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Monthly Archives: February 2022
Meet Bolk, a Robotic Bowl Food Canteen Company That Just Raised 4M – The Spoon
Posted: February 5, 2022 at 5:15 am
Bolk, a maker of bowl-making robotic canteen, announced today that is has raised 4 million in new funding.
Founded in 2020, the French startup is using the capital to build prototypes which it has already started to deploy around Paris and surrounding areas.
The Bolk canteen bot, which is reminiscent of Chowbotics Sally robot, takes up 2 square meters of floor space and can produce up to 60 meals an hour. The Bolk is completely autonomous and can make a variety of foods, using a mix of sweet, savory, cold or hot ingredients that can make up to 300 total combinations.
The company supplies food ingredients to each robot. Ingredients are pre-cooked in local kitchens in Paris, and Bolk re-stocks each robot twice a week, on Monday and Wednesday.
The company plans to expand in 2022, looking to deploy up to 40 Bolk-bots around France. The initial rollout will be into corporate offices, but the company also has plans to explore other potential venues such as public spaces or retail environments.
The company was founded by Nicolas Jeanne, who like many in this space point to a mission of democratizing fresh food through the use of robotics.
The catering sector is constantly evolving and we are building a new self-service food experience, offering companies and their staff a daily menu of delicious and eco-responsible meals at the best possible prices; meals that are made to order and produced in 45 seconds flat, therefore ultra-fresh, said Jeanne.
You can get a sneak peek at the Bolk in the video below.
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Flashback: Neil Young participated in ‘Freedom of Speech Tour’ before advocating censorship of Joe Rogan – Fox News
Posted: at 5:15 am
Media top headlines February 4
In media news today, an AP reporter spars with the State Departments Ned Price over allegations on Russia, a report claims that Jeff Zucker and Allison Gollust gave Andrew Cuomo COVID talking points to combat Trump, and an MSNBC broadcast gets interrupted by a Lets Go Brandon flag.
Musician Neil Young appears to have had a change of heart when it comes to the right of Americans to say how they feel about a particular political issue, even if others don't agree with them.
The liberal singer threw himself into the headlines last week following a decision to remove his content from Spotify in protest over Joe Rogan's podcast, complaining the latter was spreading misinformation about the coronavirus pandemic to his millions of listeners, and he no longer wanted to share a platform with him.
However, Young's history of speaking out on political issues runs in contrast to his current position on Rogan, considering he participated in a 2006 "Freedom of Speech tour" that traveled the country protesting the then-involvement of U.S. soldiers in Iraq and Afghanistan, often to disagreeable crowds.
Musician Neil Young speaks during a session at the International CES Wednesday, Jan. 7, 2015, in Las Vegas. (AP Photo/John Locher)
JOE ROGAN HITS THE RIGHT NOTE AFTER NEIL YOUNG ATTACK, SPOTIFY PLAYS DEFENSE
"I was a nervous wreck by the end of that tour. I never want to do another tour like that in my life. I mean, that was so different from every other tour Ive done," Young told Rolling Stone in a 2008 interview. "Just getting up in front of a lot of people makes you nervous. But when you know that some of them are really going to be angry at you, and youre in a crowd, and its a volatile situation, people have been drinking, whatever you know, it makes you nervous."
"It was just that critical time in history where things were turning. Things were changing," he added. "Those who feel the way we do had some hope and those who dont feel the way we do were angry that the change happened. And those people have got a voice, and they have a reason for feeling the way they do. They strongly believe in the convictions. They believe in the military."
"They believe that were doing the right thing for the world, and they have every reason to be respected for their beliefs," he said.
Comedian Joe Rogan (Photo by: Vivian Zink/Syfy/NBCU Photo Bank/NBCUniversal via Getty Images)
JOE ROGAN CRITICS NEIL YOUNG AND JONI MITCHELL HAVE THEIR HISTORY OF OFFENSES
Young's then-position on respecting the beliefs of others heavily contrasted his approach to Rogan as he demanded the streaming giant choose between the two.
"They can have [Joe] Rogan or Young," he reportedly posted in a letter to his management team. "Not both."
He also wrote that Spotify has a "responsibility to mitigate the spread of misinformation on its platform, though the company presently has no misinformation policy."
A "Freedom of Speech Tour" poster from 2006 (Freedom of Speech Tour)
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Other artists followed Young's lead by pulling their music from Spotify; however the company opted to keep Rogan's content and instead implemented a "content advisory" label to combat the spread of misinformation.
