The Prometheus League
Breaking News and Updates
- Abolition Of Work
- Ai
- Alt-right
- Alternative Medicine
- Antifa
- Artificial General Intelligence
- Artificial Intelligence
- Artificial Super Intelligence
- Ascension
- Astronomy
- Atheism
- Atheist
- Atlas Shrugged
- Automation
- Ayn Rand
- Bahamas
- Bankruptcy
- Basic Income Guarantee
- Big Tech
- Bitcoin
- Black Lives Matter
- Blackjack
- Boca Chica Texas
- Brexit
- Caribbean
- Casino
- Casino Affiliate
- Cbd Oil
- Censorship
- Cf
- Chess Engines
- Childfree
- Cloning
- Cloud Computing
- Conscious Evolution
- Corona Virus
- Cosmic Heaven
- Covid-19
- Cryonics
- Cryptocurrency
- Cyberpunk
- Darwinism
- Democrat
- Designer Babies
- DNA
- Donald Trump
- Eczema
- Elon Musk
- Entheogens
- Ethical Egoism
- Eugenic Concepts
- Eugenics
- Euthanasia
- Evolution
- Extropian
- Extropianism
- Extropy
- Fake News
- Federalism
- Federalist
- Fifth Amendment
- Fifth Amendment
- Financial Independence
- First Amendment
- Fiscal Freedom
- Food Supplements
- Fourth Amendment
- Fourth Amendment
- Free Speech
- Freedom
- Freedom of Speech
- Futurism
- Futurist
- Gambling
- Gene Medicine
- Genetic Engineering
- Genome
- Germ Warfare
- Golden Rule
- Government Oppression
- Hedonism
- High Seas
- History
- Hubble Telescope
- Human Genetic Engineering
- Human Genetics
- Human Immortality
- Human Longevity
- Illuminati
- Immortality
- Immortality Medicine
- Intentional Communities
- Jacinda Ardern
- Jitsi
- Jordan Peterson
- Las Vegas
- Liberal
- Libertarian
- Libertarianism
- Liberty
- Life Extension
- Macau
- Marie Byrd Land
- Mars
- Mars Colonization
- Mars Colony
- Memetics
- Micronations
- Mind Uploading
- Minerva Reefs
- Modern Satanism
- Moon Colonization
- Nanotech
- National Vanguard
- NATO
- Neo-eugenics
- Neurohacking
- Neurotechnology
- New Utopia
- New Zealand
- Nihilism
- Nootropics
- NSA
- Oceania
- Offshore
- Olympics
- Online Casino
- Online Gambling
- Pantheism
- Personal Empowerment
- Poker
- Political Correctness
- Politically Incorrect
- Polygamy
- Populism
- Post Human
- Post Humanism
- Posthuman
- Posthumanism
- Private Islands
- Progress
- Proud Boys
- Psoriasis
- Psychedelics
- Putin
- Quantum Computing
- Quantum Physics
- Rationalism
- Republican
- Resource Based Economy
- Robotics
- Rockall
- Ron Paul
- Roulette
- Russia
- Sealand
- Seasteading
- Second Amendment
- Second Amendment
- Seychelles
- Singularitarianism
- Singularity
- Socio-economic Collapse
- Space Exploration
- Space Station
- Space Travel
- Spacex
- Sports Betting
- Sportsbook
- Superintelligence
- Survivalism
- Talmud
- Technology
- Teilhard De Charden
- Terraforming Mars
- The Singularity
- Tms
- Tor Browser
- Trance
- Transhuman
- Transhuman News
- Transhumanism
- Transhumanist
- Transtopian
- Transtopianism
- Ukraine
- Uncategorized
- Vaping
- Victimless Crimes
- Virtual Reality
- Wage Slavery
- War On Drugs
- Waveland
- Ww3
- Yahoo
- Zeitgeist Movement
-
Prometheism
-
Forbidden Fruit
-
The Evolutionary Perspective
Monthly Archives: July 2017
Two Gene Therapy Approaches Pending Approval from FDA Bring Hope to Mesothelioma Community – MesotheliomaHelp.org (blog)
Posted: July 27, 2017 at 9:45 am
Nearly five years ago, MesotheliomaHelp reported about a breakthrough treatment called gene therapy. At the time, it was touted as the next frontier in medicine, and cancer patients from around the world watched closely in the hopes that the treatment could bring a cure to even the rarest of cancers, such as mesothelioma. Now, all eyes are on the U.S. Food and Drug Administration as it is poised to approve two types of gene therapy.
The Oncologic Drugs Advisory Committee (ODAC) sent its recommendation to the FDA on July 12 for CTL019 (tisagenlecleucel) for the treatment of a form of leukemia. Then, on July 17, the FDA accepted a Biologics Licensing Application from Spark Therapeutics for gene therapy for a rare inherited eye disease that causes blindness, approved the name Luxturna for the treatment, and assigned priority status to the treatment for accelerated review.
To better understand these two pending landmark approvals and the future of gene therapy, MesotheliomaHelp turned to Ricki Lewis, a New York-based geneticist and author.
Its not right for every disease, said Lewis. But it is an approach that can be considered some day along with drugs, surgery and everything else.
Tisagenlecleucel is an investigational chimeric antigen receptor (CAR) T cell therapy from Novartis, developed by researchers at the University of Pennsylvania. The pharmaceutical company wants to use the therapy to treat a rare form of leukemia, B-cell acute lymphoblastic leukemia affecting children and young adults under the age of 25, according to NPR.
