Daily Archives: November 15, 2019

Final euthanasia bill reading begins in Parliament – RNZ

Posted: November 15, 2019 at 1:46 pm

The third and final reading of the End of Life Choice Bill has been passed in Parliament by 69 votes to 51.

Protesters against the Euthanasia Bill gather outside Parliament. Photo: RNZ / Dom Thomas

The member's bill, in the name of ACT leader David Seymour, allows terminally ill adults to request a medically-assisted death.

It cleared its second reading 70 votes to 50 in June and easily passed tonight after impassioned debate.

However, it will still take a majority referendum result at next year's General Election before the legislation can be enacted.

There were passionate speeches both for and against the bill and holding a referendum.

Of those opposed, National MP Chris Penk warned against the bill going to a public poll.

"Is it responsible for us as lawmakers to hand a loaded gun to fellow New Zealanders and say 'don't worry I have applied the safety catch?', knowing very well that for many New Zealanders the only words of the bill they will ever read before such a referendum will be the title of the bill," he said.

Mr Penk told the house polling showed 70 percent of the public, believed the bill concerns itself with orders not to resuscitate, which are already legal.

He added 74 percent thought to switch off life support is within the remit of the bill.

But New Zealand First MP Tracey Martin defended the bill going to a referendum.

"Because it is such an unusual topic of such a momentous decision for New Zealand we agree that it is right and proper our consciences, which I hear the words of others who talk about the tyranny of the majority, surely this would be the dictatorship of the minority."

Ms Martin told the house the New Zealand public voted MPs to Parliament on party manifestos rather than their individual consciences.

On the front lawn of Parliament this afternoon a protest group of a few hundred people brandished signs opposing the legislation - "caring not killing", and referring to the Bill's "weak safeguards".

Protesters against the Euthanasia Bill gather outside Parliament. Photo: RNZ / Dom Thomas

Labour list MP Jamie Strange told the crowd MPs from across the House would support them in their opposition.

National's Alfred Ngaro, a list MP, told them the Bill was going ahead despite the direct opposition of thousands of New Zealanders, including some in the medical community - "still, here we are today".

He encouraged them to "keep the faith because there are those who believe that this is wrong".

National MP Dr Shane Reti had asked the House, as a medical practitioner and a Mori, to vote against the end of Life Choice Bill.

Shane Reti had said the bill would change the very fabric of the doctor-patient relationship.

Before the vote, Mr Seymour had said he was "quietly confident" the Bill would pass, but would continue working for votes up to the last minute.

"We've had the arguments - I don't think anyone will ever be able to say that Parliament didn't properly scrutinise this bill," he said.

"It's been nearly two years since the parliamentary process started. And over that time we've kicked around every conceivable argument for and against the bill."

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Final euthanasia bill reading begins in Parliament - RNZ

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Quickfire: MPs give their view on vaping, euthanasia and recycling labels – TVNZ

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Quickfire: Inside Parliamentputs politicians from different sides of the House together, asking for their views about the biggest current news stories.

1 NEWS Now's Anna Whyte put the questions to National Party's Mark Mitchell and Labour's Meka Whaitiri.

One of the new Warriors' jersey for the 2020 NRL season has come under fire are you a fan?

Is there anything you dabbled with or tried before health issues came up later?

Green MP Chloe Swarbrick said OK boomer in the House recently, whats the funniest/weirdest comment youve been called in the House (or called someone else)?.

A major overhaul of New Zealands school system is on the way, resetting the governance, management and administration of the way schools are run. Prior to this, do you think school boards had too much power?

The Government are asking the public their view on human rights versus community safety when it comes to Firearm Prohibition Orders what do you think?

Is violence against women a major problem in New Zealand?

Will the new partySustainable NZcross the 5 per cent threshold line?

Watch the answers in the video above.

Previous Quickfire episodes:

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We ask MPs for their views about the biggest current news stories. Source: 1 NEWS

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Labours Andrew Little and Nationals Christopher Bishop discuss the biggest news stories. Source: 1 NEWS

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This week we put the questions to National Party's Chris Penk and Labour MP Ginny Andersen. Source: 1 NEWS

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We ask the MPs about the biggest news stories of the week. Source: 1 NEWS

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Quickfire: MPs give their view on vaping, euthanasia and recycling labels - TVNZ

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Voters may be overwhelmed by cannabis, euthanasia referendums at election – analyst – TVNZ

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A political communications analyst says voters may be overwhelmed by the prospect of two referendums and a general election at the same time next year.

