Daily Archives: April 27, 2021

Appreciating genetic research that affects our lives – The Star Online

Posted: April 27, 2021 at 6:34 am

WORLD DNA Day is celebrated every year on April 25 to honour the achievement of the Human Genome Project (HGP), which was completed in April 2003, and the ground-breaking elucidation of the model structure of DNA double helix which was published in Nature magazine on April 25,1953. After the US Congress passed a resolution designating April 25 as DNA Day, the National Human Genome Research Institute began celebrating the day.

The HGP was an international project aimed at discovering the sequence of human DNA and defining all genes that are found in the human genome. The HGP played a big role in explaining the genetics of humans and helped us understand a variety of fundamental questions, including the total number of genes that we have, how our cells function, how diseases develop and what actually happens when we become sick.

The HGP improved biology and medicine because establishing the human genome sequence led to the designing of high-throughput sequencing technologies, and encouraged scientists, doctors and the community to discuss the ethical and social problems raised by such technologies.

Facts discovered about our DNA are quite amazing. For instance, siblings with the same mother and father, except identical twins, share 50% of their DNA. Uncle-nephew or aunt-nephew/niece share 25% of their DNA while cousins share 12.5%. When the HGP was completed, it was found that humans contain approximately 25,000 genes. These genes differ in size from a few hundred DNA bases to over two million bases. Each individual inherits two copies of each gene, one from each parent. Humans are 99.9% genetically similar and it is the 0.1% difference that makes each of us unique.

One of the biggest beneficiaries of the HGP is the field of medicine. Data from a patient's genetic profile may assist doctors in selecting the appropriate drug or treatment and administering it at the appropriate dose or regimen. This new approached in healthcare is called personalised or precision medicine. Every day, new genetic data is being profiled and used to improve the implementation of personalised medicine. As more DNA data is understood, personalised medicine may soon become routine and a part of mainstream medicine.

Besides blood, DNA can be extracted from skin, saliva, amniotic fluid and other tissues. These specimens can be studied in a genetic lab for variations in genes, DNA or proteins. Services for such genetic testing are now available online. Many companies are now offering direct to consumer genetic testing which offers the public genetic tests without having to go through a medical doctor.

Anyone can now order a genetic test by contacting these companies which will then send test kits that provide manuals and tools for extracting a saliva sample or a buccal smear that contains DNA in the comfort of their home. The specimen can then be delivered to a laboratory where the search for unique variations in genes or DNA is carried out.

While such direct to consumer genetic testing has helped many people to know more about their DNA, it must be understood that genetic data analysis is complicated and contextual reliant, and the results can yield false positive and false negative outcomes.

Anyone who is worried about the outcome of a direct to consumer genetic test should ask for guidance from a certified clinical geneticist or a genetic counsellor. The public should understand that these new technologies and approaches are intended to assist clinicians and they are not without their limitations and shortcomings.

Geneticists, health professionals, educators and the general public should join hands in the effort to study our DNA and appreciate current developments in genetic research that contribute to advances that affect our lives.

PROF ZILFALIL ALWI

Head, Malaysian Node of the Human Variome Project (MyHVP) & President, Malaysian Society of Human Genetics (MSHG)

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Appreciating genetic research that affects our lives - The Star Online

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Thomas Brock, Whose Discovery Paved the Way for PCR Tests, Dies at 94 – The New York Times

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The PCR technology, which requires cycles of extreme heating and cooling, can multiply small segments of DNA millions or even billions of times in a short period. It has proved crucial in many ways, including the identification of DNA at a crime scene and, more recently, detecting whether someone has the coronavirus.

PCR is fundamental to everything we do in molecular biology today, said Yuka Manabe, a professor of medicine in the division of infectious diseases at the Johns Hopkins University School of Medicine. Mullis couldnt have done PCR without a rock-stable enzyme.

April 27, 2021, 5:57 a.m. ET

Thomas Dale Brock was born on Sept. 10, 1926, in Cleveland. His father, Thomas, an engineer who ran the boiler room at a hospital, died when Tom was 15, pushing him and his mother, Helen (Ringwald) Brock, a nurse, into poverty. Tom, an only child, took jobs in stores to help her.

