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Monthly Archives: March 2022
Estimated Changes in Direct Spending and Revenues Under H.R. 3617, the MORE Act – Congressional Budget Office
Posted: March 31, 2022 at 2:30 am
H.R. 3617 would federally decriminalize cannabis (marijuana), expunge the records of people convicted of federal cannabis offenses, and require resentencing of some federal prisoners. As a result, CBO estimates, thousands of current inmates would be released earlier than under current law. In the future, decriminalization also would reduce the number of people in federal prisons and the amount of time they serve. CBO estimates that over the 2022-2031 period, H.R. 3617 would reduce time served by current and future inmates by 37,000 person-years. CBOs analysis accounts for time served by offenders convicted of cannabis-only crimes and time served by people convicted of a crime in addition to a cannabis offense.
Federal prisoners generally are not eligible for federal benefit programs. By reducing the prison population, CBO and the staff of the Joint Committee on Taxation (JCT) estimate, H.R. 3617 would increase the number of people eligible for federal benefits, compared with current law. That change would increase direct spending for federal benefit programs by $344 million over the 2022-2031 period and reduce revenues by $6 million over that same period.
CBO and JCT estimate that H.R. 3617 would increase revenues, on net, by about $8.1 billion over the 2022-2031 period by creating an occupational tax on cannabis producers and warehouse operators and by increasing compliance with business income taxes. Those increases would be partially offset by allowing businesses to claim certain deductions and credits for expenses that would include the costs of producing, importing, and marketing cannabis products. In addition, the bill would impose an excise tax on cannabis products produced in or imported into the United States.
H.R. 3617 would create a new Opportunity Trust Fund and would appropriate to the fund amounts equivalent to the net revenues received from the occupational tax and from excise taxes on cannabis products. CBO estimates that about $7.8 billion would be appropriated to the fund over the 2022-2031 period, of which the Department of Justice would spend about $3.4 billion to provide job training and legal aid, among other services, to people harmed by what was termed the war on drugs. CBO also estimates that the Small Business Administration would provide about $1.4 billion in grants to states and localities to make business loans to related small businesses and to develop cannabis-licensing rules.
Finally, H.R. 3617 would reduce the Bureau of Prisons costs by reducing both the number of people in federal facilities and the amount of time they serve. CBO estimates that the provision would result in net savings of about $800 million over the 2022-2031 period, assuming appropriation actions consistent with the anticipated changes in prison populations. Those savings are not reflected in the table because they are subject to future appropriation action.
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Britain withdraws its judges from Hong Kong’s top court – NPR
Posted: at 2:29 am
The Lady Justice statue stands atop the Final Court of Appeal in Hong Kong after a ceremony to mark the opening of the legal year on Jan. 24, 2022 in Hong Kong. Anthony Kwan/Getty Images hide caption
The Lady Justice statue stands atop the Final Court of Appeal in Hong Kong after a ceremony to mark the opening of the legal year on Jan. 24, 2022 in Hong Kong.
LONDON Britain said Wednesday that it is withdrawing its judges from Hong Kong's top court because keeping them there would legitimize oppression in the former British colony.
British judges have sat on the court since Hong Kong was returned to China in 1997. The British government's move underscores the Asian financial hub's growing isolation as the ruling Chinese Communist Party works to assert its control and silence independent voices.
While the U.K. had judges serving on the Court of Final Appeal as part of efforts to safeguard the rule of law in the city, the British government said it was "no longer tenable" because of increasingly oppressive laws enacted by China. The two senior British judges on the court submitted their resignations with immediate effect Wednesday.
"The courts in Hong Kong continue to be internationally respected for their commitment to the rule of law," U.K. Supreme Court President Robert Reed said after his resignation from the Hong Kong court. "Nevertheless, I have concluded, in agreement with the government, that the judges of the Supreme Court cannot continue to sit in Hong Kong without appearing to endorse an administration which has departed from values of political freedom, and freedom of expression."
Fourteen non-permanent judges remain at the Hong Kong court, including 10 from other common law jurisdictions such as Australia and Canada.
China has intensified its crackdown on Hong Kong's semi-autonomous political and legal institutions in recent years. Those efforts include passage of a sweeping national security law in 2020 and changes to the electoral system that have effectively ended political opposition in the territory.
The security law, which outlaws secession, subversion, terrorism and foreign collusion, has been used to arrest more than 100 pro-democracy figures, and many others have fled abroad. Since the law's introduction, Hong Kong police have raided the offices of pro-democracy media, shutting them down and arresting journalists.