Rogan also issued an apology and promised to expand the viewpoints he brought onto his show.
Fox Business' Edmund DeMarche contributed to this report.
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Flashback: Neil Young participated in 'Freedom of Speech Tour' before advocating censorship of Joe Rogan - Fox News
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Freedom of speech was too hard won to be cavalier now about censorship – The Guardian
Posted: at 5:15 am
If the great campaigners for free speech of the past, such as Baruch Spinoza or Mary Wollstonecraft or Frederick Douglass, were alive today, they would surely declare the 21st century an unprecedented golden age. So suggests Jacob Mchangama in his new history of free speech.
Its a claim that might raise a few eyebrows. This, after all, is an age in which, from China to Saudi Arabia, dictatorial rulers imprison and kill political opponents with impunity. An age in which governments in formally democratic nations such as India use the judicial system to try to silence critics. An age in which more than 1,400 journalists have been murdered in 30 years. An age in which governments across the globe desperately seek ways of curbing speech on social media they consider dangerous. And in which, in the west, there is a constant debate about cancel culture and the erosion of academic freedom.
Mchangama, a leading campaigner for free speech, is not trying to dismiss the reality of contemporary censorship. He is suggesting, rather, that in historical terms, we have never been more free to speak our minds. But this leads to a paradox. The very fact that, certainly in the west, we live in far more open societies has led many to be sanguine and dismissive of the threat that restrictions on speech can impose upon us. The very success of historical struggles can obscure the lessons of those struggles.
Historically, the demand for free speech was at the heart of the fight for social justice. From the challenge posed by freethinkers in 10th-century Islam to the abolitionist struggle in 19th-century America, from the suffragette movement to campaigns for liberation from colonial rule, there has long been a recognition that democracy, social justice and free speech go hand in hand and that censorship was a weapon wielded by the powerful to stymie social change.
Today, though, the issues seem more confusing. Much censorship, particularly in liberal democracies, is imposed in the name of protecting not the powerful but the powerless or the vulnerable: laws against hate speech, for instance, or restricting the scope of racists or bigots. And where once the left was clearly opposed to censorship, many now support restrictions in the name of the progressive good. As the left has vacated the ground of free speech, the right and the far right have become encamped upon it. This has further distorted the debate, the cause of free speech coming to be seen as the property of the right, making many on the left even more wary of the idea.
One of the ironies, though, is that many arguments used today to defend speech restrictions as protections for the powerless are often the same as those once used by the powerful to protect their interests from challenge. When the US abolitionist newspaper editor Elijah Lovejoy was murdered in 1837 by a pro-slavery mob in Illinois, a southern newspaper blamed him for his own death, as he had utterly disregarded the sentiments of a large majority of the people of that place. A century and a half later, we heard the same arguments in calls for the banning of The Satanic Verses or in claims that the Charlie Hebdo cartoonists were responsible for their own deaths, because they, too, had disregarded the sentiments of many Muslims.
Or take hate speech. In the 1950s, there was a major debate about the wording of the International Covenant on Civil and Political Rights, one of the seminal documents of human rights, adopted by the UN in 1966. The draft proposal sought to prohibit any advocacy of national, racial or religious hostility that constitutes an incitement to violence. The Soviet Union wanted to delete the reference to violence and make any form of hatred illegal. Such a move, warned Eleanor Roosevelt, chair of the drafting committee, would be extremely dangerous as any criticism of public or religious authorities might all too easily be described as incitement to hatred and consequently prohibited. Half a century on, Roosevelts warning seems highly prescient.
Instances in which the expansion of speech has facilitated the spread of obnoxious or dangerous ideas are well-documented: from the newly invented printing press giving fuel to witch-hunts in early modern Europe; to newspapers playing a major role in whipping up the racist frenzy that led to lynchings in 19th-century America; to the medias role in the 20th century in fomenting hatred against Jews in Germany and Tutsis in Rwanda.
Yet we can also see from the historical record that while it is necessary to legally curtail incitement to violence, trying to combat hatred more broadly through censorship can be both ineffective and dangerous. One of the deepest-held beliefs about the dangers of free speech is the Weimar myth: the belief that unrestrained freedom of speech allowed the Nazis to spread their poisonous ideas in 1920s Germany and that restrictions on speech and the suppression of antisemitic propaganda would have stalled the rise of Hitler. In fact, the Weimar republic, while constitutionally supportive of free speech, possessed what we would now call hate speech laws and powers to shut down newspapers. Hundreds of Nazis were prosecuted under these laws. Between 1923 and 1933, the viciously antisemitic newspaper Der Strmer was either confiscated or tried in court on 36 occasions and its editor, Julius Streicher, twice jailed.
