Monthly Archives: April 2021

AHA Through the Years – TheHumanist.com – The Humanist

Posted: April 15, 2021 at 6:40 am

The following excerpt from Roy SpeckhardtsCreating Change Through Humanism(Humanist Press, 2015) is part of theHumanist.coms month-long celebration of the AHAs 80th Anniversary in April.

Humanism has an impressive history. With deep roots in the early Greek philosophers and in Eastern thinkers well before them, humanism grew during the Renaissance. It continued to develop throughout the Reformation, Enlightenment, and scientific revolution and began to take its present shape in the late nineteenth century. As it took its present form it drew in knowledge and wisdom from still more sourcesfrom Jawaharlal Nehru to Nelson Mandela and more.

Beginning in 1927, a number of Unitarian professors and students at the University of Chicago who had moved away from theism organized the Humanist Fellowship. Soon they launched theNew Humanistmagazine, offering a path forward for the Unitarian movement. But most of the other church members were still thinking in terms of a capital G God as the glue necessary to bind ideas to people and people to each other.

Around the same time, Charles Francis Potter founded the First Humanist Society of New York. Formerly a Baptist and then a Unitarian minister, Potter began the society with the intent of it being a religious organization, calling humanism a new faith for a new age. Prominent members of this community included John Dewey, Julian Huxley, and Albert Einstein. Potter wrote a book entitledHumanism: A New Religion, outlining the basic premise and points of what he termed religious humanism. His philosophy openly rejected traditional Christian beliefs and replaced them with a humanist philosophy that incorporated various aspects of naturalism, materialism, rationalism, and socialism. Potters intent was to offer an ever-evolving philosophy that would update itself as new knowledge was gained.

A major humanist milestone was achieved in 1933 whenA Humanist Manifestowas written through the collaboration and agreement of thirty-four national leaders. This was a publicly signed document detailing the basic tenets of humanism. By 1935 the Humanist Fellowship was supplanted by the Humanist Press Association.

The American Humanist Association (AHA) was formed in 1941, when Curtis W. Reese and John H. Dietrich, two well-known Unitarian ministers and humanists, reorganized the Humanist Press Association in Chicago, into the American Humanist Association.

The goal was not to establish a religion as Potter had originally intended but instead to recognize the nontheistic and secular nature of humanism, organize its advocates, and align the organization for the mutual education of both its religious and nonreligious members. This makes the American Humanist Association the oldest organization addressing the breadth of humanism in the United States. The AHA began publishing theHumanistmagazine as the successor to the earlier publications, setting out to explore modern philosophical, cultural, social, and political issues from a humanist point of view.

At the end of the 1940s, the organization was supportive of Vashti McCollum in her fight against religious instruction in public schools. The mother of two boys, McCollum argued that religious instruction in public education violated the principle of separation of church and state. Her case traveled all the way to the US Supreme Court where, in 1948, she achieved a watershed ruling in her favor. In 1962, McCollum became the first woman to serve as AHA presidentlong before a number of Christian denominations began to ordain women.

Running parallel with this localizing and personalizing of the humanist philosophy was the empowerment of women within the organization. The second editor of theHumanistwas Priscilla Robertson, whose work began in 1956. One of the earliest of the AHAs Humanists of the Year was Margaret Sanger who received that award in 1957, honored for her activism for birth control and sex education. But Sanger was just the first of many of the leading feminist and reproductive rights activists to work closely with the AHA. Just among those in this category who received the AHAs top award were Mary Calderone and Betty Friedan in the 1970s, Faye Wattleton and Margaret Atwood in the 1980s, Kurt Vonnegut and Barbara Ehrenreich in the 1990s, and most recently Gloria Steinem in 2012.

In the 1960s, the AHA became active in challenging the illegality of abortion. It was the first national membership organization to support abortion rights, even before Planned Parenthood expanded to address the issue. Humanists were instrumental in the founding of leading pro-choice organizations, such as NARAL Pro-Choice America, which continue to defend and support elective abortion rights.

Humanism and the AHA reached another milestone during the 1970s when the AHA released a major new humanist text,Humanist Manifesto II. Drafted by Edwin H. Wilson and Paul Kurtz, the work was released in 1973 to unprecedented media fanfare including a New York Timesin-depth, front-page article exploring humanist philosophy and the new manifesto. Welcomed by many commentators, the manifesto was denounced by religious conservatives as anti-religious and anti-God.

Following this release, the AHA continued on its energized path of starting new endeavors and publishing major statements on death with dignity, objections to astrology, support of sexual rights, evolution, and discrimination in the workplace.

The 1980s saw the beginning of an onslaught of attacks by the Religious Right against secular humanism and the AHA. In an attempt to counter the smears, the AHA began its own campaign, which included media appearances, public debates, nationally published articles, press conferences, lobbying, and legal action. Interested in this debate, world-renowned author Isaac Asimov joined in as the elected president of the AHA in 1985.

As the AHA celebrated its fiftieth anniversary in 1991, theHumanistbecame a major alternative medium for social and political commentary. Through such efforts, the magazine has attracted and published the writing of such luminaries as Alice Walker, Lester R. Brown, Aung Sung Suu Kyi, Noam Chomsky, Ted Turner, and many other leading journalists, writers, political leaders, and activists.

Kurt Vonnegut was named Humanist of the Year in 1992 and went on to become the AHAs honorary president. Always true to his character, Vonnegut wrote a decade later to the AHA offices: Find here my permission for you to quote any damn fool thing Ive ever said or written, through all eternity, and without further notice or compensation to me.

The AHA was one of the first organizations to become fully active online with the introduction of its website in 1995. It remains a leader in online and social media communications with hundreds of thousands of followers throughout its active presence on Facebook, Twitter, and Instagram.

One of the AHA leaderships biggest decisions was to move the organization to Washington DC. Previously the AHA had moved from Yellow Springs, Ohio, to San Francisco, California, to Amherst, New York. Matters of convenience and economy had dictated the selection of each of these locations. But now the organization made a strategic choice: A move to Washington DC would take humanism to the center of power and influence.

This wouldnt have been possible without the support of the AHAs endowment fund, now called the Humanist Foundation, along with a seed grant from Lloyd Morain for a building in the nations capital. Relocation to the new Humanist Center was completed in 2002 under the leadership of Executive Director Tony Hileman. Through this move, the AHA was empowered to substantially increase the humanist voice in the public debate. [In 2017, the AHA made another move to an upgraded national headquarters in the heart of Washington, DC.]

The philosophy of humanism itself took a major evolutionary step in 2003 with the release ofHumanism and its Aspirations, the third humanist manifesto, signed by two dozen Nobel Prize winners. More concise than its two predecessors, the third manifesto set out to continue the trend of clarifying the humanist philosophy in a way that paid tribute to core humanist values while challenging humanists to take action toward making this world a better place.

It was in DC where the AHA began to take advantage of best non-profit practices, achieving full ratings by charitable accountability organizations such as the Better Business Bureau, Charity Navigator, and GuideStar. The AHA maintained and improved theHumanistmagazine, created the weekly digital newsletter theHumanist.com, and added theEssays in the Philosophy of Humanismpeer-reviewed journal.

The gradual conversion of the organization, from a merely philosophically forward-looking organization to its current capability to actually accomplish humanistic change, created a new environment where advocacy for humanist values became the AHAs focus.

