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Monthly Archives: May 2021
TodayTix Announces Acquisition of Broadway Roulette – TicketNews
Posted: May 11, 2021 at 10:53 pm
TodayTix, theatre-focused ticket resale marketplace with ties to Broadway producers, has announced its acquisition of Broadway Roulette, a transaction which closed in April. The deal will leave Broadway Roulettes website intact, rather than folding it in to the TodayTix system directly.
According to the release announcing the acquisition, Broadway Roulette make[s] it fun and easy to see a Broadway show (or shows!) by removing the pain points of traditional ticket-buying. Consumers can enter a date, number of tickets, and several of their preferences regarding things they like and dont like, and the algorithm will pair them to tickets to a show that fits the bill ranging from $49-99 per seat, depending on cyustomer settings. Availaiblity reportedly includes sold out shows among its offerings, meaning the chance of a jackpot ticket for far below market price exists.
Our aim is to gamify the ticket-buying experience so that more people see more shows, more often, says Broadway Roulettes Elizabeth Durand Streisand. The system tracks user transaction history, and promises to never send them to the same show more than once.
Broadway Roulettes existing management team, which counts Megan OKeefe and Ali Sytsma as well as Durand Streisand, will be retained in the move to the TodayTix umbrella.
As a business were on a mission to find a seat for everyone, says TodayTix CEO Brian Fenty. That oftentime requires finding new audiences through innovative technologies and unique, but established, communities. Liz and her team have created a business that sits at the corssroads of both, leveraging complex (but fun!) technology with audiences who buy in non-traditional ways. Most importantly, though, the team was exceptional, and were always looking to bring new voices to our organization.
The announcement comes close on the heels of the announcement of the return of Broadway with full capacity crowds in September of 2021.
The full press release of the aquisition is included below:
May 6 New York We are pleased to share that TodayTix Group has acquired Broadway Roulette. As part of the deal, which closed in mid-April, Broadway Roulette will retain its own branding and website, while joining the larger suite of TodayTix Group products.
Founded in 2016, Broadway Roulettes mission is to make it fun and easy to see a Broadway show (or shows!) by removing the pain points of traditional ticket-buying. The platform allows customers to specify a date, number of tickets, and preferences about what they like (and dont) and Broadway Roulettes proprietary algorithm pairs them with tickets to a surprise show that matches their criteria, all for a low, flat price. (Currently, tickets range from $49-$99 depending on customer settings.) Every show on Broadway is in play, giving customers a chance to land jackpot tickets to sold-out shows, and Broadway Roulette tracks the shows a customer has seen and never sends them to the same show twice.
TodayTix CEO Brian Fenty said, As a business, were on a mission to find a seat for everyone. That oftentimes requires finding new audiences through innovative technologies and unique, but established, communities. Liz and her team have created a business that sits at the crossroads of both, leveraging complex (but fun!) technology with audiences who buy in non-traditional ways. Most importantly, though, the team was exceptional, and were always looking to bring new voices to our organization.
Our aim is to gamify the ticket-buying experience so that more people see more shows, more often, said Broadway Roulette cofounder Elizabeth Durand Streisand. We have always admired TodayTix as a driver of innovation in the theater industry. We believe that joining TodayTix Group will allow Broadway Roulette to expand our innovative model to other geographies and verticals, while strengthening our capabilities and reach within Broadway.
Broadway Roulettes team, including Elizabeth Durand Streisand, Megan OKeefe, and Ali Sytsma will move over with the company.
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"It Was Absurd": Bruins Forward Asham-Moroz Recounts Playing With U18 Gold Medalist – Discoverestevan.com – DiscoverEstevan.com
Posted: at 10:53 pm
The World Under-18 Hockey Championships have long been an introduction to the wider hockey world for young players looking to make their mark. Winnipeg native Conner Roulette used it that way this year, but two members of the Estevan Bruins needed no introduction to him.
