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Monthly Archives: April 2021
INOVIO’s COVID-19 Vaccine Candidate, INO-4800, Provides Broad Cross-reactive Immune Responses In Humans Against Variants of Concern – BioSpace
Posted: April 17, 2021 at 12:06 pm
PLYMOUTH MEETING, Pa., April 15, 2021 /PRNewswire/ --Inovio (NASDAQ:INO), a biotechnology company focused on rapidly bringing to market precisely designed DNA medicines to treat and protect people from infectious diseases, and cancer, today announced the results of a study focusing on the human immune responses induced by INOVIO's DNA vaccine candidate for COVID-19, INO-4800, against variants of concern. The results showed that INO-4800 induced a robust T cell response against all spike protein variants tested, which the company believes will be key in providing protection against SARS-CoV-2 variants, in addition to providing similar levels of neutralizing activity against both the UK and Brazilian variants as those against the original strain. The study, entitled "INO-4800 DNA Vaccine Induces Neutralizing Antibodies and T cell Activity Against Global SARS-CoV-2 Variants," has been submitted for peer review and can be viewed at https://www.biorxiv.org/content/10.1101/2021.04.14.439719v1.
Dr. J. Joseph Kim, INOVIO's President & CEO, said, "These results are consistent with our expectation that INO-4800, which was found to be well-tolerated and able to produce a balanced immune response in our Phase 1 trial, is able to generate both neutralizing antibodies and robust T cell responses both of which will be essential to protect against the emerging variants of concern."
Regarding INO-4800 development Dr. Kim said, "We will report Phase 2 results in 2Q, and, with FDA concurrence, expect to move into Phase 3 in the second quarter of this year. Our COVID vaccine's projected safety profile, its stability at room temperature for more than a year, and likely ability to safely boost numerous times positions INOVIO's COVID-19 vaccine as an important factor in addressing the virus in its pandemic and endemic states."
In the study, clinical samples were collected at varying timepoints post-immunization from subjects in INOVIO's Phase 1 US-based INO-4800 clinical trial. Antibodies capable of neutralizing activity were measured against the spike protein variants tested, including B.1.1.7 (UK variant), B.1.351 (South African variant) and P.1. (Brazilian variant). The study showed the T cell responses induced by INO-4800 vaccination were fully maintained against the UK, South African and Brazilian variants when compared to the T cell responses to the original Wuhan strain. The neutralization levels of INO-4800 against South Africa and UK variants were reduced to the levels similar to the previous reports of mRNA or viral vector vaccines. Furthermore, despite recent reports showing a reduction in neutralizing activity against the Brazilian variant by the mRNA or viral vector vaccines, INO-4800 generated robust neutralizing antibodies at levels against Brazilian variant which were comparable to those against the Wuhan strain. Taken together with the data showing the maintenance of T cell activity, the results reported in this study provide a comprehensive overview of cross-reactive cellular and humoral immune responses against SARS-CoV-2 variants for INO-4800 vaccinated individuals that may be important for protection against variant strains of SARS-CoV-2.
Collectively, the studies showcase how the combination of robust T cell responses in conjunction with neutralizing antibody responses provide an important defense against both emerging and potential future viral variants, exhibiting broad protection against the virus and less impacted by the mutational changes a virus may undergo.
About INO-4800
INO-4800 is INOVIO's DNA vaccine candidate against SARS-CoV-2, the novel coronavirus that causes COVID-19. Composed of an optimized DNA plasmid, INO-4800 is delivered directly into cells in the body via a proprietary smart device to produce a robust and tolerable immune response. INO-4800 is the only nucleic-acid based vaccine that is stable at room temperature for more than a year, at 37o C for more than a month, has a five-year projected shelf life at normal refrigeration temperature and does not need to be frozen during transport or storage all of which are important considerations when preparing for mass immunizations.
About INOVIO's DNA Medicines Platform
INOVIO has 15 DNA medicine clinical programs currently in development focused on infectious diseases, cancer and HPV-associated diseases. DNA medicines are composed of optimized DNA plasmids, which are small circles of double-stranded DNA that are synthesized or reorganized by a computer sequencing technology and designed to produce a specific immune response in the body.