As well as deciding the make-up of the next government, voters will be asked to say whether recreational cannabis use should be legalised and - after yesterday's vote in Parliament - whether voluntary euthanasia should be legal.

Claire Robinson, a political communications analyst at Massey University, said there is a risk that the campaigning on such contentious issues could swamp people.

She said voters find it difficult enough to pay attention to a general election let alone to make decisions on two major issues at the same time.

"I suspect the news media will focus a lot more on the referendum questions because they are actually really interesting and are potentially going to change New Zealand significantly after the referendums."

However, Professor Robinson said it is possible voters may pay more attention to the decision they make instead of the election vote, which could be overshadowed.

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Kiwis may soon be able to grow the plant legally in their own backyards. Source: 1 NEWS

"Normally people will vote on habit, if you have always voted for the Labour Party or the National Party or whoever, then it is easy enough just to follow that pattern, but with these two issues there is not many signals you can fall back on.

"People will actually stop and pay attention to the information that they get."

She said whether the information is good or not is another matter.

"There is no guarantee of the quality of the information that they receive and I think voters will look to reputable providers like the news media, which will be providing good balanced information on both sides."

Some of Professor Robinson's team at Massey University is putting together an online tool to help people make good decisions around the cannabis referendum.

"I'm not sure what is going to be out there on the End of Life Choice.

"David Seymour said ordinary New Zealanders' life experiences is simply enough to make them informed, I'm not sure that that necessarily is going to equate to informing people sufficiently on how to vote."

Professor Robinson said turnout is likely to be higher due to the referendums sparking more interest.

"It's a good idea to combine them. The trouble is it is just such a lot of information for people to have to absorb."

She said if there were done at a different time, then turnout would be lower, probably round about a 40-per cent turnout.

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Voters may be overwhelmed by cannabis, euthanasia referendums at election - analyst - TVNZ

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DHS Sued for Answers About Its Use of DNA Testing at the Border – Newsweek

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A privacy rights group is suing the Department of Homeland Security (DHS) for answers about its use of Rapid DNA technology on migrant families at the U.S.-Mexico border.

The Electronic Frontier Foundation (EFF) filed a Freedom of Information Act complaint in federal court in San Francisco earlier this week, asking a judge to force the DHS to share information on its use of Rapid DNA testing.

The complaint highlights how little the DHS has so far shared about its use of DNA testing at the border.

The EFF has demanded to know how many people, including children have had their DNA collected at the border, how accurate the DNA tests are, as well as what exact gene processing is being used to identify parent-child relationships.

The lawsuit also asks the DHS to hand over its training materials, consent forms and a sample of the privacy statements families are being given, in addition to demanding to know the locations of DHS's Rapid DNA pilot programs.

The bid to obtain more information about the program comes months after the DHS started using Rapid DNA testing on adults and children presenting themselves at the U.S. border.

The department had sought to use the program to identify "fraudulent" families, or adults and children who were not biologically related, but presenting as families at the border.

However, the EFF has argued that it has done so with little oversight and without sharing enough information about its process or how the program is being expanded.

"Congress has never authorized ICE to conduct Rapid DNA testing on migrant families at the border, yet DHS has deployed this privacy-invasive technology without explaining how accurate the testing is, whether families can challenge the results, or how the program may be expanded in the future," said EFF Staff Attorney Saira Hussain in a statement shared in a press release.

The organization's complaint comes amid a DHS proposal to expand the collection of DNA of detained migrants and store that information in a federal criminal database.

Already the DHS has gained widespread condemnation over that plan. The American Civil Liberties Union (ACLU) and thousands of supporters have urged the Trump administration to abandon the plan, with thousands of public comments filed in the Federal Register.

