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Monthly Archives: January 2022
ContraFect Announces Award from the Cystic Fibrosis Foundation to Evaluate Exebacase as a Potential Treatment for Serious MRSA Lung Infections…
Posted: January 9, 2022 at 3:59 pm
YONKERS, N.Y., Jan. 06, 2022 (GLOBE NEWSWIRE) -- ContraFect Corporation (Nasdaq: CFRX), a late clinical-stage biotechnology company focused on the discovery and development of direct lytic agents (DLAs), including lysins and amurin peptides, as new medical modalities for the treatment of life-threatening, antibiotic-resistant infections, today announces that it has received an additional award from the Cystic Fibrosis Foundation (CFF). This contract award will support investigation of the potential utility of exebacase for treating serious lung infections caused by methicillin-resistant Staphylococcus aureus (MRSA) in people with cystic fibrosis (CF). The program, titled Nonclinical Assessment of Lysin Exebacase for Treating MRSA Infections in CF will, over the course of 12 months, evaluate the in vitro activity of exebacase against bacterial specimens obtained from CF patients.
MRSA lung infections lead to potential acceleration in the decline in lung function and are an independent predictor of mortality in the CF population. Eradication of persistent MRSA in the lungs of CF patients remains a major challenge despite current antibiotic therapy. Thus, there is a pressing unmet need for new medical modalities and novel therapeutic approaches to address the serious health threat to CF patients, said Cara Cassino, M.D., Executive Vice President of Research & Development and Chief Medical Officer of ContraFect. We are pleased to have the opportunity to work with the CF Foundation again in order to evaluate the potential utility of exebacase as such a treatment for MRSA lung infections in this vulnerable population, continued Dr. Cassino.
Pathogenic bacteria are known to be a major contributor to CF disease. The lungs of CF patients are typically colonized with pathogenic bacteria, that damage the epithelial surfaces. The growth of highly resistant Staph aureus or Pseudomonas aeruginosa, two of the most common causes of lung infections in CF patients, is associated with further epithelial surface damage, and potentially an overall decline in pulmonary function. MRSA has become more prevalent in the CF population in recent years, increasing from 9.2 percent in 2002 to 25.9 percent in 2017. MRSA plays a role in pulmonary exacerbations of CF that may require hospitalization and treatment with systemic antibiotics. Chronic lung infections are known to be the main cause of lung function deterioration, and ultimately mortality, in CF patients.
Story continues
The award from the Cystic Fibrosis Foundation will provide ContraFect with financial support for research activities. Further financial details were not disclosed. ContraFect retains global rights for exebacase and its entire DLA therapeutic pipeline.
About Cystic Fibrosis
Cystic Fibrosis (CF) is a rare, life-shortening genetic disease affecting approximately 75,000 people worldwide. CF is a progressive, multi-system disease that affects the lungs, liver, GI tract, sinuses, sweat glands, pancreas and reproductive tract. People with CF are prone to infections of the lungs because they develop abnormally thick, sticky mucus which traps germs in their airways and therefore does not have the same infection-fighting properties as normal mucus. This abnormal mucus provides an ideal environment for bacteria to form protective layers -- known as biofilms -- that make them more difficult to kill. Many individuals also suffer severe side effects from long-term antibiotic use, such as hearing loss, and are at increased risk of lung function deterioration and ultimately mortality.
About Exebacase (CF-301):
Exebacase is an anti-staphylococcal recombinantly-produced lysin (cell wall hydrolase enzyme) with potent bactericidal activity against Staph aureus, a major cause of bloodstream infections (BSIs) also known as bacteremia. It is the first lysin to enter clinical studies in the U.S. and was granted Breakthrough Therapy designation by the FDA for the treatment of MRSA bloodstream infections, including right-sided endocarditis, when used in addition to SOC anti-staphylococcal antibiotics.
Exebacase is currently being studied in the Phase 3 DISRUPT superiority design study of exebacase in patients with Staph aureus bacteremia, including right-sided endocarditis. In the Companys Phase 2 study of exebacase, a pre-specified analysis of MRSA-infected patients showed that the clinical responder rate at Day 14 in patients treated with exebacase was nearly 43-percentage points higher than in patients treated with SOC antibiotics alone (74.1% for patients treated with exebacase compared to 31.3% for patients treated with SOC antibiotics alone (p=0.010)). In addition to the higher rate of clinical response, MRSA-infected patients treated with exebacase showed a 21-percentage point reduction in 30-day all-cause mortality (p=0.056), a four-day lower median length of hospital stay and meaningful reductions in hospital readmission rates.
Exebacase has the potential to be a first-in-class treatment for Staph aureus bacteremia. Exebacase was licensed from The Rockefeller University and is being developed at ContraFect.
About ContraFect
ContraFect is a biotechnology company focused on the discovery and development of DLAs, including lysins and amurin peptides, as new medical modalities for the treatment of life-threatening, antibiotic-resistant infections. An estimated 700,000 deaths worldwide each year are attributed to antimicrobial-resistant infections. We intend to address life threatening infections using our therapeutic product candidates from our platform of DLAs, which include lysins and amurin peptides. Lysins are a new class of DLAs which are recombinantly produced antimicrobial proteins with a novel mechanism of action associated with the rapid killing of target bacteria, eradication of biofilms and synergy with conventional antibiotics. Amurin peptides are a novel class of DLAs which exhibit broad-spectrum activity against a wide range of antibiotic-resistant Gram-negative pathogens, including P. aeruginosa, Acinetobacter baumannii, and Enterobacter species. We believe that the properties of our lysins and amurin peptides will make them suitable for targeting antibiotic-resistant organisms, such as MRSA and P. aeruginosa, which can cause serious infections such as bacteremia, pneumonia and osteomyelitis. We have completed a Phase 2 clinical trial for the treatment of Staph aureus bacteremia, including endocarditis, with our lead lysin candidate, exebacase, which is the first lysin to enter clinical studies in the U.S. Exebacase, currently being studied in a pivotal Phase 3 clinical study, was granted Breakthrough Therapy designation by the FDA for the treatment of MRSA bloodstream infections, including right-sided endocarditis, when used in addition to SOC anti-staphylococcal antibiotics.
