Monthly Archives: February 2022

Currently theres no cure for rare types of cystic fibrosis, but researchers are making significant advances – Modern Diplomacy

Posted: February 3, 2022 at 3:38 pm

Current treatments for cystic fibrosis are not suitable for all patients. The lack of treatment options is distressing for people suffering from a rare type of this degenerative and life-threatening disease. But researchers are making major advances.

A decade ago, few cystic fibrosis patients lived beyond their teens. Thanks to a breakthrough in treatment options, for most patients with access to modern medicines, cystic fibrosis (CF) is no longer the catastrophic disease it once was. However, for 15% of people with CF, the cellular defect that causes their disease remains untreatable. For these patients, drugs are available to treat some of the symptoms of CF, but the condition continues to wreak havoc with their organs, resulting in premature death.

An EU-funded research projectHIT-CFaims to change this by improving both the quality of life and the disease prognosis for people with ultra-rare varieties of CF. In Europe, there are an estimated 5,250 people who fall into this category.

The project, launched in January 2018, brings together researchers, doctors, pharmaceutical companies and patient representatives, with the aim of developing drugs and drug combinations that are matched with a high degree of precision to a patient, regardless of the rarity of their form of the disease. Such personalised medicine is possible thanks to a new approach to drug testing involving the creation of mini-organs in the lab using a patients own stem cells. These organoids are genetic replicas of organs found inside the patients body and can be used to test how responsive a persons cells are to specific pharmaceutical compounds.

Were effectively shifting therapeutic trials from patients to the laboratory, explained Kors van der Ent, professor in paediatric pulmonology at the University Medical Centre, Utrecht in the Netherlands, and coordinator of the multi-disciplinary HIT-CF project.

To date, scientists involved in the project have grown organoids from 500 European patients with ultra-rare forms of CF. Ultra-rare can mean that just one or two people worldwide share the same form of the disease.

Describing his teams work with organoids, Professor van der Ent said: Weve asked pharmaceutical companies to hand over drugs from their development pipelines so we can test these compounds against the organoids. These drug candidates target the basic protein defect involved in cystic fibrosis.

What is special about this work is that it means we can create highly personalised treatments for patients with rare mutations. Whats also special is that we can mix and match compounds from different companies to see if patients are responsive to a certain combination of drugs.

From April, the projects clinicians will start testing compounds that have proven to be effective on organoids on real-life patients. We expect these patients to respond well, said Professor van der Ent. We hope that within five years, these patients will have new drugs.

Targeting the cystic fibrosis gene

One in 35 people carries the faulty gene that causes CF usually without knowing. Two people carrying the faulty gene have a 25% chance of having a child born with the disease. Without modern treatment, most people born with CF do not live long beyond their thirties.

Until recently, the only way to treat CF was with antibiotics to fight infection, steroids to reduce inflammation, physiotherapy to clear airways, exercise, nutrition and transplants (of the lungs, liver and sometimes other organs). Although the disease still remains incurable, since 2012, a new class of drugs called modulators has transformed treatment for many.

CFTR modulators target specific defects in the CFTR protein, thereby restoring healthy function of the protein so that chloride (which is present in salt) can flow across the cell surface. To date,four such modulators have reached the market, and these drugs are both transforming the quality of patients lives and lengthening their lifespan substantially.

Thanks to these drugs, in some patients theres a lung-function improvement of 30-40% and life expectancy can increase from the age of 30-40 to 60-80, said Professor van der Ent. In other words, there can be a normal life expectancy.

One significant downside of CFTR modulators is their price: treatment costs up to 200,000 per patient per year. As a result, only patients in countries with a well-funded health service can access medication. Meanwhile, many patients in Eastern Europe, along with other less developed parts of the world, are missing out.

Another drawback and one that HIT-CF aims to address is that CFTR modulators are only being clinically tested in patients with well-described, common mutations of CF. There are up to 2,000 genetic mutations that lead to CF, but just 120 of these are responsible for 80-85% of disease occurrence. It is patients with these common forms of the condition who are able to benefit from the CFTR modulators currently on the market.

So why are patients with rare mutations being left behind? The high cost of clinical trials means it simply does not make commercial sense for drug companies to focus their efforts on this sub-group of CF patients.

Step in organoid technology

Scientists involved in the HIT-CF project are taking tissue samples from the rectum of patients with rare forms of CF, isolating stem cells, and growing these to form mini-intestines.

There are two major advantages of using organoids to screen potential drugs: there are no safety considerations for the patient, and the screening process is highly efficient (any number of compounds from a library of potential drug candidates can be thrown at an organoid, and at speed). As a result, the potential cost savings are vast. For participants of the HIT-CF project, this is great news.

This study is giving people who have been excluded from clinical studies the chance to be recruited for a study and to find medicines that will tackle the causes of their disease, said Dr Elise Lammertyn, head of research at the European federation of national CF patient organisationsCystic Fibrosis Europe, a partner in the HIT-CF project.

There are quite a few (conventional) clinical trials going on in Europe for cystic fibrosis, but most of these are only open to those with the most common mutations of the disease, and the 10-15% of people with ultra-rare mutations are left out in the cold. This new study is about personalised medicine at its most innovative.

Universal access to treatment

Prof. van der Ent, in partnership with other scientists involved in CF research, is set to launch Fair Therapeutics a company that will set out to use organoid technology to bring CF drugs to market for patients with both common and rare mutations, at affordable prices.

In a sense well be competitors to big pharma but actually we will all be working towards the same goal of reaching all CF patients, said Professor van der Ent.