"This unjustifiable step towards full population surveillance threatens to subvert our foundational values of freedom, autonomy, and presumed innocence," said Vera Eidelman, staff attorney with the ACLU's Speech, Privacy, and Technology Project in a statement shared with Newsweek.

"Under this dehumanizing plan, immigrants who already have no control over their movements, their health, or their futures would also lose control over their genetic blueprints," Eidelman said. "The administration should heed the calls of the thousands of people demanding it abandon this dangerous and xenophobic plan."

Newsweek has contacted the DHS for comment for this article.

The graphic below, provided by Statista, illustrates the spike in the number of family units detained at the southern border.

This article was updated to include an infographic.

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Researchers Find More Than 1 Million Alternatives to DNA – ExtremeTech

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Life on Earth uses DNA and RNA to store and utilize genetic information, but what if theres another way? A new analysis from researchers at Emory University and the Tokyo Institute of Technology suggests a plethora of molecules could serve the same basic task of organizing and storing genetic information. They estimate more than a million possible stand-ins for DNA, some of which could help us fight disease or help us know what to expect as we search for alien life.

DNA (and RNA) consist of several components that make up the familiar double helix. There are the base pairs like adenine and guanine, a sugar (deoxyribose for DNA and ribose for RNA), and a phosphate group. The sugar and phosphate give nucleic acid an alternating sugar-phosphate backbone. We already know there are many alternatives to the five bases at work in DNA and RNA on Earth, but the new study looks at how the scaffolding of nucleic acid could vary.

The team used a computer simulation to explore a so-called chemical space within certain constraints. To choose the constraints, the team had to distill what makes nucleic acid molecules distinct. They settled on organic molecules that can assemble into a linear polymer with at least two attachment points, plus a place for nitrogen bases to connect. The substructure of the molecule also needs to be stable in a polymer configuration. Since these molecules dont contain the traditional sugars and phosphorus, you cant call them DNA theyre some other kind of nucleic acid with potentially similar properties.

A few alternate nucleic acids.

The analysis points to more than 1,160,000 potential nucleic acid molecules. That number exceeded even the most extreme estimates beforehand, but researchers can now start looking at these molecules in a laboratory setting to see if they can work as a DNA alternative. The team says this shows evolution on Earth may have experimented with several different molecular designs for storing genetic information before DNA ultimately won out.

Researchers around the world are working on therapeutic drugs that resemble nucleic acid, some of which could help combat viruses and cancer. A better understanding of these DNA alternatives could make those treatments more effective. And then theres the importance to exobiology research. If were looking for evidence of extraterrestrial life, it might help to remember they could have genetic material using one of the other million possible molecules.

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This wristband tells you what food to buy based on your DNA – World Economic Forum

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When an undiagnosed rare genetic disease caused his young sons kidneys to fail, Professor Chris Toumazou vowed to find a way of uncovering hidden health risks.

The professor of biomedical engineering realised that, although his sons condition could not have been prevented, the family could have managed his lifestyle very differently had they known about his condition.

So, he embarked on a mission to help people change their lifestyles and avoid getting sick.

Lifestyle, he says, has a huge impact on many undiagnosed conditions such as diabetes and high blood pressure. Changing behaviour could save lives.

The result of his research is a simple wristband that uses your DNA to help you make healthy choices as you shop for groceries.

By analysing the part of your genetic code determining susceptibility to nutrition-related health conditions like diabetes, DNANudge tells you which foods are best for you, and which you should avoid.

DNANudge analyses your genetic code and tells you which foods are best for you, and which you should avoid.

Image: DNANudge

The wristband scans shop barcodes and shows a green light if a product is OK and red if it may be harmful in the long run. The wristband's linked smartphone app suggests healthier alternatives when the red light comes on.

Following his sons acute illness, Toumazou also invented a microchip that can read an individuals DNA from a simple mouth swab sample. Its now used to upload a DNA profile to the new wristband a process that takes an hour instead of up to eight weeks for a conventional DNA test.

"We're not telling people they can't eat biscuits, that they should eat grapes. No, they can eat biscuits, but eat the better biscuits based upon your DNA and lifestyle," says Toumazou.

"It's using biology to nudge and guide you to have a healthier lifestyle in the long term."

