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Monthly Archives: July 2017
Nootropics | Our Favorite Nootropics Supplements
Posted: July 20, 2017 at 3:21 am
NooCube is TSR.orgs #1 ranked Nootropic brain supplement. It contains the highest quality, most clinically studied and most potent ingredients among all the supplements in this category.READ THE REVIEW
Brain Pill is a new supplement on the nootropic scene that has made some waves.We believe it certainly deserves the attention it has been getting and we ranked it high on our list. Check out this Brain Pill review to learn whyit earned its spot anda few of its shortcomings that prevented it from being #1. READ THE REVIEW
Addy Focus is a unique supplement that should have been invented a long time ago. It is exactly what it sounds like: an alternative to the drug Adderall. Can you really experience the benefits of Adderall without needing a prescription or having to suffer from the side effects? Check out this review to learn how Addy Focus makes it possible.READ THE REVIEW
Lumonol is without a doubt one of the best brain supplements on the market. It uses a combination of very potent and proven ingredients that makes for a super powerful formula. Based on the high overall potency, positive user experiences, and high quality formula, this is definitely a solid bet when it comes to brain supplements. It may not be #1, but it certainly earned its spot on the top 10 list.READ THE REVIEW
Geniux is a brain supplement that has been getting a lot of attention lately because of its apparent ability to improve brain function and cognitive performance. But just because of its widespread popularity, it is at the bottom of our top-1o list for a reason. Checkout this Geniux review to learn why.READ THE REVIEW
OptiMind is by far one of the most popular brain supplements on the market. We certainly consider it to be one of the ten best brain supplementsbut it failed to crack the top 5. Read this OptiMind review todiscover the positives and the negatives. READ THE REVIEW
Alpha Brain is one of the top 10 brain supplements on the market because of the high quality ingredients, diverse formula, and wide array of benefits. Its certainly a good supplement, but is it the best? Read this Alpha Brain review to find out why it made the top 10 but didnt crack the top 5. READ THE REVIEW
Adderin is another supplement designed to mimic the effects of the A.D.D. drug, Adderall. Is it possible for a natural supplement to work as well as Adderall? Read this Adderin review to find out just how effective it is and why it rankedwhere it did in our list. READ THE REVIEW
Smart Pill, by Only Natural, is one of the many brain supplements out there that claims to be able to boost overall function and cognitive performance, but does it live up to the claims?Though it deserves a top-ten ranking, it is far removed from the best of the best.READ THE REVIEW
Smart X is ranked #2 in our top 10 list because it is loaded with proven ingredients, and in high potencies. This popular brain supplement won the Best Brain Supplement of 2015. Find out why it didnt rank #1.READ THE REVIEW
Brain Pill is a new supplement on the nootropic scene that has made some waves.We believe it certainly deserves the attention it has been getting and we ranked it high on our list. Check out this Brain Pill review to learn whyit earned its spot anda few of its shortcomings that prevented it from being #1. READ THE REVIEW
CogniMaxxXL is a brain supplement formula that according to the manufacturer claim, gives the best brain of your life especially if your age is above 40.The manufacturerdeclares that their proprietary cognitive enhancer improves memory, the ability to focus and improves overall concentration. And for the most part, we agree.READ THE REVIEW
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Every Entrepreneur Needs Flow. Nootropics Can Get You There. – Entrepreneur
Posted: at 3:21 am
Weve all savored being in the zone: creative thoughts flow from brain to fingertips, timelessness, perhaps even an experience of euphoria. This elevated state of consciousness is the secret behind many outstanding athletes, daredevils, artists and entrepreneurs. It has a name -- flow -- given to it by psychologist Mihaly Csikszentmihalyi.
You can harness thepower of flow.
Entrepreneurs trying to break the status quo need to be better than average. Innovations and breakthroughs arent exclusivelythe result of hard work and hustle, especially as machines and computers take over monotonous tasks. Entrepreneurs need creativity to excel and develop new technologies.