Many scholars argue that despite such laws Weimar courts were unduly lenient towards hate-mongers and that judges sympathised with Nazi aims. Other studies suggest that such leniency was the exception, not the rule. Wherever the truth lies in this debate, the primary failure in preventing the rise of Nazism was not legal but political. And this is true of hatred and bigotry today.
We often forget, too, that the victims of censorship are more often than not minorities and those fighting for social change. From Indian climate change activists being charged with promoting enmity between communities to British police charging feminists with hate crimes, censorship in the name of preventing hatred is widely used to target social activists.
We are the inheritors of centuries of struggle against restrictions on what we are able to say. If we forget the lessons of those struggles, we are in danger also of letting the gains of those struggles slip away.
Kenan Malik is an Observer columist
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President of Seychelles, Somalia Arrive in Addis Ababa to Partake in AU Summit – Satenaw Ethiopian News/Breaking News | Your right to know!
Posted: at 5:15 am
Addis Ababa February 4/2022/ENA/ The Presidents of Seychelles and Somalia have arrived in Addis Ababa today to participate in the upcoming AU summit.
Up on arrival at the Addis Ababa Bole International Airport, the President of Seychelles, Wavel Ramkalawan and President of Somalia, Mohamed Abdullahi Mohamed were warmly welcomed by Minister of Transport, Dagmawit Moges, Minister of a Agriculture, Omer Husein, State Minister of Foreign Affairs, Ambassador Birtukan Ayano and other high level government officials.
After a two year interruption due to COVID-19 pandemic, the African Union Heads of State and Government are arriving in Addis Ababa to attend the 35th Ordinary Session of AU summit scheduled to kick off tomorrow.
The 40th ordinary session of AU Executive Council was held for the past two days here in Addis Ababa to propose various agenda items to the AU Summit for further discussion.
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State Board of Regents to announce required free speech training – UI The Daily Iowan
Posted: at 5:15 am
The state Board of Regents will announce a new free speech training module via email from President Mike Richards on Wednesday. The training will be required for all members of the University of Iowa and other regent institutions and has to be completed before the end of the spring semester.
University of Iowa students, staff, and faculty will need to complete a free speech training by the end of the spring semester, President Barbara Wilson announced in an email on Tuesday.
Wilson wrote that all members of the university community will receive an email on Wednesday from Mike Richards, the state Board of Regents President, and Greta Rouse, chair of the regents Free Speech Committee, announcing the release of the new free speech training module. The training will be administered to all three public universities in Iowa, including Iowa State University and the University of Northern Iowa.
All faculty, staff, and students are expected to complete the training prior to the end of the spring 2022 semester, the announcement reads. This training is required by Iowa law, is being provided on all three university campuses, and is important to our efforts in educating the campus community about First Amendment rights to free expression.
The training module will be online and will take 15 to 20 minutes to complete, the email reads.
The regents have implemented several freedom of speech-based policies in the last two years. In 2020, the regents created the free speech committee to study the issue and evaluate implementation of its 2019 free speech policy.
The regents also sent out a free speech survey to the universities in November, asking respondents to rank various statements based on their level of agreement.
Free speech issues in higher education were a central focus of Republican lawmakers during the 2021 legislative session. The House Government Oversight Committee held hearings on a student who said he was threatened with discipline for remarks made in a College of Dentistry email thread, and the Legislature passed multiple bills relating to free speech on campus.
A 2021 Knight Foundation study, released this January, found that students views on the security of free speech fell 12 percentage points between 2019 and 2021. The study also found that people of color on campuses feel less protected by the First Amendment.
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State Board of Regents to announce required free speech training - UI The Daily Iowan
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Knoxville man accused of trying to help ISIS terrorists says his actions are protected under freedom of speech – WBIR.com
Posted: at 5:14 am
In a low-resolution video interview from the Knox County Jail, Benjamin Carpenter said he plans to beat the charges at his federal trial this summer.
KNOXVILLE, Tenn. A Knoxville man accused of trying to help ISIS terrorists said he plans to argue his actions are protected under the First Amendment when he represents himself in a federal court trial this summer, he told 10News.
