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Monthly Archives: July 2017
Scientists regenerate retinal cells in mice – Medical Xpress
Posted: July 26, 2017 at 3:46 pm
July 26, 2017 A microscope image showing glia cells and neurons in the eye's retina. Credit: Tom Reh lab/UW Medicine
Scientists have successfully regenerated cells in the retina of adult mice at the University of Washington School of Medicine in Seattle.
Their results raise the hope that someday it may be possible to repair retinas damaged by trauma, glaucoma and other eye diseases. Their efforts are part of the UW Medicine Institute for Stem Cell and Regenerative Medicine.
Many tissues of our bodies, such as our skin, can heal because they contain stem cells that can divide and differentiate into the type of cells needed to repair damaged tissue. The cells of our retinas, however, lack this ability to regenerate. As a consequence, injury to the retina often leads to permanent vision loss.
This is not the case, however, in zebrafish, which have a remarkable ability to regenerate damaged tissue, including neural tissue like the retina. This is possible because the zebrafish retina contains cells called Mller glia that harbor a gene that allows them to regenerate. When these cells sense that the retina has been injured, they turn on this gene, called Ascl1.
The gene codes for a type of protein called a transcription factor. It can affect the activity of many other genes and, therefore, have a major effect on cell function. In the case of the zebrafish, activation of Ascl1 essentially reprograms the glia into stem cells that can change to become all the cell types needed to repair the retina and restore sight.
The team of researchers in the new study were led by Tom Reh, University of Washington School of Medicine professor of biological structure. The scientists wanted see whether it was possible to use this gene to reprogram Mller glia in adult mice. The researchers hoped to prompt a regeneration that doesn't happen naturally in mammal's retina.
Their research findings appear online July 26 in the journal Nature. The lead author is Nikolas Jorstad, a doctoral student in the Molecular Medicine and Mechanisms of Disease program at the University of Washington.
Like humans, mice cannot repair their retinas. Jorstad said that to conduct their experiment, the team "took a page from the zebrafish playbook." They created a mouse that had a version of the Ascl1 gene in its Mller glia. The gene was then turned on with an injection of the drug tamoxifen.
Earlier studies by the team had shown that when they activated the gene, the Mller glia would differentiated into retinal cells known as interneurons after an injury to the retina of these mice. These cells play a vital role in sight. They receive and process signals from the retina's light-detecting cells, the rods and the cones, and transmit them to another set of cells that, in turn, transfer the information to the brain.
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In their earlier research, however, the researchers found that activating the gene worked only during the first two weeks after birth. Any later, and the mice could no longer repair their retinas. Reh said that at first they thought another transcription factor was involved. Eventually they determined that genes critical to the Mller glia regeneration were being blocked by molecules that bind to chromosomes. This is one way cells "lock up" genes to keep them from being activated. It is a form of epigenetic regulationthe control of how and when parts of the genome operate.
In their new paper, Reh and his colleagues show that, by using a drug that blocks epigenetic regulation called a histone deacetylase inhibitor, activation of Ascl1 allows the Mller glia in adult mice to differentiate into functioning interneurons. The researchers demonstrated that these new interneurons integrate into the existing retina, establish connections with other retinal cells, and react normally to signals from the light-detecting retinal cells.
Reh said his team hopes to find out if there are other factors that can be activated to allow the Mller glia to regenerate into all the different cell types of the retina. If so, it might be possible, he said, to develop treatments that can repair retinal damage, which is responsible for several common causes of vision loss.
Explore further: Study helps explain how zebrafish recover from blinding injuries
More information: Nikolas L. Jorstad et al, Stimulation of functional neuronal regeneration from Mller glia in adult mice, Nature (2017). DOI: 10.1038/nature23283
Journal reference: Nature
Provided by: University of Washington
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Gene therapy to correct surfactant protein B deficiency in newborns – Medical Xpress
Posted: at 3:46 pm
July 26, 2017
An article published in Experimental Biology and Medicine (Volume 242, Issue 13, July, 2017) reports that gene therapy may be used to as an intermediate therapy for newborns with surfactant protein deficiencies until lung transplantation becomes an option. The study, led by Dr. David Dean in the Division of Neonatology at the University of Rochester in Rochester NY reports that electroporation-mediated delivery of the surfactant B gene to deficient mice improves lung function and survival.