Sixty percent of CEOspolled by IBM ranked creativity as the most important leadership quality. Entrepreneurs seeking flow must have the right environment and lifestyle habits but there are nootropics (aka cognitive enhancers) that can change the biochemistry of our brain to achieve flow more easily.
Related:The Happiest People Know Their 'Flow State.' What's Yours?
Since Mihaly Csikszentmihalyi labeled and analyzed flow states, it has become a hot topic for performance enhancement.
As Steven Kotler and Jamie Wheals book, Stealing Fire: How Silicon Valley, the Navy SEALs, and Maverick Scientists Are Revolutionizing the Way We Live and Work shows, high performance individuals are using flow enhancing techniques across the board.These mental states are the objective of high performers from Sergey Brin and Google executives to elite special forces.
The benefits of achieving flow states are manifold. Military researchers found that flow states can increase learning ability up to 230 percentin novice snipers. McKinsey researchers studied top executives for 10 years and found they were five times more productive in flow states.
Imagine working on a business venture with fivetimes the productivity and the ability to learn new materials 230 percentquicker than your competition. That alone would make flow states advantageous, but the true benefit is for creativity.
In 2013, phase one of the Red Bull Hacking Creativity Project started as a joint effort between MIT Media Lab, a group of TED fellowsand other flow experts to better understand creativity and flow states.
In late 2016, after reviewing more than 30,000research papers and interviewing hundreds of subject-matter experts, the project reached two conclusions. First, creativity is essential for solving complex problems. Second, creativity is less of a skill and more of a state of mind: i.e: a flow state.
Oliver Braithwaite, founder of the private tuition company Stars & Catz Teacher Network, said: Many of our students are executives who wish to take up a musical instrument to take their minds off work, de-stress and be creative. In part, what theyre seeking is actually a state of flow, where all other thoughts are suspended, stress drops away and creativity kicks in. Personally, as both an entrepreneur and a musician, Im aware that my most creative and effective work comes when enjoyment, creativity and focus coexist. Thats how Id define being in flow.
Related:How to Achieve aStateof Total Concentration
If flow states were easy to achieve, wed all be using them nonstop. There are environmental, psychologicaland emotional factors that affect to our ability to achieve flow regularly.
As new evidence and technologies come online, we better understand the neurochemistry of flow states and how to achieve it, including through supplements.Steven Kotler, author and flow researcher, recounted a simple flow hack using many commonly found techniques.
20 - 25 minute jog to release endorphins.
A cup of coffee -- caffeine for brain chemicals called dopamine and norepinephrine.
Marijuana -- THC provides a chemical called anandamide used for lateral thinking.
According to Kotler, this essentially mimics the neurochemistry of a flow states. It isnt sustainable, but it is a quick hack into this mental space (assuming you live in a part of the world where THC is legal).
Related:Mexico Joins Canada In Making Cannabis Legal, Leaving the US Far Behind in Marijuana Policy.
Aside from this clearly defined formula, there are a host of other substances utilized for creativity and achieving flow.
The term entheogen refers to psychoactive compounds, including LSD, psilocybin and mescaline, among others. Literally meaning generating the divine within, these compounds have been used in traditional cultures for thousands of years.
Even though many are illegal in the western world, entheogens like LSD and psilocybin are experiencing a resurgence of interest and research. Before these substances were made illegal, researcher James Fadiman conducted experiments using entheogens to enhance problem solving.
Within the experiment, 27 individuals (including engineers, mathematicians, architects, and engineer-physicists) were told to bring a problem they had been struggling with for months. Using small doses of mescaline, 44 percentof the cohort found breakthrough solutions (including patents and tangible technologies).
Entheogenic compounds have gone unstudied for decades, but the newfound interest is already bearing fruit. A brain imaging study conducted at Imperial College London by Dr. Carhart-Harris suggests regions of the brain associated with creativity are affected under the influence of entheogenic compounds.
From Silicon Valley to Wall Street, top executives are microdosing psychedelics to produce flow states, hack creativity, and produce breakthrough innovations. While these compounds are still illegal, there is some hope that will change over time.