Forwards Griffin Asham-Moroz and Brandon Ambrozik played for the Winnipeg Thrashers in 2018-19 alongside Roulette. While both were talented offensive players and put up big numbers, they both trailed behind Roulette, who put up an astonishing 88 points in 43 games.
"It was absolutely insane," Asham-Moroz recounted. "I would watch the kid go out and have a four-point night and come off looking like he wasn't even sweating. It was absurd, absolutely absurd."
It's hardly surprising Roulette went to the Seattle Thunderbirds of the WHL not long afterward, where he put up 39 points in 54 games as a rookie. After posting 12 points in 11 games this year for Seattle, he put up five points in seven games at the U18s. One of his goals was fit to give anyone who played AAA with him deja vu.
"In AAA, no one would be able to take the puck off of him, and if you did take the puck off him, he would come back two seconds later, lift your stick, take it back, and go the other way," Asham-Moroz said. "I heard there was one goal where the defenseman was coming out of his own zone and he (Roulette) took the puck from him and just ripped it. My mom said it was exactly like he would do in AAA."
Asham-Moroz is no stranger to having teammates appear on Sports Centre ("Jayden Davis, thank you very much," he said). But having a former teammate go in the first round of the NHL draft would be a new experience, and there's a chance Roulette makes that happen.
"Honestly, it's not going to surprise me," said Asham-Moroz. "He's a pretty big name in Winnipeg, lots of people know him. It's been no surprise in Winnipeg for a while that he's going to do something in hockey."
If Roulette does become a first rounder, it would be the second year in a row a Bruins player has seen an ex-teammate go in the first round after Braden Schneider, a former teammate of Kade McMillen, went in round one of the draft last year. For Asham-Moroz, it would mean a former linemate (albeit briefly) had made the jump.
"I played with him for the first six games of the year, then our coach switched it up," he said. "It was insane. I've never seen a kid who is two years younger than everyone else he's playing against but is somehow better than them. He's just somehow better. He has two years on me and he's so much more developed than I am. He's got a gift for hockey."
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The growth of Evolution Gaming Casino – PVP Live
Posted: at 10:53 pm
Evolution Gaming is a leading name in the live casino gaming industry. It is safe to accredit Evolution Gaming Casino with revolutionizing the casino gaming industry. Established in 2006, the company has exponentially grown and is the leading name in the industry. As of 2017, Evolution Gaming touched EUR 1.6bn capitalizations. It is owing to its immense popularity, many top casino gaming such as LeoVegas, ComeOn! Casino, Genting Casino, BetVictor, and Royal Panda have incorporated the Evolution Gaming software.
Evolution Gaming currently has more than 7000 employees. Jens von Bahr and Fredrik Ostenberg are the co-founders and Martin Carlesund is the CEO of Evolution Gaming. It is a public limited company, meaning that one can access detailed information about its revenue generation. In January 2019, the companys revenue touched 259 million and increased to a whopping 383.5 million, a nearly 48% jump in a single year.
As of 2019, Evolution Gaming broadcasted their live dealership games from Malta, Canada, and Latvia. Each of these gaming locations has many games in common, but not all. The studio in Canada hosts live Blackjack and Roulette but not Casino holdem.
The Evolution Gaming software supports a variety of games that include the following:
The tables set by Evolution Gaming have variants for almost every game. These tables majorly have two different variants:
In addition to this, a third and popular category is the table where the dealers talk to the players in the latters native language. Such a practice creates an environment of calmness as you have someone with whom you can have conversations in your native language.
The upper limit of the table wage varies based on factors, including the game, the jurisdiction, and the table. However, most tables permit you to play for as high as 5,000 for Blackjack and a more elevated amount for Roulette.
Apart from the ever-blooming growth of Evolution Gaming, its compatibility and ease in integration are the two main reasons behind it is widely accepted.
Evolution Gaming fits in with almost all software solutions. Most casinos that use Evolution Gaming also use software that is a virtual gaming casino from a different software provider.