Lewis explains that CAR-T therapy is not conventional gene therapy, which has been in clinical trials to treat single-gene diseases since 1990. However, she notes that CAR T cell technology has had astonishing success in treating a form of leukemia and its being tested for multiple myeloma, brain cancer, breast cancer, and soft tissue cancers.
Although both approaches deliver DNA in viruses, classical gene therapy adds a working copy of a single mutant gene, restoring a specific proteins function, says Lewis. Revving up a not-naturally-occurring immune response isnt the same thing as replacing an enzyme, which is what Luxturna does.
According to the National Cancer Institute, in CAR-T treatment, T cells are removed from the patients blood and genetically altered in a lab to have chimeric antigen receptors on their surface. The T cells are then multiplied, into the billions, in the lab and infused back into the patients blood, where they seek out the cancer cells and launch a precise immune attack against them.
Lewis offers the following explanation of CAR-T:
CAR operates like a drone, targeting and obliterating cancer cells. It introduces a gene manufactured to contain instructions for making two immune system components in one, something that doesnt exist in nature: an antibody and a T cell receptor. When delivered in a virus, the CAR enters the persons T cells, which then manufacture the hybrid (chimeric) protein.
The engineered receptor portion guides the T cells to a specific target such as cancerous B cells where the antibody part binds. The action alerts the immune system to respond and kill the cancer cells.
Ultimately, CAR-T, also described as a process that genetically alters a patients own cells to fight cancer, could be used for many more diseases and cancers, and bring an effective treatment to mesothelioma patients.
In a 2013 article for MesotheliomaHelp, Lewis wrote about CAR-T treatment saying, An ingenious technique that has vanquished leukemia in a handful of patients is also being applied to mesothelioma.
Lewis highlighted the CAR-T process being used in a mesothelioma clinical trial from the University of Pennsylvania that uses the doctored T cells, known as chimeric immune receptor (CIR) instead of CAR, against mesothelin, a protein that is found to be in excess in mesothelioma and other cancers. The idea is that T cells led to the mesothelioma cells will attract an immune response, said Lewis.
Find out more about the mesothelioma clinical trial from the University of Pennsylvania here.
In her book The Forever Fix, Lewis followed the journey of the use of gene therapy to restore the vision of a young boy who was nearly blind from a hereditary disorder. The doctors added a working copy of a single defective gene in the New York boys eyes that prevented his eyes from using vitamin A to send visual signals to his brain. The treatment was a success: the boys vision was restored and no further treatments or surgery were required.
Last weeks FDA advisory committees greenlight for CAR technology overshadowed a milestone for what is likely to be the first approval of classic gene therapy for a form of inherited blindness, Lewis told MesotheliomaHelp. Thats the Leber congenital amaurosis type 2 renamed RPE65-mediated inherited retinal dystrophy that I wrote my book about.
In an interview with Lewis last week, Dr. Katherine High, MD, President, Chief Scientific Officer, and a founder of Spark Therapeutics, said of the future of gene therapy:
I hope we will see continued accumulation of successful clinical results in a range of target tissues and continued progress in bringing gene therapy products to licensing. When gene therapy products are licensed, there will be increased interest in the medical community, and that will help to expand opportunities.
Mesothelioma patients typically show disease symptoms years or even decades after exposure to asbestos, a known carcinogen. The cancer is eventually fatal, but aggressive therapy may prolong the lives of patients who are diagnosed early. Approximately 3,000 Americans are diagnosed with the cancer each year.
Getting at the basis of why one person develops mesothelioma and another person doesnt, that is going to hold a clue to really fighting it, Lewis said, referring to a clinical trial conducted at Wake Forest University in 2013 to determine whether some mesothelioma patients are genetically predisposed to developing mesothelioma. Then we will know what to do the gene therapy on.
The pending FDA approvals could bring groundbreaking treatment to cancer patients and to patients with genetic diseases. Perhaps someday, mesothelioma patients will enjoy long, productive lives through gene therapy.
The FDA is not bound to follow the ODACs recommendations, however, the Agency nearly always follows the recommendation. Approval for CTL019 is expected in November. The FDA will decide on Luxturna in January, 2018.
About Ricki Lewis,PhD Ricki Lewis is a science writer with a PhD in genetics. The author of several textbooks and thousands of articles in scientific, medical, and consumer publications, Rickis first narrative nonfiction book, The Forever Fix: Gene Therapy and the Boy Who Saved It, was published by St. Martins Press in March 2012. In addition to writing, Ricki provides genetic counseling for parents-to-be at CareNet Medical Group in Schenectady, NY and teaches Genethics an online course for masters degree students at the Alden March Bioethics Institute of Albany Medical Center.
Read more about gene therapy on Ricki Lewiss DNA Science blog.
Find out more about Ricki Lewis at her website.
See more here:
Two Gene Therapy Approaches Pending Approval from FDA Bring Hope to Mesothelioma Community - MesotheliomaHelp.org (blog)
Posted in Gene Medicine
Comments Off on Two Gene Therapy Approaches Pending Approval from FDA Bring Hope to Mesothelioma Community – MesotheliomaHelp.org (blog)
Far-right ‘trying to ruin the Government’s LGBT survey’ with false submissions – The Independent
Posted: at 9:45 am
Far-right trolls have been trying to distort the results of the Governments first LGBTsurvey.
The initiative, which was launched by the Government Equalities Office, is designed to be an opportunity for LGBT+ people to have their say on the future of the Governments equality policies.
More than 60,000 people have already responded to the consultation, which opened on Sunday and ends in October, but there are fears that it may be derailed by false submissions written by users of internet forum 4chan.
One user posted a link to the survey on the sites /pol/ section, where users post politically incorrect comments, and urged others to troll it with racist and homophobic responses.
