Monthly Archives: February 2021

This is only the tip of the iceberg. For example, the vidiprinter also flagged a goal for Kenji Gorre in Portugal's Liga NOS, for Nacional. In that same league on Friday night, Angel Gomes had swept home a superb free-kick for Boavista. Back to domestic matters, the teatime game was the big one in the Premier League as Everton won the Merseyside derby at Liverpool.

The Man of the Match? Michael Keane, a member of our last FA Youth Cup-winning side. While watching him 'in the zone' at Anfield, repellingeverything Jurgen Klopp's men could muster, I recalled conducting his first club-media interview, alongside his twin brother Will (who is now with Wigan Athletic), at the Aon Training Complex many years ago. I could not have been more thrilled with his exceptional performance against Liverpool. He and Will are just two of the nicest people you could ever hope to meet.

Football is, of course, not merely about goals or even good performances. There was a big transfer story earlier in the day with Ryan Shawcross signing for Inter Miami, the Major League side owned by David Beckham and managed by Phil Neville. Our former defender enjoyed a wonderful 14 years at Stoke City and you only have to look at the way Potters fans responded to his departure to understand how much his sterling service was appreciated. He's another success story for our Academy and we all wish him well for his new adventure in the United States.

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Why Man Utd DNA is spread throughout league and beyond - Manchester United

Photo by Russell Cothren

Anastasia Makhanova.

FAYETTEVILLE, Ark. Variation in a specific gene could be related to traits that are beneficial to bonding and relationship satisfaction in the first years of a marriage, according to a new study by a University of Arkansas psychologist.

Recent research indicates that a variation called CC in the gene CD38 is associated with increased levels of gratitude. Extending that line of work, U of A psychologist Anastasia Makhanova and her colleagues used data from a study of genotyped newlyweds to explore whether a correlation existed between the CD38 CC variation and levels of trust, forgiveness and marriage satisfaction. They found that individuals with the CC variation did report higher levels of perceptions considered beneficial to successful relationships, particularly trust.

Marriage satisfaction tends to start high then drop, said Makhanova, assistant professor of psychology and first author of the study, published in the journal Nature Scientific Reports. We were interested in seeing if some of the reasons that people might have a harder time maintaining relationship satisfaction in the newlywed period is due to some potential underlying genetic predispositions.

For the work, researchers studied 142 newlyweds 71 couples a subset of a larger group used for other studies. The newlyweds DNA was collected three months after being married, and they also completed a survey at that point as well as one every four months for three years. At the end of the study, researchers compared survey results with the CD38 variations and found that those with the specific CC variation reported higher levels of traits corresponding to marriage satisfaction.

CC individuals felt more grateful for their partner, reported higher trust in their partner, were more forgiving of their partner, and were more satisfied with their marriages than were AC/AA individuals, the researchers wrote.

While the work points to a possible genetic link to marriage satisfaction,Makhanova notes that it doesnt mean those without the CD38 CC variation will not have successful relationships.

So it's not that people who don't have the CC genotype are doomed to have problems, she said. It's just that they're more likely to have issues in some of these domains, and so those people might have to work a little bit more in those domains.

About the University of Arkansas: As Arkansas' flagship institution, the U of A provides an internationally competitive education in more than 200 academic programs. Founded in 1871, the U of A contributes more than $2.2 billion to Arkansas economy through the teaching of new knowledge and skills, entrepreneurship and job development, discovery through research and creative activity while also providing training for professional disciplines. The Carnegie Foundation classifies the U of A among the top 3% of U.S. colleges and universities with the highest level of research activity. U.S. News & World Report ranks the U of A among the top public universities in the nation. See how the U of A works to build a better world at Arkansas Research News.

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Study Suggests Link Between DNA and Marriage Satisfaction in Newlyweds - University of Arkansas Newswire

Major advancements in medical science and technology, coupled with the increasing adoption of personalized medicine initiatives are likely to aid in expansion of the global DNA & RNA banking services market during the forecast period set between 2020 and 2030. Deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) share a correlative relationship wherein the DNA stores and transfers information of the genetics whereas RNA acts as a messenger between the ribosomes and DNA and produces proteins for the body. The increasing cases of cancer worldwide have propelled the need for saving and storing DNA and RNA samples for future uses. This is likely to aid in expansion of the market for DNA and RNA banking services worldwide.

