Monthly Archives: July 2020

Partrac and Team Working on Arklow Bank 2 – Offshore WIND

Posted: July 21, 2020 at 11:59 am

Partrac, MetOceanWorks and Cooper Marine Advisors are carrying out a detailed assessment of the geomorphology of SSE Renewables Arklow Bank Wind Park Phase 2 offshore wind project.

The consortium partners are currently in the second stage of their project, following the completion of the first round of work at the end of 2019.

Last year, the team provided a comprehensive literature review, an initial phase of numerical modelling and recommendations for detailed site investigations, including metocean and geophysical surveys.

Now, in Stage 2, Partrac and partners are utilising the survey data to provide local validation of the modelling tools which will be used to support a long-term assessment of the lease area, export cable route and surrounding areas.

The geomorphological assessment compliments our engineering work streams, allowing us to make decisions with increased knowledge and therefore confidence. We are pleased to be working with the Partrac consortium toward delivery of Stage 2 of this exciting project, said John Davidson, SSE Offshore Geotechnical Engineer.

In mid-July, Partrac informed that it provided metocean survey and consultancy services for three offshore wind projects currently under development in Ireland.

The Arklow Bank Wind Park Phase 2, located off the East Coast of County Wicklow in the Irish Sea, has a consented minimum installed capacity of 520 MW.

The offshore wind farm is planned to be built by 2025.

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Offshore Supply Vessel (OSV) Market Size Technological Advancement And Growth Analysis With Forecast To 2025 – Cole of Duty

Posted: at 11:59 am

Up Market Research (UMR), a prominent market research firm in its own industry, has published a detailed report on Global Offshore Supply Vessel (OSV) Market. This market research report provides comprehensive and in-depth analysis on the market which can possibly help an enterprise to identify lucrative opportunities and assist them with fabricating creative business strategies. The market report provides information about the current market scenario regarding the global supply and demand, key market trends and opportunities in the market, and challenges and threats faced by the industry players.

The Offshore Supply Vessel (OSV) market report talks about the competitive scenario among the industry players and imparts aspiring and emerging industry players with the future market insights in a detailed manner. This market report includes crucial data and figures which are structured out in a concise yet understandable manner. The research report covers the updates on the government regulations and policies which illustrates key opportunities and challenges of the market. Up Market Research (UMR) has been monitoring the market since few years and collaborated with eminent players of the industry to give better insights on the market. It has conducted vigorous research and implied robust methodology to provide accurate predictions about the market.

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Impacts of Advancements and COVID-19 on the market.

Amidst the COVID-19, few segments of the market have witnessed a disruption due to the gap in supply and demand which has impacted the growth of the Offshore Supply Vessel (OSV) market. Along with this, the latest advancements have changed the market dynamics of the market. This research report covers the wide-range analysis of the COVID-19 impact to the industry and gives out insights on the change in the market scenario due to the advancements.

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Market Segmentation

Some of the major companies that are covered in the report.

Edison ChouestTidewaterBourbon OffshoreGulf MarkMaersk Supply ServiceFarstad ShippingHornbeckSwiresDOFDeep Sea SupplyHarvey GulfSeacor MarineSiem OffshoreSolstad OffshoreCoslIsland OffshoreHavilaPACC Offshore Service

Note: Additional companies

Based on the type, the market is segmented into

AHTSPSV

Based on the application, the market is segregated into

Oil and Gas Exploration and ProductionOffshore ConstructionMilitary

Based on the geographical location, the market is segregated into

Asia Pacific: China, Japan, India, and Rest of Asia PacificEurope: Germany, the UK, France, and Rest of EuropeNorth America: The US, Mexico, and CanadaLatin America: Brazil and Rest of Latin AmericaMiddle East & Africa: GCC Countries and Rest of Middle East & Africa

Up Market Research (UMR) provides yearly updates on the Offshore Supply Vessel (OSV) market that assist the clients to stay ahead in the competitive space.