Another user said people on the site should make sure to fill this in and f*** it up lads the 'conservative' party wants to bring in more anti freedom pro degenerate policies again [sic].
Another said: What a lot of people did yesterday was identifying as a Muslim transperson and pointing out anti LGBT behaviour in the Muslim community.
Other users said they should attempt to spread Islamophobia through the survey by creating an authentic LGBT person and blame all oppression on Muslims.
Others suggested sending obviously fake responses to the survey.
After being posted to 4chan, where users can post comments to its forums anonymously, the idea appeared to spread to neo-Nazi website Stormfront, PinkNews reported.
One said they had written living as a pedosexual [sic] ferret is rough guys and another said they were a level 28 gender druid.
The Government said it was aware that there were "fake" responses to the survey and is working to delete the false entries.
A spokeswoman for the Equality Office said the best way to combat the problem was for LGBT people to take the survey "so that any erroneous responses only ever make up a small proportion of the total".
Go here to read the rest:
Far-right 'trying to ruin the Government's LGBT survey' with false submissions - The Independent
Posted in Politically Incorrect
Comments Off on Far-right ‘trying to ruin the Government’s LGBT survey’ with false submissions – The Independent
Dozens of Venezuelan Journalists Flee Censorship and Violence to Report in Miami – Miami New Times
Posted: at 9:44 am
Nicols Maduro's regime has cracked down on the free press.
Photo by Marcos Salgado / Shutterstock.com
Alejandro Marcano stared into the camera and read the days news to millions of Venezuelan viewers on Globovisins 24-hour network. Suddenly, the studios windows erupted in a rain of glass. Gunshots ricocheted through the room. A militant colectivo that supported the government circled the lot and threw tear gas into the building. Marcano realized he had two choices: sprint through the gunshots or die of asphyxiation.
On that terrifying morning of January 1, 2009, Marcano chose to run and barely escaped the brazen attack on the TV station. But his career as a journalist in his homeland was over; nearly four months later, Marcano left Caracas for Miami.
His story is far from unusual. As Nicols Maduros repressive regime tries to consolidate power despite rising protests, independent journalists face even more danger than the average Venezuelan. Amid government crackdowns and violent threats, more than 100 reporters have fled to Miami in recent years, according to Sonia Osorio, resident of the Association of Venezuelan Journalists Abroad (APEVEX).
Many like Marcano have now set up shop in South Florida, where they fight from abroad to keep telling the story of their countrys desperate struggle. We need to be participants of history so this doesnt happen again in another country, Marcano says in Spanish.
From the moment he seized power in 1999, Hugo Chvez faced accusations that his Bolivarian Revolution violently stifled dissent. But it wasnt until 2002 that Chvez really began to crack down on the media. As the press reported ever more critically on his governments power grab, Chvez threatened to revoke broadcasting licenses from TV and radio stations. After suppressing a coup in 2002, Chvez blamed adversarial media and launched an all-out assault on the free press.
Technically, Venezuelas 1999 constitution guarantees freedom of expression. But in 2004, Chvez pushed through a law forbidding stories that incite or promote hatred, foment citizens anxiety or alter public order, or disrespect authorities. News organizations could comply or shut their doors. Meanwhile, the government began revoking broadcast licenses and acquiring media outlets, eventually controlling 13 television networks, more than 65 radio stations, one news agency, eight newspapers, and a magazine.
After Chvez died in 2013 and his acolyte Maduro took power, violence against journalists became commonplace. Instituto de Prensa y Sociedad, a Venezuelan organization that fights for freedom of speech and the press, reports 279 journalists have been attacked for their work between March and June of this year alone. Five journalists have been killed since the Bolivarian Revolution.
Marcano lived through that bloody history firsthand. A native of Carpano, an eastern coastal city of 200,000, the TV reporter joined Globovisin, a station that had long been a critical check on the government, in 1995. But after Chvez grabbed power, the network began practicing a degree of self-censorship.
The directors started putting on lighter programming, Marcano says. They started lowering the tone.
Still, Globovisin didnt stop critiquing the regime. Thats why the colectivo attacked the station in 2009 an assault that Marcano and his colleagues were certain was authorized by Chvezs government.
Alejandro Marcano, left, now reports on Venezuela from Miami
Courtesy of Alejandro Marcano
In recent years, journalists who buck the party line can face violent backlash. Orian Brito, an online and TV reporter, was visiting Miami in January of 2012 when he found a photo of children back in Caracas armed with heavy machine guns. He discovered the children were given the weapons by colectivos, with support of the government, and published his findings in Reportero 24, an online paper. Suddenly he faced the worst week of his life.
First, a state TV network, Venezolana de Televisin, began attacking him and airing his personal information. His bank accounts, Facebook and Twitter accounts, email, and phones were all hacked. His family received threats and was interrogated about where Brito got his information and photos.
Brito decided he couldnt risk returning to Venezuela. My family told me, Dont come back,? he says in Spanish. ?Dont come, because theres no guarantees. Something happens to you, and who responds? Who cares??
Other reporters say their families became targets when the government didnt like their work. Miguel Mundo was a reporter at Las Noticias de Cojedes, a Caracas newspaper, when he began writing about ties between a group of narcotraffickers and the government. After several stories, Mundos paper was bombed with Molotov cocktails. Then, in January 2012, Mundos wife was kidnapped from a gas station, beaten, and tortured until Mundo agreed to leave the paper. A few weeks later, he and his wife hopped a late-night flight to Miami with their children and applied for asylum.
There are still many professional Venezuelan journalists that maintain the will and the disposition to keep working amid everything thats happening in Venezuela, Mundo says in Spanish. Meanwhile the regime does everything to try to violate and force the journalists that try to do an ethical job in the country.