The World Economic Forum was the first to draw the worlds attention to the Fourth Industrial Revolution, the current period of unprecedented change driven by rapid technological advances. Policies, norms and regulations have not been able to keep up with the pace of innovation, creating a growing need to fill this gap.

The Forum established the Centre for the Fourth Industrial Revolution Network in 2017 to ensure that new and emerging technologies will helpnot harmhumanity in the future. Headquartered in San Francisco, the network launched centres in China, India and Japan in 2018 and is rapidly establishing locally-run Affiliate Centres in many countries around the world.

The global network is working closely with partners from government, business, academia and civil society to co-design and pilot agile frameworks for governing new and emerging technologies, including artificial intelligence (AI), autonomous vehicles, blockchain, data policy, digital trade, drones, internet of things (IoT), precision medicine and environmental innovations.

Learn more about the groundbreaking work that the Centre for the Fourth Industrial Revolution Network is doing to prepare us for the future.

Want to help us shape the Fourth Industrial Revolution? Contact us to find out how you can become a member or partner.

The device also helps to promote overall health by warning if you are inactive for too long. An orange light means it's time to get up and move about.

One in 10 people with pre-diabetes, a reversible condition, will go on to develop type 2 diabetes, which affects more than 400 million people worldwide. Early diagnosis can enable people to change their lifestyles and avoid developing the full-blown condition.

And what about Toumazous son Marcus? Well, his story has a happy ending. After months in dialysis he received a kidney transplant and is now in good health.

He even met the Queen at the opening of his fathers new lab in London. He told her his father was changing healthcare by making microchips for the human body.

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The views expressed in this article are those of the author alone and not the World Economic Forum.

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The Dawn of Cheap and Easy DNA Writing – NEO.LIFE

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The 4,000-square-foot suite, tucked into a small office park in the heart of San Diegos biotech corridor, is about as small and unassuming as a university biology-lab classroom. But the 16 people who work here at Molecular Assemblies are chasing a goal that could revolutionize synthetic biology: the ability to write DNA molecules using enzymes.

The field of synthetic biology has, for years, been promising the ability to custom-design organisms that serve as everything from new antibiotics to plastic eaters. But despite substantial advances in both sequencing and editing DNA, one of the big holdups in fulfilling this potential is that whipping up DNA to order is slow andespecially for long moleculesexpensive. In truth, the way scientists write DNA hasnt changed much since the process was first developed in 1981. Its slow, laborious, and environmentally hazardous.

But several startup companies believe they can do it cheaper, faster, and more accurately with a new method. They believe that using enzymes, which is how DNA is written in nature, is the way to go.

Molecular Assemblies recently raised $12.2 million in an initial round of funding, though its far from alone in its quest to use enzymes for building DNA. At least seven startups are trying to do it. Researchers at the University of California at Berkeley, who have published the only paper so far to describe a successful enzymatic approach, founded Ansa Biotechnologies to commercialize it. Ansa, like Molecular Assemblies, is building its business model around providing DNA to customers who send in orders. But another contender, DNA Script, recently announced $38.5 million in a second round of funding for a benchtop machine that would enable labs and hospitals to build DNA themselves.

Today, commercially available DNA synthesis uses a process called phosphoramidite chemistry, which relies on toxic, flammable reagents that create hazardous waste. The process has important limitationsmost companies that build DNA this way top off at lengths of about 100 to 150 base pairs, which isnt even as long as many genes, and the harsh chemistry involved in adding each A, G, C, or T can start to degrade the already-written part as the molecule grows longer. This method also produces molecules that arent compatible with water-based biology. Thats acceptable if you want to use DNA as a form of data storage, but to be useful in biological applications, DNA made through phosphoramidite chemistry has to be put through additional processing, which increases the cost.

Its amazing that they get chemical synthesis of DNA to work, says Andrew Hessel, president of Humane Genomics, which is developing new cancer therapies by reprogramming viruses, and co-founder of Genome Project-write. GP-write, as its known, an international effort to explore the prospects of redesigning human cells, just concluded its annual meeting in New York City. The reality is that nature uses enzymes to write DNA, and that is an incredibly complex process. Every time a cell in your body divides, it has to write a whole human genome perfectly without any additional modifications.