First, however, the project scientists must acquire permission from the European Medicines Agency (EMA) to approve organoid testing so it can be used beyond the current study. It will be very helpful to have a test in the lab that can be used in conjunctionwith less lengthy clinical trials to prove the effectiveness of drugs in small groups of people, said Professor van der Ent. It will highly speed up the pipeline of new drugs for all kinds of diseases, not just CF. It could even be used as a predictive tool for cancer treatment: you do a biopsy of a tumour, add chemotherapy and other drugs to the organoid, and then use the most sensitive treatment on the tumour.

The research in this article was funded by the EU. This article was originally published in Horizon, the EU Research and Innovation Magazine.

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Ali Bagautinov Clinches 2021 BRAVE CF Fighter Of The Year, rare slam gets KOTY award – FightBook MMA

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Living up to his moniker The King Puncher with a career-defining 12 months, in which he claimed three noteworthy victories to inch him closer to a chance of vying for a World Title in the flyweight division,Ali Bagautinov was voted by fans as BRAVE CFs 2021 Fighter of The Year.

Even among the dominant World Champions, serial finishers, and other stars on the BRAVE CF roster, no one can quite match his run in 2021 as he won all of his bouts that included two wins in the prestigious BRAVE CF Flyweight Title Tournament to punch a ticket to the finals against the highly-touted Velimurad Alkhasov at a yet-to-be-announced event in 2022.

Bagautinov kicked off his 2021 by making his highly-anticipated promotional debut at BRAVE CF 46 this past January, dominating Oleg Lichkovakha throughout three rounds to clinch a clear-cut unanimous decision win and secure a slot in the BRAVE CF Flyweight World Title Tournament.

The Russian dynamo then picked up where he left off nearly three months later by eliminating fellow veteran Dustin Ortiz from the tourney in the same fashion at BRAVE CF 50.

At BRAVE CF 55, The King Puncher capped off his amazing run by stopping short-notice opponent Sean Santella in 61 seconds to set a date with Alkhasov for the inaugural BRAVE CF Flyweight World Championship.

Joining Bagautinov is Nursulton Ruziboev, who won the KO Of The Year award for a rare slam KO win reminiscent of Quinton Jackson vs Ricardo Arona, when he knocked out Ibrahim Mane at BRAVE CF 47.

Asu Almabaev, the Flyweight star from Kazakhstan, won two prizes sub of the year for his rear-naked choke finish of Aleksander Doskalchuk, and breakthrough fighter of the year.

Finally, a Super Welterweight war between Ismail Naurdiev and Olli Santalahti, at BRAVE CF 54, was voted Fight of The Year.

BRAVE CF 2021 Award Winners

Roberto Villa is the CEO, Founder, Executive Writer, Senior Editor of FightBook MMA. Has a passion for Combat Sports and also a podcast host for Sitting Ringside. Hes also a former MMA fighter and Kickboxer.

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Ali Bagautinov Clinches 2021 BRAVE CF Fighter Of The Year, rare slam gets KOTY award - FightBook MMA

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CF INDUSTRIES HOLDINGS, INC. : Entry into a Material Definitive Agreement, Material Modification to Rights of Security Holders, Financial Statements…

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Item 1.01 Entry into a Material Definitive Agreement.

On January 28, 2022, CF Industries Holdings, Inc. ("CF Industries") and CFIndustries, Inc. ("CFI") entered into supplements to the indentures governingCFI's 3.450% Senior Notes due 2023 (the "2023 Notes"), 4.500% Senior SecuredNotes due 2026 (the "2026 Notes"), 5.150% Senior Notes due 2034 (the "2034Notes") and 4.950% Senior Notes due 2043 (the "2043 Notes"), and on January 31,2022, CF Industries and CFI entered into a supplement to the indenture governingCFI's 5.375% Senior Notes due 2044 (the "2044 Notes," and the 2023 Notes, the2026 Notes, the 2034 Notes, the 2043 Notes and the 2044 Notes being referred toherein in each case as a "series of Notes" and collectively as the "Notes"),with Wells Fargo Bank, National Association ("Wells Fargo"), as trustee (and,with respect to the 2026 Notes, as collateral agent). The supplement in the caseof each series of Notes provided for amendments of the applicable indenture toremove CF Industries' United Kingdom subsidiaries from the definition ofSignificant Subsidiary (as defined in such indenture) and from being consideredto be part of a group of subsidiaries of CF Industries that would, takentogether, constitute a Significant Subsidiary of CF Industries. In the case ofeach series of Notes, CFI received consent to such amendments from holders of amajority of the outstanding aggregate principal amount of such series of Notes.The amendments in the case of each series of Notes became operative onFebruary 1, 2022, upon payment by CFI of a consent fee to the consenting holdersof such series of Notes.

The foregoing description of the indenture supplements is qualified in itsentirety by reference to the full text of the supplements with respect to the2023 Notes, the 2026 Notes, the 2034 Notes, the 2043 Notes and the 2044 Notes,which are attached hereto as Exhibits 4.1, 4.2, 4.3, 4.4 and 4.5, respectively,and incorporated herein by reference.

Wells Fargo is a lender under CFI's Revolving Credit Agreement (as definedbelow). Wells Fargo has advised CF Industries that Computershare Limited("Computershare") completed the acquisition of the assets of Wells FargoCorporate Trust Services on November 1, 2021, and that the trusteeships underthe indentures governing the Notes would transfer to an affiliate ofComputershare at a time to be determined. An affiliate of Computershare is thetransfer agent and registrar for CF Industries' common stock.