INOVIO's DNA medicines deliver optimized plasmids directly into cells intramuscularly or intradermally using INOVIO's proprietary hand-held smart device called CELLECTRA. The CELLECTRA uses a brief electrical pulse to reversibly open small pores in the cell to allow the plasmids to enter, overcoming a key limitation of other DNA and nucleic acid approaches, such as mRNA. Once inside the cell, the DNA plasmids enable the cell to produce the targeted antigen, which is processed naturally in the cell and triggers the desired T cell and antibody-mediated immune responses. INOVIO's DNA medicines do not interfere with or change in any way an individual's own DNA. The advantages of INOVIO's DNA medicine platform are how fast DNA medicines can be designed and manufactured; the stability of the products, which do not require cold storage or transport; and the robust immune response, safety profile, and tolerability that have been observed in clinical trials.
With more than 3,000 patients receiving INOVIO investigational DNA medicines in more than 7,000 applications across a range of clinical trials, INOVIO has a strong track record of rapidly generating DNA medicine candidates with potential to meet urgent global health needs.
About INOVIO
INOVIO is a biotechnology company focused on rapidly bringing to market precisely designed DNA medicines to treat and protect people from infectious diseases, cancer, and diseases associated with HPV. INOVIO is the first and only company to have clinically demonstrated that a DNA medicine can be delivered directly into cells in the body via a proprietary smart device to produce a robust and tolerable immune response. Specifically, INOVIO's lead candidate VGX-3100 met primary and secondary endpoints for all evaluable subjects in REVEAL 1, in the first of two Phase 3 trials for precancerous cervical dysplasia, demonstrating ability to destroy and clear both high-grade cervical lesions and the underlying high-risk HPV 16 and 18. INOVIO is also evaluating INO-4800, a DNA vaccine candidate against COVID-19, in a Phase 2 clinical trial in the U.S., as well as Phase 2 trials in China and South Korea. Partners and collaborators include Advaccine, ApolloBio Corporation, AstraZeneca, The Bill & Melinda Gates Foundation, Coalition for Epidemic Preparedness Innovations (CEPI), Defense Advanced Research Projects Agency (DARPA)/Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense (JPEO-CBRND)/Department of Defense (DOD), HIV Vaccines Trial Network, International Vaccine Institute (IVI), Kaneka Eurogentec, Medical CBRN Defense Consortium (MCDC), National Cancer Institute, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Ology Bioservices, the Parker Institute for Cancer Immunotherapy, Plumbline Life Sciences, Regeneron, Richter-Helm BioLogics, Thermo Fisher Scientific, University of Pennsylvania, Walter Reed Army Institute of Research, and The Wistar Institute. For more information, visit http://www.inovio.com.
CONTACTS:
Media: Jeff Richardson, 267-440-4211, jrichardson@inovio.comInvestors: Ben Matone, 484-362-0076, ben.matone@inovio.com
This press release contains certain forward-looking statements relating to our business, including our plans to develop DNA medicines and in particular our clinical work relating to INO-4800 and its potential effectiveness against SARS-CoV-2 variants, our expectations regarding our research and development programs, including the planned initiation and conduct of preclinical studies and clinical trials and the availability and timing of data from those studies and trials, and our ability to successfully manufacture and produce large quantities of our product candidates if they receive regulatory approval. Actual events or results may differ from the expectations set forth herein as a result of a number of factors, including uncertainties inherent in pre-clinical studies, clinical trials, product development programs and commercialization activities and outcomes, our ability to secure sufficient manufacturing capacity to mass produce our product candidates, the availability of funding to support continuing research and studies in an effort to prove safety and efficacy of electroporation technology as a delivery mechanism or develop viable DNA medicines, our ability to support our pipeline of DNA medicine products, the ability of our collaborators to attain development and commercial milestones for products we license and product sales that will enable us to receive future payments and royalties, the adequacy of our capital resources, the availability or potential availability of alternative therapies or treatments for the conditions targeted by us or our collaborators, including alternatives that may be more efficacious or cost effective than any therapy or treatment that we and our collaborators hope to develop, issues involving product liability, issues involving patents and whether they or licenses to them will provide us with meaningful protection from others using the covered technologies, whether such proprietary rights are enforceable or defensible or infringe or allegedly infringe on rights of others or can withstand claims of invalidity and whether we can finance or devote other significant resources that may be necessary to prosecute, protect or defend them, the level of corporate expenditures, assessments of our technology by potential corporate or other partners or collaborators, capital market conditions, the impact of government healthcare proposals and other factors set forth in our Annual Report on Form 10-K for the year ended December 31, 2020, and other filings we make from time to time with the Securities and Exchange Commission. There can be no assurance that any product candidate in our pipeline will be successfully developed, manufactured or commercialized, that final results of clinical trials will be supportive of regulatory approvals required to market products, or that any of the forward-looking information provided herein will be proven accurate. Forward-looking statements speak only as of the date of this release, and we undertake no obligation to update or revise these statements, except as may be required by law.