Related:Tim Ferriss: If You're Not Happy With What You Have, You Might Never Be Happy
The drawback to nootropics and cognitive enhancers isthe lack of scientific evidence and minefield of snake oil salesman. Many of the purported smart drugs are no more useful than the placebo effect while others come with unnecessary side effects.
Self experimentation becomes key for entrepreneurs trying to enhance flow states and creativity. When I visited the Peak Brain Institute in Los Angeles to perform a QEEG brain map, we found a synthetic nootropic called phenylpiracetam enhanced brain waves associated with flow states. Neuroscientist Dr. Andrew Hill confirmed the cognitive boost providing empirical evidence this smart drug works for me.
Finding nootropic concoctions to achieve flow states need not be scary, riskyor challenging. For risk averse beginners, simply taking L-theanine (an amino acid found in green tea) with your morning cup of coffee can increase alpha brain waves, which are associated with flow states.
Related:3 Surprising Ways to Unlock Your Creativity
Entrepreneurs servethe world by creatinguseful innovations and technology. To solve global problems, entrepreneurs must be able to achieve more creative flow states and do so more consistently.
Through nootropic supplementation and innovative technologies, we can now achieve flow more readily to create more value and wealth in our businesses.
Mansal Denton is an entrepreneur and self explorer currently developing Nootropedia, which offers unbiased and accessible information to improve mental performance. He enjoys active hobbies, including hiking and jiu-jitsu, as well as quiet...
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NETCENTS Integrates Top Tier Merchants Within the Nutraceutical Sector – Canada NewsWire (press release)
Posted: at 3:21 am
VANCOUVER, July 19, 2017 /CNW/ -NetCents Technology Inc. ("NetCents" or the "Company") (CSE: NC) is pleased to announce the rapid expansion of its merchant portfolio, further validating the company's robust suite of eCommerce-based plugins; such as WooCommerce and Magento (See news May 23, 2017 and July 5, 2017).
The latest fully integrated, additions to NetCents' diverse merchant base include four, top tier market leaders within the burgeoning Nutraceutical vertical. Since the successful integration of these four merchant-partners, NetCents has realized a significant boost in both active users and transactional volumes.
Automated, onboarding processes have facilitated the accelerated growth of NetCents' merchant portfolio. These processes allow prospective merchants to realize a practically instantaneous integration into the NetCents Gateway. One of the preeminent features of the NetCents' platform is its ability to immediately onboard merchants through its low-touch online gateway.
"NetCents has created revolutionary, low touch, high growth merchant integration procedures. This is because of our fully automated merchant application and on-boarding process. We have completely streamlined the merchant integration process by removing non-value added activities," said Clayton Moore CEO & Founder, NetCents Technology Inc.
Another prominent feature of the NetCents' platform is the company's AI 2.0 proprietary processing algorithm, pre-validation of transactions before the final transaction is processed with the merchant. "This process eliminates 99.9% of all chargeback related events, which is a multi billion-dollar problem," said Clayton Moore CEO & Founder, NetCents Technology Inc. "The NetCents solution opens up a huge market opportunity, particularly in industries where merchants are labelled as high risk. The Nutraceutical industry in the most part has been deemed high risk where payment processing has not been available to these merchants. NetCents' cryptocurrency processing allows these online merchants the ability to conduct business and allowing NetCents the opportunity to corner lucrative markets such as Nutraceuticals for payment processing."
NetCents will be providing updates on these events in the coming weeks with more detailed information.
The cognitive enhancement supplement industry also called Nootropics or smart supplements are drugs, supplements, or other substances that improve cognitive function, particularly executive functions, memory, creativity, or motivation, in healthy individuals.
"Global Nootropics Market To Reach Over USD 6 Billion By 2024" according to the latest report published by Credence Research, Inc. "Nootropics Market - Growth, Future Prospects and Competitive Analysis, 2016-2024," the global Nootropics market was valued at USD 1.3 Billion in 2015, and is expected to reach over USD 6 Billion by 2024.
If your company or organization wishes to integrate the NetCents platform into your website, visit http://www.netcents.biz and click on our "Payment Gateway" tab to complete the online form to get the digital integration process started. A NetCents payment icon will be placed on your website at no cost.