On January 27, 2022, CF Industries and CFI entered into that certain AmendmentNo. 1 to the Fourth Amended and Restated Credit Agreement, dated as of January27, 2022 (the "Credit Agreement Amendment"), with the lenders party thereto, theissuing banks party thereto and Citibank, N.A. ("Citibank") as administrativeagent. The Credit Agreement Amendment amended that certain Fourth Amended andRestated Credit Agreement, dated as of December 5, 2019 (as amended, restated,amended and restated, supplemented, waived or otherwise modified prior to thedate of the Credit Agreement Amendment, the "Existing Credit Agreement", theExisting Credit Agreement, as amended by the Credit Agreement Amendment, the"Revolving Credit Agreement"), among CF Industries, CFI, the lenders partythereto, the issuing banks party thereto and Citibank as administrative agent,to, among other things, exclude each of CF Industries' United Kingdomsubsidiaries and each of their subsidiaries from being a Material Subsidiary (asdefined in the Revolving Credit Agreement) of CF Industries under the RevolvingCredit Agreement. The Credit Agreement Amendment also (i) changed the thresholdabove which a subsidiary would constitute a Material Subsidiary from 5% of theconsolidated total assets of CF Industries and its subsidiaries to 10% ofconsolidated total assets of CF Industries and its subsidiaries and (ii)replaced the threshold above which a subsidiary would constitute a MaterialSubsidiary from 5% of consolidated gross sales of CF Industries and itssubsidiaries to 10% of consolidated EBITDA of CF Industries and itssubsidiaries. Furthermore, the Credit Agreement Amendment changed the referencerate for (i) borrowings under the Revolving Credit Agreement denominated inEuros from LIBOR to EURIBOR and (ii) borrowings under the Revolving CreditAgreement denominated in Sterling from LIBOR to SONIA.

The foregoing description of the Credit Agreement Amendment is qualified in itsentirety by reference to the full text of the Credit Agreement Amendment, whichis attached hereto as Exhibit 4.6 and incorporated herein by reference.

Each of the lenders and issuing banks party to the Revolving Credit Agreement,Citibank and certain of their respective affiliates have performed or may in thefuture perform various commercial banking, lending, investment banking,financial advisory, trustee, hedging or other services for CF Industries, CFIand subsidiaries and affiliates of CF Industries and CFI for which they havereceived or will receive fees and reimbursement of expenses.

Item 3.03 Material Modification to Rights of Security Holders.

The information in Item 1.01 of this report with respect to the 2023 Notes, the2034 Notes, the 2043 Notes and the 2044 Notes is incorporated by reference inthis Item 3.03.

Item 9.01 Financial Statements and Exhibits.

Exhibit No. Description of Exhibit

104 Cover Page Interactive Data File (the cover page XBRL tags are embedded

Edgar Online, source Glimpses

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CF INDUSTRIES HOLDINGS, INC. : Entry into a Material Definitive Agreement, Material Modification to Rights of Security Holders, Financial Statements...

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Modern warfare – Wikipedia

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Contemporary warfare as contrasted with previous methods

Modern warfare is warfare that is in notable contrast with previous military concepts, methods, and technology, emphasizing how combatants must modernize to preserve their battle worthiness.[1] As such, it is an evolving subject, seen differently in different times and places. In its narrowest sense, it is merely a synonym for contemporary warfare.

In its widest sense, it includes all warfare since the "gunpowder revolution" that marks the start of early modern warfare, but other landmark military developments have been used instead, including the emphasis of artillery marked by the Crimean War, the military reliance on railways beginning with the American Civil War, the launch of the first dreadnought in 1905, or the use of the machine gun, aircraft, tank, or radio in World War I.[2] In other senses, it is tied to the introduction of total war, industrial warfare, mechanized warfare, nuclear warfare,[3] counter-insurgency,[4] or (more recently) the rise of asymmetric warfare also known as fourth-generation warfare.[5]

Some argue that the changing forms of third generation warfare represents nothing more than an evolution of earlier technology.[6]

Aerial warfare is the use of military aircraft and other flying machines in warfare. Aerial warfare includes bombers attacking enemy concentrations or strategic targets; fighter aircraft battling for control of airspace; attack aircraft engaging in close air support against ground targets; naval aviation flying against sea and nearby land targets; gliders, helicopters and other aircraft to carry airborne forces such as paratroopers; aerial refueling tankers to extend operation time or range; and military transport aircraft to move cargo and personnel.

A military situation in which two belligerents of unequal strength interact and take advantage of their respective strengths and weaknesses. This interaction often involves strategies and tactics outside conventional warfare.

Biological warfare, also known as germ warfare, is the use of any organism (bacteria, virus or other disease-causing organism) or toxin found in nature, as a weapon of war. It is meant to incapacitate or kill enemy combatants. It may also be defined as the employment of biological agents to produce casualties in man or animals and damage to plants or material; or defense against such employment. Biological warfare involves the intentional release of living pathogens either in their naturally occurring form, for example the diseased corpses of animals, or in the form of specific human-modified organisms.

Chemical warfare is warfare (associated military operations) using the toxic properties of chemical substances to incapacitate or kill enemy combatants. Chemical warfare nerve agents are potent anticholinesterase compounds deliberately formulated to induce debilitating effects or death during wartime hostilities. A key need for both community emergency preparedness, and restoration of military installations where agents have been processed and/or stored, is access to concise and timely information on agent characteristics and treatment, as well as health-based exposure guidelines derived in a clear manner by contemporary methods of data analysis.

Electronic warfare refers to mainly non-violent practices used chiefly to support other areas of warfare. The term was originally coined to encompass the interception and decoding of enemy radio communications, and the communications technologies and cryptography methods used to counter such interception, as well as jamming, radio stealth, and other related areas. Over the later years of the 20th century and early years of the 21st century, this has expanded to cover a wide range of areas: the use of, detection of and avoidance of detection by radar and sonar systems, computer hacking, etc.