View original content:http://www.prnewswire.com/news-releases/inovios-covid-19-vaccine-candidate-ino-4800-provides-broad-cross-reactive-immune-responses-in-humans-against-variants-of-concern-301269572.html
SOURCE INOVIO Pharmaceuticals, Inc.
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SpaceX agrees to steer Starlink internet satellites clear of space station, NASA spacecraft – Space.com
Posted: at 12:05 pm
SpaceX recently inked a deal with NASA to move any of the company's Starlink internet satellites out of the way if they stray too close to the International Space Station or other agency spacecraft.
The Space Act Agreement, which was signed on March 18, will help maintain and improve space safety, NASA officials said.
SpaceX has launched more than 1,400 of its Starlink broadband satellites to orbit to date. Following the first operational Starlink launch in 2019, the company has tweaked the satellites' design, providing upgrades intended to reduce their reflectivity, enable them to communicate with each other on orbit and even maneuver out of the way if necessary.
Related: SpaceX's Starlink satellite megaconstellation launches in photos
"With commercial companies launching more and more satellites, its critical we increase communications, exchange data and establish best practices to ensure we all maintain a safe space environment," Steve Jurczyk, NASA's acting administrator, said in a statement.
In 2020, the International Space Station had to adjust its orbit multiple times to avoid potential collisions, a task that takes some coordinated effort. As the number of Starlink and other satellites in orbit increases, so does the likelihood that some type of space-traffic incident could occur.
SpaceX has long stressed that its Starlink satellites are equipped with autonomous collision-avoidance features that help the craft change positions in orbit. By signing this new agreement, NASA is hopeful that if such a close pass should occur, only the Starlink spacecraft will have to move.
The agreement also requires SpaceX to notify NASA at least a week before each Starlink launch so the agency can determine if that mission poses any collision-avoidance issues. To go one step further, SpaceX has agreed to launch its satellites into initial orbits that do not come within 3 miles (5 kilometers) of the ISS or other NASA spacecraft.
"NASA has agreed to not maneuver in the event of a potential conjunction to ensure the parties do not inadvertently maneuver into one another," the agreement states. "NASA will operate on the basis that the autonomous maneuvering capability of the Starlink satellites will attempt to maneuver to avoid conjunction with NASA assets, and that NASA will maintain its planned trajectory unless otherwise informed by SpaceX."
Additionally, the collaboration with SpaceX will include work to further reduce the brightness of the Starlink satellites. To date, SpaceX has outfitted its Starlink satellites with a special sun visor that reduces the spacecraft's brightness, but the agreement allows for the sharing of information between the two entities.
SpaceX is not the only company with big plans for space-based internet service. OneWeb, Telstar and Amazon all have their own constellations planned. In a real-world example of why these types of agreements exist, a Starlink spacecraft and a OneWeb satellite zoomed uncomfortably close to each other on March 30.
The two companies were able to coordinate, with OneWeb moving its satellite out of the way. As the number of satellites in space increases rapidly, such cooperation will likely be key to avoiding collisions.
Follow Amy Thompson on Twitter @astrogingersnap. Follow us on Twitter @Spacedotcom or Facebook.
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SpaceX agrees to steer Starlink internet satellites clear of space station, NASA spacecraft - Space.com
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Boeings Starliner Is Further Delayed Due to ISS Traffic Jam Created by SpaceX – Observer
Posted: at 12:05 pm
SpaceX has already proved that its better at building human-carrying spacecraft than Boeing. Now its busy operation schedule is actually hampering Boeings effort to catch up. SpaceX has so many missions scheduled to arrive at the International Space Station in the coming months that there are no docking ports available for Boeing to conduct test flights with.