Lawmakers, students and the organizers of candlelit memorials marking Communist Party's deadly 1989 crackdown on a pro-democracy movement have also been targeted.
Some Western governments and the United Nations say the security law is eroding the autonomy promised when the city was transferred back to China under the "one country, two systems" principle.
British Prime Minister Boris Johnson said the two U.K. judges had "concluded that the constraints of the national security law make it impossible for them to continue to serve in the way that they would want."
"I appreciate and I understand their decision," he said.
In announcing the move, British Foreign Secretary Liz Truss said there had been "a systematic erosion of liberty and democracy in Hong Kong."
"The situation has reached a tipping point where it is no longer tenable for British judges to sit on Hong Kong's leading court, and would risk legitimizing oppression," she said.
The decision to pull British judges out after many years in Hong Kong was welcomed by British lawmakers. A senior Conservative Party member of Parliament, Tom Tugendhat, said British judges should not help empower "a legal system that is now being used to lock up Hongkongers without due process."
Conservative lawmaker Iain Duncan Smith, a longtime critic of the government in Beijing, said "the government has done the right thing here, and not a minute too soon."
"What Ukraine teaches us is that you simply cannot appease totalitarian states or make excuses for their behavior, which is exactly what the presence of our judges (was) doing in Hong Kong,'' Duncan Smith said. "They were lending legitimacy to a regime hell-bent on undermining our way of life."
The Hong Kong Bar Association called the decision "a matter of deep regret." It appealed to the Court of Final Appeal's remaining overseas judges to stay and serve the city, and help uphold its judicial independence.
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Britain withdraws its judges from Hong Kong's top court - NPR
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Government parties vote against bill calling for a referendum on Ireland’s neutrality – TheJournal.ie
Posted: at 2:29 am
Updated 10 hours ago
THE GOVERNMENT PARTIES have voted against a private members bill calling for a referendum on Irelands neutrality to be held.
People Before Profit TD Richard Boyd Barrett said his party are seeking a referendum on the insertion of neutrality into the Constitution.
There were 67 votes for the proposal and 53 against, with no abstentions.
Many people believe that Irelands neutrality is protected in the Constitution because there is a long understanding and overwhelming support for the idea that Ireland should be neutral but, in fact, that neutrality is not protected in the Constitution, and we believe it is seriously under attack, he told the Dil earlier today, ahead of the vote.
He said the Government and the wider European political establishment are seeking to exploit the crisis in Ukraine to justify moving towards greater EU militarisation, the establishment of a European army, and closer alignment with NATO.
The Green Party just had the decisive vote on whether we have a referendum to insert neutrality into the Constitution.
They used it to vote against their own policy which Eamon Ryan has voted for three times before in the Dil, supporting the militarists of FFFG.
Shame pic.twitter.com/LKgcS879qj
A betrayal
Irelands neutrality and the struggle for an independent Irish republic are one and the same, they always have been. To move away from Irelands neutrality is not just some sort of interesting tactical or strategic choice. It is in fact a betrayal of the essential struggle to establish an independent republic, he said.
Neutrality does not mean indifference. Neutrality means standing against warmongers and empires and standing with the oppressed. If we throw that away, we will throw away what is the identity that was the struggle for the Irish Republic, and we will do so at our peril. We should not do that and I hope the House will support the Bill, he told the Dil.
TD Paul Murphy hit out at Fine Gaels position on neutrality over the years, telling the Dl that in 2003, Fine Gael proposed a policy document called Beyond Neutrality.
Murphy claims this was a move towards participation in a common EU defence policy and abandoning the so-called triple-lock mechanism.
Let us not kid ourselves that this latest push to fully undermine and get rid of this political straitjacket and to undermine neutrality is a mere pragmatic response to the war in Ukraine, he said.
Murphy said that NATO is being rebranded as some sort of peace force as if it was simply the neutral teacher on the playground stopping the bullies.
Tell that to the ordinary people of Afghanistan whose country was invaded and occupied by NATO for years. Who gave NATO or the US the right to consider themselves the world police? he asked.
The Green Party position
Murphy also questioned the Green Party on its stance, stating that the party leader, Eamon Ryan, has voted to enshrine neutrality in the Constitution on three previous occasions in 2003, 2016 and 2018.
The question of neutrality is very clearly in the Green Party manifesto, he pointed out.