Fourth generation warfare (4GW) is a concept defined by William S. Lind and expanded by Thomas X. Hammes, used to describe the decentralized nature of modern warfare. The simplest definition includes any war in which one of the major participants is not a state but rather a violent ideological network. Fourth Generation wars are characterized by a blurring of the lines between war and politics, combatants and civilians, conflicts and peace, battlefields and safety.

While this term is similar to terrorism and asymmetric warfare, it is much narrower. Classical insurgencies and the Indian Wars are examples of pre-modern wars, not 4GW. Fourth generation warfare usually has the insurgency group or non-state side trying to implement their own government or reestablish an old government over the one currently running the territory. The blurring of lines between state and non-state is further complicated in a democracy by the power of the media.

Ground warfare involves three types of combat units: infantry, armor, and artillery.

Infantry in modern times would consist of mechanized infantry and airborne forces. Usually having a type of rifle or sub-machine gun, an infantryman is the basic unit of an army.

Armored warfare in modern times involves a variety of armored fighting vehicles for the purpose of battle and support. Tanks or other armored vehicles (such as armored personnel carriers or tank destroyers) are slower, yet stronger hunks of metal. They are invulnerable to enemy machine gun fire but prone to rocket infantry, mines, and aircraft so are usually accompanied by infantry. In urban areas, because of smaller space, an armored vehicle is exposed to hidden enemy infantry but as the so-called "Thunder Run" at Baghdad in 2003 showed, armored vehicles can play a critical role in urban combat. In rural areas, an armored vehicle does not have to worry about hidden units though muddy and damp terrain that have always been a factor of weakness for tanks and vehicles.

Artillery in contemporary times is distinguished by its large caliber, firing an explosive shell or rocket, and being of such a size and weight as to require a specialized mount for firing and transport. Weapons covered by this term include "tube" artillery such as the howitzer, cannon, mortar, field gun, and rocket artillery. The term "artillery" has traditionally not been used for projectiles with internal guidance systems, even though some artillery units employ surface-to-surface missiles. Recent advances in terminal guidance systems for small munitions has allowed large caliber shells to be fitted with precision guidance fuses, blurring this distinction.

Guerrilla warfare is defined as fighting by groups of irregular troops (guerrillas) within areas occupied by the enemy. When guerrillas obey the laws and customs of war, they are entitled, if captured, to be treated as ordinary prisoners of war; however, they are often treated by their captors as unlawful combatants and executed. The tactics of guerrilla warfare stress deception and ambush, as opposed to mass confrontation, and succeed best in an irregular, rugged, terrain and with a sympathetic populace, whom guerrillas often seek to win over or dominate by propaganda, reform, and terrorism. Guerrilla warfare has played a significant role in modern history, especially when waged by Communist liberation movements in Southeast Asia (most notably in the Vietnam War) and elsewhere.

Guerrilla fighters gravitate toward weapons which are easily accessible, low in technology, and low in cost. A typical arsenal of the modern guerrilla would include the AK-47, RPGs, and Improvised explosive devices. The guerrilla doctrines' main disadvantage is the inability to access more advanced equipment due to economic, influence, and accessibility issues. They must rely on small unit tactics involving hit and run. This situation leads to low intensity warfare, asymmetrical warfare, and war amongst the people. The rules of Guerrilla warfare are to fight a little and then to retreat.

Propaganda

Propaganda is an ancient form of disinformation concerted with sending a set of messages aimed at influencing the opinions or behavior of large numbers of people. Instead of impartially providing information, propaganda in its most basic sense presents information in order to influence its audience. The most effective propaganda is often completely truthful, but some propaganda presents facts selectively to encourage a particular synthesis, or gives loaded messages in order to produce an emotional rather than rational response to the information presented. The desired result is a change of the cognitive narrative of the subject in the target audience.

Psychological

Psychological warfare had its beginnings during the campaigns of Genghis Khan through the allowance of certain civilians of the nations, cities, and villages to flee said place, spreading terror and fear to neighboring principalities. Psychological actions have the primary purpose of influencing the opinions, emotions, attitudes, and behavior of hostile foreign groups in such a way as to support the achievement of national objectives.

Information

Made possible by the widespread use of the electronic media during World War II, Information warfare is a kind of warfare where information and attacks on information and its system are used as a tool of warfare. Some examples of this type of warfare are electronic "sniffers" which disrupt international fund-transfer networks as well as the signals of television and radio stations. Jamming such signals can allow participants in the war to use the stations for a misinformation campaign.

Naval warfare takes place on the high seas (blue water navy). Usually, only large, powerful nations have competent blue water or deep water navies. Modern navies primarily use aircraft carriers, submarines, frigates, cruisers, and destroyers for combat. This provides a versatile array of attacks, capable of hitting ground targets, air targets, or other seafaring vessels. Most modern navies also have a large air support contingent, deployed from aircraft carriers[dubious discuss]. In World War II, small craft (motor torpedo boats variously called PT boats, MTBs, MGBs, Schnellboote, or MAS-boats) fought near shore. This developed in the Vietnam War into riverine warfare (brown water navy), in intertidal and river areas. Irregular warfare makes this sort of combat more likely in the future.

Network-centric warfare is essentially a new military doctrine made possible by the Information Age. Weapons platforms, sensors, and command and control centers are being connected through high-speed communication networks. The doctrine is related to the Revolution in Military Affairs debate.

The overall network which enables this strategy in the United States military is called the Global Information Grid.

Nuclear war is a type of warfare which relies on nuclear weapons. There are two types of warfare in this category. In a limited nuclear war, a small number of weapons are used in a tactical exchange aimed primarily at enemy combatants. In a full-scale nuclear war, large numbers of weapons are used in an attack aimed at entire countries. This type of warfare would target both combatants and non-combatants.

