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Monthly Archives: March 2022
Pelicans star Zion Williamson cleared to progress in basketball activities: Sources – The Athletic
Posted: March 11, 2022 at 12:22 pm
New Orleans Pelicans star Zion Williamson is returning to New Orleans after spending time in Portland for his foot rehab and is cleared to progress in basketball activities, sources tell The Athletic.
This update comes after the Pelicans announced Wednesday that imaging on Williamson's right foot showed improved bone healing and that he would gradually progress to full weight-bearing exercise and basketball activities. They added the power forward still remains out indefinitely.
Williamson, 21, has been recovering from surgery for a fractured foot suffered prior to summer league, Pelicans vice president of basketball operations David Griffin has previously stated. Williamson hasn't yet played a game during the 2021-22 NBA season and has suffered setbacks during his rehabbing progress.
The one-time All-Star has played just 85 NBA games since being drafted the 2019 No. 1 pick. Williamson boasts averages of 25.7 points, seven rebounds and 3.2 assists on 60.4 percent shooting from the field.
New Orleans (27-36) has won four in a row, currently sitting at 10th in the Western Conference and eyeing the Play-In tournament.
(Photo: Layne Murdoch Jr. / NBAE via Getty Images)
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JEE Main 2022 registration; Things to keep in mind while applying – Careers360
Posted: at 12:20 pm
The National Testing Agency (NTA) will close the JEE Main 2022 registration on March 31. Things to keep in mind before filling out the application form. Check here.
New Delhi: The National Testing Agency (NTA) has started the JEE Main 2022 registration from March 1. Candidates are advised to start with the JEE Main 2022 registration process as it will end on March 31, 2022. As expected, the NTA will release separate JEE Main 2022 application forms for both the April and May sessions. Candidates can visit the official website to fill out the JEE Main application form 2022 http://www.jeemain.nta.nic.in.
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There are certain steps that a candidate must go through in order to apply for the JEE Main 2022 like filling out the application form, uploading a scanned passport-sized photograph, scanned signature, and fee payment. Candidates are advised to complete the registration process within the JEE Main 2022 application form date in order to appear in the exam.
Candidates should go through all the information mentioned down below in order to know more about the JEE Main 2022 registration.
Candidates are advised to go through all the details about the schedule of the JEE Main 2022 application form for all sessions so as not to miss any event of registration.
Events
Session 1 - April
Session 2 - May
JEE Main 2022 application form releasing date
March 1, 2022
April 8, 2022
Last Date to apply for JEE Main 2022
March 31, 2022
May 3, 2022
JEE Main 2022 application form correction date
Not applicable
Not applicable
JEE Main 2022 exam date
April 16 to 21, 2022
May 24 to 29, 2022
Candidates are advised to fill out the JEE Mains application form carefully as the authorities have not given the correction facility this year.
Make sure all the details are authentic as the IIT JEE application form can be rejected anytime if found faulty.
The scanned images of the passport-sized photographs and signatures must be of the specified format.
Remember to take a printout at the end after completing the application form of JEE Main.
Visit the JEE Main 2022 official website http://www.jeemain.nta.nic.in.
Enter the necessary details like name, mobile number, and email ID while applying for the JEE Main registration 2022.
Fill out the JEE Main application form 2022 with personal and educational details.
In the next step, candidates need to upload their scanned passport-sized photograph along with their scanned signature.
After submitting all the required details, candidates will land on a new page.
Now, candidates have to pay the online JEE application form fee.
Once, the payment is made, candidates must download the JEE Main 2022 confirmation page for future reference.
Candidates need to carry certain documents at the time of JEE Main registration 2022. Here is a complete list of all the essential documents that will be required to fill JEE Main 2022 application form.
Class 10th certificate and Class 12th certificate (if passed).
Scanned passport-sized photograph and signature.
EWS (Economically Weaker Section) certificate (necessary for those candidates belonging to the EWS category).
PwD certificate (if candidates belong to the disability reservation category).
Internet banking or credit/debit card details at the time of fee payment.
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Aer Lingus Restarts Flights from Shannon to the US – RusTourismNews
Posted: at 12:20 pm
Aer Lingus has today restarted its transatlantic services from Shannon, reconnecting the mid-west of Ireland with the US.