Pictured are protestors, including Sinn Fein's defence spokesperson John Brady, at a demonstration organised by People Before Profit-Solidarity outside Leinster House this evening, calling for Ireland to remain neutral in the Russian Ukraine conflict. Source: Leah Farrell
In response, Foreign Affairs Minister Simon Coveney told the Dil that Irelands neutrality has never stopped us participating in world events nor, self-evidently, from being affected by them.
It does not mean that we are inactive in situations where we see flagrant breaches of the UN charter and clear violations of international law, including international humanitarian law, said the minister.
The Bill would likely to curtail Irelands efforts to contribute to international peace and security, rather than in any way enhance it, said Coveney.
He said the Bill also purports to provide constitutional guarantees that the State shall not allow its territory to be used by other states to transport war material or personnel to third countries for the purpose of war or other armed conflict.
Everyone in this House already knows that foreign state and military aircraft that are permitted to land at Irish airports, including Shannon Airport, must comply with strict conditions. These include routine stipulations that the aircraft must be unarmed, carry no arms, ammunition or explosives, and must not engage in intelligence gathering, said Coveney.
Pull the other one
Yeah, right, replied People Before Profits Mick Barry, before telling the minister to pull the other one.
Labours Brendan Howlin said Ireland should remain neutral and not be aligned to any military pact. However, he said Ireland is enthusiastic to use its vast experience in peacekeeping, peacemaking, humanitarian efforts and in soft international power.
He said Ireland is in a unique position where it is seen internationally as honest brokers that are not involved in armed oppression but there to bring peace, diplomacy and relief to those who are oppressed.
The Government has stated that it is opposing the Bill, calling it unnecessary.
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Irelands policy of military neutrality as practised by successive Governments means that we do not participate in military or common or mutual defence arrangements.
There is no need to insert a Constitutional provision, which could constrain the Governments scope to respond flexibly and effectively in urgent circumstances.
Any discussion of Irelands approach to security and defence should take place in an open and evidence-based way, and at an appropriate time, said a Government spokesperson.
Inserting provisions into the Constitution would close that conversation off.
The provisions seem designed to also preclude contributing to even medical supplies, food rations or protective equipment via the European Peace Facility, to partners such as the African Union or Ukraine.
Wemay well need to have a fresh conversation about our approach to security and defence. This Bill obstructs rather than facilitates such a conversation, which should beopen and evidence-based way, and at an appropriate time, it said.
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The double standard on Russia and Xinjiang –
Posted: at 2:29 am
Salih Hudayar talks to the Taipei Times about the war in Ukraine, its impact on the ongoing genocide in his homeland and how Taiwan can work with his government in exile
By Mark Buckton / Contributing reporter
When Salih Hudayar was born in the small city of Artux, East Turkestan, in May, 1993, the land of his birth had been under Chinese control for 44 years.
A Uighur by birth, Hudayar was just seven years old when he and his family moved to the US in 2000, arriving as political refugees before settling in Oklahoma, where he went to school and eventually joined the US Reserve Officer Training Corps.
Always aware of his background and family heritage, however, in 2017 Hudayar established the East Turkestan National Awakening Movement, and within 12 months was meeting members of the US Congress to promote awareness of Chinas oppression of Uighur people.
Photo courtesy of Salih Hudayar
GENOCIDE IN XINJIANG
His reference to a genocide being carried out against his people in 2018 is now a commonly accepted term for Chinas treatment of millions of predominantly Muslim Uighurs and other Turkic peoples across East Turkestan an area Beijing refers to as Xinjiang.
In late 2019, as an increasingly prominent figure in the push for East Turkestan independence, Hudayar was elected prime minister of his nations government-in-exile, and early last year, the term genocide was echoed by former US secretary of state and recent visitor to Taiwan Mike Pompeo, who said I have determined that the Peoples Republic of China (PRC), under the direction and control of the Chinese Communist Party (CCP), has committed genocide against the predominantly Muslim Uighurs and other ethnic and religious minority groups in Xinjiang.
Photo courtesy of Salih Hudayar
He added that the world is witnessing the systematic attempt to destroy Uighurs by the Chinese party-state.
A few days ago Prime Minister Hudayar, one of the worlds best known faces of the Uighur cause, spoke with the Taipei Times.
Hudayar last year said that world leaders have largely ignored the genocide in East Turkestan, choosing profits over humanity. Have conditions improved? Not much has changed, he says.