When he was a teenager, his interest in chemistry led him to set up a small laboratory with a friend in the loft of a barn behind his house in Chillicothe, Ohio, where he and his mother lived after his fathers death. The two friends experimented there with explosives and toxic gas.

After serving in the Navys electronics training program, Dr. Brock earned three degrees at Ohio State University: a bachelors in botany and a masters and a Ph.D. in mycology, the study of fungi.

With faculty jobs in short supply, Dr. Brock spent five years as a research microbiologist at the Upjohn Company before he was hired as an assistant professor of biology at Western Reserve University (now Case Western Reserve University) in Cleveland. After two years, he became a postdoctoral fellow in the universitys medical school. In 1960, he joined the department of bacteriology at Indiana University, Bloomington, where he taught medical microbiology.

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Thomas Brock, Whose Discovery Paved the Way for PCR Tests, Dies at 94 - The New York Times

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Gaucher Disease Treatment Market 2021 | Size, Growth, Key Players, Supply Chain And Forecast : Acetelion Pharmaceutical (J&J Ltd.) Shire Human…

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Gaucher Disease Treatment Market 2021 | Size, Growth, Key Players, Supply Chain And Forecast : Acetelion Pharmaceutical (J&J Ltd.) Shire Human...

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The Week of April 26, 2021 – FYI – FYI: Science Policy News

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Soil Biochemist Asmeret Berhe Picked to Lead DOE Science Office

As part of a set of nominees announced last week, President Biden named Asmeret Berhe as his pick to lead the Department of Energys Office of Science. The office oversees a fleet of scientific user facilities and 10 of DOEs 17 national labs, and with a $7 billion budget, it is the federal governments largest funder of fundamental research in the physical sciences. Berhe currently is a biogeochemist at the University of California, Merced, specializing in how organic matter in the soil responds to climate change and other environmental perturbations. Originally from Eritrea in East Africa, she earned a bachelors degree from the University of Asmara in 1996 and a doctorate from the University of California, Berkeley in 2006, and she has been on the faculty at UC Merced since 2009. Berhes expertise accords with the Biden administrations focus on climate change, and she has been a frequent user of Pacific Northwest National Labs Environmental Molecular Sciences Lab, which is supported by the Office of Sciences Biological and Environmental Research program. She is also a proponent of increasing diversity and equity in STEM and is a key player in the ADVANCEGeo Partnership, a National Science Foundation-funded effort to combat sexual harassment and other issues affecting workplace climate in the geosciences. Biden has not yet named a nominee to be under secretary for science and energy, a position that oversees the Office of Science and DOEs applied energy R&D programs. For up-to-date information on nominations to key science positions, consult FYIs Federal Science Leadership Tracker.

President Biden also announced he is nominating oceanographer Richard Spinrad to lead the National Oceanic and Atmospheric Administration. Spinrad is currently a professor at Oregon State University and has held several roles at NOAA over the last two decades, serving as its chief scientist and as head of the Office of Oceanic and Atmospheric Research and National Ocean Service. While at NOAA, Spinrad co-chaired the White House committee that developed the nations first decadal ocean research strategy and worked to advance NOAAs proposal to establish a National Climate Service. Prior to joining NOAA, Spinrad served in leadership positions in research and oceanography offices within the U.S. Navy.

Several other nominations for research-related roles were also announced last week:

The National Academies announced last week that University of Florida biologist Robert Ferl and MIT materials scientist Krystyn Van Vliet will co-chair the next decadal survey on biological and physical sciences research in space. The survey will suggest priorities for NASAs program that supports research projects in spaceflight environments, such as aboard the International Space Station. Responsibility for the program was transferred from the agencys human exploration directorate to its science directorate in 2020. In addition to identifying emerging research frontiers, the survey will consider topics such as potential research campaigns, the role of commercially operated space platforms, opportunities for collaboration with international partners, and the limited lifetime of the ISS. The study is expected to be completed in 2023.