Looking ahead, the American Humanist Association, its members, chapters, affiliates, and publications vow to not only support and defend core humanist values but also to press the public to consider and discuss humanist issues and social concerns. Guided by reason and humanitys rapidly growing knowledge of the world, by ethics and compassion, and in the pursuit of fuller, more meaningful lives that add to the greater good of society and humanity, the members of the AHA envision a world of mutual care and concern where the lifestance of humanism is known and respected, and where people take responsibility for the world in which they live.

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Bengal Elections: EC Biased, Giving Concession to TMC and BJP, Alleges CPI(M) – NewsClick

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Kolkata: The Communist Party of India (Marxist)s West Bengal state secretary alleged that the Election Commission is biased and accused it of allowing undue concessions to the ruling parties at both the Centre and in West Bengal, at a press conference on April 8.

The veteran CPI(M) leader was addressing a press conference at the Press Club in Kolkata, where he alleged that the EC has been prejudiced over the air transmission of the Prime Minister and other political leaders speech on poll days in West Bengal where Assembly elections are currently underway.

Notably, the serious allegation against the Election Commission has come at a time when the CPI(M) as well as the Sanjukto Morcha, the electoral alliance of which the Left party is a part, have been restrained over its comments on any quasi judicial body.

Dr Mishra alleged that the dates for the different phases have been arranged in such a manner that a single district is going to polls in several phases. As a result, speeches targetting live voters are being aired, but have been ignored by the Election Commission despite violating norms.

He also took a shot at incumbent Chief Minister Mamata Banerjee for urging the voters, particularly in rural areas, to confront the central forces and criticised her for camping at a booth for over two hours. He further alleged that the elections are held in an atmosphere of communal polarisation created by the BJP and TMC and added that democracy and secularism are under attack by these forces.

Not only that, the CPI(M) state secretary levelled allegations against the central police force and a section of media who are trying to increase the politics of polarisation. The corporate funded elections are beneficial for the BJP and also the TMC, he claimed. We are telling the people that a vote to TMC will be like voting for BJP and vice versa. TMC cannot fight against the BJP, he said.

Highlighting that Election Commission is changing officers rapidly without any real gains, Dr Mishra said that the EC is adhering to the ruling partys demands, not checking the EPIC cards of central forces being one among such demands.

While rationalism is under attack, the Bihar election results have shown that the popular mandate is still with rationalists a fact visible from the minimum difference in vote share, he said, adding that allegations of CPI(M) of having a hand in poll attacks are false.

The Left leader also denied suggestions that the SM will extend support to the the TMC in case of lesser numbers, adding that there aim is to defeat both TMC and BJP by over 50% votes.

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Education, and pedagogy: Why we need de-schooling – Free Press Kashmir

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Our society has fabricated a self-pitiable education system in which qualifying exams has become a delusional testimony of how good or bad a person is.

A person who doesnt perform well in solving meaningless tasks of school program mostly monotonous, unimaginative, counter creative and barren are looked down upon as inferiors and face a life long social rejection while others are made to believe that they are valuable because they could fit into the uncreative monotony of a lifeless repetition.

Yes, a lifeless repetition, reducing the idea of expression to a mere function of capitalist utopia and completely doing away with emotions, experience and authenticity.

Dostoevsky had started warning against such utopianism. Converting human being into a pianno key, a rational computer, a robot.

He was followed by people like Nietzsche, Freud, Marx, Jung, Adler, who showed to the western man that the problem with preaching thorough going rationalism, rational episteme, rational (blinding horizontal) mentality is that they wouldnt be even aware & their subconscious & unconscious would be dragging them to places.

This capitalist utopia sorts us into categories from the very childhood.

I remember when we were in school we were taught not to sit with, or befriend, those who were weaker students than us. One of our famous professors would tell us that if we didnt study we would end up being dukandaars. There were backbenchers and front seaters. When we could hardly differentiate a right from a wrong we had already been moulded into judging and discriminating between them and us, doctor and dukandaar, superior and inferior, material prosperity and poverty, we were initiated on a Capitalist note and its profit driven definitions of right and wrong.

Capitalism-inspired education got us into the habit of measuring things, and of believing that what cant be measured is either valueless or threatening.

The system trained students to conform to an alienated and class-stratified society, a society passive to realities of a social(ist) life. The class system in schools indoctrinated some children into feeling inferior to others, while others start believing they are better than the rest.

And it is this belief that the education system nurtures, the belief that some people are less valuable than others, hence helping in perpetuation of inequality and discrimination. The discrimination, the covet capitalist agenda is inculcated through a hidden curriculum that bases itself on principles of external rewards, subservience to the bourgeois norms, and an utmost focus on competition rather than team work.

Fidel Castro compares competition to hypocrisy and war when he finds capitalism repugnant, filthy, gross and alienating because it causes war, hypocrisy and competition.

Capitalist pedagogy reduced student achievement to mere income and employment, with absolutely no role in social justice and inclusion. It laid the cornerstone of the neo-liberal consumerism which has plagued the whole social fibre of the world.

As Michael Moore said, Capitalism is an organized system to guarantee that greed becomes the primary force of our economic system and allows the few at the top to get very wealthy and has the rest of us riding around thinking we can be that way, too if we just work hard enough, sell enough Tupperware and Amway products, we can get a pink Cadillac.

The greed is imbibed from the earliest, through a reward driven repetitions of school system.

Schools in the current times are institutions set up to fulfil the popular political narratives. Spending the first quarter of their life in school, children are taught to do exactly what they are asked to. They are indoctrinated into conformism, and scepticism towards the higher authority is discouraged.

They are subtly manipulated into believing in the infallibility of official figures and accounts. They grow up with a notion that large media agencies are the most trusted source of information. Focus on life skills, civil freedoms and liberties is diminished. Once children leave the capitalist school they are unable to question its authority, they are rendered incapable of their own observations about the nature of events and are unable to find a meaning in anything beyond what is proposed by the political.

Kozol wrote in 1975: School does not exist to foster ethics and upheaval. It exists to stabilize the status quo. It exists to train a population which is subject to the power of such instruments of mass persuasion as the social order has at hand. It exists to get its citizens prepared for moral compromise. The first and primary goal of the U.S. public school is not to educate good people but good citizens. It is the function which we call in enemy nations,state indoctrination.

The only point of view possible to us (including me) is the capitalist point of view.

Capitalist philosophy has assumed almost an ontological form. It is crime against current standards of humanity to question science and its industry, to doubt the education and its indoctrination, to put class segregation and its watchdogs at stake, to see prodigious mechanisation as gigantic rape of everything intimate. Anything sane spoken against those these scandalous standards sounds outrageous.

And it is precisely this that all of us need de-schooling, if we want a social change.Khawar Khan Achakzaiis a published author, a medical Doctor by profession, and a student of history.

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Revisiting the Life and Intellectual Legacy of Primo Levi jacobinmag.com – Jacobin magazine

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It would be banal and nevertheless true to emphasize how much we miss the voice of Primo Levi today, in times of rising xenophobia, racism, and far-right movements, at a time in which public intellectuals have almost disappeared in Italy. But lamentation was never Primo Levis style of thought, and is best avoided.