Photo courtesy of Salih Hudayar
The Trump Administration formally recognized Chinas atrocities as genocide and this has carried on into the Biden Administration with nations in Europe including the UK, the Netherlands, Lithuania, Czech Republic, Belgium and France formally recognizing the same. However, not much has been done beyond that, Hudayar says.
In recent weeks Russian aggression against Ukraine has taken attention away from the Chinese genocide against the Uighurs.
The US and Western governments, he says, are almost belittling themselves, begging China to step in and apply pressure on Russia.
Chinese leader Xi Jinping () on March 18 told US President Joe Biden that the US must oppose Taiwan independence and not interfere in issues such as Tibet and Xinjiang.
This has had a negative impact on our struggle because the international community no longer seems to be willing to apply pressure on China because of the conflict in Ukraine, Hudayar says.
But, he adds, this isnt about race or religion, a common claim made by the international media. Instead, the free world being more impacted by the actions Russia will take in Ukraine due to geographical location, whereas in East Turkestan, Taiwan and Tibet, were thousands of miles away from Europe or the US.
DOUBLE STANDARD
The world has completely or largely forgotten, given the fact that it is now eight years since China initiated its campaign of genocide and mass internment in East Turkestan, yet you dont see governments doing anything significant to punish China, or to uphold their obligations under the UN Genocide Convention, whereas with the Russian invasion of Ukraine you see this double standard, Hudayar says.
Immediately you have Western governments applying sanctions, hundreds of western companies leaving Russia and governments urging the International Criminal Court (ICC) and International Court of Justice (ICJ) to investigate Russia although no such moves have been made to support the people of East Turkestan, who launched their own ICC case in mid-2020, he adds.
No government has formally stepped up to urge the ICC to investigate Chinese officials for genocide, he says, adding that the international community in this regard are remaining silent.
Hudayar also commented on Taiwans approach to the Uighur and Turkic peoples cause, with Taipei increasingly vocal in its condemnation of the Russian invasion in recent weeks, despite being largely silent on the genocide in East Turkestan.
There have been people in the ruling Democratic Progressive Party (DPP) and other party members who have spoken out against Chinas genocide, but on an official level the government has been relatively quiet, Hudayar says.
He also noted the large number of Chinese Nationalist Party (KMT) supporters in Taiwan who still officially view East Turkestan, Tibet and Mongolia as part of China.
We fully support Taiwanese independence and we support the people of Taiwan, he says. We believe that [Taiwan is] already an independent and free nation. This is something they need to formally step up, and declare, whether there are protests from China or not.
However, we have the same common enemy, he adds. Its crucial that we work together in as many ways as we can to cooperate and give each other mutual recognition and support in any way so we can to stand up against the PRC and the threat of the CCP.
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Psoriasis: More than skin deep – Harvard Health
Posted: at 2:27 am
The first accurate medical discussion of psoriasis dates back to 1801, but the disease itself is much older. In fact, its very name is borrowed from an ancient Greek word meaning an itchy or scaly condition. About 7 million Americans are plagued by this itching and scaling, and many of them have serious complications involving other organs. Although psoriasis is classified as a dermatologic disease, it doesn't start in the skin, and its damage may be more than skin deep.
At a basic level, psoriasis is a disorder of the immune system. White blood cells called T-helper lymphocytes become overactive, producing excess amounts of cytokines, such as tumor necrosis factor, interleukin-2, and interferon-gamma. In turn, these chemicals trigger inflammation in the skin and other organs. In the skin, the inflammation produces three characteristic findings: widened blood vessels, accumulation of white blood cells, and abnormally rapid multiplication of keratinocytes, the main cells in the outer layer of the skin. In healthy skin, keratinocytes take about a month to divide, mature, migrate to the skin surface, and slough off to make way for younger cells. But in psoriasis, the entire process is speeded up to as little as three to five days. The result is thickened, red skin that sheds silvery scales of keratinocytes that have matured before their time (see Figure 1).
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20 Proposals on Methotrexate Dosing in Patients with Psoriasis Discussed – MD Magazine
Posted: at 2:27 am
A consensus was reach on 20 of the 21 proposals regarding dosing of methotrexate in patients with psoriasis, which investigators of the eDelphi study believed could be use to harmonize the treatment of the drug in affected patients.
As one of the 4 available systemic treatments, methotrexate has been prescribed for psoriasis for over 6 decades, and is also used prominently in the rheumatology field.