SpaceX and Boeing are both contractors under NASAs Commercial Crew Program, tasked with building a reusable rocket-spacecraft system for transporting astronauts and payloads to the ISS. SpaceXs system consists of its workhorse Falcon 9 booster and a new capsule called Dragon, and Boeing is building a capsule called Starliner to be launched atop a United Launch Alliance Atlas V rocket.
SpaceX delivered the Dragon capsule last May and has successfully flown six astronauts to the space station through two missions. Boeing, by contrast, is still struggling to lift Starliner off the ground.
A key upcoming test is to launch an uncrewed CST-100 Starliner capsule to the ISS, have it docked at one of the stations ports for a week, and fly it back to Earth. The test, called OFT-2, was scheduled for this month. But Boeing may have to push it back to July or August due to a traffic jam near the ISSs docking ports in the coming weeks.
Boeings Starliner has to been docked at a port with an international docking adapter. There are only two such ports on the space station. One of them is currently occupied by the Dragon capsule used in SpaceXs Crew-1 mission, launched last November. The other port will be occupied by another Dragon capsule on April 22 when SpaceX launches its Crew-2 mission carrying four astronauts. The Crew-2 vehicle will remain attached to the space station for six months. And soon after Crew-1 returns to Earth on April 28, a SpaceX cargo mission is set to launch on June 3 occupy the vacated port until mid-July.
That leaves Boeing about a one-month window in May to conduct the Starliner test. Otherwise, it will have to wait till July.
A May launch seems unlikely, since Boeing hasnt provided any updates on the test since early March.Two NASA sources told Ars Technica that Starliner is close to being ready, with only a few small tests remaining to certify the spacecraft for flight.
Based on the current traffic at the space station, NASA does not anticipate that OFT-2 can be accomplished later in April. NASA and Boeing are working to find the earliest possible launch date, Boeing said in a statement dated March 4.
Boeings last attempt to test Starliner was in December 2019. An uncrewed Starliner failed to reach the ISS and returned to Earth in a shortened test flight.
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Boeings Starliner Is Further Delayed Due to ISS Traffic Jam Created by SpaceX - Observer
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NASA Shares Breathtaking Image Of Our Milky Way Galaxy Captured From The International Space Station! – Mashable India
Posted: at 12:05 pm
NASA just shared a breathtaking image of a milky way galaxy captured from the International Space Station (ISS) on its official Instagram page. Ever since its posting, the image has received over 9 lakh likes and 3000 comments.
See Pic: NASAs Perseverance Rover And Mars Ingenuity Helicopter Just Captured Their First Ever Selfie Together!
The caption for the image that has left netizens completely awestruck states, Our next photo needs no introduction. We could stare for hours. Shown here, we see our Milky Way galaxy captured from the International Space Station (@ISS) from the @SpaceX Crew Dragons eye by @JAXAJP astronaut Soichi Noguchi. The luminous horizon of the Earth dominates the image along with thousands of brilliant specks of stars. Check it out:
NASA also highlighted an exciting fact about the stars, stating that they are arranged in "a pinwheel pattern with four major arms", and we live in one of them, about two-thirds of the way outward from the centre of the Milky Way. In fact, our Solar System is located at about 25,000 light-years away from the centre of our galaxy, meaning that we live in the suburbs of our galaxy! How cool! Also, it takes 250 million years for our Sun and the solar system to go all the way around the centre of the Milky Way.
For the uninitiated, A large group of stars, gas, and dust bound together by gravity is referred to as a galaxy. All the stars that you can spot in the bright sky are in our milky way galaxy, explains NASA. The sun and all the planets around it are considered part of a galaxy known as the Milky Way Galaxy.
SEE ALSO: NASA Hubble Telescope Captures A Beautiful Evil Eye Galaxy In The Sky!
Now, in case youre wondering why our galaxy is called the Milky Way galaxy, thats because it can be seen as a milky band of light in the sky when you observe it in a really dark area.
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Webinar: Collaborative Robotics 2021 New Systems, Applications and Opportunities – April 21 – Robotics Business Review
Posted: at 12:04 pm
Whats new for collaborative robotics systems, enabling technologies and applications? Whats next? Attend this online session on April 21st to find out.
By RBR Staff | April 16, 2021
Listen to this article
Wednesday, March 24, 20212 PM ET / 11AM PT
The introduction of collaborative robots, robotic systems that can work safely in close approximation with human co-workers, has increased task flexibility and expanded the number and types of applications for which robots can be used. Both large, existing robotics suppliers, as well as new, smaller firms, have rapidly introduced innovative collaborative robotics technologies into the market, and more are on their way. Unfortunately, this fast-moving sector makes for uncertainty for both end-users and developers of collaborative systems.