Follow ContraFect on Twitter @ContraFectCorp and LinkedIn.
Forward-Looking Statements
This press release contains, and our officers and representatives may make from time to time, forward-looking statements within the meaning of the U.S. federal securities laws. Forward-looking statements can be identified by words such as projects, may, will, could, would, should, believes, expects, anticipates, estimates, intends, plans, potential, promise or similar references to future periods. Examples of forward-looking statements in this release include, without limitation, statements regarding: the potential for exebacase to treat serious MRSA lung infections associated with CF, ContraFects ability to discover and develop DLAs as new medical modalities for the treatment of life-threatening, antibiotic-resistant infections, statements regarding the award, CF and CFF, statements made by Dr. Cassino, whether the award will provide ContraFect with financial support for research activities, whether exebacase has the potential to be a first-in-class treatment for Staph aureus bacteremia, ContraFects ability to address life-threatening infections using its DLA platform, whether lysins are a new class of DLAs which are recombinantly produced, antimicrobial proteins with a novel mechanism of action associated with the rapid killing of target bacteria, eradication of biofilms and synergy with conventional antibiotics, whether amurins are a novel class of DLAs which exhibit broad-spectrum activity against a wide range of antibiotic-resistant Gram-negative pathogens, and whether the properties of ContraFects lysins and amurins will make them suitable for targeting antibiotic-resistant organisms, such as MRSA and P. aeruginosa. Forward-looking statements are statements that are not historical facts, nor assurances of future performance. Instead, they are based on ContraFects current beliefs, expectations and assumptions regarding the future of its business, future plans, strategies, projections, anticipated events and trends, the economy and other future conditions. Because forward-looking statements relate to the future, they are subject to inherent risks, uncertainties and changes in circumstances that are difficult to predict and many of which are beyond ContraFects control, including the occurrence of any adverse events related to the discovery, development and commercialization of ContraFects product candidates such as unfavorable clinical trial results, insufficient supplies of drug products, the lack of regulatory approval, or the unsuccessful attainment or maintenance of patent protection and other important risks detailed under the caption Risk Factors in ContraFect's filings with the Securities and Exchange Commission. Actual results may differ from those set forth in the forward-looking statements. Important factors that could cause actual results to differ include, among others, our ability to develop treatments for drug-resistant infectious diseases. Any forward-looking statement made by ContraFect in this press release is based only on information currently available and speaks only as of the date on which it is made. Except as required by applicable law, ContraFect expressly disclaims any obligations to publicly update any forward-looking statements, whether written or oral, that may be made from time to time, whether as a result of new information, future developments or otherwise.
Investor Relations Contacts:
Michael MessingerContraFect CorporationTel: 914-207-2300Email: mmessinger@contrafect.com
Media:
Jules AbrahamCORE IRTel: 917-885-7378Email: Julesa@coreir.com
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Why Can’t People Hear What Jordan Peterson Is Actually …
Posted: at 3:58 pm
My first introduction to Jordan B. Peterson, a University of Toronto clinical psychologist, came by way of an interview that began trending on social media last week. Peterson was pressed by the British journalist Cathy Newman to explain several of his controversial views. But what struck me, far more than any position he took, was the method his interviewer employed. It was the most prominent, striking example Ive seen yet of an unfortunate trend in modern communication.
First, a person says something. Then, another person restates what they purportedly said so as to make it seem as if their view is offensive, hostile, or absurd.
Twitter, Facebook, Tumblr, and various Fox News hosts all feature and reward this rhetorical technique. And the Peterson interview has so many moments of this kind that each successive example calls attention to itself until the attentive viewer cant help but wonder what drives the interviewer to keep inflating the nature of Petersons claims, instead of addressing what he actually said.
This isnt meant as a global condemnation of this interviewers quality or past work. As with her subject, I havent seen enough of it to render any overall judgmentand it is sometimes useful to respond to an evasive subject with an unusually blunt restatement of their views to draw them out or to force them to clarify their ideas.
Perhaps she has used that tactic to good effect elsewhere. (And the online attacks to which shes been subjected are abhorrent assaults on decency by people who are perpetrating misbehavior orders of magnitude worse than hers.)
But in the interview, Newman relies on this technique to a remarkable extent, making it a useful illustration of a much broader pernicious trend. Peterson was not evasive or unwilling to be clear about his meaning. And Newmans exaggerated restatements of his views mostly led viewers astray, not closer to the truth.
* * *
Peterson begins the interview by explaining why he tells young men to grow up and take responsibility for getting their lives together and becoming good partners. He notes he isnt talking exclusively to men, and that he has lots of female fans.
Whats in it for the women, though? Newman asks.
Well, what sort of partner do you want? Peterson says. Do you want an overgrown child? Or do you want someone to contend with who is going to help you?
So youre saying, Newman retorts, that women have some sort of duty to help fix the crisis of masculinity. But thats not what he said. He posited a vested interest, not a duty.
Women deeply want men who are competent and powerful, Peterson goes on to assert. And I dont mean power in that they can exert tyrannical control over others. Thats not power. Thats just corruption. Power is competence. And why in the world would you not want a competent partner? Well, I know why, actually, you cant dominate a competent partner. So if you want domination
The interviewer interrupts, So youre saying women want to dominate, is that what youre saying?
The next section of the interview concerns the pay gap between men and women, and whether it is rooted in gender itself or other nondiscriminatory factors:
Newman: that 9 percent pay gap, thats a gap between median hourly earnings between men and women. That exists.