The global DNA & RNA Banking Services market is classified on the basis of specimen, service, application, end use, and region. In terms of service, the market is grouped into processing, data storage, quality control, storage, transportation, and others. Based on specimen, the market is bifurcated into buccal swabs & hair follicles, blood, and others. With respect to end use, the market is classified into hospitals & diagnostic centers, pharmaceutical & biotechnology companies, academic research, and others. Based on segmentation by application, the market for DNA & RNA Banking Services is segmented into clinical diagnostics, drug discovery & clinical research, therapeutics, and others.

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The report on the global DNA & RNA Banking Services market is based on a comprehensive analysis and provides an elaborate overview of the market and its prime growth trajectories. This includes factors pushing up the growth rates of the market or creating hurdles for it. The report also emphasizes on the table of segments, and mentions the name of the dominating segment with its attributed factors. Furthermore, the report highlights the impact of the COVID19 pandemic on this market, analyzes the strategies that may turn out to be fruitful for the growth of the market in the years to follow.

DNA & RNA Banking Services Market: Competitive Landscape

Major vendors of this market are adopting various tactics to widen their presence in the overall market competition. Some players are investing heavily on research and development, of better storage options for RNA and DNA specimens and on clinical trials so as to ensure their quality and purity and to generate more revenues for their brand in order to emerge as a top leader or maintain their already existing position in the worldwide competition. Other players are indulging in joint ventures, partnerships, and similar collaborations to emerge as a strong contestant and gain a foothold in the competition.

Some of the players functioning in this global market for DNA and RNA banking services are;

DNA & RNA Banking Services Market: Trends and Opportunities

The increasing number of newly constructed and recently functioning imaging biobanks serves as the key factor aiding in expansion of the global market for DNA and RNA banking services market. In addition to this, the advancement in medical imaging and the use of computed tomography for identification and validation of non-invasive biomarkers for collecting images will also promote the growth of the market in the coming years.

DNA & RNA Banking Services Market: Regional Analysis

Geographically, the global DNA and RNA banking services marker is widespread into the regions of North America, Europe, Asia Pacific, Europe, and the Middle East and Africa. These regions are further classified on the basis of nations. Among these, North America emerged dominant and is likely to continue the same in the coming years as well, attributed to the presence of multiple biobanks. Moreover, the continuous efforts made by the government of Canada and the U.S. on storing tissue, blood, and other forms of specimens will also help the region witness significant growth.

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DNA & RNA Banking Services Market | Exclusive Report on the Latest Trends and Opportunities - BioSpace

A study published this week in Science Translational Medicine describes how urinalysis could potentially be used to detect some forms of cancer.

Currently, cancers are detected and diagnosed using more invasive methods such as surgical biopsies of suspected tumors and blood draws. Urinalysis has long been used to detect and manage many diseases and disorders, but not cancer.

Emily Kumlien608-516-9154ekumlien@uwhealth.org

Researchers investigated whether fragments of cell-free DNA in urine could be analyzed to detect early-stage cancer. Previously, DNA fragments in urine were thought to be degraded at random and were too short to provide any meaningful information about complex diseases such as different forms of cancer. However, in an initial proof-of-concept study, the research team found that DNA fragmentation patterns in urine samples were not random, and that patterns could allow them to distinguish between healthy individuals and those with pancreatic cancer or certain types of pediatric cancers.

The study was led by Dr. Muhammed Murtaza, visiting associate professor of surgery and Center for Human Genomics and Precision Medicine at the University of Wisconsin School of Medicine and Public Health. The work was performed while Murtaza was at the Translational Genomics Research Institute in Arizona.

There are many steps between where we are now and where we want to go confirming cancer from a urine sample but without doubt this is an encouraging first step, said Murtaza. We are eager to continue this research further and hope it will someday enable us to detect cancer earlier, which could improve mortality by enabling treatment at earlier stages.

While early results are promising, the researchers indicate the need to test their findings in much larger populations of cancer patients in comparison to healthy individuals, and identify differences between men and women, different ages, and those with co-morbidities, such as diabetes and other chronic diseases.

Murtaza is available for interviews on this topic today, and a pre-recorded video interview is also available.

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Study finds analyzing DNA in urine could help detect cancer - University of Wisconsin-Madison

Gif: A. L. B. Payne et al., 2021/Nature Communications

Scientists have captured the highest-resolution images ever taken of DNA, revealing previously unseen twisting and squirming behaviors.

Deoxyribonucleic acid, otherwise known as DNA, can be surprisingly active when crammed and contorted inside a cell, according to new research published in Nature Communications. These hidden movements were revealed by computer simulations fed with the highest-resolution images ever taken of a single molecule of DNA. The new study is exposing previously unseen behaviors in the self-replicating molecule, and this research could eventually lead to the development of powerful new genetic therapies.

