Monthly Archives: May 2021

Objectives:Although causality remains to be established, targeting dysbiosis of the intestinal microbiota by faecal microbiota transplantation (FMT) has been proposed as a novel treatment for inflammatory diseases. In this exploratory, proof-of-concept study, we evaluated the safety and efficacy of FMT in psoriatic arthritis (PsA).

Methods:In this double-blind, parallel-group, placebo-controlled, superiority trial, we randomly allocated (1:1) adults with active peripheral PsA (3 swollen joints) despite ongoing treatment with methotrexate to one gastroscopic-guided FMT or sham transplantation into the duodenum. Safety was monitored throughout the trial. The primary efficacy endpoint was the proportion of participants experiencing treatment failure (ie, needing treatment intensification) through 26 weeks. Key secondary endpoints were change in Health Assessment Questionnaire Disability Index (HAQ-DI) and American College of Rheumatology (ACR20) response at week 26.

Results:Of 97 screened, 31 (32%) underwent randomisation (15 allocated to FMT) and 30 (97%) completed the 26-week clinical evaluation. No serious adverse events were observed. Treatment failure occurred more frequently in the FMT group than in the sham group (9 (60%) vs 3 (19%); risk ratio, 3.20; 95% CI 1.06 to 9.62; p=0.018). Improvement in HAQ-DI differed between groups (0.07 vs 0.30) by 0.23 points (95% CI 0.02 to 0.44; p=0.031) in favour of sham. There was no difference in the proportion of ACR20 responders between groups (7 of 15 (47%) vs 8 of 16 (50%)).

Conclusions:In this first preliminary, interventional randomised controlled trial of FMT in immune-mediated arthritis, we did not observe any serious adverse events. Overall, FMT appeared to be inferior to sham in treating active peripheral PsA.

Trial registration number:NCT03058900.

Keywords:arthritis; inflammation; psoriatic; therapeutics.

Read more from the original source:
Safety and efficacy of faecal microbiota transplantation for active peripheral psoriatic arthritis: an exploratory randomised placebo-controlled trial...

I have psoriasis. Ive had it since I was in elementary school, and I have finally decided Ive had enough. I recently started a new injectable biologic to control it. While I was digging for good news about my skin, I found a video of a guy discussing all the things he tried before turning to injectables. He started off discussing a psoriasis diet he had tried for several months.

It wasnt the diet that caught my attention.

It was the way he talked about it. He was visibly frustrated as he explained that the strict diet he was on actually did help his psoriasis. He saw marked improvement. But he couldnt stick to it long term because it was so all-consuming.

His basic sentiment was, It came to a point where I could do this diet to help my skin, or I could have all the other parts of the rest of my life. I chose a normal life. As a thin person, I am sure this felt like a big revelation to him.

As a fat person, I was like NO EFFING KIDDING.

Limiting your diet is an emotional roller coaster no matter what the reason, but when its motivated by diet cultures hatred for the way your body looks, its literally 24/7 hard. Its maintaining constant focus on the ways your body doesnt stack up to societys standards.

That SUCKS. Its soul-crushing. It hurts. Even when it works.

I know that I could stick to a very strict, very large calorie deficit and lose weight. I could prioritize a time-consuming, intense exercise regimen and change my body to some extent.

Theres a high likelihood that, for me, it would be disordered, motivated by self-loathing, and feel like total misery.

But it would work if you consider success to be shrinking my body into a more acceptable size and shape. Because its not technically impossible for me to become thinner, many people believe that I should be on a perpetual diet every single day of my life until I attain a level of thinness that makes me sexually acceptable to the men who dictate our beauty standards.

Story continues

It doesnt matter that its unreasonably hard for some people. That truth is constantly brushed off as an excuse or laziness. Nobody wants to hear that every body actually doesnt respond the same way to every diet, and that what worked for them might not work for me. A lot of people dont allow a fat person the space and respect to say, Dieting, for me, gets to a point where it controls my life, and I get to choose between that and my own happiness and mental health. We dont get to prioritize our mental health and happiness without judgment.

Fat people are supposed to be constantly in progress until we are thinand then?

We are supposed to spend the rest of our lives working to maintain that thinness.

And we are supposed to do this without any complaint, without any sympathy for how incredibly hard it is because we are supposed to want to be thin more than we want to enjoy food along with everyone else, and relax into our bodies as they are.

Its interesting to me because there actually was one time in my life when people seemed to feel for me when I was on a very restricted diet. I wasnt thin. I was pregnant. In my third trimester with my last baby, I found out I had gestational diabetes. Luckily, I didnt have any trouble controlling my blood sugars, and we both turned out no worse for the wear.

But I had to navigate the holiday season without a single treat, with very few carbs, carefully measuring my portions and ensuring that I created a safe environment for my growing baby.

It is the one time in my life that I did not struggle one little bit. My health and my babys health depended on my restricted diet. It was a no-brainer that I would do what I needed to do in order to keep us both safe.

Its also the one time when I was inundated with compassion. People wanted to tell me that they understood how tough it was. They seemed to fully understand how overwhelmed I must be asking about ingredients, tracking everything I ate, testing my blood, checking my babys weight via weekly ultrasounds. A lot of people even promised to bring my favorite sweet treats to the hospital after my baby was born, realizing how comforting and yummy that would be for me.