Peterson: Yes. But theres multiple reasons for that. One of them is gender, but thats not the only reason. If youre a social scientist worth your salt, you never do a univariate analysis. You say women in aggregate are paid less than men. Okay. Well then we break its down by age; we break it down by occupation; we break it down by interest; we break it down by personality.
Newman: But youre saying, basically, it doesnt matter if women arent getting to the top, because thats what is skewing that gender pay gap, isnt it? Youre saying thats just a fact of life, women arent necessarily going to get to the top.
Peterson: No, Im not saying it doesnt matter, either. Im saying there are multiple reasons for it.
Newman: Yeah, but why should women put up with those reasons?
Peterson: Im not saying that they should put up with it! Im saying that the claim that the wage gap between men and women is only due to sex is wrong. And it is wrong. Theres no doubt about that. The multivariate analysis have been done. So let me give you an example
The interviewer seemed eager to impute to Peterson a belief that a large, extant wage gap between men and women is a fact of life that women should just put up with, though all those assertions are contrary to his real positions on the matter.
Throughout this next section, the interviewer repeatedly tries to oversimplify Petersons view, as if he believes one factor he discusses is all-important, and then she seems to assume that because Peterson believes that given factor helps to explain a pay gap between men and women, he doesnt support any actions that would bring about a more equal outcome.
Her surprised question near the end suggests earnest confusion:
Peterson: Theres a personality trait known as agreeableness. Agreeable people are compassionate and polite. And agreeable people get paid less than disagreeable people for the same job. Women are more agreeable than men.
Newman: Again, a vast generalization. Some women are not more agreeable than men.
Peterson: Thats true. And some women get paid more than men.
Newman: So youre saying by and large women are too agreeable to get the pay raises that they deserve.
Peterson: No, Im saying that is one component of a multivariate equation that predicts salary. It accounts for maybe 5 percent of the variance. So you need another 18 factors, one of which is gender. And there is prejudice. Theres no doubt about that. But it accounts for a much smaller portion of the variance in the pay gap than the radical feminists claim.
Newman: Okay, so rather than denying that the pay gap exists, which is what you did at the beginning of this conversation, shouldnt you say to women, rather than being agreeable and not asking for a pay raise, go ask for a pay raise. Make yourself disagreeable with your boss.
Peterson: But I didnt deny it existed, I denied that it existed because of gender. See, because Im very, very, very careful with my words.
Newman: So the pay gap exists. You accept that. I mean the pay gap between men and women existsbut youre saying its not because of gender, its because women are too agreeable to ask for pay raises.
Peterson: Thats one of the reasons.
Newman: Okay, so why not get them to ask for a pay raise? Wouldnt that be fairer?
Peterson: Ive done that many, many, many times in my career. So one of the things you do as a clinical psychologist is assertiveness training. So you might sayoften you treat people for anxiety, you treat them for depression, and maybe the next most common category after that would be assertiveness training. So Ive had many, many women, extraordinarily competent women, in my clinical and consulting practice, and weve put together strategies for their career development that involved continual pushing, competing, for higher wages. And often tripled their wages within a five-year period.
Newman: And you celebrate that?
Peterson: Of course! Of course!
Another passage on gender equality proceeded thusly:
Newman: Is gender equality a myth?
Peterson: I dont know what you mean by the question. Men and women arent the same. And they wont be the same. That doesnt mean that they cant be treated fairly.
Newman: Is gender equality desirable?
Peterson: If it means equality of outcome then it is almost certainly undesirable. Thats already been demonstrated in Scandinavia. Men and women wont sort themselves into the same categories if you leave them to do it of their own accord. Its 20 to 1 female nurses to male, something like that. And approximately the same male engineers to female engineers. Thats a consequence of the free choice of men and women in the societies that have gone farther than any other societies to make gender equality the purpose of the law. Those are ineradicable differencesyou can eradicate them with tremendous social pressure, and tyranny, but if you leave men and women to make their own choices you will not get equal outcomes.
Newman: So youre saying that anyone who believes in equality, whether you call them feminists or whatever you want to call them, should basically give up because it aint going to happen.
Peterson: Only if theyre aiming at equality of outcome.
Newman: So youre saying give people equality of opportunity, thats fine.
Peterson: Its not only fine, its eminently desirable for everyone, for individuals as well as societies.
Newman: But still women arent going to make it. Thats what youre really saying.
That is not what hes really saying!
In this next passage Peterson shows more explicit frustration than at any other time in the program with being interviewed by someone who refuses to relay his actual beliefs:
Newman: So you dont believe in equal pay.
Peterson: No, Im not saying that at all.
Newman: Because a lot of people listening to you will say, Are we going back to the dark ages?
Peterson: Thats because youre not listening, youre just projecting.
Newman: Im listening very carefully, and Im hearing you basically saying that women need to just accept that theyre never going to make it on equal termsequal outcomes is how you defined it.
Peterson: No, I didnt say that.
Newman: If I was a young woman watching that, I would go, well, I might as well go play with my Cindy dolls and give up trying to go school, because Im not going to get the top job I want, because theres someone sitting there saying, its not possible, its going to make you miserable.
Peterson: I said that equal outcomes arent desirable. Thats what I said. Its a bad social goal. I didnt say that women shouldnt be striving for the top, or anything like that. Because I dont believe that for a second.
Newman: Striving for the top, but youre going to put all those hurdles in their way, as have been in their way for centuries. And thats fine, youre saying. Thats fine. The patriarchal system is just fine.
Peterson: No! I really think thats silly! I do, I think thats silly.
He thinks it is silly because he never said that the patriarchal system is just fine or that he planned to put lots of hurdles in the way of women, or that women shouldnt strive for the top, or that they might as well drop out of school, because achieving their goals or happiness is simply not going to be possible.
The interviewer put all those words in his mouth.