Space warfare is the hypothetical warfare that occurs outside the Earth's atmosphere. No wars have been fought here yet. The weapons would include orbital weaponry and space weapons. High value outer space targets would include satellites and weapon platforms. Notably no real weapons exist in space yet, though ground-to-space missiles have been successfully tested against target satellites. As of now, this is purely science fiction.

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US Military Released Bacteria to Test Biological Warfare

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On September 20, 1950, a US Navy ship just off the coast of San Francisco used a giant hose to spray a cloud of microbes into the air and into the city's famous fog. The military was testing how a biological weapon attack would affect the 800,000 residents of the city.

The people of San Francisco had no idea.

The Navy continued the tests for seven days, potentially causing at least one death. It was one of the first large-scale biological weapon trials that would be conducted under a "germ warfare testing program" that went on for 20 years, from 1949 to 1969. The goal "was to deter [the use of biological weapons] against the United States and its allies and to retaliate if deterrence failed," the government explained later. "Fundamental to the development of a deterrent strategy was the need for a thorough study and analysis of our vulnerability to overt and covert attack."

Of the 239 known tests in that program, San Francisco was notable for two reasons, according to Dr. Leonard Cole, who documented the episode in his book "Clouds of Secrecy: The Army's Germ Warfare Tests Over Populated Areas."

Cole, now the director of the Terror Medicine and Security Program at Rutgers New Jersey Medical School, tells BusinessInsider that this incident was "notable: first, because it was really early in the program ... but also because of the extraordinary coincidence that took place at Stanford Hospital, beginning days after the Army's tests had taken place."

Hospital staff were so shocked at the appearance of a patient infected with a bacteria, Serratia marcescens, that had never been found in the hospital and was rare in the area, that they published an article about it in a medical journal. The patient, Edward Nevin, died after the infection spread to his heart.

S. marcescens was one of the two types of bacteria the Navy ship had sprayed over the Bay Area.

It wasn't until the 1970s that Americans, as Cole wrote in the book, "learned that for decades they had been serving as experimental animals for agencies of their government."

San Francisco wasn't the first or the last experiment on citizens who hadn't given informed consent.

Other experiments involved testing mind-altering drugs on unsuspecting citizens. In one shocking, well-known incident, government researchers studied the effects of syphilis on black Americans without informing the men that they had the disease they were told they had "bad blood." Researchers withheld treatment after it became available so they could continue studying the illness, despite the devastating and life-threatening implications of doing so for the men and their families.

But it was the germ warfare tests that Cole focused on.

"All these other tests, while terrible, they affected people counted in the hundreds at most," he says. "But when you talk about exposing millions of people to potential harm, by spreading around certain chemicals or biological agents, the quantitative effect of that is just unbelievable."

"Every one of the [biological and chemical] agents the Army used had been challenged" by medical reports, he says, despite the Army's contention in public hearings that they'd selected "harmless simulants" of biological weapons.

"They're all considered pathogens now," Cole says.

Here are some of the other difficult-to-believe germ warfare experiments that occurred during this dark chapter in US history. These tests were documented in Cole's book and verified by Business Insider using congressional reports and archived news articles.

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This week in Texas History: Spanish flu, our ancestors’ pandemic – Hays Free Press

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By Bartee Haile

Just when Texans started to think the Spanish Flu had finally run its course, on Feb. 4, 1920 the State Health Department reported 2,514 new cases in the past 24 hours.

The deadly strain of influenza that caused the worldwide epidemic at the end of the First World War was called the Spanish Flu because the outbreak in that country that killed eight million in May 1918 received the most attention. As a noncombatant, Spain had no wartime censorship. Interestingly enough, the Spaniards themselves named the scourge the French Flu.

The Great Pandemic was genuinely global in scope. The only place on the planet to escape the calamity was a small island deep in the Amazon jungle. No one really knows how many lives were lost, but estimates of the worldwide death toll ranged from 40 to 100 million making the twentieth-century pandemic the deadliest in human history.

The Spanish Flu struck healthy individuals, usually the young rather than the old, without warning. In a matter of hours, victims were too weak to walk and had to take to bed. Of those that died, the end often came the very next day. The stricken rarely lingered longer than three days after infection.

The symptoms were ghastly. As the lungs failed, victims turned black or blue from lack of oxygen and bled from the nose, ears and eyes. And, as one historian wrote, Patients would writhe from agonizing pain in their joints.

Although victims were advised to send for a doctor as soon as they came down with Spanish Flu, there was little a physician could do when he arrived. Penicillin would not be discovered until 1928, and it was not until 1943 that an influenza vaccine became available.

The first documented case in the United States occurred on March 11, 1918 at Fort Riley, Kansas, when army cook showed up at sick call with a temperature of 103. Forty-eight hours later, 522 soldiers were flat on their backs.

Later that summer, a more virulent form of the Spanish Flu, undoubtedly carried by returning doughboys, hit Boston. The sickness spread like wildfire through the crowded cities on the East Coast, killing 800 a day in New York City, before heading west.

In the absence of a scientific explanation for the cause and with no cure, hysteria and ignorance filled the void. One popular theory was that the Spanish Flu was part of a germ-warfare attack by the Germans, while others blamed cat hair and coal dust. The long list of useless home remedies included everything from onions and garlic to goose grease.

The Surgeon Generals antidote for such nonsense was four basic precautions: 1) Keep out of crowds. 2) Cover up each cough and sneeze. 3) Do not spit on the floor or sidewalk. 4) Shun the common drinking cup and the roller towel in public places.

Texans could only wait and hope for the best. Maybe by some sort of miracle the Spanish Flu would skip the Lone Star State. But it didnt.

