Monthly Archives: May 2021

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Markets are beset by volatility, with unpredictable swings making recent sessions something of a roller coaster. The main indexes were falling sharply at the end of last week, but Fridays release of economic data showing strong manufacturing activity provided a boost that pared back the market losses somewhat. The recent earnings season also gave reason for optimism the S&P listed companies, collectively, reported 46% year-over-year earnings gains in Q1, compared to the 20% expected. Goldman Sachs strategist David Kostin sees the generally positive macro data providing support for equities in an uncertain market environment. The combination of global reopening, elevated consumer savings, and strong corporate operating leverage will drive sharp recoveries in both economic and earnings growth... U.S. equities will continue to appreciate, albeit at a slower pace than has characterized the past 12 months equities will remain attractive relative to cash and bonds, Kostin noted. Taking this into consideration, our attention turned to three stocks that Goldman Sachs thinks have outsized growth prospects, with the firms analysts forecasting over 100% upside potential for each. Using TipRanks database, we found out that the rest of the Street is also on board, as each boasts a Strong Buy consensus rating. Rain Therapeutics (RAIN) Well start with a newly public biopharmaceutical company Rain Therapeutics. The company is developing a tumor-agnostic treatment strategy that selects patients based on the underlying genetics rather than the histology of the disease. Rain has two drug candidates in the pipeline, RAIN-32, which is undergoing several clinical trials, and RAD52, which is still in preclinical trial. Taking a closer look at the pipeline, we find that RAIN-32, an MDM2 inhibitor called milademetan, has a Phase 3 trial for WD/DD liposarcoma scheduled to begin in the second half of this year. At the same time, a Phase 2 trial, an MDM2 basket study, is also scheduled for 2H21. Beyond the WD/DD Phase 3 and the Phase 2 Basket study, the company is also looking to initiate another Phase 2 study in intimal sarcoma by early 2022. RAD52, the companys second pipeline candidate, is a novel approach to the treatment of breast, prostate, pancreatic, and ovarian cancers. The drug is still in early research phases, but lead candidate selection for clinical studies is set to begin sometime next year. As mentioned above, Rain is a newly public company; it held its IPO in April of this year. The company put 7,352,941 shares on the American public markets, at $17 each. The IPO raised about $125 million in gross proceeds. Opening coverage of this stock for Goldman Sachs, analyst Graig Suvannavejh writes: While were optimistic on RAIN-32s prospects in LPS, the revenue opportunity appears modest, as we project peak risk-unadj./adj. sales of $612mn/$428mn (assumes 70% POS), given just c.3K in US annual incidence. That said, our enthusiasm for RAIN also rests on RAIN-32s potential beyond LPS, including in intimal sarcoma (an ultra orphan cancer), and also MDM2-amplified solid tumors, which we see as a substantial market opportunity. Across these three, we project $2.2bn/$859mn in peak yr risk unadj./adj. sales in the US/EU5, with other future indications for RAIN-32 (trials to start in 2022) and also a preclinical RAD52 program (a synthetic lethality play) representing upside potential to our forecasts. In line with his bullish stance, Suvannavejh rates RAIN a Buy, and his $56 price target implies room for a stunning 252% upside potential in the next 12 months. (To watch Suvannavejhs track record, click here) Turning now to the rest of the Street, other analysts echo Suvannavejh's sentiment. As only Buy recommendations have been published in the last three months, RAIN earns a Strong Buy analyst consensus. With the average price target clocking in at $33.75, shares could soar 112% from current levels. (See RAIN stock analysis on TipRanks) Relmada Therapeutics (RLMD) The next stock on Goldman Sachs's radar, Relmada Therapeutics, is a clinical-stage pharmaceutical firm, which focuses on issues of the central nervous system. REL-1017, the companys prime pipeline candidate, is a novel NMDA receptor channel blocker under development as a treatment for major depressive disorder. Mental health is a major segment of the pharmaceutical industry, and the antidepressant piece of the mental health pie is expected to exceed $18.5 billion by 2027. Relmada started RELIANCE I, the first pivotal trial of REL-1017, in December of last year, testing the drug as an adjunctive treatment for major depression. By this past April, two additional studies, RELIANCE II and RELIANCE-OPS were underway. All three are now ongoing, and a fourth, Phase 1, study of REL-1017 as a monotherapy is set to begin in the first half of this year. Top-line data from the two pivotal studies is scheduled for release in 1H22. Goldman Sachs analyst Andrea Tan covers this stock, and she gives it a Buy rating along with a $78 price target that implies a 103% upside over the next 12 months. (To watch Tans track record, click here) We note a string of key events in 2021+ that could drive value inflection: (1) human abuse potential (HAP) study against positive control oxycodone in 2Q21 and ketamine in 2H21, where we see the market as pricing in too much risk of a negative outcome (see scenario analysis within); (2) topline data for monotherapy REL-1017 in 4Q21; and (3) topline pivotal data in adjunctive MDD (GSe peak sales of $2.5bn in 2033) in 1H22 with NDA submission to follow thereafter, all of which we are constructive on given the differentiated profile demonstrating rapid onset of action, enhanced efficacy, and good tolerability to-date, Tan opined. What does the rest of the Street have to say? 3 Buys and no Holds or Sells add up to a Strong Buy consensus rating. Given the $67.67 average price target, shares could climb 76% in the year ahead. (See RLMD stock analysis at TipRanks) Agiliti (AGTI) Well close out our look at high-potential Goldman picks with Agiliti. The company is a provider of medical equipment, offering hospitals and health systems a range of bariatrics, beds, therapy mattresses, fall prevention devices, ventilators, breast pumps, patient monitors, medical-grade adjustable chairs, and surgical equipment along with the technical support, clinical engineering, and on-site management to properly use, maintain, and adjust the myriad devices. By the numbers, Agiliti boasts over 90 service centers across the lower 48 states, supporting more than 800,000 pieces of medical equipment in over 7,000 acute care hospitals and alternate medical sites. On April 23 of this year, Agility debuted its stock on the NYSE in an IPO that was initially priced at $14. The company put over 26.3 million shares on the market, and raised approximately $431.5 million in gross proceeds in the first day of the IPO. Last week, Agiliti released its first quarterly financial report as a public company. The top line revenue, at $235 million, was 31% higher than the year-ago Q1. Net income was $9.6 million, up a strong $22.2 million from last years Q1 net loss, and EPS was 9 cents per share. Looking at the companys forward path, Goldman Sachs analyst Amit Hazan noted, While not reflected in the 1Q close balance sheet, management provided visibility to post-IPO leverage of approximately 3.3x on a pro-forma basis. While somewhat constrained from a managerial standpoint given demands from Northfield, management expects both the financial and managerial flexibility to pursue opportunistic M&A by later this year. Hazan summed up, "We view AGTIs end-to-end service model as differentiated and ideally suited in todays Hospital operating environment; we see current valuation as an attractive entry point... To this end, Hazan gives AGTI shares a Buy rating, and his $43 price target implies a 151% upside for the coming year. (To watch Hazans track record, click here) In its first few weeks on the public markets, AGTI shares have picked up 9 reviews, which include 8 Buys and just 1 Hold. The stock is selling for $17.12 and the $21.39 average price target suggests it has room for ~25% one-year upside potential. (See AGTI stock analysis on TipRanks) To find good ideas for stocks trading at attractive valuations, visit TipRanks Best Stocks to Buy, a newly launched tool that unites all of TipRanks equity insights. Disclaimer: The opinions expressed in this article are solely those of the featured analysts. The content is intended to be used for informational purposes only. It is very important to do your own analysis before making any investment.