Why one should buy this Offshore Supply Vessel (OSV) Report?

The market research report provides all valuable constituents of the market such as revenue growth, product pricing & analysis, growth potential, and guidelines to tackle the challenges in the market. The report covers all the crucial mergers & acquisitions, partnerships, and collaborations that created further created opportunities or in some cases, challenges for the industry players.

This report includes latest product news, advancements, and updates from the prominent player of the industry that has leveraged their position in the market. It also provides business strategies implemented by the key players and yardstick to arrive on informed business decisions. Moreover, it gives insights on the consumer behavior patterns that can help the enterprise to curate the business strategies accordingly.

Up Market Research (UMR) bestows the clients with the specialized customized options related to the regional analysis, company analysis, and product analysis, among others.

Complete Table Content of the Market

Executive Summary

Assumptions and Acronyms Used

Research Methodology

Offshore Supply Vessel (OSV) Market Overview

Offshore Supply Vessel (OSV) Supply Chain Analysis

Offshore Supply Vessel (OSV) Pricing Analysis

Global Offshore Supply Vessel (OSV) Market Analysis and Forecast by Type

Global Offshore Supply Vessel (OSV) Market Analysis and Forecast by Application

Global Offshore Supply Vessel (OSV) Market Analysis and Forecast by Sales Channel

Global Offshore Supply Vessel (OSV) Market Analysis and Forecast by Region

North America Offshore Supply Vessel (OSV) Market Analysis and Forecast

Latin America Offshore Supply Vessel (OSV) Market Analysis and Forecast

Europe Offshore Supply Vessel (OSV) Market Analysis and Forecast

Asia Pacific Offshore Supply Vessel (OSV) Market Analysis and Forecast

Middle East & Africa Offshore Supply Vessel (OSV) Market Analysis and Forecast

Competition Landscape

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New Road Map for Murphy Administrations Offshore Wind Ambitions – NJ Spotlight

Posted: at 11:59 am

According to the plan, offshore wind will supply 23% of the electricity to customers throughout the state by 2050.

The state has developed a road map for how it will build 7,500 megawatts of offshore wind capacity off the coast within 15 years, a goal the Murphy administration says will help New Jersey become a hub for the fast-growing sector.

The draft Offshore Wind Strategic Plan (OWSP) offers no new major revelations, but instead focuses on a series of priorities the state intends to follow in trying to build a robust offshore wind industry here while protecting its environmental and natural resources, as well as commercial and recreational fisheries.

Offshore wind is viewed as a critical component of the states efforts to combat climate change and seen as key to help grow a green economy in New Jersey and provide thousands of high-paying jobs. By 2050, offshore wind will supply 23% of the electricity to customers throughout the state, according to the 501-page plan.

The development of New Jerseys offshore wind infrastructure will create thousands of high-quality jobs, bring millions of investment dollars to our state, and make our state a global leader in offshore wind development and deployment, Gov. Phil Murphy said in a preamble to the draft plan.

The clean-energy goal, however, has raised concerns among consumer advocates and business groups, who fear the transition to cleaner energy will spike what they view as already steep energy bills for residents and businesses in New Jersey.

The draft plan does not address potential costs in detail, although it acknowledges the upgrading of port facilities around New Jersey to serve the offshore wind sector will require hundreds of millions of dollars in investments.

The goal of the OWSP is to ensure competition, competitive pricing, net economic benefit, environmental and natural resource protection and the overall best value for New Jersey ratepayers, according to the plan.

Nevertheless, it does not offer a rough estimate of what it will take to build out the 7,500 MW offshore capacity and it does not provide associated costs for that process, including the numerous financial incentives mentioned in the draft, the cost of upgrading port facilities, and numerous studies it suggests need to be undertaken to protect natural resources and fisheries.