In a series of interviews from the Knox County Jail, Benjamin Carpenter, 31, said he has no regrets and does not consider himself a terrorist though he does admit support for the Islamic State terrorist group, which has claimed responsibility for shootings, bombings and beheadings.
"I have no qualms of being described as pro-Islamic State," he said. "Because we share the same kind of methodology and outlook."
In March 2021, federal agents arrested Carpenter while he was working as a dog-walker. Prosecutors said he agreed to assist an undercover FBI agent to transcribe and translate a 25-minute ISIS video titled "Bleeding Campaigns."
The video "documents ISISs military operations against Egyptian troops, including ISIS fighters engaging in battle, executing a suicide bombing, and capturing and executing three individuals," court documents showed.
He faces charges that the translation was an attempt to provide material assistance to the terror group.
"It's simply not a crime what they're accusing me of," Carpenter said.
He said he helped run a pro-ISIS website and regularly translated material for it. "Its similar to what weve done previously," he said of the Bleeding Campaigns video. "The Islamic state would release something in Arabic and I would find it beneficial and I would translate it."
"[The website's] stated goal was to spread the Islamic creed, a methodology, and not watering that down for anybody," Carpenter said. "And if that happens to support individuals overseas so be it."
While Carpenter's views may be repugnant to many people's beliefs in East Tennessee, translating the video isn't a crime said defense attorney T. Scott Jones.
"Its a question of whether or not you materially assisted a terrorist organization and thats going to be a question for the judge and ultimately one for the jury to decide," said Jones, who is not connected with the case. "Unless he did some overt act other than just translating, I think the government is going to have a hard row to hoe, so to speak."
But a former federal prosecutor who reviewed the case said there's likely more to the charges that have not yet been unsealed or declassified. Speaking on background because he did not have inside knowledge of the case, he said the U.S. Attorney's Office rarely brings cases unless prosecutors are confident they can win.
"God Molded Me Into What I am Today"
Carpenter attended Bearden Middle School and West High School, before moving to Myrtle Beach his senior year, he said. He wasn't raised as a practicing Muslim. Later in life, he converted and began to subscribe to radical philosophies.
"I was kind of molded over a series of events and learning and gaining knowledge," he said. "Eventually God just molded me into what I am today."
By May 2015 he was on the FBI's radar and agents searched his home in Virginia, where Carpenter lived with a girlfriend and worked as a bread baker, court documents reveal.
At the time, he told FBI agents he believed the attacks on Sept. 11 were justified and, in 2016, said U.S. citizens should "expect to be victims of an attack," prosecutors said.
Since then, Carpenter said he's been prepared for federal authorities to arrest him.
"I kind of knew that the government would try to snag me at some point," he said. "They've been trying to get me since 2015."
He moved back to East Tennessee around 2-and-a -half years before his arrest, his mother, Denise Carpenter, told a federal judge. She assured the court in spring 2021 she would make sure Carpenter followed release rules and showed up for future appearances if allowed out of jail while he waited for a trial.
She testified he does not have a bank account and worked only 10 hours per week at a pet sitting service.
Prosecutors said Carpenter used his mother's University of Tennessee issued computer to write a blog post for the pro-ISIS website they allege he operated.
Federal magistrate judge Debra Poplin denied the requestto release him, citing a "gave danger to both the local and international communities."
"His faith in Islam and trust in God keeps him humble and give him strength to be willing and able to see and give his best in his current circumstance," Denise Carpenter wrote in a text to 10News. "Would he rather he have his freedom? Of course, as would his family, who misses him greatly."
Federal prosecutors said Carpenter grew "more and more prolific" after his 2015 run-ins with the FBI.
Prosecutors submitted more than two dozen exhibits to the court including videos, articles on beheadings and weapons of mass destruction, accusing Carpenter of "Jihad with a pen."
"I'm a regular person, not violent per se," Carpenter told 10News. He denied ever planning or participating in violence. "If I did, the government would surely know about it."
Still, he said he supported most violence perpetrated by the Islamic State.
"Some you would disagree with," he said. "Just like an American would disagree with some attacks, but they would maybe agree with the certain war that goes on."
In court transcripts, prosecutors said Carpenter talked with other ISIS sympathizers online and praised the Nashville Christmas Day bombing. When asked by 10News, he expressed support for the 9/11 attacks.
"They're definitely justified," Carpenter said.