The destiny of classics is to be permanently reinterpreted, and Levi does not escape this. There are, however, certain misconceptions concerning his legacy. His relation to Enlightenment thought, his definition as a Jewish writer, and, last but not least, Levis role as a literary witness of the Holocaust a word he disliked and with which today he is completely identified have been misconstrued in recent decades.

Over twenty years ago, the Italian philosopher Giorgio Agamben wrote Remnants of Auschwitz, a remarkable book built on a sort of posthumous dialogue with Primo Levi, notably through a rereading of his last essay, The Drowned and theSaved (1986). Drawing on Levi, Agamben proposed a vision of the extermination camps as the secret law of Western civilization and the naked life of the deported (the Muselmann) as the modern expression of its underlying paradigm, homo sacer.

By invoking Levi in this way, Agamben unwittingly encouraged the misconception that the author of If This Is a Manwas somehow the forerunner of a radical break with the Enlightenment tradition. But, in fact, it was that very tradition that defined the philosophical horizons of Primo Levi. He may have pushed this tradition to its limits, almost putting it into question, but Primo Levi remained a critical enlightener, a writer for whom reality was a material, anthropological, cultural, and historical product rather than a linguistic construction or a semantic structure. In spite of their missed dialogue, he probably shared Jean Amrys stoic claim of a positivist spirit: the spirit of somebody who believes in experience, who clings to reality and its enunciation.

Classicism and positivism are the pillars of Levis first books. If This Is a Man (1947) is shaped into the model of Dantes Inferno deportation as a fall into Hades, the camp with its circles, the inexhaustible variety of the pains inflicted on the inmates, and the great diversity of its characters, from his suffering comrades to the omnipotent torturers whereas The Truce (1963) tells of his coming back to life: the journey that allowed him, after his liberation from Auschwitz in January 1945 and an interminable peregrination throughout Central Europe, to reach his home in Turin.

Besides Dantes literary model, If This Is a Man reveals a second, fundamental source, which is a scientific paradigm: the legacy of a chemist who describes, orders, classifies, and scrutinizes the overwhelming experience endured in Auschwitz. The literary sensitivity of the writer and the analytical gaze of the chemist are the foundations of his entire work. The Nazi camps were for him an anthropological laboratory in which, besides the serial destruction of lives, the human condition revealed its extreme limits. Of this anthropological laboratory, Levi was first a fragment what the Nazi lexicon called technically a piece (stck), i.e., a victim and then a witness; even more than a witness: an analyst.

Witnesses always filter their experience through their own culture, select and interpret their recollections according to their own knowledge and questions. Witnesses ask themselves what is the meaning of their suffering, and their answers are neither unique nor immutable. In the eyes of Levi, the Holocaust remained a black hole, a definition borrowed from the language of natural sciences, but this mysterious abyss had to be explored, studied, and possibly understood. He explained this is the legacy of his books that it is impossible to investigate the Nazi camps without the testimony of the deportees. The point was not to add a touch of color or authenticity to a whole of facts clearly established; the point was to use an irreplaceable source for understanding the extermination camps, for penetrating both the phenomenology and the meaning of an experience that transcended the archival materials and whose evidence its architects had tried to erase. This is why If This Is a Man has become a fundamental link in the chain of an open discussion on the conflicted yet nonetheless vital relationship between memory and history.

This posture reveals a form of rationalism that Levi had inherited from his scientific education, a rationalism that guided his career as a chemist and became a permanent feature of his mind. One of the lines describing the diagram that opens his personal anthology, The Search for Roots, reads the salvation of understanding (la salvazione del capire). It is marked by four names tracing, from antiquity to the twentieth century, a scientific and rational canon that inspired his intellectual journey: Lucretius, Darwin, Bragg, and Clarke. As Levi stressed during his conversations with Tullio Regge, he was attached to a romantic vision of science: a science with a human face, he said, that carried on the joyful explorations of the Renaissance and Enlightenment scholars, opposed to the lethal performances of instrumental reason. In his few science-fiction stories, he warned against Promethean and totalitarian projects for dominating nature and annihilating humankind by means of modern technology.

Primo Levis work thus has to be put under a pre-Foucault lens, even if his definition of Auschwitz as a gigantic biological and social experience clearly suggests a definition of National Socialism as what Foucault called a biopolitical power. This is an example of how Levi reinterpreted and pushed to the limits the classical tradition from which he came.

It is interesting, from this point of view, to compare Levi with Jean Amry (Hans Mayer), the Austrian writer and critic and author of Jenseits von Schuld und Shne who was also deported to Auschwitz (where he pretended to have met Levi). Amry too claimed the legacy of the Enlightenment, which he defined as a kind of philosophia perennis; he never denied his intellectual roots in the tradition of Austrian logical positivism; and he did not hesitate to defend Jean-Paul Sartres humanism against the offensive of French structuralism, which he perceived as a betrayal. Interpreting history as the structuralists did as a process without a subject was nonsense, and the epistemological posture of Foucault, who stunningly proclaimed the death of subject, appeared to him as a provocation coming from the most dangerous enemy of Enlightenment (der gefhrlichste Gegenaufklrer).

As staunch Aufklrer (enlighteners), Levi and Amry did not endorse irrationalism or mysticism, and certainly would not have subscribed to Elie Wiesels famous sentence defining the Holocaust as an event transcending history but a gap remained between explaining (spiegare; erklren) and understanding (capire; verstehen). Critical reason might explain Nazi violence and grasp its roots, describe its historical background and deconstruct its context, distinguish its steps and indicate its actors, analyze its internal logic and point out its peculiar combination of archaic mythology and rational modernity, a spiral resulting in complete destruction but this is not yet understanding. All in all, Auschwitz remained, in their eyes, a black box of understanding: Levi defined it a black hole (un buco nero) and Amry a dark riddle (einem finsteren Rtsel).

The attempts to explain the Holocaust through a Sonderweg (special path) in which, from Luther to National Socialism, Germany would have deviated from the path of a supposed Western paradigm of modernity, were naive ways out, just like the Marxist efforts to grasp in the Nazi crimes sometimes an economic rationality and sometimes a symptom of a late capitalist eclipse of reason. To the eyewitness, none of these explanations were satisfactory none of them were able to resolve this black hole or dark riddle.

This posture should not be confused with that later formulated by Claude Lanzmann, the filmmaker of Shoah, which often took a mystical, almost obscurantist slant. Neither Amry nor Levi posited the incomprehensibility of the Holocaust hier ist kein warum (there is no why) as a dogma that automatically stigmatized as obscene any attempt to historical understanding. Amry and Levi did not consider the Holocaust as a non-realm of memory (non-lieu de mmoire), a trauma that could only be resurrected by testimony but neither transmitted nor historicized. They never thought to celebrate a defeat of the intellect. Not only did such a mystical posture not correspond with their mental constitutions they probably would have rejected it as both ethically and politically unacceptable.

The second widespread misunderstanding of Primo Levi deals with his Jewishness: the tendency to classify him as a Jewish writer. Undoubtedly, Levi was a Jew. He never tried to hide this obvious fact: he had been persecuted and deported to Auschwitz as a Jew and spent most of his intellectual life bearing testimony to the Nazi extermination of the European Jews. Nonetheless, he was not a Jewish writer like Elie Wiesel, Aharon Appelfeld, or Philip Roth, to mention some of his contemporaries. The Italian-Jewish writers of the twentieth century deeply differed from their Israeli fellows, as well as from the New York intellectuals, however diverse the latter could be. Not only did he never consider himself the representative of a religious community his attachment to the tradition of science and the Enlightenment implied a radical form of atheism, which his experience of deportation strongly reinforced, even if he always expressed respectful feelings toward believers but he probably never felt part of a Jewish milieu with clearly defined social and cultural boundaries.