However, methotrexate was approved by the US Food and Drug Administration before the introduction of dose ranging studies. As such, a clear dosing regimen for the treatment is lacking.
As such, investigators led by Astrid van Huizen, MD, Department of Dermatology at the University of Amsterdam, conducted the eDelphi study to reach international consensus on the dosing of methotrexate for treating patients with psoriatic disease.
The study consisted of 3 sequential survey rounds that were conducted in September 2020, November 2020, and February 2021. An online consensus meeting occurred following the last survey round in June 2021.
A total of 4500 members of the Skin Inflammation and Psoriasis International Network (SPIN) were invited to participate. Additional emails were sent to 108 national representatives and 35 scientific committee members of the network.
From September 2020 to March 2021, a total of 180 participants worldwide- 30.6% of whom resided in non-Western countries- completed the 3 survey rounds.
Participants voted on 21 individuals proposals on a 9-point scale, 1-3 indicated disagree, 4-6 neither agree nor disagree, and 7-9 being agree.
A majority of participants worked at a university hospital (53.9%) and were experienced in treating patients with psoriasis with methotrexate (91.6%), with more than 10 years of experience.
Among the 251 participants included in the study, 180 (71.7%) completed all 3 survey rounds, and 58 participants (23.1%) joined the conference meeting.
No consensus was achieved regarding increased dosage of folic acid when increasing the dosage of methotrexate, with members of the study citing a lack of conclusive evidence.
However, a consensus was met regarding children and methotrexate dosing, though most proposals were based on studies from rheumatology due to a lack of evidence in dermatology.
The most widely discussed proposals involved patients with frailty. Elderly individuals, individuals with kidney renal dysfunction, liver disorders (eg, nonalcoholic steatohepatitis), ulcerative colitis, history of hepatitis, lack of compliance, gastritis, diabetes, previous cancer, and congestive heart failure were included in the added definition of patients with frailty.
Furthermore, the term patients with frailty was replaced with vulnerable patient, which excluded elderly patients and patients with impaired kidney function.
While a consensus was achieved in the study, investigators believed that additional high-quality studies were needed to support the proposals offered by the group.
Other consensus projects can focus on the screening and monitoring of this drug, how often and which tests should be performed, and whether special precautions are needed in children, elderly individuals, and other subpopulations, the team wrote.
The statement, "International eDelphi Study to Reach Consensus on the Methotrexate Dosing Regimen in Patients With Psoriasis," was published online in JAMA Dermatology.
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20 Proposals on Methotrexate Dosing in Patients with Psoriasis Discussed - MD Magazine
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Dr Pimple Popper changed 9-year-old Yaelles life forever with genius treatment – Reality Titbit – Celebrity TV News
Posted: at 2:27 am
Who remembers the sweet 9-year-old girl, Yaelle from Dr Pimple Popper? Yaelle was featured on Season 5 during the episode entitled, Cyster Cyster and quickly captivated fans attention with her bubbly and charismatic personality. Unfortunately, she suffered from a serious case of psoriasis that covered her entire body and she went on the show in hope that Sandra Lee could help her.
The epic episode contained many bizarre situations including the twin sisters that both had cysts, however, Yaelle was the stand out star of the show and fans want to know what happened to her and if she managed to get her psoriasis sorted. Keep reading to find out!
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Yaelle is from a town called Hotchkiss in Colorado and at just nine years old she had suffered from extreme psoriasis all the way from her arms, neck, legs and head from a very young age and her condition was so bad that she said the skin often clogged up her ears.
The little girl had suffered from the condition since she was a baby, however, it started off only around her eyes and belly button but when she was nine it quickly flared up across her entire body.
Heartbreakingly, Yaelle opened up about how embarrassed she was by her condition and how she would style her hair specifically to try and cover it on her face. Her mom had tried to get her medications and steroids but none of them worked and only seemed to make it worse, so they finally decided to see Dr Lee in hopes of a miracle.
They drove all the way from Colorado to California to see the pimple popper and its safe to say it was worth the trip.
During the consultation, Lee described the many treatment options that were available for Yaelles condition but explained how most are too intense and dangerous.
However, we all know how amazing Dr Lee is and she obviously had a plan. The family had only been used to more old-fashioned treatment methods but Lee was here to introduce them to some new ones.
Dr Lee explained an amazing new medication that was only required to be taken once every three months by injection and said the results are usually spectacular. Yaelle was quick to jump at the opportunity and was very brave while receiving the injection.