Seeing is believing, but with something as small as DNA, seeing the helical structure of the entire DNA molecule was extremely challenging, Alice Pyne, the first author of the paper and a materials scientist at the University of Sheffield, said in a statement from the university. The videos we have developed enable us to observe DNA twisting in a level of detail that has never been seen before.

Scientists have previously used microscopes to gaze upon DNA and its twisted ladder-like configuration, but these were limited to static views of the molecule. What scientists havent been able to see is how the intense coiling of DNA affects its double-helical structure. To accomplish this, Pyne and her colleagues combined high-resolution atomic force microscopy (AFM) with molecular dynamics computer simulations, which revealed the writhing.

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Long, highly organized strands of DNA are crammed tightly inside our cells. As the new study shows, this results in some surprisingly dynamic physical behaviors.

Agnes Noy, a lecturer at the University of York and a co-author of the study, said the microscopy images and the computer simulations agreed so well that they boosted the resolution of their experiments, allowing the team to track how each atom of the double helix of DNA dances.

For the study, the researchers analyzed DNA minicircles, in which a small strand is joined at both ends, forming a loop structure. DNA minicircles have been described before, and theyre believed to be important indicators of health.

Microscopic images of DNA minicircles in their relaxed position (i.e. no twists) revealed very little movement, but extra twists brought the loop to life, resulting in more vigorous movements. These dynamic moves may serve an important purpose, helping the DNA to find binding partners and facilitate growth.

The new atomic force microscopy shows, with remarkable detail, how wrinkled, bubbled, kinked, denatured, and strangely shaped the DNA minicircles really are, which we hope to be able to control someday, Baylor College of Medicine biologist Lynn Zechiedrich, who supplied the minicircles for the study, said in the University of Sheffield statement.

Indeed, further insights into DNA, and how its able to get so compact, could lead to the development of completely new medical interventions, including improved DNA-based diagnostics and therapeutics, according to the researchers.

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Highest-Resolution Images of DNA Reveal It's Surprisingly Jiggly - Gizmodo

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New Delhi: An estimated 50 per cent of the Indian population is less susceptible to severe Covid-19, and its probably because Neanderthals and modern humans got naughty with each other tens of thousands of years ago. Or so claims a group of researchers from Japan and Germany.

According to researchers behind a study published in PNAS last week, nearly half the Indian population has inherited a 75,000-character-long DNA sequence from Neanderthals that is believed to reduce the risk of severe disease due to Covid-19.

Conducted by researchers from Okinawa Institute of Science and Technology Graduate University (OIST) in Japan and the Max Planck Institute for Evolutionary Biology in Germany, the study sought to examine a gene variant that was linked to a 22 per cent reduced risk of severe Covid-19 and ICU admissions in another study conducted in December. It found the variant identical to one found in three different Neanderthal specimens.

This is not the first piece of research to find a link between Neanderthals, a species of ancient humans that became extinct 40,000 years ago, and Covid susceptibility in modern human beings.

In July last year, a study by researchers at the Max Planck Institute for Evolutionary Anthropology found that a piece of the human genome that increases the risk of severe illness from Covid-19 was inherited from Neanderthals over 60,000 years ago. An estimated 30 per cent of South Asians are believed to carry this gene sequence.

Its quite amazing that despite Neanderthals becoming extinct around 40,000 years ago, their immune system still influences us in both positive and negative ways today, Svante Pbo of OIST said in a statement released with the study.

Hugo Zeberg, one of the authors of the study, told ThePrint that nearly 50 per cent of Indians carry this DNA sequence. The frequency of this gene variant is 49.5 per cent in Gujaratis, and 48 per cent in the Telugu population, he added.

Also read: Neanderthals were no brutes. They were precise workers capable of caring for the weak

Neanderthals evolved in western Eurasia about half a million years ago. However, their genes continue to have a biological impact on the physiology of modern humans, since they mingled with human populations during the last tens of thousands of years of their existence.

The Neanderthals adapted to environments outside Africa over the hundreds of thousands of years they lived there. During this time, they also likely adapted to infectious diseases.

Interbreeding between Neanderthals and modern humans who are believed to trace their roots to Africa is said to have led to the exposure of each species to novel viruses, and exchange of adaptive gene variants that provided resistance against these viruses.

For example, two gene variants that decrease the susceptibility to Helicobacter pylori infectious bacteria that cause stomach inflammation and some types of stomach cancer are believed to have been inherited from Neanderthals.

The aforementioned July 2020 study said a gene variant in a region on chromosome 3, inherited from the Neanderthals, increased the risk of becoming critically ill upon infection with SARS-CoV-2, the virus that causes Covid-19.