The suspense ended on Sept. 23, 1918 with the first confirmed sightings of the sickness in Williamson, Kaufman and Bosque counties. Eleven days later, 35 counties were under siege, and a week after that the number had grown to 77.

Towns throughout Texas moved quickly to protect the public over the objections of local merchants and skeptics, who pooh-poohed the danger. On Oct. 9 alone the following communities closed schools, theaters and other gathering places: Lewisville, Plano, Marshall, McKinney, Bonham, Wills Point, Clarksville, Cleburne, Temple, Wichita Falls, Waxahachie, Houston and Corsicana.

By late October, the Spanish Flu had reached the Panhandle with the death of the president of Wayland Baptist College in Plainview on the 28th, and El Paso, where the number of cases neared 5,000 by the 23rd. On the 29th, the State Health Department reported 106,978 cases and 2,181 deaths and that was just in the cities.

Galvestons response to the worst public health crisis since the yellow fever epidemics of the 1800s was typical of most towns. City officials and the daily newspapers saw panic as the greatest enemy and in their efforts to keep everybody calm often painted too rosy a picture of a truly grave situation.

Any decline in the daily death toll was hailed by politicians and The Daily News as a sign the worst was over. Carried away by encouraging numbers in early November, the health commissioner lifted the ban on public places and reopened the schools.

But this unfounded optimism ignored the fact that the Spanish Flu came in waves and would hang on in Texas well into 1920. When the disease returned with a vengeance killing 65 Galvestonians between Nov. 15 and Dec. 15, the commissioner was forced to shut the city down again.

The final figures for the United States, nothing more than educated guesses, had one out of every four Americans stricken by the Spanish Flu and at least half a million fatalities in a population of 105 million. As for the four and half million Texans, 30 to 40 percent contracted the disease and five to ten percent of the afflicted perished. Thats 70,000 dead in the best case and upwards of 175,000 in the worst.

Bartee welcomes your comments and questions at barteehaile@gmail.com or P.O. Box 130011, Spring, TX 77393 and invites you to visit his web site barteehaile.com.

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Yamashita: Boundaries should be respected | Opinion | guampdn.com – Guam Pacific Daily News

Posted: at 3:37 pm

Many of us continue to steady our steps. The germ warfare has us on a carousel going up and down and all around.

We have learned that vaccinations and good health practices make a difference. We know the high vaccination rate on Guam is a safety net for our health care system.

Emotionally, stressors come from all points. Closures, work, prices, empty shelves challenge us to be even more patient, focused and creative. Our hope for better times keeps us steady.

A lack of decorum from elected officials unsettles that hope. If the Guam Legislature has organizational issues with attendance practices, it can address that internally. If the Guam Legislature has issues with the performance of committee members and officers, it can address that in joint caucus.

As a former senator, I learned when I was present at a majority, if not all, public hearings and committee meetings, there were a variety of acceptable strategies to fully engage in legislative business. I learned that Families First should concentrate on its office and while it should certainly foster relationships with others, it should trust individual senators to be accountable for their efforts.

The people are astute enough to know who is getting the peoples work done. The people will decide, as they always do.

Do not misunderstand me. Heated discussion about policy, programs and practices is vital. Best steps result as discourse, data, research, stakeholder input and visionary sights take the stage. We elect our leaders to make the best decisions possible for all of us to live, work, pray, learn, dream and play safely, fairly and happily to our potential.

As officials live in glass houses, boundaries should be respected for private matters, especially when we already know tragedy and high-risk health issues are being addressed, especially when we already know health care being sought isnt available on Guam, especially when we know that deliverables continue to be addressed.

We have little control over many Guam decisions. We do have control over our relationships with each other. Even as we disagree, respect and regard especially as we are just healing from the health crisis are expected from our officials. Further concern hampers recovery.

Vice Speaker Tina Mua Barnes tele-working has made progress on Guam issues transshipment, COFA renegotiations, affordable homes. She continues to do her work on the Guma Mami Board. Most recently, her measure to identify haul-road highways that aims to help control Guam prices passed.

I dont know if Tina is seeking re-election. What I do know is that she continues to deliver for our families as she cares for hers. What I do know is that she is deserving of respect, regard and restraint as she steadies her footing.

We may not be able to control treatment from others, but certainly we can temper treatment among ourselves. Respect, regard, restraint standards of behavior we expect from those who call Guam home.

Aline Yamashita, Ph.D., is a teacher, single mother and former senator.

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How to see the photo the Hubble Space Telescope took on your birthday – The Scotsman

Posted: at 3:37 pm

Since 1990, the Hubble Space Telescope has floated through space, taking pictures of the universe 24 hours a day, seven days a week - meaning that in its time, it has witnessed some incredible cosmic events.

Using a tool on the Nasa website, you can see what deep-space images the telescope captured on your birthday.

This is everything you need to know.

What is the Hubble Telescope?

The Hubble Space Telescope, also known as just the Hubble, is a huge telescope in space, which Nasa launched in 1990.

According to the space agency, the Hubble is as long as a large school bus and weighs as much as two adult elephants. The Hubble spends its time travelling around earth at around five miles per second, which is the equivalent of driving a car from the east coast of the US to the west coast in just 10 minutes.

The telescope faces towards space, and it takes pictures of planets, stars and galaxies. It has witnessed the birth and death of stars, black holes, galaxies that are trillions of miles away and has even seen comet pieces crash into the gases above Jupiter.

Nasa says that the Hubble has fundamentally changed our understanding of the cosmos, and its story - filled with challenges overcome by innovation, determination, and the human spirit - inspires us.

The telescope got its name from Edwin P Hubble, who was an astronomer who made important discoveries about the universe in the early 1990s.

