The Prometheus League
Breaking News and Updates
- Abolition Of Work
- Ai
- Alt-right
- Alternative Medicine
- Antifa
- Artificial General Intelligence
- Artificial Intelligence
- Artificial Super Intelligence
- Ascension
- Astronomy
- Atheism
- Atheist
- Atlas Shrugged
- Automation
- Ayn Rand
- Bahamas
- Bankruptcy
- Basic Income Guarantee
- Big Tech
- Bitcoin
- Black Lives Matter
- Blackjack
- Boca Chica Texas
- Brexit
- Caribbean
- Casino
- Casino Affiliate
- Cbd Oil
- Censorship
- Cf
- Chess Engines
- Childfree
- Cloning
- Cloud Computing
- Conscious Evolution
- Corona Virus
- Cosmic Heaven
- Covid-19
- Cryonics
- Cryptocurrency
- Cyberpunk
- Darwinism
- Democrat
- Designer Babies
- DNA
- Donald Trump
- Eczema
- Elon Musk
- Entheogens
- Ethical Egoism
- Eugenic Concepts
- Eugenics
- Euthanasia
- Evolution
- Extropian
- Extropianism
- Extropy
- Fake News
- Federalism
- Federalist
- Fifth Amendment
- Fifth Amendment
- Financial Independence
- First Amendment
- Fiscal Freedom
- Food Supplements
- Fourth Amendment
- Fourth Amendment
- Free Speech
- Freedom
- Freedom of Speech
- Futurism
- Futurist
- Gambling
- Gene Medicine
- Genetic Engineering
- Genome
- Germ Warfare
- Golden Rule
- Government Oppression
- Hedonism
- High Seas
- History
- Hubble Telescope
- Human Genetic Engineering
- Human Genetics
- Human Immortality
- Human Longevity
- Illuminati
- Immortality
- Immortality Medicine
- Intentional Communities
- Jacinda Ardern
- Jitsi
- Jordan Peterson
- Las Vegas
- Liberal
- Libertarian
- Libertarianism
- Liberty
- Life Extension
- Macau
- Marie Byrd Land
- Mars
- Mars Colonization
- Mars Colony
- Memetics
- Micronations
- Mind Uploading
- Minerva Reefs
- Modern Satanism
- Moon Colonization
- Nanotech
- National Vanguard
- NATO
- Neo-eugenics
- Neurohacking
- Neurotechnology
- New Utopia
- New Zealand
- Nihilism
- Nootropics
- NSA
- Oceania
- Offshore
- Olympics
- Online Casino
- Online Gambling
- Pantheism
- Personal Empowerment
- Poker
- Political Correctness
- Politically Incorrect
- Polygamy
- Populism
- Post Human
- Post Humanism
- Posthuman
- Posthumanism
- Private Islands
- Progress
- Proud Boys
- Psoriasis
- Psychedelics
- Putin
- Quantum Computing
- Quantum Physics
- Rationalism
- Republican
- Resource Based Economy
- Robotics
- Rockall
- Ron Paul
- Roulette
- Russia
- Sealand
- Seasteading
- Second Amendment
- Second Amendment
- Seychelles
- Singularitarianism
- Singularity
- Socio-economic Collapse
- Space Exploration
- Space Station
- Space Travel
- Spacex
- Sports Betting
- Sportsbook
- Superintelligence
- Survivalism
- Talmud
- Technology
- Teilhard De Charden
- Terraforming Mars
- The Singularity
- Tms
- Tor Browser
- Trance
- Transhuman
- Transhuman News
- Transhumanism
- Transhumanist
- Transtopian
- Transtopianism
- Ukraine
- Uncategorized
- Vaping
- Victimless Crimes
- Virtual Reality
- Wage Slavery
- War On Drugs
- Waveland
- Ww3
- Yahoo
- Zeitgeist Movement
-
Prometheism
-
Forbidden Fruit
-
The Evolutionary Perspective
Monthly Archives: February 2022
When I recall my father Elie Wiesel, my shame about these Olympics only deepens – thejewishchronicle.net
Posted: February 17, 2022 at 7:47 am
On Friday, Feb. 4, my world was shaken. It hit me as though it were a fresh wound: My father, Elie Wiesel, was really gone.
It hurt terribly when he died over five years ago, on July 2, 2016. But I also found peace and awakening as I grieved. I had this sense from the very moment he passed that he would be with me always. Through his dreams for me, I felt that as long as I lived, he would too as would my ancestors.
This feeling deepened over the years that followed. My year of Mourners Kaddish ended and I still found myself drawn to Shabbat peace, to morning tefillin, to the intentionality of a minyan gathered to pray, to the stories of our people in ancient texts. I felt the wholeness of history, of the chain of which he had always wanted me to feel a crucial part, which he so keenly felt himself. And although I miss him daily, I unfailingly find that thinking of him makes my footsteps feel sure.But on Feb. 4 I had to stop and catch my breath as I realized the depth of my loss, our loss.
Get The Jewish Chronicle Weekly Edition by email and never miss our top storiesFree Sign Up
Because that day was the opening of the Beijing Winter Olympics, and millions were tuning in to the opening ceremony. Most of the world didnt seem to know, or care, that the host country is hosting a pageant of peace and friendship while simultaneously terrorizing its Uyghur minority.
The Chinese governments systematic oppression of the Uyghurs, a Muslim group in northwest China, is not the Holocaust. But although we may not have seen this particular movie, we know the genre.
I have heard the painful testimony of Uyghur dissidents, who manage to get the word out despite a media clampdown that makes it almost impossible for the Western press to report on the facts. Forced internment camps target people for thought crimes and racial affiliation. Medical data suggests that forced sterilizations are taking place among this targeted racial group. Families have been forcibly separated and threatened into silence.
Just like in 1936, the International Olympic Committee is unwilling to push the issue. And our community is mostly silent.I saw 100 or 200 brave souls rally on a rainy Thursday in Times Square. In the gray neon light, the young leaders called on each other and passersby via megaphones whose batteries could not keep up with the urgency of the message: Turn off the Olympics, and close the concentration camps in Xinjiang.
It should have been the whole city turning up to honor their message.
I know now that we have failed my father in this regard. He did not fail us. He spoke of how he always felt he had to answer to the dead: Did he do enough? And yes. He did.
He was there to speak up against atrocities in Darfur, Bosnia, Cambodia, Rwanda. He tried with everything he had to tell us. And all the words he spoke and wrote could not change the fact that five years after his death, 1 million people are reportedly in concentration camps, because of their race and religion, in the grip of a totalitarian regime a regime honored to host the worlds nations, on a global television platform that packages sports with advertising.
Todays culture of workplace activism is highly developed. In corporations and small businesses across the United States, Black Americans and their allies, for one, showed with emotion how cries against police brutality could be heard in board rooms and executive suites.
But are men and women of conscience reaching out to their managers at the corporations that sponsor the Olympics? Are voices inside corporate America respectfully but insistently calling for company conversations about their responsibility when they hear survivors reports of genocide on the part of the Chinese government? If they are, they are not making themselves heard.There are brave leaders, like Steve Simon of the Womens Tennis Association, who canceled a lucrative tournament in China when the WTAs demands for player Peng Shuais safety and freedom went unanswered. Natan Sharansky and Bernard-Henri Lvy, two leading Jewish intellectuals, signed an ad in The New York Times, organized by me and paid for by the Elie Wiesel Foundation, urging a protest of the Beijing Olympics; Jewish organizations across the denominational spectrum have spoken up for the Uyghurs; and Jewish World Watch is trying to generate widespread action around the issue.
But they are still too few. I fear that Chinas state-sponsored capitalism has silenced us through our greed.
My father believed passionately that speaking up mattered, especially to the victims.
Have I, blessed to live in this country which stands for freedom, done enough?
Shame on Xi Jinping, shouted the determined young people in Times Square on Thursday night.And I think: Shame on me, if we cant find some way to help. Shame on us.PJC
Elisha Wiesel is the son of Marion and Elie Wiesel. This piece first appeared on JTA.
View post:
Posted in Government Oppression
Comments Off on When I recall my father Elie Wiesel, my shame about these Olympics only deepens – thejewishchronicle.net
The liberal order is already dead – UnHerd
Posted: at 7:47 am
In the summer of 1990, I stood where the wall had been and wondered at what had happened to Europe. I wasnt alone: the rest of the city, the rest of the continent, was wondering too.
I was 18 years old, interrailing around Europe with a friend to see what the world looked like beyond our provincial English town, and I had accidentally wandered into a pivot point in history. In the divided German capital, less than a year before, World War Two had finally come to an end, with no shots fired.
The joy was palpable everywhere. By the time my friend and I got to the Brandenburg Gate, half of the wall had already been chipped into bite-sized pieces, which were being sold to tourists by enterprising locals, along with suddenly useless Soviet army uniforms, military passbooks and the helmets of East German border guards. Marxism hadnt been dead a year, and the market economy was already booming.The world, or the little part of it that I knew, had suddenly changed shape entirely.
Everyone of my generation grew up with the Cold War hanging over them. The possibility of nuclear armageddon was as ever-present for teenagers then as climate change is today: we didnt think about it much, but it was the background hum of our lives. Nobody thought the Russians would invade, really, but there didnt seem much chance of them going away either. There was always a chance of their tanks rolling across some border somewhere, or so the Americans kept telling us. Plus a change.
This was just the way the world was: the free West and the unfree East. If you didnt believe that story, then one look at the wall, the barbed wire, the machine gun towers and the fate of those who tried to cross the death strip from East to West would make you think again.
And then, just like that, communism fell. This system that was supposed to free the people from exploitation and oppression, but had quickly become a monster itself. We didnt know what was coming next. But from todays perspective we can see that the fall of the East ushered in a new era.
After the wall would come a unipolar world, dominated by finance capital, overseen by the United States of America, the last empire standing. Its architects told us we were entering a long age of benign globalisation, in which free markets, human rights and democracy would spread around the world as naturally as the sun rose in the morning. The future would be free, open, liberal, prosperous and, well, American.
30 years later, we live in a world in which most Russians have apositive view of Stalin, and their current leader is mustering the biggest army since Soviet times on the border of a neighbouring state. The once-free-ish West is boiling in a stew of hate speech laws, vaccine mandates and ever-accelerating censorship and intolerance. Populists continue to barrack and harass its leaders, who still have no idea what to do about it: witness Justin Trudeau running away from the big scary men in their lorries. The last global empire is led by a confused octogenarian, and within a few years the biggest economy in the world will be a communist dictatorship. We didnt see that one coming back in 1990.
Remembering the rubble strewn across Potsdamer Platz, its hard not to miss the End of History. In those halcyon days, I thought I lived in something called the free world. The liberal West was supposed to be the point on which the arc of history converged. We wanted it to be true, that story, but history has a habit of rolling on, and people dont change, not really. Im just grateful to have been there.
Looking back, we can see that what happened when the wall fell was not the triumph of freedom over oppression so much as the defeat of one Western ideology by another. The one that came through was the oldest, subtlest and longest-lasting, one which disguised itself so well that we didnt know it was an ideology at all: liberalism.
This was the thesis of Patrick Deneens 2018 book Why Liberalism Failed, written before the populist wave of 2016, and perhaps the most reliable guide to the world we live in now. In his telling, liberalism was one of three ideologies that dominated the world over the last three centuries. The other two communism and fascism were shorter lived, and died in the West in the twentieth century. Liberalism the elder brother is only dying now. One reason for its comparatively long life is that it piggybacked on older stories, presenting itself as the inheritor of established traditions of liberty when in fact it was something quite different.
The ideology of liberalism has, since it emerged from the Enlightenment, claimed to liberate the individual from oppression. In practice it has manifested as the process of breaking all borders, limits and structures: of bringing down walls. The societies we have built around this way of seeing claim freedomforthe individualfromsociety itself, and proffer a radical notion of human nature. Rather than seeing humans as hefted creatures, rooted in time and place, liberalism offered a new conception: detached, sovereign personhood. Humans were now rights-bearing individuals who could fashion and pursue for themselves their own version of the good life.
What is crucial to understand and this is what makes liberalism an ideology is that in order for the liberal world to come into being, it needed to becreated. Just as Marxist regimes attempted to destroy the traditional family, the church and private land ownership so that communism could materialise, so liberalism did not naturally evolve from previously existing arrangements. It needed to artificially create the sovereign individual from new cloth.
After the trauma of the Reformation, the Western nation-state took over the functions of the ailing Church, colonising for itself the sense of sacredness and obedience once demanded by religion. In thismigration of the holyour religious sensibility was redirected from its proper focus towards worldly political constructions, and this in turn laid the ground for the revolutions of the modern age.
Each of these upheavals, whether inJacobin France, Marxist Russia or Nazi Germany, failed to create the promised utopias. But they did have the effect of clearing away the traditional structures of the pre-modern era. And into the void rushed industrial capitalism the system which G. K. Chesterton called themonster that grows in deserts with its sensibility of control, measurement, utility and profit. Liberalism was, and remains, its nursemaid and press officer.