As synthetic biology advances, researchers want longer and longer segments of DNAideally, at least the length of genes. The longer the DNA molecule, the fewer the segments that scientists have to stitch together to make a desired sequence, which should reduce the cost and the chances for errors to be introduced.

Those involved in Hessels GP-write project have their sights set on writing full genomes, which would allow them to engineer human cells (and other organisms cells) so as to better understand health and disease. For example, some scientists involved in GP-write are exploring ways of making cells resistant to viruses. Others are investigating how cells could produce essential nutrients that people now have to derive from food. But making genome-length DNAeven bacterial genomesusing chemical synthesis is currently cost-prohibitive.

William Efcavitch, chief science officer and co-founder of Molecular Assemblies, helped lead the development and commercialization of the original phosphoramidite method in the early 1980s, but now he says its clear a better approach is required. Rather than trying to push 35-year-old chemistry to make longer strands, we said: Lets start with an enzymatic process that can already make long strands and teach it to do it in a user-friendly fashion, says Efcavitch.

You have to control the enzyme and tell it what to write. And thats tricky.

The challenge is that in their natural habitat within a cell, enzymes dont create DNA from scratch. Instead, they duplicate a pre-existing strand by pulling nucleic acids, one by one, to the growing molecule. So Molecular Assemblies and most of the other companies have turned to the only enzyme known to build DNA without a template. This DNA-creating enzyme, or polymerase, is called terminal deoxynucleotidyl transferase (TdT). Typically found in vertebrate immune cells, it is responsible for building the new and ever-changing antigen receptors a cell needs to fight unfamiliar viruses and bacteria.

TdT evolved to make long strands of DNA in a random fashion, but the new breed of DNA-writing startups think they can program it. All of them, however, are still working to figure out exactly how. The challenge with enzymatic synthesis from scratch is that you have to control the enzyme and tell it what to write, Hessel says. And thats tricky.

Chemical synthesis uses a computer to control a system that adds A, G, C, or Tone drop at a timein a four-step process: The DNA molecule is extended by one nucleotide held in place with an unstable bond; then the incomplete end is capped off; then the newly linked nucleotide is stabilized; and then the molecule is prepared for the next addition. Enzymatic synthesis eliminates two of those steps: the polymerase just needs to be stopped and started for each additional nucleotide. Right now, Efcavitch says, were trying to optimize those two steps.

The enzymatic synthesis startups have shown modest success. Ansa has built short DNA fragments called oligonucleotides (or oligos) of 50 base pairs. DNA Script has hit 200, and another companyCamena Biosciencerecently announced it had reached 300. Molecular Assemblies wont specify how long its oligos have gotten other than to say they havent yet reached 150.

The companies claims remain largely untested by the synthetic biology community.

There have been almost no publications, says Calin Plesa, a synthetic biology researcherat the University of Oregon. Its been very difficult to know whats beengoing on inside these companies.

Plesa himself is a heavy user of synthetic DNA for building DNA libraries, as is Sri Kosuri, a synthetic biologist at the University of California, Los Angeles, and co-founder of a startup called Octant. Kosuri describes himself as a synthetic DNA addict whose lab consumes large amounts of oligonucleotides to explore the relationship between DNA sequences and their functions. He appreciates how the companies pursuing enzymatic DNA synthesis are trying to improve the accuracy of the technology. Accuracy is an issue. Its what limits even our own work, Kosuri says. But he adds that it doesnt yet appear that the DNA-writing startups have gotten the enzymatic process near the accuracy of phosphoramidite chemistry.

George Church, a geneticist at Harvard University who is a cofounder of both the Human Genome Project and GP-write, says chemical DNA synthesis methods generally induce an error every 1 in 300 bases. Error-correction methods can improve the figure to 1 in 10,000. When enzymes naturally copy a strand of DNA in cells, however, the error rate is close to one in a billion. But he agrees with Kosuri that no enyzmatic synthesis company has come even close to such low error rates. Right now, theres no evidence than enzymatics is more accurate [than chemical synthesis]. I think its likely but not proven, Church says.

