Daily Archives: August 20, 2017

Scientists at Duke University say they have combined a cancer immunotherapeutic with nanotechnology to improve the efficacy of both therapies in a mouse study. They published their work, "Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) for the Treatment of Unresectable and Metastatic Cancers," in Scientific Reports.

The new approach also attacked satellite tumors and distant cancerous cells, leading to two mice being cured of the disease and one being vaccinated against it.

Using a combination of immune-checkpoint inhibition and plasmonic gold nanostar (GNS)-mediated photothermal therapy, we were able to achieve complete eradication of primary treated tumors and distant untreated tumors in some mice implanted with the MB49 bladder cancer cells, wrote the investigators. Delayed rechallenge with MB49 cancer cells injection in mice that appeared cured by SYMPHONY did not lead to new tumor formation after 60 days observation, indicating that SYMPHONY treatment induced effective long-lasting immunity against MB49 cancer cells.

"The ideal cancer treatment is noninvasive, safe, and uses multiple approaches," said Tuan Vo-Dinh, Ph.D., the R. Eugene and Susie E. Goodson Professor of Biomedical Engineering, professor of chemistry, and director of the Fitzpatrick Institute for Photonics at Duke University. "We also aim at activating the patient's own immune system to eradicate residual metastatic tumors. If we can create a long-term anticancer immunity, then we'd truly have a cure."

The specific photothermal immunotherapy was developed by Duke researchers and uses lasers and gold nanostars to heat and kill tumors in combination with an immunotherapeutic drug. The technique works based on the ability of nanoparticles to accumulate preferentially within a tumor due to its leaky vasculature, according to the scientists, who add that gold nanostars have the advantage of geometry. With many sharp spikes, they can capture the laser's energy more efficiently, thus permitting them to work with less exposure, making them more effective deeper within a tissue.

"The nanostar spikes work like lightning rods, concentrating the electromagnetic energy at their tips," said Dr. Vo-Dinh. "We've experimented with these gold nanostars to treat tumors before, but we wanted to know if we could also treat tumors we didn't even know were there or tumors that have spread throughout the body."

Dr. Vo-Dinh explained that the body's immune system protects against the growth of cancerous cells. Many tumors, however, overproduce the programmed death-ligand 1 (PD-L1) molecule, which disables T cells so they cannot attack the tumor. A number of drugs are being developed to block the action of PD-L1.

In the study, the Duke team injected bladder cancer cells into both hind legs of a group of mice. After waiting for the tumors to grow, the researchers explored a number of therapies, but only on one of the legs.

Those that received no treatments all quickly succumbed to the cancer, as did those receiving only the gold nanostar phototherapy, because the treatment did nothing to affect the tumor in the untreated leg. While a few mice responded well to the immunotherapy alone, with the drug stalling both tumors, none survived more than 49 days.

The group treated with both the anti-PD-L1 immunotherapy and the gold nanostar phototherapy fared much better, with two of the five mice surviving more than 55 days.

"When a tumor dies, it releases particles that trigger the immune system to attack the remnants," said Dr. Vo-Dinh. "By destroying the primary tumor, we activated the immune system against the remaining cancerous cells, and the immunotherapy prevented them from hiding."

According to Dr. Vo-Dinh, one mouse is still alive almost a year out with zero recurrence of the cancer. When more cancerous cells were injected, the mouse's immune system attacked and destroyed them, demonstrating a vaccine effect in the cured mouse.

The Duke team has plans to follow up with larger cohorts of mice and to work with other clinical researchers to test the treatment on mouse models of brain, breast, and lung cancers.

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Immunotherapy, Nanotech Combine to Kill Cancer Cells More ... - Genetic Engineering & Biotechnology News

Nanotech Security Corp (NTS.V) has ended the week in the red, yielding negativeresults for the shares at they ticked -0.72%.In taking a look at recent performance, we can see that shares have moved 8.66% over the past 4-weeks, 16.95% over the past half year and 26.61% over the past full year.

Traders are keeping a keen eye on shares of Nanotech Security Corp (NTS.V). The Average Directional Index or ADX may prove to be an important tool for trading and investing. The ADX is a technical indicator developed by J. Welles Wilder used to determine the strength of a trend. The ADX is often used along with the Plus Directional Indicator (+DI) and Minus Directional Indicator (-DI) to identify the direction of the trend. Presently, the 14-day ADX is resting at 25.53. Generally speaking, an ADX value from 0-25 would indicate an absent or weak trend. A value of 25-50 would indicate a strong trend. A value of 50-75 would signal a very strong trend, and a value of 75-100 would indicate an extremely strong trend.