As mass protests have shaken Venezuela this year, the reporters who remain say the threat of violence is omnipresent. Miguelangel Caballero, a freelance journalist, says all journalists there take a risk.
Your life and physical integrity are in danger before the attacks of the government, the security officials, and the paramilitaries, called collectivos, that attack and rob the professionals of the press, Caballero says in Spanish.
Jos Ral Gerere, a 21-year-old journalist, has been producing stories through social media channels while working as a salesman at a mall. Gerere says it isnt always easy to get accurate information with all the commotion of the protests.
It is complicated and difficult, but in spite of everything, one must be extremely firm in the face of constant criticism, threats, or whatever they wish to do, Gerere says in Spanish.
Back in Miami, the journalists who have left say they feel an obligation to keep reporting. APEVEX, founded by Osorio and two other colleagues in 2013, helps reporters like Brito get back on their feet when they arrive. Osorio says they have 50 official members in Miami today.
Some have found work at ex-pat publications, like Mundo, who became a reporter at El Venezolano in Orlando. But that paper recently closed, so hes looking for work in Miami.
I came here a little reluctant to work in journalism, says Mundo in Spanish. I was stressed with what had just happened.
As for Marcano, hes made a new career in Miami out of reporting on the daily crisis unfolding in Caracas on Mart Noticias, the U.S.-government funded station that broadcasts into Cuba.
On a recent Thursday at the Mart studios in Doral, Marcano stands in a dressing room in a lilac button-down, patting the sweat from his shaved head under vanity lights. The makeup artist makes casual conversation with the two interviewees getting prepped for their time on camera.
How long have you been here? he asks. Theyre both from Venezuela. In this dressing room, Miami becomes a cemetery for the lives and professions left behind.
Once in the studio, Marcano can barely stay still as he directs his crew at lightning speed. He recounts stories before the recording begins, making his guests comfortable under the glare of a dozen white lights and three cameras.
The producer counts down in his earpiece, loud enough to emanate throughout the quiet room: Three, two, one. Marcano does the sign of the cross before he begins recounting the latest protests and crackdowns in his homeland.
Bienvenidos a Venezuela en crisis, he says.
The rest is here:
Dozens of Venezuelan Journalists Flee Censorship and Violence to Report in Miami - Miami New Times
Posted in Censorship
Comments Off on Dozens of Venezuelan Journalists Flee Censorship and Violence to Report in Miami – Miami New Times
Book banning in Academy School District 20: Censorship or diligence? – Colorado Springs Gazette
Posted: at 9:44 am
Academy School District 20 leaders removed a "young adult" book from a middle school library in an act of censorship or diligence, depending on whom you ask.
An appeal to lift the ban on "Perfect Chemistry," by Simone Elkeles, from the library at Challenger Middle School was denied, setting a dangerous precedent, said James LaRue, director of the Office for Intellectual Freedom, a unit of the Chicago-based American Library Association.
"It's not as if anybody was being forced to read the book," he said. "Let's not be so afraid about what's going on in the world that we discourage our children from reading."
D-20 board members said the issue is not one of freedom of speech, but rather doing their job to not expose young students to unsuitable adult topics.
Board members unanimously agreed at a July 20 meeting to uphold a superintendent designee's ruling that the book is "not age-appropriate for a middle school audience because of pervasive descriptions of graphic sexual encounters, drug/alcohol use, violence and use of profanity."
"This book should have never made it to the shelves of a middle school," said D-20 board member Larry Borland. "This is not about censorship; it's about a school system making a reasonable policy decision that the language, sexual content and violence in the book are inappropriate for children who are 11, 12 or 13."
A book review committee of professionals and parents from Challenger unanimously disagreed and appealed the decision. The superintendent's designee, Jim Smith, assistant superintendent for administrative services, initially agreed with the committee but later reversed that decision.
The group submitted a 92-page appeal to the board. The author also wrote a letter in defense of the book.
"This is a bigger issue than just one book," Challenger Middle School librarian Gina Schaarschmidt told the board.
"Librarians are required to provide materials for all students. A middle school has a wide range of maturing levels, and we must honor all of them."
Books deemed "young adult" have stickers indicating they are for eighth-graders or students 14 and older.
A parent of a sixth-grader had complained about bad language and sexual references in "Perfect Chemistry," described as a cross between Shakespeare's "Romeo and Juliet," the musical "West Side Story" and the movie "Grease."
The student, who was officially not old enough to obtain the book from school, had taken it and hid it from her mother, who found it under her pillow.
"Some of our students are ready for controversial content," said librarian Schaarschmidt. "They also know they should talk to their parents about the books. Different families have different sensitivities to controversial topics. Let parents choose for their own families."
The book has not been prohibited from high school libraries in D-20, the region's second-largest public school district with about 26,000 students.
The story, set in Chicago, depicts the relationship between an affluent white girl and a Hispanic boy, who wants to have sex with her as part of a gang initiation. The two become friends, talk about problems in their lives and fall in love.
The book explores how people from different backgrounds come to understand one another, exposing students to diversity issues and critical thinking, LaRue said.
"Parents don't want to confront the truth that their children are growing up," LaRue said. "By removing this book, you don't remove the problems from society - you make it harder for people trying to deal with it and find information that could help them."
D-20 board members said they find the book offensive in various ways.
"This book is one giant clich, one negative stereotype after another, constant sex, drugs and alcohol use by teenagers, which implies everyone does it, a lot of profanity, and the protagonists repeatedly make poor choices and it's OK," said board member Linda Van Matre.