The conversation moves on to other topics, but the pattern continues. Peterson makes a statement. And then the interviewer interjects, So youre saying and fills in the rest with something that is less defensible, or less carefully qualified, or more extreme, or just totally unrelated to his point. I think my favorite example comes when they begin to talk about lobsters. Heres the excerpt:
Peterson: Theres this idea that hierarchical structures are a sociological construct of the Western patriarchy. And that is so untrue that its almost unbelievable. I use the lobster as an example: We diverged from lobsters evolutionarily history about 350 million years ago. And lobsters exist in hierarchies. They have a nervous system attuned to the hierarchy. And that nervous system runs on serotonin just like ours. The nervous system of the lobster and the human being is so similar that anti-depressants work on lobsters. And its part of my attempt to demonstrate that the idea of hierarchy has absolutely nothing to do with sociocultural construction, which it doesnt.
Newman: Let me get this straight. Youre saying that we should organize our societies along the lines of the lobsters?
Yes, he proposes that we all live on the sea floor, save some, who shall go to the seafood tanks at restaurants. Its laughable. But Peterson tries to keep plodding along.
Peterson: Im saying it is inevitable that there will be continuities in the way that animals and human beings organize their structures. Its absolutely inevitable, and there is one-third of a billion years of evolutionary history behind that Its a long time. You have a mechanism in your brain that runs on serotonin thats similar to the lobster mechanism that tracks your statusand the higher your status, the better your emotions are regulated. So as your serotonin levels increase you feel more positive emotion and less negative emotion.
Newman: So youre saying like the lobsters, were hardwired as men and women to do certain things, to sort of run along tram lines, and theres nothing we can do about it.
Where did she get that extreme and theres nothing we can do about it? Peterson has already said that hes a clinical psychologist who coaches people to change how they relate to institutions and to one another within the constraints of human biology. Of course he believes that there is something that can be done about it.
He brought up the lobsters only in an attempt to argue that one thing we cant do is say that hierarchical organization is a consequence of the capitalist patriarchy.
At this point, were near the end of the interview. And given all that preceded it, Newmans response killed me. Again, she takes an accusatory tack with her guest:
Newman: Arent you just whipping people up into a state of anger?
Peterson: Not at all.
Newman: Divisions between men and women. Youre stirring things up.
Actually, one of the most important things this interview illustratesone reason it is worth noting at lengthis how Newman repeatedly poses as if she is holding a controversialist accountable, when in fact, for the duration of the interview, it is she that is stirring things up and whipping people into a state of anger.
At every turn, she is the one who takes her subjects words and makes them seem more extreme, or more hostile to women, or more shocking in their implications than Petersons remarks themselves support. Almost all of the most inflammatory views that were aired in the interview are ascribed by Newman to Peterson, who then disputes that she has accurately characterized his words.
There are moments when Newman seems earnestly confused, and perhaps is. And yet, if it were merely confusion, would she consistently misinterpret him in the more scandalous, less politically correct, more umbrage-stoking direction?
To conclude, this is neither an endorsement nor a condemnation of Petersons views. It is an argument that the effects of the approach used in this interview are pernicious.
For one, those who credulously accept the interviewers characterizations will emerge with the impression that a prominent academic holds troubling views that, in fact, he does not actually believe or advocate. Some will feel needlessly troubled. And distorted impressions of what figures like Peterson mean by the words that they speak can only exacerbate overall polarization between their followers and others, and sap their critics of credibility to push back where they are wrong.
Lots of culture-war fights are unavoidablethat is, they are rooted in earnest, strongly felt disagreements over the best values or way forward or method of prioritizing goods. The best we can do is have those fights, with rules against eye-gouging.
But there is a way to reduce needless division over the countless disagreements that are inevitable in a pluralistic democracy: get better at accurately characterizing the views of folks with differing opinions, rather than egging them on to offer more extreme statements in interviews; or even worse, distorting their words so that existing divisions seem more intractable or impossible to tolerate than they are. That sort of exaggeration or hyperbolic misrepresentation is epidemicand addressing it for everyones sake is long overdue.
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Jordan Peterson says Joe Rogan beats ratings of legacy media because ‘he doesn’t lie’ – Washington Examiner
Posted: at 3:58 pm
Canadian psychology professor and author Jordan Peterson responded to ratings numbers showing that Joe Rogan's podcast has more than triple the number of views of legacy media prime-time shows such as The Rachel Maddow Show and Tucker Carlson Tonight.
In response to Q3 media ratings posted to Twitter, Peterson argued that the reason Rogan's show beats cable talk shows in the ratings is because he "doesn't lie."
FED UP JOE ROGAN JOINS GETTR AFTER TWITTER BANS DR. ROBERT MALONE AND REP. MARJORIE TAYLOR GREENE
"That's because he doesn't lie. Or talk down to his audience. Or manipulate for his own narrow advantage," Peterson tweeted. "Go @joerogan. See you in three weeks in Austin."
JORDAN PETERSON SAYS HE WAS LIED TO: 'I'LL GET THE VACCINE IF YOU F***ING LEAVE ME ALONE. AND DID THAT WORK? NO'
The ratings chart, based on data from Nielsen Holdings and Spotify, shows that Rogan's show is ranked No. 1 with an average of 11 million viewers per show, followed by Tucker Carlson Tonight, with 3.24 million per show, and The Five, with 2.98 million viewers per show.
CLICK HERE TO READ MORE FROM THE WASHINGTON EXAMINER
Rogan often has controversial guests on his show. He recently had the embattled Dr. Robert Malone, a contributor to the research that created mRNA vaccine technology, on his show to discuss the potential risk involved with the coronavirus vaccine as well as alleged malpractice by the Centers for Disease Control and Prevention, Pfizer, and other health authorities in relation to the COVID-19 response.
Malone was banned from Twitter after making posts that could have promoted vaccine hesitancy.