Some investors may find the Williams Percent Range or Williams %R as a helpful technical indicator. Presently, Nanotech Security Corp (NTS.V)s Williams Percent Range or 14 day Williams %R is resting at -42.11. Values can range from 0 to -100. A reading between -80 to -100 may be typically viewed as strong oversold territory. A value between 0 to -20 would represent a strong overbought condition. As a momentum indicator, the Williams R% may be used with other technicals to help define a specific trend.

When performing stock analysis, investors and traders may opt to view technical levels. Nanotech Security Corp (NTS.V) presently has a 14-day Commodity Channel Index (CCI) of 37.88. Investors and traders may use this indicator to help spot price reversals, price extremes, and the strength of a trend. Many investors will use the CCI in conjunction with other indicators when evaluating a trade. The CCI may be used to spot if a stock is entering overbought (+100) and oversold (-100) territory.

Checking in on moving averages, the 200-day is at 1.31, the 50-day is 1.30, and the 7-day is sitting at 1.37. Moving averages may be used by investors and traders to shed some light on trading patterns for a specific stock. Moving averages can be used to help smooth information in order to provide a clearer picture of what is going on with the stock. Technical stock analysts may use a combination of different time periods in order to figure out the history of the equity and where it may be headed in the future. MAs can be calculated for any time period, but two very popular time frames are the 50-day and 200-day moving averages.

Shifting gears to the Relative Strength Index, the 14-day RSI is currently sitting at 57.53, the 7-day is 56.83, and the 3-day is currently at 53.78 for Nanotech Security Corp (NTS.V). The Relative Strength Index (RSI) is a highly popular momentum indicator used for technical analysis. The RSI can help display whether the bulls or the bears are currently strongest in the market. The RSI may be used to help spot points of reversals more accurately. The RSI was developed by J. Welles Wilder. As a general rule, an RSI reading over 70 would signal overbought conditions. A reading under 30 would indicate oversold conditions. As always, the values may need to be adjusted based on the specific stock and market. RSI can also be a valuable tool for trying to spot larger market turns.

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Share Performance Update on Nanotech Security Corp (NTS.V) - Morgan Research

DUBLIN, August 17, 2017 /PRNewswire/ --

The "Global Nanotech-enabled Aircraft Power Solutions Market 2017-2021" report has been added to Research and Markets' offering.

The global nanotech-enabled aircraft power solutions market to grow at a CAGR of 8.89% during the period 2017-2021.

The report, Global Nanotech-Enabled Aircraft Power Solutions Market 2017-2021, has been prepared based on an in-depth market analysis with inputs from industry experts. The report covers the market landscape and its growth prospects over the coming years. The report also includes a discussion of the key vendors operating in this market.

The latest trend gaining momentum in the market is the emergence of zero-fuel aircraft. Zero-fuel aircraft use photovoltaic panels that absorb energy from the sun and convert them into energy to thrust the engines. Of late, there has been an increasing interest in the commercial and civil sectors for using such aircraft in applications, including agriculture, aerial photography, 3D mapping, wildlife protection, and provision of internet access in remote places. With the growing need for reduction of greenhouse gases emissions, government agencies, in collaboration with private entities, are significantly developing new approaches, such as the use of solar technologies and maximizing the absorption of solar power.

According to the report, one of the major drivers for this market is demand for lightweight and fuel-efficient aircraft. To address the challenges arising from global warming and climatic changes, aerospace stakeholders are actively promoting carbon-reducing measures and energy savings. These initiatives are expected to bring down greenhouse gas emissions that have adverse environmental impacts. Since the late 90s, a number of initiatives have been directed toward substantially reducing the fuel consumptions during flight, landing, and taxiing of aircraft.

Further, the report states that one of the major factors hindering the growth of this market is constrained durability and instability of nanoparticles. The robustness of fuel cell systems is lower compared with the internal combustion engines, particularly in the specific temperature and humidity ranges in which an aircraft driven by a fuel cell would operate. The durability of a commonplace fuel cell stack is half the optimum durability required for its use in commercial aviation.

Key vendors

Other prominent vendors

Key Topics Covered:

Part 01: Executive Summary

Part 02: Scope Of The Report

Part 03: Research Methodology

Part 04: Introduction

Part 05: Market Landscape

Part 06: Market Segmentation By Application

Part 07: Geographical Segmentation

Part 08: Decision Framework

Part 09: Drivers And Challenges

Part 10: Market Trends

Part 11: Vendor Landscape

Part 12: Appendix

For more information about this report visit https://www.researchandmarkets.com/research/n63cgn/global

Media Contact:

Laura Wood, Senior Manager rel="nofollow">press@researchandmarkets.com

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SOURCE Research and Markets

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Global Nanotech-enabled Aircraft Power Solutions Market to Grow ... - Markets Insider