This webinar will act to increase clarity, providing a snapshot of the current state of the collaborative robotics sector, including emerging capabilities, new applications and business models, and powerful enabling technologies, as well as a description of what to expect in the future. Topics include:
Date / Time Wednesday, April 21, 2021 2 PM ET / 11 AM PT
Sponsored by:
Dan Kara, Vice President, Robotics, WTWH Media
Dan Kara is Vice President, Robotics at WTWH Media where he chartered with driving the companys robotics initiatives including the Robot Report and Robotics Business Review online portals and the Robotics Summit Conference and Exposition, Healthcare Robotics Engineering Forum, RoboBusiness Conference & Expo and the International Field Robotics Engineering Forum. Prior to joining WTWH, he was Practice Director, Robotics and Intelligent Systems at ABI Research and Chief Research Officer for Myria RAS, both research and advisory services firms focused on automation, robotics and intelligent systems. Dan was also President of Robotics Trends, an integrated media and research firm serving the personal, service and industrial robotics markets. Dan has also worked as Executive Vice President of Intermedia Group, and Director of Research at Ullo International.
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Biomedical Engineer Receives Grant to Further His Research into Using Robotics for Cancer Detection and Monitoring – WPI News
Posted: at 12:04 pm
Haichong (Kai) Zhang, assistant professor of Robotics Engineering and Biomedical Engineering, has received a $445,742, five-year grant to continue his ongoing research into creating robotic systems to use minimally invasive technologies to safely and accurately detect and monitor cancer.
Zhangs grant is part of a larger project funded by the National Institutes of Health (NIH) and led by Martin Pomper, director of Nuclear Medicine and Molecular Imaging and professor of Radiology and Radiological Science at Johns Hopkins University. Pomper received a total of $2,266,703 for his work to create an innovative, targeted chemical compound that can be used during imaging to enable better detection and treatment of aggressive forms of cancer. Zhang, a co-investigator on the project and a subcontractor on the award, will focus on designing and creating a photoacoustic imaging apparatus, which will be part of his diagnostic imaging robot, to evaluate the chemical contrast agents that Pompers team synthesizes.
Creating a diagnostic imaging robot has been an ongoing project for Zhang. In 2019, he received a five-year $1,869,423 Director's Early Independence Award from the NIH to support his work to create a robotic system that will detect and analyze three different indicators of prostate cancer: a 3D image of any mass; high levels of a protein produced by cancer cells; and tissue with low-oxygen levels caused by cancer growth.
Zhang said the two grants synergize to enable him to advance his research into exploring the detection of aggressive prostate cancer using photoacoustic imaging, which uses the delivery of light energy to examine tissue to improve ultrasound imagery.
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‘Snakebot’ takes a dive to go where other robots can’t – GCN.com
Posted: at 12:04 pm
Snakebot takes a dive to go where other robots cant
A snake-like robot can now slither its way through water, allowing it to inspect ships, submarines, and underwater infrastructure for damage.
Researchers from the Biorobotics Lab in the School of Computer Sciences Robotics Institute at Carnegie Mellon University tested the hardened underwater modular robot snake (HUMRS) last month in the pool, diving the robot through underwater hoops, showing off its precise and smooth swimming, and demonstrating its ease of control.
We can go places that other robots cannot, says Howie Choset, professor of computer science. It can snake around and squeeze into hard-to-reach underwater spaces. Choset and Matt Travers, co-directors of the Biorobotics Lab, led the work.
Thesubmersiblerobot snake project aims to assist the Department of Defense with inspecting ships, submarines, and other underwater infrastructure for damage or as part of routine maintenance, says Matt Fischer, the program manager at the Advanced Robotics for Manufacturing (ARM) Institute.
Snakebot could save time and money
The military has limited options for inspecting areas like a ships hull. To do so, theNavymust either send a team of divers to the ships location, wait until it returns to port to deploy the divers, or pull it into a dry dock -- all options that take time and money.
A submersible robot snake could allow the Navy to inspect the ship at sea, immediately alerting the crew to critical damage or sending information about issues that need attention back to port for use when the ship docks.