Surfactant is present in the lungs of all humans. This important protein makes it easier for people to breath. Without it, lungs would collapse with each breath. Surfactant protein B (SPB) deficiency is a rare but fatal disease that affects full term babies after an apparently uncomplicated pregnancy and delivery. Babies with SBP deficiency have severe breathing problems from birth, and die in infancy even with aggressive medical treatment. To date the only effective treatment is a lung transplant. Given how quickly these babies become ill, and the limited number of available organs, transplantation is often not even an option.
The most promising therapy for this devastating disease is replacement of the absent SPB gene, a process called gene therapy. Gene therapy approaches using viral-based delivery techniques have not achieved therapeutic levels of SPB protein and induce inflammation, which can exacerbate the disease. The current study used electroporation-based delivery techniques which result in higher levels of transgene expression and are well-tolerated even in animals with existing lung injury. Delivery of SPB DNA into the lung cells of SPB-deficient mice reduced lung inflammation, improved lung function, and extended survival. Since the DNA is eventually silenced, SPB expression does not last forever and this is approach cannot provide a cure.
Dr. Barnett, a neonatology fellow and coauthor said "although this treatment does not provide lifelong correction, our data suggest that this may be a useful approach for improving the survival and stability of infants until lung transplant can occur." Dr. Dean added "we are excited to help optimize an approach that may treat and someday even cure this and other devastating diseases."
Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine, said, "Dean and colleagues provide evidence that gene therapy may restore surfactant activity in SPB deficiency for sufficient time to allow lung transplants in a greater number of affected neonates. This is represents an important advance in this field of research."
Explore further: Gene delivery to the lung can treat broad range of diseases within and beyond the lung
Data demonstrating sustained protein expression five years after a single intramuscular injection of a gene-based therapy for the treatment of alpha-1 antitrypsin (AAT) deficiency also shows improvements in multiple indicators ...
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Phase 2/3 Trial of Elamipretide to Treat Barth Syndrome Now Enrolling Patients – Mitochondrial Disease News
Posted: at 3:46 pm
A Phase 2/3 clinical trial of elamipretide,a potential treatment for a rare mitochondrial disease known asBarth syndrome, is now enrolling patients, the therapys developer,Stealth BioTherapeutics, announced.
The TAZPOWER study (NCT03098797) will be conducted in McKusick-Nathans Institute of Genetic Medicine, at the Johns Hopkins University School of Medicine, and is expected to include 12 patients, ages 12 or older, with genetically confirmed Barth syndrome and stable symptoms, butimpaired walking ability.
Our understanding of Barth syndrome and how it manifests has evolved significantly, but current treatment efforts are still limited to the management of symptoms, Hilary Vernon, anassistant professor of pediatrics at the McKusick-Nathans Institute and the studys primary investigator, said in a press release. The initiation of TAZPOWER represents an important milestone in the potential development of a disease-specific treatment option.
Barth syndrome is a rare inherited mitochondrial disease that is almost exclusive to males. This disease is characterized by cardiac abnormalities, skeletal muscle weakness, recurrent infections due to low white blood cell (immune cell) counts, and delayed growth. It is caused by caused by genetic mutations in the TAZ gene, which encodes the protein tafazzin that is essential for the normal functioning of mitochondria.
The severe problems experienced by patients with Barth syndrome are caused by misshapen and dysfunctional mitochondria, which reduce the energy production in the affected tissues. The resulting muscle weakness can lead to severe fatigue, heart failure and death, said Doug Weaver, chief medical officer at Stealth. In this study, we hope to show that elamipretide may have clinical benefit by improving function in these affected mitochondria.
Elamipretidewas designed to restore mitochondrias ability to work as the cells power source. Due to its capacity to penetrate the inner membrane of mitochondria, the therapy as the potential to reduce the levels of damaging oxidative stress produced by mitochondrias dysfunctional activity.
