Monthly Archives: July 2020

Cleveland Clinic Researchers Identify Genetic Factors that May Influence COVID-19 Susceptibility – Health Essentials from Cleveland Clinic

Posted: July 15, 2020 at 9:55 pm

A new Cleveland Clinic study has identified genetic factors that may influence susceptibility to COVID-19. Published today in BMC Medicine, the study findings could guide personalized treatment for COVID-19.

While the majority of confirmed COVID-19 cases result in mild symptoms, the virus does pose a serious threat to certain individuals. Morbidity and mortality rates rise dramatically with age and co-existing health conditions, such as cancer and cardiovascular disease. However, even young and otherwise healthy individuals have unpredictably experienced severe illness and death. These clinical observations suggest that genetic factors may influence COVID-19 disease susceptibility, but these factors remain largely unknown.

In this new study, a team of researchers led by Feixiong Cheng, Ph.D., of Cleveland Clinics Genomic Medicine Institute, investigated genetic susceptibility to COVID-19 by examining DNA polymorphisms (variations in DNA sequences) in the ACE2 and TMPRSS2 genes. These genes produce enzymes (ACE2 and TMPRSS2, respectively) that enable the virus to enter and infect human cells.

Because we currently have no approved drugs for COVID-19, repurposing already approved drugs could be an efficient and cost-effective approach to developing prevention and treatment strategies, Cheng said. The more we know about the genetic factors influencing COVID-19 susceptibility, the better we will be able to determine the clinical efficacy of potential treatments.

Looking at 81,000 human genomes from three genomic databases, they found 437 genetic variants in the protein-coding regions of ACE2 and TMPRSS2. They identified multiple polymorphisms in both genes that offer potential explanations for different genetic susceptibility to COVID-19 as well as for risk factors.

These findings demonstrate a possible association between ACE2 and TMPRSS2 polymorphisms and COVID-19 susceptibility, indicating that identification of the functional polymorphisms of these variants among different populations could pave the way for precision medicine and personalized treatment strategies for COVID-19.

However, all investigations in this study were performed in general populations, not with COVID-19 patient genetic data. Therefore, Cheng calls for a human genome initiative to validate the teams findings and to identify new clinically actionable variants to accelerate precision medicine for COVID-19.

This study was supported by the National Heart, Lung, and Blood Institute and the National Institute of Aging (both part of the National Institutes of Health) as well as Cleveland Clinics VeloSano Pilot Program. Serpil Erzurum, M.D., chair of Cleveland Clinics Lerner Research Institute, and Charis Eng, M.D., Ph.D., chair of the Genomic Medicine Institute, are co-authors of the study.

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Cleveland Clinic Researchers Identify Genetic Factors that May Influence COVID-19 Susceptibility - Health Essentials from Cleveland Clinic

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Global Genome Editing Market 2019 | How The Industry Will Witness Substantial Growth In The Upcoming Years | Exclusive Report By Market Research…

Posted: at 9:55 pm

Gene editing technologies have an impact across multiple applications areas including plant and animal genetic engineering. However, the area of most disruption is across human cell line engineering, which enables the development of next generations therapies and drugs. However, the agricultural industry has seen more success with gene editing techniques largely due to the less stringent regulatory environment.

You will get latest updated report as per the COVID-19 Impact on this industry. Our updated reports will now feature detailed analysis that will help you make critical decisions.

Browse Full Report: https://www.marketresearchengine.com/upcommingreport/global-genome-editing-market-analysis-by-application-technology-and-end-userforecast-2015-to-2021

This market research report categorizes the genome editing market into the following segments:

The Genome Editing Market is segmented on the lines of Technology, Application, End User and Geographical Region. By Technology this market is segmented on the basis of CRISPR/CAS9, TALENs, ZFNs, Antisense Technology and Other Technologies. By Application this market is segmented on the basis of Cell Line Engineering, Animal Genetic Engineering, Plant Genetic Engineering and Other Applications.

By End User this market is segmented on the basis of Biotechnology and Pharmaceutical Companies sector, Government and Academic Research Institutes sector and Other Research Organizations sectors. By Geographical Region this market is segmented on the basis of North America, Europe, Asia and Rest of the World.

Recent developments across genome editing technologies have resulted in the creation of next generation nucleases that have higher levels of accuracy when correcting genetic mutations and defects. The classes under the genome editing technologies are the 4 broad families of nucleases: ZFNs, TALENs, CRISPR/Cas9, and Mega nucleases.

Global Genome Editing Market is expected to exceed more than US$ 7.5 billion by 2024 at CAGR of 14% in the given forecast period.