As far as compatibility is concerned, the live dealer games hosted by Evolution Gaming can be live streamed and played from almost all devices, including laptops, tablets, smartphones, desktops, and television sets. iPad, iPad mini, and iPad Air of all generations, Android tablets from manufacturers Sony, Nexus, and Samsung, iPhones of all ages, and Android Smartphones from major manufacturers support live streaming and playing on Evolution Gaming Casino. Most all the devices and models that connect to the internet support Evolution Gaming.
Integrity and compatibility are the two main reasons why most live casino Playstations prefer utilizing Evolution Gaming Casino. Besides those, there are a set of advantages for players.
1. Bonus
Evolution Gaming Casino integrates with individual casinos giving them freedom over promotional structure and bonuses. Live casino bonuses, contests and cash giveaways attract a good number of players.
2. Instant Play
An instant play gives players ease of access. They must have Adobe Flash software installed on their devices. It will enable players to shift from one live game to another hassle-free.
3. Fair and just
Evolution Gaming Casinos are, without a doubt, fair and just. You can witness the entire game live. Evolution Gaming has had eCogra and TST audit its fairness in gameplay to build trust with its players. Players can see these audit reports by clicking on the seals below each casino supported by Evolution Gaming.
Evolution Gaming is regulated and licensed by the following bodies:
The following bodies have certified Evolution Gaming:
Evolution Gaming has some of the most outstanding gaming features for players, according to online casino 12bet. Here is a list of the few:
Evolution Gaming is famous for obvious reasons. It comes with several outstanding features, unlike most of its peers. It offers a variety of games and gaming options. Most renowned casino audits have given it excellent reviews. So go ahead and try your luck out!
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Best casinos to visit in the US – FTNnews.com – FTNnews.com
Posted: at 10:53 pm
If you are looking to spice up your vacation or have a perfect weekend getaway with a good dose of gambling, then your next casino trip should be to the United States of America.
If you are a resident of the land of opportunity, then it's all the better for you.
The United States houses the best casino destinations in the world. American states like Nevada, Mississippi, New Jersey, Connecticut, and several others feature top casinos that will give you pure gambling entertainment for your real money.
These gambling places offer a wide range of slot machines and table games like roulette, blackjack, and poker in a safe and attractive gambling environment.
Even when you get tired of gambling, you will find several attractions like shows, displays, spas, and shops at these resorts that will keep you entertained. Here are some of the best casinos to visit in the United States.
Bellagio Las Vegas Nevada
Bellagio is one of the most famous and best casinos in the world.
This casino's main attractions are elegant aesthetics, a slot pool with massive jackpots, and high-stakes poker.
The classy atmosphere at Bellagio makes it a happening place for society's creme de la creme.
Borgata Hotel Casino and Spa Atlantic City
The Borgata resort is the star attraction of Atlantic City when it comes to casino gambling.
The casino features over 3,000 gaming machines, attractive decor, and a modern spa.
Eat sumptuous and delicious food at restaurants like The Marketplace Eatery, The Angeline by Micheal Symon for great steaks, and Noodles of the world for the best-cooked noodles.
Wynn Las Vegas
You can only have your best Sin City weekend casino getaways at Wynn. This luxury resort offers players and tourists a great deal of fun in and out of the gambling arena.
It also features tropical foliage, five-star Tower Suites with separate swimming pools, and fine dining at its restaurants like the Wing Lei.
MGM Grand Hotel and Casino Las Vegas
Having operated on the strip for several decades, the MGM Grand Hotel is one of the best places to gamble in Las Vegas.
MGM offers a wide range of casino games like slot machines and card tables for both average and high roller players on its enormous expanse of land.
Caesars Atlantic City
Your best casino tours shouldn't end without you visiting this Roman-inspired resort at Atlantic City.
Not only does Caesars Casino offers several high-quality gambling entertainments, but it also features a 900-foot-long pier Playground where you can access their bars, shops, and restaurants.
Treasure Island Las Vegas
Located directly on the strip, you will be able to enjoy a wide range of table games, video poker, slots, poker, and sportsbook.