At the White Houses climate leadership summit last week, President Biden announced that by 2030 the U.S. will halve its greenhouse gas emissions from 2005 levels, in an effort to set higher expectations ahead of the United Nations climate conference later this year. Presidential Climate Envoy John Kerry called the goal ambitious but appropriate and achievable, saying that meeting it will require new technologies in areas such as battery storage and carbon capture systems. To that end, the White House Council of Economic Advisors released a report last week outlining actions the U.S. could take to accelerate energy innovation and encourage greater private-sector R&D investment. Senior administration officials also announced new multinational initiatives, including a forum with several other oil and gas-producing nations to develop pragmatic net-zero emission strategies, and an agreement with India to speed up clean energy deployment.

At a House Science Committee hearing last week, lawmakers discussed the prospects of creating a climate service to facilitate access to climate information from across the federal government. Environment Subcommittee Chair Mikie Sherrill (D-NJ) highlighted the potential for growing inequities in access to climate and weather data if the private sector takes too large a role, saying that not all communities can hire consultants or a climate services firm to help them incorporate climate risk into their resilience planning. Pointing to two bills she has sponsored aimed at improving understanding of flood risks, she said they are just one piece of the puzzle when it comes to improving authoritative and actionable federal tools and technical assistance for climate adaptation. While Committee Ranking Member Frank Lucas (R-OK) has stressed the need for climate information in areas such as agriculture, he and Subcommittee Ranking Member Stephanie Bice (R-OK) questioned whether a dedicated service is necessary. Lucas argued the National Oceanic and Atmospheric Administration already serves that function and that establishing a new duplicative service only serves to create more red tape and hurdles to our budding weather industry.

At a meeting last week, the Senate Foreign Relations Committee approved bipartisan legislation aimed at better positioning the U.S. to compete with China. It includes a provision empowering the Committee on Foreign Investment in the United States (CFIUS) to block universities from accepting certain foreign gifts and contracts, including ones worth more than $1 million that relate to critical technologies. Committee Ranking Member Jim Risch (R-ID) has said the provision is his top priority, citing a desire to help prevent the Chinese government from exerting influence on universities and to address risks of intellectual property theft. A group of university associations wrote to the committee before the meeting to oppose the provision, stating it would require expensive and time-consuming reviews of a wide range of university gifts and contracts against unknown and ill-defined criteria by an agency not designed or equipped to carry out this task. They also argued that uncertainty created by what might be blocked by CFIUS reviews will be a significant disincentive for philanthropic giving, undercutting U.S. competitiveness. American Council on Education President Ted Mitchell told Bloomberg that granting such a denial authority over research projects not funded by the federal government would be unprecedented. His organization has estimated that about 700 gifts and contracts that were reported to the Department of Education in 2019 could be subject to review under the proposal. To address some of these concerns, the committee adjusted the provision to require CFIUS to consider input from science agencies. The bill now heads to the Senate floor, where it could be bundled with the Endless Frontier Act.

At a Senate hearing last week, the National Institutes of Health provided updated statistics on its investigation of scientists for policy violations such as failing to disclose substantial employment ties with foreign entities, mainly in China. NIH extramural research head Mike Lauer told the committee the agency has identified more than 500 scientists of concern to date and that more than 100 have been removed from the NIH ecosystem through a variety of ways resignations, terminations, premature retirements, internal debarments. He emphasized that the violators represent only a small fraction of NIH grantees and remarked, We remain conscious of how these [enforcement] actions could affect the morale of honest and dedicated foreign researchers, particularly in the context of a pandemic that has exacerbated acts of discrimination and harassment against Asian Americans. The vast majority of Chinese scientists working in America are committed to the cause of expanding knowledge for the betterment of humankind, and to do so in a fair and honest way. We must say this at every opportunity. Senators generally did not question NIHs investigative approach to date, though Health Committee Ranking Member Richard Burr (R-NC) expressed concern that no one entity is responsible for identifying cases in which scientists have falsified information or violated rules.