Rather than as an Italian Jew a definition in which Jew is the substantive and Italian the adjective he preferred to depict himself as an italiano ebreo, a Jewish Italian.

Interviewed by Risa Sodi after his successful lecture tour of the United States in 1985, he stressed that in Italy the notion of Jewish writer was very difficult to define. There, he said, I am known as a writer who, among other things, is Jewish, whereas in the United States he felt as if [he] had worn again the Star of David! Of course, he was joking, but he wished to emphasize that his education and his cultural formation had not been particularly Jewish, and that most of his friends as well as the overwhelming majority of the Italian readers of his books were not Jewish. In a lecture given in 1982, he admitted that he had finally resigned himself to accept the label of Jewish writer, but not immediately and not without reservations. This remark could be extended to most Jewish writers of twentieth-century Italian literature, from Italo Svevo to Alberto Moravia, from Giorgio Bassani to Natalia Ginzburg, and many others.

Between 1938 and the end of the Second World War (i.e., between the promulgation of fascist racial laws and his liberation from Auschwitz), Levi probably fit the famous Sartrian definition of the Jew: The Jew is one whom other men consider a Jew . . . for it is the anti-Semite who makes the Jew. In a conversation with Ferdinando Camon, he mentioned his Jewishness as a purely cultural fact. If not for the racial laws and the concentration camp, he said, I probably would no longer be a Jew, except for my last name. Instead this dual experience, the racial law and the concentration camp, stamped me the way you stamp a steel plate: at this point I am a Jew, they have sewn the star of David on me and not only on my clothes.

Levi certainly was a Godless Jew (gottloser Jude), as Peter Gay depicted Sigmund Freud, but he probably would not have inscribed himself into the noble gallery of those whom Isaac Deutscher called the non-Jewish Jews (i.e., the Jewish heretics). After the war, Primo Levi did not feel targeted by antisemitism and considered emancipation from religious alienation and obscurantism a legacy of the Enlightenment rather than a task of the present. He did not consider himself an iconoclast or a dissenter within Judaism. He simply was not a believer or a religious man.

In many articles and interviews, Levi repeatedly affirmed that his Italian roots shaped his way of writing books such as The Periodic Table and The Wrench celebrate the Piedmontese Jewish culture and even the Piedmont dialect but had to be projected into a broader world. Auschwitz was the paradoxical site where, as an Italian Jew, he discovered cosmopolitanism. One of the first chapters of If This Is a Man significantly titled Initiation depicts the camp as a Tower of Babel where people spoke dozens of languages and where the capacity to overcome these linguistic boundaries became a condition of survival. Like The Truce, the book offers an extraordinary gallery of characters belonging to different cultures, from Poles to Russians, from Ukrainians to Greeks, from Frenchmen to Germans, as well as to different social layers, but merged in a world in which all traditional cleavages and hierarchies were turned upside down. Whereas in Italy, as a Jew, he was a member of a minority, in Auschwitz his particularism was Italian, not Jewish.

In both If This Is a Man and The Truce, his Italian origins become a prism through which he discovers and describes other cultures distant and unknown to him. This is true, first of all, for Yiddish culture, which appeared very strange, not to say exotic, to an Italian Jew. But he also reversed this gaze: in the eyes of a Russian or Polish Jew, the image of a Jew in a gondola or at the top of Vesuvius was just as exotic. Today, Auschwitz has become the locus par excellence of a Western memory of the Holocaust, but the world he described in such a colorful and sympathetic way is an Eastern Jewish, Slavonic, Yiddish, Central European, and Balkan world. And the richness of his books lies in this contrast. In Auschwitz, he learned of the existence of a national Jewry, with its own language and culture, made of traditions, practices, and rituals. His last novel, If Not Now, When? , is a saga of the Jewish resistance in Poland, experienced as a sort of national redemption. He was fascinated by this Judaism, a Judaism of which he had learned the history, celebrated the greatness, and mourned the destruction, but which was not his own.

Against the clich portraying the modern Jewish intellectual as a figure of exile and extraterritoriality, Levi was a striking example of rootedness in a national society, language, and culture. We could almost speak of physical roots, if we simply recall the words with which he evoked his family house in Turin, where he was born on July 31, 1919, and where he committed suicide on April 11, 1987. Presenting himself as an extreme example of sedentary life, he wrote that he had become encrusted in his apartment as seaweed fixes itself on a stone, builds its shell and doesnt move any more for the rest of its life. He passionately described the streets, the river, and the surrounding mountains of Turin, as well as the austere and industrious character of its inhabitants. In 1976, he portrayed his town with the following words:

I am very linked to my little fatherland (patria). I was born in Turin; all my ancestors were Piedmontese; in Turin I discovered my vocation, I studied at University, I have always lived, I have written and published my books with a publisher very rooted in this town despite its international reputation. I like this town, its dialect, its streets, its paving stones, its boulevards, its hills, its surrounding mountains I scaled when I was young; I like the highlander and country origins of its population.

In short, he was a rooted writer, who needed a deep anchorage in a particular social, cultural, national, and even regional background in order to express the universality of his themes and messages.

Maybe, he added, it was because of this remarkable rootedness that journey was the topos of so many of his books. Just as his melancholic Enlightenment was antithetical to the cult of science and conquering technology, his sedentary life was neither provincial nor nationalist. For him, science was not a blind, instrumental rationality, but rather a universal language inseparable from classical humanism (a category he never put into question, unlike postmodernists or structuralists); likewise, his Italian identity, both Jewish and Piedmontese, was able to enter into dialogue with any culture, just as how Faussone, the hero of The Wrench, traveled around the world to build bridges, barrages, and power plants.

A third misunderstanding of Primo Levis work deals with his role as a witness. After his death, he has been canonized as a witness par excellence of the Holocaust, and thus achieved the status of a paradigmatic victim which he did not have during his life. He wrote most of his books at a time in which the Holocaust had not yet entered our common historical consciousness as a central event of the twentieth century or even, in broader terms, of Western civilization. When he published If This Is a Man, the word Holocaust did not exist for defining the Nazi extermination of the Jews, and, later, he pointed out that this word, etymologically meaning a sacrifice offered to the gods, was inappropriate, rhetorical, and, finally, mistaken.

The memorial turn in Western culture the rise of memory as a central topic of public debates, the cultural industry, and academic scholarship took place precisely in the middle of the 1980s. Its symbolic landmarks were successful works such as Zakhor by Josef Hayim Yerushalmi in the United States; Realms of Memory, the collective volumes edited by Pierre Nora, and Shoah, a nine-hour movie by Claude Lanzmann, in France; the so-called Historikerstreit around the Nazi past that will not pass in Germany; and The Drowned and the Saved by Primo Levi himself. Thus, Levi powerfully contributed to the emergence of memory in the public sphere, but this happened at the end of his life and most of his work should be located before this memorial turn. He observed this change with a critical eye I would say with a certain skepticism and felt unsettled by this metamorphosis in both the perception and the representation of the past, as his last, testimonial essay clearly shows.