The resort features a variety of top-notch restaurants like Phil's Italian Steakhouse and Senor Frogs Las Vegas. Guest rooms at Treasure Island give you a perfect view of the Las Vegas mountains and the strip.
Foxwoods Resort Casino, Connecticut
Foxwoods Resort is the pride of the Connecticut gambling industry. Foxwoods Resort spans 340,000 square feet, making it one of the biggest casinos in the world.
Its ample gambling space boasts a wide range of casino games like Roulette, slot machines, and Poker.
Mohegan Sun Casino Connecticut
Mohegan Sun is also another grand casino located in Connecticut. Like its counterparts, Mohegan Sun covers a large area.
It offers everything you need in an excellent resort ranging from a vast collection of slots, poker rooms, and table games to top-notch restaurants like Bobby Flay's Bar American.
WinStar World Casino Oklahoma
You don't have to go to Las Vegas for a great gambling experience; Oklahoma offers it too! With over 500,000 square feet, WinStar World is one of the biggest casino and entertainment hubs in the whole world.
The casino offers lots of slot machines, numerous table, and bingo games. The resort also hosts several events and competitions.
WinStar World Casino is the biggest casino in the United States. Located in ThackerVille, Oklahoma, the resort seats over 600,000+ square of land. WinStar is also renowned for its large number of slot machines, table games, restaurants, and exclusive events.
Other notable mentions include Foxwoods Resort Casino, Mohegan Sun Casino, San Manuel Casino, and Riverwind Casino.
According to the GBGC (Global Betting and Gaming Consultants) 2015 report, the Wynn by Steve Wynn is the wealthiest casino in terms of revenue.
The casino records an overwhelming number of players annually due to its plethora of amazing offers like over 2,000 slot machines, 165 table games, and an exclusive Michelin-starred Chinese restaurant.
In 2014 alone, Wynn recorded an income of 0.69 billion dollars.
While gambling at a land-based casino is exciting, it has some limitations that you can easily bypass if you play online.
For instance, you don't have to leave your home to gamble at an online casino; since casino sites offer all the features, you'd expect to find at a physical casino and more.
Most online casinos are also compatible with mobile devices, allowing you to play anywhere and anytime.
In addition, online casinos usually offer a wider variety of games than brick-and-mortar casinos.
Sometimes, you will have to search through rows of slot machines at land-based casinos before you find your favorite game or wait your turn at table games.
However, thanks to the easily navigable layout of online casinos, you can effortlessly search and play your favorite game.
Most importantly, online casinos feature live casino games that give you a realistic casino experience right from home. These games allow you to play against real dealers in real-time, and you can also chat with the skilled dealers through a live chat feature.
So with all these exciting features, do you need to spend that much money on visiting a land-based casino? When you can play at new online casinos USA and have the time of your life!
The United States houses some of the best land-based casinos in the world. These top-notch casinos are renowned for their significant number of games, world-class restaurants, and other great features.
However, if you want a more comfortable and anonymous experience, you can have your fill of online gambling with many reputable online casinos in the United States.
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Pragmatic Play and Kaizen Gaming Extend Their Partnership – GamblingNews.com
Posted: at 10:53 pm
Pioneering content provider for the gaming industry, Pragmatic Play, has extended its relationship with Kaizen Gaming, one of Europes fastest-growing operators, to provide two verticals to the leading European community.
Customers will now be able to play Pragmatic Plays impressive live casino products through Kaizen Gamings iconic Stoiximan and Betano brands, which include the game show-style Mega Wheel and the exciting ONE Blackjack.
Pragmatic Plays slot items will now be available to Stoiximan customers through direct integration, allowing players to enjoy Pragmatic Plays Drops and Wins offering, as well as other promotional resources in the Enhance toolkit.
Vice President of Malta Operations at Pragmatic Play, Lena Yasir, said: Were very pleased to partner with one of Europes leading operators in Kaizen, as we take two verticals live across two leading brands.