Beaten back by international militaries, East Tennessee State University Terrorism Scholar Paul Kamolnick said ISIS relies on supporters like Carpenter to survive and spread their ideologies.
"What theyve been reduced to is basically a strategy of individualized terrorism," he said, saying they rely on the internet and online translations to spread propaganda. "That's the only way they reach audiences."
"God willing, I'll be found not guilty"
Prosecutors put it more bluntly; "The defendant supports ISIS-inspired violence, praises ISIS-inspired violence and believes violence is justified in furtherance of jihad," they wrote in court documents.
But Carpenter believes the U.S. Constitution protects him under the first amendment, guaranteeing him freedom of speech. He said he's been preparing for years to represent himself, expecting he would get arrested.
In handwritten federal court filings, he argues his conduct translating documents doesn't rise to the level of "material support" for ISIS. He argues that the court needs to take into consideration the alleged conduct of the act of terrorism.
"The alleged conduct [...] revolves around editing a translation clearly not what an ordinary person thinks of when 'a federal crime of terrorism' comes to mind," he wrote.
"God willing, and with his permission, [the case] will be dismissed and thrown out. If it makes it to trial, God willing Ill be found not guilty," Carpenter told 10News.
He said he's not worried if he is found guilty and sentenced to the maximum possible penalty 20 years in federal prison.
"I can worship God inside a jail or outside a jail. If God wills for me to be in jail, he wills for me to be in jail," he said.
Carpenter's case is scheduled for a jury trial in late August.
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Republican committee members force vote on anti-critical race theory bill – The Daily Times
Posted: at 5:14 am
CHARLESTON Members of a House of Delegates committee approved a bill Thursday to provide more curriculum transparency and limit the teaching of anti-racism concepts commonly labeled as Critical Race Theory while also ending further discussion and amendments to the bill.
The House Education Committee recommended House Bill 4011 Thursday afternoon in a 18-5 roll call vote. The bill now heads to the House Judiciary Committee.
The committee heard nearly two hours of questions from its counsel, a representative for the Department of Education, and the bills lead sponsor, Delegate Chris Pritt, R-Kanawha. But Delegate Caleb Hanna, R-Nicholas, made a motion to call the previous question on the strike-and-insert amendment, which cuts off all debate, and move the bill.
Will this mean the bill will come out of the committee with no formal debate whatsoever, no opportunity for the minority to make its case in debate, asked Delegate John Doyle, D-Jefferson.
Through this process, have we eliminated any opportunity to offer amendments to the amendment, asked committee minority Vice Chairman Cody Thompson.
If you vote it down, then you have the chance to offer amendments, said committee Chairman Joe Ellington, R-Mercer.
HB 4011, also called the Anti-Stereotyping Act, would require schools to post all training materials and curriculum online pertaining to non-discrimination, diversity, equity, inclusion, race, ethnicity, sex, bias, or any combination of those concepts.
The bill would prohibit the promotion or endorsement by school employees and county school boards of stereotypes based on race, sex, ethnicity, religion, or national origin. The bill would not prohibit the discussion of how stereotypes have been used to discriminate or data that reveals disparities between categories of people based on race, sex, ethnicity, religion, or national origin.
In a section, labeled Preservation of Freedom of Speech, the bill would prohibit schools and county board of education officials from compelling students and staff to adopt any belief or concept that one race, sex, ethnicity, religion, or national origin is inherently superior or inferior to another. It states that no person should be blamed for the action committed in the past by someone of the same race, sex, ethnicity, religion, or national origin.
The bill would prohibit public funds from being used to pay for anti-racism and racial equity consultants or require students and staff to attend any sessions with such consultants, though it does protect voluntary attendance.
According to the Manhattan Institute, a conservative think tank that offers model legislation similar to HB 4011, 25 states have introduced bills aimed at limiting the teaching of philosophies based in part on Critical Race Theory.
Opponents of CRT say it teaches racism is systemic in American systems of government and institutions with white people inherently benefiting from these systems at the expense of marginalized minorities, such as Black people or the LGBTQ community.
Under questioning, Pritt told committee members that he was unaware of any specific instance in West Virginia where philosophies based on CRT are being taught in West Virginia.
Just because we cant cite a specific instance doesnt mean its not happening, Pritt said. Our jobs as legislators is to be proactive, not to react to everythingI cant give you the specifics on one particular issue.