We support offshore wind, said Dennis Hart, executive director of the Chemistry Industry Council of New Jersey, but at some point, the state Board of Public Utilities has promised its analysis of what it will cost ratepayers. So far, we havent seen anything.

BPU President Joseph Fiordaliso, at the agencys bimonthly meeting on Wednesday, described the draft as providing a comprehensive road map to achieving the goal of 7,500 MW of offshore wind by 2035, while providing the best value to ratepayers.

The draft offers a series of recommendations focusing on five priorities: protection of environmental and natural resources; maintaining viable commercial and recreational fisheries; building a supply chain and training a workforce; identifying potential ports and harbors to serve the sector; and addressing the transmission infrastructure to bring power from the offshore wind farms to residents and businesses.

The latter issue has been controversial with offshore wind developers, so far, opting to build those lines to points on land. Others advocate a so-called backbone transmission system that would allow wind energy to be wheeled up and down the coast. The draft recommends further study on the issue.

The draft suggests two ports will have significant roles in early development of offshore wind the New Jersey Wind Port in Salem County adjacent to the nuclear units there and Paulsboro. They will be especially critical in the rollout of the states first offshore wind farm by rsted 15 miles from Atlantic City. The 1,100 MW Ocean Wind project is not expected to be operating until 2024.

The BPU is expected to seek an additional solicitation for offshore wind projects later this year.

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Torquing Tools for the Offshore Market 2020: Analysis By Regional Outlook, Competitive Landscape, Strategies And Forecasts 2026 – 3rd Watch News

Posted: at 11:59 am

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Segment by Type, the Torquing Tools for the Offshore market is segmented intoElectric Torque WrenchesPneumatic Torque WrenchesHydraulic Torque WrenchesHydraulic Torque PumpsWind Turbine Bolt TensioningHydraulic Bolt Tensioners

Segment by Application, the Torquing Tools for the Offshore market is segmented intoWind EnergyOil and Gas

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Torquing Tools for the Offshore market analysis aside from business, the information, and supply, contact information from manufacturers, consumers and providers can also be presented. Additionally, a feasibility study to asset and SWOT analysis for endeavors have been contained.

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Torquing Tools for the Offshore Market 2020: Analysis By Regional Outlook, Competitive Landscape, Strategies And Forecasts 2026 - 3rd Watch News

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Global Offshore Cable Market 2020: Industry, Size, Share, Demands, Growth, Opportunities, Trends Analysis and Forecast Till 2025:::ABB, Nexans, NKT,…

Posted: at 11:59 am

Trending Offshore Cable Market 2020: COVID-19 Outbreak Impact Analysis

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The Offshore Cable market report 5 Years Forecast [2020-2025] focuses on the COVID19 Outbreak Impact analysis of key points influencing the growth of the market. The intelligence report prepared contains details on the leading players of the Global Offshore Cable Market, along with various depending aspects related and associated with the market. Profile the Top Key Players of Offshore Cable, with sales, revenue and global market share of Offshore Cable are analyzed emphatically by landscape contrast and speak to info. Upstream raw materials and instrumentation and downstream demand analysis is additionally administrated. The Offshore Cable market business development trends and selling channels square measure analyzed. Offshore Cable industry research report enriched on worldwide competition by topmost prime manufactures which providing information such as Company Profiles, Gross, Gross Margin, Capacity, Product Picture and Specification, Production, Price, Cost, Revenue and contact information.The report assesses the key opportunities in the market and outlines the factors that are and will be driving the growth of the Offshore Cableindustry. Growth of the overall Offshore Cablemarket has also been forecasted for the period 2020-2025, taking into consideration the previous growth patterns, the growth drivers and the current and future trends.