Astronauts have visited the Hubble five times to fix it, adding new parts and cameras to the telescope. In 2020, it turned 30 years old.

How do I use the feature?

Nasa says: The Hubble explores the universe 24 hours a day, 7 days a week. That means it has observed some fascinating cosmic wonder every day of the year, including on your birthday.

To see with the Hubble saw on your birthday, you just need to head to the Nasa website.

From there, select the month and date that you were born and hit submit to see what it saw on your birthday.

Youll be shown a picture and will be given some information about what the Hubble saw. If you click on the more information option, youll be taken to a new webpage on the Hubble site which tells you all about the image.

You can easily share your image to social media, like Twitter, Facebook and Pinterest by clicking on the icons in the upper left corner. Users are encouraged to share their birthday image on social media with the hashtag #Hubble30.

The Nasa website says that for Firefox users, you might need to turn off content blocking for this site in your browser's privacy settings if youre wanting to share your Hubble birthday image on social media.

A text version of the tool is also available for screen readers.

What did the telescope see on notable dates?

These are some examples of what the Hubble Telescope saw on some notable dates throughout the years.

On 25 December 2009, the telescope saw the dwarf galaxy NGC 4215, with the image capturing intricate patterns of glowing hydrogen shaped during the star birthing process, cavities blown clear of gas by stellar winds, and bright stellar clusters.

On 1 January 2012, it saw the galaxy Leo IV, which is one of more than a dozen ultra-faint dwarf galaxies near the Milky Way.

On 31 October 2005, the Hubble saw the nebula NGC 281, with the image showing dark knots of gas and dust called Bok Globules.

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Biden Admin Creates Creepy Database Of Unvaxxed Who …

Posted: at 3:36 pm

A federal agency debuted a new system on Tuesday designed to record and store the information of federal employees who requested religious exemptions from the Biden administrations federal jab mandate.

According to a report by the Daily Signal, the Pretrial Services Agency for the District of Columbia, an independent federal agency designed to aid Washington D.C. courts, created the Employee Religious Exception Request Information System to track unvaccinated employees who ask for religious exemptions from President Joe Bidens federal COVID-19 shot mandate.

The Federal Register describes the new system as the best way to keep track of personal religious information that is collected in the context of a public health emergency or similar health and safety incident, such as a pandemic, epidemic, natural disaster or national or regional emergency and/or any other lawful collection of employee information or data that is necessary to ensure a safe and healthy environment for individuals. Those with concerns about the system only have until Feb. 10 to offer any public comments.

The agency claims that the database will legally allow for the collection, storing, dissemination, and disposal of employee religious exemption request information for an indefinite period of time.

The primary purpose of the secured electronic file repository is to collect, maintain, use, andto the extent appropriate and necessarydisseminate employee religious exception request information collected by the Agency inthe context of the federally mandated COVID-19 vaccination requirement, the register states.

The Daily Signal report notes that the group did not explain specifically why it needed to create a longstanding list and neither does the announcement explain why the Biden administration chose to test this policy in an agency with amajority-black staff, who are bothmore religiousandless vaccinatedthan other groups.

The legal fellows who authored the Daily Signal piece also expressed concern that the Biden administration is using [the database] to stealth test a policy it intends to roll out across the whole government.

Jordan Boyd is a staff writer at The Federalist and co-producer of The Federalist Radio Hour. Her work has also been featured in The Daily Wire and Fox News. Jordan graduated from Baylor University where she majored in political science and minored in journalism. Follow her on Twitter @jordangdavidson.

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Indoctrination Prompts Wave Of Candidates For Texas Board Of Education – The Federalist

Posted: at 3:36 pm

Rampant political indoctrination is a problem affecting many public and private schools in the United States, and Texas is no exception.

When leftist administrations and Democrat-linked teachers unions lobbied to keep students home and glued to iPads during Covid-19 panic, parents in Texas began to pay attention to the racism and radical LGBTQ ideologies schools and libraries have been pushing on children as young as toddlers. The problem crept through the tiniest of rural schools all the way into the top-achieving school district in Texas in the Dallas suburbs until outraged parents took action.

Its not an isolated story. Concerned parents who want more of a say in what their children are learning heavily influenced the results of the Virginia gubernatorial race last year, successfully unseated radical school board members in the Midwest, and are profoundly affecting races in Texas as well. The extremist ideologies in Texas schools have inspired a wave of conservative parents to run in the state board of educations upcoming primaries, as well as in similar races nationwide.

State board of education races can look like down-ballot elections of small significance. In reality, the candidates elected to sit on the 15-member board make decisions that profoundly affect education inside and outside the Lone Star State.

In Texas, the state education board not only determines the curriculum criteria that affect the states 1,029 public school districts, but also approves and vetoes which charter schools will be allowed to operate in Texas.

The Texas State Board of Education races are some of the most important on the ticket because of the almost 6 million Texas public school students whose lives can be irreparably damaged by the type of standards and curriculum the TSBOE adopts, Donna Garner, an education policy commentator at Education Views, noted in an analysis of the race.

This boards decisions are far from cursory. In addition to heavily influencing national education publishers who use the content and methods adopted in large states such as Texas as a model to disseminate similar materials elsewhere, the SBOE also can fend off leftist attempts to slip politically charged content into the states instruction mandates.

Nearly 15 years ago, the Texas SBOE found itself the target of national media coverage after the Texas Education Agencys director of science Christine Castillo Comer said she would not stay neutral about teaching Darwinism even though the board instructed TEA teachers to promote critical thinking in classrooms by examining multiple viewpoints about the origins of life. Contrary to the corporate media narrative, the SBOEs instruction standards did not require creationism or conversations about intelligent design in classrooms but merely asked teachers to refrain from pushing politics and unsupported theories.