Instead of protecting free speech rights, opponents of these kinds of anti-CRT and anti-racism bills, such as the West Virginia chapter of the ACLU, believe this legislation hinders freedom of speech and stifles discussion of complicated topics, such as racial injustice, discrimination, civil rights, and slavery.
This bill is designed to intimidate teachers from discussing diversity and equity, the ACLU-WV posted on Twitter. We need to teach issues like race the same way we teach math and science: as accurately as possible.
Delegate Ric Griffith, D-Wayne, said he was concerned about the unintended consequences of the bill. He said the bill could limit discussion of historical topics in schools.
Where does history and opinion overlap, Griffith asked. I can see there would be some gray areasalmost all questions require an opinionespecially in history. Is it a possibility that this could stir a pot that could boil?
(Adams can be contacted at sadams@newsandsentinel.com)
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Religious speech on trial in Finland | WORLD – WORLD News Group
Posted: at 5:14 am
During a nearly nine-hour trial last week, a Finnish prosecutor laid out the case against politician Pivi Rsnen and Lutheran Bishop Juhana Pohjola, who are on trial for expressing their Biblical beliefs about homosexuality.
In April 2021, Finlands Prosecutor General Raija Toiviainen charged Rsnena 62-year-old medical doctor, longtime Finnish member of parliament, and former interior ministerwith ethnic agitation. Rsnens past statements on homosexuality were likely to fuel intolerance, contempt, and even hatred toward homosexuals and thus oversteps the boundaries of freedom of speech and religion, the prosecutors office said in a statement.
The charges relate to three instances of Rsnen expressing Biblical and personal views on homosexuality. In a 2019 Twitter post, she attached a picture of the Biblical text in Romans 1:24-27 and denounced the Evangelical Lutheran Church of Finland (ELCF), one of the countrys two national churches, for partnering with a local LGBT Pride event. The charges also target remarks she made on a nationally syndicated Finnish public radio program and a 23-page booklet she released in 2004 titled, Male and Female He Created Them.
Pohjola, 49, faces charges for publishing Rsnens booklet through the Luther Foundation Finland, a ministry arm of the Evangelical Lutheran Mission Diocese of Finland. The small group of conservative congregations formed after a 2013 split from the ELCF, in part over the denominations acceptance of homosexuality and transgenderism.
The case against Rsnen and Pohjola has attracted widespread international attention. The International Lutheran Council, a worldwide association of confessional Lutherans, protested the unjust treatment of Rsnen and Pohjola and called the actions of the Finnish prosecutors egregious. A citizens petition supporting Rsnen has garnered more than 335,000 signatures.
Alliance Defending Freedom International, the legal group representing Rsnen and Pohjola, said a ruling against them would not establish an immediate legal precedent for other European countries. It would, however, set a new low bar for European free speech standards, said Lois McLatchie, a representative from ADF International. Five U.S. lawmakers urged Rashad Hussain, the U.S. ambassador for international religious freedom, to monitor the case. They argue it could open the door for prosecution of other devout Christians, Muslims, Jews, and adherents of other faiths for publicly stating their religious beliefs that may conflict with secular trends.
Rsnen and Pohjola face a maximum sentence of two years imprisonment. The trial resumes on Feb. 14, and a verdict is expected to follow within a month. The prosecutor ordered fines for Rsnen, Pohjola, and the Luther Foundation. She also asked for Rsnens writings and statements to be removed from the internet, including the distribution of her booklet on the Luther Foundations website.
The booklet, intended for Lutheran laity, emphasizes that the Christian concept of humanity recognizes everyones inherent value, regardless of their sexual orientation. It characterizes same-sex partnerships as conflicting with Gods design for marriage and sex and sinful according to Scripture. Rsnen suggested homosexual tendencies are a result of a disorder of psycho-sexual development. On this point, Rsnen said during the trial that some information in the pamphlet is outdated since research and legislation have changed. Still, she argued it usefully reflects discussions taking place at the time. Censorship would open the floodgates to a ban on similar publications, Rsnen told WORLD.
Pohjola expressed similar concern. What worries me is if [the prosecutors] arguments are considered valid, thats a radical shift in the understanding of freedom of religion, he said. As a Lutheran bishop, I have no other way of teaching. We have to make a basic distinction between the value of human beings and judging our acts in light of the Word of God.