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Cal Basketball: Unbeaten USC Pulls Away From Bears in the Second Half – CalBearsMaven
Posted: at 3:58 pm
No. 7 USC is the fourth-tallest team in the country and the Trojans used that length to stay undefeated at the expense of Cal on Thursday night.
The Trojans converted eight offensive rebounds into 10 second-chance points in the first half. Then they merely attacked basket, making 11 of their first 16 shots in the second half on the way to a 77-63 victory at Haas Pavilion.
By the time it was over, the Trojans had scored 50 points in the paint.
"We didn't play well enough to beat a Top-10 team tonight," Cal coach Mark Fox says in the video at the top of this story. "We simply didn't rebound the ball in the first half. And in the second half we didn't force enough stops to even have our rebounding exposed."
Cal (9-5, 2-2 Pac-12) had won five straight games and nine in a row at home. And Bears played well during long stretches of the game.
They simply had no answer for the Trojans physical advantage, although Cal guard Jordan Shepherd said the Bears simply didn't measure up defensively.
USC (13-0, 3-0), with seven players standing at least 6-foot-9, overpowered the Bears in the second half. Isaiah Mobley, a 6-foot-10 forward, put up 19 points scoring on dunks, drives while also making both of his 3-point attempts.
The Trojans, who hadn't played in 18 days, used an 8-0 to push their lead to 46-35 on a drive by Ethan Anderson with 14:25 left. But the Bears did not go away.
Back-to-back 3-pointers by Jordan Shepherd and Jalen Celestine and a pair of free throws by Shepherd pulled Cal within 52-48 with just over 10 minutes left.
The Bears got no closer, and when Joshua Morgan scored a layup with 5:18 left the Trojans had their biggest lead of the night at 65-53. That margin reached 15 points before the Bears closed a bit in the final minutes.
Drew Peterson scored 17 points and Boogie Ellis had 14 points for USC, which shot 64 percent in the second half. Peterson and Mobley each had nine rebounds.
Grant Anticevich, who led the Bears with 19 points, says in the video below he feels like the Bears gave the game away. Cal, playing two top-10 teams in the same week for the first time since 1975, takes on No. 5 UCLA on Saturday
Shepherd, limited in the first half by two early fouls, scored 15 for the Bears and Andre Kelly had 13 points and 11 rebounds. Celestine added 10 points. Point guard Joel Brown dished a career-high nine assists and had zero turnovers in 36 minutes on the floor.
The Bears shot 40.7 percent from the field, the highest percentage any opponent has managed this season against a USC team that is second nationally, allowing just 35 percent.
Cal trailed 36-31 at halftime after allowing the Trojans to convert eight offensive rebounds into 10 second-chance points. They used their length to build a 23-14 rebounding advantage in the first 20 minutes.
Cal shot well early in a half that had 10 lead changes but the Bears closed the half by making just one of eight attempts to finish the period at 38 percent.
The Bears last lead the half was 17-16 after Celestine converted a drive to the basket with 11:22 left.
The Trojans built their biggest lead of the half with an 8-0 run that made it 26-20 with 8 minutes left. They scored two of those basket following offensive rebounds and another off a steal that became a breakaway dunk.
Kelly had eight points and six rebounds for the Bears at halftime and Anticevich had eight points and six rebounds. Celestine came off the bench to score seven.
Mobley had 12 points and six rebounds for USC and Peterson posted eight and six.
Cover photo of USC's Drew Peterson passing around Cal's Andre Kelly by D. Ross Cameron, USA Today
Follow Jeff Faraudo of Cal Sports Report on Twitter: @jefffaraudo
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A plea to save the Freedom House building – BayStateBanner
Posted: at 3:58 pm
A key piece of Bostons civil rights history faces demolition: is it too late to save the Freedom House?
In a residential pocket of Bostons Grove Hall neighborhood where Roxbury meets Dorchester, an old brick building sits on a fenced-in lot, its wooden steps buckled and rotted, peeling paint visible through rusted metal window frames.
The longtime home of Freedom Housenow a decaying, neglected structure on Crawford streetplayed a critical role in the local civil rights movement, serving as a meeting place for advocates for equality and the neighboring community starting in the 1950s.
Freedom House founders Otto and Muriel Snowden. PHOTO: NORTHEASTERN UNIVERSITY ARCHIVE
One mile away from the house where Malcolm X spent part of his youth, Freedom House founders Otto and Muriel Snowden held court with Martin Luther King Jr. and other civil rights leaders, local elected officials, stakeholders in the fight against racism in Boston and President John F. Kennedy. Decades before a 1974 federal court order, social workers at the Freedom House in Roxbury started a movement of freedom schools and protests to counter segregation and racism in Boston public schools.
Currently slated for demolition, the building constructed in 1900 is a civil rights-era time capsule the city seems to have forgotten, though a recent application to delay its destruction raises the question: Is it too late to save the Freedom House?
Katrina Shaw, Freedom Houses executive director, says the nonprofit spent a decade trying to secure funding for renovations to save the old building.
But people werent giving. People didnt want to give, she told GBH News. People love the idea of Freedom House and what it meant to the city, but no one would really put their financial wherewithal behind it.
In 2010, the state awarded Freedom House a $1 million challenge grant to restore its former home and renovate a newer location across the street, a former public library branch where the organization currently operates. Then-chief executive Gail Snowden, the founders daughter, put out a call for help with fundraising to preserve the structure.
The current Freedom House building in the former Grove Hall Branch library building on Crawford Street. PHOTO: TORI BEDFORD
Our love for the building made us hold on to it for so long at a financial cost, Shaw said. If we were able to preserve it, we would. But when it starts to cannibalize your own ask to actually do the mission of Freedom House, then I think you have to make hard decisions, just like you would never choose your house over your child.