Two features of this new era of commemorations are particularly significant: first, the transformation of the remembrance of the Holocaust into a sort of civil religion of the West and, second, its separation from the memory of anti-fascism, which had been a dominant memory for three decades in postwar Italy. The civil religion of the Holocaust aims at making sacred the foundational values of our democracies by commemorating the Jewish victims of National Socialism in a liturgical, institutionally ritualized way. It turns the survivors into iconic figures who witness violence and human suffering in their own bodies in short, homines sacri in the opposite sense of Agambens definition: not the ones permissible to kill but rather the selected ones to be commemorated.

Many of Levis remarks in his last essay, The Drowned and the Saved, today sound like warnings against the dangers of this civil religion of the Holocaust. He always rejected the temptation to turn victims into heroes. He refused to present the survivors as the best, those who put up the most relentless resistance to oppression. As he explained, his survival in Auschwitz was fortuitous, simply a matter of luck: the chemistry exam that spared him from being immediately selected for the gas chambers; the extra soup ration which he received daily from his friend Lorenzo Perrone; and his sickness, in January 1945, at the moment of the evacuation of the camp, which spared him the death marches. Thus, he deliberately chose to write If This Is a Man by adopting the calm and sober language of the witness, not the complaining voice of the victim, nor the angered tone of revenge.

Levi refused to judge and played his role as a witness with great humility: The history of the Nazi camps has been written almost exclusively by those who, like myself, never fathomed them to the bottom. Those who did so did not return, or their capacity for observation was paralyzed by suffering and incomprehension. The survivors could witness their experience, a fragment of the historical event in which they had been involved, but their testimony did not reveal any transcendent truth. In other words, the drowned (sommersi) who had been swallowed up by the gas chambers could not come back to bear witness. They, rather than the survivors, were the complete witnesses.

In The Drowned and the Saved, he wrote that the survivors were not only an exiguous but also an anomalous minority; they were those who by their prevarications or abilities or good luck did not touch bottom. Those who did so, those who saw the Gorgon, have not returned to tell about it or have returned mute, but theyre the Muslims, the submerged, the complete witnesses, the ones whose deposition would have general significance. They are the rule, we are the exception.

When Levi wrote about the ethical and political duty of witnessing carried out by the Holocaust survivors, this formula had not yet become a rhetorical ploy of the dominant discourse on memory. He stressed that the survivors not only could not, but would not forget, and wanted the world not to forget, because they felt forgetting to be the most dangerous threat. Overcoming the past (die Bewltigung der Vergangenheit): this catchword, Levi observed, is a stereotype, a euphemism of todays Germany, where it is universally understood as redemption from Nazism.

When he wrote these words, in the middle of the 1960s, a Holocaust Memorial in the heart of Berlin was simply unthinkable. In Levis writings, memory never appears as a Hegelian overcoming of the contradictions of history; its function is cognitive, not allowing repair or reconciliation. We can learn from history, but the past cannot be redeemed. At best, recollections could fulfill a therapeutic function, as for writing If This Is a Man, an act he experienced as the equivalent of Freuds divan. In short, Levis claim of the duty of memory has been consecrated in our age of obsession for the past, but it was conceived of in a time of collective amnesia. The duty of memory is not a timeless and universal principle; it needs to be understood historically.

Memory of the offense means facing some fundamental ethical issues, notably that of guilt both individual and collective and pardon. In the 1960s, historicizing National Socialism meant first of all turning the page or, according to the conventional formula, Bewltigung der Vergangenheit (coming to terms with the past). Amry sarcastically evoked this formula in the subtitle of his essay, Bewltigungsversuche eines berwltigten (Overcoming attempts by an overwhelmed). Reconciliation was an empty word if it did not mean the resentment of the victims on the one hand and, on the other hand, the self-mistrust (Selbstmisstrauen) of the offenders. Such a recognition of historical responsibility, inescapable even for the generation that came after the war, was the only premise for remaking history that is, metaphorically turning back time and moralizing it (Moralisierung der Geschichte).

Levi did not express a similar resentment. His obstinate trust in the virtues of human reason was the deepest source of his anthropological optimism. To my short and tragic experience of being deported, he wrote in 1976, another one, more complex and longer, was superposed, that of writer and witness. The result was clearly positive, because such a past enriched and consolidated me. . . . Living, writing and meditating on my experience I have learnt a lot about men and their world. Amry did not share this view and accused Levi of being a forgiver (Vergeber). Levi denied the allegation, but at the same time confessed that he could not share the Austrian-Belgian writers resentment.

In the last pages of The Truce, Levi described the Germans he saw in Munich in October 1945 as a mass of insolvent debtors, and in his correspondence with Dr Ferdinand Meyer, one of the German chemists at the I. G. Farben laboratory of Buna-Monowitz in Auschwitz, he refused to pardon him: I would like to help you come to terms with your past, he wrote, but I doubt that I am able. Nevertheless, he accepted the principle of forgiveness.

To forgive and even love ones enemies is possible, he wrote, but only when they show unequivocal signs of repentance, in other words when they cease to be enemies. Curiously, Levi did not quote the best-known and most controversial book on this subject, Die Schuldfrage, by the philosopher Karl Jaspers, who had tried to distinguish different aspects of German guilt (penal, political, personal, and metaphysical guilt). Like the German philosopher, however, he raised the problem of our historical responsibility for the past.

In short, Levi could not forgive his persecutors but did not share Amrys resentment. Both of them recognized that they had been incapable of expressing joy when they were liberated from Auschwitz. But after this common admission, their paths diverged. According to Amry, Auschwitzs violence had broken human beings faculty to communicate, making them strangers to the world. Levi, on the contrary, could still see, among the skeletal figures of the death camps, a remote possibility of good.

These debates of the postwar years on guilt and victimhood belong to a finished time, when the past legacy heavily burdened the present. Today, the civil religion of the Holocaust tends to depoliticize memory, focusing on innocent victims as objects of compassion. It has emerged from a radical break with anti-fascist memory, which focused on the celebration of fallen fighters rather than victims. Nor is it by accident that the rise of the Holocaust memory has corresponded with the decline of anti-fascist memory. In many of his writings, Levi distinguished between Jewish and political deportation. In his eyes, this difference should not be hidden or diminished, but neither should it be stressed as a dividing line. He had been deported as a Jew, but had been arrested as a partisan, and when he wrote If This Is a Manafter coming back to Turin, he decided to publish some chapters in a small magazine of Piedmontese Resistance: LAmico del popolo. In his view, Jewish and anti-fascist memories could only exist together, as twin memories.

In 1978, Levi wrote a short text for the Italian pavilion of the Auschwitz Museum, which is a strong defense of anti-fascism. In the last decades, this pavilion, commissioned by the National Association of Ex-Deportees and realized by a team of committed authors the architect Ludovico di Belgiojoso, the composer Luigi Nono, and the painter Mario Samon had become a realm of memory of Italian anti-fascism. But it no longer fit the current standards of public memory and was finally closed.

Anti-fascism a particular form of anti-fascism, made of a fusion of the critical Enlightenment and left-wing republicanism was the political background of Primo Levi, but he never claimed the anti-fascist rhetoric of postwar Italy. His books share little with the epic and heroic tales of a resistance struggle for national liberation. In The Drowned and the Saved, he described himself as the worst of the partisans, lacking physical courage, experience, and political education, and he emphasized that his career as a partisan had been very brief, painful, stupid and tragic: I had taken a role that was not mine.