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Google CEO: The digital divide is 'easier to bridge than most people think' - Yahoo Finance

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Markets are beset by volatility, with unpredictable swings making recent sessions something of a roller coaster. The main indexes were falling sharply at the end of last week, but Fridays release of economic data showing strong manufacturing activity provided a boost that pared back the market losses somewhat. The recent earnings season also gave reason for optimism the S&P listed companies, collectively, reported 46% year-over-year earnings gains in Q1, compared to the 20% expected. Goldman Sachs strategist David Kostin sees the generally positive macro data providing support for equities in an uncertain market environment. The combination of global reopening, elevated consumer savings, and strong corporate operating leverage will drive sharp recoveries in both economic and earnings growth... U.S. equities will continue to appreciate, albeit at a slower pace than has characterized the past 12 months equities will remain attractive relative to cash and bonds, Kostin noted. Taking this into consideration, our attention turned to three stocks that Goldman Sachs thinks have outsized growth prospects, with the firms analysts forecasting over 100% upside potential for each. Using TipRanks database, we found out that the rest of the Street is also on board, as each boasts a Strong Buy consensus rating. Rain Therapeutics (RAIN) Well start with a newly public biopharmaceutical company Rain Therapeutics. The company is developing a tumor-agnostic treatment strategy that selects patients based on the underlying genetics rather than the histology of the disease. Rain has two drug candidates in the pipeline, RAIN-32, which is undergoing several clinical trials, and RAD52, which is still in preclinical trial. Taking a closer look at the pipeline, we find that RAIN-32, an MDM2 inhibitor called milademetan, has a Phase 3 trial for WD/DD liposarcoma scheduled to begin in the second half of this year. At the same time, a Phase 2 trial, an MDM2 basket study, is also scheduled for 2H21. Beyond the WD/DD Phase 3 and the Phase 2 Basket study, the company is also looking to initiate another Phase 2 study in intimal sarcoma by early 2022. RAD52, the companys second pipeline candidate, is a novel approach to the treatment of breast, prostate, pancreatic, and ovarian cancers. The drug is still in early research phases, but lead candidate selection for clinical studies is set to begin sometime next year. As mentioned above, Rain is a newly public company; it held its IPO in April of this year. The company put 7,352,941 shares on the American public markets, at $17 each. The IPO raised about $125 million in gross proceeds. Opening coverage of this stock for Goldman Sachs, analyst Graig Suvannavejh writes: While were optimistic on RAIN-32s prospects in LPS, the revenue opportunity appears modest, as we project peak risk-unadj./adj. sales of $612mn/$428mn (assumes 70% POS), given just c.3K in US annual incidence. That said, our enthusiasm for RAIN also rests on RAIN-32s potential beyond LPS, including in intimal sarcoma (an ultra orphan cancer), and also MDM2-amplified solid tumors, which we see as a substantial market opportunity. Across these three, we project $2.2bn/$859mn in peak yr risk unadj./adj. sales in the US/EU5, with other future indications for RAIN-32 (trials to start in 2022) and also a preclinical RAD52 program (a synthetic lethality play) representing upside potential to our forecasts. In line with his bullish stance, Suvannavejh rates RAIN a Buy, and his $56 price target implies room for a stunning 252% upside potential in the next 12 months. (To watch Suvannavejhs track record, click here) Turning now to the rest of the Street, other analysts echo Suvannavejh's sentiment. As only Buy recommendations have been published in the last three months, RAIN earns a Strong Buy analyst consensus. With the average price target clocking in at $33.75, shares could soar 112% from current levels. (See RAIN stock analysis on TipRanks) Relmada Therapeutics (RLMD) The next stock on Goldman Sachs's radar, Relmada Therapeutics, is a clinical-stage pharmaceutical firm, which focuses on issues of the central nervous system. REL-1017, the companys prime pipeline candidate, is a novel NMDA receptor channel