Liberalism, like its competitor ideologies, is in this waytotalitarian: ruthless and all-encompassing. But it outlasted its rivals because it promised not tyranny and order, but the messiness of a certain kind of freedom. At the height of the liberal age, in the nineteenth and twentieth centuries, individual human freedom was indeed possible in the West as it had never been before. Humans, or some of them, could detach themselves from their backgrounds and origins and seek something new, and plenty of us did. Openly tyrannical government became harder to sustain, oligarchies were required to subject themselves to regular plebiscites to sustain their power, previously ignored groups in society clamoured for access to its heartlands, the rule of law protected the poor as well as the rich, and capitalisms Luciferic power created previously unheard of levels of wealth, as well as grinding poverty.
But in liberalisms very success lay the seeds of its failure. The project of liberating the individual from his or her networks of loyalty, locality, family and culture, and the unleashing of the vast destabilising engine of capitalism, created a social instability which could only be controlled or directed by the last institution standing: the State.
An ideology premised on protecting and promoting the freedom of the individual led to the era of unprecedented state power we live in today. Governments now claim the right to direct our speech patterns, regulate our lives and businesses to increasingly radical degrees, shut down whole societies in the name of public health, and even legislate for acceptable and unacceptable attitudes and opinions.
The cultural ructions of todays West the cancellations and contradictions, the screaming matches over race, gender, history and identity all of this is the manifestation not of liberalisms failure but of its success. The progressives who are aggressively cramming identity politics into every crevice of society have met with resistance from many self-professed liberals.These woke radicals,they cry,are destroying our culture with their fanaticism! We need to return to classical liberalism! But culture wars happen when no real culture remains; and 200 years of classical liberalism, manifested in the economic and the cultural spheres, have seen to that.
This is the legacy of an ideology which has been championed for centuries by both Left and Right. We have all become islands of self-definition, and we see now where that leads. A society premised on freedom becomes daily more fearful and closed. A society which boasts of its diversity becomes daily more homogenous. We can invent our own gender at will, and yet genuine individuals are in short supply, old-fashioned eccentricity is positively persecuted and originality has become career-ending. The Internet has enabled self-expression on a previously unimagined scale, and the result has been violent groupthink. The self, it turns out, mostly doesnt have much to say.
But theres more. Liberal ideology, as well as redesigning culture, must also redesign nature. In all the discussions of liberalism and its discontents that weve seen in the last few years, few seriously consider the power source that allowed the liberal age to conquer all before it: fossil fuels.
Without steamships, cars, planes, factories, supermarkets, modern roads, the Internet, the smartphone, the project of liberation would have been much less far-reaching. Fossil-fuelled liberalism allowed people to abandon place-based community, and to create for themselves an individual identity in an isolated but free kingdom of the self. But as the historian Dipesh Chakrabarty puts it, the mansion of modern freedoms stands on an ever-expanding base of fossil fuel use. Everything from mass democracy to feminism to multiculturalism to human rights floats on a vast bubble of fossil energy: . Nothing about the modern West could exist at all without vast concentrations of fossil energy: a fact of which Mr Putin is well aware.
Liberalism, like modernity itself, requires a war against nature; but it is a war that can never be won. As the climate shifts in response, the excesses of liberalism, and the project of self-creation it enabled, will not be possible. We will no longer be able to outsource our muscles or our minds to technology. We will need each other again whether we like it or not.
So what comes after liberalism? The question has filled plenty of column inches in recent years, but the Covid years have brought into sharp relief the likely future we face. In Why Liberalism Failed, Deneen predicts that two post-liberal worlds are on offer: a future of self-limitation, in which people choose to practice self-governance in local communities, or a future in which extreme licence coexists with extreme oppression.
I know which Id prefer, but I also know which looks most likely. As extreme individualism deepens, and an all-powerful state intervenes ever more deeply and widely to manage the resulting fragmentation, Western democracies show every sign of transforming openly into authoritarian oligarchies in which dissent especially dissent aimed at liberalism itself is ruthlessly suppressed by politicians who claim to represent the people. The vast bulks of those stationary Canadian trucks are currently the perfect symbol of this process.
The immediate future looks to me like the grinding down of what previous norms remain, and the parallel expansion of the State-corporate leviathan to both mop up the resulting mess and profit from it. That in turn will generate more populist (i.e. anti-liberal) reaction from both Left and Right and neither, and a consequent deepening of repression and propaganda from the besieged minority defending the remains of the liberal order. All of this will take place in the context of a planet with nearly ten billion people on it, hitting economic and ecological limits on all sides.
It seems likely to me that the liberal era will end much as the communist one did: flailing and corrupt, hiding behind walls of its own making, its leaders in denial but its people increasingly open-eyed. Perhaps the Russians wont roll into Ukraine and spell the end of the vaunted liberal order, but its end seems to have been baked in from the beginning. All ideologies are based on a view of human nature that looks better on paper than in the confusing mess of the world, and the one we grew up with was no exception. No man, as John Donne had it, is an island. Now we see how right he was.
A version of this essay was first published at The Abbey of Misrule.
See original here:
Posted in Government Oppression
Comments Off on The liberal order is already dead – UnHerd
Theres no solidarity in sovereign citizen protests only incoherent rage – The Guardian
Posted: at 7:47 am
When a group in black fatigues called Alpha Men Assemble began practising paramilitary manoeuvres in a park in Staffordshire at the beginning of this year, it looked pretty threatening. These men, we were warned, were about to launch an insurrection against vaccines and in favour of the sovereign citizen. Since then, silence. It wouldnt be surprising if the group had dispersed: a society of self-proclaimed alphas is bound to fall apart.
This was just one example of the incoherent protests now sweeping rich, English-speaking nations. Others include the truck blockade in Ottawa and its duplicates in Australia, New Zealand and the US, and the angry men outside the British parliament, waiting to pounce on passing politicians. By incoherent protest, I mean gatherings whose aims are simultaneously petty and grandiose. Their immediate objectives are small and often risible, attacking such minor inconveniences as face masks. The underlying aims are open-ended, massive and impossible to fulfil. Not just politically impossible, but mathematically impossible. Listening to these men (and most of them are men), it seems that every one of them wants to be king.
The sovereign citizen theory is a powerful current running through these movements. Its adherents insist that they stand above the law. Some of them refuse to buy vehicle licences, or pay taxes or fines. They believe they are exempt from public health measures, such as lockdowns and vaccine passes.
In other words, they arrogate to themselves sovereign powers that not even the monarch enjoys. They produce elaborate pseudo-legal documents to justify these claims. The memorandum of understanding published by two of the leading organisers of the Ottawa blockade, which makes impossible legal demands of the government, looks like a classic of the genre. It was supposedly signed by 320,000 people before the organisers withdrew it.
What explains the appeal of this movement? Such claims of individual sovereignty arose in the 1970s with an antisemitic, racist agitation called Posse Comitatus. They appear to surge in hard times. Some people believe they can annul their debts or tax arrears by renouncing their citizenship. But I suspect its about more than money. The promise of capitalism is that one day we will all be alphas just not yet. It is a formula for frustration and humiliation. The less equal the economic system becomes, the wider the gap between the promise and its fulfilment yawns. Humiliation, as Pankaj Mishra argued in his excellent book Age of Anger, is the motor of extremism. Noisy assertions of sovereignty look like an obvious attempt to overcome humiliation.
There was a time, in the rich nations, when it seemed as if we could all triumph. From the second world war until the late 1970s, general prosperity rose steadily. The top 1% captured a decreasing proportion of total income. But then, in the US, the UK, Canada, Ireland and Australia, the curve suddenly turned, and the 1% began to grab an ever greater share. The trend has continued to this day, sustained by the neoliberal doctrines that were first imposed in the rich world by Margaret Thatcher and Ronald Reagan.
The ultra-rich have gained most: since the beginning of the pandemic, the worlds 10 richest men have doubled their wealth, while 163 million people have been pushed below the poverty line. Wages for many people in the Anglosphere have stagnated, but the costs of living, especially housing, have soared.
But even during the glory years (1945 to 1975) the universal triumph capitalism promised was an illusion. The general rise of prosperity in rich nations was financed, in part, by poor ones. Decolonisation was resisted by the rich world with extreme violence and oppression, then partly reversed through coups and assassinations (such as the overthrow of Mohammad Mosaddegh in Iran in 1953, the crushing of Jacobo rbenzs government in Guatemala in 1954, the murder of Patrice Lumumba in Congo in 1961, Suhartos coup in Indonesia in 1967 and Augusto Pinochets in Chile in 1973). Today, such extreme measures are seldom required, as the transfer of wealth is secured by other means. The rich worlds wealth continues in large part to rely on the exploitation of black and brown people.
Incoherent protest movements tend to be infested with racism and white supremacy. Some of the key organisers of the Ottawa action are reported to have a grisly history of racist statements, and some of the protesters have flown swastikas and Confederate flags. When black and brown people assume positions of power and authority, and appear more alpha than those who expected tribute from them, this is perceived as an intolerable reversal. The current wave of incoherent protest began in the US with the reaction against Barack Obamas government, and soon evolved, with the encouragement of Donald Trump and others, into undisguised white supremacism.
Some of the Ottawa organisers also have a history of attacks on trade unions. The independence they demand means freedom from the decencies owed to other people, freedom from the obligations of civic life. In pursuing these selfish freedoms, they reinforce the neoliberal policies such as the crushing of organised labour that helped cause the impoverishment and insecurity suffered by those they claim to represent.
Canadian truckers, for example, especially immigrant workers, now suffer from wage theft, unsafe conditions and other brutal forms of exploitation, caused in part by a loss of collective bargaining power. But the protest organisers seem uninterested. Sovereignty and solidarity are not compatible.
More:
Theres no solidarity in sovereign citizen protests only incoherent rage - The Guardian
Posted in Government Oppression
Comments Off on Theres no solidarity in sovereign citizen protests only incoherent rage – The Guardian
Letters From the March 7/14, 2022, Issue – The Nation
Posted: at 7:47 am
Alexis Grenells January 24/31 column Goysplaining provoked a heated response from Nation readers. A selection follows.1
Thank you, Alexis Grenell, for your passionate article Goysplaining. For too long, Jews have had to weigh their commitment to progressive causes and groups against the strong possibility that their Jewish faith and ethnic identity would be attacked. Call it what it is: anti-Semitism. With the news of the terrorist attack against the little synagogue in Colleyville, Tex., perhaps it is high time for progressive groups to listen to what Ms. Grenell is saying.Rabbi Gerry Waltercincinnati2
I was all set to dissect the anti-BDS tirade by Alexis Grenell in your January 24/31 issue. But today Im too shaken and broken-hearted from seeing the rubble of the Salhiya family home in Sheikh Jarrah, which was demolished by Israeli forces yesterday morning at 3 am. Instead, I will share three observations. First, Grenell deploys considerable energy pathologizing supporters of Palestinian rights and proscribing our advocacy efforts. Surely if she is gifted a platform to trash tactics aimed at securing justice for Palestinians, she could spare a moment to let us know what form of persuasion she finds acceptable. Only the Boycott, Divestment, and Sanctions movement has caught Israels attention; but perhaps thats the point. Second, Grenell is curiously silent on the de facto BDS of Palestinians. It seems safe to conclude that denying visas to Palestinian athletes, academics, and artists, criminalising Palestinian human rights organisations, and raiding Palestinian universities are A-OK with her. Finally, I dont know of another instance in modern history in which the motives of advocates for justice were examined so forensically, nor the character of those advocates smeared with such unremitting ferocity, as supporters of the Palestinian cause.3
Instead of maligning pro-Palestine leftists, perhaps Grenell might ask herself why she is incapable of seeing Palestinians as fully human, and not merely a projection of her own racist anxiety.4
Juliana Farhalondon5
As soon as I read the first sentence of this apologia for mainstream Zionism, I recognized a familiar and egregious fallacy in Grenells thinking: her wholesale reduction of Jews to a monolith. It was clear where this was going when she began right out of the gate by rekindling the feminist controversy over the Womens March from three years ago and the accusations of anti-Semitism against its leaders, in particular Linda Sarsour, a Palestinian, and the African American feminist Tamika Mallory. Grenell writes as if the charges of anti-Semitism were unanimously embraced by Jewish feminists, or even as if all Jews agree on what counts as anti-Semitism. But I and many of my Jewish feminist counterparts publicly disagreed at the time. One could argue that this kind of homogenization is itself an age-old form of anti-Semitism.6
In late December of 2018 I posted a long defense of Linda and Tamika and an appeal to Jewish women to support their leadership of the march. I was far from alone; some 13,000 people read and responded favorably to this post, and large national organizations representing thousands of Jewish womensuch as Jewish Voice for Peace (JVP, my organization), Jews for Racial and Economic Justice (JFREJ), and even the more mainstream National Council of Jewish Womencontinued to support the Womens March and its women of color leaders. Grenell parenthetically acknowledges that many American Jews reject the equation of criticism of Israel with anti-Semitism and do support BDS, but the main direction of her piece is to convey the opposite: that anti-Zionists dont know our own history and that condemning Israel as an apartheid and settler colonial state is anti-Semitic.7 Current Issue
Subscribe today and Save up to $129.