>>>>>>This Report Covers Leading Companies Associated in Worldwide Offshore Cable Market: [ ABB, Nexans, NKT, Prysmian, General Cable, Sumitomo Electric Industries, Parker Hannifin, LS Cable & System, TPC Wire & Cable, Fujikura, JDR Cable Systems, Able, Brugg Cables, LEONI, Fujikura ]>>>>>>To know How COVID-19 Pandemic Will Impact This Market/Industry | Request a sample copy of the Offshore Cable Market report:

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The analysis includes market size, upstream situation, market segmentation, market segmentation, price & cost and industry environment. In addition, the report outlines the factors driving industry growth and the description of market channels.The report begins from overview of industrial chain structure, and describes the upstream. Besides, the report analyses market size and forecast in different geographies, type and end-use segment, in addition, the report introduces market competition overview among the major companies and companies profiles, besides, market price and channel features are covered in the report.

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At what rate is the Offshore Cable market expected to grow in size in the forecast period? What are the key factors influencing the global Offshore Cable market growth? Which significant market trends are driving the growth of the global Offshore Cable market? Which factors are the determinants of the market shares of the leading geographies across the globe? Who are the leading participants in the industry and what are the strategies adopted by them in the global Offshore Cable market? What are the opportunities and challenges encounters by vendors in the global Offshore Cable market? Which trends, drivers and challenges are affecting the growth of the industry? What is the outcome of the PESTEL analysis of the global Offshore Cable market?

Analysis of Global Offshore Cable Market: By Type Inter-array CableExport Cable

Analysis of Global Offshore Cable Market: By Application Offshore Wind TurbineOil and Gas Drilling

Offshore Cable Market Regional Analysis Includes:

Asia-Pacific (Vietnam, China, Malaysia, Japan, Philippines, Korea, Thailand, India, Indonesia, and Australia) Europe (Turkey, Germany, Russia UK, Italy, France, etc.) North America (the United States, Mexico, and Canada.) South America (Brazil etc.) The Middle East and Africa (GCC Countries and Egypt.)

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Global Offshore Cable Market 2020: Industry, Size, Share, Demands, Growth, Opportunities, Trends Analysis and Forecast Till 2025:::ABB, Nexans, NKT,...

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RWA: Unlicensed offshore websites pose major threat to responsible gambling in Australia – Gambling Insider – In-depth Analysis for the Gaming…

Posted: at 11:59 am

Responsible Wagering Australia (RWA) has warned that an increase in online gambling poses a major threat to responsible gambling in Australia if fuelled by unlicensed overseas websites.

With various reports of a rise in gambling spending in Australia during the pandemic, the online gambling operator association believes they dont paint the full picture.

Instead, RWA is concerned that much of the online gambling growth has been taken up by unlicensed offshore betting websites, and many people are walking around with an unlicensed casino in their pocket.

RWA CEO Brent Jackson, said: Historical consumer credit data is being used to create alarmist reports that gambling has surged during the COVID crisis.

Without context people assume that increases in online gambling during COVID automatically mean an increase in overall gambling activity. This isnt the industry experience, and credible data sources arent suggesting that either.

Online casinos and pokies operate illegally in Australia despite hundreds of overseas websites being accessible with the click of a button.

While its against the law for businesses to provide these betting games to the Australian market, it isnt actually illegal for Australians to access them, and this puts consumers (including children and vulnerable people) at major risk.

Last month at ICE Asia Digital, Office of Liquor and Gaming Regulation (OLGR) Queensland executive director, Michael Sarquis, said online gambling in Australia grew by 140% during the coronavirus pandemic.

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RWA: Unlicensed offshore websites pose major threat to responsible gambling in Australia - Gambling Insider - In-depth Analysis for the Gaming...

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Consortium in talks to advance Barryroe oil and gas project offshore Ireland – Offshore Oil and Gas Magazine

Posted: at 11:59 am

(Map courtesy Providence Resources)

Offshore staff

DUBLIN, Ireland Providence Resources is in fam-out discussions with SpotOn Energy on exploration license SEL1/11 in the Celtic Sea offshore southern Ireland.