From today, 10th of March, daily flights to Boston resume with flights to New York making a comeback from tomorrow, Friday 11th March.
These are the latest transatlantic routes from Aer Lingus to resume since the lifting of travel restrictions to the US and marks the first transatlantic flight between Shannon airport and the US since March 2020. The restart of these flights is critical in restoring regional connectivity and Aer Lingus is the only airline flying to Boston and New York -JFK this summer, with 14 flights a week from Shannon to the US.
Summer 2022 will see Aer Lingus fly its largest transatlantic seat capacity from Shannon in 17 years as it operates two next generation A321 NEO LR aircraft from the airport. The state-of-the-art aircraft promise a more innovative and sustainable travel experience, boasting greater fuel-efficiency, with a 15% reduction in fuel burn, compared to a A321CEO and a 50% reduction in noise footprint compared to previous generation aircraft. Offering both a Business Class cabin with 16 fully lie-flat seats, fine dining and complimentary wi-fi, and an Economy Class cabin with complimentary meal and snack and soft drink in-flight, and top inflight entertainment, including the latest movie releases, TV boxsets, games and music.
Aer Lingus will operate 14 direct routes between Ireland and North America in 2022, including New York, Miami, Chicago, Boston, Los Angeles, San Francisco, Orlando, Washington, Seattle, and Philadelphia.
Speaking on the route restart, Donal Moriarty, Chief Corporate Affairs Officer at Aer Lingus said:
We are delighted to resume our transatlantic routes from Shannon to Boston and New York, restoring regional connectivity to the mid-west of Ireland and allowing Aer Lingus to unite friends, families, and businesses once more.
This summer we will be operating our largest transatlantic seat capacity from Shannon in 17 years. Aer Lingus customers will avail of a more innovative and sustainable travel experience as they travel across the Atlantic in our two A321LR neo which will operate from Shannon airport and our unique warm Aer Lingus welcome.
As always, customers flying to North America with Aer Lingus will enjoy complimentary meals and drinks, endless hours of in-flight entertainment, WiFi on board and US Customs and Border pre-clearance at Shannon airport.
Mary Considine, CEO of Shannon Group said: The links between the US and the West of Ireland are a huge part of Shannons story. We are delighted to be here today to mark another milestone in the airports recovery with the re-establishment of crucial US air links that were suspended as a result of the pandemic.
It is a fantastic day for our passengers, our staff, the broader airport community and the US Customs and Border Protection team here at Shannon Airport. The restoration of these daily vital U.S. services will be a welcome boost for the West of Ireland economy, and will see friends, family and business communities reconnected.
In order to make travel easier when travelling to the United States, Aer Lingus has partnered with VeriFLY. By downloading the VeriFLY app and uploading Covid-19 related documentation required for their destination, Aer Lingus transatlantic customers can ensure that all their Covid-19 related documentation is verified before travel.
Aer Lingus market-leading Book with Confidence policy* allows customers to change flights as many times as they like, should plans change, giving customers peace of mind when booking.
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Aer Lingus Restarts Flights from Shannon to the US - RusTourismNews
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Why Is CF Industries (CF) Stock Up Today? – InvestorPlace
Posted: at 12:19 pm
Agricultural company CF Industries (NYSE:CF) had a strong performance today on news that Russia will suspend exports of fertilizers. Specifically, CF stock saw a 5% jump on the news, just the latest in a string of promising trading days for the company.
Source: Fotokostic / Shutterstock.com
Whats going on with CF lately?
Well, earlier today, the Russian Industry Minister announced a decision to temporarily cease fertilizer exports in order to combat higher food prices in the country. Russia produces 14% of urea in the world and meets 21% of potash global demand, both important inputs for fertilizer.
As you might imagine, CF stock investors were pleased by this news. U.S. fertilizer makers will likely have a production advantage compared to much of Europe and Asia. This is largely attributable to cheaper natural gas than its global counterparts.
With prospects on the stock having steadily risen in recent quarters, todays news is likely icing on the cake. So, what else do you need to know about CF Industries?