TAZPOWER trial is a placebo-controlled crossover study, designed to evaluate the effects of daily administration of elamipretide in patients with Barth syndrome. All participants will receive single daily subcutaneous injections of elamipretide or placebo for 12 weeks, followed by a four-week wash-out period. This will then be followed by additional 12 weeks of therapy, but this time the patients will switch the treatment received, with those previously givenelamipretide now receivinga placebo and vice-versa.
The drugs efficacy will be measured by changes in the distance that patients are able to walk during the 6-minute walk test (6MWT). Secondary endpoints will include other functional assessments (of muscle strength, balance, etc.), patient-reported outcomes, and overall treatment safety.
This study underscores our commitment to develop elamipretide for the treatment of rare genetic mitochondrial diseases, said Reenie McCarthy, Stealths chief executive officer.
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Phase 2/3 Trial of Elamipretide to Treat Barth Syndrome Now Enrolling Patients - Mitochondrial Disease News
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Why immigrants are the best thing to happen to Michigan – Detroit Metro Times
Posted: at 3:45 pm
The other night, I was watching Mel Brooks' hilariously funny Blazing Saddles, possibly the most politically incorrect movie ever made. The n-word is used more often in the opening scenes than Donald Trump says "trust me" in a week.
Yet somehow, it isn't really offensive, because the movie is poking fun at us and our weaknesses as a society.
Every sexist and racist stereotype is gleefully invoked, parodied and thereby, effectively demolished.
When it was over, I suddenly realized something: Sadly, that movie could never be made today. Not because we are more enlightened, but because we no longer are self-confident enough as a people and a nation to laugh at ourselves.
Not that everything was peachy when Blazing Saddles was being made. The film was released when the country was neck-deep in the Watergate scandal. Inflation was rising. America's participation in the Vietnam War had ended just a year earlier, and we all knew it was a horrible failure.
Yet we still believed in the idea of America, that this was the best nation in the world. The next year, when the tottering corpse of South Vietnam finally collapsed, we took in thousands of refugees. We knew immigrants had made this nation great.
Not anymore.
Flash forward four decades, to a nation whose president won his office in large part by stirring up everything in the dark recesses of the American soul. That meant, first of all, attacking immigrants and blaming them for society's ills.
Donald Trump ran the nastiest anti-immigrant campaign this nation has seen since the Know Nothing movement back before the Civil War. He managed to make millions feel that Muslims were terrorists and Mexicans drug dealers and rapists.
What's more, he made people feel that immigrants, legal as well as illegal, were taking their jobs, and vowed to crack down on immigration and get Americans their jobs back.
Enough people in the right places believed him to put him in the White House. Yes, we will be sorting out and dealing with the ramifications of that for the rest of our lives.
We can, as a result, only hope that the babies being born this year will someday live in a United States of America with a government they can be proud of.
But that's not the topic today. Immigration is.
What I fear is that people will still believe Trump's lies about immigrants and immigration even after he is discredited and disgraced, is hauled out of office, is defeated, dies, or decides to leave of his own accord. So now, here's the truth:
Immigrants are right now perhaps more than ever the best thing to happen to Michigan.
They create more jobs than native-born Americans. They improve communities, start businesses, and invent things needed to make us economically competitive again.
That's been clear to everyone who worked with immigrant communities for a long time. But now, we have documented proof of that. Earlier this month, the Michigan Economic Center, a non-profit based in Ann Arbor, released a carefully researched study on immigration's impact on this state.
The study, "Michigan: We Are All Migrants Here," conclusively shows that we would be in a lot worse shape without the immigration we've had in recent years.
John Austin, who was until January president of the State Board of Education, founded the center and is a main author of the study. "Michigan relies on legal immigrants to grow our economy, and we literally cannot afford policies that discourage them from coming, or that chase away those who are here," he says.
The study, which Austin did in collaboration with former State Rep. Steve Tobocman's group Global Detroit, effectively exposes many myths about immigrants as blatant lies.
Far from being a drain on Michigan, immigrants are essential to its economy. Detroit hasn't stopped losing people in the last few years, but the outflow has slowed dramatically.