The license includes the Barryroe oil and gas field. SpotOn Energy has confirmed that binding term sheets are now in place with six consortium participants in the fields appraisal and development project, and that it is working with Providence to finalize the work program.

Once agreement has been reached, SpotOn Energy will manage the Barryroe development.

The consortium comprises industry service and supply companies said to hold experience in projects similar to Barryroe, a conventional shallow-water development.

Providence CEO Alan Linn said: Barryroe is one of the largest undeveloped oil and gas fields in Europe When fully developed [it] can provide Ireland with locally produced long-term energy security.

07/20/2020

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Offshore AUV Market ? Key Players, Size, Trends, Growth Opportunities, Analysis and Forecast To 2025 – 3rd Watch News

Posted: at 11:59 am

Up Market Research (UMR) has published a latest market research report on Global Offshore AUV Market. The global report is prepared in collaboration with the leading industry experts and dedicated research analyst team to provide an enterprise with in-depth market insights and help them to take crucial business decisions. This report covers current market trends, opportunities, challenges, and detailed competitive analysis of the industry players in the market.

The published report explains about the current supply and demand scenario and presents the future outlook of the market in a detailed manner. Up Market Research (UMR) has applied a robust market research methodology to bestow the new entrants and emerging players with 360 wide-view analysis on the latest advancements and their impacts on the market. It has congregated massive amount of data on the key segments of the market in an easy to understand format. The research report has laid out the numbers and figures in a comprehensive manner with the help of graphical and pictorial representation which embodies more clarity on the market.

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The on-going pandemic has overhauled various facets of the market. This research report provides the financial impacts and market disturbance on the Offshore AUV market. It also includes analysis on the potential lucrative opportunities and challenges in the foreseeable future. Up Market Research (UMR) has interviewed various delegates of the industry and got involved in the primary and secondary research to confer the clients with information and strategies to fight against the market challenges amidst and after COVID-19 pandemic.

Market Segmentation:

Few of the companies that are covered in the report.

Kongsberg MaritimeOceanServer TechnologyTeledyne GaviaBluefin RoboticsAtlas ElektronikISE LtdJAMSTECECA SASAAB GroupFalmouth ScientificTianjin Sublue

Note: Additional companies can be included in the list upon the request.

By Product Type:

Shallow AUV (depth up to 100 m)Medium AUVs (depth up to 1000 m)Large AUVs (depth more than 1000 m)

By Applications:

DefenseScientific ResearchCommercial

By Geographical Location:Asia Pacific: China, Japan, India, and Rest of Asia PacificEurope: Germany, the UK, France, and Rest of EuropeNorth America: The US, Mexico, and CanadaLatin America: Brazil and Rest of Latin AmericaMiddle East & Africa: GCC Countries and Rest of Middle East & Africa

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Offshore AUV Market ? Key Players, Size, Trends, Growth Opportunities, Analysis and Forecast To 2025 - 3rd Watch News

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Power of DNA to Store Information Gets an Upgrade – UT News – UT News | The University of Texas at Austin

Posted: at 11:58 am

AUSTIN, Texas A team of interdisciplinary researchers hasdiscovered a new technique to store informationin DNA in this case The Wizard of Oz,translatedinto Esperantowith unprecedented accuracy and efficiency. The technique harnesses the information-storage capacity of intertwined strands of DNA to encode and retrieve informationin a way that is both durable and compact.

The technique is described in a paper in this weeksProceedings of the National Academy of Sciences.

The key breakthrough is an encoding algorithm that allows accurate retrieval of the information even when the DNA strands are partially damaged during storage, said Ilya Finkelstein, an associate professor of molecular biosciences and one of the authors of the study.

Humans are creating information at exponentially higher rates than we used to, contributing to the need for a way to store more information efficiently and in a way that will last a long time. Companies such as Google and Microsoft are among those exploring using DNA to store information.