Board President Glenn Strebe counted the number of times certain profane words and sexual references, such as masturbation, appear in the book. He read the list aloud, prompting a warning of caution on the online video of the meeting.
"Typically, at the American Library Association, we say you have the right to say, 'This is what I want my child to read,'" LaRue said. "What gets worrisome in the public environment is to say, 'I don't want anyone else to read this either.' That's what you do when you remove a library book."
Two other library books at Challenger also have been questioned and pulled, Schaarschmidt said, and the parent who started the action has requested an inventory of all books in the school library.
To parents who criticize bad language and sexual references in teen books, LaRue responds: "Do they watch TV? Are we saying there is no sex and no swearing in public schools? When someone writes a book, they try to make it realistic. I always say it's safer to run across a problem in a book than it is to find out about it on the streets for the very first time."
View original post here:
Book banning in Academy School District 20: Censorship or diligence? - Colorado Springs Gazette
Posted in Censorship
Comments Off on Book banning in Academy School District 20: Censorship or diligence? – Colorado Springs Gazette
‘Indecent’ Playwright Paula Vogel Calls David Mamet’s Talkback Ban ‘Censorship’ – Forward
Posted: at 9:44 am
2Pac vs. Biggie. Elizabeth I. vs. Mary, Queen of Scots. The Jets vs. The Sharks.
Add to the list: Jewish American playwright David Mamet vs. Jewish American playwright Paula Vogel. There will be blood. And there will also be strongly worded New York Times quotes.
How did the grudge between these two great households, both alike in dignity and Pulitzer prizes, begin?
It was discovered recently that David Mamet, known for clipped dialogue in works like Oleana, has instituted a clause through his licensing company which prohibits theaters producing his work from sponsoring post-show talks within 2 hours of performances. The penalty? A cool $25,000 fine. In other words, theaters would have to throw around a significant amount of their operating budgets to hear questions like, How did the actors memorize all those lines?
Mamets given reasoning is that he wanted the impact of his play not to be emotionally truncated by a structured discussion between the actors and their audience. This is not a surprising sentimentin my experience David Mamets plays, which range from blundersome to scorchingly brilliant, all give off a vibe of a creepy uncle who lives to monologue to young women. But is this prohibition censorship?
Yes, according to firebrand playwright and professor Paula Vogel, who would know, since she literally wrote the play on censorship. The acclaimed Indecent, a meditation on Jewish art, history, and censorship, which was resuscitated by enthusiastic audiences after poor ticket sales threatened its shuttering, is currently running on Broadway. Vogel told the New York Times that she enjoys talk backs for her own and others plays, and that they can range from painful to Dr. Ruth dancing in the aisles. Of Mamets ban she said:
The gauntlet, it seems, has been thrown. When will Mamet and Vogel meet for a gentlemens duel? When will we be privy to a Pulitzer-worthy rap battle? Is there any chance of a dance-off, or perhaps, a one-act-off?
As we wait for Mamet to respond to Vogels diss, we issue a challenge of our own: the theater that produces a David Mamet play, throws a two-hour-and-one-minute happy hour, and then opens the floor to a raucous, drunken talkback is the theater that may save the American arts establishment from itself.
If you are a theater with a plan like this, please call us. And more importantly, invite us.
Jenny Singer is a writer for the Forward. You can reach her at Singer@forward.com or on Twitter @jeanvaljenny.
Original post:
'Indecent' Playwright Paula Vogel Calls David Mamet's Talkback Ban 'Censorship' - Forward
Posted in Censorship
Comments Off on ‘Indecent’ Playwright Paula Vogel Calls David Mamet’s Talkback Ban ‘Censorship’ – Forward
Venezuelan Journalism Students Are Fighting Media Censorship. Here’s How You Can Help – Remezcla (blog)
Posted: at 9:44 am
Over the past decade and half, the streets of Venezuela have become a battlefield for journalists. This year, the country came third-to-last in the2017 World Press Freedom Index, withindependent NGO Reporters Without Borders (RSF) naming Venezuelas situation difficult. The independent medias virtual blocking from official sources, and the active persecution practiced by Nicols Maduro and his government and Hugo Chvez before him against critical voices, are some of the biggest obstacles these professionals face.
The examples are many just read about Chilean-Venezuelan political prisoner (now on house arrest) Braulio Jatar, or New York Times reporter Nicholas Casey, who wasbanned from the country in October 2016.Reports abound of the countless arbitrary arrests and assaults suffered by reporters, camera crews, and photographers in the recent protests against Maduro and his constituent assembly referendum.
The shift in how information is shared in Venezuelas mass media can be traced back to Chvezs silencing of TV station RCTV 20 years ago. A large percentage of TV & radio stations and print publications are now government-owned, and only share what Venezuelans have come to know as the official version of events; the majority of the remaining private outlets recur to self-censorship in order to stay out of trouble.
This means Venezuelas citizens have practically just one place where they can find out whats going on in their own country: the Internet. And here too, there are obstacles. Venezuela has the slowest internet connection in Latin America, and a penetration of just 53% of which only 2% represent low-income communities. Right now, its becoming more and more common for opposition politicians to broadcast their press conferences on Periscope, for example, or to witness police enforcement excesses on Facebook Live transmissions.
In the context of these past 100+ days of protests, a group of journalism students from Montevila University, in Caracas, have stepped in to try and fight journalisms good fight. They turned their thesis into El Tambor a full-fledged independent online news medium, which uses tools like infographics, videos, photos, and animations targeted to millennial audiences. What began as a four person outfit is now a team of 45 young people based in Caracas and an Instagram account with over 70,000 followers with a passion and a sense of duty to keep their fellow Venezuelans informed.