Today, the longest oligonucleotides being produced are coming out of South San Francisco-based Twist Bioscience, which has miniaturized the chemistry using a silicon chip with thousands of tiny wells, creating a platform that that can make one million oligos simultaneously. They are used for screening, diagnostics, therapeutics, and genetic research. Twist can now make oligos up to 300 base pairs long in these wells, more than twice what most enzymatic companies are capable of at the moment.

But Twist Bioscience CEO Emily Leproust saysthat if a better method of synthesizing DNA presents itself, Twists method canaccommodate it. We dont really have a dog in the fight, she says. If thereis better [synthesis through] enzyme chemistry, Ill be the first customer. Oncethe approach reaches one of any number of milestoneslonger, fewer errors, orfaster productionshed be on board. Ill take cheaper but frankly Ill paymore if its faster or better or longer.

Shes confident that one or more of the companies pursingthe enzymatic approach will hit the target eventually. I dont think they haveto break any rule of physics to get thereI think its just engineering, shesays. Its a question of how much money do you need, and how much time do youneed, and can you recoup that investment in commercialization.

Church and Hessel both agree that enzymatic synthesis will start to gain traction soon. I fully expect that bacterial-scale genomes will be within anyones reach within the next 10 years, Hessel says. And that would be just the start. I dont think weve started to unlock the possibilities here. I cant wait to see how these tools and technologies change the world.

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Never could have dreamed this: DNA ancestry test kit leads Wanda Starke on journey to find sister – WXII12 Winston-Salem

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The quest began with a white box containing a tube and collection bag.The directions were simple. Fill the tube with saliva to the black wavy line, then replace the funnel on the tube with the blue liquid cap before you tighten to release the fluid and shake.Three weeks later, the results were in from Ancestry DNA.The first thing I saw was my DNA story, the so called "ethnicity estimate," a breakdown of where my ancestors came from.It estimated that 80 percent came from Africa, primarily Benin Togo, Camerooon and Ghana. The other 20 percent came from Europe, mainly England and Wales.The next page I looked at were DNA matches. There are 865 people identified as fourth cousins or closer, and a woman named Constance was at the top of the list.But who was Constance and how was she related to me?One clue: My biological father also appeared in her family tree.The problem was I didn't know anything about my biological father except that his name was Algie. My birth mother shared that information in 2007, six months before she died.I didn't know what to do next, so I called a cousin.Matt and I were both adopted. Our birth mothers are sisters. He suggested I call a cousin on his dad's side who knows a lot of people.Raymond didn't know Constance. But he knew Algie quite well. "Algie lived within walking distance of where I actually grew up," Raymond said. "We looked up to him because he was so suave,debonair. He owned his own cab company."Raymond offered to tell Algie's family, and soon I got a call from her sister Gwen. When I asked if she knew a Constance, she was quiet until she said, "Oh-Connie-our half sister."There were more calls and texts, this time from Connie herself. And just two weeks after our first conversation, I was on the road to Maryland to meet her in person.It felt so surreal and yet so normal. We were two sisters just being sisters.We shared stories over food and wine like we had known each other our whole lives.There was so much to talk about and so little time, but it wasn't long before Connie and her husband, Roland, came to Winston-Salem for the National Black Theatre Festival."I love you, and the more Im around you the deeper it gets," Connie told me.I could never have imagined that I would get a gift so wonderful and large at this stage of my life. I never could have dreamed this.

The quest began with a white box containing a tube and collection bag.

The directions were simple. Fill the tube with saliva to the black wavy line, then replace the funnel on the tube with the blue liquid cap before you tighten to release the fluid and shake.

Three weeks later, the results were in from Ancestry DNA.

The first thing I saw was my DNA story, the so called "ethnicity estimate," a breakdown of where my ancestors came from.

It estimated that 80 percent came from Africa, primarily Benin Togo, Camerooon and Ghana. The other 20 percent came from Europe, mainly England and Wales.

The next page I looked at were DNA matches. There are 865 people identified as fourth cousins or closer, and a woman named Constance was at the top of the list.

But who was Constance and how was she related to me?

One clue: My biological father also appeared in her family tree.

The problem was I didn't know anything about my biological father except that his name was Algie. My birth mother shared that information in 2007, six months before she died.