We need a way to store this data so that it is available when and where its needed in a format that will be readable, said Stephen Jones, a research scientist who collaborated on the project with Finkelstein; Bill Press, a professor jointly appointed in computer science and integrative biology; and Ph.D. alumnus John Hawkins. This idea takes advantage of what biology has been doing for billions of years: storing lots of information in a very small space that lasts a long time. DNA doesnt take up much space, it can be stored at room temperature, and it can last for hundreds of thousands of years.

DNA is about 5 million times more efficient than current storage methods. Put another way, a one milliliter droplet of DNA could store the same amount of information as twoWalmartsfull of data servers. And DNA doesnt require permanent cooling and hard disks that are prone to mechanical failures.

Theres just one problem: DNA is prone to errors. And when a genetic code has errors, its a lot different from when a computer code has errors. Errors in computer codes tend to show up as blank spots in the code. Errors in DNA sequences show up as insertions or deletions. The problem there is that when something is deleted or added in DNA, the whole sequence shifts, with no blank spots to alert anyone.

Previously, when information was stored in DNA, the piece of information that needed to be saved, such as a paragraph from a novel, would be repeated 10 to 15 times. When the information was read, the repetitions would be compared to eliminate any insertions or deletions.

We found a way to build the information more like a lattice, Jones said. Each piece of information reinforces other pieces of information. That way, it only needs to be read once.

The language the researchers developed also avoids sections of DNA that are prone to errors or that are difficult to read. The parameters of the language can also change with the type of information that is being stored. For instance, a dropped word in a novel is not as big a deal as a dropped zero in a tax return.

To demonstrate information retrieval from degraded DNA, the team subjected its Wizard of Oz code to high temperatures and extreme humidity. Even though the DNA strands were damaged by these harsh conditions, all the information was still decoded successfully.

We tried to tackle as many problems with the process as we could at the same time, said Hawkins, who recently was with UTs Oden Institute for Computational Engineering and Sciences. What we ended up with is pretty remarkable.

Bill Press is the Warren J. and Viola M. Raymer Professor in Computer Science and Integrative Biology at UT Austin and a member of the National Academy of Sciences. The research was funded by a College of Natural Sciences Catalyst Grant, the Welch Foundation and the National Institutes of Health.

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Messenger of DNA, Therapeutics and Coronavirus: How are they all linked? – PLoS Blogs

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This blog was written by Ashley Chin, BSc, a PhD candidate in the Division of Experimental Medicine at McGill University and Montreal Clinical Research Institute. Her research areas of interest include RNA and cell biology.

The answer lies in RNA. As we may know from the central dogma of molecular biology, RNA is best known as a messenger for DNA. Genetic information is passed on from DNA, to messenger RNA (mRNA), to protein. However, this dogma has led to an overly simplistic view. In the last few decades, scientists have dedicated themselves toward understanding the role that RNA molecules may play beyond being a simple genetic blueprint. They realize that having proper control over these microscopic regulators can translate into macroscopic health benefits in animals, including human. As such, the search for innovative RNA-based therapeutics have set sail.

An Emerging Drug for Mankind

For many years, RNAs have been deemed to be easily degraded and too cumbersome to be manipulated in the laboratory. Any scientists working with RNA would agree with this. This is because the human body is constantly releasing RNases into the environment, enzymes that are used for degrading RNA during normal cellular maintenance and for protecting us against harmful microorganisms. Although this benefit may initially seem like an advantage to you, it has in fact prevented scientists from using RNA as a potential therapeutic for many years, until some recent breakthroughs.