Their special coverage of the almost-daily demonstrations that have been going on in Caracas has required them to remain on the frong lines, which means their reporters are often risking their lives in the middle of violent actions from police, military, and even paramilitary groups. Thats why El Tambor has started a crowdfunding campaign to acquire equipment to protect themselves in these situations, like gas masks, bulletproof vests, safety helmets, as well as additional technology to keep doing their job.
We spoke to Jorge Lander, co-founder of El Tambor, to learn about their experience as an independent news medium the social turmoil of todays Venezuela.
What are some of the obstacles journalists face today while doing their job in Venezuela? Every day when we go out to cover the demonstrations in Venezuela, we have to wear bulletproof vests, gas masks, safety helmets, and we have to identify all of our equipment with press tags to ID ourselves. Still, three of our reporters have been assaulted by both government police forces and by violent paramilitary groups looking to stop us from doing our job. Despite all these threats, we remain determined, informing our citizens and the rest of the world about whats going on, because thats our role as journalism students.
How has the experience been for the El Tambor members covering these ongoing 100+ days of protests? Going out to do coverage gives us mixed feelings and emotions. At one moment, youre photographing a protest full of chants and posters against the government, and minutes later you start seeing people badly hurt because of repression by police enforcement officers. We risk our lives doing our job because, with this censorship and lack of information, our society needs us. In spite all of this, seeing the final result seeing the debates generated by the news and knowing that our audience is thinking critically about what we post, makes us proud and gives us strength to go on.
In this particular moment, whats the importance of online media outlets like yours which inform about whats going on in Venezuela? In the middle of the censorship we experience in Venezuela, digital media has been fundamental for sharing whats going on here. Thats why the responsibility we assume as a medium is increasingly bigger; were committed to the country, and thats why all the information we post on our website and social media is rigorously confirmed. Weve witnessed how people are trusting online media more and more; theyre basically the only windows Venezuelans have to know whats going on in the country.
As journalism students, how do you see the future of your profession in a country like yours? We face Venezuelas situation with optimism. We believe deeply that there will be a positive change in our country, politically and socially speaking. Thats why we keep working with care, using the few resources we have at hand, and always fighting to overcome the obstacles. Because we know were responsible for building the future of our country; its in our hands to build tomorrows journalism. We firmly believe well be pioneers in communications here and, amidst the crisis, we see a space for learning and opportunities that will guide us to a bright future.
Donate here to support El Tambors crowdfunding efforts.
.
Posted in Censorship
Comments Off on Venezuelan Journalism Students Are Fighting Media Censorship. Here’s How You Can Help – Remezcla (blog)
Is Star Trek Icon William Shatner a Libertarian? – The American Conservative
Posted: at 9:43 am
William Shatner at FreedomFest 2017 in Las Vegas Friday night. Credit: Emile Doak/The American Conservative
Is there a free mind? Are our minds free? Are we programmed by something up there to follow our fate? Or are we programmed by Mom and Dad at a very early age? So is there free will? Do we make choices?
So wondered William Shatner during his July 21 speech at the annual Las Vegas convention of libertarians and other free-marketeers called FreedomFest. He urged the audience to stick to its principles, not compromise as he says he did when he directed Star Trek V by giving up on his original vision of having the real God attack the crew with an army of lava men in the films climax.
Compromising principles is a mistake, suggested Shatner. Nobody can tell you what to do. Somewhere inside us is a core.
Is William Shatner a libertarian, you might ask? If not, whats he doing there? Well, it seems more like hes an environmentalist worried about overpopulationand hes a Canadian, of coursebut hes also expressed some populist longings for someone to sweep away the bureaucrats and make American democracy work again. And he avoids commenting on Donald Trump. Maybe call Shatner a frustrated technocratic populist? Sounds like sort of a Reform Party guy to me, leavened by an inevitable Star Trek-veteran love of science and education.
None of this makes him too much weirder than a previous FreedomFest speaker who went on to bigger things, namely Donald Trump. I suppose the question is how big you want the libertarian tent to be. You probably want a tent big enough to let in optimists who still believe we can invent and build things, but not a tent so big that it lets all the carny-barkers inside. A friend of mine in Colorado reports seeing someone flying around downtown Denver with a jetpack a couple weeks ago, so we know futuristic technological progress is officially going strong, but I worry more about unrealistic promises in politics these days.
I noticed some people joking online that theyd love to hear Shatner tell the assembled libertarians to get a life in the fashion of his notorious 1986 Saturday Night Live sketch about obsessive Trekkie conventioneers. I probably would have laughed harder at that joke myself a decade or two ago, when it seemed that the worst thing that could happen to the libertarian movement is that it might get too screechy and radical and alienate mainstream Americans. Everybody relax, I would have thought.
Nowadays, I worry more that in American politics, even the most radical road always leads back to the same mushy centrist middle, with a few highly predictable TV pundits guarding that middle against the emergence of any truly new ideas. So, if Shatner is unlikely to express a precise, coherent philosophical argument, I should at least root for him to leave crowds slightly confused, even if he says something stupid. That can spur thought. It beats sticking to safely-ambiguous, nigh-universal sentiments that are deployed as if to build coalitions but are really used mainly to make the speaker himself seem as non-threatening as possible, often boosting his career without doing much to shore up the hypothetical broader coalition. Absent utopian unanimity, one should root for competition, always.
Im beginning to feel the same way about fictional continuity in Star Trek, to my surprise.