About NetCents
NetCents is a next generation online payments processing platform, offering consumers and merchants online services for managing electronic payments. The Company is focused on capturing the migration from cash to digital currency by utilizing innovative Blockchain Technology to provide payment solutions that are simple to use, secure and worry free. NetCents works with its financial partners, mobile operators, exchanges, etc., to streamline the user experience of transacting online. NetCents Technology is integrated into the Automated Clearing House ("ACH") and is registered as a Money Services Business (MSB) with FINTRAC, which ensures our consumer's security and privacy. NetCents is available for deposits from 194 Countries around the World, providing you with the freedom to choose to Pay. Your Way.
On Behalf of the Board of Directors NetCents Technology Inc.
"Clayton Moore"Clayton Moore, CEO, Founder and Director
NetCents Technology Inc. Suite 880, 505 Burrard St (Bentall 1), Vancouver, BC, V7X 1M4
Cautionary Note Regarding Forward Looking Information
This release includes certain statements that may be deemed "forward-looking statements". All statements in this release, other than statements of historical facts, that address events or developments that the Company expects to occur, are forward-looking statements. Forward-looking statements are statements that are not historical facts and are generally, but not always, identified by the words "expects", "plans", "anticipates", "believes", "intends", "estimates", "projects", "potential" and similar expressions, or that events or conditions "will", "would", "may", "could" or "should" occur. Although the Company believes the expectations expressed in such forward-looking statements are based on reasonable assumptions, such statements are not guarantees of future performance and actual results may differ materially from those in the forward-looking statements. Factors that could cause the actual results to differ materially from those in forward-looking statements include regulatory actions, market prices, and continued availability of capital and financing, and general economic, market or business conditions. Investors are cautioned that any such statements are not guarantees of future performance and actual results or developments may differ materially from those projected in the forward-looking statements. Forward-looking statements are based on the beliefs, estimates and opinions of the Company's management on the date the statements are made. Except as required by applicable securities laws, the Company undertakes no obligation to update these forward-looking statements in the event that management's beliefs, estimates or opinions, or other factors, should change.
SOURCE NetCents Technology Inc.
For further information: please visit the corporate website at http://www.netcents.biz or contact Robert Meister, Capital Markets at Ph: 604.676.5248 or email: Robert.meister@net-cents.com.
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Take part in the show with ‘Dr. Amnesia Trance’s Hypnotic Show’ – The Register-Guard
Posted: at 3:21 am
Dr. Amnesia Trances Hypnotic Show
Friday, July 21 through Sunday
Cottage Theatre
Theaters fourth wall will break during an interactive performance featuring young actors from the Cottage Theatres summer Melodrama Camp. Dr. Amnesia Trances Hypnotic Show invites audiences of all ages to engage in the performance with callbacks and an opening sing-along.
The show plays at 7 p.m. Friday and Saturday with a matinee at 2:30 p.m. Sunday. Tickets are $7 (cottage theatre.org/tickets or 541-942-8001). The Cottage Grove Theatre is at 700 Village Drive in Cottage Grove.
Love Letters
Friday, July 21 through July 30
Class Act Theatre
A tale of distant love and the power of the written word comes to the Class Act Theatre in Florence.
Love Letters, a play by A.R. Gurney, was a finalist for the Pulitzer Prize for Drama. The production is in honor of Gurney, who died June 13. David Lauria plays Andrew Makepeace Ladd III and Rosemary Lauria plays Melissa Gardner, childhood friends who begin a lifelong correspondence with birthday party thank-you notes and summer camp postcards. As their life journeys take them on divergent paths, they remain close through written letters, which come to encompass the love that they share.
Paula Lindekugel-Willis directed the show.
It runs Friday through July 30, with 7 p.m. Friday and Saturday shows and 2 p.m. Sunday matinees. Tickets are $18 (catproductions.org or 541-991-3773).
The Class Act Theatre is at 509 Kingwood St. in Florence.