In recent years, RNAs are being explored as a new class of pharmaceutical target and drug, especially as vaccines for neurological disorders and infectious diseases (1-3). For example, to treat children with a crippling neurodegenerative disease called spinal muscular atrophy, building upon the initial RNA research conducted by Adrian Krainer and C. Frank Bennett, who were co-recipients of the 2019 Breakthrough Prize in Life Sciences, one pharmaceutical company and biotech teamed up to harness the power of antisense oligonucleotide therapy, a novel technique whereby carefully modified versions of DNAs are introduced into the cells (1-3). This is achieved by injecting the modified molecules into the fluid surround the spinal cord as a way to alter mRNA splicing, an editing process that is crucial for maintaining genetic information in the cells (1, 3). Additionally, last year, in a study conducted by Feldman and colleagues, they successfully produced effective mRNA vaccines against the influenza A viruses, the mastermind behind seasonal flu every winter. The researchers specifically targeted the H10N8 and H7N9 influenza strains that surfaced in 2013 by producing vaccines that contained chemically modified, full-length forms of those virus mRNAs. The vaccines were given in the deltoid muscle surrounding the shoulder during phase 1 of the clinical trial and yielded promising immune response from healthy participants (4).

What about the pandemic that is currently taking the world by storm paralyzing our daily routines, sinking the global economy and killing countless lives? In fact, much like the mRNA vaccine mentioned above, scientists are working at unprecedented pace to explore the feasibility of using mRNA vaccines to combat SARS-CoV-2, the coronavirus that is causing COVID-19 (5). This is because the traditional form of vaccines we are used to, which usually works by introducing a weakened or dead form of the virus to the body, requires a lengthy manufacturing time. Take the typical seasonal flu shots, an egg-based vaccine, as a more recent example, the virus needs to be first injected into a fertilized chickens eggs, where the selected virus strains incubate and replicate. Following, the viral containing fluids need to be harvested and deactivated before the purified virus antigen can be used in a vaccine (6). With the clock ticking and infection spreading as we speak, any mean to shorten vaccine manufacturing time is lifesaving.

RNA scientists believe mRNA vaccine can be a suitable solution in a time pressed pandemic as the mRNAs can serve as instruction molecules to direct a persons immune system to make their own protein reserve to combat a viral invasion. In this sense, the recipient uses the immune cells within its own body as a manufacturing hub for antibodies, rather than relying on external manufacturing capabilities, which is expected to save time when compared to traditional way of manufacturing vaccines.

In fact, albeit a development in progress, mRNA vaccines have other key advantages over traditional vaccines or DNA-based vaccine. The first and foremost is safety. mRNA is non-infectious, so it will not be integrated into the recipients genome and it can be digested by normal cellular processes. Through various chemical modifications, the longevity of these mRNAs in the body can be controlled. Additionally, the efficiency of mRNA delivery can be increased through designing and packaging the mRNA into protective, carrier molecules, which would enhance stability and encourage rapid uptake by the cells (7). Furthermore, mRNA vaccine can not only be a rapid alternative, but it is also scalable, as it relies on in vitro transcriptions, chemical reactions that are commonly practiced in laboratories, rather than relying on external factors such as the availability of hens eggs in addition to laboratory manipulation (6, 7).

As such, a large mRNA-based biotech is evaluating mRNA-1273 as a putative candidate vaccine for the novel coronavirus (5). The concept surrounding its vaccine is to inject a portion of mRNA that codes for the spike-like protein that is located on the surface of the virus, which allows it to bind to and invade human cells. In this fashion, the synthetic mRNA can travel throughout the bodies of their recipients, stimulating their immune systems to produce beneficial antibodies against the spike protein. Thus, when someone is exposed to the virus, the antibodies will be able to stop an infection by coating spike protein on the virus surface and preventing its capacity to attach to cells. Phase 1 clinical trial consisted of 8 healthy participants and yielded a positive outlook in terms of safety and efficacy. Phase 2, involving a few hundred healthy participants, is currently underway. If all goes well, phase 3 is scheduled to commence in the coming weeks (8).