Grenells rant against the critique of Representative Jamaal Bowman by the Democratic Socialists of America follows the same pattern of erasing dissentingand particularly anti-ZionistJewish and feminist voices. Many of us may deplore Bowmans failure to fully support Palestinian justice and BDS but think its crucial for other reasons to keep him in office. Those Jews who have continued to support Representative Bowman include JVP Action, JFREJ, and many members of DSA who also happen to be Jewish. Grenells denunciation of the left for ignoring the experience or perspective of Jews also strikes a double whammy of stereotypical reductivism. Who are the left? DSA hardly encompasses the entire spectrum of left organizations in the US, and its members are by no means unified. And whose Jewish experience is she talking about? Not mine, not that of so many of my friends and colleagues in JVP, young and old. Grenell parenthetically acknowledges that many American Jews reject the equation of criticism of Israel with anti-Semitism and do support BDS, but the main direction of her piece is to convey the opposite: that anti-Zionists dont know our own history and that condemning Israel as an apartheid and settler colonial state is anti-Semitic.8
I suggest that if Grenell wants to stop trying to speak for all Jews and to practice what she preaches, she might educate herself about anti-Zionism and its long, vibrant history among Jews in Europe, the US, and even Israel. She could start by reading the review of the new Amnesty International report in The Nation [Amnestys Echo, by Omar Barghouti and Stefanie Fox].9
Rosalind Petcheskynew york cityThe writer is a member of the Leaders Group of JVP-NYC; Distinguished Professor Emerita of Political Science, Hunter College and the Graduate Center, City University of New York; and the co-editor, with Esther Farmer and Sarah Sills, of A Land With a People: Palestinians and Jews Confront Zionism (Monthly Review, 2021).10
Grenell is correct that there are currents in DSA who weaponized support for BDS to attack Bowman and by implication DSAs electoral strategy as well as J Streets. However, DSAs National Political Committee, reflecting the majority of the membership, rejected that sectarian posture. Conflict within a big-tent organization is inevitable and messy.Paul Garver11
Readers like you make our independent journalism possible.
BDS calls for a boycott of the Israeli apartheid state, not Jews, and the international movement led by Omar Barghouti makes it clear that it condemns anti-Semitism. More and more young Jews are supporting BDS and equal rights for all. Kudos to DSA for holding its member Bowman to account for his votes that bear on this issue.David Schwartzman12
I would like to commend Dave Zirin for taking time from his sportswriting to respond to Grenells terribly wrong-headed diatribe against the pro-Palestinian left [How the Democratic Party Alienates Young Jews: A Reply to Alexis Grenell, online only, Jan. 27]. In fact, Grenells piece was not only an attack on the pro-Palestinian left, it was also an attack on Palestinians themselves and their history, of which Grenell seems unable to go beyond mainstream media tropes. Her article is replete with innuendos and falsehoods that come right out of the AIPAC playbook.13
Take, for example, her suggestion that the overwhelming opposition to BDS among American Jewry is partly the result of a public and oft-stated goal of many of Israels neighboring countries to annihilate the Jewish state. The latter is a claim straight from the Zionist and right-wing canon, using the most bombastic of terms (annihilate). But which countries is she referring to? Is the threat to annihilate coming from Lebanon? From Syria? From Jordan? From Egypt? All of these countries have been ruled for at least half a century by dysfunctional, unpopular governments or military dictatorships, which actually fear or bow to Israels military might and the US behind it, and are perennially more concerned about their own internal problems than about Israel.14
By Grenells reckoning, a two-state solution is Zionisms compromise offer, because it will parcel out small pieces to the Palestinians inside the Zionist claim of a historical homeland. The implication is that Palestinians should be grateful and thank their oppressors for being offered walled-off portions of landi.e., two or three Bantustan enclaves, which are then called a stateinstead of being thrown out completely. How generous!15
Assaf Kfourybrookline, mass.16
Grenell states in her piece that DSAs anti-Israel position is often thoughtless, self-righteous, and anti-Semitic, presumably because of its support for BDS. BDS is a call for political help to the world at large that comes from the Palestinian people themselves. To deny the validity of BDS is to effectively deny that colonized peoples are capable of any understanding of their own political situation. It denies the very political agency of Palestinians and arrogantly presumes to speak for them, as Washington and Tel Aviv (and before them, London) have done since the beginning of the military colonial project of the Nakba.Timothy Wongbrisbane, australia17
Do most American Jews really cringe like frightened mice when hearing the word boycott, thereby drinking the Anti-Defamation Leagues Kool-Aid? The first thing that comes to mind, as a son of Jewish Holocaust survivors, is the Jewish boycott of Nazi Germany. That was the boycott that triggered the retaliatory Nazi boycott of German Jewish businesses. The Jewish boycott was broken with the help of the senior Zionist leadership of the Yishuv, which formulated the infamous Transfer Agreement, propping up an economically vulnerable Nazi regime.18
Ms. Grenell seems unaware of a recent poll taken by the Jewish Electorate Institute that showed that 25 percent of American Jews believe Israel to be an apartheid state. The membership of my own organization, Social Democrats USA, has tripled since 2017, when we endorsed BDSnot as anti-Zionists but as Democratic Zionists, opposed to the apartheid of State Zionism and supportive of a genuine two-state option. Even Bernie Sanders can stand to learn something new.19
Sheldon RanzDirector of Special Projects,Social Democrats USAbrooklyn, n.y.20
In complaining that Jews should be leading the conversation about Israel and BDS on the left, Grenell falls into precisely the trap that the Israeli government has set for us all: mistakenly equating the nation of Israel with Jews worldwide, assuming that all Jews support Israel and oppose BDS, and thus branding opposition to Israeli policy as anti-Semitic. She glosses over the legitimacy and efficacy of the BDS movement, damning it with faint praise as a standard political campaign against a state entity, much as she understates the genetic cleansing and apartheid in Israel as simply the oppression of the Palestinian people. Instead, she notes that a lot of Jewish people oppose BDSmaybe, she says, because of the Nazi Holocaust, or maybe because Israel is threatened militarily, or maybe because the nation of Israel is often used interchangeably to mean the Jewish people. When she says the Jewish people, she apparently means only Jews who identify with Israel.21
No progressive would say that the Holocaust justifies oppression such as bombing the worlds largest outdoor prison (Gaza) or the eviction of Palestinians from homes their families have lived in for generations, even if it helps explain the desire for a Jewish homeland. And the military situation is a reason for, not against, taking action against Israel, which receives more military aid from the United States than any other country ($3.8 billion annually) and whose government, under Bennett as well as under Netanyahu, continues to seize Palestinian land, to maintain an apartheid wall, and to authorize Jewish-only settlements in violation of international law, making it clear that they prefer war over a two-state solution or any other peace agreement.22
So were left with Jews in this country taking criticism of Israel as an attack on the Jewish people, which is precisely the fallacious conflation of the two that Grenell bases all this on. In fact, the term Am Yisrael means the Jewish people, not the nation of Israel as Grenell says it does. The nation of Israel did not exist when that term became part of Jewish liturgy; the Hebrew word for nation is goy. This misdefinition of the Jewish people not only ignores the Jews in leadership positions in progressive organizations such as DSA that Grenell focuses on, but also overlooks the rapid growthespecially among young peopleof progressive Jewish organizations that support BDS, such as Jewish Voice for Peace (of which I am a member) and IfNotNow. These groups and individuals are not excluded from the conversation about Israel and BDS, as the article suggests; theyre just excluded from the article.23
Grenell seems to endorse a two-state solution as a compromise position that reflects a historical reality dating back thousands of years, but not only does that treat racial discrimination as a compromise, it also ignores its impracticalityindeed, impossibilityin light of Israels rejection of the idea of any Palestinian state. No one can seriously deny the virulent anti-Semitism in this country (Charlottesville, Tree of Life), in Europe, or in the Arab world. Nor can we deny that anti-Semitism often leads to attacks on Israel (though anti-Semites like Richard Spenser express their great admiration for the nation-state of Israel precisely because of its racist policies). But that does not mean that a peaceful BDS tactic aimed at illegal and inhumane government policies is anti-Semitic.24
Clyde Lelandberkeley, calif.25
This is a horrifying piece. While I disagree with DSAs stance on Bowman, Ms. Grenells stance is equally abhorrent. Israel occupies Palestineillegally, immorally, and, from a personal point of view, in a manner that fundamentally contradicts what I, a Jew, a member of J Street and Americans for Peace Now and raised in a temple, consider to be Jewish values. While one may disagree with actions of the so-called left, the real problem is that of Israels occupation, which has no more moral standing than does Chinas of Tibet or Russias of Ukraine.Marilyn Katz26
Get unlimited access: $9.50 for six months.
In arguing that American Jews should be leading conversations about BDS, Grenell accepts as given the dual-loyalty trope. American Jews are not a direct party to what is happening in Israel-Palestine, and to suggest that we defer to the opinions of American Jews on this issue acts as if American Jews were synonymous with Israel. BDS is about justice for Palestinians, and the campaign targets Israel. It is wholly inappropriate to invoke identity politics on behalf of American Jews to argue that our opinion be given special weight on this matter. When America debates our policy regarding Russia and Ukraine, no one suggests we give special credence to Americans of Ukrainian ancestry. The very idea of appealing to Ukrainian Americans to lead this conversation would be absurd.27
It is also mistaken to position Israels oppression of Palestinians as an issue about emotional harm to American Jews. Support for Palestinians should be argued on the merits, not about whether it hurts the feelings of American Jews. American Jews may get upset when Israels apartheid regime is condemned in leftist political circles, but that is not a reason not to do so. Ongoing efforts to curtail Palestinian solidarity on the left because of how it makes American Zionist Jews feel is a transparent and cynical effort to avoid the substance of this debate. Weaponizing anti-Semitism in this way (e.g., citing the Tree of Life shooting in a column about Israel-Palestine) is an attempt to shift the terms of the debate, and should be rejected.28
Andy Rattobrooklyn, n.y.29
Do most American Jews really cringe like frightened mice when hearing the word boycott, thereby drinking the Anti-Defamation Leagues Kool-Aid? The first thing that comes to mind, as a son of Jewish Holocaust survivors, is the Jewish boycott of Nazi Germany. That was the boycott that triggered the retaliatory Nazi boycott of German Jewish businesses. The Jewish boycott was broken with the help of the senior Zionist leadership of the Yishuv, which formulated the infamous Transfer Agreement, propping up an economically vulnerable Nazi regime.30
Ms. Grenell seems unaware of a recent poll taken by the Jewish Electorate Institute that showed that 25 percent of American Jews believe Israel to be an apartheid state. The membership of my own organization, Social Democrats USA, has tripled since 2017, when we endorsed BDSnot as anti-Zionists but as Democratic Zionists, opposed to the apartheid of State Zionism and supportive of a genuine two-state option.31
Sheldon RanzDirector of Special Projects,Social Democrats USAbrooklyn, n.y.32
Grenells article needs some respectful pushback. There are many prominent Jews such as Amy Goodman of Democracy Now! and Medea Benjamin of Code Pink who are very critical of Israels policies, practices, and treatment of Palestinians. Those who havent given up on the two-state solution keep pushing America and Israel to get it done. While it may seem like insensitivity toward Israel, its rather impatience and frustration with the Israeli and American governments recalcitrance toward getting it done.33
Jews have been traumatized. This is a fact. Palestinians are being traumatized. This is also a fact. All people need to push to integrate past traumas and end current traumas. This can be done, and the two-state solution is the way to do this.34
Ed Ferreiranew sharon, me.35
Grenells commentary resonated with me. As a human rights and social justice researcher and advocate, I frequently find that the human rights realities, concerns, and lived experiences of discrimination and persecution faced by Jewish people both currently and historically are neglected, downplayed, and denied by many individuals and institutions who self-identify with the left.36
There is no sound moral basis for this lack of solidarity with and abandonment of Jewish people, their human rights, welfare, freedom, and access to justice and equality. It is made all the more painful and harmful at this particularly precarious and dangerous time for so many minorities, including Jews, as anti-Jewish bigotry and violence continue to rise in the United States, Canada, and globally. An urgent course correction by the left and a concurrent effort to reflect upon and address the ideological origins of left-wing anti-Jewish prejudice and hostility are needed. The harm they have caused and continue to cause must be repaired.37
Noam SchimmelLecturer, International and Area Studies,University of California, Berkeley38
Grenell says absolutely nothing about the illegal settlements or the disproportionate response against the Palestinians whenever there is a flare-up of violence. What exactly does she want the Palestinians to do when their land is being taken and they have few recourses? BDS is nonviolent protest, yet even that she opposes. She has the audacity to say that the left alienates Jews. Well, as a very left-leaning Jew, I can say that its not the left that alienates me, but people like her that think that all Jews must accept what Israel is doing because they are fellow Jews.Miriam Applebaum39
There is a term to describe Alexis Grenell: PEP, or progressive except for Palestine. She states that DSA and the left in general are making a mistake by offending Jews. If offending Jews means recognizing the forced expulsion of 750,000 Palestinians in 1948; the massacre of children, women, and men in Deir Yassin the same year; some 60 Israeli laws diminishing the rights of Palestinians; group punishment in which the family of a person arrested for an act annoying the Israel Defense Forces has their home demolished; extrajudicial executions, torture, knee-capping, and murder of peaceful demonstrators; and the destruction of hundreds of villages, these offended persons need more awareness.40
Today, boycotting is the only peaceful way to protest the mistreatment of Palestinians. But in a paragraph critical of BDS, Grenell compares the campaign to the Nazi boycott of Jews before confiscating their assets. I see another troubling parallel policy of Israels with that of Nazi Germany: Hitler wanted an Aryan nation, and Israels leaders want only Jews.41
According to Grenells column, Linda Sarsour stated that one cannot be a feminist and support Israel. I would find it difficult to work with a person who supported improving human rights for all women except Palestinian women under Israeli occupation. One cannot work against oppression without identifying the oppressor.42
Herschel Solesportland, ore.43
See the rest here:
Posted in Government Oppression
Comments Off on Letters From the March 7/14, 2022, Issue – The Nation
Didnt Become a Hostage- Former World Chess Champion Calls Magnus Carlsen the Bridge Between Traditional and Modern Chess – EssentiallySports
Posted: at 7:46 am
The computers and super engines have brought a vast difference between the modern chess and the chess that was played before the end of the 20th century. Though the game is still fascinating and mysterious as always, the way modern players approach chess today has completely changed.