Since the start of Russias invasion of Ukraine, CF stock has been in focus. Whats more, the company has reported strong earnings numbers quarter after quarter. In its latest fourth-quarter earnings call, CFs gross margin increased from 16.3% to 45.5% year-over-year (YOY).
Many suspect that Russias invasion of Ukraine will put even more upward pricing pressure on ammonia-based fertilizers, putting companies like CF in the spotlight. The raw materials necessary to make fertilizers typically require large amounts of natural gas. So, companies with a competitive advantage in that space are currently promising.
CF stock joins a number of fertilizer names making gains lately. Mosaic (NYSE:MOS) and Corteva (NYSE:CTVA) are also up more than 7% and 4% respectively today.
Since September, CF has more than doubled its stock price, from around $46 then to $97 per share today. Now, many investors believe its poised to continue making strong gains given the current geopolitical climate.
On the date of publication, Shrey Dua did not hold (either directly or indirectly) any positions in the securities mentioned in this article. The opinions expressed in this article are those of the writer, subject to the InvestorPlace.comPublishing Guidelines.
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Walford, Englands Sam Patterson is the future of MMA: BRAVE CF president Mohammed Shahid – CONAN Daily
Posted: at 12:19 pm
Sam The Future Patterson, 25, of Walford, England, United Kingdom is currently in Bahrain. He is set to fight Khunkar-Pasha Osmaev, 31, of Grozny, Chechnya, Russia at BRAVE CF 57, the first BRAVE Combat Federation event in 2022.
Featuring 12 professional mixed martial arts bouts and one amateur MMA fight, BRAVE CF 57 will be held at the Khalifa Sports City Arena in Isa Town, Bahrain on March 11, 2022. In the eighth bout of the evening, Patterson and Osmaev will battle it out in the lightweight division.
Fighting professionally since 2017, Patterson joined BRAVE CF in 2019. On November 6, 2021, he earned his fourth win in the promotion by submitting Kamil Magomedov of Moscow, Russia via guillotine choke at BRAVE CF 55 in Rostov-on-don, Russia.
BRAVE CF president Mohammed The Hawk Shahid was very impressed by Pattersons performance that night. The victory improved the Walford natives professional MMA record to 8 wins, 1 loss and 1 draw.
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Sam Patterson is indeed the future of this sport, Shahid said. Its not just his moniker (but also) because he embodies every sense of the word. Look at his magnificent performance. It left us wanting more.
Im excited to see what the future holds for The Future, the BRAVE CF president said of Patterson. With him being around, it just makes the promotions stacked lightweight division more interesting.
A total of 16 countries are represented at BRAVE CF 47. These are Afghanistan, Algeria, Azerbaijan, Bahrain, Brazil, Canada, Egypt, England, Georgia, India, Kazakhstan, Kyrgyzstan, Lebanon, Russia, Switzerland and Uzbekistan.
Patterson solely represents England. Osmaev, Kamil Magomedov and Magomed Idrisov represent Russia.
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BRAVE CF 57 is part of the BRAVE International Fight Week 2022, which is being held under the patronage of His Highness ShaikhKhalid bin Hamad Al Khalifa. TheMMA Super Cup2022 is also part of the combat sports event organized byBRAVE CF in cooperation with the International Mixed Martial Arts Federation (IMMAF) and theKhalid Bin Hamad Sports Organization(KHK SPORTS).
In the main event of BRAVE CF 57,Hamza The Pride of Bahrain Kooheji, 29, of Bahrain andBrad Superman Katona, 30, of Canada will compete for the BRAVE CF Bantamweight World Championship. Here is a recent interview with the latter:
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Shane Warne’s charisma, sorcery and hedonism transcended cricket and landed him in the gossip pages – The Telegraph
Posted: at 12:18 pm
I once had a glimpse of this bulletproof image up close. It was 2006, and while his stock in England had never been higher in the wake of the previous summers Ashes, he still carried the notoriety of an earlier phone-sex scandal, in which he had left several lewd messages on the answering machine of a British nurse while married. Before I was due to interview him at a London brokerage, a few traders asked if he could man the switchboard for a photo op. Sure, boys, he grinned, that glint in his eye. Ive always been pretty good on the phone. You could have heard the roar of laddish acclaim the other side of Canary Wharf.