Similarly, using mRNA-based technology, a pharmaceutical giant has teamed up with another biotech to develop a coronavirus vaccine (5). The most promising vaccine candidate is named mRNA-BNT162b1. This mRNA codes for a receptor binding domain antigen that is found on SARS-CoV-2, a portion of the protein that is required for the virus to bind to human cell. These companies have started phase 1/2 of their clinical trial, which consists of 45 healthy participants. Although some minor but not serious adverse effects were observed, the vaccine generated neutralizing antibodies that are predicted to prevent the coronavirus from operating. In fact, following two administrations of the low doses tested, the concentration of these antibodies were 1.8-2.8 times when compared to recovered patients (9). Nevertheless, whether higher concentration equates to immunity against the coronavirus remains to be tested (9, 10). Phase 2b/3 of the clinical trial is expected to start in few weeks (9).

At this point, due to the inherent complexity of our biological systems and the development of an effective vaccine, only time will tell whether we can effectively fight RNA with RNA. Afterall, this novel coronavirus is an RNA virus and it would be interesting to see if we can give it a taste of its own medicine by using synthetic mRNA molecule to create protein that our own immune systems can learn to combat. This is an exciting era for RNA researchers, as the world anxiously awaits its good news.

Although we have only discussed mRNA vaccines in the context of COVID-19, around the world, there are many other types of vaccine being explored in parallel. With the urgency of this matter, we certainly do not want to put all our eggs in one basket and concurrent vaccine development using a diversity of approaches are warranted.

Perspectives

We are only beginning to understand the many roles that RNAs play in our world. With the rapid technological advances, RNA-based therapies hold great promise for improving modern medicine within the foreseeable future, but much work remains to be done before it can establish itself as an efficient, scalable and go-to clinical solution. It may potentially serve as a great alternative or replacement for gene therapy against certain diseases. This is especially true since mRNA will not integrate into the host genome, minimizing the risk of unpredictable outcome associated with gene therapy.

References

1. Mercuri, E., et al. (2018). Nusinersen versus sham control in later-onset spinal muscular atrophy. N Engl J Med, 378, 625-635.

2. Garde, D. (2018). Researchers behind Biogens breakthrough drug win big at Oscars of science. Statnews. https://www.statnews.com/2018/10/17/researchers-behind-biogens-breakthrough-drug-win-big-at-oscars-of-science/

3. Bennett, C., Krainer, A., & Cleveland, D.W. (2019). Antisense oligonucleotide therapies for neurodegenerative diseases. Annual Review of Neuroscience, 42, 385-406.

4. Feldman, R.A., et al. (2019). mRNA vaccines against H10N8 and N7N9 influenza viruses of pandemic potential are immunogenic and well tolerated in healthy adults in phase 1 randomized clinical trials. Vaccine, 37, 3326-3334.

5. Servick, K. (2020). Meet the company that has just begun testing a coronavirus vaccine in the United States. Sciencemag. https://www.sciencemag.org/news/2017/02/mysterious-2-billion-biotech-revealing-secrets-behind-its-new-drugs-and-vaccines

6. Yeung, J. (2020). The US keeps millions of chickens in secret farms to make flu vaccines. But their eggsw ont work for coronavirus. CNN Health. https://www.cnn.com/2020/03/27/health/chicken-egg-flu-vaccine-intl-hnk-scli/index.html

7. Pardi, N., et al. (2018). mRNA vaccines a new era in vaccinology. Nature Reviews, 17, 261-279.

8. Grady, D. (2020). Moderna coronavirus vaccine trial shows promising early results. The New York Times. https://www.nytimes.com/2020/05/18/health/coronavirus-vaccine-moderna.html

9. Pfizer and BioNTect. (2020). Pfizer and BioNTect announce early positive data from an ongoing phase study of mRNA-based vaccine candidate against SARS-COV-2. Pfizer News. https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-announce-early-positive-data-ongoing-0

10. Herper, M. (2020). Covid-19 vaccine from Pfizer and BioNTect shows positive results. CNBC Newsletters. https://www.cnbc.com/2020/07/01/coronavirus-vaccine-from-pfizer-and-biontech-shows-positive-results-report-says.html

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