Yasir further stated that Pragmatic Plays ability to extend collaborations so rapidly and seamlessly is a true testament to the depth of the companys offering, and the company looks forward to continuing to collaborate for a long time.
Kaizen Gaming has been pleased with Pragmatic Plays slot offering, so the company is excited to not only take their games through direct integration but also to add its outstanding Live Casino offering.
RNG Casino Manager at Kaizen Gaming, Dimokratis Papadimos also commented on the partnership by stating that Kaizen Gamings customer-centric approach prioritizes providing the best possible experience to those who entrust Kaiyen Gaming with their entertainment, and cooperation with Pragmatic Play has proven to be beneficial in this regard.
The business is looking forward to a long and fruitful friendship with them.
Christos Mavridis, Live Casino Manager at Kaizen, added: Pragmatic Plays Live Casino portfolio adds incredible value with its thrilling content and dedication to creating amazing igaming experiences, so were delighted to add that for our customers.
This agreement marks the providers continued commercial expansion into European regulated markets, utilizing Kaizen Gamings presence in Greece, Portugal, Romania, Germany, Cyprus, and Brazil.
Earlier in April Pragmatic Plays Live dealer portfolio games, including iconic games like Mega Wheel and Mega Roulette, as well as the providers well-known table games and new game-show-inspired titles, were made available to LuckyDays players.
Novibet and GGpoker customers already enjoy Pragmatic Plays Live Casino portfolio.
Novibet consumers are able to expand their gaming tastes even further by getting access to exclusive products that combine action with a nostalgic, TV-like look, promoting the suppliers cross-sell potential.
While GGPokers online casino also offers Pragmatic Plays Live Casino goods, including Mega Wheel and Mega Roulette, Pragmatics first game show-inspired games.
Random multipliers can be applied to any bet on any spin in the games, giving consumers the opportunity to increase their winnings.
GGPoker will sell the suppliers classics, such as Baccarat, Roulette, and Blackjack, as well as its Live dealer games, including ONE Blackjack and the soon-to-be-released Dragon Tiger.
In addition, to live casino and bingo games, Pragmatic Play currently publishes up to five new slot titles per month, all available via one single API.
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WashU, Pitt awarded $10.7 million for Alzheimer’s disease research Washington University School of Medicine in St. Louis – Washington University…
Posted: at 10:53 pm
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Study to look for genetic pathways that lead to formation of plaques, tangles
A $10.7 million, five-year grant will support a comprehensive study in which whole genome sequencing will be used to address critical gaps in knowledge about Alzheimer's disease. The project is led by researchers at Washington University School of Medicine in St. Louis and the University of Pittsburgh Graduate School of Public Health.
Despite decades of research and investment, the genetic underpinnings of Alzheimers disease are still largely unknown, stymieing efforts at drug development and early diagnosis. To change that, a new grant will support the first comprehensive study to use whole genome sequencing to address critical gaps in knowledge about the disease. The $10.7 million, five-year project is led by researchers at Washington University School of Medicine in St. Louis and the University of Pittsburgh Graduate School of Public Health.
Funded by the National Institute on Aging of the National Institutes of Health (NIH), the research team plans to identify the genetic variants, genes and pathways that lead to formation of plaques and tangles, two specific signs of disease called biomarkers that begin appearing in the brains of people with Alzheimers 15 to 25 years before they show symptoms.
Cruchaga
Genetic studies of measurable traits such as plaques and tangles provide advantages over other classic case-control studies, because these traits appear earlier and are more closely related to the biology behind the disease, said Carlos Cruchaga, PhD, a co-principal investigator of the study and the Reuben Morriss III Professor of Neurology at Washington University School of Medicine. In addition, studying these traits is more likely to lead to the identification of druggable targets along the genetic pathways that lead to disease. This genetic information can help us better predict disease risk at the individual patient level.
Cruchaga, also a professor of psychiatry, is working with co-principal investigator Ilyas Kamboh, PhD, a professor of human genetics and epidemiology at Pitt Public Health. Together, they plan to study as many as 5,000 participants at high risk for Alzheimers. The researchers will gather biomarker data to identify genetic variants that appear decades before clinical symptoms of the disease.