blocker under development as a treatment for major depressive disorder. Mental health is a major segment of the pharmaceutical industry, and the antidepressant piece of the mental health pie is expected to exceed $18.5 billion by 2027. Relmada started RELIANCE I, the first pivotal trial of REL-1017, in December of last year, testing the drug as an adjunctive treatment for major depression. By this past April, two additional studies, RELIANCE II and RELIANCE-OPS were underway. All three are now ongoing, and a fourth, Phase 1, study of REL-1017 as a monotherapy is set to begin in the first half of this year. Top-line data from the two pivotal studies is scheduled for release in 1H22. Goldman Sachs analyst Andrea Tan covers this stock, and she gives it a Buy rating along with a $78 price target that implies a 103% upside over the next 12 months. (To watch Tans track record, click here) We note a string of key events in 2021+ that could drive value inflection: (1) human abuse potential (HAP) study against positive control oxycodone in 2Q21 and ketamine in 2H21, where we see the market as pricing in too much risk of a negative outcome (see scenario analysis within); (2) topline data for monotherapy REL-1017 in 4Q21; and (3) topline pivotal data in adjunctive MDD (GSe peak sales of $2.5bn in 2033) in 1H22 with NDA submission to follow thereafter, all of which we are constructive on given the differentiated profile demonstrating rapid onset of action, enhanced efficacy, and good tolerability to-date, Tan opined. What does the rest of the Street have to say? 3 Buys and no Holds or Sells add up to a Strong Buy consensus rating. Given the $67.67 average price target, shares could climb 76% in the year ahead. (See RLMD stock analysis at TipRanks) Agiliti (AGTI) Well close out our look at high-potential Goldman picks with Agiliti. The company is a provider of medical equipment, offering hospitals and health systems a range of bariatrics, beds, therapy mattresses, fall prevention devices, ventilators, breast pumps, patient monitors, medical-grade adjustable chairs, and surgical equipment along with the technical support, clinical engineering, and on-site management to properly use, maintain, and adjust the myriad devices. By the numbers, Agiliti boasts over 90 service centers across the lower 48 states, supporting more than 800,000 pieces of medical equipment in over 7,000 acute care hospitals and alternate medical sites. On April 23 of this year, Agility debuted its stock on the NYSE in an IPO that was initially priced at $14. The company put over 26.3 million shares on the market, and raised approximately $431.5 million in gross proceeds in the first day of the IPO. Last week, Agiliti released its first quarterly financial report as a public company. The top line revenue, at $235 million, was 31% higher than the year-ago Q1. Net income was $9.6 million, up a strong $22.2 million from last years Q1 net loss, and EPS was 9 cents per share. Looking at the companys forward path, Goldman Sachs analyst Amit Hazan noted, While not reflected in the 1Q close balance sheet, management provided visibility to post-IPO leverage of approximately 3.3x on a pro-forma basis. While somewhat constrained from a managerial standpoint given demands from Northfield, management expects both the financial and managerial flexibility to pursue opportunistic M&A by later this year. Hazan summed up, "We view AGTIs end-to-end service model as differentiated and ideally suited in todays Hospital operating environment; we see current valuation as an attractive entry point... To this end, Hazan gives AGTI shares a Buy rating, and his $43 price target implies a 151% upside for the coming year. (To watch Hazans track record, click here) In its first few weeks on the public markets, AGTI shares have picked up 9 reviews, which include 8 Buys and just 1 Hold. The stock is selling for $17.12 and the $21.39 average price target suggests it has room for ~25% one-year upside potential. (See AGTI stock analysis on TipRanks) To find good ideas for stocks trading at attractive valuations, visit TipRanks Best Stocks to Buy, a newly launched tool that unites all of TipRanks equity insights. Disclaimer: The opinions expressed in this article are solely those of the featured analysts. The content is intended to be used for informational purposes only. It is very important to do your own analysis before making any investment.