Last week, the National Academies released a report from a study evaluating the U.S. research enterprises ability to monitor and help prevent the international proliferation of nuclear weapons and fissile material. Congress mandated the study and set a short deadline for it after deeming updates the National Nuclear Security Administration submitted on the subject to be unsatisfactory. However, because of disruptions caused by the COVID-19 pandemic, the Academies divided the study into two phases. The new report conveys findings from the first phase, which covers work the committee was able to undertake immediately. It offers 16 recommendations, including formalizing interagency coordination of nonproliferation efforts, expanding NNSAs testbed infrastructure and nuclear nonproliferation stewardship program, and bolstering the agencys technology transition activities. The report notes such efforts would require additional funding, but defers discussion of specific amounts to the studys second phase. The studys chair to date, former Sandia National Labs Director Jill Hruby, was recently nominated by President Biden to lead NNSA.

Leaders from the Defense Advanced Research Projects Agency and the R&D arms of the three military departments updated the Senate Armed Services Committee last week on recent efforts to increase innovation capabilities. Among the programs they spotlighted were Army Futures Commands Team Ignite, the Navys NavalX, and the Air Force Research Labs Transformational Capabilities Office and Vanguard programs, all of which aim to facilitate R&D collaborations and spur technology projects that respond to pressing military needs. The witnesses also pointed to exercises such as the Armys soldier touch points and Project Convergence and the Navys Integrated Battle Problem 21, which concludes this week, as key examples of efforts to integrate the development of technology and military tactics.

Lawmakers introduced a variety of science-focused bills in recent weeks, including ones focused on the STEM workforce, research security, quantum information science, energy research, manufacturing, and weather and climate forecasting:

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The Week of April 26, 2021 - FYI - FYI: Science Policy News

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Elon Musk: Mars Isn’t for Rich PeopleIt’s for Explorers Who Will ‘Probably Die’ – Popular Mechanics

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Last year, Elon Musk caused a stir when he said something provocative, but ultimately correct: theres a good chance the first Mars settlers will die. Now, the SpaceX mastermind, who is dead set on colonizing the Red Planet, is doubling down on that sentiment.

In a recent livestream touting his $100 million XPrize reward to whoever can figure out carbon removal, Musk dispelled the notion that the initial Mars journey will be some escape hatch for rich people.

Musk elaborated:

Of course, wealthy people and explorers arent two mutually exclusive groups. Deep-pocketed daredevils like James Cameron, for example, have made dangerous exploration their business, because having generational wealth often goes hand in hand with funding these kinds of expeditions.

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In his comments, Musk referred to Sir Ernest Shackleton, who led the first attempted trans-Antarctic crossing in 1914. Shackleton was highly decorated and honored during his lifetime, but he definitely wasnt wealthyat least not for long. He came from a working class family and was usually trying to accumulate wealth somehow, whether by making risky business investments or spending all his money on expeditions.

The key to surviving the desperate conditions that await the first Martian settlers isnt having moneyits balancing their response to predictable events (limited water, no atmosphere, radiation) and developing a resiliency against unpredictable events, Jennifer Buz, Ph.D., an areologist at Northern Arizona University, told Pop Mech last year.

Theres a lot you can plan for, Buz said, so you could kind of prolong your life to an extent, but theres always going to be something thats not perfectly accounted for.

Mars settlers will likely need to live in underground caves and carefully monitor and dole out all the necessary resourcescertainly no place for anyones economic status to make a difference. Even the popular first Mars city plans put an emphasis on the per-person cost of buying uniform housing and travel, not of an optional economy of luxury goods once youre there.

That Musk called Mars tough sledding speaks directly to Shackleton and other Antarctic explorers trips across the ice on sleds or sledges. No, Mars wont literally involve sleds, but well have to carry all the resources we need all the way to the Red Planet, and then into the sheltered human settlements, and then out with any waste products.

In fact, our lives on Mars will need to be part of one of the most closed, circular systems ever devisedquite the opposite of the way Earths economies are often stratified and unjust. Musks urge to go to Mars is caused in part by the way previous generations of explorers have colonized and exploited resources around the world.