I didn't know what to do next, so I called a cousin.

Matt and I were both adopted. Our birth mothers are sisters. He suggested I call a cousin on his dad's side who knows a lot of people.

Raymond didn't know Constance. But he knew Algie quite well.

"Algie lived within walking distance of where I actually grew up," Raymond said. "We looked up to him because he was so suave,debonair. He owned his own cab company."

Raymond offered to tell Algie's family, and soon I got a call from her sister Gwen. When I asked if she knew a Constance, she was quiet until she said, "Oh-Connie-our half sister."

There were more calls and texts, this time from Connie herself. And just two weeks after our first conversation, I was on the road to Maryland to meet her in person.

It felt so surreal and yet so normal. We were two sisters just being sisters.

We shared stories over food and wine like we had known each other our whole lives.

There was so much to talk about and so little time, but it wasn't long before Connie and her husband, Roland, came to Winston-Salem for the National Black Theatre Festival.

"I love you, and the more Im around you the deeper it gets," Connie told me.

I could never have imagined that I would get a gift so wonderful and large at this stage of my life. I never could have dreamed this.

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Never could have dreamed this: DNA ancestry test kit leads Wanda Starke on journey to find sister - WXII12 Winston-Salem

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Ant and Decs DNA test merely tells us that were all inbred – The Guardian

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After watching Ant & Decs DNA Journey on ITV, I can confidently say that one thing it failed to do for me and which genetics could definitively answer is clarify which one is Ant and which one is Dec. Alas, this mystery remains unsolved.

Aside from that, the documentary is entertaining enough. In the first episode, Ant and Dec travel around, talking to genealogists and distant relatives who have been identified by having similar bits of DNA to them like Who Do You Think You Are? but with bonus genetics. We are introduced to Dixie Carter, who is described as a genetic cousin to Dec, though I couldnt tell precisely what relation she is. The two shared an ancestor from around 150 years ago, and her presence provides light relief as she is a Texan wrestling promoter.

It is, of course, incumbent on science to spoil the fun. A common ancestor six generations into the past, like the one shared between Dixie and Dec, is one of 64 great-great-great-great-grandparents you have. Maybe Dixie was simply the most exciting relative the producers found. Without DNA analysis, the Geordie duo would not have traced her and other distant relatives, but the truth is that there is very little meaningful genetic relationship there.

Geneticists did not anticipate that the human genome would become such a saleable commodity. Its estimated that more than 26m commercial genetic tests have been taken worldwide, mainly trading on the beguiling promise of revealing something about your ancestry.

The show is sponsored by the biggest of these companies, Ancestry, who are credible, and whose data your data is put to interesting use, such as producing scientific papers that analyse the genetic structure of modern Americans. Also in the programme were Alistair Moffat and Jim Wilson, founders of another, now defunct, company called BritainsDNA, which made headlines for some absurd and ahistorical claims over the years, including saying that it had traced the descendants of the Queen of Sheba (a Biblical character who may or may not have existed) and those of Eve, sticking with the Biblical theme. It was even behind claims that climate change would make ginger people extinct.

In 2012, Moffat threatened legal action against geneticists at UCL (to which I am affiliated) who had criticised some of the companys claims. A paper in the peer-reviewed journal Genealogy documents this saga and the way BritainsDNA made a number of dubious claims both directly to its customers and in the media. Companies like that devalue the business of genetic genealogy, so it is troubling to see its key players Moffat effectively introduces the show feature so prominently in Ant and Decs show.

The marketing ploy of the genetics industry is to tell stories of belonging. This can be powerful because everyone craves autobiographical meaning. But the power of genetics to deliver narrative satisfaction is profoundly limited. All genetic genealogy companies play upon this to a certain extent. California-based 23andMe capitalised on the 2018 football World Cup finals with adverts suggesting you should root for your roots by supporting the countries that reflect your unique DNA, thus indicating that their marketing department clearly have no idea about football fandom.