The global genome editing market is rapidly increasing due to the increased government funding for genomics technology, rise in the production of genetically modified crops and technological advancements these all factors are driving the growth of this market.

By End User this market is segmented on the basis of Biotechnology and Pharmaceutical Companies sector, Government and Academic Research Institutes sector and Other Research Organizations sectors. By Geographical Region this market is segmented on the basis of North America, Europe, Asia and Rest of the World.

Request Sample Report: https://www.marketresearchengine.com/upcommingreport/global-genome-editing-market-analysis-by-application-technology-and-end-userforecast-2015-to-2021

Table of Contents

1 INTRODUCTION

2 Research Methodology

3 Executive Summary

4 Premium Insights

5 Market Overview

6 Global Genome Editing/Engineering Market, By Technology

7 Global Genome Editing/Genome Engineering Market, By Application

8 Global Genome Editing/Engineering Market, By End User

8.1 Introduction8.2 Biotechnology & Pharmaceutical Companies8.3 Academic & Government Research Institutes8.4 Contract Research Organizations

9 Genome Editing/Genome Engineering Market, By Region

10 Competitive Landscape

11 Company Profiles

11.1 Thermo Fisher Scientific, Inc.

11.2 Merck KGaA

11.3 Horizon Discovery Group PLC

11.4 Genscript USA Inc.

11.5 Sangamo Biosciences, Inc.

11.6 Integrated DNA Technologies, Inc.

11.7 Lonza Group Ltd.

11.8 New England Biolabs, Inc.

11.9 Origene Technologies, Inc.

11.10 Transposagen Biopharmaceuticals, Inc.

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Global Genome Editing Market 2019 | How The Industry Will Witness Substantial Growth In The Upcoming Years | Exclusive Report By Market Research...

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Genetic fingerprints of first COVID19 cases help manage pandemic – News – The University of Sydney

Posted: at 9:55 pm

Genomic sequencing explained

Genomic sequencing creates a genetic fingerprint of organisms and maps the order of how chemical building blocks of a genome are organised.

The researchers looked at how the virus genetic sequence was organised by detecting and translating minute differences in each new infection. A genetic family tree was created showing which COVID-19 positive cases were connected and to track clusters.

The more fingerprints we took, and the critical information collected from the contact tracers, the easier it became to identify if someone contracted COVID-19 from a known cluster or case, said Dr Rockett.

Very early on we were able to discover cases which werent linked to a known cluster or case. This informed state and federal governments that community transmission was happening, and led to the border closures, revision of testing policies and other measures that stopped further spread of the virus.

Dr Rockett and her team managed to produce these genomic data so quickly because they leveraged years of experience in using genome sequencing to track down food-borne pathogens such as salmonella, during food poisoning outbreaks, and transmission of tuberculosis.

The study is a behind the scenes look at the complex and coordinated effort by virologists, bioinformaticians and mathematical modellers alongside clinicians and public health professionals.

Dr Rocketts lab is the dedicated facility hosted by NSW Health Pathology providing genomic sequencing data to NSW Health professionals working at the frontline of managing the pandemic.

Genome sequencing is the key to unlocking the puzzle of local transmission, and its critical that we continue to invest in this research to advance our ability to contain the virus in the long-term not just to trace locally acquired cases, but also to identify new cases once border restrictions are lifted and travel resumes, says Dr Rockett.

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Genetic fingerprints of first COVID19 cases help manage pandemic - News - The University of Sydney

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U of T scientists uncover key process in the manufacture of ribosomes and proteins – News@UofT

Posted: at 9:55 pm

Researchers at the University of Toronto have shown that an enzyme called RNA polymerase (Pol) II drives generation of the building blocks of ribosomes, the molecular machines that manufacture all proteins in cells based on the genetic code.

The discovery reveals a previously unknown function for the enzyme in the nucleolus, the site of ribosome manufacture inside of human cells, where the enzyme had not been seen before. Pol II is one of three RNA polymerases that together enable cells to transfer genetic information from DNA to RNA and then proteins.

Our study redefines the division of labour among the three main RNA polymerases, by identifying Pol II as a major factor in the control of nucleolar organizations underlying protein synthesis, said Karim Mekhail, a professor of laboratory medicine and pathobiology at U of T. It also provides a tool for other researchers to interrogate the function of certain nucleic acid structures more precisely across the genome.

The journal Nature published the results today.

Mekhail and his colleagues found that inside the nucleolus, Pol II enables the expression of ribosomal RNA genes a key step in the creation of ribosomes, essential molecular complexes that make proteins in all cells. Pol II, they showed, generates R-loops hybrid DNA-RNA structures that directly shield ribosomal RNA genes from molecular disruptors called sense intergenic non-coding RNAs (or sincRNAs).