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RISE Education Cayman's (NASDAQ:REDU) Stock Price Has Reduced 77% In The Past Three Years - Yahoo Finance

The NBA on Monday announced the creation of NBA Africa, where it will hold standalone business operations and has lured many NBA figures as investors in the venture.

The NBA has business relationships in other continents, so extending it to Africa where its relationship began in 1993 with a trip to the continent spearheaded by late commissioner David Stern seems like a logical move.

Some of its notable NBA investors include Grant Hill, Dikembe Mutombo, Junior Bridgeman, Joakim Noah and Luol Deng.

NBA commissioner Adam Silver, in an early morning news conference, estimated the enterprise value for NBA Africa is worth nearly $1 billion.

Africa is a growing market globally, and the NBAs relationship has grown in recent years, illustrated by the new 12-team Basketball Africa League. Victor Williams, NBA Africa CEO, believes basketball will become a main footprint in Africa within the next 10 years.

In order to reach that milestone, we've developed a comprehensive growth plan that will greatly accelerate the development of Africa's basketball ecosystem, deepen our fan engagement efforts, advanced social responsibility, and drive economic growth, Williams said.

The future of Africa is bright. And we will continue to use the game to shine a spotlight on Africa's capacity to be a global leader.

NBA commissioner Adam Silver, in an early morning news conference, estimated the enterprise value for NBA Africa is worth nearly $1 billion. (Cyril Ndegeya/Xinhua via Getty Images)

Silver and Deputy Commissioner Mark Tatum will serve, among others, on the NBA Africa board of directors.