Rsnen, a pastors wife, mother of five, and grandmother of seven, clutched a Bible as she entered the court on Jan. 24. She called it an honor to defend freedom of speech and religion and vowed to continue fighting if the case reaches higher courts, including the European Court of Human Rights.
Following the proceedings, Rsnen sent an email to supporters saying she was relieved the long-awaited and heavy day was over. She said she waits for the verdict with a calm and hopeful mind.
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Cytiva and NecstGen Collaborate on Development of Cell and Gene Therapies – Genetic Engineering & Biotechnology News
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Cytiva and NecstGen say they plan to accelerate the development of new cell and gene therapies globally by entering into a strategic collaboration. Cytiva will provide its technologies, services, and solutions to NecstGen, and both organizations will share their knowledge and expertise as research programs are translated into next generation therapies, according to officials at both companies.
Cell and gene therapies are transformative medicines and accelerating their development requires harnessing the power of the industry, says Catarina Flyborg, vice president, cell and gene therapy, Cytiva. By sharing our expertise and providing NecstGen with access to our team of specialists, Cytiva will play a critical role in taking translational research from the laboratory to the bedside.
NecstGen is a non-profit contract development and manufacturing organization (CDMO) specializing in cell and gene therapies in the Netherlands. It brings the development, production, QC, QA, and QP functions together in a new 4,000 m2 facility in Leiden Bio Science Park, the largest bio-cluster in the Netherlands, notes Paul Bilars, CEO, NecstGen.
The new facility is designed to serve all organizations worldwide, particularly academic and small/large industry enterprises that are looking to bring their research to the clinical stage. NecstGen will provide process development, cGMP manufacturing services up to 200L, and cleanroom rental.
Our partnership with Cytiva will provide us with the flexible and scalable solutions needed by pioneers in the field of cell and gene therapy, says Bilars. Working together, we will accelerate the development of future therapies, bringing these to patients faster.
During the first half of 2021, there were 1,328 regenerative medicine trials underway globally sponsored by non-industry groups such as academic centers and government entities, according to the Alliance for Regenerative Medicine. Small and mid-size enterprises and academic centers play an important role in the development of novel cell and gene therapies.
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Cytiva and NecstGen Collaborate on Development of Cell and Gene Therapies - Genetic Engineering & Biotechnology News
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Researchers solve medical mystery of deadly illness in young child Washington University School of Medicine in St. Louis – Washington University…
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Cross-disciplinary team identifies genetic cause of rare, undiagnosed lung disease
New research from Washington University School of Medicine in St. Louis has solved the medical mystery of why a 2-year-old child seemingly healthy at birth succumbed to an undiagnosed, rare illness. On the left is normal lung tissue showing air sacs with thin cell layers for the exchange of oxygen and carbon dioxide. On the right is the patient's lung tissue. Because of a mutation in the RAB5B gene, the walls of the air sacs are thick and unable to participate in gas transfer.
New research from Washington University School of Medicine in St. Louis has solved the medical mystery of why a 2-year-old child seemingly healthy at birth succumbed to an undiagnosed, rare illness. The research team identified a previously unknown genetic cause of interstitial lung disease, providing answers to the parents and doctors puzzled by the childs condition.
The research, conducted as part of the National Institutes of Healths (NIH) Undiagnosed Diseases Network, demonstrates, among other benefits, how an interdisciplinary team of researchers can work together to solve medical mysteries, helping patients understand a diagnosis, prognosis and what a genetic abnormality may mean for family members and family planning.
The study is published the week of Jan. 31 in the Proceedings of the National Academy of Sciences. The Undiagnosed Diseases Network is a national research network aimed at diagnosing rare and previously undescribed diseases in patients whose conditions present as medical mysteries. Washington University serves as a clinical site that evaluates patients, and a model organism screening site that develops models to study genes in zebrafish and roundworms.
Interstitial lung disease is a broad term for a disease in which the lungs gradually deteriorate, causing scarring that makes it increasingly difficult to breathe. Several gene abnormalities have been associated with interstitial lung disease in infants and children, but some patients have the disease despite harboring none of the known genetic abnormalities. In the new study, the researchers were presented with the case of a young child with interstitial lung disease of unknown cause. The child later died of the disease.
