysis Growth Drivers, Trends and Challenges Porters 5- Forces Analysis PESTEL Analysis3.Blockchain Technology in Transportation and Logistics Market by Type (2017-2027) [Software & Service]4. Market by Applications/ End Users (2017-2027) [Sea, Land]5.Blockchain Technology in Transportation and Logistics Market: Country Landscape6. Market Size Breakdown for Each Country7. Competitive Landscape Market Share Analysis by Players Company Profiles

.. Continued

Data Sources & Methodology

The primary sources involve the industry experts from the Global Blockchain Technology in Transportation and Logistics Market including the management organizations, processing organizations, service providers of the industrial value chain. In the extensive research process undertaken for this study, the primary sources considered such as Postal Surveys, telephone, Online & Face-to-Face Survey to obtain and verify both qualitative and quantitative aspects. When it comes to secondary sources Companys Annual reports, press Releases, Websites, Investor Presentation, Conference Call transcripts, Webinar, Journals, Regulators, National Customs and Industry Associations were used.

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Blockchain Technology in Transportation and Logistics Market: 3-Key Growth Scenarios | Accenture, Capgemini Services, Infosys Carbon Valley Farmer...

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Are sea lions and seals eating too much of B.C.s salmon? The answer may lead to a cull – Toronto Star

Posted: at 4:26 am

COWICHAN BAY, B.C.The seals and sea lions gathered around the docks of Cowichan Bay on Vancouver Island are a beautiful sight.

Some are sleeping, some are barking, while others are playing in the water. For the throng of visitors vacationing this summer, seeing a sea lion scarf down a whole salmon in two bites is a West Coast moment theyll never forget.

But an increasing number of the protected seals and sea lions (larger than seals, sea lions can walk) may be upsetting the balance of the British Columbia marine ecosystem. Now some First Nations are proposing a cull.

Environmentalists trying to stop traditional seal and sea lion hunts are trying to starve out the Indians, says Tom Sewid of the Kwakwakwakw First Nation on northeastern Vancouver Island. I wont put up with it.

And as seals and sea lions have prospered, salmon have struggled.

The demise of the salmon runs in British Columbia is equivalent if not greater than the extinction of the great buffalo herds across the Great Plains in the 1800s, says Sewid. His First Nations Pacific Balance Marine Management group is advocating a return to traditional seal and sea lion hunts to balance the ecosystem.

While tourists take pictures, Tim Kulchyski, a Cowichan tribe natural resource expert, stands on the shore and counts the aquatic mammals. The number of sea lions they can weigh as much as 2,200 pounds has tripled in his lifetime, says the middle-aged man. And as their numbers grow, they are consuming ever more of the regions coveted salmon stock, waiting by river mouths to catch salmon fry as they swim out to sea or mature salmon as they return to spawn.

The problem of seals and sea lions pilfering the fish is as old as British Columbia. At the turn of the 20th century, the B.C. government paid hunters a $2 bounty for every nose to protect the profitable fisheries. Later, the government deployed military gunner crews to exterminate what it called the mammoth marauders, according to media reports.

But a 1970s ban on the hunt and commercial harvests has allowed seals and sea lion populations to flourish. Warmer waters have also encouraged sea lions from California to migrate farther north and stay in British Columbia, according to experts.

Many sport and commercial fishing advocates see the First Nation-led movement as their best chance at reducing seal and sea lion populations. Currently, B.C. Indigenous groups are allowed to kill seals and sea lions only for ceremonial purposes, but Pacific Balance Marine Management is teaching tribes how to harvest the animals for human food, pet food, clothing and oil as a way to earn income.

The group raises funds to offset hunter ammunition and gas expenses and support the Aboriginal Front Door Society in Vancouvers Downtown East Side, which serves sea lion (Tibin) stew to homeless visitors.

But there is mixed opinion among scientists on whether the growing numbers of seals and sea lions is linked to the decline of salmon.

Benjamin Nelson, a quantitative ecologist, says his work with Dr. Andrew Trites at the University of British Columbia found an association between an abundance of seals and declines in salmon, but not a smoking gun.

We think seals are threatening salmon but we havent proved it, says Nelson, who says sea lions are more difficult to study because they migrate up and down the Pacific coast.

Some studies show that only a small minority of seals and sea lions consume salmon in large quantities, says Wilf Luedke, a district head at the federal Department of Fisheries and Oceans (DFO). And some scientists worry that getting rid of seals could actually reduce salmon, as seals eat other fish that eat salmon.

So as we try to figure out how to rebuild the salmon, we see seals as a potentially high-risk, but with a high degree of uncertainty.

Dr. Carl Waters, professor emeritus of oceans and fisheries at UBC, argues that sea lions alone now consume more fish than all B.C. fisheries combined. Seal and sea lion diets are not high in salmon, Walters says, but the types they target at particular times of the year, for example during spawning migrations, have high impacts.

The regions beloved orcas are caught in this mesh as well. The southern resident group of whales eat only salmon and themselves are threatened by seals and sea lions. But transient orcas prey on seals and sea lions and they are thriving in greater numbers as seals and sea lions thrive, says Jay Ritchlin, a director general at the David Suzuki Foundation.

Marine ecology is complex, says Ritchlin, and isolating and killing one species to get more of another might do more harm than good.

I think its a unique human attribute, says Ritchlin, to blame other animals for problems that we have caused and then kill them to get back to a situation that we undermined in the first place. Humans,not seals or sea lions, have disrupted the ecological balance, he says. We need to give our heads a shake.

The province also needs to eliminate fish farms located near wild salmon, repair habitat where they spawn, reduce wastewater and restrict fishing to bring the ecosystem back in balance, says Ritchlin. Im not convinced that hunting seals is an important piece of the equation.

Both sides of the debate support better understanding the interactions.

Benjamin thinks allowing small-scale First Nations harvesting as an experiment that is monitored is a good first step. And the stomach contents of animals harvested are being sent to researchers to study just how much salmon they are consuming.

And trying to understand the interaction of all species is essential, Kulchyski says. For thousands of years, seals, sea lions, salmon and orcas have coexisted in a complex relationship.

Ritchlin agrees, and his advice to visitors this summer is simple: Come and enjoy and appreciate how complex this ecosystem is, and how it all works together.

Katharine Lake Berz is a writer based on Vancouver Island and in Toronto

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Are sea lions and seals eating too much of B.C.s salmon? The answer may lead to a cull - Toronto Star

Posted in Sealand | Comments Off on Are sea lions and seals eating too much of B.C.s salmon? The answer may lead to a cull – Toronto Star