Those disruptors are produced by Pol I in intergenic, non-protein-coding sequences of DNA between genes, and they become more active in various conditions: disruption of Pol II, under environmental stress, and in Ewing sarcoma.

Pol II puts the brakes on Pol I and prevents sincRNAs from sinking the nucleolus, said Mekhail, who holds the Canada Research Chair in Spatial Genome Organization. Thats how we united the name and action of the disruptors in our discussions of this work.

Mekhail and his team developed a new technology to test the function of R-loops at specific locations on chromosomes, which they dubbed the red laser system.

The existing tool in the field would obliterate R-loops across the whole genome, but we wanted to test the function of R-loops associated with a given genetic locus, said Mekhail. We were able to turn an old technology into a modern laser-guided missile, which we are still working to further improve.

Two U of T students were co-lead authors on the study Karan (Josh) Abraham and Negin Khosraviani and Mekhail said they made exceptional and complementary contributions to the research.

Abraham, an MD/PhD student, began work on the project in 2014.

I pursued this work having observed enrichment of Pol II at ribosomal DNA genes in the nucleolus, which was compelling, said Abraham, who will finish his medical training next year. Its incumbent upon every scientist to challenge existing models should the evidence support an alternate one.

A doctoral student who joined the lab in 2018, Khosraviani said teamwork and time management were critical.

We could not have completed this research without the help and dedication of our entire lab. Coordination with local and international collaborators was also essential.

Mekhails team worked with colleagues across U of T and affiliated hospitals on the study, and with international collaborators at the University of Texas at San Antonio and the University of Miami.

Next steps based on this research could include exploration of sincRNAs and nucleolar disorganization as biomarkers for various cancers, and whether tumours with those features respond to drugs that target intergenic Pol I or II.

COVID-19 has been devastating, but other diseases have not stopped, said Mekhail, who temporarily closed his physical lab space during the pandemic but has continued working with his team to analyze and publish results. For example, cancer is still rampant and affecting peoples lives. We have to do what we can and look forward to building on the progress weve made as soon as possible.

This research was supported by the Canadian Institutes of Health Research, Canada Research Chairs, U.S. National Institutes of Health, Ontario Ministry of Research and Innovation, Ontario Graduate Scholarship Program, and Natural Sciences and Engineering Research Council of Canada.

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U of T scientists uncover key process in the manufacture of ribosomes and proteins - News@UofT

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Cardiology Genomic Testing Market Revenue and Value Chain 2018 to 2026 – Cole of Duty

Posted: at 9:55 pm

Latest Study on the Global Cardiology Genomic Testing Market

The recently published report by Transparency Market Research on the global Cardiology Genomic Testing market offers resourceful insights pertaining to the future prospects of the Cardiology Genomic Testing market. The underlying trends, growth opportunities, impeding factors, and glaring market drivers are thoroughly studied in the presented report.

As per the report, the global Cardiology Genomic Testing market is projected to grow at a CAGR of ~XX% and exceed the value of ~US$ towards the end of 2029. Moreover, an in-depth analysis of the micro and macro-economic factors that are anticipated to influence the trajectory of the Cardiology Genomic Testing market during the forecast period (2019-2029) is included in the report.

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Cardiology Genomic Testing Market Segments

Competitive landscape

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Cardiology Genomic Testing Market Revenue and Value Chain 2018 to 2026 - Cole of Duty

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What to know before heading to the Bahamas – Boston Herald

Posted: at 9:54 pm

The Bahamas officially reopened to the public with a handful of new coronavirus guidelines.

When you pack your sunscreen and bathing suit, make sure you have your mask ready as well.

Phase 2 allows for international travel. Earlier this month, the country allowed international boaters, yachters and private aviation as part of Phase 1.

Bring your COVID-19 test: If you plan on visiting the Bahamas, you must present a negative COVID-19 swab test upon arrival. The results must be no more than seven days old.

Youll need a health visa: Travelers will be required to complete an electronic health visa prior to departure and present proof of confirmation at their destination.

Temperature checks: At airports and seaports, all visitors will undergo temperature checks conducted by health care personnel. Any travelers who show COVID-19 symptoms will be transferred to a separate area for further testing and evaluation.

Masks are required: Visitors will be required to wear face masks in any situation where it is necessary to enforce physical distancing guidelines. In addition to airports and sea terminals, travelers must wear masks in taxis, while checking in at hotels, standing in line at attractions and before being seated at restaurants. Failure to comply with the countrys mask guidelines could result in a $200 fine or one month imprisonment.