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Elon Musk: Mars Isn't for Rich PeopleIt's for Explorers Who Will 'Probably Die' - Popular Mechanics

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In space, no one will hear Bezos and Musks workers call for basic rights – The Guardian

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Elon Musks SpaceX just won a $2.9bn Nasa contract to land astronauts on the moon, beating out Jeff Bezos.

The money isnt a big deal for either of them. Musk is worth $179.7bn. Bezos, $197.8bn. Together, thats almost as much as the bottom 40% of Americans combined.

And the moon is only their stepping stone.

Musk says SpaceX will land humans on Mars by 2026 and wants to establish a colony by 2050. Its purpose, he says, will be to ensure the survival of our species.

If we make life multi-planetary, there may come a day when some plants and animals die out on Earth but are still alive on Mars, he tweeted.

Bezos is also aiming to build extraterrestrial colonies, but in space rather than on Mars. He envisions very large structures, miles on end that will hold a million people or more each.

Back on our home planet, Musk is building electric cars, which will help the environment. And Bezos is allowing us to shop from home, which might save a bit on gas and thereby also help the environment.

But Musk and Bezos are treating their workers like, well, dirt.

Last spring, after calling government stay-at-home orders fascist and tweeting FREE AMERICA NOW, Musk reopened his Tesla factory in Fremont, California before health officials said it was safe to do so. Almost immediately, 10 workers came down with the virus. As cases mounted, Musk fired workers who took unpaid leave. Seven months later, at least 450 Tesla workers had been infected.

Musks production assistants, as theyre called, earn $19 an hour hardly enough to afford rent and other costs of living in northern California. Musk is virulently anti-union. A few weeks ago, the National Labor Relations Board found that Tesla illegally interrogated workers over suspected efforts to form a union, fired one and disciplined another for union-related activities, threatened workers if they unionized and barred employees from communicating with the media.

Bezos isnt treating his earthling employees much better. His warehouses impose strict production quotas and subject workers to seemingly arbitrary firings, total surveillance and 10-hour workdays with only two half-hour breaks often not enough time to get to a bathroom and back. Bezos boasts that his workers get $15 an hour but that comes to about $31,000 a year for a full-time worker, less than half the US median family income. And no paid sick leave.

Bezos has fired at least two employees who publicly complained about lack of protective equipment during the pandemic. To thwart the recent union drive in Bessemer, Alabama, Amazon required workers to attend anti-union meetings, warned theyd have to pay union dues (untrue Alabama is a right-to-work state), and threatened them with lost pay and benefits.

Musk and Bezos are the richest people in America and their companies are among the countrys fastest growing. They thereby exert huge influence on how other chief executives understand their obligations to employees.

The gap between the compensation of CEOs and average workers is already at a record high. They inhabit different worlds.

If Musk and Bezos achieve their extraterrestrial aims, these worlds could be literally different. Most workers wont be able to escape into outer space. A few billionaires are already lining up.

The super-rich have always found means of escaping the perils of everyday life. During the plagues of the 17th century, European aristocrats decamped to their country estates. During the 2020 pandemic, wealthy Americans headed to the Hamptons, their ranches in Wyoming or their yachts.

The rich have also found ways to protect themselves from the rest of humanity in fortified castles, on hillsides safely above smoke and sewage, in grand mansions far from the madding crowds. Some of todays super rich have created doomsday bunkers in case of nuclear war or social strife.

But as earthly hazards grow not just environmental menaces but also social instability related to growing inequality escape will become more difficult. Bunkers wont suffice. Not even space colonies can be counted on.

Im grateful to Musk for making electric cars and to Bezos for making it easy to order stuff online. But I wish theyd set better examples for protecting and lifting the people who do the work.

Its understandable that the super wealthy might wish to escape the gravitational pull of the rest of us. But theres really no escape. If theyre serious about survival of the species, they need to act more responsibly toward working people here on terra firma.