If they can get that information before the ship comes into a home port or a dry dock, that saves weeks or months of time in a maintenance schedule, says Fischer, who served in the Navy for three years. And in turn, that saves money.
Fischer, who crawled into the ballast tanks of asubmarineduring his service, says many sailors would gladly pass that difficult and tight duty to a robot.
Steve McKee, a co-lead of the Joint Robotics Organization for Building Organic Technologies (JROBOT), a Department of Defense task force interested in technology like the submersible robot snake, says the project will improve the readiness of equipment in the armed services.
The advancements being made hold great promise for helping not only the Department of Defense but also various industries around the world, McKee says.
Snake in the pool!
Outside the military, therobotscould inspect underwater pipes for damage or blockages, assess offshore oil rigs, or check the integrity of a tank while it is filled with liquid. The robot could be used to inspect and maintain any fluid-filled systems, says Nate Shoemaker-Trejo, a mechanical and mechatronics engineer in the Biorobotics Lab working on the submersible snakebot.
The distinguishing feature is the robots form factor and flexibility. The smallest versions of regular submersibles are usually blocky, one-piece arrangements. The robot snake is narrow and jointed, Shoemaker-Trejo says. The end result is that an underwater robot snake can squeeze around corners and into small spaces where regular submersibles cant go.
Versions of therobot snakeshave already proven useful in difficult situations. Travers led a team to Mexico City in 2017 to use robot snakes in a search-and-rescue mission after an earthquake. And a robot snake made a lasting impression on Jimmy Fallon when it climbed up his leg as a guest on NBCsThe Tonight Show with Jimmy Fallon.
The robots modular design allows it to adapt to different tasks, whether squeezing through tight spaces under rubble, climbing up a tree, or slithering around a corner underwater. For the underwater robot snake, the team used existing watertight modules that allow the robot to operate in bad conditions. They then added new modules containing the turbines and thrusters needed to maneuver the robot underwater.
Development progressed rapidly. The team started working on the underwater robot snake in July 2020 and by March 2021, had it swimming in the pool.
Im surprised that we made this robot work as fast as we did, Choset says.
A grant from the Advanced Robotics for Manufacturing Institute funded the work.
This article was posted from Futurity.
About the Author
Jason Maderer is the interim managing director of communications at Carnegie Mellon University.
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'Snakebot' takes a dive to go where other robots can't - GCN.com
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How Vision Systems Work in Robotics – DesignNews
Posted: at 12:04 pm
Robot vision systems are commonly referred to as machine vision. This vision tool is used in several industrial processes, including material inspection, object recognition, and pattern recognition. Each industry applies its particular values to machine vision. In healthcare, pattern recognition is critical. In electronics production component inspection is important. In banking, the recognition of signatures, optical characters, and currency matter.
We talked with machine vision company, Cognex to get an understanding of how vision systems work with robotics. There are two main applications for robot guidance. You take an image of the scene and you find something and input that things coordinates. This is the angle for 2D and 3D systems. The robot can see an object and will do something with it, Brian Benoit, senior manager of product marketing for Cognex, told Design News. Another application is inspecting an object. A robot holds a camera and the robot moves the camera around the part to get certain images.
Related: How Mobile Robots Deliver Efficiency to Your Packaging Line
KUKA offers a flexible 2D vision solution for its robots by integrating with Cognex VisionPro software. The vision tools locate, inspect and read codes on stationary or moving parts.
For Cognex, the vision system often goes to integrators who cobble together automation systems.Sometimes our customer is an integrator who is building a system with robots that need vision, said Benoit. The types of robots we work with are manipulating robots. They may lift a large payload in a cage. Those are fast and unsafe to be around.
Related: Artificial Brain Gives Robots Unprecedented Sensing Capabilities
In other cases, the customer is the end-user working with smaller, safer robots, We also work with collaborative robots that are designed to work side-by-side with people. Theyre not going to use as much force, said Benoit. They often do pick-and-place. He noted that the vision systems from Cognex are not the same as the guided systems used by mobile robots. We havent seen much traction with vision on warehouse robots. They use sensors that are integrated into their system, so they dont need an outside camera.