At the end of the episode, we got to see Yaelle a few months later and fans were gobsmacked. The transformation was incredible and her psoriasis was almost cleared. Yaelle was over the moon and said she finally felt like me again.
During the episode we heard the pain Yaelles mother was going through from having to see her daughter suffer so much, she opened up about the familys Jewish religion and how they strive to live a self-sustaining, off-grid lifestyle.
The only issue with this was that the mom said it affected her daughter due to them being so far away from most towns it was hard for them to get doctors out and treat her psoriasis.
The family grow their own food and products and Yaelle was clear about how much she loves the outdoors so we are over the moon that she can finally enjoy it to its fullest!
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Niamh is a multi-faceted journalist with speciality interests in entertainment, lifestyle and culture. She recently graduated from the University of South Wales with a degree in Journalism and enjoys writing features, reviews and trending news stories.
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Dr Pimple Popper changed 9-year-old Yaelles life forever with genius treatment - Reality Titbit - Celebrity TV News
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Global Psoriatic Arthritis Treatment Market to be Driven by Rising Incidence of Psoriatic Arthritis and Extreme Symptoms in the Forecast Period of…
Posted: at 2:27 am
The new report by Expert Market Research titled, GlobalPsoriatic Arthritis Treatment MarketReport and Forecast 2021-2026, gives an in-depth analysis global psoriatic arthritis treatment market, assessing the market based on drug class, product type, route of administration, and major regions. The report tracks the latest trends in the industry and studies their impact on the overall market. It also assesses the market dynamics, covering the key demand and price indicators, along with analysing the market based on the SWOT and Porters Five Forces models.
Request a free sample copy in PDF or view the report summary@https://www.expertmarketresearch.com/reports/psoriatic-arthritis-treatment-market/requestsample
The key highlights of the report include:
Market Overview (2016-2026)
In addition to the rise in biological and biosimilar therapies, there is an increase in the prevalence of psoriatic arthritis and an increase in R&D activities to develop novel drugs for the treatment of psoriatic arthritis. There is also an increase in demand for psoriatic arthritis treatment goods, along with an increase in the elderly population. High treatment costs and a lack of standardised diagnostic technologies, on the other hand, are projected to restrain market expansion.
Industry Definition and Major Segments
Psoriatic arthritis is a spondylarthritis-related inflammatory joint disease caused by psoriasis. Skin and musculoskeletal systems are both affected. Genetics and the environment both play a role in its development. Psoriatic arthritis symptoms include swollen toes, fingers, and joints, and pitted nails and discomfort.
Explore the full report with the table of contents@https://www.expertmarketresearch.com/reports/psoriatic-arthritis-treatment-market
On the basis of its drug class, the market can be widely categorised as:
Based on its product type, the market can be bifurcated as:
The different administration route available for psoriatic arthritis treatment are:
The regional markets for the product include North America, Europe, the Asia Pacific, Latin America, and the Middle East and Africa.
Market Trends
More than half of the revenue share was captured by biologics in the Psoriatic Arthritis (PsA) Treatment market. The drug class is likely to increase at the fastest rate during the forecast period and maintain its dominance. The segments growth is expected to be bolstered by the good commercial performances of existing products and the upcoming releases of potential pipeline prospects.
North America and Europe accounted for over half of total revenue. North America led the regional markets, mostly due to product sales in the United States. There is also a substantial patient pool and significant manufacturers supporting the PsA treatment market expansion. Asia Pacific is predicted to be one of the fastest expanding areas. Biosimilars are a crucial growth driver in emerging economies including China, India, and South Korea. Regional expansion is also likely to be influenced by overall economic development, healthcare infrastructure improvements, rising disposable income, and consumer awareness.
Key Market Players
The major players in the market are AbbVie Inc., Amgen, Inc., Johnson & Johnson Services, Inc., Bristol-Myers Squibb Company, Celgene Corporation, Novartis International AG, Eli Lilly and Company, Pfizer, Inc., UCB S.A, and AstraZeneca plc, among others. The report covers the market shares, capacities, expansions, investments and mergers and acquisitions, among other latest developments of these market players.
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Upadacitinib Improves Pain Associated with Ankylosing Spondylitis, PsA – MD Magazine
Posted: at 2:27 am
Upadacitinib has already been found to be safe and effective in the phase 3 SELECT-PsA 1 and 2 studies on patients with active psoriatic arthritis (PsA), as well as among patients with active ankylosing spondylitis (AS) in the phase 2/3 SELECT-ASXIS 1 study.