Warne was fortified not just by his genius as a cricketer but by his irresistible charisma. While many men wanted to be just like him, his legions of female admirers were often left helplessly in his thrall. During a 2001 one-dayer in Bangalore, an insistent noise could be heard from the Ladies Stand at the M Chinnaswamy Stadium. Shane Warne, Shane Warne, the women were chanting. You are a big flirt. They then broke into a Hindi love song, The Heart Is Very Indian. At this point he spun around, flashed that roguish smile and blew them three flamboyant air kisses. Warnes untouchable reputation was sealed.
His priceless value to his sport lay in how he even won over people who did not normally like cricket. This is a man who, despite cultivating the type of bonzer bloke image promoted by Castlemaine adverts, still managed to seduce the siren of London high society, Elizabeth Hurley. Even after the pair split after three years together and a brief engagement, Warne could not help but marvel at the incongruity of it all. Everyone thought, Whos this knockabout Aussie with this posh English rose? he reflected. To his critics, it was this chapter that brought an unhealthy fixation with body image. Warne, for his part, always claimed that the relationship changed him in more subtle ways, leading him away from his pursuit of instant gratification.
Right through to the devastatingly premature end, he could be confounding and complex, but always a figure of electrifying charm. For 15 years, he bestrode international cricket, and for the next 15 he only added to his mystique through a life of compelling extremes. His peers were correct: for as long as he was around, it was, in every sense, Warnes world.
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Contemporary Labels Mine the ’90s and Their Own Playbooks at Paris Fashion Week – WWD
Posted: at 12:18 pm
PARIS As physical runways return, so does the street-style set, and with them, a sense of whats to come on the contemporary label scene.
With 90s inspirations galore and the logo still going strong, itll be a season of plenty where brands compete for the attention of consumers keen to dip their toes into trends.
For the Sandro woman, temperatures might take a dive but the heat will be dialed right up, as she heads back to the heyday of the Paris club scene, with a wardrobe fit to go to the original incarnations of the Palace and Bains-Douches hotspots full of jewel tones and flirty numbers.
Never one to be locked into a particular decade, the midriff baring will slide toward the early 2000s for a chic hedonist clubbing spiel, with Britney Spears as a muse. The Parisian labels studio also twisted bourgeois codes and the yuppy wardrobe of the Sandro man of the season imagining the citys girls pairing their preppy cardigans with threads nodding to whichever musical hedonism the Sandro woman is into.
On offer are patchwork denims, fringed blanket jackets, shearling with geometric prints and T-shirts proclaiming hippies were right.
Faith Connexion longed for a post-pandemic sense of renewal and landed on big branding. The Gothic script from its launch in 2000 was resurrected for this collection, blown up and scrawled across slim tweed suits, mini bomber jackets and baggy jeans. Founder Maria Buccellati called the visibility from having the name front-and-center empowerment for the brand.
The collection pushes to new volumes in its silhouettes and pulls its references from everywhere; no era is left untouched. From the 50s in slim suits, a Lurex disco dress recalled the 70s and the oversized hip-hop cargo fit and grunge flannels of the early Aughts all are reinterpreted here for the cool kids.
Nothing is too much. Its like bling but with French flair and very elegant, she said. Reuse became a touchstone for sustainability. Old collections were upcylced into new wares, and suede jackets are reversible for leading a double life. In another first, the brand also launched shoes, a sky-high platform boot in leather and leopard print with plans for more to come.
At Maje, artistic director Judith Milgrom wanted to return to the roots of the label, so Parisian sexiness will be the name of the game. Think Vogue circa 1988, remixing bourgeois lady-like options with youthful codes like denim then and now athleisure, and the mix of menswear-inspired coats and puffers.
Lengths are therefore abbreviated on tops and bottoms, showing legs or midriffs, and asymmetric cutouts played into the tropes of the big houses. No-brainer staples were in the mix, too, like oversize coats and todays ubiquitous puffers.