This is, however, almost entirely due to immigrants. Detroit's immigrant population grew by 13 percent between 2010 and 2014; the native-born kept heading for the exits.
Statewide, the picture was much the same; Michigan's foreign-born population has grown nearly 25 percent since 2002 which more than accounts for what growth there's been.
That doesn't mean they are taking over. Far from it; Michigan has the smallest percentage of its population born outside this country of any state except Louisiana.
That's only 650,000 people, or just over six percent. But as Austin likes to say, economically they "punch above their weight." About 31,000 are self-emplyed, and they employ some 150,000 people.
Immigrants are, the study says, responsible for nearly all the net new growth in mid-sized, "Main Street" businesses.
They aren't just running hotels and hiring counter help; they are creating the economy of the future. Immigrants are behind 25 percent of the state's high-tech startups.
They are the owners or co-owners of more than three-quarters of the patents issued to the state's top research universities. They are, on average, better educated than the native-born, especially in STEM (Science, Technology, Engineering, and Math) areas and jobs.
They are, in short, Detroit and Michigan's economic future if we are to have one. Gov. Rick Snyder can be a bumbler, but he understood that much; to his credit, he tried (unsuccessfully) in 2014 to get Washington to give Michigan 50,000 extra visas for skilled or highly educated immigrants.
To be sure, some immigrants aren't well-educated; one of the curious findings of the study was that while immigrants on average have more education than the native born, a higher percentage of them have less than a high school degree.
But the study notes that "research strongly indicates ... that far from being an economic drain, these immigrants are important to many Michigan industries," because they are willing to do the jobs those born here are seldom willing to do.
Few Michigan immigrants are undocumented, aka "illegal." But that doesn't mean Trump's persecutions don't have an effect. Austin told me that after dozens of Chaldeans were rounded up and arrested in the Detroit suburbs last month, that "sent a chilling message to Michigan's legal immigrants, current and future: You are not welcome here."
Trump's anti-immigrant policies are, in fact, more damaging to Michigan than most places. What the Michigan Economic Center study recommends is that the politicians collaborate with business leaders to make this the most welcoming state in the nation.
Otherwise, we may get to see immigrants fleeing or shunning our state and what prosperity we have with them.
What about terrorism?
Those wanting to severely limit immigration, especially from the Middle East, often parrot fears about Islamic terrorism. This, to be sure, deserves consideration, but the government has been doing rigorous screening since 9/11, long before Trump arrived.
Except for that event, virtually all of those committing terrorist acts in this country have been Americans born here.
Some have been Muslim, or pretended to be, but the worst domestic terrorist attack by far, apart from 9/11, was the Oklahoma City bombing, carried off by those two good old Christian boys, Timothy McVeigh and the mauler from Michigan's thumb, Terry Nichols.
And whether Trump fears assassination isn't known, but he might be interested to know that most of our famous assassins or would-be assassins Lee Harvey Oswald, Arthur Bremer, Mark David Chapman, Sirhan Sirhan, John Hinckley were young, white, and mostly Christian men.
What about leaving the job-creating immigrants alone, and deporting all the native-born white male 20-somethings instead? Frankly, that might make more sense.
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Time to punish bad behavior – St. Louis Jewish Light
Posted: at 3:45 pm
O.J. is free again.
As a society we seem to tolerate and even encourage bad behavior. Our major institutions, such as public schools and government, do not do a very effective job of using rewards to incentivize good behavior and punishments to dis-incentivize bad behavior.
We can debate the relative merits of using rewards and punishments as tools to influence conduct, whether in parenting, the justice system, or other areas of human endeavor. Rewards today are handed out indiscriminately, while punishments tend to be scarce.
To the extent that carrots and sticks are employed as behavior modification techniques, the former are much more in vogue than the latter, as positive reinforcement is viewed as far superior to negative sanctions. From Dr. Spock disciples to character education gurus to penologists, experts on human behavior seem punishment-averse.