ADVERTISEMENT
Article continues below this ad
Anyone who dominates a sport for more than a decade defines its course and in chess that responsibility automatically belongs to the world chess champion Magnus Carlsen. The former world chess champion Garry Kasparov believes he is the best of traditional and modern chess combined in one mind.
ADVERTISEMENT
Article continues below this ad
The Russian Grand Master said, Todays chess is in many ways Magnus chess. Magnus is clearly superior to all the rest of his generation of chess players.
Obviously, with modern technology, you can analyze chess games better than before, but you cant take help from the computer while playing an actual game. The way Magnus approaches his games is incredible to watch. As I remember while working with him, he was always able to disengage from the computer. In fact, he did not become a hostage to what he saw on the screen said Kasparov.
He further added, The machine helps to develop solution, but he always found the most interesting, pragmatic solutions specifically for modern chess.
Maybe this is the reason the Norwegian Grand Master is still at the top for over a decade, even though the game is constantly changing.
ADVERTISEMENT
Article continues below this ad
Well, the simple answer would be that he has an extremely gifted mind, but thats just half of it. The reason he has dominated the game in such evolutionary times is that he has the perfect balance of technology and his ability to analyze the best moves. Its not just the classical chess that he has dominated. He is quite skilled at fast online chess as well.
Super engines can only give you information and million different moves, but as a player, its completely up to you how you maneuver your pieces on the board to outsmart your opponent, and apparently, Magnus knows it all.
ADVERTISEMENT
Article continues below this ad
Is Magnus Carlsen the best chess player of all time?
WATCH THIS STORY-Usain Bolt eating 1000 Chicken Nuggets in China Explained as Athletes Suffer at Beijing Winter Olympics 2022
See the original post:
Posted in Chess Engines
Comments Off on Didnt Become a Hostage- Former World Chess Champion Calls Magnus Carlsen the Bridge Between Traditional and Modern Chess – EssentiallySports
Can the academy rein in Big Tech? – Times Higher Education
Posted: at 7:46 am
Time to think
Has Big Tech lived up to its purportedly altruistic ideals? Googles unofficial motto of dont be evil suggests that its intention was always benevolent, despite the deceptive and unethical practices it has adopted in a number of areas not least facial recognition software, which reportedly exploited homeless people of colour.
Bill Gates now heads one of the worlds largest private charities, yet the company he founded, Microsoft, is relatively open about its compliance with state censorship in China. Apple contributes millions of dollars in financial aid for disaster relief but has a grim track record when it comes to working conditions, including allegationsthat it has potentially directly or indirectly benefited from forced Uyghur labour. Amazons working practices have also come under serious scrutiny, especially in the wake of the pandemic and the recent destruction of one of its giant US warehouses by a tornado. As for Facebook (now Meta), there is blood on its hands after it failed to prevent its platform being used to incite violence against the Rohingya minority in Myanmar.
But computing was never about the greater good, no matter what those Big Five firms claim. It was, and still is, about the greater exploitation of productivity. From the moment humans sharpened a flint, technology has been a way to make tasks more effective and, nowadays, thats done for profit. Before we had digital computers, we had human ones: people usually women, as it was seen as a low-status role employed to calculate and repeat those calculations by hand. The goal is to maximise production, to capitalise, to hold market power.
THE Campus views: What can universities learn from Amazon?
It doesnt stop there, though. Big Tech reaches much further than might ever have been expected in the industrys early days. The rise of machine learning and the access to the vast quantities of user-centred data that spurs it on means that Silicon Valley corporations have a profound grip on our lives. They hold vast power and if we want to enjoy the conveniences of a digital society then we cant entirely avoid that. Its a trade-off. Our society thrives on interconnections and limitless access to information; at times, it needs it. Imagine this pandemic without that online space. Imagine getting through a day without your smartphone.
At present, the major developments in AI come from those with the money, the talent and the data. The worlds most powerful nations, the US and China, are also the AI superpowers. Start-ups making new leaps are acquired by established corporations. University researchers are poached into business, lured by high wages and (potentially) better working environments. The resources of grant-funded projects are microscopic when comparedwith the big players budgets. Can universities really have much influence on where the AI revolution takes us?
They can but the roles have changed. Universities are now working on a different scale, but we can still innovate, still foster ideas, still advocate for altruistic and beneficial technology. We can explore data and push for open science. We can work with industry to co-create and advise. And we can hold a mirror up to Big Tech firms and force them to look at themselves.
In the past few years, there has been a marked increase in the academic study of AI ethics. Although it was already an important subject in its own right, the escalation of algorithmic decision-making (and the fallout when those decisions go wrong) pushed ethics into the spotlight. The UK House of Lords Select Committee on Artificial Intelligence published its report in late 2018. It was well received by the community and acknowledged that ethical development was key, stating: The UKs strengths in law, research, financial services and civic institutions mean it is well placed to help shape the ethical development of artificial intelligence and to do so on the global stage.
Big Tech is STEM-focused and it often treats other fields as unimportant, dismissing centuries of philosophy, arts, humanities and social science as irrelevant. But it is learning that it needs to engage. An increased emphasis on the responsible development of technology means it has listened to experts outside its walls. Some of this is regulatory pressure, much comes from academia, but there is also a heartening increase in public awareness, engagement and activism. It didnt stop Google from firing its ethics researchers Timnit Gebru and Margaret Mitchell for self-critical research, but it did force it to re-evaluate its practices following the backlash.
But universities shouldnt be too smug. We need to get our own house in order too. When working with industry, look for strings. Plenty of institutions receive money from tech companies and its not unheard of for funding to cloud judgement something the Massachusetts Institute of Technology learned the hard way when it accepted donations from Jeffrey Epstein even after his conviction as a sex offender.
The slow and contemplative academic practices, often mocked by the fast-moving tech world, offer space to reflect on how new technologies are developed, deployed and used. We are an antidote to the goal-focused business world.
That said, we cannot be too slow. We are also perpetrators and victims of our own productivity practices. If we wait anything from a few months to a few years for a journal article to be published, weve missed the boat. We have to rethink our own ways of responding and interacting. When it comes to Big Tech, we can contribute in new ways, but we cant afford to be left behind.
Kate Devlin is reader in artificial intelligence and society at Kings College London.
How does it all end for humanity? Will it be a giant meteorite crashing from the sky, like it was for the dinosaurs? Or a catastrophic thermonuclear explosion, as we all thought it would be during the Cold War? Or a global pandemic many times deadlier than Covid-19?
Australian philosopher Toby Ord argues in his 2020 book The Precipice: Existential Risk and the Future of Humanity that, in fact, the greatest threat is posed by an artificial super-intelligence poorly aligned with human values. Indeed, he bravely (if that is the word) estimates that there is a 10 per cent chance of such an end in the next century.
As someone who has devoted his whole professional life to building artificial intelligence, you might think such concerns would give me pause for thought. But they do not. I go to sleep at night and try to dream instead of all the promise that science in general and AI in particular offer.
It may be decades, or even centuries, before we can build an AI to match human intelligence. But once we can, it would be very conceited to think a machine could not quickly exceed it. After all, machines have many natural advantages over humans. Computers can work at electronic speeds, which far exceed biological ones. They can have much greater memory, ingesting datasets larger than human eyes can contemplate and never forgetting a single figure. Indeed, in narrow domains such as playing chess, reading X-rays, or translating Mandarin into English, computers are already superhuman.
But the fact that more general artificial super-intelligence remains a distant prospect is not the reason that I am unconcerned by its existential implications. Im unconcerned because we already have a machine with far greater intelligence, power and resources at its disposal than any one individual. Its called a company.
No person on their own can design and build a modern microprocessor. But Intel can. No person on their own can design and build a nuclear power station. But General Electric can. Such collective super-intelligence is likely to surpass the capacities of mechanised super-intelligence for a long time to come.
That still leaves the problem of value alignment, of course. Indeed, this seems to be the main problem we face with todays companies. Their parts the employees, the board, the shareholders may be ethical and responsible, but the behaviours that emerge out of their combined efforts may not be. Just 100 companies are responsible for the majority of greenhouse gas emissions, for instance. And I could write a whole book about recent failures of technology companies to be good corporate citizens. In fact, I just have.
Consider, for example, Facebooks newsfeed algorithm. At the software level, its an example of an algorithm misaligned with public good. Facebook is simply trying to optimise user engagements. Of course, user engagement is hard to measure, so Facebook decided instead to maximise clicks. This has caused many problems. Filter bubbles. Fake news. Clickbait. Political extremism. Even genocide.
This flags up a value alignment problem at the corporate level. How could it be that Facebook decided that clicks were the overall goal? In September 2020, Tim Kendall, who was director of monetisation for Facebook from 2006 through 2010, told a Congressional committee that the company sought to mine as much attention as humanly possible...We took a page from Big Tobaccos playbook, working to make our offering addictive at the outsetWe initially used engagement as sort of a proxy for user benefit. But we also started to realise that engagement could also mean [users] were sufficiently sucked in that they couldnt work in their own best long-term interest to get off the platform...We started to see real-life consequences, but they werent given much weight. Engagement always won, it always trumped.
It is easy to forget that corporations are entirely human-made institutions that only emerged during the industrial revolution. They provide the scale and coordination to build new technologies. Limited liability lets their officers take risks with new products and markets without incurring personal debt often funded, in the modern era, by plentiful sources of venture capital, alongside traditional bond and equity markets.
Most public listed companies came into being only very recently, and many will soon be overtaken by technological change; it is predicted that three-quarters of the companies on the Standard & Poors 500 index today will disappear in the next decade. About 20 years ago, only four of the 10 most valuable publicly listed companies in the world were technology companies: the industrial heavyweight General Electric was top, followed by Cisco Systems, Exxon Mobil, Pfizer and then Microsoft. Today, eight out of the top10 are digital technology companies, led by Apple, Microsoft and Alphabet, Googles parent company.
Perhaps it is time to think, then, about how we reinvent the corporation to suit better the ongoing digital revolution. How can we ensure that corporations are better aligned to the public good? And how do we more equitably share the spoils of innovation?
This is the super-intelligence value-alignment problem that actually keeps me awake at night.
And this is where the academy has an important role to play. We need scholars of all kinds to help imagine and design this future. Economists to design the new markets. Lawyers to draft new regulation. Philosophers to address the many ethical challenges. Social scientists to ensure humans are at the centre of social structures. Historians to recall the lessons from past industrial change. And many others from across the sciences and humanities to ensure that super-intelligence, both in machines and corporations, creates a better world.
Toby Walsh is an ARC Laureate Fellow and Scientia professor of artificial intelligence at UNSW Sydney and CSIRO Data61. His most recent book, 2062: The World that AI Made, explores what the world may look like when machines match human intelligence. His next book, out in May, is Machines Behaving Badly: The Morality of AI.
In 1995, Terry Bynum and I wrote a feature article for Times Higher Education that asked, What will happen to human relationships and the community when most human activities are carried on in cyberspace from ones home? Whose laws will apply in cyberspace when hundreds of countries are incorporated into the global network? Will the poor be disenfranchised cut off from job opportunities, education, entertainment, medical care, shopping, voting because they cannot afford a connection to the global information network? More than a quarter of a century on, I am still asking.
By now, there exists a deep-seated global dependency on digital technology. The Canadian governments January 2021 report, Responsible Innovation in Canada and Beyond: Understanding and Improving the Social Impacts of Technology, calls for solutions that are inclusive and just, undo inequalities, share positive outcomes, and permit user agency. I agree. To that end, we need an ever-greater emphasis on what we should now call digital ethics, defined as the integration of digital technology and human values in such a way that the former advances rather than detracts from the latter.
Two recent ethical hotspots reinforce this need. One is the estimated 360+ million over-65s who are currently on the wrong side of the digital divide; as the world has come to rely even more heavily on digital technology during the pandemic, these people have been put at greater risk. Another example is the 700+ UK sub-postmasters who were accused of theft on the basis of a faulty digital accounting system. Unverified digital forensics was the only evidence used to obtain the convictions many of which have now been overturned.