While the large caged robots have a decades-long history, collaborative robots are a relatively new addition to the automation world. The cage robot market is stable. The most common customer is in automotive. The need for a vision system with caged robots isnt great because there isnt as much variability, said Benoit With collaborative robots, you have a more unstructured environment so there are a lot more vision applications. Its a developing market, so our strategy is to work well with any robot manufacturer. We develop software interfaces for the robot manufacturer so they can easily work with our system. With each robot, we have to develop an interface.
ABB Integrated Vision interfaces with Cognex.
The human eye is a sensor. Its our brain that understands the visual feed from our eyes. Same with robots. The robots software interprets the visual data. Software is the brain behind everything. We have two types of vision. One set of algorithms is rules-based. It looks for patterns and edges. The other algorithm is in the deep-learning space where the software is trained by example. Were seeing traction in both, said Benoit. The goal of the software is a good handshake between the robot and the vision system. We train the robot and the vision system to know where they are together. When the camera sees something, the robot knows where to go in response.
The vision software includes a plug-and-play connection for each robot maker. We try to make the integration as simple as possible. We have the right hooks in our software to send signals back and forth, said Benoit. We also rely on integrators for help on that. We work directly with some robot companies, such as Universal Robots. They have vision software thats maintained by Cognex and works directly on their robots.
Part of what sets collaborative robots apart from traditional, caged robots is they are designed to be trained by users rather than programmed by integrators. Universal Robots business model is to skip the integrators. They have a point-and-click driver, said Benoit. Its important that when they work with peripherals, they can just plug it in. They do it with our vision system and with different end effectors.
The vision system that allows the robot to identify a part and pick it up is not different from the vision system that allows the robot to check to do a quality check on a part. When the robot has a vision system whether its on a conveyor or the end of a robot arm it works the same. The vision system is mounted on a robot arm, and the arm moves around, said Benoit. The software analyzes the feed from the vision. In many cases, the software engages in deep learning. We integrated a system, all of the analysis exists inside the vision platform. We use a neural network inside the camera.
The software for the vision system may be programmed to identify a specific object, or it may be designed to learn about what its seeing. The deep-earning is different from conventional programming. Its like teaching a child what a house is. You dont normally tell the child the coordinates of a house. You say. Thats a house, thats a house, and thats an office building. Our software is designed to do that in manufacturing.
Rob Spiegel has covered manufacturing for 19 years, 17 of them for Design News. Other topics he has covered include automation, supply chain technology, alternative energy, and cybersecurity. For 10 years, he was the owner and publisher of the food magazine Chile Pepper.
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Isilon founder lifts the hood on farming startup Carbon Robotics and its weed zapping machine – GeekWire
Posted: at 12:04 pm
Carbon Robotics Autonomous Weeder uses artificial intelligence to identify and zap weeds growing in fields of vegetables. (Carbon Robotics Photo)
Carbon Robotics, a Seattle company led by Isilon Systems co-founder Paul Mikesell, is unveiling its self-driving robot that uses artificial intelligence to identify weeds growing in fields of vegetables, then zaps them with precision thermal bursts from lasers.
The startup, previously known as Maka Autonomous Robots, was in stealth mode since 2018. Mikesell sold Isilon for $2.25 billion in 2010, helped Uber open its Seattle engineering office in 2015, then moved to Facebooks Seattle Oculus lab before taking the startup plunge again.
Carbons tech holds the promise of reducing the cost of growing organic vegetables so that they no longer cost a whole paycheck.
We have all of this technology that allows, for the first time, computers to see things and understand what theyre looking at, Mikesell said. For him, the question was: how do we apply this to real physical world work? He turned to food production.
Scientists have been experimenting with laser weed-control for more than a decade after finding that the heat of lasers vaporizes water inside plant cells, destroying the cells and killing the plant. In 2013, a German company announced plans to use a laser-armed drone to zap weeds from the air.
But what farmers need is less a revolution in farming methods than a revolutionary tool that fits into their current farming patterns, Mikesell said.
Carbon worked closely with farmers in eastern Oregon and southern Idaho, he said. As a result, Carbons robot system the Autonomous Weeder was built about the size of a medium tractor so it would fit in the furrows between rows of common crops like onions and sweet potatoes.
It can cover up to 16 acres of cropland a day, zapping as many as 100,000 weeds an hour, Mikesell said. And since its self-driving, all a farmer has to do is take it to the field in the morning and turn it on.
Were really intent on not making farmers have to change how theyre doing things, Mikesell said. Thats been a key to our success. We fit right into their operations.