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In space, no one will hear Bezos and Musks workers call for basic rights - The Guardian

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Stowaway Review: A suspenseful albeit slow-paced space expedition – Times of India

Posted: at 6:31 am

Hollywood has taken many trips to space in the past, exploring the universe's vast expanse, its apathetically ruthless nature towards man, and the isolation and helplessness of the astronauts at its mercy. Sometimes it's through the lens of enigmatic allegory (Stanley Kubrick's magnum opus 2001: Space Odyssey) or breathtaking visuals (Alfonso Cuarn's Gravity), and other times mind-bending scientific theories (Christopher Nolan's Interstellar) or even a little bit of humour (Ridley Scott's The Martian).

Director Joe Penna's expedition to Mars in the 2021 movie Stowaway is neither as ambitious, nor mounted on as grand a scale, as the ones mentioned above. Instead, it unfolds in the rather claustrophobic confines of the Kingfisher, that is en route to a Mars colony. The cast is threadbare, but solid - Anna Kendrick as medical researcher Zoe, Toni Collette as the ship's commander Marina, and Daniel Dae Kim as biologist David. Toni's Marina is confident and steady and Daniel's David stoic yet a softie, but Anna kind of steals the frame as the adorkable space rookie, Zoe.

The crux of the film's story is a moral dilemma involving Kingfisher's titular and accidental stowaway - Michael Adams (Shamier Anderson), whom the crew finds stashed away and injured in a compartment of the craft. As they nurse him back to recovery, they realise that they don't have enough oxygen for four people. It soon becomes clear that one person (and that person being Michael, of course) has to die for the other three to live.

Each of the characters deals with the ethical quandary in their own way - Marina as the no-nonsense leader and David as the scientific pragmatist, both of whom understand that the success of their mission (that involves making Mars fit for human habitation), the fate of humanity, as well as their own lives, ride on eliminating Michael from the equation. On the other hand, Michael is the powerless someone who knows he's in the wrong place at the wrong time, and Zoe the idealist who will keep looking for alternate sources of oxygen rather than let this man die.

Visually, there's not much to fault with the movie and the scenes that unfold in space - especially when we finally leave the Kingfisher at some point in the second half - are well done. It's the pacing that's a letdown, and labeling it a thriller might be an overstatement. The film isn't exactly edge-of-your-seat until its fag end, and meanders quite a bit before making its point. However, among its strengths are its characters, that aren't cookie-cutter and have great chemistry. In fact, they're all endearing in their own way (even Michael, though his part is slightly under-cooked) which is what makes the story's haunting conclusion stay with you.

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Stowaway Review: A suspenseful albeit slow-paced space expedition - Times of India

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First breathable air produced on another planet – CBC.ca

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While the first flight of the Mars helicopter got a lot of attention this week, an experiment on the Perseverance rover quietly accomplished another first, by making oxygen out of the Martian atmosphere.

Embedded within the body of Perseverance is a toaster-sized instrument called MOXIE (Mars Oxygen In-Situ Resource Utilization Experiment). The instrument is a technology demonstrator that produced fivegrams of oxygen from the mostly carbon dioxide Martian air.

Five grams is not a lot of oxygen. It would only keep you alive for about 10minutes, but the success of this test is a huge step towardsending humans to live on the Red Planet, and bringing them home again.

In simplest terms, Mars will kill you. The atmosphere is extremely thin, only one per centthe pressure ofEarth's, and is almost entirely made of carbon dioxide with only 0.16 per centoxygen. Compare that to the 20 per centoxygen in the Earth's much thicker atmosphere. That means explorers from Earth will need to provide their own oxygen by either bringing it from Earth, which is hugely expensive, or making it from resources on Mars.

MOXIE drew in a sample of Martian air, then using a combination of heat and electrochemistry, split the carbon dioxide molecules apart producing oxygen and carbon monoxide. The experiment proved that the process works, so in theory larger units could supply breathable air for Martian colonists.

The advantage of a MOXIE-like system is that it can be set up easily and start producing oxygen right away no matter what the location. But there is another source of oxygen on Mars ice. Like Earth, Mars has ice at the polar caps, and likely has significant amounts of sub-surface ice-rich permafrost

Not only is ice a source of water but you can crack that water into hydrogen and oxygen for both breathing and rocket fuel. Those elements can be extracted from water by electrolysis, or using electricity to break water molecules into their component elements. Ice deposits at the south pole of the moon might also be a sought after resource for lunar colonists.