All of the clinical trials to find a drug to stop Alzheimers disease have failed because theyve focused on patients who already have developed the disease, so they already had high levels of plaques and tangles, said Kamboh. Once you have the plaques and tangles, it seems to be an irreversible process, so were focused on the preclinical stage of the disease.
According to the World Health Organization, Alzheimers disease is the most common form of dementia, with about 50 million cases worldwide and 6 million new cases each year. It is one of the major causes of disability and dependency among older people.
The plaques and tangles in the brain associated with Alzheimers can be thought of like cholesterol in the arteries of the heart and its association with heart disease, Kamboh explained. Cholesterol can quietly accumulate over years along the walls of the coronary arteries without causing symptoms until it causes a heart attack and does irreversible damage to the heart. Some genes predispose people to accumulate more cholesterol, and understanding that can allow people to take medication and make lifestyle changes that reduce the risk of heart disease. It also can prompt pharmaceutical companies to develop drugs that target the genetic pathways that lead to the formation of cholesterol deposits.
The new project will look for the genetic underpinnings of the plaques and tangles known to define Alzheimers disease and that formed due to abnormal accumulation of amyloid beta and tau proteins, respectively. Both can be detected early in the brains of living people through neuroimaging and the testing of cerebrospinal fluid.
In the past, we could detect these plaques and tangles only after death, through a brain autopsy, Kamboh said. Now we can identify them while people are living.
But those imaging and fluid-collection techniques are expensive and can be invasive.
New methods are now being developed to detect the presence of abnormal amyloid beta and tau proteins in less expensive blood tests, Cruchaga said. We hope that by learning more about the genes associated with the plaques and tangles, we might uncover underlying pathways that lead to Alzheimers disease and discover potential drug targets.
This study is supported by the National Institute on Aging of the National Institutes of Health (NIH). Grant number R01 AG064877.
Washington University School of Medicines 1,500 faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Childrens hospitals. The School of Medicine is a leader in medical research, teaching and patient care, consistently ranking among the top medical schools in the nation by U.S. News & World Report. Through its affiliations with Barnes-Jewish and St. Louis Childrens hospitals, the School of Medicine is linked to BJC HealthCare.
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Breaking Pick 4 Midday news: we have the winning numbers for today, Tuesday May 11, 2021 – Born2Invest
Posted: at 10:53 pm
Todays Pick 4 Midday results are in. Here are the winning numbers for Tuesday May 11, 2021
Ready to check your lottery ticket against the Pick 4 Midday results? We have you covered. Born2Invest instantly streams your Pick 4 Midday results at the end of every drawing.
Your Pick 4 Midday results for Tuesday May 11, 2021 are as follows:
Did you get lucky today or not? Remember, you can come back to this page shortly after each draw in order to find out if you are holding the winning numbers.
Incredible lottery opportunities you can play right now:
Need more options? Dont disregard games like Lightning Roulette, which features has a hand-crafted wheel, an immensely engaging and educated live vendor, and the full exhibit of roulette wagers. Additional options would be American Roulette, which is played on a wheel which presents 38 numbers containing boxes 0 and 00 or European Roulette. The European roulette wheel has 37 divisions, where numbers from 1 to 36 and 0 can be found.
They say you have a better chance of getting struck by lightning than at winning the lottery. If the math is right, the odds of winning in a pick-6 game is 1 in 14 million. Is it ever worth playing, or is it just a waste of money?
If youre looking for strategies on how to win, youll find that a lot of these tips dont work. Thats because, at the heart of it, the lottery is largely influenced by probabilities. But fear notyou can still follow these:
Did you know that?