Last year, Snowden gave her blessing to Shaw and the current Freedom House managers to sell the building. The historic site was sold to a development company started by the late Dorchester native John Corcoran for $1.5 million, a sum that will go towards programs at the new location, where the foundation primarily focuses on academic, financial and social opportunities for college-bound students. Hoping to break ground in 2023, the developer plans to construct mixed-income housing and a memorial on the site to honor the work of the founders.
This decision was hard to make, and it wasnt made in haste, Shaw said. And if someone wanted to give Freedom House, like $20 million, I would restore it. I will do that tomorrow. I will do it five minutes from now. That had been our plea all along in terms of being able to raise money, but we couldnt.
The former Freedom House building sits a few blocks away from dozens of historic landmarks, structures from the Revolutionary War and homes of English settlers and church deacons. Its one of a handful of landmarks from the civil rights era remaining in Boston and a symbol of the fight for equal rightsone that may soon disappear.
You know, its interesting, no one has called me about it, Byron Rushing, president of the Roxbury Historical Society, told GBH News. We pretty much respond to people raising the issue. Can we save this building? What do we have to do to save this building? No one has asked me that question.
The current segregation in Bostonand racial wealth gapleads to the neglect of landmarks in predominantly Black neighborhoods like the Freedom House, Rushing said.
People dont know that history, outside of Roxbury, and new Roxbury people dont know about the history, he said. If this building was on the Black Heritage Trail, we would get a lot more publicity about it.
Christopher Martell, a UMass Boston professor who lives in Dorchester, teaches his students about Bostons educational history through a tour that begins at the old Freedom House, an important nerve center during the violent reaction to school desegregation.
Its particularly important because it tells a much longer story than just Boston busing, Martell told GBH News. Most of the students from the suburbs of Boston have no idea about its history. They dont even really know much about the civil rights struggle in Roxbury and Dorchester during the 50s and 60s.
Last month, Martell wrote a letter to the Boston Landmarks Commission, arguing for the Freedom House to be preserved as a protected landmark.
Shortly after Martells letter, the commission received an application to delay the demolition, citing both the significance of the Freedom House during the civil rights movement and the buildings use as a Hebrew Teachers College beginning in 1920.
The commission preliminarily deemed the Freedom House historically significant, according to a commission spokesperson. Once the city agency receives two alternatives to demolition and holds a public community meeting, it will schedule a formal hearing.
A delay from the landmarks commission doesnt guarantee that demolition will be blocked, but it could shine a light on the issue, a development Martell hopes will help the city find another solution.
The Landmarks Commission only has so much power, he said, but this is a place where advocacy is really important, because it would be harder for a developer to just take down the building if there was a collective movement to push back against that.
Shaw seems resigned about saying goodbye, knowing that the core mission will continue, no matter what building its in.
The spirit of Freedom House, the work of Freedom House, its here and its going on, Shaw said, gesturing out to the bustling office, where students took classes on laptops and served lunch to the Goldenaires of Freedom House, a program for seniors.
Goldenaires Coordinator Jumaada Abdal-Khallaq Henry Smith, a Roxbury native who attended Goldenaires meetings with her mother in the old building, says shes sad to let go of the space where she spent so much of her childhood.
I am a victim of eminent domain, so I cant show my kids where I used to live because our house is not there anymore, Abdal-Khallaq Henry Smith told GBH News. I hate to see the loss of something that is historical because my mom was breathing in that air, and all those Goldenaires, you know. Theres something about being able to hold on to something, for your childrens children to see it.
Tori Bedford is a reporter at GBH News. She primarily covers Dorchester and the surrounding neighborhoods.
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Call to Freedom raising awareness during National Human Trafficking Prevention Month – KELOLAND.com
Posted: at 3:58 pm
SIOUX FALLS, S.D. (KELO) This month is National Human Trafficking Prevention Month, and a local organization is working to build awareness.
We want to just make sure that the community is aware that yes, human trafficking is happening right here in Sioux Falls, but also throughout our state, Call to Freedom community engagement coordinator Monica Rilling said.
Call to Freedom has events going on in January to build awareness of human trafficking and sexual exploitation.
It is our, actually the National Human Trafficking Awareness Day, so this coming Tuesday, January 11, were just asking the community to build more awareness by wearing blue, so Im wearing my blue t-shirt today, and then putting a red X on your hand just to bring that awareness, Rilling said.
Call to Freedom associate director Michelle Treasure says their referrals have increased.
Last year in June of 2021, we had already met the the number of referrals that we had seen in the entire year of 2020, so now going into 2022, were not, unfortunately, expecting anything less. The number of referrals that are coming in are very high currently. I would say that were probably seeing around five to eight referrals a week, she said.
Their services can help victims of sex and labor trafficking as well as people who have suffered sexual exploitation or assault.
We just get to know those people. We get to know their story. What do they need? What are some of the goals that they have for their lives? Treasure said.
Call to Freedom also helps with housing, transportation and counseling. The organization says it is important for people to be on the lookout for signs of human trafficking.
Some of those red flags are going to be, you know, no eye contact. They may not be able to speak for themselves. The person thats with them might be talking for them. Their speech might sound very scriptive or robotic, Treasure said.
She also says to look for signs of physical abuse.
I think human trafficking has been going on a for a very very long time, Treasure said. I think now it has a name, and people know what it is and that exposure is out there because of the education and prevention that some of the organizations like Call to Freedom is doing out in the community.
Call to Freedom is opening a new facility in Sioux Falls in April to replace its current one.
Below is a flyer with the events Call to Freedom is hosting this month. You can also go to their Facebook page.
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As with Jesus, work for justice and freedom begins with baptism – CatholicPhilly.com
Posted: at 3:58 pm
Msgr. Joseph Prior
By Msgr. Joseph Prior Posted January 7, 2022
(See the readings for the Baptism of Our Lord, Jan. 9)
He will baptize you with the Holy Spirit and fire, the Baptist says at the end of his reply to those asking if he were the Christ. He emphatically had responded that he is not the Christ and that he is not even worthy to untie his sandals.