The tragic legacy of his experience as a partisan is summarized in a handful of passages in The Periodic Table. Levi referred to an ugly secret: the execution of two of his comrades accused of betrayal something quite common in partisan warfare that burdened his consciousness and destroyed him psychologically, depriving him of the necessary resources for carrying on the struggle.

In the last years of his life, which were punctuated by repeated and deepening depressions, Levi grew obsessed with the gray zone, the area of indistinctness where the boundaries between persecutors and victims, good and evil, were blurred; an ambiguous space whose incredibly complicated internal structure hindered the faculty of judgment. It was in this period that he depicted the Muselmann the dehumanized inmate, the embodiment of another intermediate area suspended between life and death as the complete witness of the Nazi camps. Survivors were simply vicarious representatives of these complete witnesses, who could not speak.

Levi remained a melancholic enlightener, but his optimism had disappeared. He bore testimony without considering himself a true witness, and defended anti-fascism in spite of portraying himself as a pitiful partisan. In short, he believed in the necessary search for truth, but he never preached truths; he rather tried to excavate them, to problematize them, by both recognizing their contradictions and exploring their darkest shadows.

This critical skepticism did not spare his Jewish identity and his role as a witness. In 1967, he took a position in defense of Israel, which he felt was threatened with destruction, defining it, in several interviews, as his second homeland. In 1982, at the moment of the Israeli invasion of Lebanon and the massacre of Sabra and Shatila, he denounced this aggression and warned against the birth of a paradoxical form of Israeli fascism embodied by leaders such as Menachem Begin, whom he stigmatized as a disciple of Zeev Jabotinsky, an admirer of Mussolini. He knew that many of the founders of Israel had been people who, like him, had survived the Holocaust, but could not come back to their homes. This was a matter of fact, but it did not immunize them nor Israel against fascism. This was another dimension of the gray zone.

In an interview in 1983, Primo Levi admitted his exhaustion. He no longer wished to meet pupils and students who repeated the same questions, but he also added that he was not satisfied by his own answers. He described having been deeply unsettled by a question asked by two adolescents in a school: Why do you still come to tell us your story, forty years later, after Vietnam, the Stalin camps and Cambodia, after all this Why? He remained in front of them, voiceless, mouth agape, as a witness retreating back into himself. His convictions, his pedagogical talents and rhetorical skills, his long career of witnessing suddenly seemed useless in front of this simple question. He felt overwhelmed by shame, the human shame he had discovered in Auschwitz and which he met again translating Franz Kafkas The Trial. The past is an inexhaustible receptacle of materials for literary creation, but, unfortunately, history is not a magistra vitae.

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Most differences in DNA binding compounds found at birth in children conceived by IVF not seen in early childhood – National Institutes of Health

Posted: at 6:39 am

News Release

Wednesday, April 14, 2021

NIH study results bolster previous studies finding no growth, development differences with IVF.

Compared to newborns conceived traditionally, newborns conceived through in vitro fertilization (IVF) are more likely to have certain chemical modifications to their DNA, according to a study by researchers at the National Institutes of Health. The changes involve DNA methylation the binding of compounds known as methyl groups to DNA which can alter gene activity. Only one of the modifications was seen by the time the children were 9 years old.

The study was conducted by Edwina Yeung, Ph.D., and colleagues in NIHs Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). Previous studies by the research team found no differences in growth and development for this group.

Our study found only small differences in DNA methylation at birth and these were not seen in early childhood, Dr. Yeung said. When considered along with our previous studies finding no differences in childrens growth and development, our current study should be reassuring to couples who have conceived with fertility treatments and to those considering these methods.

IVF consists of collecting eggs and sperm, fertilizing the eggs in a lab, and then transferring the resulting embryo or embryos into the uterus. Another technique, intracytoplasmic sperm injection (ICSI), consists of injecting a sperm cell directly into the egg before placing the resulting embryo into the uterus.

Methylation changes were not associated with two other fertility treatments, ovulation induction (drug treatment to release the egg from the ovary) and intrauterine insemination (insertion of semen directly into the uterus).

According to a national report in 2018, almost 75,000 IVF-conceived infants (2.0% of all infants) were born in the United States. Of these, approximately 76% were conceived with ICSI. Another study found that 3 to 7% of births resulted from ovulation induction and intrauterine insemination.

When methyl groups are added to a gene, the gene is switched off and does not produce a protein. Methyl groups are added and removed from DNA throughout life, as genes are alternately switched on and off. Changes in methylation may occur in any step of IVF. These include exposure to hormones needed to bring the eggs to maturity so they can be collected or exposure to the culture medium in which the eggs are fertilized and embryos develop.

Previous studies have found associations between IVF and certain rare disorders. However, many of these studies were small and their results inconsistent. Also, many of the studies were conducted before ICSI was in widespread use.

For the current study, researchers evaluated data on DNA methylation differences in children beginning at birth and when they were 8 to 10 years old. The children were born in New York State from 2008 to 2010 and more than 70% of IVF birth were with ICSI.

Of the newborns, 157 were conceived with fertility treatments and 520 were conceived without treatments. Newborns conceived with IVF were more likely to have lower methylation levels in some parts of their DNA. The researchers did not find any methylation changes for newborns conceived by ovulation induction or intrauterine insemination.

Among the 152 children who provided DNA samples at 8 to 10 years old, 23 were conceived with IVF and 34 with ovulation induction or intrauterine insemination. For children conceived with IVF, lower methylation levels were seen for only one region, in the GNAS gene, which has been found in some previous studies but not others.

The study authors called for more research on how variations in fertility treatments could contribute to methylation differences in children, such as variations in the medium used to culture embryos.

About the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD): NICHD leads research and training to understand human development, improve reproductive health, enhance the lives of children and adolescents, and optimize abilities for all. For more information, visit https://www.nichd.nih.gov.

About the National Institutes of Health (NIH):NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.

NIHTurning Discovery Into Health

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Police say DNA connects suspect to a string of smash and grabs in Danville – Fox 59

Posted: at 6:39 am

DANVILLE, Ind. Danville Police credit DNA for connecting a suspect to a smash and grab crime spree.

Back in October, a husband and wife were out walking near Twin Bridges Trails. When the couple returned to their car, they found the car window busted and the womans purse was gone.

Its not like we forget about the case. We are still going to come after you, said Nate Lien, detective with Danville Police Department.

Now months later, Danville Police believe Donald Cates is the man behind the crime.

We know in our case its solid, said Detective Lien.

Lien tells FOX 59 that when Cates busted the car window, he cut himself, leaving behind his DNA. Investigators waited for the lab results to come back and got a match.

Theres no fighting that your blood is on their broken window and their stuff is stolen there. So, its one of the pieces to the puzzle that is vital to solving this case, said Detective Lien.

Police are confident the smash and grab that happened in the Danville parking lot wasnt the first for Cates. So far, hes under investigation for possibly doing the same thing at other trails in several surrounding counties. The DNR is looking into him too.

He was specifically targeting trailheads and parks, where cars are left unattendedand people are out walking and away from their cars, said Detective Lien.

Detective Lien says investigators from Hamilton County, Pendleton, and New Castle have all been working together and comparing surveillance pictures from when the suspect used stolen credit cards from vehicles.