The no-spanking philosophy of child-rearing has morphed into a no-consequences culture generally. There is the self-esteem driven trophy syndrome in school and little league sports that rewards the slightest accomplishment. The reluctance to penalize poor performance extends now to college, where the customer is always right, everyone is a critical thinker and coddling paradigms combine to produce ever-increasing grade inflation.
The ultimate example of our punishment-averse mindset is the growing deincarceration call to release inmates from prisons on the twin assumption that sentences are too harsh and jails only produce more hardened criminals. The once ballyhooed broken windows theory of policing, which prescribed zero tolerance for accepting even the most minor infractions, has gone out the window, a victim of the post-Ferguson demonization of law enforcement. Where once we tried to internalize the norm that it is wrong to jump subway turnstiles, the new norm is it is wrong to lock up folks who steal and reveal 750,000 classified, highly sensitive national security documents.
Is it possible we are devaluing punishment as a way to help shape behavior that benefits both the individual and society? We constantly hear about research claiming punishment does not work. Yet, speaking for myself, when I was driving on Highway 40 recently and saw a sign warning Hit A Worker Pay $10,000 Fine and Lose License, it got me to slow down. I doubt I was the only motorist so impacted.
It got me to thinking, why dont we put up signs on the roadway warning Get your high school diploma, then get a job, then get married, and only then have kids, or else you have a high probability of ending up poor? Even more incentivizing, how about a sign that says Put marriage before the baby carriage, and you will have an 86 percent chance of having an income in the middle or top third of all incomes?
These data are based on numerous empirical studies done by both liberal and conservative research organizations, such as the Brookings Institution and the American Enterprise Institute, which conclude that, if one were to follow a relatively simple sequence of behaviors, poverty could be virtually eliminated. (See George Will, Listen Up, Millennials, Theres Sequence to Success, Washington Post, July 5.)
But instead of sending a message to young people that bad life choices have consequences, our leading institutions excuse such behavior as rooted in poverty and addressable through massive welfare programs.
This is not rocket science. It is common sense, backed by science. The same folks on the left who criticize Donald Trump as (being morally flawed and anti-scientific) are in no position to throw stones themselves. They have contributed to the collapse of the norms Will and others celebrate, as liberal media such as The New York Times are at best nonjudgmental about marriage and having kids out of wedlock and at worst question and thus undermine the institution of matrimony and family values. And they ignore the substantial science behind the sequencing hypothesis.
We have no problem growing the nanny state when it comes to education campaigns and laws relating to climate change, seat belt safety, labeling of cigarette packages, anti-bullying, multicultural competency, and other such issues. Is it too politically incorrect to hammer away, also, at the themes suggested above, at a time when the Pew Research Center reports the share of Americans who are married is at its lowest point since at least 1920 and the out-of-wedlock birthrate is roughly 50 percent?
The larger matter here is that social justice and compassion, which are wonderful aspects of Judaism, must be joined with some sense of personal responsibility, which has been lost along the way. Granted, some people have more choices than others. Nonetheless, we all have choices.
A good place to start is in the schools. There is a big movement in schools today to teach the whole child, that is, to cater to not just the academic but also social-emotional needs of students. Grit is the latest educationist buzzword, referring to developing ones capacity for self-control, delayed gratification, persistence, and resilience. However, it is not clear how such qualities can be cultivated in a no-consequences environment.
Many schools no longer allow students to get a failing grade, which means students rarely have to test their coping mechanisms. As a result, on those occasions when they are faced with adversity, they get stressed easily and can experience serious mental health problems, a growing reality widely reported by school counselors at every level.
Of course, poverty, mental illness, crime, and other problems are complicated and defy simple solutions. One modest proposal is that, from the cradle to the grave, we give a little more love to the first half of the tough-love equation. Each of us and the society as a whole will be the better for it.
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Time to punish bad behavior - St. Louis Jewish Light
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Professor Criticizes Beijing Censorship At University of Montana’s ‘Confucius Institute’ – Newstalkkgvo
Posted: at 3:45 pm
Photo courtesy of Jon King
History Professor Steven Levine is a specialist in East Asian affairs at the University of Montana. Fluent In Chinese, Levine was partly responsible for bringing the Confucius Institute to the state, a decision he now says was a mistake that has opened the door to Beijing soft power.