Flights resume: JetBlue has resumed daily service between Fort Lauderdale, Fla., and Nassau, while American Airlines has resumed flights twice a day between Miami and Nassau.

Curfew in effect: The Bahamas will continue its mandatory curfew from 10 p.m. to 5 a.m., so travelers must return to their housing accommodations during that time. Visitors will be allowed to move freely throughout their hotel and resort properties during curfew.

What about Atlantis: One of the most popular hotels, Atlantis has resumed operations. While the casino slot machines will be open 24/7, table games and sports betting will have revised hours.

Later phases: Beginning Monday, the Bahamas will enter Phase 3 of its reopening, which allows for attractions, excursions and tours to resume. Phase 4, which begins July 27, will allow vendors and jet ski operators to reopen.

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What to know before heading to the Bahamas - Boston Herald

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Government of The Bahamas – Ministry of Health Testing Protocol for Incoming Visitors – PRNewswire

Posted: at 9:54 pm

Update #88

NASSAU, Bahamas, July 9, 2020 /PRNewswire/ -- The Ministry of Health wishes to advise the public that travelers must complete a Bahamas Health Visa application and present a negative COVID-19 RT-PCR test with a sample taken within ten (10) days of arrival.

Effective immediately, all travelers will be required to complete an electronic Bahamas Health Visa application before departure from the place of embarkation. This can be found at travel.gov.bs. Travelers are required to upload a negative COVID-19 RT-PCR test and provide contact information.

The Government of The Bahamas will accept the negative COVID-19 RT-PCR (swab) test if the sample was taken within (10) ten days of arrival. Tests over ten (10) days old will not be accepted.

An automated response will be provided once the application is completed. The only persons approved to travel are those who have received a green color-coded response, as proof of approval. This confirmation must be presented upon arrival in The Bahamas. The Health Visa application process will take twenty-four to forty-eight (24-48) hours and should be completed with adequate lead time.

Failure to comply with the stated requirements will result in denied entry. It is recommended that all travelers interested in visiting The Bahamas review requirements applicable to each member of their traveling party at http://www.bahamas.com/travelupdates before booking a trip.

For more information, or to view the Tourism Readiness and Recovery Plan, please visit http://www.bahamas.com/travelupdates. You may also contact the Ministry of Tourism COVID-19 travel hotline at (242) 502-0829 Monday to Friday, 8 AM 6 PM, or email at [emailprotected].

PRESS INQUIRIESAnita Johnson-PattyBahamas Ministry of Tourism & Aviation[emailprotected]

SOURCE The Bahamas Ministry of Tourism and Aviation

http://www.bahamas.com

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Defense Force increases presence in southern Bahamas – EyeWitness News

Posted: at 9:54 pm

NASSAU, BAHAMAS Minister of National Security Marvin Dames said yesterday the government remains concerned about the threat of undocumented migrants infected with COVID-19 entering The Bahamas illegally.

Dames, who was responding to questions from Eyewitness News, said the defense force has increased its presence in the southern Bahamas and other key entry points.

Last Wednesday, two new cases of COVID-19 were confirmed on Grand Bahama a 20-year-old undocumented migrant and a Grand Bahamian woman.

Eyewitness Newsunderstands the undocumented migrant is a Haitian national, who had been living in Eight Mile Rock since March.

Its something that we are aware of, Dames said.

Every week as a Cabinet we discuss the COVID problem at length.

I think you can see the result of that to date so far. We have been one of those countries throughout the world that have actually been leading in our preventive measures to fight against this pandemic.

He continued: We understand ours is a very porous border. Were an archipelago stretched over some 100,000 square miles of sea and so were on heightened alert.

I just visited with the commodore not too long ago and then had a very good briefing. We have our presence out in the southern Bahamas and those key entry points into our borders. Were not only concerned about [Haiti], were concerned about every country. Were concerned about every citizen, every foreign person coming into this country. We have to ensure and we have put measures in place.

Haiti, which the Pan American Health Organization labeled a humanitarian crisis in relation to the pandemic, has become a COVID-19 hotspot in the Caribbean.

The Bahamas southern neighbor has experienced a large scale outbreak of cases and had more than 13 deaths over a two-day period.

The total death toll was last reported at 139 and there have been nearly 7,000 cases since March 19.

Pressed on the threat of imported cases from undocumented migrants, Dames said: I am certain as I said before, we will look at that as we have been looking at every incident prior to it.