The fact that gestational diabetes was largely out of my control seemed to be my golden ticket to understanding.

My higher weight, despite much scientific evidence to the contrary, is still largely regarded as something that is completely within my control, and therefore, I am not entitled to be okay with it.

Why can people muster up sympathy for people who have to limit their diets due to illnesses, but they expect fat people in good health (we do exist!) to be on a perpetual diet, never ever just eating whats available, letting their body exist as it is? Why is it still such a no-go to just accept that youre fat and let that be the case, even if only for a season?

I fought my body for years. For most of my teens and twenties and even a couple years of my very early thirties, I was always on a diet. Every time I ate a meal or treat without knowing how many calories, carbs or fat was in it, I felt a nagging guilt that I was cheating on my diet. Despite my best efforts, I never quite changed my body enough to become acceptable. Not even close.

And then, I decided to see what it felt like to try to make peace with my body instead of constantly fighting it. I didnt gain weight as I always thought I would. Sometimes, I even lose weight without trying. My weight fluctuates naturally almost as much as it did when I was frequently actively dieting.

I still diet once in a while. I have learned to make peace with my body, but I live in this thin-obsessed culture and sometimes I still find myself itching to see if I can get a little closer to thin.

Because dieting isnt all tough. The high of watching the weight come off is enough to keep me going sometimes. When its working and your body is shrinking, dieting can feel good. (But it can also quickly evolve into a really harmful pattern of disordered eating if youre susceptible to that.) Inching closer to societys idea of what you should look like feels hopeful sometimes.

But, for me, theres something really draining about trying to convince myself to frame the experience as a permanent change of lifestyle, when it almost always feels like an unsustainable way to live. Im not alone in that exhaustion.

https://www.instagram.com/p/COGvdHwBhwz/

Most fat people I have spoken to agree that its just really heavy to be so focused on the ways your body doesnt stack up to societys standards. Dieting can bring that to the forefront in ways that are really tough to handle for extended periods of time.

There is so much you dont know about a fat persons health, history and choices just by looking at them. If you know a fat person who seems to you to be letting themselves go or not caring about their health, mind your own business, and let them be. Mental health IS health, and we dont owe anyone a smaller body or an explanation as to why we arent killing ourselves to attain one.

See the original article on ScaryMommy.com

Go here to see the original:
Fat People Dont Have To Be On A Perpetual Diet - Yahoo Lifestyle

As the United States looks to combat vaccine hesitancy, at least one group is feeling even more confident in a vaccinebut not the COVID-19 shot: Patients with autoimmune rheumatic diseases (ARDs) had a higher rate of flu vaccinations during the pandemic, researchers discovered.

A total of 1,015 patients were interviewed. A greater proportion of patients received the flu shot during the pandemic (2020-21 season) than before (2019-20 season). Fewer than 1% of patients who got the shot reported disease flares.

In the pre-pandemic period, patients were more likely to say their rheumatologist did not recommend the shot compared to during the pandemic. During both flu seasons, other reasons patients skipped out on the shot included they didnt think it would have any benefit, they didnt feel it was safe, and other.

Another study analyzed the prevalence of and risk factors for venous thromboembolism (VTE) in patients with psoriasis and psoriatic arthritis (PsA). Final analysis included 2,433 patients, and there were 26 incident VTEs. The incident rate of the first VTE was 12 events per 10,000 patient-years. By age 80, 4.6% of patients had developed their first VTE. Factors independently correlated with VTE were older age, diabetes mellitus, and corticosteroid usage.

Finally, a study compared golimumab treatment retention among patients with rheumatoid arthritis (RA), axial spondyloarthritis (AxSpA), and PsA. Compared to patients with RA, those with AxSpA or PsA had higher rates of retention. Further, retention rates were higher when golimumab was a first-line treatment instead of third or later. Use as first-line biological therapy, having AxSpA or PsA (instead of RA), and concomitant methotrexate therapy were all correlated with increased golimumab retention, while steroid use reduced retention.

In Case You Missed It

Flu Shot Rates Increased During COVID-19 Pandemic among Patients with Autoimmune Rheumatic Diseases

Risk Factors for VTE in Patients with Psoriasis, Psoriatic Arthritis

Golimumab Treatment Retention Comparison: RA, AxSpA, and PsA

The rest is here:
Rheum Round-up: More Rheumatic Pts Got Flu Shot, VTE in PsA, and more - DocWire News

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Top Companies in the Global Psoriasis Therapeutics Market are Astellas Pharma Inc., AstraZeneca plc, Boehringer Ingelheim GmbH, F. Hofffmann-La Roche, GlaxoSmithKline plc, Merck & Co., Inc., Valeant Pharmaceuticals International, Inc., Biocon Limited, Eli Lilly and Company, G & W Laboratories Inc.

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TNF Inhibitors

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Topical

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Psoriasis Therapeutics Market 2021 Size, Status and Business Outlook Astellas Pharma Inc., AstraZeneca plc, Boehringer Ingelheim GmbH The Courier -...