Fuzzy cardigans with contrasting and golden buttons, paired with a miniskirt for prim-and-proper brunch, or bejeweled jeans and a crop top for a day on the town were some of the loos shown around a bottle green kiosk similar to the very-Paris gazebos in public gardens or newsstands.
Accessories werent forgotten, with flap bags and chunky footwear galore hitting the right balance between cool and practical.
The end result looked like a snapshot of cool Parisian influencers one part major labels, one part vintage finds and a dash of whatevers trending right now at an easy-to-love price point.
Also mining their identity as purveyors of accessible French understated chic was Longchamp, where creative director Sophie Delafontaine looked at what a proper Gallic winter break means: physical activities and an aprs-ski spread.
What the Longchamp woman is packing will sound unseasonably light at first glance, going from little blousons, old-fashioned tweed jackets, skinny-rib sweaters or even long pleated dresses. But layering was the name of the fall game, with a color palette that paired bold oranges and blues of sports gear with winter warm tones inspired by the work of French designer Charlotte Perriand.
Footwear also played on city girl in the snow trope, with snow boots augmented with colorful nylon poofing up to the knee. They added a welcome playful note to a well-built classic wardrobe.
Beyond the seasonal lineup, the preeminence of the racehorse, reworked into a camouflage print, motifs used on quilted outerwear, outlined in sneakers soles or used for chunky metal hardware on the seasons bags nodded to the overarching idea that drove contemporary brands this season an affirmation of brand signatures as a way to identify who their consumers are.
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Contemporary Labels Mine the '90s and Their Own Playbooks at Paris Fashion Week - WWD
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Why the pursuit of happiness can be bad for you – and what you should pursue instead – News24
Posted: at 12:18 pm
Happiness is one of the most important goals in life. During the pandemic, it trended as the most searched word on Google. But heres why the pursuit of happiness can be bad for you.
It can make us more self-centred. The active pursuit of happiness can exacerbate individualistic tendencies to seek out pleasures at the expense of others (breaking up a friendship because it is not fun), society (driving fast may make you happy, but it endangers peoples lives) or the environment (keeping the air-conditioning on overnight).
Ironically, that self-centredness, apart from not serving others well, also makes people who pursue happiness more lonely. Focused on making ourselves happy, we forget the basic principle of happiness, which is to look outside ourselves for true happiness.
Those who score the highest in any happiness rankings report good social support (for instance, supporting others when in need and in return being offered support), live meaningful lives that allow them to contribute to society (put effort into developing skills that serve others well), experience abundance of positive emotions which are often created in the company of others (we smile 30 times more often in a group than in solitude).
This is the irony of the single-minded pursuit of happiness. Focusing on ourselves and wanting to be happier reduces our chances of experiencing happiness.
It can make us realise that were unhappy. The idea that we should be searching for it can highlight the absence of happiness in our lives. The more we value happiness, the more likely it is that we will be disappointed with our current situations.
Even worse, the more desperate we become about finding happiness, the more likely we are to experience symptoms of depression.
It can make us blame ourselves for being unhappy. The implication that we should all be happy and that it is easy to achieve can make us feel like there is something wrong with those who are not happy, causing further distress.
Our obsession with happiness has spawned an industry of people and organisations promising quick-fix ways to make us happy. This is just one of the reasons why the narrow focus on happiness can be damaging.
Apart from happiness not being good for the pursuers, it is often inappropriate to talk about happiness when interacting with people suffering extreme poverty, experiencing political injustice, living through devastating conflicts or facing natural disasters. To put it simply, being happy is not a priority in these situations.
Advocating for initiatives to increase happiness can lead to people feeling alienated and misunderstood. In traumatic times, exhorting people to be happy can come across as tone deaf or lacking in compassion.
If we focus too narrowly on the pursuit of happiness, we are at risk of forgetting about wellbeing, which runs deeper than simple hedonism and includes connections with people, life purpose, a sense of accomplishment and self-worth.
Here are five ways to improve your wellbeing:
Ensure that you can meet the basic needs of yourself and those you care for.
Allocate regular time for pleasurable activities, such as a walk, playing a game or watching or listening to something you enjoy.