Family trees may be the ties that bind us, but those trees are pollarded

Personal testimony on the Ancestry website has Mark discovering that instead of being 100% British, as he had always believed, he is only 40% British, 25% German and 35% Greek. Mark: its cool that you discovered you may have ancestry from Greece and Germany, though these results dont and probably cant tell you who those people were or how closely you are related to them. But regardless, you remain British, because thats how citizenship works.

The maths of ancestry is a bit bewildering, but there are two steadying anchors. The first is that everyone has two parents. This means that the number of ancestors you have doubles every generation into the past. The second is that there are more people alive today than at any point in history. These two things may seem at odds: the number of ancestors you have goes up as we go back in time, but the number of people alive goes up as we go forward in time. The answer to this apparent conundrum is that we are all inbred.

Sooner or later the number of positions on our family tree are filled with the same people over and over, until at some point all the branches coalesce. Everybody now is descended from everybody then. For Europe, that time is about a thousand years ago. All people of long-standing European descent have the same ancestors a thousand years ago. Whats more, due to the way DNA is chopped up during the creation of sperm and egg cells, we lose genetic information from our actual ancestors, meaning that you have no DNA in common with half of your blood relatives from only three centuries ago.

Scientists are not in the business of telling you how to spend your hard-earned cash, but if you want to find out you have Irish, Scottish or even Viking ancestors, look in the mirror. If you want to find out you have royalty in your family tree, as I show in my book A Brief History of Everyone Who Ever Lived, you do. If you think these things matter, or reveal hidden secrets about your identity, there I cannot help. Family trees may be the ties that bind us, but those trees are pollarded. Most of your ancestry is lost and can never be recovered, not with historical certificates or DNA, despite its many explanatory powers. You, me, Ant and/or Dec we are all descended from multitudes.

Adam Rutherford is a geneticist and author

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Ant and Decs DNA test merely tells us that were all inbred - The Guardian

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Dog DNA Tests: How to discover what your dogs true breed is? – WCBD News 2

Posted: at 1:44 pm

CHARLESTON, S.C. (WCBD) German Shepherd, Poodle, Doberman are common dog breeds that many of us can identify by simply looking at a dog.

However, identifying a dogs breed may not be as easy as we think.

Some studies in the past have indicated that we arent very good at knowing what breeds make a dog up by just looking at them. We have no better chance of guessing than flipping a coin.

Dr. Lucy Fuller, a veterinarian at Charleston Animal Society, explains that dog DNA tests can give a deeper look into all of the breeds that make up a dog.

There are various different types of dog DNA kits but the process is similar in most of them and the process is pretty simple.

Chelsea Rene used a DNA test on three of her dogs that came from three different backgrounds and sent us the results.

See her results below:

You take a swab that comes with the kit and then swab your dogs cheeks to get some cells. Once you get the cells, you send the swab to a lab where they can collect the cells and break them apart then sequence the genome, which will lead to the results.

The dog DNA tests can be used for more than just discovering a dogs breed, it can also help keep them healthy.

Some of these kits allow you to look for certain gene deficienciestheres one called the MDR1 Gene that certain breeds of dogs lack and when you lack that gene, you cant process certain types of drugs properly, so you have to be careful of what drugs you give

The Charleston Animal Society used a dog DNA test on a dog that got a lot of attention a few years ago.

Caitlyn was the dog that was found with her mouth muzzle taped shut in May 2015.

She got so much attention that Charleston Animal Society decided to get a DNA test on her and the results can be seen below:

Cynthia Ohn adopted her dog, Addison, from Charleston Animal Society and received the results of a DNA test that was done by Addisons previous owner.

Although, Ohn said that she probably wouldnt have thought about doing the DNA test herself, it was fun to see the results.

Addisons results can be seen below:

My dog looks like a Yellow Lab and Shar-Pei mix, but it turns out that hes pretty much every dog species known to man.

There are some people who end up being surprised by the results of their dogs test but the surprising result may come down to simple dog genetics.

Dogs can mix genes even more than people can within a litterIts possible for them to have more than one father for a litterso you might get, even amongst a litter of dogs, you might get more genetic diversity than you would in twins.

Although results may not be 100% accurate, dog DNA kits can be a fun way to see what exactly your dog is made of.

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Dog DNA Tests: How to discover what your dogs true breed is? - WCBD News 2

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