When I was at the Mansfield Center as Associate Director, I was partly responsible for bringing the Confucius Institute to the University of Montana, and, frankly, now I regret it because the Confucius institute, which is not particularly active actually at UM, is in fact an instrument of Chinese soft power.
Levine says the Confucius Institute offered money and language opportunities to the cash-strapped university, but he has come to be very critical of the educational structure of the institute.
The teachers are very carefully vetted to make sure that they dont differ one syllable from any of the official lines in Beijing, Levine said. As you get beyond the basic ABCs, so to speak, of Chinese, the books that are used and the teachers that are teaching them are forbidden by their contract from speaking about things like Tibet, for example, or Taiwan, or Liu Xiaobo, the Noble Prize winner that just died. They are constrained and censored basically.
Levine says it is unfortunate that Montanas education system cannot supply language teachers and funds to teach one of the worlds most important languages, rather than rely on Beijing.
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Professor Criticizes Beijing Censorship At University of Montana's 'Confucius Institute' - Newstalkkgvo
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This 31-year-old Ron Paul Republican is now the mayor of Ocean Springs, Mississippi – Rare.us
Posted: at 3:44 pm
By Andrew Marc Di Giovanna
In June, 31-year-old Shea Dobson unseated Democrat Connie Moran from her position as mayor of Ocean Springs, Mississippi. Though Moran was a three-term incumbent facing an opponent with no previous experience holding political office, Dobson won a decisive, double-digit victory, garnering 55 percent of votes to Morans 45 percent.
Dobsons story begins in 2008. While visiting his father in Tennessee, Dobson watched a presidential debate featuring former Congressman Ron Paul (R-Tex.), who immediately caught his attention. Feeling inspired, Dobson started closely following Congressman Paul and set out on a roadtrip to participate in the Revolution March on July 12 of that year. That was really when I [realized] its not just a couple friendly people, theres really something here, Mayor Dobson commented.
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Then, in 2012, Dobson began canvassing and knocking on doors for Congressman Pauls second presidential campaign. With the help of his fellow liberty-leaning conservatives, their team took over our entire county republican party and sent a 100 percent pro-Ron Paul slate of delegates to the state convention, Dobson boasted.
That was only the beginning of Dobsons involvement in the liberty movement. In 2013, he founded a Young Americans for Liberty (YAL) chapter at the University of Southern Mississippi and was quickly promoted to Mississippi State Chair with the organization. After graduating, he moved on to work for the National Association for Gun Rights (NAGR), Concerned American Voters, Students for Liberty (SFL) and Americans for Prosperity (AFP), in addition to canvassing for Senator Rand Pauls 2016 presidential campaign and later volunteering for Gary Johnsons independent run. Dobsons extensive involvement in grassroots activism and various leadership roles provided him with the experience and vision necessary to take on his next big move a bid for the mayoral seat in Ocean Springs.
Throughout the mayoral race, Moran repeatedly criticized Dobson for his youth and inexperience, which he fiercely combated. Ive been on the ground working with people, Dobson said. Thomas Jefferson signed the Declaration of Independence when he was 32. Dont tell me that young men cant do great things.
Instead, Dobson used his youth to reach the voters of Ocean Springs. Having previously been a passive observer in the political scene, Dobson is familiar with the attitudes many voters have about discussing politics. You [have to] talk to people about their average, everyday lives, Dobson explained. Taking a more grassroots approach, Dobsons volunteers were composed of local residents and friends of his. By having more of a politically secular base, Dobson was able to keep his message intact and reach constituents in ways his opponent could not.
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A post shared by Shea Dobson (@sheadobson) on Jun 21, 2017 at 3:47pm PDT
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After taking office on June 30th, 2017, Mayor Dobson is off to a solid start but there are certainly challenges, such as excessive city-level regulations, that he intends to address. He is confident in the character and good-heartedness of Ocean Springs residents to work together in addressing the needs of their community. His election represents the spirit of the American people who are simply fed up with establishment, salesman type politicians, willing instead to elect a man with passion and principle. Dobson intends to Get people working towards a common cause for the betterment of his community.