Celebrities, authors and journalists have mused about the lottery for centuries. Among a sea of quotes, here are a couple of great ones about the lottery:
People would love to be rich, but theyre looking for the easy way. Who wouldnt want to win the lottery? Just to score. Bryan Cranston
My first audition was for a commercial for the lottery. I didnt get it, so I hate the lottery. Kat Dennings
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Heligenics & The Jackson Laboratory Announce New Collaboration on ERBB2 Breast Cancer Gene – PRNewswire
Posted: at 10:53 pm
LAS VEGAS, May 11, 2021 /PRNewswire/ -- Heligenics, Inc. today announced a new collaboration with The Jackson Laboratory (JAX). This joint project will make available the functional output of Variants of Unknown Significance (VUS) throughout key portion of the ERBB2 gene through the JAX Clinical Knowledgebase (CKB), a digital resource that connects clinicians and researchers around the globe in order to interpret complex cancer genomic profiles.
"This is a fabulous partnership that will help modernize and expand variant interpretation for key cancer genes," says Dr. Martin R. Schiller, CEO at Heligenics. "JAX is bringing a lot to the table and is a valued partner."
Heligenics' proprietary GigaAssay process measures causal functional impact of all mutants in a gene in 4 to 5 months while it takes other technologies decades to identify just a single marker. This collaboration will lead to future clinical trials, research grants, and publications to advance the fight against cancers, offering patients hope by identifying actionable ERBB2 variants for potential treatment.
CKB currently provides extensive information relevant to interpretation of cancer-related genomic data, including thousands of genevariant descriptions, therapies, as well as evidence of therapeutic efficacy, accessbile through a web-based application.
JAX-CKB can help increase clinician confidence in completeness and accuracy of the informationrelated to the patient's tumor genomic profile.For translational and clinical researchers, JAX-CKB provides thousands of literature citations, FDA drug labels,and clinical trials relative to a tumor's genomic mutational profile, resulting in a clear and up-to-datepicture of discoveries and active developments for a variety of biomarkers.
"Heligenics' GigaAssay technology has the potential to advance genomic interpretation, and we are excited for the opportunity to provide large scale interpretation of previously unknown genomic variants to our users, with the hope of connecting patients to relevant treatment options that otherwise may not have been identified," says Sara Patterson, Ph.D. manager, clinical analytics and curation at JAX.
The benefits of this new collaboration include:
"This collaboration with Heligenics will allow us to define new therapeutic targets for cancer patients," said Jens Rueter, M.D., medical director at JAX's Maine Cancer Genomics Initiative (MCGI). "Ultimately, this has the potential to lead to new treatment options for cancer patients, including the many patients and families affected by cancer in Maine."
Heligenics: Heligenics Incorporated, founded in 2018 to uncover the function of genetic variants on a massive scale for improved diagnostics and improved clinical trial design for developing new drugs.
Heligenics' key technology, the GigaAssay, was invented in the laboratory of Dr. Martin Schiller at the University of Nevada Las Vegas where he leads the Nevada Institute of Personalized Medicine. As the effect of most mutations on gene function is largely unknown, Heligenics comprehensively measures the functional significance of mutations in the human genome and has exclusive rights to the patent pending GigaAssay technology. To learn more, please visit http://www.Heligenics.com.
The Jackson Laboratory (JAX): Founded in 1929, JAX pioneered the use of mice as models for human disease. As an independent, 501(c)3 nonprofit biomedical research institution, JAX uniquely integrates its deep experience in mouse genetics with ground-breaking advances in human genomics to decipher the biological and genomic causes of human disease and drive medical progress.
JAX research breakthroughs have formed the foundation of modern medicine. Organ and bone marrow transplants, stem cell therapies, and in vitro fertilization all have a foundation in JAX research, and at least 26 Nobel Prizes are associated with JAX research, mouse models, and education programs.
Media Contact:
Heligenics, Inc.(415) 794-3403[emailprotected]
JAX Press TeamThe Jackson Laboratory(860) 837-2102[emailprotected]
SOURCE Heligenics, Inc.