A sci-fi geek, I have been as eager as anyone over the years to see massive fictional continuities like that of the Star Trek universe or the DC Comics universe kept perfectly consistent. Inevitably, though, things fall apart eventually. New writers and new producers like Star Trek/Star Wars director J.J. Abrams come along and cavalierly decide theres a certain scene they want to depict or a character they want to bring back, and out goes the whole timestream as were asked to pretend vast swaths of prior fictional history never happened. I used to think this process was as heartbreaking as watching footage of the old Penn Station being demolished.
But there comes a point when you realize that the hope of maintaining a consistent continuityor a large political coalitionis probably rooted in a misguided optimism. The editors are too busy to care about all the details, and the politicians and most popular pundits are too busy or corrupt to care about philosophical purity. So, then the disappointed idealist starts to root for chaos. Perhaps thats a little of what happened in November 2016.
Let my fellow libertarians fight viciously and devolve into factions (pausing to enjoy the occasional near-meaningless Shatner speech or other entertainment). Like small and decentralized states, the factionalism might afford a better chance for truth to survive out there somewhere than would one bland, homogeneous consensus version of the philosophy with all the rough edges polished and gleaming.
And if the new Star Trek: Discovery TV series comes out this fall and has a throwaway line in it suggesting that this timeline may replace both the Abrams films and all the TV material we know from the 60s and 90s, well, now Im okay with that possibility, too. I am preemptively embracing that anarchic conclusion before the monarchShatnerhas a chance to insult us all again. Let a hundred Omicron Ceti III flowers bloom.
In Vegas terms, until we really hit the jackpot, Im grateful so long as we can keep rolling the dice.
Todd Seavey is the author of Libertarianism for Beginners. He writes for SpliceToday.com and can be found on Twitter at @ToddSeavey.
Read the original post:
Is Star Trek Icon William Shatner a Libertarian? - The American Conservative
Posted in Libertarianism
Comments Off on Is Star Trek Icon William Shatner a Libertarian? – The American Conservative
Salvation in Transhumanism: Humanity merges with machines and lives for ever – ZDNet
Posted: at 9:41 am
From left: Chris Conatser, Allison Page, Kevin Whittinghill, Zoltan Istvan and Allen Saakyan
Zoltan Istvan ran for President of the US as a "Transhumanist" with a campaign that called for massive government funding to eliminate human mortality. Donald Trump won with a much crazier campaign.
Earlier this week on the Eureka science show he talked about Transhumanism and his campaign to become California Governor in 2018.
Digital Transformation: A CXO's Guide
Reimagining business for the digital age is the number-one priority for many of today's top executives. We offer practical advice and examples of how to do it right.
The hosts Allen Saakyan and Kevin Whittinghill were joined by comedians Chris Conatser and Allison Page. The show uses comedy to educate its audience about important scientific issues.
No foodies...
You can tell by the expressions on their faces (photo above) that Istvan's description of Transhumanism and the chance to live hundreds of years wasn't very appealling. Especially the part when he said that we won't need sex or food in a future Transhumanist world.
Istvan looks like a TV presenter because he used to be one -- at National Geographic. And it was on assignment in Vietnam when he almost stepped on a landmine that he vowed to work on ending human mortality.
Excerpts from Istvan's talk:
- Initially we'll be able to extend our lifespans by 500 years or so. [Like Zeno's paradox we won't catch up with our mortality]
- Ageing will be treated and eliminated like any other chronic disease.
- Our organs will be replaced with fresh ones grown from our own cells so there is no rejection and no lifetime medications.
- Machines of various types and sizes will be embedded in our bodies to protect, heal and augment our senses.
- A bionic eye will replace one of our natural eyes and allow us to see beyond the tiny 1% of the light spectrum so that we can see things like carbon monoxide gas - useful for avoiding pollution.
- CRISPR will allow people to change their DNA to look like the people in the Star Wars bar scene - with tails and fur. [Costume shops - the disruption is coming.]
- Sex won't be anything like as we know it and might not even require other people.
- Eating and food won't be the same. Some Transhumanists want skin with chlorophyll. Lunchtime won't require a sandwich -- slip your shirt off and take a walk in the sun.
- Life extending technologies will come down in price and trickle down to the poorest of the poor.
I asked Istvan what will we be doing during our extra 500 years of life especially since our prime motivators of food and sex won't be present. He said this is the million dollar question, "We don't know."
I rephrased it and asked how will you spend the time? He said he would head back to school and pick up four doctorates and also learn how to play a bunch of musical instruments. That leaves 470 years to go...
Life is cheap...
As the last people were leaving the event a 42 year old man was shot dead outside the club. Transhumanism needs to address morality as well as mortality.
What an ironic commentary: we talk about the need for expensive transhumanist technologies to extend a person's life -- but a bullet bought for pennies has the final say. Stopping gun violence extends lives.
- - -
More info:
600 Miles in a Coffin-Shaped Bus, Campaigning Against Death Itself
Eureka show
Eureka Youtube channel
More here:
Salvation in Transhumanism: Humanity merges with machines and lives for ever - ZDNet
Posted in Transhumanist
Comments Off on Salvation in Transhumanism: Humanity merges with machines and lives for ever – ZDNet
Scientists genetically modify a human embryo for the first time – New York Post
Posted: at 9:41 am
For the first time ever, American scientists have successfully edited the DNA of a human embryo in the attempt to correct genes that cause inherited diseases, a report says.
Researchers from Oregon Health and Science University in Portland managed to modify numerous one-cell embryos using a controversial technique called CRISPR, according to MIT Technology Review.
Sources told the school magazine that the team, led by US-based biologist Shoukhrat Mitalipov, was able to safely inject gene-editing chemicals into human eggs near the moment of fertilization.