As the culture war heightens, Texass SBOE has faced pressure from activists to adopt curricula that not only endorses judging students based on the color of their skin but requires schools to teach leftist politics. These leftists want mandatory workbooks and lessons that paint anti-racism as a solution instead of a problem, amplify extremist climate change agendas, and neglect human biology to promote trans ideology.

Despite Democrats efforts to purple it, Texas is still a red state with no shortage of candidates with an R next to their names on the ballot. The number of SBOE members in recent years who are willing to stand up to the lefts increasing bullying, however, has dwindled severely, prompting culture war conservatives to enter the race. In 10 of the 15 state board of education districts, at least two Republicans are fighting for a spot on the board in advance of it reevaluating key curriculum standards in 2023.

Leftist political indoctrination is a problem plaguing public school districts across the country, but in Texas, its one only the SBOE can address. Its also what inspired some GOP candidates to run this year and participate in the big battleground for a cultural tug-of-war.

One of these candidates, Aaron Kinsey, the CEO of aerial oil pipeline patrol company American Patrols and a father of three children, chose to enter the political arena for the first time after he saw the increasingly negative effects of remote schooling and political indoctrination were having on Texas students. The Republican said he believes schools should be teachingour children to love themselves, their families, their neighbors, their state, and their country, not to choose political sides.

I think youre gonna see a lot more parents getting involved, and I am one of those parents who is stepping up and saying, No, this isnt right. This isnt what we stand for,' Kinsey told The Federalist.

Kinsey is challenging Republican incumbent Jay Johnson to represent District 15, which spans a large chunk of West Texas and the Texas Panhandle. Johnson, who has served on the SBOE since 2020 after he went unchallenged in the primary election, is listed as a Republican.

But during his past term, Johnson vetoed the application of Heritage Classical, a charter school inspired by Hillsdale Colleges classical model and supported by a network of pro-America public charter schools that have been highly successful across the United States for decades. Johnson also voted to approve a charter for Essence Prepatory, which touted quotes from extremist racial grifter Ibram X. Kendi on its website. Johnson did not respond to The Federalists request for comment.

Kinsey said parents strong concerns warrant action that his primary rival might not take.

This system, as it is right now, has a lot of establishment people that are involved with it, who have been around it the whole time or for several decades. And I think its time for a change, Kinsey said. Its time for somebody else who doesnt necessarily have those past experiences and biases with the system to come in and start taking a look with a fresh perspective.

Thats like half the problem here on a lot of these cultural things, like if youre sleeping on it, youre losing, he added.

Michael Barton, a dad of two and police detective, is running for a seat in the board of educations District 7, which also encompasses part of the Houston area. Despite running in a primary crowded with three other Republicans, Barton says his plan for action and willingness to prioritize parents sets him apart from other candidates.

Parents should be front and center. No parent should have to go asking for curriculum or teaching materials from their local school district. I see no reason why this cant all be put online. The needs of the kids should be No. 1, everything else revolves around that, he told The Federalist in an email.

As the SBOE stands now, Republicans technically hold the majority with nine members. Of those, some such as Pat Hardy can be trusted to make pro-school choice and anti-indoctrination decisions.

Other incumbent board members, however, such as Pam Little in District 12, Sue Melton-Malone in District 14, and Jay Johnson in District 15, have swing-vote track records that can only be characterized as bench-warming. These board members might side with conservatives on some issues but they also lack the courage to take the new culture war by the horns.

Some Republican board members such as Matt Robinson in District 7 have decided not to run again, opening doors for new, passionate candidates to potentially take his place. Other strong, conservative SBOE candidates such as Audrey Young, Keven Ellis, and Tom Maynard have pro-school choice and anti-indoctrination track records and the boon of running unopposed.

Culture war conservatives are hoping to make gains in the March primary with new candidates while incumbents with primary challengers are fighting to keep their spot and finish the work they already started in previous terms. Will Hickman, a father of three, is running for re-election in District 6, which spans parts of Houston. He is being challenged by former educator Mike Wolfe.

Since he was elected in 2020, Hickman has voted against far-left climate rhetoric in Texas science curriculum and advocated against a series of radical gender ideology textbooks.

As a conservative, as a Christian, as a parent, I bring the parent perspective to the board, Hickman told The Federalist. Ive enjoyed the past year and Im willing to put my name forward and resume experience and work on the board and see if the voters of the district want to put me back.

Hickman believes students should be prepared for their futures, whether thats college, a career, or the military, and that teaching to a political agenda does not satisfy that.

Lets teach the science, and then leave the policy and politics for social studies. [The board] is just starting on social studies, so Im sure well have the [critical race theory] debate there. For me, CRT is racism. Although some would say its for a good purpose, I disagree. I think any racism should not be taught in Texas schools. One-hundred percent against CRT, he said of his position.

Due to redistricting, a new wave of strong Texas SBOE candidates are up for election or re-election, some shortly after they assumed office for the first time in 2020. The timing couldnt be more perfect as Texas parents, angered by the leftist lies being shoved down little throats, beg for opportunities to challenge radicalism in public schools.

Texas is a large statem and the decisions its SBOE makes will have a large impact on the entire nations education markets. Texas parents are stepping up to keep activist ideologues from messing with Texas students, like parents in other states. The fight to give parents a voice in their childrens education in Texas and across the nation is only beginning.

Jordan Boyd is a staff writer at The Federalist and co-producer of The Federalist Radio Hour. Her work has also been featured in The Daily Wire and Fox News. Jordan graduated from Baylor University where she majored in political science and minored in journalism. Follow her on Twitter @jordangdavidson.

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Indoctrination Prompts Wave Of Candidates For Texas Board Of Education - The Federalist

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