Only virtuous action can promote an ethical digital age. Rules may offer some guidance, but they are a double-edged sword. Within industry and government, a compliance culture has taken firm hold, strangling any opportunity for dialogue and analysis of the complex socio-ethical issues related to digital technology. Organisational silo mentalities must also be replaced by inclusivity and empathy.
Genuinely virtuous action can be promoted in three different ways. Top-down drivers are typically impositions by bodies of authority, which dictate where resources should be placed to achieve some overall goal. Middle-out drivers involve empowering all those within an organisation to propose new ideas, initiate change and support it. Bottom-up drivers emanate typically from grassroots collective action, often citizen-led.
Whistleblowing is a bottom-up driver and has been successfully used to expose and sometimes rectify unethical activity, primarily related to personal data. In 2013, Edward Snowden leaked highly classified information from the US National Security Agency, revealing its numerous global surveillance programmes, conducted with the cooperation of telecommunication companies and European governments. In 2018, Christopher Wylie revealed that Cambridge Analytica, a political consultancy that worked for the Trump campaign, had illegally obtained Facebook information about 87 million people and used it to build psychological profiles of voters and then spread narratives on social media to ignite a culture war, suppress black voter turnout and exacerbate racist views. In 2021, Frances Haugen disclosed thousands of Facebooks internal documents to the Securities and Exchange Commission and The Wall Street Journal. This has led to investigations into Facebooks updating of platform-driving algorithms, impacts on young people, exemptions for high-profile users and response to misinformation and disinformation.
Some ethical hotspots may be obvious while others may not, but all must be addressed. This can only be achieved through effective digital ethics education and awareness programmes that promote proactive individual social responsibility, both within work and beyond it, while taking into account both global common values and local cultural differences. Discussion, dialogue, storytelling, case study analysis, mentoring and counselling are all useful techniques.
The way forward, then, is a middle-out, interdisciplinary, lifelong-learning partnership of primary education, secondary education, further education, higher education and beyond. Universities have a key role to play. While some have introduced digital ethics into their technology degrees, others have not, and most existing courses are elective. This must change. Relevant digital ethics elements should be mandatory across undergraduate and postgraduate programmes within many disciplines, including technology and engineering, business and management, science, finance and law.
Nurturing practical wisdom and developing individuals confidence and skills to act responsibly and ethically will increase graduates awareness and commitment as they move into the world of work. However, to make a lasting difference, universities must engage politically, commercially, industrially, professionally and internationally to influence the strategies and attitudes of those beyond their own walls. They must develop and promote a new vision of the digital future that is theoretically grounded but also pragmatic if industry and government are to embrace it.
We must accept and adjust to the fact that we are all technologists to a lesser or greater degree. How we educate our future generations must reflect this change to ensure that the digital age is good for each individual, as well as for the world at large.
Simon Rogerson is professor emeritus at De Montfort University. He founded the Centre for Computing and Social Responsibility, the international ETHICOMP conference series and the Journal of Information, Communication and Ethics in Society. He was Europes first professor of computer ethics. His latest book is The Evolving Landscape of Ethical Digital Technology.
The biggest peril stemming from Big Tech is nothing less than the loss of human autonomy for the sake of increasing efficiency.
Even when decisions affecting a person are made by other human beings such as our family, government or employer we understand the power relationships between those decision-makers and ourselves, and we can choose to obey or to protest. However, if the computer says no in a systemthat we cannot escape, protest becomes meaningless, as there is no social element to it.
Furthermore, Big Tech robs us of our core competencies, which are important aspects of our intelligence and, ultimately, our culture. Take map-reading and orientation. While it may be both efficient and convenient to rely on Google Maps, habitual use means that we lose our ability to decide how to drive from A to B. More importantly, we lose the ability to navigate and understand our geographical environment, becoming ever more dependent on technology to do this for us.
Many people may not care about this particular trade-off between convenience and ability. Others may barely even notice it. But the tech-driven loss of decision-making and other abilities is pervasive. A more concerning example regarding autonomy is the profiling enabled by tracking technology when we browse the World Wide Web and engage on social media. The aggregation of data about our preferences and interests is all-encompassing; it does not merely include our shopping choices, but also our aesthetics, our religious or political beliefs, and sensitive data about health or sexual proclivities. Profiling enables the micro-targeting of what we consume and this includes news results, resulting in the widely lamented establishment of so-called filter bubbles or echo chambers.
The algorithms are serving us the content we apparently crave, or at least agree with, but they pigeonhole us into groupings that we cannot escape. Profiling deprives us of the autonomy to decide which content to access and, more broadly, the skill of media literacy. The consequences are serious, as the polarisation of opinion and the micro-targeting of advertising directly affect democracy, as was illustrated by the Facebook-Cambridge Analytica scandal.
Moreover, while the extraction of knowledge from big data has many economic, social and medical benefits, there are numerous instances where more knowledge is positively harmful. For example, imagine a free online game that allows the profiling of individuals regarding their likelihood of succumbing to early onset dementia. Learning of their risk profile may affect peoples mental health. Sharing the information with companies may lead to individuals being denied employment, credit or insurance. It would undermine the spreading of risk on which the whole health insurance industry is currently predicated.
Finally, it is not only what Big Tech does to us, but its sheer power that is disconcerting. At its core, Big Tech is based on the networks connecting us. The more people are connected to a network, the more useful it becomes, leading inevitably towards monopolies. This is true for e-commerce, online auctions, search engines and social media.
In addition, Big Tech firms size and power allows them to invest heavily in research and development, meaning they are always ahead of the innovation game. This makes it difficult for governments or publicly funded research institutions, such as universities, to keep up. In turn, it means that the research and innovation agenda is geared towards making Big Tech companies richer and even more powerful.
This loop has created a mindset that sees unbridled innovation through big data, data mining and artificial intelligence as imperative, regardless of ethics and the impact on humanity: the next, inevitable evolutionary step in human development. Universities should question this inevitability through their core missions in teaching and research. They must guard their independence from both politics and commercial interests.
In particular, universities should encourage truly interdisciplinary research, integrating all subjects as equal partners, including in terms of the funding and leadership of projects. It is wrong, for instance, that most funding from UK Research and Innovation in the area of artificial intelligence and autonomous systems has gone to fund computer science and engineering projects, offering little, if any, opportunity for ethicists, lawyers, humanities and social science researchers to critically reflect on what is good for human progress as a whole.
Universities should lead the dialogue about Big Tech and enable cross-fertilisation between disciplines and mindsets. After all, how you define the challenges created by Big Tech depends on your perception of them. Accordingly, teaching in computer science and engineering should also contain elements of ethics, law (such as data protection law), social sciences and humanities.
Of course, however public resources are divided up, they will always be dwarfed by those available to the Big Tech companies. For that reason, some people perceive the power relationship between university research/teaching and Big Tech innovation as akin to that between a person with a peashooter and Godzilla. But sometimes the question of who comes out on top is not only determined by power conferred by technology and money. It is also important to consider who can influence the mindset of human beings and this is precisely where universities have a big stake in the game.
Julia Hrnle is professor of internet law at the Centre for Commercial Law Studies, Queen Mary University of London.
Read the original post:
Posted in Chess Engines
Comments Off on Can the academy rein in Big Tech? – Times Higher Education
FIDE World Women’s Team Championship Final: Russia Wins Gold In Victory Over India – Chess.com
Posted: at 7:46 am
Russia has defeated India 2.5-1.5 and 3-1 to confidently triumph in both rounds of the finals of the World Women's Team Championship that concluded in Sitges, Spain. If the semi-rapid event can be considered for historical continuity, this victory is the second for Russia in the championship after its earlier win in 2017.
For the first time in the event, India wins a medal, a silvera creditable reward for the team's fine run in the tournament until the finals. India had lost just one match in the entire tournament until the finals, again to Russia in their Pool A encounter in the fourth round of the league stage.
Early difficulties on boards with the black pieces cost India dearly in both rounds, as they burdened players on other boards with pressure to score, and the team could not recover. GM Kateryna Lagno came up with a stellar performance for Russia winning her games in both rounds, exhibiting reliability much needed in a team event. GM Dronavalli Harika with the black pieces defeated GM Aleksandra Goryachkina on the top board in the first round, which was the only bright spot for India in the finals.
Live coverage of round one. Watch all of the live coverage at youtube.com/chess.
Russia started the finals as the favorite, with three grandmasters among its ranks and superior Elo rankings on all the boards. However, as in most sports, the sum of individual strengths of a team's players doesn't always equal its total, and India could be optimistic because its players had shown fighting spirit and resourcefulness until reaching the finals.
Just as the games moved into the early middlegame, the first round of the finals started looking evenly poised for both teams. Russia had an advantage on the third board through Lagno who seemed to have developed a good initiative right out of the opening against IM Bhakti Kulkarni, from a fashionable variation of the Caro Kann Defense. On the fourth board, WGM Mary Ann Gomes seemed to have developed a good positional edge against IM Alina Kashlinskaya from a slow Reti Opening.
The other two games looked evenly poised. On the top board, Goryachkina was surprised with a pawn sacrifice variation by GM Dronavalli Harika. WGM Vaishali vs. GM Alexandra Kosteniuk seemed to be on a level footing. So, there were boards to be both happy as well as worrisome for both the teams!
When there were no computers to teach chess opening theory, some openings had been branded as "unsound" by chess experts, mainly due to the pawn structures arising out of early middlegames. The variation of the Caro-Kann Defense employed by Kulkarni against Lagno4...Nf6 5.Nxf6 exf6had been condemned as "bad" even as late as the 1980s. But the variation has been spruced up and presented as playable in the past few years, thanks in no small measure to deep preparation with chess engines, though still looked at with a tinge of skepticism. But it wasn't a real surprise that Kulkarni adopted it for this game, as many top Indian players have employed it.
Also, in team championships, when stronger teams (in terms of Elo or otherwise) wish to outwit the opposition without taking much risk, the tendency is to "keep control" and keep it simple: play solid, sound openings with both colors and adhere to the principle, "Win with white pieces and draw with black pieces." Working the logic from the reverse, lower-rated opponents tend to play sharper openingseven if they aren't entirely soundto provoke "stronger" players into playing more tactical and sharper to create chances.
Kulkarni tried to play actively with black pieces, but her opening play backfired fast. As the game progressed, it was obvious that Lagno had developed a serious advantage: Black's pawn advances on the kingside looked premature:
This game quickly unraveling to be difficult for India, Gomes seemed the best bet for an equalizing win, to build up her early middlegame advantage, and to push for a victory against Kashlinskaya:
By this time, Vaishali's game looked to be inching towards a draw, as the ending didn't seem to possess any particular danger for White. But she blundered with a tactical oversight:
Curiously, in the league stage, Vaishali had also blundered in an ending with rooks and a minor piece and lost to Kosteniuk.
With Kosteniuk's game being the first to finish, Russia's victory seemed inevitable, as Lagno held a huge advantage against Kulkarni. But Harika's fighting spirit brought a creditable victory over Goryachkina.
Harika is the mainstay of this Indian women's team, being the only grandmaster and Elo topper. Fresh from her excellent showing in the Online Olympiad just a couple of weeks ago, she has been the main anchor of the Indian team in the absence of GM Koneru Humpy. Her game against Goryachkina seemed to be an even contest, as Harika employed a sharp opening variation:
One can only speculate that fatigue was the reason for Goryachkina's collapse in the game with the format forcing the players to play more than a dozen games in just six days.
With India desperately needing to win the second round to force a tiebreak, things didn't start well for them. Opening choices with black pieces seemed to be a recurring issue for the team, as IM Polina Shuvalova on the fourth board quickly exposed difficulties in Gomes' Kan variation of the Sicilian Defense. Once again, just as with Kulkarni in the first round, the difficult position that Gomes faced early in the round resulted in pressure on her other teammates:
Even before Shuvalova's win was achieved, Kosteniuk-Vaishali had ended in a relatively quick draw. On the top board, in a reversal of fortunes, Harika survived anxious moments throughout the game:
With the gold medal for the team almost in sight, Lagno played steadily in the long and final game of the event and even punished IM Tania Sachdev for pushing too hard in a quest to win for the sake of the team:
All games - Finals
The 2021 FIDE World Women's Team Championship was a 12-team event featuring teams representing chess nations around the world. The event ran from September 27 to October 2 and was broadcast on Chess.com.
Related:
Read more:
FIDE World Women's Team Championship Final: Russia Wins Gold In Victory Over India - Chess.com
Posted in Chess Engines
Comments Off on FIDE World Women’s Team Championship Final: Russia Wins Gold In Victory Over India – Chess.com
Air Pollution May Trigger Psoriasis Flares – AJMC.com Managed Markets Network
Posted: at 7:46 am
A JAMA Dermatology study found that greater exposure to air pollutants, such as carbon monoxide and fine particulate matter, were significantly associated with later psoriasis flares.
Higher exposure to air pollutants may increase the risk of flare and more severe disease in patients with psoriasis, according to study findings published today in JAMA Dermatology.