Johns baptism is, like his entire ministry, one that prepared for the coming of Jesus. Jesus is the one coming after me (John). When all is accomplished, he is the one who baptizes with the Holy Spirit and fire.
This Sunday we celebrate the Baptism of the Lord. The feast concludes our observation of Christmas and transitions us back to Ordinary Time. The feast recalls Jesus baptism in the desert as recounted in the Gospel passage, this year from St. Luke, as well as a reminder of our own baptism.
Jesus baptism is one that foreshadows ours. He undergoes the ritual washing as an example for us. The memory was vivid in the life of the early Church. Matthews account has John objecting when Jesus arrives for baptism saying: I need to be baptized by you, and you are coming to me? Jesus responds: Allow it for now, for thus it is fitting for us to fulfill all righteousness.
Reflecting on Jesus baptism, St. Maximus of Turin writes: Someone might ask, Why would a holy man (Jesus) desire baptism? Listen to the answer: Christ is baptized, not to be made holy by the water, but to make the water holy, and by his cleansing to purify the waters which he touched. For the consecration of Christ involves a more significant consecration of the water. For when the Savior is washed, all water for our baptism is made clean, purified at its source for the dispensing of baptismal grace to the people of future ages. Christ is the first to be baptized, then, so that Christians will follow after him in confidence.
After the Holy Spirit descends on Jesus in the form of a dove, the voice of the heavenly Father is heard: You are my beloved Son; with you I am well pleased. The words call to mind the Isaian passage used for the first reading in todays liturgy. Here is my servant whom I uphold, my chosen one with whom I am pleased, upon whom I have put my spirit.
The reading continues to describe the mission of Jesus. He will establish justice. He comes not with loud voice or strong arm but as a man gentle and meek. He is the one who is set as a covenant of the people, a light for the nations, who will open the eyes of the blind, to bring out prisoners from confinement, and from the dungeon, those who live in darkness.
The words also echo Jesus own understanding. In the beginning of the public ministry in Lukes Gospel, Jesus is in the synagogue and proclaims the Isaian passage: The Spirit of the Lord is upon me, because he has anointed me to bring glad tidings to the poor. He has sent me to proclaim liberty to the captives and recovery of sight to the blind, to let the oppressed go free, and to proclaim a year acceptable to the Lord (Luke 4:18-19).
After this he says: Today this scripture passage is fulfilled in your hearing (Luke 4:21). Baptism is linked to Jesus mission. The Father sends Jesus to establish justice and freedom. When all is accomplished, baptism will be the means by which this justice and freedom are experienced.
The two options for the second reading highlight this celebration. The first, from Acts of the Apostles, recalls Peters preaching in the house of Cornelius. In the reading he recalls Jesus mission beginning in Galilee after the baptism that John preached, how God anointed Jesus of Nazareth with the Holy Spirit and power. After Peters proclamation (but not included in this passage), Cornelius and his household all were baptized.
The second choice comes from the Letter of Titus. The reading reflects the cleansing nature of baptism. It is washing away of sin so that the Holy Spirit might be given. He writes: When the kindness and generous love of God our savior appeared, not because of any righteous deeds we had done but because of his mercy, he saved us through the bath of rebirth and renewal by the Holy Spirit, whom he richly poured out on us through Jesus our savior, so that we might be justified by his grace and become heirs in hope of eternal life.
The celebration of Jesus baptism reminds us of the great gift of grace shared with us in baptism. His baptism points to our baptism whereby we are washed clean, filled with the Holy Spirit and fortified to live the life of love, now and for eternity.
***
Msgr.Joseph Prior is pastor of Our Lady of Grace Parish, Penndel, and a former professor of Sacred Scripture and rector of St. Charles Borromeo Seminary.
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Jan. 6 vigil: We cannot abandon the ideals of freedom – Deseret News
Posted: at 3:58 pm
A disabled veteran sat in the front row and listened intently as an audience composed of people from all walks of life gathered Thursday evening to remember the attack that happened a year ago at the United States Capitol.
Utah civic leaders and political candidates addressed the audience at Wallace F. Bennett Federal Building in downtown Salt Lake City in what they called an effort to protect democracy and unite a nation divided. The candlelight vigil was held on the first anniversary of supporters of then-President Donald Trump storming the Capitol in Washington in an effort to prevent the certification of Joe Biden's victory in the 2020 presidential election.
Independent U.S. Senate candidate Evan McMullin emphasized the importance of keeping democracy sound and maintaining the public's right to vote alive by speaking out against insurgencies like the one on Jan. 6, 2021.
"Some mistake the Jan. 6 insurrection as a one-time betrayal of our democracy, but it was much more. It was a predictable escalation of the American anti-democracy movement," McMullin said.
McMullin was joined in his sentiments by Republican 4th District congressional candidate Jake Hunsaker, who said what happened that day caused him to pursue a run for public office.
"I sat like many of you in disbelief that day in front of the television, as I watched the unfolding of the events in Washington, D.C.," Hunsaker recalled.
Hunsaker spoke about growing up on a farm in Ogden and being one of 11 children. He told what he was taught about what it means to be called a "real man."
"I believe that a real man prioritizes peace over violence," Hunsaker said. "It is cheap to engage in violence. It is cheap to think that the only way to effect change in this democracy is to take weapons to the heart of our nation's capital and to force your ideas and untruths on others. It takes a real man to understand that in this country, we effect change through peaceful means."
The vigil, titled "We The People" and promoted as a day of remembrance and action, was organized by DemCast USA, 1Utah Project, Alliance for a Better Utah and Salt Lake Indivisible. Former 2nd District congressional candidate Kael Weston also spoke.