Invest in building and maintaining positive relationships. Meet with friends, keep in contact with family members, nurture your work relationships.
Stay connected with what makes your life meaningful. For example, supporting a movement, following a faith or committing fully to your personal or professional role.
Make things better for your community by, say, advocating for better services, volunteering in your community, or challenging unfair practices.
Christian van Nieuwerburgh, Professor of Coaching and Positive Psychology, RCSI University of Medicine and Health Sciencesand Jolanta Burke, Senior Lecturer, Centre for Positive Psychology and Health, RCSI University of Medicine and Health Sciences
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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Why the pursuit of happiness can be bad for you - and what you should pursue instead - News24
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Gene Therapy Potentially Curative for -Thalassemia – Consumer Health News | HealthDay – HealthDay News
Posted: at 12:16 pm
FRIDAY, March 11, 2022 (HealthDay News) -- A one-time infusion of betibeglogene autotemcel (beti-cel) gene therapy yields high levels of transfusion independence in children and adults with transfusion-dependent -thalassemia and a non-0/0 genotype, according to a study published in the Feb. 3 issue of the New England Journal of Medicine.
Franco Locatelli, M.D., Ph.D., from the University of Rome, and colleagues conducted an open-label phase 3 study to examine the efficacy and safety of beti-cel in adult and pediatric populations with transfusion-dependent -thalassemia and a non-0/0 genotype. Twenty-three patients were enrolled, underwent myeloablation with busulfan, and then received intravenous beti-cel. Patients were followed for a median of 29.5 months.
The researchers found that 20 of the 22 patients (91 percent) who could be evaluated had transfusion independence, including six of seven (86 percent) who were younger than 12 years. During transfusion independence, the average hemoglobin level was 11.7 g/dL. In patients with transfusion independence, the median level of gene therapy-derived adult hemoglobin with a T87Q amino acid substitution was 8.7 g/dL at 12 months after beti-cel infusion. Four patients had at least one adverse event considered to be related or possibly related to beti-cel; all except one were nonserious. There were no cases of cancer.
"These data suggest that in most patients with transfusion-dependent -thalassemia and a non-0/0 genotype, one-time infusion of beti-cel is potentially curative through transfusion independence and the attainment of near normal hemoglobin levels," the authors write.
Several authors disclosed financial ties to biopharmaceutical companies, including Bluebird Bio, which funded the study.
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Research Roundup: Genetic Variants Associated with Severe COVID-19 and More – BioSpace
Posted: at 12:16 pm
Specific comorbidities and conditions have been associated with severe COVID-19, including diabetes, obesity, and, of course, older age. But researchers have now identified 16 new genetic variants associated with severe COVID-19. For that and more research stories, continue reading.
16 Genetic Variants Associated with Severe COVID-19
Investigators with theUniversity of Edinburghanalyzedthe genomes of 57,000 people, part of the GenOMICC consortium, a global collaboration to study genetics in critical diseases. They identified 16 new genetic variants associated with severe COVID-19 and sequenced the genomes of 7,491 patients from 224 intensive care units in the U.K. That DNA was compared with 48,400 other people who did not have COVID-19. They were participants inGenomics Englands 100,000 Genomes Project and another 1,630 people who had mild COVID-19. The findings are published inNature.
Our latest findings point to specific molecular targets in critical COVID-19, said Professor Kenneth Baillie, the projects chief investigator and a Consultant in Critical Care Medicine at the University of Edinburgh. These results explain why some people develop life-threatening COVID-19, while others get no symptoms at all. But more importantly, this gives us a deep understanding of the process of disease and is a big step forward in finding more effective treatments.
In addition to the 16 new gene variations, they confirmed seven other genetic variations that were already linked with severe COVID-19. Part of their findings was a single gene variant that can disrupt interferon alpha-10, a key messenger molecule in immune system signaling. This variant alone was enough to increase a patients severe disease risk. Another variation is Factor 8, which is important to blood clotting, and was connected to critical COVID-19.