Characterized by a relapsing-remitting course, psoriasis flares have been noted to be triggered by environmental factors, including infections, stressful life events, and drugs. Moreover, worsening of other diseases that share common inflammatory pathways to psoriasis, such as atopic dermatitis, have been associated with exposure to air pollution.
After inhalation, pollutants can circulate in the bloodstream, exerting oxidative damage and causing inflammationair pollutants can directly come into contact with the skin, said the study authors. Whether air pollution could trigger psoriasis flares is not known.
Seeking to investigate whether short-term exposure to environmental air pollution is associated with psoriasis flares, they conducted an observational study, comprised both case-crossover and cross-sectional analyses. They retrospectively analyzed longitudinal data from September 2013 to January 2020 on patients with chronic plaque psoriasis consecutively attending the outpatient dermatologic clinic of the University Hospital of Verona.
Mean and cumulative (area under the curve [AUC]) concentrations of several air pollutants were compared in the 60 days preceding the psoriasis flare and control visits, including for carbon monoxide, nitrogen dioxide, other nitrogen oxides, benzene, coarse particulate matter (PM; 2.5-10.0 mcm in diameter, PM10) and fine PM (< 2.5 mcm in diameter, PM2.5).
Patients recruited for the case-crossover analysis had at least 1 disease flare, defined as Psoriasis Area and Severity Index (PASI) increase of 5 or greater between 2 consecutive assessments in a time frame of 3 to 4 months, whereas patients selected for the cross-sectional analysis included those who received any systemic treatment for 6 or more months, with grade 2 or higher consecutive PASI assessment.
Overall, the study included data on 957 patients with plaque psoriasis with 4398 follow-up visits (mean [SD] age, 61 [15] years; 62.9% male) and more than 15,000 measurements of air pollutant concentrations from the official, open-source bulletin of the Italian Institute for Environmental Protection and Research.
A total of 369 (38.6%) patients with psoriasis flare were included in the case-crossover study and 4072 follow-up visits from 957 patients were used for the cross-sectional analysis.
In findings of the case-crossover study, concentrations of all pollutants (as mean and AUC) were shown to be significantly higher in the 60 days before psoriasis flare (median [interquartile range] PASI, 12 [9-18]), compared with the control visit (median PASI, 1 [1-3); P < .001).
Further sensitivity analyses applying different definitions of psoriasis flare, such as 50% and 100% increases in PASI, indicated that 515 (35.8%) patients had at least a 50% increase and 452 (47.2%) had at least a 100% increase in PASI compared with the control visit, respectively.
Regarding the cross-sectional analysis, exposure to mean PM10 over 20 mcg/m3 and mean PM2.5 over 15 mcg/m3 in the 60 days before assessment were associated with a higher risk of PASI 5 or more points worsening (adjusted OR [aOR], 1.55; 95% CI, 1.21-1.99; aOR, 1.25; 95% CI, 1.0-1.57, respectively). Sensitivity analyses that stratified for trimester of evaluation, with various lag of exposure and adjusting for type of treatment, were found to yield similar results.
Further study is needed to examine whether these findings generalize to other populations and to better understand the mechanisms by which air pollution may affect psoriasis disease activity, the concluded researchers.
Reference
Bellinato F, Adami G, Vaienti S, et al. Association between short-term exposure to environmental air pollution and psoriasis flare. JAMA Dermatol. Published online February 16, 2022. doi:10.1001/jamadermatol.2021.6019
See the original post:
Air Pollution May Trigger Psoriasis Flares - AJMC.com Managed Markets Network
Posted in Psoriasis
Comments Off on Air Pollution May Trigger Psoriasis Flares – AJMC.com Managed Markets Network
Dermavant faces a perfect storm of pressures for tapinarof, but there is hope for the psoriasis drug – FiercePharma
Posted: at 7:46 am
Dermavants tapinarof launch will need to withstand some turbulence, but it still has a chance of breaking through the atmosphere.
This is according to analysts at Jefferies, who forecast stormy weather ahead for the topical psoriasis drug that is looking for a second-quarter approval and a swift launch.
There is a troika of challenges on the horizon for tapinarof. First, COVID: The pandemic is not over, as omicron has reminded us, and this will continue the pressure we have seen on all drug launches.
Jefferies notes that the COVID chaos means many launches have disappointed even from large cap biotechs and pharma, so dont be surprised if Dermavanta small biotech that's part of the Roivant cluster of biopharmasalso ends up struggling.
RELATED: Arcutis' topical cream hits goal in psoriasis phase 3, setting up FDA filing and market showdown
The psoriasis market is already a competitive and a tight one, with high efficacy biologics from several Big Pharmasincluding the $20 billion-a-year Humira from AbbVieJohnson & Johnsons Remicade and its biosimilars along with newer follow-up drugs like Skyrizi and Tremfya. That all combines to put significant pressure on any new drug entry.
Third, Jefferies says that when you look back, past topical launches have generally looked mixed. Older topical creams for the condition include Bausch Healths Duobrii and Almirall/MC2s Wynzora, with the former making just $88 million in 2020 (and the latter only nabbing approval in mid-2020 and yet to report full-year sales).
Jefferies sees tapinarof revenue this year hitting $10 million at the high end, should it launch around mid-2022, and ramping up to $50 million in 2023 for its psoriasis label.
But Dermavant is clearly focused on a strong trajectory and is currently building out a sales team, adding 75 to 100 reps and looking to strengthen market access over the next few months, the analysts said in a note to clients.
Dermavant forked over 150 million pounds sterling ($198 million) upfront in 2018 to get its hands on what was then GlaxoSmithKlines phase 3-ready psoriasis cream. Since then, Dermavant ran its own tapinarof trials, which have broadly shown efficacy, but it's hoping the big win will be on safety.
The current crop of blockbuster psoriasis and plaque psoriasis biologics all need injecting, and the systemic nature of these drugs can lead to immune system-related side effects. A topical cream should, in theory, be safer overall.
RELATED: Dermavant shows deepening effects of tapinarof on psoriasis ahead of FDA filing
But Dermavant already has topical rivals waiting in the wings. Arcutis Biotherapeutics is also anticipating an FDA decision this yearJuly 29, to be exactfor its hopeful ARQ-151, a topical formulation of the PDE4 inhibitor found in AstraZenecas chronic obstructive pulmonary disease treatment Daliresp.
There are also pills for psoriasis on the market, including Amgens Otezla, another PDE4 inhibitor that it bought from Bristol Myers Squibb in 2019.
And then there's Bristols own oral follow-up to that drug, deucravacitinib, a TYK2 drug and a member of the JAK family.
Pfizers Xeljanz, as a JAK inhibitor, is facing the same scrutinyand was all the way back in 2015 slapped with an FDA complete response letter for its oral psoriasis med, with the Big Pharma later giving up on getting it approved for that indication.
Dermavant's new sales team will have to chart a difficult course but will hope to rise to the challenge.
See the original post here:
Dermavant faces a perfect storm of pressures for tapinarof, but there is hope for the psoriasis drug - FiercePharma
Posted in Psoriasis
Comments Off on Dermavant faces a perfect storm of pressures for tapinarof, but there is hope for the psoriasis drug – FiercePharma
Metabolic syndrome and its components in psoriatic arthritis | OARRR – Dove Medical Press
Posted: at 7:46 am
Introduction
Psoriatic arthritis (PsA) is a chronic autoinflammatory condition distinguished by a variety of clinical phenotypes. It is most frequently associated with patients who have psoriasis (PsO). It is a devastating form of spondyloarthropathy that significantly affects patients life and increases cardiovascular mortality and mortality in general.1,2 Based on a rising awareness and knowledge of the immunologic mechanism, psoriatic disease is increasingly being regarded as a systemic disease, the consequences of which impact more than skin and joint health.3,4 The interest in determining the cardiovascular (CV) disease risk factors linked to PsA and PsO has intensified, with most of the early data and the underlying pathogenetic theories informed by the literature on rheumatoid arthritis (RA).5,6 Retrospective and prospective data from the large observational cohort, and evidence gleaned from various imaging techniques, show that PsO and PsA are linked to increased CV risk.4,7,8 Previous studies also indicate that CV diseases are the leading etiology for deaths in PsA patients, accounting for between 20% and 56% of those deaths.9,10 A relationship has been established in previous studies between increased risk of contracting CV disease in PsA and the existence of cardiometabolic risk factors, namely high blood pressure, adiposity, diabetes, hyperlipidemia, and chronic system inflammation.11 Moreover, the prevalence of MetS, described as an amalgamation of the risk factors mentioned above, is also higher in individuals diagnosed with PsA.
Metabolic syndrome denotes a collection of metabolic risk factors that increase the probability that CV disease will develop. Since the 1940s, there has been evidence that some metabolic abnormalities are associated with CV disease. Insulin resistance (IR), hypertension (HTN), abnormal cholesterol levels, and obesity are examples of these metabolic factors.
Metabolic syndrome is a grouping of five traditional CV risk factors. There are five distinct MetS definitions.1214 However, it has been proven that the various definitions of MetS are comparable in terms of prognosis and therapy.15 According to the most widely used current guidelines, which were revised by the National Heart, Lung, and Blood Institute (NHLBI) as well as the American Heart Association (AHA) in the United States in 2005, the diagnosis of MetS can be made if an individual has a minimum of three out of five of the conditions listed in Table 1.13
Table 1 Definition of Metabolic Syndrome According to AHA/NHLBI Revised in 2005
Metabolic syndrome is increasing in importance as a worldwide health concern. It is typically asymptomatic but significantly influences general health, mainly by increasing the risk of CV disease.
Psoriatic arthritis, Metabolic syndrome, and atherosclerosis may have overlapping inflammatory pathways and genetic predispositions in their underlying pathophysiology (Figure 1). There is an increased prevalence of chronic inflammation mediated by Th1 and Th-17 with cytokine dysregulation in PsA.16,17
Figure 1 The link between inflammation, psoriatic arthritis, and metabolic syndrome; Obesity is one of the important components of metabolic syndrome and is a well-known risk factor for psoriatic arthritis. Both obesity and PsA share a complex relationship that is likely bidirectional. Increased pro-inflammatory cytokines, secretion of adipocytokines from adipose tissue, increased of oxidative and endoplasmic reticulum stress, and dysbiosis of intestinal microbiota all play a role in the development of MetS and increase the risk of cardiovascular disease in psoriatic patients.
The pathogenesis of PsA is complicated and poorly known; The most widely acknowledged hypothesis involves an interplay between genetic predisposition and environmental exposures, resulting in immune-inflammatory pathway dysfunction. In individuals with a certain genetic history, the gut microbiota may be the missing piece in pathogenesis of PsA.