However, a new investigation compiled the data from all 3 randomized trials which brought more insight on upadacitinib's effect. Patients with active psoriatic arthritis or ankylosing spondylitis displayed rapid and sustained improvements in pain outcomes with upadacitinib for over a year.
The population included patients who have experienced either inadequate responses to non-biologic or biologic disease-modifying antirheumatic drugs (DMARDs), or were biologic-naive with inadequate response to non-steroidal anti-inflammatory drugs. Improvements were consistent and observed across several endpoints.
In all 3 studies, patients were randomized to receive either upadacitinib 15 mg once daily, or placebo. In SELECT-PsA 1, an additional group was administered adalimumab 40 mg every other week. Investigators, led by Iain B McInnes, MD, PhD, University of Glasgow, College of Medical, Veterinary and Life Sciences, evaluated pain outcomes based on increments.
In post hoc analyses, when compared with baseline, outcomes were measured by the proportion of patients who achieved 30%, 50% and 70% reduction using a patient global assessment of pain.
Also, changes from baseline were assessed at specific time points, as were particular questions from Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Additional end points that were unique to each study were looked at.
The research showed that a higher proportion of patients who received upadacitinib acheived 30%, 50% and 70% reduction in pain end points compared with placebo.
The improvements were observed as early as week 2 and were sustained or further increased through the first year (PsA 1/2 studies: 64%/48%, 58%/42% and 38%/22%, respectively; SELECT-AXIS 1 study: 76%, 72% and 54%). The data regarding adalimumab from the SELECT-PsA 1 study produced similar results (59%, 49% and 32%).
Patients who switched from placebo to upadacitinib 15 mg were able to improve to similar levels of the continuous upadacitinib group by the end of year 1 (PsA 1/2 studies: 46%60%, 35%49% and 15%34%; AS study: 83%, 72% and 46%).
Investigators pointed to the importance of pain management in these populations a key component to the treatment of psoriatic arthritis and ankylosing spondylitis. Pain has an incredible impact on an individual's quality of life, fatigue, and functional work impairment.
The study "Effect of upadacitinib on reducing pain in patients with active psoriatic arthritis or ankylosing spondylitis: post hoc analysis of three randomised clinical trials" was published in RMD Open Rheumatic & Musculoskeletal Diseases.
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Upadacitinib Improves Pain Associated with Ankylosing Spondylitis, PsA - MD Magazine
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Musk Factor Studios goes for the Holy Grail in TEMPLARS CODE – Verve Times
Posted: at 2:27 am
The Small Press Spotlight is going to Mars this week thanks to Musk Factor Studios. The publisher has launched a Kickstarter campaign for its first epic comic Templars Code. Described as a comic book about an engineer in a Mars colony who finds the Holy Grail, which lets him travel back in time to help Nikola Tesla, the original title is action-packed with time travel, mystical elements, science fiction, and of course the Knights Templar.
Written by Rafael Tadevosyan, the comic is part of the Musk Factor Universe and a spinoff of the Musk Factor series, a satirical sci-fi comedy about a tech startup. Andranik Asatryan leads the art team, using his range of artistic styles to bring out the tale. Ani Avetisyan is the illustrator and inker, while Alex Mikaelyan takes on letters.
Deemed a Project We Love by Kickstarter, the comic is described as an explosive original comic book filled with mystical adventures, time-travel, and everyones favorite order of chivalry: The Knights Templar. Set in the Mars colonization era, it is a literal out-of-this-world adventure comic that follows Tom, a pioneering engineer employed by a Martian Colony. On Mars, Tom stumbles upon the Holy Grail and with it, travels back in time to help Nicola Tesla prevent many of the catastrophic events of the twentieth century.
Mars is a new world for humans; its a tantalizing place of mystery and intrigue. The masses believe that Mars is none but a barren wastelandan empty planet perpetuated by heat, violent winds, and infinite deserts. But Tom, ardent with faith, soon unmasks secrets hidden beneath the sandy dunes of Mars. In doing so, Tom may be able to prove that this seemingly lifeless planet, is in fact, the very core of paramount events that span across time itself.To back Templars Code, click here! Watch a trailer for the series below!
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Musk Factor Studios goes for the Holy Grail in TEMPLARS CODE - Verve Times
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