This was the suspect in every one of the cases. Basically, weve caught him at once, said Detective Lien.

Detectives are warning criminals, no matter how much time goes by cases remain open and clues, even the ones they unknowingly left behind are helping investigators close in on them.

Theres DNA on everything. Theres DNA in saliva, hair, people dropping cigarettes. We use DNA all the time it might take a awhile but eventually youre going to get caught, said Detectives Lien.

Cates has been charged with theft, felony theft due to prior convictions, fraud, criminal mischief among other charges.

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No, the COVID-19 vaccine will not change your DNA – MLive.com

Posted: at 6:39 am

The COVID-19 vaccine wont change your DNA.

None of the three vaccines between Pfizer, Moderna or Johnson & Johnson actually enter the nuclei in a persons cell, according to the CDC, meaning none of them actually interact with DNA or a genome.

The Pfizer-BioNTech and Moderna vaccines are mRNA vaccines, which teach our cells how to make a protein that triggers an immune response, according to the CDC. The mRNA from a COVID-19 vaccine never enters the nucleus of the cell, which is where our DNA is kept. This means the mRNA cannot affect or interact with our DNA in any way.

Regarding the Johnson & Johnson shot, the material it delivers to a persons cells does not integrate into a persons DNA, the CDC states. The Johnson & Johnson vaccine was temporarily halted in Michigan following guidance from federal regulators after six people nationwide reported rare, but serious blood clots.

Infectious disease and biology experts however said none of the vaccines access or change DNA, refuting a series of conspiracy theories circling around social media.

The concern over DNA alteration was perhaps most prominently voiced in an April 8 article in The Defender, a publication run by the anti-vaccination group Childrens Health Defense. The post cited a preprinted research paper from Harvard and MIT scientists that asserts that mRNA from the virus can very rarely persist in an individuals body tissue even after infection.

Richard Young, a co-author on the paper and an MIT professor of biology, told MLive its terrible his teams research is being used in anti-vax circles, since his teams findings only address the COVID-19 virus and not any of the vaccines.

It is possible that the (COVID-19) virus might integrate on a rare instance into a human genome into tissue culture itself, Young said. But the vaccine is just a tiny piece of spike protein in an mRNA molecule. So when the vaccine mRNA goes into the cell, it only goes into the cytoplasm where it can be made into proteins by ribosomes. So it doesnt even go into the nucleus.

Spike proteins, according to the CDC, trigger our immune system cells to recognize the COVID-19 virus and begin producing antibodies to fight the infection.

Young said he and his colleagues research should be seen as more reason to avoid natural COVID-19 infection, not to avoid the vaccine. Compared to the virus, the vaccine carries less than 1% of the molecules used to replicate viral mRNA that can lead to very rare genetic alteration, Young said.

If you were weighing a concern, Id be very concerned about being infected with the virus, he said, because the virus is giving some people long COVID, whereas the vaccine doesnt seem to be hurting anyone.

Read more: Long Covid continues to stump doctors and exhaust those fighting months-long battles

While the Johnson and Johnson vaccine works differently than its counterparts, it accomplishes the same goal of creating proteins to catalyze the creation of antibodies, said Dr. Anthony Ognjan, infection disease doctor with MacLaren Macomb hospital.

Its called a viral vector vaccine, he said. Similar to AstraZeneca, what it does is it takes the virus and creates a kind of infection in people, but not really...it attaches spike proteins to the virus, the viruses are naturally taken up by the cells and then the cells process automatically an immune reaction.

The bottom-line: the COVID-19 vaccines does not get incorporated into human DNA, Ognjan said. Vaccines that treat herpes are examples of ones that can alter DNA, but the COVID-19 shots dont follow the same method.

The genetic alteration concern picks up on a fear some people have about how changed DNA leaves some individuals susceptible to cancer down the road, Ognjan said. While altered DNA does carry those risks, that fear is being conflated with the COVID-19 vaccine in a frustrating way, he said.

People who dont understand the science, anti-vaxxers and pseudoscientists are taking advantage of peoples naivety and not understanding the basic science of whats going on, he said. You see that stuff get scattered over the internet, and it drives me crazy.

Read more from MLive:

As Michigans coronavirus cases surge, experts say its hard to pinpoint an exact cause

Whitmer on CNN: Michigan could shed COVID-19 restrictions, fully reopen this summer

Michigan hospital to study COVID-19 vaccine in people with severe allergies

COVID-19 risk from touching contaminated surface is less than 1 in 10,000, new CDC study says

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Pulsed-Field Gel Electrophoresis (PFGE) for the Separation of DNA Macromolecules – AZoM

Posted: at 6:39 am

Pulsed-field gel electrophoresis (PFGE), or clamped homogeneous electrical field electrophoresis (CHEF), is a novel gel electrophoresis type for the separation of DNA macromolecules.

This is accomplished by alternating anode and cathode at specific intervals, which means that the DNA molecules have to realign themselves in the electrical field before they can continue to progress in the matrix.

Smaller molecules orient themselves much faster than larger ones, which means that they cover a larger distance in a predetermined amount of time. The separation of the DNA molecules relies on a series of various factors: voltage, runtime, buffer concentration, temperature and how fast anode and cathode are changing.

Due to the extended runtimes of PFGE protocols and the occasional high voltage, a constant and low buffer temperature is key for the success of the method. These low temperatures and long runtimes present a unique challenge for the tubes used in a PFGE setup for the transmission of the buffer solution.

Often, standard silicone tubes are employed when running a PFGE setup, as illustrated in Fig. 1. A pump (Heidolph Hei-FLOW Value 01 peristaltic pump with SP quick 1,6 pump head; B) is affixed to the running chamber (A; Fig. 2) with about 10 m of tube material fed into a cooling unit (C).

Figure 1. Setup of the PFGE apparatus. (A) shows the gel chamber in which the running buffer is located. This buffer is continuously circulated by a pump (B). About 10 meters of silicone tubing are placed in a cooling unit (C) to keep the buffer constant at low temperature. Image Credit: Heidolph North America

Figure 2. Top view on the gel chamber, the flow direction of the buffer solution is indicated by the red arrow. Image Credit: Heidolph North America

Since the apparatus is continually used with cold buffer for up to 260 hours, it is critical to choose the appropriate tubing to avoid any complications (tearing, formation of air bubbles and loss of pumping power).

Silicone tubes wear out very fast. Therefore this test will show if they can be replaced with a more robust one.

Comparison of three tubes for peristaltic pumps will be carried out with regards to their applicability in the field of PFGE. Those tested were Heidolphs Tygon Standard, Tygon 2001 and PharMed tubes with an inner diameter of 6,4 mm and a wall thickness of 1,6 mm.

The following tests have been conducted at the laboratory of Dr. Marlis Dahl, Department of Biology, Division of Biochemistry at the Friedrich-Alexander-University Erlangen-Nuremberg.

The tubing was tested in the assembly as exhibited in figures 3 and 4, in line with the protocols shown in Table 1: Protocol A was selected due to it being the most commonly used protocol in the laboratory; Protocol B was used because it has the greatest requirement regarding the runtime.