While the embryos were not allowed to be developed for more than a few days, the researchers ultimately proved that they could be efficiently edited in the attempt to correct genetic disorders.
Up until now, China was the only known country to carry out the practice. But they only managed to make their desired DNA changes on a small number of cells, creating an effect known as mosaicism.
Experts describe this as a condition in which cells within the same person have a different genetic code or makeup.
Mitalipovs team, however, was able to prevent this from happening.
They significantly reduced mosaicism, explained one researcher, who chose to remain anonymous.
The milestone means scientists in the US are officially one step closer to engineering the first genetically modified human beings on earth.
It is proof of principle that it can work, the researcher said. I dont think its the start of clinical trials yet, but it does take it further than anyone has before.
Go here to see the original:
Scientists genetically modify a human embryo for the first time - New York Post
Posted in Post Human
Comments Off on Scientists genetically modify a human embryo for the first time – New York Post
Scientists are building DNA from scratch to redesign life – New York Post
Posted: at 9:41 am
NEW YORK At Jef Boekes lab, you can whiff an odor that seems out of place, as if they were baking bread here.
But he and his colleagues are cooking up something else altogether: yeast that works with chunks of man-made DNA.
Scientists have long been able to make specific changes in the DNA code. Now, theyre taking the more radical step of starting over and building redesigned life forms from scratch. Boeke, a researcher at New York University, directs an international team of 11 labs on four continents working to rewrite the yeast genome, following a detailed plan they published in March.
Their work is part of a bold and controversial pursuit aimed at creating custom-made DNA codes to be inserted into living cells to change how they function or even provide a treatment for diseases. It could also someday help give scientists the profound and unsettling ability to create entirely new organisms.
The genome is the entire genetic code of a living thing. Learning how to make one from scratch, Boeke said, means you really can construct something thats completely new.
The research may reveal basic, hidden rules that govern the structure and functioning of genomes. But it also opens the door to life with new and useful characteristics, like microbes or mammal cells that are better than current ones at pumping out medications in pharmaceutical factories, or new vaccines. The right modifications might make yeast efficiently produce new biofuels, Boeke says.
Some scientists look further into the future and see things like trees that purify water supplies and plants that detect explosives at airports and shopping malls.
Also on the horizon is redesigning human DNA. Thats not to make genetically altered people, scientists stress. Instead, the synthetic DNA would be put into cells, to make them better at pumping out pharmaceutical proteins, for example, or perhaps to engineer stem cells as a safer source of lab-grown tissue and organs for transplanting into patients.
Some have found the idea of remaking human DNA disconcerting and scientists plan to get guidance from ethicists and the public before they try it.
Still, redesigning DNA is alarming to some. Laurie Zoloth of Northwestern University, a bioethicist whos been following the effort, is concerned about making organisms with properties we cannot fully know. And the work would disturb people who believe creating life from scratch would give humans unwarranted power, she said.
It is not only a science project, Zoloth said in an email. It is an ethical and moral and theological proposal of significant proportions.
Rewritten DNA has already been put to work in viruses and bacteria. Australian scientists recently announced that theyd built the genome of the Zika virus in a lab, for example, to better understand it and get clues for new treatments.
At Harvard University, Jeffrey Way and Pamela Silver are working toward developing a harmless strain of salmonella to use as a vaccine against food poisoning from salmonella and E. coli, as well as the diarrhea-causing disease called shigella.
A key goal is to prevent the strain from turning harmful as a result of picking up DNA from other bacteria. That requires changing its genome in 30,000 places.
The only practical way to do that, Way says, is to synthesize it from scratch.
The cutting edge for redesigning a genome, though, is yeast. Its genome is bigger and more complex than the viral and bacterial codes altered so far. But its well-understood and yeast will readily swap man-made DNA for its own.
Still, rewriting the yeast genome is a huge job.
Its like a chain with 12 million chemical links, known by the letters, A, C, G and T. Thats less than one-hundredth the size of the human genome, which has 3.2 billion links. But its still such a big job that Boekes lab and scientists in the United States, Australia, China, Singapore and the United Kingdom are splitting up the work. By the time the new yeast genome is completed, researchers will have added, deleted or altered about a million DNA letters.
Boeke compares a genome to a book with many chapters and researchers are coming out with a new edition, with chapters that allow the book to do something it couldnt do before.
To redesign a particular stretch of yeast DNA, scientists begin with its sequence of code letters natures own recipe. They load that sequence into a computer, then tell the computer to make specific kinds of changes. For example, one change might let them rearrange the order of genes, which might reveal strategies to make yeast grow better, says NYU researcher Leslie Mitchell.
Once the changes are made, the new sequence used as a blueprint. It is sent to a company that builds chunks of DNA containing the new sequence. Then these short chunks are joined together in the lab to build ever longer strands.
The project has so far reported building about one-third of the yeast genome. Boeke hopes the rest of the construction will be done by the end of the year. But he says it will take longer to test the new DNA and fix problems and to finally combine the various chunks into a complete synthetic genome.
Last year, Boeke and others announced a separate effort, what is now called Genome Project-write or GP-write. It is chiefly focused on cutting the cost of building and testing large genomes, including human ones, by more than 1,000-fold within 10 years. The project is still seeking funding.
In the meantime, leaders of GP-write have started discussions of ethical, legal and social issues. And they realize the idea of making a human genome is a sensitive one.
The notion that we could actually write a human genome is simultaneously thrilling to some and not so thrilling to others, Boeke said. So we recognize this is going to take a lot of discussion.
Link:
Scientists are building DNA from scratch to redesign life - New York Post
Posted in Post Human
Comments Off on Scientists are building DNA from scratch to redesign life – New York Post