Nanoparticle decreases Scleroderma Skin and Lung Scarring
Researchers withMichigan Medicine University of Michiganidentifieda unique macrophage, a type of immune cell, that plays a significant role in the chronic inflammation and scarring seen in the lungs and skin of scleroderma patients. The macrophage, dubbed MARCO+, was isolated in people with the disease, which is rare and affects about 70,000 people in the U.S. They then, working with laboratory mice, injected the animals with biodegradable PLG (lactic-co-glycolic acid) nanoparticles that targeted MARCO+ inflammatory cells. This appeared to prevent the skin and lung fibrosis in the mice associated with the disease. The team theorizes that the MARCO+ cells are activated in scleroderma, circulate in the bloodstream, move to tissues, and cause scar formation.
A Predictive Model for Rheumatoid Arthritis
Scientists fromTokyo Medical and Dental Universitydevelopeda genomic model to predict the progression of rheumatoid arthritis. They utilized data from a genome-wide association study (GWAS) of R.A. susceptibility. They then developed a polygenic risk score (PRS) and tested it to predict radiographic progression in people with rheumatoid arthritis. Earlier studies identified specific genetic factors for R.A. progression, including anti-citrullinated protein antibodies (ACPAs) and variants in the human leukocyte antigen (HLA) region of the chromosome that regulates the immune system. Those are useful but not considered robust. Their new analysis found that patients with a higher PRS had a higher risk of severe progression, particularly in people who were younger at the onset.
microRNAs Unique to Human Beings
Student researchers atJohn Jay College of Criminal Justiceidentifiedhuman microRNA genes that are not found in any other primate species. They believe they may have had a significant role in the evolution of human beings. They found at least three families of microRNA genes on chromosome 21. They leveraged genome alignment tools and compared the most recent versions of human and chimpanzee genomes, working to find genetic elements unique to humans.
On chromosome 21, they found a large region of unique DNA called 21p11, which harbors several orphan microRNA genes. The long arm of human chromosome 21 matches up well with other ape species, but the short arm aligns poorly. The microRNAs in that region, specifically miR3648 and miR6724, probably evolved since the chimpanzee and human lineages split probably in the last seven million years.
Organs Age at Different Rates
Youre only as old as you feel, right? Well, maybe. Butnew researchout of theBeijing Genomics InstituteandChina National GeneBankin Shenzhen, China, found that different organs and systems have different ages from a biological perspective.
Using biomarkers, statistical modeling, and other tools, they analyzed the aging in 4,066 volunteers who supplied blood and stool samples, facial skin images, and to undergo physical fitness examinations. They were between the ages of 20 and 45 years. They measured 403 features: 74 metabolomic features, 34 clinical biomarkers, 10 electroencephalography features, 16 facial skin features, and 210 gut microbiome features. They then classified them into nine categories, including cardiovascular-related, renal-related, liver-related, sex hormone, facial skin, nutrition and metabolism, immune system, physical fitness-related and gut microbiome features. They found that the biological ages of different organs and bodily systems had diverse correlations. They also examined single nucleotide polymorphisms (SNPs) and identified certain genetic changes associated with aging-related pathways.
FDA-Approved Drug Halts RAS-Based Tumor Growth
Researchers with theUniversity of California, San Franciscousedan FDA-approved drug to stop tumor growth in cancers driven by mutations in the RAS gene. RAS mutations are typically difficult to treat and make up about one in four cancer deaths. They found that cancer cells require a reactive form of iron called ferrous iron. They then modified an anticancer drug to work only on these iron-rich cells, allowing other cells to function normally. They focused their research on RAS-mutated pancreatic and gastrointestinal cancers. Cobimetinib and similar drugs are effective at blocking the excessive growth stimulated by RAS mutations and do the same thing in non-cancer tissue, which causes serious side effects that lead many patients to discontinue treatment. They modified cobimetinib to have a small molecule that senses ferrous iron, which essentially shuts cobimetinib off until it meets up with ferrous iron in the cancer cells.
By removing toxicity from the equation, youre talking not just about one new drug, but 10 new combinations that you can now think about exploring in the clinic, said Adam Renslo, a pharmaceutical chemist at UCSF and co-author of the study. That would be the home run for this approach.
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Research Roundup: Genetic Variants Associated with Severe COVID-19 and More - BioSpace
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