Figure 3. Experimental setup of the PFGE apparatus, showing in which direction the buffer flows (red arrow) inside of the chamber and which tubes transport the buffer to (blue arrow) and from the cooling system (yellow arrow). Image Credit: Heidolph North America

Figure 4. The connected pump with the PharMed tubing. Also shown is the flow or pump direction of the running buffer. Image Credit: Heidolph North America

Table 1. Test protocols for the examination of the tubes. Source: Heidolph North America

After the protocols, the tubing was evaluatedand it was decided if any changes were necessary.

The Tygon 2001 tubing turned out unsuitable for the intended purpose due to it being too rigid.

Already demonstrating undesirable effects in the shorter test following Protocol A: although bubble accumulation was mitigated during the day, the next morning, numerous large bubbles were found to impede pumping (that is, insufficient cooling of the gel).

Moreover, the tube appeared to be rather brittle in the area inside the pump head. The Tygon Standard tubing facilitated good buffer circulation for a slightly longer period of time, but after some use, it cracked.

This could be a result of the low temperature of the buffer, which makes the tubing less flexible and eventually leads to breakage. The PharMed tubing performed best.

Although the part of the tubing inside the pump head stretched after an extended period of use, demonstrating that the material was thinning, it still lasts much longer than a common silicone tubing.

The latter can be fitted in the same way, but wear is significantly greater, which means that the part of the tube inside the pump head must regularly move. Otherwise, tearing will occur.

These tests demonstrated that replacing conventional silicone tubing can be achieved with the longer lasting PharMed tubing for a pulsed-field gel electrophoresis assembly using the Hei-FLOW Value 01 peristaltic pump with the SP quick 1.6 pump head.

The Tygon 2001 and Tygon Standard tubing were proven to be inappropriate for the PFGE process.

Image Credit: Heidolph North America

This information has been sourced, reviewed and adapted from materials provided by Heidolph North America.

For more information on this source, please visit Heidolph North America.

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DNA Methylation Market Value Anticipated To Reach US$ 2,726.2 Million By 2027: Acumen Research and Consulting – GlobeNewswire

Posted: at 6:39 am

LOS ANGELES, April 12, 2021 (GLOBE NEWSWIRE) -- The Global DNA Methylation Market is expected to grow at a CAGR of around 13.2 % from 2020 to 2027 and reach the market value of over US$ 2,726.2 Mn by 2027.

North America holds the largest market share for the global DNA methylation market

The rapid developments in healthcare infrastructure, the presence of prominent players in this region, and massive R&D investments, North America dominates the DNA methylation market. With increased investment in product and industry R&D, demand for protein expression systems is expected to raise, as many mammalian proteins, including growth hormone, insulin, antibodies, and vaccines, are produced on a large scale. Biopharmaceutical sales have recently surpassed 30% of all new pharmaceutical sales in the country. The United States is the world's largest spender on healthcare research. All of these factors contribute to the expansion of the global DNA methylation market.

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Market Dynamics

DNA methylation in metabolic diseases, oncology, and immunology flourish the growth of global market

Oncology is one of the fields in which DNA methylation technology is widely used to develop therapeutic strategies aimed at reversing the transcriptional abnormalities inherent in the cancer epigenome. This disruption of epigenetic modifications, which include DNA methylation and histone modification, leads to changes in gene function or expression as well as cellular transformation, which leads to cancer. DNA methylation aids in the development of inhibitors of DNA methyltransferases and histone deacetylases (HDACs), which have been shown to be clinically effective in cancer treatment, demonstrating the importance of DNA methylation technology in oncology.

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Segmental Outlook

The global DNA methylation market is segmented based on product, application, technology, and end-user. By product, the market is segmented as enzymes, instruments and consumables, kits, reagents, and bioinformatics tools. Enzymes are further sub segmented into DNA-modifying enzymes, protein-modifying enzymes, and RNA-modifying enzymes. Further, instruments and consumables are sub segmented as next-generation sequencers, qPCR, mass spectrometers, sonicators, and others. Kits is further sub segmented as bisulfite conversion kits, ChIP-sequencing kits, RNA sequencing kits, whole genomic amplification kits, 5-hmC and 5-mC analysis kits, and others. Reagents are further sub segmented as antibodies, buffers, histones, magnetic beads, primers, and among others.

By application, the market is segmented as oncology, metabolic diseases, developmental biology, immunology, cardiovascular diseases, and others. Based on application, the market is segmented as oncology, metabolic diseases, immunology, and others. Based on technology, the market is segregated as DNA methylation, histone modifications, and others. By end-user, the market is segmented as academic and research institutes, pharmaceutical and biotechnology companies, and contract research organizations (CROs)

Competitive Landscape

Key companies profiled in this report involve Illumina, Inc., Merck Millipore, Abcam plc, Active Motif, Bio-Rad Laboratories, Inc., New England Biolabs, Agilent Technologies, Inc., QIAGEN, Zymo Research, PerkinElmer, Inc., Diagenode, and among others.

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Some of the key observations regarding DNA methylation industry include:

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DNA Methylation Market Value Anticipated To Reach US$ 2,726.2 Million By 2027: Acumen Research and Consulting - GlobeNewswire

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DNA Exclusive: COVID-19 surge, waiting list, and the eternal reality of death – Zee News

Posted: at 6:38 am

New Delhi: The COVID-19 pandemic situation has become very serious in the country. It has taken many lives, destroyed many families. Due to sheer negligence, thousands of people are at the risk of facing death.

One who has conquered destiny is called Muqaddar Ka Sikandar. Today, those who manage to keep themselves alive in these trying times can be certainly called that.

Zee News Editor-in-Chief Sudhir Chaudhary on Wednesday (April 14) discussed the deteriorating situation in the country due to COVID-19 surge which has forced even the dead to wait in line.

It is said that life is fleeting and that it ends in an instant. Death is the absolute truth. No human can escape that fate. But the pandemic has made life look really cheap.

An average Indian spends about 10 years of their life standing in queue. The first queue begins right at birth to obtain a certificate for the same. Then comes the numerous queues such as that for school admission, jobs, rations, bank etc. Now even death has forced humans to wait in the queue.

The number of patients getting infected with the coronavirus in India is increasing rapidly. In the last 24 hours 1.84 lakh cases have been registered. There have been 1027 deaths in the same period.

This surge is quite worrying and in many cities across the country, the crematoriums are running out of capacity.

In Bhopal, so many corpses are coming in every day that now there is a shortage of wood to carry out cremation of the dead.

In Rajkot, people have to wait for over 30 hours for the last rites. Similar reports have come in from Surat, where the cremation ghats are running out of space to store the dead bodies that are waiting to be cremated.

In Bharuch, several bodies were cremated together and in many cases, people werent able to attend the last rites of their loved ones.

In Ranchi, 12 bodies had to wait for over a day to be cremated.

Similar scenes were observed in Lucknow, Rajkot, Delhi, Nanded, Durg and other places, where the dead had to wait in a long queue just get cremated.

In Hinduism, Antim Sanskar is the final ritual of the 16 sanskars and it is said that it should be performed after sunset. But coronavirus has forced to change these traditions as pyres are burning every hour at the crematoriums.

The situation is so bad that a person would be considered fortunate to be cremated within hours of their death.

In general, no one likes to talk about death. But the coronavirus has made it a usual discussion among people. Such is the crisis the country is facing today.

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DNA Exclusive: COVID-19 surge, waiting list, and the eternal reality of death - Zee News

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