Having a reliable oxygen supply on Mars is a big deal because the first humans to go there will be in for the long haul. Due to orbital mechanics of Mars and Earth, the two planets orbit the sun at different speeds, with Mars taking the outside track on the elliptical course around the sun so its year is twice as long as ours. A crew must launch towardMars when both planets are close together on the same side of the sun, but by the time they get there seven months later, the Earth will have zoomed ahead on the inside track out of reach. So they will have to wait for their home planet to circle the sun and catch up to Mars again before they can make the return journey. That could take up to a year.

Martian colonists will be homesteaders, like early pioneers, living off the land as much as possible. It will be a risky existence in the cold dry desert environment. Any problems will have to be dealt with on the spot because help is millions of kilometres and many months away.

Perhaps they will occasionally look up at a small blue dot in the pink Martian sky and think about their home planet, the only one we know of where oxygen is plentiful, the only place where a person can step outside, take a deep breath and not have to wear a space suit.

As we celebrate Earth Day this week, let's remember that while the other planets are incredibly interesting, there is literally no place like home. So go outside and breathe some oxygen. It's free on this planet.

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First breathable air produced on another planet - CBC.ca

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‘Stowaway’ review: Small cast and big emotion fuel space thriller – The Young Folks

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The vastness of space is both wondrous and horrifying. Its amazing to explore the endless list of what surrounds the planet, but shocking to learn how those surroundings are all-consuming nothing . Walking through zero gravity looks cool, but remarkably less-so when you realize how no gravity means no control. Space is as scary as it is special, which is why its been such a constant setting for science-fiction movies. For every laser gun fired, spaceship going at lightspeed, or alien monster birthed, there have also been movies that tackle isolation, fear, morality and the human condition. Taking the imagination and wonder of outer space and turning it into something intimidating is a bold move for any filmmaker, but its a very thin line to walk across successfully, one that Stowaway, the latest film at Netflix, tries to accomplish.

The set up for the story is rock solid. A private company is sending a three-person team on a two-year mission to start a colony on Mars. Theres team commander Marina (Toni Collette), medical professional Zoe (Anna Kendrick) and botanist David (Daniel Dae Kim) who are all feeling the weight of their mission but excited to take this great leap for mankind. Then a problem literally drops-in; Michael (Shamier Anderson), an engineer for the company who was working on the teams space station before takeoff when he suffered an injury and passed out while still on board. Michael is desperate to get back to Earth while the team is adjusting to having an unexpected fourth member on board. Not only that, but it turns out the ship doesnt have enough oxygen to support the now four-person team all the way to Mars. Now the team has to decide what survives: Michael or their mission.

This is not the first time co-writer/director Joe Penna has told a story of survival in a desolate location, having made the frigid drama Arctic two years ago. With its high-tech implications and likely pricier setup, Stowaway is a more of a challenge for Penna and its one that he frequently rises to. He sets the mood for most scenes with little exposition and good visual storytelling, whether it involves showing the restricted set of the space station or the gravity (no pun intended) of Michaels situation when he first wakes up from his injury. He manages to humanize his small group of characters, all brilliant professionals in their own rights while being both logical and humane to Michael. Hes also good at emphasizing the tense atmosphere of problem-solving in space, especially in the climactic space walk along the station.

Its just a shame that Penna and co-writer Ryan Morrison crafted the story from territory mined by the likes of Apollo 13, Armageddon, Gravity and Ad Astra, which all harnessed drama from the cold depths of space. In fact, Stowaway is basically an inverse of Ridley Scotts 2015 hit The Martian where instead of a man in the dire circumstances of being marooned on Mars, its a team on a mission to Mars stuck with a man making their situation dire. It also doesnt have the energy that The Martian had in seeing botanist Mark Watney progress in his own survival and the NASA team figuring out how to save him. Instead, its a visually flat and progressively dour affair only helped by the commitment of the actors and the lush score from Oscar nominee Volker Bertelmann (Lion, The Old Guard, Ammonite). And while the movie has a solid pace at 116-minutes long, the movie seems to just stop after its rather moving climax without a proper conclusion. Its as if Penna just ran out of time (or money) to film the movies last ten minutes.