We keep updated charts on trends and whats happening, and how things are happening and what we can do to mitigate and to address, and focus on the issues because at the end of the day we want a nation thats safe from this very, very devastating virus.

We cant afford it to overrun our communities. We cant afford it to inundate our hospitals.

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Top 10 Islands in the Caribbean and the Bahamas – KCTV Kansas City

Posted: at 9:54 pm

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Top 10 Islands in the Caribbean and the Bahamas - KCTV Kansas City

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Bahamas urged to re-examine ‘citizen investors’ – Bahamas Tribune

Posted: at 9:54 pm

By YOURI KEMP

Tribune Business Reporter

ykemp@tribunemedia.net

A Bahamas-based contractor yesterday argued that this nation should re-examine introducing an investor citizenship initiative to help counter COVID-19s negative impact.

Costa Berdanis, Tarcon Constructions president, told Tribune Business that such a scheme would expand the benefits of foreign direct investment (FDI) beyond the real estate sector that is the direct focus of the permanent residency programme.

I think citizenship by investment is one of the things we can do to get some revenue coming in here, he explained. The thing is it is not like we cant put a limit to the number of how many we can invite to do so, and we can screen who we want.

We have an attractive system here. We have a good banking system that a lot of Caribbean countries dont have, which is first world banking, and a lot of people are more attracted to come here.

Mr Berdanis continued: Right now we have a residency programme for $750,000 that is solely linked to real estate, so the benefit doesnt really trickle down to everybody.

If you had a citizenship programme to rebuild the country, a person would come in and make a donation. Out of that $750,000, lets say $300,000 went to rebuild schools and roads, and the other $450,000 went to helping combat the coronavirus, help the National Insurance Board and some of the national issues - all of the things that would benefit the majority of the people rather than the minority.

I think this is a viable thing, but I know the United States doesnt like us selling our citizenship. But, at the end of the day, we have to take care of ourselves here and it is a thing that people want and we can limit it.

So-called Investor Citizenship initiatives have been mulled and floated in the past, most recently by Sean McWeeney QC, a former attorney general and key advisor to ex-premier Perry Christie. The idea was ruled out, though, by both that administration and the current government, with ex-financial services minister, Brent Symonette, placing the focus on speeding up permanent residency applications.

Investor Citizenship would grant citizenship to a limited group of individuals, once they met certain criteria, including a high multi-million dollar investment threshold. Those qualifying would have to invest in Bahamas-based developments and companies that created local jobs, with the initiative targeted at a small group of billionaires and multi-millionaires with the resources to move the economy.

The programme would essentially be targeted at the worlds wealthiest individuals, meaning the likes of Joe Lewis and the Izmirlian families. The billionaires, both of whom reside at Lyford Cay, have ultimately invested billions in the domestic economy, and created thousands of local jobs, via Albany and Baha Mar respectively (notwithstanding subsequent events at the latter).

Investor citizenship programmes have been adopted by countries such as Grenada, Antigua and Barbuda, Malta, the Netherlands, the UK and Spain, either allowing direct citizenship by investment or offering routes to citizenship for wealthy investors.

Concerns have been raised, however, over the transparency and accountability surrounding such programmes, which have also drawn the attention of regulators and law enforcement agencies in nations such as the US on the grounds that citizenship is being bought.

However, Mr Berdanis added: I have a lawyer friend right now in Canada who has millions of dollars from persons bundled up that just want to get residency, and they dont want residency for criminal reasons.

Lets say that these people are right now in Hong Kong, and they may be worth up to $3m or more. They want to have a back-up plan if China further puts a clamp down on them. I know there are a few groups that are pushing the Government on this citizenship by investment initiative, as there are a few Canadian firms that are inquiring and I think a couple of law firms are.

Mr Berdanis added: From the immigration aspect, we can benefit from it greatly. Portugal is benefiting, and a friend of mine has built 16 high-rise hotels for people that are making investments. Once they get a group like Hyatt or the Marriott, they would have the management to give these hotel brands a return, and those folks dont even occupy those places as they just get their residency. If they need a place they can go to have an escape, they have it.

Mr Beranis ultimately said he doesnt see a downside to it here, adding that the Government can always experiment with the initiative. He added that The Bahamas dont have to go huge, but if you give out 1,000 citizenship by investment certificates you can spread it out among all of the lawyers so they can equally have the business.

We have so many undeveloped islands that we can do private residency on if you are concerned about these people living amongst us on New Providence. Diversification has always been a good thing. We have so many empty islands that we can experiment with but they just dont touch them.

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Bahamas urged to re-examine 'citizen investors' - Bahamas Tribune

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