The researchers analyzed the childs DNA code as well as the DNA code of both parents. A team of bioinformatics specialists at Baylor College of Medicine then narrowed down the initial long list of DNA code changes or genetic variants they identified many of which are harmless to a smaller list of possible culprits. The lung tissue from the child had evidence of a problem with surfactant in the lungs. In the lungs air sacs, surfactant is a complex mixture of proteins and lipids that reduces surface tension in the air sacs and keeps them open, easing the exchange of oxygen and carbon dioxide during breathing. Many people with interstitial lung disease have abnormalities in the surfactant protein genes. But this child did not have any genetic variants in the code of the surfactant protein genes.
Rather, the researchers found a variant in a gene that makes a protein called RAB5B that turns out to be part of the cellular machinery that processes the surfactant proteins, the researchers later learned. They showed that the RAB5B protein plays a vital role in packaging the surfactants into tiny compartments called vesicles and moving them to their proper locations. In this case, the genetic variant did not simply prevent the protein from working the genetic variant caused the protein to be actively harmful.
When mutations happen that break a protein, usually the protein just doesnt work anymore its function is missing, said co-senior author Tim Schedl, PhD, a professor of genetics. But this is a case where the broken protein is not only not working, its actively poisoning other processes. This results in the loss of the surfactants in the lungs.
The researchers were able to identify this abnormality by studying the genetic variant in roundworms that are called C. elegans. The child had only one abnormal copy of the gene, demonstrating that even having one normal copy did not compensate for the poisonous protein produced by the mutated copy. Worms with one abnormal copy required three normal copies to restore normal function, demonstrating the poisonous activity of the abnormal copy, according to experiments conducted by first author Huiyan Winnie Huang, PhD, an instructor in pediatrics. And consistent with these genetics, the researchers found that neither of the childs parents had the genetic abnormality, indicating that the variant was only present, by happenstance, in the childs genes and was therefore a new variant in the DNA that arose during embryonic development.
In so many cases, we dont know why a patient has a particular disease, said co-senior author Steven L. Brody, MD, the Dorothy R. and Hubert C. Moog Professor of Pulmonary Medicine. But we were able to solve this case, and theres a real satisfaction in that. Potentially, this could lead to finding answers for other people who have diseases similar to this.
Added co-author Jennifer A. Wambach, MD, an associate professor of pediatrics: This gene, RAB5B, is now associated with interstitial lung disease in children. There are patients with a clinical diagnosis of interstitial lung disease without a genetic explanation. For these patients, sequencing RAB5B may reveal changes in their DNA code that could account for their disease. Knowing the underlying genetic cause and identifying other patients with the same genetic problem can help us better predict the course of the disease, so we can better prepare patients and their families for what is to come, such as whether the patient may respond to treatments, or worsen to needing a lung transplant, or whether it may be appropriate to begin discussing compassionate care.
While the diagnosis was not able to help the patient in this case, knowledge of the underlying cause allowed the parents to know that the genetic variant was not inherited and there would be a very low chance of future children having the same disease.
Because these types of genetic diseases are so rare, theres very little information out there for patients or families, said co-senior author Stephen C. Pak, PhD, an associate professor of pediatrics. But collectively, there are millions of people who live with rare genetic diseases. Thats why the Undiagnosed Diseases Network was formed to bring together bioinformatics specialists, researchers, lung biologists, pediatricians and other experts into this type of unique collaboration to try and address this unmet need.
This work was supported by the National Institutes of Health (NIH) Common Fund, through the Office of Strategic Coordination/Office of the NIH Director, grant numbers U54 NS108251 and U01 HG007709. Funding also was provided by the NIH, grant number R01 GM100756; the NIH Office of Research Infrastructure Programs, grant number P40 OD010440; the National Heart, Lung, and Blood Institute (NHLBI) of the NIH through the LungMAP consortium, grant number U01HL122642, and the LungMAP Data Coordinating Center, grant number 1U01HL122638; the Childrens Discovery Institute; the St. Louis Childrens Hospital Foundation; and The Foundation for Barnes-Jewish Hospital.
Huang H, et al. A dominant negative variant of RAB5B disrupts maturation of surfactant protein B and surfactant protein C. Proceedings of the National Academy of Sciences. Jan. 31, 2022.
Washington University School of Medicines 1,700 faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Childrens hospitals. The School of Medicine is a leader in medical research, teaching and patient care, and is among the top recipients of research funding from the National Institutes of Health (NIH). Through its affiliations with Barnes-Jewish and St. Louis Childrens hospitals, the School of Medicine is linked to BJC HealthCare.
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Researchers solve medical mystery of deadly illness in young child Washington University School of Medicine in St. Louis - Washington University...
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