None of the shortcomingstime-wise or otherwiseof Stowaway fall on its cast. The four actors here all carry the dramatic weight of the movie effectively and in different ways. Collette bears the burden of being in-charge of a situation she has no control over and makes the audience feel for her having no safe solutions to the problems at hand. Kim is more reserved but seething with anger and frustration that his lifes work is being sacrificed for some unforeseen complication. Even Anderson, being the wild card of this whole story, is never over-emphasized or given some kind of dramatic twist in his character development. He plays being in the wrong place at the wrong time with patience and a perfect reaction to how dire his situation is. The real surprise here though is Kendrick, mostly known for comedies or being the comedic foil in dramas (see her Oscar-nominated performance in Up in the Air), whose character is trying desperately to save Michaels life out of basic human decency and a prior experience. Kendrick isnt showy in her performance, getting the frantic struggle of her character across in focused bursts of stress and heartache. Shes the conscience of the movie and seeing her wither away the worse the situation gets is heartbreaking.

Though slightly flawed and unoriginal, theres still a compelling story in Stowaway that Penna and co. pull off. His prior methods of survival epics are shrunk down with greater intimacy here, making for tense human drama and an engaging ticking-clock element as the team scrambles to save their own lives. In a more positive comparison to The Martian, its also impressive that Penna managed to keep Stowaway engaging without the scope and star-power Scotts blockbuster had. In this new era of introspective and character-driven sci-fi thrillers, its comforting to know that a $100-million budget and lasers arent needed to make something memorable in outer space.

Stowaway is now streaming on Netflix.

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'Stowaway' review: Small cast and big emotion fuel space thriller - The Young Folks

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Bruno Mars to return to Las Vegas with July performances at Park MGM – Yahoo News

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The Week

No one enjoys wearing a face mask, and some medical experts are now saying people especially vaccinated people mostly don't need to wear them for non-intimate outdoor activities. The coronavirus does not spread as easily outdoors though it could jump from human to human if, say, infected Tucker Carlson fans get in your face to scream (politely) about how you are making them uncomfortable by wearing a mask outdoor. And if one of these triggered people also calls the cops or child protective services because your child is wearing a mask, well, that may be on Carlson, too, after his Monday night show on Fox News. Tucker Carlson is now telling his audience to harass people who wear face masks outside. If they see children wearing masks, Tucker says the response should be no different than when you see a kid being abused -- "call the police immediately, contact child protective services" pic.twitter.com/4svVH0JY3s Justin Baragona (@justinbaragona) April 27, 2021 The Federalist's Molly Hemingway evidently thought Carlson had a good, and viable, idea. legit deranged to think its possible to politely walk up to a total stranger and tell them your mask is making me uncomfortable pic.twitter.com/4K3zR3Lfxw Christian Vanderbrouk (@UrbanAchievr) April 27, 2021 Carlson's colleague Laura Ingraham hit on masked children, too, suggesting this may be a growing front in the conservative culture wars. pic.twitter.com/kBmCeMGzSM Brendan Karet (@bad_takes) April 27, 2021 The COVID-19 pandemic has not gone away, new variants seem to be hitting younger people, children are not immune, and people under 16 are not yet eligible to be vaccinated. Also, per science, masks work, even outdoors. An average of about 715 Americans are dying every day from COVID-19, a sharp drop from February but not nothing, and very few of them are children, but not zero. Presumably, Carlson is just trying to make a point about snooty mask wearers scowling at mask scofflaws, but it's unlikely 911 operators will see it that way if his viewers take him seriously. More stories from theweek.comThe Oscars finale was a heartless disaster5 brutally funny cartoons about COVID anti-vaxxersRepublicans are expected to gain seats in redrawn 2022 congressional maps, but Democrats could be worse off

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