When asked what advice he has for liberty activists seeking to run for office, Dobson said, Theres no perfect time to take on a project. Dont be afraid of how big the mountain is to climb. Surround yourself with good people [who ]are [willing] to work hard and do everything they can to help you out. Keep your head down when it comes to a lot of the political chatter. Work hard, and tell the truth.Dobson will be at the YAL National Convention in Reston, VA this week to speak with and guide 400 liberty youth activists.
Andrew Di Giovanna serves as California State Chair with Young Americans for Liberty, where he empowers activists at the local level. Andrew currently studies Biology at Citrus College with an aim to practice orthodontics.
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This 31-year-old Ron Paul Republican is now the mayor of Ocean Springs, Mississippi - Rare.us
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What the Gay Lobby Doesn’t Want You to Know – Church Militant – Church Militant
Posted: at 3:41 pm
A decade ago, personal video testimonials of people "coming out" as gay exploded on YouTube. Now, search the term "ex-gay," and you'll find an explosion of testimonials from those who've left the homosexual lifestyle and have never looked back.
But this is the news the LGBT lobby doesn't want anyone to know, because it bursts the myth that people are "born that way" and they can never really change. So invested are they in the narrative that they've lobbied states to outlaw reparative therapy voluntary counseling that helps diminish or eliminate unwanted same-sex attraction. Currently, nine states and counting have banned such therapy for minors, meaning youth who seek help in ridding themselves of homosexual desires can no longer do so with a licensed therapist in those states.
But counselors are hitting back. Remarkably, in a stunning federal filing in May, tens of thousands of licensed therapists and clients lodged a massive fraud claim against the LGBT lobby accusing them of misinformation and outright lies regarding the "born that way" narrative and reparative therapy. And secular media are propping up the fraud, promoting the false notion that reparative therapy resorts to torture, shaming and "shock treatment" none of it true.
The late Dr. Joseph Nicolosi, a pioneer in reparative therapy, helped many men recapture their heterosexual orientation.
"Homosexuality is not about sex," Nicolosi said. "It is about a person's sense of himself, about his relationships, how he forms and establishes relationships, his self-identity, his self-image, personal shame, his ability to sustain intimacy."
"Homosexual behavior is always prompted by an inner sense of emptiness," he explained.
Often, when childhood wounds were healed, men would find their same-sex desires diminish or disappear completely, replaced with a healthy, heterosexual attraction.
"Findings from preliminary data collected over a 12-month period indicated statistically significant reductions in distress and improvements in well-being, significant movement toward heterosexual identity, and significant increases in heterosexual thoughts and desires with accompanying significant decreases in homosexual thoughts and desires," he summarized.
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What the Gay Lobby Doesn't Want You to Know - Church Militant - Church Militant
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Investigator: Driver part of larger human-smuggling scheme – The Denver Post
Posted: at 3:41 pm
SAN ANTONIO Investigators believe a truck driver accused in the deaths of 10 people found inside a packed, sweltering tractor-trailer is part of a larger organization involved in human smuggling that authorities are trying to identify and dismantle, a U.S. immigration official said.
Some of the 29 identified survivors told authorities they hired smugglers who brought them across the U.S. border, loaded them onto trucks that took them to the tractor-trailer, and marked them with different colored tape to identify them to various smugglers who would be picking them up after the tractor-trailer reached its destination.
Were certainly not stopping at looking at the driver. Were trying to investigate and identify the different cogs, the stash houses, the other members, where the money came from, Shane Folden, special agent in charge of U.S. Immigration and Customs Enforcements Homeland Security Investigations office in San Antonio, told The Associated Press on Tuesday.
The driver, James Matthew Bradley Jr., 60, of Clearwater, Florida, is facing charges of illegally transporting immigrants for financial gain, resulting in death. Bradley could face the death penalty if convicted. Authorities allege he drove a trailer full of immigrants from South Texas that was discovered in the parking lot of a Walmart in San Antonio early Sunday morning.