Recent evidence has emerged supporting the gut microbiomes pathogenic role in a different immune-mediated inflammatory disorders, such as diabetes mellitus, spondyloarthritis, and CV disease, the majority of which are well-known comorbidities of PsO and PsA.1820
So far, several studies on the intestinal microbiome of psoriatic patients have already been published, and four of them have demonstrated an imbalance between the two most prevalent intestinal flora, Firmicutes (F) and Bacteroidetes (B), with an increased F/B ratio.21 This kind of gut dysbiosis has been linked to diabetes, obesity, and CV disease.2224 Moreover, the presence of intestinal firmicutes was linked to a higher BMI and greater levels of the proatherogenic chemical trimethylamine-N-oxide, that raises the risk of CV events by enhancing endothelial dysfunction and interfering with cholesterol homeostasis at several levels.25,26
Furthermore, considering the comparable pathogenic aspects of obesity and psoriatic disease, both of which are characterized by similar cytokine profiles, an elevated F/B ratio might be another significant factor contributing to the pathogenesis of both of these diseases.27
Insulin resistance can be caused by a release of different cytokines, for example, tumor necrosis factor-, interleukin-17, or interleukin-6.28 Leptin is another adipokine that has a role in MetS and PsA pathogenesis.29 Increased BMI and IR have been linked to a high level of leptin.30 Endothelial dysfunction and the development of atherosclerotic plaques are caused by these inflammatory cytokines, which produce adhesion molecules and an elevated risk of CVS events in PsA.31
Metabolic syndrome has been discovered to be much more prevalent among people with PsA, PsO, and other inflammatory illnesses than in the overall population.3234 Raychaudhuri et al explored in their study, which included 105 patients with PsA that 58.1% of them diagnosed with MetS based on the AHA/NHLBI guidelines, and 61 of them satisfied a minimum of three out of five criteria for the diagnosis of the condition.35
Previous research by Haroon et al detected MetS in 44% of 283 PsA patients. They also discovered that around half of those diagnosed with MetS showed 4 MetS risk factors, with HTN (74%), increased circumference of the waist (56%), and hypertriglyceridemia (43.5%) appearing more frequently. Moreover, the study found that MetS was correlated with increased odds in patients with severe underlying disease (OR 4.47, p=0.001).7
An increasing amount of clinical research has established that PsO is frequently linked with MetS. Patients with more extensive PsO were shown to have an increased chance to have MetS than those with mild disease.3638 A large cohort study from Toronto investigated the MetS prevalence in PsA and compared them to PsO patients who did not have arthritis, finding a higher but not statistically significant prevalence of MetS in the former.39 Evidence from the literature and recent cross-sectional research indicates that those with PsA with apparent PsO had a higher frequency of MetS compared to PsA patients who did not have PsO (40.48% vs 13.16%, p = 0.006, respectively).40
The association between MetS and chronic inflammatory arthritis has also been studied. According to research and growing evidence, higher CV risk is not only attributable to an increase in conventional risk factors; it is also associated with factors involving disease and its therapy, such as chronically high pro-inflammatory cytokines and prolonged glucocorticoid therapy.41,42
A large previous study on the MetS frequency incorporated 930 individuals diagnosed with chronic inflammatory arthritis, with PsA having the highest prevalence (38%) followed by RA (20%) and ankylosing spondylitis (11%). Additionally, no significant correlation was discovered between MetS prevalence and disease longevity in the three inflammatory disorders.43 The frequency of MetS was also increasing in PsA patients than in the RA group in a large corona registry study (27% vs 19%; p = 0.02, respectively), even after demographic variables and BMI adjustments. Moreover, among the components of MetS, diabetes, hypertriglyceridemia, and high BMI were more frequent in PsA patients.33
Obesity is a critical element of MetS that can ultimately cause other conditions to develop, including IR, HTN, and increased lipids. It was described as a chronic slow inflammatory state connected to elevated pro-inflammatory cytokine production that follows a common pathway with psoriatic diseases and has a detrimental effect on disease prognosis.44
The connection between adiposity and PsA is difficult to comprehend. For instance, PsA might increase the risk of obesity by decreasing physical activity levels due to the functional and psychological restrictions of the disease. In contrast, obesity may have occurred before PsA developed, emphasizing that it may be a risk factor for the disease.45
Previous serial case studies indicated an increased likelihood of developing PsA in individuals with PsO whose BMI was higher when they were young adults, regardless of other risk factors or current BMI. Hence, patients who had high BMI at the age of 18 are threefold more likely to acquire PsA during PsO course than those with an average weight at 18. However, the study did have several significant limitations, including the way PsA cases were defined, challenges in identifying a temporal connection between the examined factors, and insufficient verified data regarding how accurately patients could remember their BMI at age 18.46
Li et al conducted a 14-year prospective study that discovered a significant link between BMI and an increased incidence of PsA. Furthermore, they found an ascending positive relationship between weight changes started at the age of 18 and PsA risk. They also discovered an analogous relationship in individuals who acquired PsO during a study follow-up.45
Additionally, a large population study showed a link between obesity and an increased chance of acquiring PsA in both PsO patients and the general population, regardless of other characteristics such as gender or age.47
Insulin resistance is a significant cardiometabolic risk for CVS disease, which causes considerable morbidity and death in individuals with inflammatory arthritis. It is uncertain whether IR is a disease-specific feature or linked to high disease activity phases. Inflammatory cytokines, including TNF, IL-6, and IL1, which have frequent involvement in PSA pathophysiology, have been linked to IR in the liver and adipose tissues, impaired insulin action in human skeletal muscle, and an increased risk of DM.48,49
An observational cohort study found a significant prevalence of IR (16%) among patients with PsA. Additionally, multiple regression analysis was conducted, the results of which indicated a significant relationship between IR and increased severity of underlying PsA disease, elevated BMI, and late-developing PsO.50 Furthermore, Eder et al discovered that diabetes mellitus was 43% more common in the PsA group than the total population. Notably, the severity of underlying psoriatic disease was identified as an important factor for developing diabetes across 11,006 overall person-years of follow-up.51
Additionally, Diabetes was shown to be more frequent in PsA patients than in sex- and age-matched persons without the disease (72%, HR 1.72) in a large population-based cohort study. Interestingly, when controlling for BMI, alcohol consumption, smoking, initial glucocorticoid utilization, and co-morbidities, the relationship was considerably decreased but remained significant (33%, HR 1.33) in PsA patients.52 As a result, the presence of inflammatory mediators cannot be entirely blamed for the development of diabetes; nevertheless, other variables, such as overweight and lifestyle habits, may also play an important role.
Furthermore, after controlling for atherosclerosis risk factors in individuals with PsA vs RA or ankylosing spondylitis, Mok et al discovered that PsA patients had more significant impairment in glucose tolerance (OR 2.58, P.001) compared to RA or ankylosing spondylitis patients.43
Hypertension is another essential component of MetS that is linked with an elevated risk of developing CVS disease. Studies indicated that HTN prevalence among PsA patients ranges from 25% to 49%.43,53,54 Furthermore, a large population study reported an increase in the frequency of HTN among those with PsA than in the general population (45.6% vs 35.8%, P < 0.0001 respectively).55 Moreover, individuals with PsA had a higher frequency of HTN than patients having only PsO (29% vs 18%, OR 1.7).56 Similarly, a study of a large cohort from the University of Toronto found also an increase in the HTN frequency among those with PsA in comparison to PsO patients with no arthritis (adjusted OR 2.17), even after controlling for known CVS traditional factors, medication history, as well as PsO duration and severity.32
In a large meta-analysis, the odds ratio of HTN was higher in individuals whose PsO was severe (OR 1.13) than those whose PsO was milder (OR1.09). Therefore, this finding emphasizes the significant contribution of inflammation-promoting arterial stiffness, which is linked to elevated hazard of CV events.57
Hypertension prevalence studies in patients diagnosed with different kinds of arthritis revealed a greater prevalence and incidence of HTN in PsA. A higher frequency (19.9% vs 18.6%) and incidence was reported in patients who had PsA than those with RA. Moreover, there was also an increased incidence of HTN among PsA patients in comparison to controls (HR 1.37) than among individuals with RA compared to controls (HR 1.16).11
Dyslipidemia is well known as an independent cardiometabolic risk for CV disease.58 The relationship between dyslipidemia and PsA has been controversial and inconsistent in previous studies. One explanation for this might be that various definitions of dyslipidemia are used throughout the research, making it impossible to compare data concerning the relative prevalence. Furthermore, it has yet to be confirmed if dyslipidemia considered as a distinct cardiometabolic risk factor for CVD in PsA beyond obesity.
According to the findings of a large PsA cohort study conducted in the Middle East, participants with PsA had a greater prevalence of hyperlipidemia than the total population (OR 1.5, P.0001).55 In addition, Kimhi et al discovered a rise in the prevalence of hypertriglyceridemia, hypercholesterolemia, and low-density lipoprotein (LDL) among PsA patients in their study (p < 0.005, p < 0.0001, and p < 0.0001, respectively).53 Based on data from a previous study on PsA, hypercholesterolemia and hypertriglyceridemia were linked with subclinical atherosclerosis.42
In large HUNT research, hypertriglyceridemia was more frequent in PsA groups when compared to controls. However, it was not statistically relevant after controlling for BMI. Other lipid values were comparable in both groups.59 In contrast, another study indicated that PsA patients had reduced total and LDL cholesterol levels but increased high-density lipoprotein (HDL) cholesterol, apolipoprotein A1 (Apo A1), and Apo B levels in PsA patients than in controls. Moreover, after controlling for BMI and hsCRP, the Apo B/Apo A1 ratio was considerably more elevated among the PsA groups than in the control groups. However, triglyceride levels were comparable across the two groups.54
Apo A1 is regarded to be a significant indicator of increased CV events with possible benefits above HDL cholesterol since it is responsible for transferring and functioning as the principal protein inhibiting atherogenesis in HDL particles.60
Apo B also carries all particles of lipoproteins that are potentially atherogenic. Although there is no consensus on the Apo B/Apo A1 ratio real use in previous studies, the cholesterol balance calculated based on the ratio has been demonstrated to be a superior measure compared with total lipids and lipoproteins levels.61 There is not yet a comprehensive understanding of the mechanisms behind these alterations in patients lipid levels with inflammatory diseases in the literature.
Additionally, multiple factors influence serum lipid levels, such as the patients diet and their usage of biologics or DMARDs. Apo B and triglyceride were elevated in those with PsA after commencing therapy with TNF inhibitor (TNFi), indicating a possible link between inflammation intensity and lipid abnormalities.62 Thus, because disease activity and anti-inflammatory medications can cause changes in lipid components, it is recommended that lipid profiling should ideally be performed when a patient is in stable condition or has entered remission.63
Metabolic syndrome raises the hazard of CV disease and atherosclerosis in PsA patients.6467 A persistent underlying inflammatory state and pathogenetic pathways are shared by MetS, atherosclerosis, and inflammatory arthropathies.68,69 A persistent low-grade inflammatory condition with imbalanced immuno-inflammatory pathways and fatty acid metabolism in the artery wall promotes endothelial dysfunction.70
An increase in the carotid artery intima-media thickness(c-IMT), a predictor of pre-atherosclerosis with greater sensitivity, has been seen in PsA. More crucially, a higher risk of inflammation has been linked to the production of atherosclerotic plaques in individuals with PsA over time.7173
Those with PsA disease had a greater likelihood of atherosclerosis, endothelial dysfunction, and c-IMT, both with or without MetS components.42,53 Atherosclerosis is also linked to the severity of both PsA and MetS components, including obesity, diabetes, and hypertension.53
In addition, those with PsA had a greater frequency of MetS and significantly higher c-IMT levels than people with PsO. Furthermore, when PsA and PsO patients with or without MetS were compared, it was shown that PsA individuals with the coexistence of MetS had the highest c-IMT levels.74
In PsA patients, it has been established that the existence of carotid atherosclerosis has a clear association with CV events, which is related to the duration of PsA as well as the inflammatory condition, and it materializes regardless of the existence of conventional CV risk factors.54,64 Thus, chronic inflammation is crucial for the advancement of atherosclerosis in PsA, which works in an independent and/or synergistic manner with traditional risk factors. Furthermore, Eder et al demonstrated that the c-IMT and carotid plaque area were better than the Framingham risk score in predicting an elevated hazard of acquiring CV events in a population of PsA, which adds credence to the hypothesis that CV morbidity is not purely mediated by standard CVD risk factors in such patients.75
Metabolic syndrome and PsA may have a shared predilection for low-grade inflammation; thus, it is crucial to find a suitable therapy that effectively decreases both clinical and subclinical chronic inflammation.
Data from previous studies support the role played by Methotrexate (MTX) in lowering inflammation in patients with chronic inflammatory conditions and consequently reducing CV risk. However, most of the data were derived from rheumatoid arthritis patients.76,77
An observational study that included patients diagnosed with inflammatory arthritis and confirmed to have endothelial dysfunction indicated that all patients experienced a marked improvement in endothelium function following six months of therapy with MTX monotherapy, MTX combined with TNFi, or only TNFi. Nevertheless, after six months of therapy, endothelial function improvement was more sustained and significant in the MTX- treated patient compared to those treated with combination therapy.78
A 12-week pilot study explored the safety of MTX in terms of glucose metabolism in PsA and MetS patients and reported no difference in glycated hemoglobin levels before and after therapy. Thus, MTX usage in this patient group is safe, with no hyperglycemic consequences. In fact, MTX seems to have a beneficial effect on glucose metabolism because commencing MTX therapy reduced glycated hemoglobin levels compared to the use of metformin.79
There is significant debate surrounding the efficacy of TNFi in MetS patients. Numerous studies have demonstrated that TNFi is less effective in obese people.80 In a large meta-analysis, a relationship was established between being an obese and inadequate response to treatment among PsA patients.80 Additionally, Obesity was linked to reduced chances of attenuating lower disease activity in PsA, highlighting the critical need of patients with PsA decreasing weight.81 In contrast, data from another study discovered that the coexistence of MetS did not influence the anti-inflammatory role of TNFi or the risk that minimal disease activity would be attained.82
In a cohort study in which the follow-up period was 24 months, Costa et al found that patients who received etanercept (ETN) and adalimumab treatment exhibited considerable improvements in metabolic syndrome components (circumference of the waist, triglycerides, HDL-C, and glucose) in comparison to MTX group.83 Furthermore, some few studies have revealed that patients managed with TNFi had a decreased chance of getting diabetes than those managed with disease-modifying antirheumatic medication (except hydroxychloroquine).84
The influence of TNFi on the cholesterol level in individuals with the underlying chronic rheumatic disease remains unclear; a comprehensive meta-analysis identified that the use of TNFi increased total cholesterol by 10% and HDL-C by 7% over six months. Moreover, LDL-C and ApoB levels have been shown to increase in small studies.85
Agca et al evaluated 118 PsA patients who had received ETN treatment for a period exceeding five years. They found that LDL-C, HDL-C, and triglyceride levels were all increased. Additionally, the ratio for ApoB to ApoAI was reduced, a finding that may have clinical implications given that an elevated ratio is linked to an increased likelihood of CVD events.86
Numerous large population-based studies have demonstrated that TNFi reduces the frequency of CV events in patient with psoriatic diseases. Armstrong et al found that PsO patients who used TNFi had a lower risk of MI than those who solely used topical therapy.87 In another study from Denmark, TNFi and MTX were linked with lower CV risk relative to topical medicines and phototherapy in PsO patients.88
In accordance with these findings, Wu and Poon found that patients with Psoriatic diseases who used TNFi had a reduced risk of new CV events than those who used other systemic medications or phototherapy.89
So, TNFi appears to have CV safety and maybe benefit, and it is favored over other treatments in patients at elevated CV risk, even though relatively little is known.