African investors include Nigerian Babatunde "Tunde" Folawiyo, Chairman and CEO of Yinka Folawiyo Group and Helios Fairfax Partners Corporation, led by Nigerian Tope Lawani, co-CEO of HFP and co-founder and managing partner of Helios Investment Partners.

The groups wide range of experiences in the business world should help NBA Africas growth as it aims to establish content, gain media rights and build corporate sponsorships very similar to the NBAs relationship with China.

Lawani recalls watching the 1994 NBA Finals on his small television when Nigerian-born Hakeem Olajuwon led the Houston Rockets to the first of two straight championships.

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I was proud to be Nigerian, proud to be African, Lawani said.

Silver pointed out the 55 NBA players who are from Africa or have one or both parents who are African. One player who was on that trip with commissioner Stern in 1993 was Mutombo, a native of Congo.

Mutombo has been very invested in hospitals in Congo, and met former South African president Nelson Mandela on that trip.

Africa is one of the youngest population in the world. And Africa youth have just need the opportunity and the support to achieve great things, Mutombo said. The new NBA Africa is that transformative next step, to do just that: giving more African youth the same opportunity that I had many years ago.

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NBA announces formation of NBA Africa as the sport expands on the continent - Yahoo Sports

One of the nation's leading epidemiologists has called on the government to do more to convince young Australians to take the Covid-19 vaccine when it becomes available to them.

UNSW Professor Mary-Louise McLaws, who is a World Health Organisation advisor, said it was vital more was done to convince people aged between 20 and 30 to come forward for the vaccine amid waning public support for inoculation after the emergence of rare blood clotting complications with the AstraZeneca jab.

"We should be talking about how do we get the 20 and 30-year-olds vaccinated because they represent up to 40 per cent of all cases last year," she told ABC Breakfast on Monday.

She said the age group needs to be motivated to take the jab, and should be told "they are heroes" by doing so.

"They are going to save us and that is true," Prof McLaws said.

She said it was vital fear surrounding the vaccine was dispelled and mixed-messaging around their safety needed to stop.

"Every vaccine does have some risk, but it is so small compared to the risk for the 20-39 -year-olds acquiring COVID-19 and spreading it," Prof McLaws said.

Mary-Louise McLaws says young Australian adults will play a key role in how successful the vaccine rollout is. Source: Getty

"So we need to tell them that we are forever grateful for what they going to do for the country."

Experts have continuously warned Australia will only be able to open its borders once herd immunity is achieved.

According to a recent paper published by UNSW epidemiologist Professor Raina MacIntyre, 75 per cent of a population would need to be vaccinated for a vaccine with 80 per cent efficacy to achieve herd immunity.

An entire population would need to be vaccinated if efficacy is as low as 60 per cent.

Recent research has indicated the AstraZeneca is less effective than the Pfizer and Moderna jabs.

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Recent Public Health England research found the Pfizer jab was 88 per cent effective at stopping symptomatic disease from the now dominant Indian strain in the UK, while the AstraZeneca was much lower at 60 per cent.

The Australian Technical Advisory Group on Immunisation (ATAGI) recommends the Pfizer jab over AstraZeneca jab for adults aged under 50 years due to the rare blood clotting side-effects.

Yet Australia's vaccine rollout has been plagued by complications and has fallen significantly behind schedule.

About 3.6 million doses of coronavirus vaccines have so far been administered, through a mix of AstraZeneca and Pfizer jabs well behind the targets previously set.

However the government is now promising two million doses of Pfizer will arrive in Australia each week from the start of October.

The Department of Health had previously promised all adults will have been offered a jab by the same month.

The latest pledge could see every Australian who wants protection from COVID-19 could be fully immunised by the end of this year.

Physician Dr Norman Swan, the face of the ABC's coronavirus coverage, said the government was "dreaming". He predicted it will be well into 2022 when all adults will have been offered a vaccine.

Finance Minister Simon Birmingham said the significantly increased doses was the government's hope but stopped short of making a firm commitment.

"There have been many uncertainties in the vaccine rollout to date and we need to continue to be honest about the fact we can't control every aspect of global supply," he said.

"We can't control whether there are unexpected impacts in relation to health or other factors or advice that impact the vaccine rollout."

Do you have a story tip? Email: newsroomau@yahoonews.com

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The surprising age group that will save Australia from Covid-19 - Yahoo News Australia