Folden said charging Bradley is just the first step in the case as investigators work to find others involved in the scheme, including those responsible for facilitating money transfers and bringing the immigrants across the border.
The ultimate goal is to dismantle the complete organization. You dont get there by only focusing on one aspect. You have to look at potential targets and potential related locations, both north and south, he said.
U.S. Rep. Henry Cuellar from Texas said he was informed by law enforcement that the tractor-trailer cleared a Border Patrol checkpoint Saturday night, about two hours before it was discovered, roughly 29 miles (47 kilometers) north of the border on Interstate 35 near Laredo. Cuellar said he didnt know whether the immigrants were loaded into the truck before or after it crossed the checkpoint.
U.S. authorities are still trying to determine how many people were inside the tractor-trailer because some fled before police arrived, Folden said.
Thirteen people who rode in the trailer remained hospitalized Tuesday in San Antonio, said ICE spokesman Greg Palmore. He declined to say how many were critical or in life-threatening condition. Officials said at least 29 people survived the smuggling attempt.
Delmin Daro Lpez Colomo, 23, a Guatemalan survivor who remained hospitalized, said the migrants in the tractor-trailer were delivered by various different smugglers, according to Cristy Andrino, the consul of Guatemala in McAllen, Texas.
Adan Lara Vega, 27, a migrant from Mexico who survived the smuggling attempt, told the AP on Monday that they boarded the truck on a Laredo street Saturday night for the two-hour trip to San Antonio. He said the trailer was already full of people, but it was so dark he couldnt tell how many.
At least some of the survivors are likely to become witnesses and receive consideration to remain in the United States to testify, Folden said.
Its likely that most if not all of the survivors will be allowed to stay in the country to help authorities in their investigation, said Jeff Vaden, a former federal prosecutor who helped oversee the prosecution of a 2003 smuggling attempt in Victoria, Texas, in which 19 people died.
Vaden said many of the more than 50 immigrants who survived that attempt were able to identify the people who harbored them or transported them or to whom they paid or spoke. Thats what enabled the government to put together the larger smuggling case above just the driver. Just like in any crime, the victims are critical witnesses. Vaden is now a partner at the Houston law firm of Bracewell LLP.
Jacob Monty, an immigration lawyer in Houston, said the help survivors give to authorities could lead to permanent residency.
Bradley, the driver of the truck found in San Antonio, remained jailed Tuesday. He had his commercial driving privileges for a truck driver suspended by Florida three months before Sundays deadly smuggling attempt, officials said Tuesday.
Court records show Bradley had been repeatedly cited for violating federal motor carrier safety regulations in Iowa dating back to 1995. At least two of the tickets were for logging more hours than allowed.
Federal regulators said they are also conducting an investigation into an Iowa trucking company whose name was on the trailer. Brian Pyle, owner of Pyle Transportation, said the trailer had been sold on May 10 to an individual in Mexico, and Bradley was working as an independent contractor to drive it to Brownsville, Texas, to carry out the sale.
Its unclear what will happen to one of the migrants who died, identified as 19-year-old Frank Guisseppe Fuentes. His parents, who live in Maryland and are in the U.S. illegally, havent yet told Guatemalan officials what they want done with his body. Andrino, the Guatemalan consul, said they may fear agents could come after them if they claim their son.
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Investigator: Driver part of larger human-smuggling scheme - The Denver Post
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Human Ken Doll Rodrigo Alves is ‘waiting for his new chin to arrive in the post’ ahead of 35k surgery binge – The Sun
Posted: at 3:41 pm
The Sun | Human Ken Doll Rodrigo Alves is 'waiting for his new chin to arrive in the post' ahead of 35k surgery binge The Sun THE HUMAN Ken Doll's new chin is in the post - and the Brazilian reality star can't wait to unpack it and get it under his skin. The 34-year-old star - real name Rodrigo Alves - revealed he is waiting for the odd delivery at a hotel in Kish, Iran ... |
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Human Ken Doll Rodrigo Alves is 'waiting for his new chin to arrive in the post' ahead of 35k surgery binge - The Sun
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