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Heligenics & The Jackson Laboratory Announce New Collaboration on ERBB2 Breast Cancer Gene - PRNewswire
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COVID-19 one year into the pandemic: from genetics and genomics to therapy, vaccination, and policy – DocWire News
Posted: at 10:53 pm
This article was originally published here
Hum Genomics. 2021 May 10;15(1):27. doi: 10.1186/s40246-021-00326-3.
ABSTRACT
COVID-19 has engulfed the world and it will accompany us all for some time to come. Here, we review the current state at the milestone of 1 year into the pandemic, as declared by the WHO (World Health Organization). We review several aspects of the on-going pandemic, focusing first on two major topics: viral variants and the human genetic susceptibility to disease severity. We then consider recent and exciting new developments in therapeutics, such as monoclonal antibodies, and in prevention strategies, such as vaccines. We also briefly discuss how advances in basic science and in biotechnology, under the threat of a worldwide emergency, have accelerated to an unprecedented degree of the transition from the laboratory to clinical applications. While every day we acquire more and more tools to deal with the on-going pandemic, we are aware that the path will be arduous and it will require all of us being community-minded. In this respect, we lament past delays in timely full investigations, and we call for bypassing local politics in the interest of humankind on all continents.
PMID:33966626 | DOI:10.1186/s40246-021-00326-3
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‘Causal’ blood pressure genes found in the human kidney – The University of Manchester
Posted: at 10:53 pm
An international team of scientists led by The University of Manchester have discovered 179 kidney genes responsible for high blood pressure.
High blood pressure, known as silent killer, is one of the most common human diseases and remains the key risk factor for strokes and heart attacks.
High blood pressure - orhypertension- runs in families but the exact mechanisms through which genes influence individuals predisposition to hypertension is not clear.
The discoveries published in Nature Genetics, one of the worlds leading journals, shed new light on our understanding of genetic predisposition to high blood pressure.
The study, supported primarily by the British Heart Foundation and Kidney Research UK, was possible through access to huge datasets of human DNA and RNA from possibly the worlds largest repository of human kidney tissue-based omics.
The team led by Professor Maciej Tomaszewski at The University of Manchester characterised how information inherited in DNA translates into genetic predisposition to high blood through changes in activity of certain kidney genes.
These studies included comprehensive analyses conducted at various molecular levels of kidney tissue combining together DNA, RNA and other layers from the same set of kidney tissue samples.
They also used a statistical method - called Mendelian randomisation to screen for evidence of causal associations between thousands of variables and millions of genetic variants using the high-performance computing resources hosted at the University of Manchester.
Around 80 per cent of 179 genes discovered by the team have never before been associated with high blood pressure before. Some of these genes can be targeted by existing medicines creating new opportunities to treat high blood pressure.
Principal Investigator Maciej Tomaszewski, Professor of Cardiovascular Medicine and University of Manchester and a Consultant Physician said: Hypertension is a key driver of coronary heart disease and stroke and the single most important cause of disability and premature death worldwide.
Yet, our understanding of the role of genes in development of this condition has been incomplete.
Professor Tomaszewski is also a member of Manchester Academic Health Science Centre (MAHSC), a partnership between academia and NHS organisations in Greater Manchester to drive health research, improve health education and transform patient care.
Professor Fadi J Charchar, a senior author from Federation University, added: Our studies filled an important gap in our knowledge through uncovering new genetic variants, kidney genes, molecular mechanisms and biological pathways of key relevance to genetic regulation of blood pressure and inherited susceptibility to hypertension.
Professor Andrew Morris, from The University of Manchester, commented: Through our unparalleled access to the kidney tissue resource, we provide evidence for the role of the kidney as the mediator of common genetic effects on blood pressure and a potentially causal role of blood pressure in the development of renal disease.
First author: Dr James Eales from The University of Manchester said: By explaining the molecular mechanisms of hypertension embedded in the kidney, our study will ultimately lead to advancements in patient-centred diagnostic accuracy in hypertension.
It will also lead to new targeted strategies to lowering blood pressure, thereby accelerating progress in precision medicine.
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'Causal' blood pressure genes found in the human kidney - The University of Manchester
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