Utah activist Darlene McDonald concluded the evening with a heartfelt message speaking on behalf of those voices who were silenced in the beginning, and whose voices were nearly silenced once again one year ago. She spoke of her ancestors, many of whom came to America from a slave trading post in Ghana called Cape Coast Castle, "chained to a tribesman in the belly of a ship across the Atlantic." She spoke about the dream many of her ancestors had to be numbered among those in the statement, "All men are created equal."
McDonald expressed the concern that she shares with so many others, that incidents like Jan. 6, 2021, will once again threaten the ideals that America was founded on and continues to strive for.
"When we read the Declaration of Independence, many of us get hung up and emotional when we remember Dr. (Martin Luther) King reminding us that we hold these truths to be self-evident, that all men are created equal," McDonald said in her speech.
She reiterated what it means to her and so many others to be an American, and why she feels so strongly to speak out against attacks like these.
"We are not here because we hate America; we are here because we are Americans," she said. "We are not here because we want America to fail; we are here because we want America to live up to its promises. We are not here as blue America and red America; we are here as the United States of America. And united we stand because divided we will fall. We cannot abandon the ideals of freedom."
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Steve King: The freedom of want is still a dream – Canton Repository
Posted: at 3:58 pm
Steve King| Suburbanite correspondent
It was 79 years ago Thursday, on Jan. 6, 1941, that President Franklin Roosevelt delivered his famous Four Freedoms speech to Congress.
It was the main theme the overriding and the only theme, really of his 1941 State of the Union speech.
In future days, which we seek to make secure, we look forward to a world founded upon four essential freedoms, FDR said. As he saw and described them:
The first is freedom of speech and expression everywhere in the world.
The second is freedom of every person to worship God in his own way everywhere in the world.
The third is freedom of want which, translated into world terms, means economic understandings which will secure to every nation a healthy peacetime life for its inhabitants everywhere in the world.
The fourth is freedom from fear which, translated into world terms, means a worldwide reduction of armaments to such a point and in such a thorough fashion that no nation will be in position to commit an act of physical aggression against any neighbor anywhere in the world.
Then FDR added, That is no vision of a distant millennium. It is a definite basis for a kind of world attainable in our own time and generation.
At the same time, Hitler was waging war on Europe and Japan was doing the same in the Pacific, and then almost exactly 11 months afterward, the Japanese attacked Pearl Harbor to drag FDR and the United States, which had been staunchly isolationist, into World War II.
But though FDRs words were swallowed up then, they survived the war and in 1948, the United Nations used the Four Freedoms as its guideline in the Universal Declaration of Human Rights it adopted.
Its the third freedom the freedom of want that is of particular interest, at least to me, as it applies to hunger, especially children. I think hunger is the biggest need of the four freedoms. You cant live if theres not enough to eat.
I have mentioned on a number of occasions in this space that I work a side job as a clerk at a convenient store. It is a great study in human behavior, most times in a positive fashion that warms your heart and soul, but still too many times that make you grit your teeth, bite your tongue and shake your head in disgust.
The store is located in a generally well-to-do city of 60,000 people situated near a much larger city. As with any big city, there are areas of economic difficulties within, and the biggest one in this particular city sets just four miles from the store.
Customers think nothing of dropping $100, and even $200 and more, on cigarettes, beer and lottery tickets. To each their own, and this is not a general diatribe against those expenditures, but only in the sense that that money could do so much to feed the hungry kids just down the road.
More specifically, if just 10 percent of the sales of the aforementioned items in any convenience store in the area, including ours, were to go instead to the local foodbank, it would fill a lot of empty stomachs.
That those people would, in my opinion, never consider taking that money and donating it, let alone actually doing it, is numbingly disappointing and disheartening.
All these years later, those needs and those resulting emotions persist.
Franklin Roosevelt would be saddened.
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Singapore Airlines Adds New Fifth Freedom Route In Europe – Live and Let’s Fly
Posted: at 3:58 pm
Singapore Airlines will launch 3x weekly flights between two great European cities, as it prepares to restart its service to Milan (MXP) and add a Fifth Freedom tag flight to Barcelona (BCN).
With modern, more fuel efficient jetliners, we have seen fewer Fifth Freedom flights, which are flights in which an airline from one country operates flights between two other countries (as part of its connecting service to its home country). For example, Singapore Airlines operates service from New York to Singapore via Frankfurt and sells tickets between New York (JFK) and Frankfurt (FRA) on a stand-alone basis. This is known as a Fifth Freedom flight.
The new Fifth Freedom service between Milan and Barcelona will launch on January 17, 2022 and operate three times weekly (Monday, Wednesday, Friday) using an Airbus A350-900:
(I recently reviewed Singanpores A350-900 longhaul aircraft here)
> Read More: Singapore Airlines A350-900 Review BKK SIN + SIN LAX
The pandemic has also greatly reduced intercontinental flights schedules, but that could actually result in more Fifth Freedom flights going forward. In this case, Singapore likely did not see the commercial viability of operating flights to both Milan and Barcelona, but this arrangement allows it to serve both cities, even if travelers in Barcelona have to make an extra stop enroute.
Generally, these flights are full service, though at 1 hour, 25 minutes service may not be as extensive as you might expect on a one hour flight intra-Asia.
Theoretically, this 448-mile flight can be booked with the following programs on a one-way basis:
But I say theoretically because Singapore Airlines has traditionally been quite stingy in opening award space on its own flights to its Star Alliance partners and thus far, I only see the award space available through Singapores own KrisFlyer program.
Paid fares are about double of Spanish budget carrier Vueling on the same route, but still cheap enough: $122 one-way in economy class. Business class tickets are about $331 each way.
Singapore Airlines is launching a new Fifth Freedom flight between Milan and Barcelona. The service begins on January 17th, operates 3x weekly, and tickets are now sale.
Will you take this new Singapore Airlines Fifth Freedom flight?
(H/T: Travel With Massi)
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