Chromosomes are thread-like structures located inside the nucleus of cells. Humans have 23 pairs of chromosomes. Each chromosome is made of protein and a single molecule of deoxyribonucleic acid (DNA).

DNA contains the specific instructions or genetic code that makes each individual unique.

In December, a team of researchers from the University of Edinburgh found that gene variants located on chromosome 12 reduce the risk that an individual will require intensive care after infection by about 22 per cent.

The study published in PNAS last week shows that this variant is almost identical to those found in three Neanderthals a 50,000-year-old Neanderthal from Croatia, and two from southern Siberia, one dating back 70,000 years and the other, 120,000 years.

Chromosome 12 spans almost 134 million DNA building blocks (base pairs) and represents between 4 and 4.5 per cent of the total DNA in cells.

The gene variant sequence mentioned in this paper is about 75,000 base pairs.

Three genes in the sequence of 75,000 base pairs code for enzymes that are produced upon viral infection and, in turn, activate other enzymes that degrade viral genomes in infected cells. Simply put, three genes help the body kickstart the biological process that attacks the virus when it infects cells.

It seems that the enzymes encoded by the Neanderthal variant are more efficient, reducing the chance of severe consequences to SARS-CoV-2 infections, Pbo said.

Also read: The Neanderthal gift thats serving us humans well

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Why 50% Indians will be happy to have some Neanderthal DNA. Hint: It has to do with Covid - ThePrint

Researchers have recovered the oldest DNA ever found, dating back more than one million years. The achievement marks a milestone in DNA research and shows scientists now have the tools to probe even further back in history than once thought possible.

The DNA comes from the molars of threemammoth specimensfrom the Early and Middle Pleistocene period from northeast Siberia, according to astudypublished Wednesday in the journal Nature. The main goal of the research endeavor was to sequence genomes from before and after the origin and evolution of two other branches of themammothfamily tree, woolly and Columbian mammoths.

Based on the locations of the samples, preserved in permafrost and discovered in the 1970s, they have been named Krestovka, Adycha and Chukochya. The Krestovka mammoth is approximately 1.65 million years old and Adycha is about 1.34 million years old. Chukochya, at about 0.87 million years old, is believed to be one of the earliest knownwoolly mammoths, the scientists said.

Until now, the oldest DNA ever recovered belonged to a horse, dating from 780,000 to 560,000 years ago.

Recovering the mammoths' DNA wasn't easy. "This DNA was extremely degraded into very small pieces, and so we had to sequence many billions of ultra-short DNA sequences, in order to puzzle these genomes together," the study's lead author, Love Daln of the Centre for Palaeogenetics in Stockholm, said during a press briefing Tuesday. "And it has taken quite a lot of effort to do this."

Based on the new specimens, scientists have determined that there were two mammoth lineages in the region during the Early Pleistocene. Adycha and Chukochya come directly from the line that eventually led to the woolly mammoth, while Krestovka represents a previously unknown lineage that researchers propose gave rise to the Columbian mammoth, which inhabited North America during the last Ice Age.

Comparing the genomes of the animals, in addition to their descendants, has shed new light on the evolution of the species over time. There were substantial differences between the molars of Adycha and those of Chukochya and more recent woolly mammoths in terms of enamel thickness, number and density of enamel plates and crown heights, but it is not yet clear to scientists what factors are responsible for the changes.

Researchers hypothesize the Krestovka lineage diverged from the others around 2.66 to 1.78 million years ago, eventually migrating to become the first North American mammoth. They concluded that the origin of the Columbian mammoth represents a "hybrid speciation event" between woolly mammoths and the lineage of Krestovka.

"Because we have this direct ancestral relationship between the really old genomes toward the younger genomes, this allowed us to trace evolution over time, and we could track back when certain adaptions through the Arctic environments possibly have evolved," co-author Tom van der Valk said in the briefing. "And what we found is that many of the adaptations that we know woolly mammoths have, such as thermoregulation, changes in their circadian rhythm, fat deposits and hair growth, were already present" in the million-year-old mammoth.

The ability to extract ancient DNA from the Early Pleistocene will now allow researchers to track changes in lineages across many modern species. They noted the importance of studying permanent frozen environments to further uncover Earth's ancient genetic record.

"Our findings demonstrate that genomic data can be recovered from Early Pleistocene specimens, which opens up the possibility of studying adaptive evolution across speciation events," researchers said. "The mammoth genomes presented here offer a glimpse of this potential."

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Researchers Recover Oldest DNA Ever Found From A Mammoth More Than 1 Million Years Old - News On 6