There is not enough evidence to indicate whether inhibiting IL-17 or IL12/23 improves metabolic syndrome in PsA patients. However, it has been demonstrated that being obese promotes the growth of T cells that produce IL-17 in fat and peripheral tissues. Furthermore, in patients with MetS, the IL-17R expression levels in the skeletal muscles and liver were linked to insulin resistance.56 Therefore, according to a large multi-center study, PsO patients who are obese have a lower response to secukinumab.90 However, another study found that obese PsA individuals may respond better to secukinumab than non-obese patients.91
Concern has been raised about the anti-IL-12/23 class of medications and the incidence of CV disease in PsA. However, a large, randomized trial on people with PsO found no association between ustekinumab usage and the risk of CV disease.92 More evidence on the CV safety of anti-IL-12/23 medications in psoriatic individuals is needed.
For therapy in PsA patients to be optimized, it is necessary to treat the skin and joint condition and identify and effectively manage co-morbidities.63 Much additional research must be done to fully grasp the complicated connection between PsA and MetS. The specific PsA variables linked to MetS must be identified, and it must be determined whether anti-inflammatory treatment approaches have any beneficial effect on MetS. Additionally, despite the existence of various DMARDs for the treatment of PsA, other factors, including the presence of co-morbidities, particularly MetS and CVS disease, must be taken into account when choosing suitable drugs for PsA management.93,94 The European Alliance of Associations for Rheumatology strongly encourages the adoption of lifestyle changes to mitigate CV risk factors.63 However, more investigation is needed to determine whether these strategies can augment or alter the effect of therapy on patients with MetS burden.
Psoriatic arthritis can present with various extra-articular symptoms that can manifest in isolation or together and that may take variable courses. Metabolic syndrome is intricately linked to systemic inflammation and has multiple inflammatory pathways in common with Psoriatic disease. The link between several components of MetS and psoriatic arthritis has been established, addressing the needs of screening, evaluating, and closely monitoring for co-morbidities. Therefore, rheumatologists should collaborate with other experts to detect MetS and its components as early as possible. In PsA patients with co-morbidities, the most appropriate therapy must be chosen for managing disease activity. Lifestyle changes, including smoking cessation and weight loss, are essential to decreasing CV events in PsA patients.
The author reports no conflicts of interest in this work.
1. Gudu T, Gossec L. Quality of life in psoriatic arthritis. Expert Rev Clin Immunol. 2018;14(5):405417. doi:10.1080/1744666X.2018.1468252
2. Lee S, Mendelsohn A, Sarnes E. The burden of psoriatic arthritis: a literature review from a global health systems perspective. P T. 2010;35(12):680689.
3. Rendon A, Schkel K. Psoriasis pathogenesis and treatment. Int J Mol Sci. 2019;20(6):128. doi:10.3390/ijms20061475
4. Menter A, Griffiths CEM, Tebbey PW, Horn EJ, Sterry W. Exploring the association between cardiovascular and other disease-related risk factors in the psoriasis population: the need for increased understanding across the medical community. J Eur Acad Dermatology Venereol. 2010;24(12):13711377. doi:10.1111/j.1468-3083.2010.03656.x
5. Jamnitski A, Visman IM, Peters MJL, Boers M, Dijkmans BAC, Nurmohamed MT. Prevalence of cardiovascular diseases in psoriatic arthritis resembles that of rheumatoid arthritis. Ann Rheum Dis. 2011;70(5):875LP876. doi:10.1136/ard.2010.136499
6. Crciun L, Crciun P, Buicu F. Prevalence of metabolic syndrome in psoriatic arthritis and rheumatoid arthritis. Acta Medica Marisiensis. 2014;60(5):196199. doi:10.2478/amma-2014-0041
7. Haroon M, Gallagher P, FitzGerald O. SAT0293 high prevalence of metabolic syndrome in psoriatic arthritis patients is associated with severity of underlying psoriatic disease. Ann Rheum Dis. 2013;72(Suppl3):A682A683. doi:10.1136/annrheumdis-2013-eular.2018
8. Tobin AM, Veale DJ, FitzGerald O, et al. Cardiovascular disease and risk factors in patients with psoriasis and psoriatic arthritis. J Rheumatol. 2010;37(7):13861394. doi:10.3899/jrheum.090822
9. Ogdie A, Schwartzman S, Husni ME. Recognizing and managing comorbidities in psoriatic arthritis. Curr Opin Rheumatol. 2015;27(2):118126. doi:10.1097/BOR.0000000000000152
10. McHugh NJ, Balachrishnan C, Jones SM. Progression of peripheral joint disease in psoriatic arthritis: a 5-yr prospective study. Rheumatology. 2003;42(6):778783. doi:10.1093/rheumatology/keg217
11. Radner H, Lesperance T, Accortt NA, Solomon DH. Incidence and prevalence of cardiovascular risk factors among patients with rheumatoid arthritis, psoriasis, or psoriatic arthritis. Arthritis Care Res. 2017;69(10):15101518. doi:10.1002/acr.23171
12. Alberti KGMM, Zimmet P, Shaw J. The metabolic syndrome - A new worldwide definition. Lancet. 2005;366(9491):10591062. doi:10.1016/S0140-6736(05)67402-8
13. Grundy SM, Cleeman JI, Daniels SR, et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statement. Circulation. 2005;112(17):27352752. doi:10.1161/CIRCULATIONAHA.105.169404
14. Expert Panel on Detection, Evaluation. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). JAMA. 2001;285(19):24862497. doi:10.1001/jama.285.19.2486
15. Meigs JB, Rutter MK, Sullivan LM, Fox CS, DAgostino RB, Wilson PWF. Impact of insulin resistance on risk of type 2 diabetes and cardiovascular. Diabetes Care. 2007;30(5):12191225. doi:10.2337/dc06-2484.J.B.M
16. Kruithof E, Baeten D, De Rycke L, et al. Synovial histopathology of psoriatic arthritis, both oligo- and polyarticular, resembles spondyloarthropathy more than it does rheumatoid arthritis. Arthritis Res Ther. 2005;7(3):R569. doi:10.1186/ar1698
17. Goodman WA, Levine AD, Massari JV, Sugiyama H, McCormick TS, Cooper KD. IL-6 signaling in psoriasis prevents immune suppression by regulatory T cells. J Immunol. 2009;183(5):31703176. doi:10.4049/jimmunol.0803721
18. Dao MC, Everard A, Aron-Wisnewsky J, et al. Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology. Gut. 2016;65(3):426436. doi:10.1136/gutjnl-2014-308778
19. Costello M-E, Robinson PC, Benham H, Brown MA. The intestinal microbiome in human disease and how it relates to arthritis and spondyloarthritis. Best Pract Res Clin Rheumatol. 2015;29(2):202212. doi:10.1016/j.berh.2015.08.001
20. Jin M, Qian Z, Yin J, Xu W, Zhou X. The role of intestinal microbiota in cardiovascular disease. J Cell Mol Med. 2019;23(4):23432350. doi:10.1111/jcmm.14195
21. Rinninella E, Raoul P, Cintoni M, et al. What is the healthy gut microbiota composition? A changing ecosystem across age, environment, diet, and diseases. Microorganisms. 2019;7(1):14. doi:10.3390/microorganisms7010014
22. Qin J, Li Y, Cai Z, et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature. 2012;490(7418):5560. doi:10.1038/nature11450
23. Ley RE, Backhed F, Turnbaugh P, Lozupone CA, Knight RD, Gordon JI. Obesity alters gut microbial ecology. Proc Natl Acad Sci. 2005;102(31):1107011075. doi:10.1073/pnas.0504978102
24. Cho CE, Taesuwan S, Malysheva OV, et al. Trimethylamine- N -oxide (TMAO) response to animal source foods varies among healthy young men and is influenced by their gut microbiota composition: a randomized controlled trial. Mol Nutr Food Res. 2017;61(1):1600324. doi:10.1002/mnfr.201600324
25. Wang Z, Klipfell E, Bennett BJ, et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature. 2011;472(7341):5763. doi:10.1038/nature09922
26. Yan D, Issa N, Afifi L, Jeon C, Chang H-W, Liao W. The role of the skin and gut microbiome in psoriatic disease. Curr Dermatol Rep. 2017;6(2):94103. doi:10.1007/s13671-017-0178-5
27. Rodrguez-Cerdeira C, Cordeiro-Rodrguez M, Carnero-Gregorio M, et al. Biomarkers of inflammation in obesity-psoriatic patients. Mediators Inflamm. 2019;2019:114. doi:10.1155/2019/7353420
28. Trayhurn P, Wood IS. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr. 2004;92(3):347355. doi:10.1079/bjn20041213
29. Hutcheson J. Adipokines influence the inflammatory balance in autoimmunity. Cytokine. 2015;75(2):272279. doi:10.1016/j.cyto.2015.04.004
30. Chiricozzi A, Raimondo A, Lembo S, et al. Crosstalk between skin inflammation and adipose tissue-derived products: pathogenic evidence linking psoriasis to increased adiposity. Expert Rev Clin Immunol. 2016;12(12):12991308. doi:10.1080/1744666X.2016.1201423
31. Hong J, Maron DJ, Shirai T, Weyand CM. Accelerated atherosclerosis in patients with chronic inflammatory rheumatologic conditions. Int J Clin Rheumtol. 2015;10(5):365381. doi:10.2217/ijr.15.33
32. Husted JA, Thavaneswaran A, Chandran V, et al. Cardiovascular and other comorbidities in patients with psoriatic arthritis: a comparison with patients with psoriasis. Arthritis Care Res. 2011;63(12):17291735. doi:10.1002/acr.20627
33. Labitigan M, Bahe-Altuntas A, Kremer JM, et al. Higher rates and clustering of abnormal lipids, obesity, and diabetes mellitus in psoriatic arthritis compared with rheumatoid arthritis. Arthritis Care Res. 2014;66(4):600607. doi:10.1002/acr.22185
34. Loganathan A, Kamalaraj N, El-Haddad C, Pile K. Systematic review and meta-analysis on prevalence of metabolic syndrome in psoriatic arthritis, rheumatoid arthritis and psoriasis. Int J Rheum Dis. 2021;24(9):11121120. doi:10.1111/1756-185X.14147
35. Raychaudhuri SK, Chatterjee S, Nguyen C, Kaur M, Jialal I, Raychaudhuri SP. Increased prevalence of the metabolic syndrome in patients with psoriatic arthritis. Metab Syndr Relat Disord. 2010;8(4):331334. doi:10.1089/met.2009.0124
36. Rodrguez-Ziga MJM, Garca-Perdomo HA. Systematic review and meta-analysis of the association between psoriasis and metabolic syndrome. J Am Acad Dermatol. 2017;77(4):657666.e8. doi:10.1016/j.jaad.2017.04.1133
37. Armstrong AW, Harskamp CT, Armstrong EJ. The association between psoriasis and obesity: a systematic review and meta-analysis of observational studies. Nutr Diabetes. 2012;2(12):e54. doi:10.1038/nutd.2012.26
38. Caroppo F, Galderisi A, Moretti C, Ventura L, Belloni Fortina A. Prevalence of psoriasis in a cohort of children and adolescents with type 1 diabetes. J Eur Acad Dermatology Venereol. 2021;35(9):13. doi:10.1111/jdv.17318
39. Eder L, Jayakar J, Pollock R, et al. Serum adipokines in patients with psoriatic arthritis and psoriasis alone and their correlation with disease activity. Ann Rheum Dis. 2013;72(12):19561961. doi:10.1136/annrheumdis-2012-202325
40. Caso F, Del Puente A, Oliviero F, et al. Metabolic syndrome in psoriatic arthritis: the interplay with cutaneous involvement. Evidences from literature and a recent cross-sectional study. Clin Rheumatol. 2018;37(3):579586. doi:10.1007/s10067-017-3975-0
41. Del Rincn I, Freeman GL, Haas RW, OLeary DH, Escalante A. Relative contribution of cardiovascular risk factors and rheumatoid arthritis clinical manifestations to atherosclerosis. Arthritis Rheum. 2005;52(11):34133423. doi:10.1002/art.21397
42. Gonzalez-juanatey C, Llorca J, Amigo-Diaz E, Dierssen T, Martin J, Gonzalez-Gay MA. High prevalence of subclinical atherosclerosis in psoriatic arthritis patients without clinically evident cardiovascular disease or classic atherosclerosis risk factors. Arthritis Rheum. 2007;57(6):10741080. doi:10.1002/art.22884
43. Mok CC, Ko GTC, Ho LY, Yu KL, Chan PT, To CH. Prevalence of atherosclerotic risk factors and the metabolic syndrome in patients with chronic inflammatory arthritis. Arthritis Care Res. 2011;63(2):195202. doi:10.1002/acr.20363
Original post:
Metabolic syndrome and its components in psoriatic arthritis | OARRR - Dove Medical Press
Posted in Psoriasis
Comments Off on Metabolic syndrome and its components in psoriatic arthritis | OARRR – Dove Medical Press