Weed control is an essential part of successful farming and is perhaps the essential factor for organic farmers, said Doug Collins, a soils scientist with Washington State Universitys Cooperative Extension research center in Puyallup, Wash., who serves on the Organic Advisory Board for the states Agriculture Department.
Its frequently the No. 1-cited problem, he said. Weeds can get out of hand and you can lose a crop pretty easily. The competition from the weeds can make it so the crop is not worth harvesting.
For organic farmers in particular, the cost of weed control can be high. Collins said his research on larger organic farms in the Columbia Basin showed that farmers can spend $1,200 to $1,600 an acre hiring workers to eradicate weeds by hand with hoes. Even non-organic farmers will hire hand crews to supplement the weed-killing sprays they use.
Its hard, physically demanding work, Collins said. Its not fun.
There are other alternatives for weed control like covering the space between rows with tarps or black plastic, to block weeds from getting the sunlight they need but theyre not always practical for large operations, Collins said.
One key for Carbon has been its Northwest location, Mikesell said. The region is unique in that it has a deep depth of knowledge in AI and computer visioning; an established advanced manufacturing sector; a diverse agricultural industry; and a strong venture capital community all in close proximity.
Theres not a lot of places in the world where you have all those things coming together, he said.
The 21-person startup has raised $8.9 million to date from Fuse and Bolt.
Carbon has sold out all the robots it built for the 2021 planting season, and is looking for an industrial partner who could help it build more units for 2022, Mikesell said.
The company is looking to get into the hundreds of units built and shipped for next year, he said. Theres a demand for a lot more than that, tens or hundreds of thousands of them.
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Kroger partner Ocado is on the road to robotic grocery delivery with autonomous-vehicle investment – MarketWatch
Posted: at 12:04 pm
High-tech supermarket and logistics group Ocado is pushing toward a future where, from warehouse to doorstep, groceries will be handled by robots.
The British group, a grocery delivery rival to online retail giant Amazon AMZN, +0.60% in the U.K. and joined with grocer Kroger KR, -0.22% in the U.S., will invest 10 million ($13.8 million) in a commercial partnership with Oxbotica, an autonomous vehicle software company, the company said on Friday.
Shares in Ocado OCDO, +1.87% climbed near 2% on the day, helping Londons blue-chip FTSE 100 UKX, +0.52% index top 7,000 for the first time in more than a year.
The partnership will involve collaborating on hardware and software interfaces for autonomous vehicles, Ocado said, integrating Oxford, U.K.-based Oxboticas software platform on Ocados vehicles.
Plus: Tesla self-driving truck rival TuSimple raises $1 billion in IPO valuing it at $8.5 billion
The next steps are for Ocado to fit out its delivery vans and warehouse vehicles with data capture capabilities to help Oxbotica to test its technologies. The vision is to automate the entire grocery delivery process: from vehicles that operate inside and out of Ocado warehouses, to last-mile delivery vehicles and curb-to-kitchen robots.
We are excited about the opportunity to work with Oxbotica to develop a wide range of autonomous solutions that truly have the potential to transform both our and our partners [customer fulfillment center] and service delivery operations, while also giving all end customers the widest range of options and flexibility, said Alex Harvey, Ocados head of advanced technology.
Founded by former Goldman Sachs GS, +1.11% bankers in 2000, Ocados business is built on its roots as a high-tech grocery delivery company and it is a competitive player in the cutthroat British supermarket sector. But one of its key areas for growth is creating custom logistics and warehousing solutions using its proprietary robotics technology.
Read more: Kroger and Ocado bring bots to new high-tech facility as digital competition among grocers heats up
In that vein, it has a partnership with U.S. retail giant Kroger dating back to 2018. Earlier this week, Kroger launched its first Ocado warehouse combining robotics and machine learning for fast fresh food delivery located in Monroe, Ohio, north of Cincinnati.
Ocado said the ultimate ambition of its multiyear collaboration with Oxbotica is to enable partners like Kroger to reduce the costs of both last-mile delivery and logistics operations.
The 10 million investment in Oxbotica came as part of the companys Series B equity funding round, led by the venture arm of energy giant BP BP, -0.18%, which has tested autonomous vehicles using Oxboticas technology at a refinery in Germany. Chinese tech giant Tencent 700, +1.94% and safety equipment group Halma HLMA, +0.16% were among the other investors.
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