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Take part in the show with 'Dr. Amnesia Trance's Hypnotic Show' - The Register-Guard
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Competition: Watch The Jetwalls In Cyberpunk Motorcycle Game Qbike – VRFocus
Posted: at 3:20 am
When people are first introduced to the concept of virtual reality (VR) many tend to think of something theyve seen in TV or in a movie, or those that have had experience of it in previous generations of the technology might think it is purely that. For tha majority though its the memory of the fiction that stays with them more and is called to compare with VR of today. It can be both a help and a hiderance, something weve discussed onVRFocus on a couple of occasions.
When it comes to those visions of what VR is like one of the biggest is, of course, TRON, Disneys film about a computer programmer being zapped into a computer and being forced to play games for his very life. A franchise that has inspired many of todays videogame developers. So, it would be safe to say that Qbike:Cyberpunk Motorcycles is rather TRON influenced, baring in mind that the game is a VR representation of the classic lightcycles game, more specifically a more fully realised version in terms of design and play of that seen in TRON Legacy. With multiple levels of play and the bikesjetwalls even being effective in the air.
Weve teamed up with developers, GexagonVR, to offer you the chance to win one of four codes for the videogame which is currently in Early Access on Steam. Qbike will be offering support of Oculus Rift and HTC Vive
You haveapproximately a week in order to enter as youve until the turn of Thursday, 27th July2017 in the UK. The competition is open to everyone, though please note youll need to have an Steam account in order to claim the code. To enter all you have to do to is use the app below and be either a follower of VRFocus on Twitter, be a subscriber to ourYouTube channel or visit our Facebook or Google+ pages. Thats it. You get an entry for any of those so make sure you check everything out.
Win Qbike on Vive/Rift (Steam Early Access)
Well let winners know as soon as possible after the competition ends. Good luck!
Long time Social & Community Manager and occasional writer of words, looks pretty dashing with technology strapped to his head. As well as keeping the team's social media channels ticking over, Kevin's also a feature writer for VRFocus best known for the Tuesday afternoon "VR vs." opinion piece. Among many other roles Kevin E is also our (unofficial) Deputy Editor.
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Competition: Watch The Jetwalls In Cyberpunk Motorcycle Game Qbike - VRFocus
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Racers Prepare For Solar Car Competition At TMS CBS Dallas … – CBS DFW
Posted: at 3:20 am
Racers Prepare For Solar Car Competition At TMS
One of the largest solar car races on the planet is happening this week in North Texas. Check out some of the racers who will be competing. They come from 36 high schools across nearly a dozen states.
Effort Underway To Change Name Of Busy Road In DallasA new proposal within the City of Dallas could change the name of Plano Road to North Lake Highlands Drive.
John Wayne Gacy Victim Identified Four Decades LaterThe Cook County Sheriffs office in Illinois announced on Wednesday the DNA match is that of 16-year old James Jimmie Haakenson.
Top Cop Driven By Personal Tragedy To Fight CrimeChief Renee Hall's father was murdered when she was 6 months old.
Senator John McCain Diagnosed With Brain CancerThe discovery came after he had a blood clot removed above his left eye.
North Texas Neighborhood Is A Speeding 'No Man's Land'Alleged speeding in a Godley neighborhood is so severe, some parents won't let the kids play outside.
Frisco ISD In Urgent Need Of Bus DriversThe school district is looking to add 30 bus drivers as soon as possible.
Fire And Explosions At Lake Texoma MarinaEmergency crews are at Lake Texoma responding to a fire and several explosions at Highport Marina in Pottsboro.
Oak Cliff Drive-By Shooting Turns Into Gun BattleA man and a woman were wounded after rounds of gunfirewere exchanged outside a convenience store in east Oak Cliff.
North Texas Traffic Stop Ends With Dispatcher ProposalThe site of flashing red and blue lights in the rearview mirror can startle just about anyone.But there was a big surprise waiting for one North Texas woman who was literally in tears after she was pulled over for speeding and then informed there were warrants involved.
New Details In Death Of Dallas 4-Year-Old, Mother's Boyfriend ChargedHorrific new details are emerging in the death of a 4-year-old Dallas boy and the subsequent arrest of a 27-year-old man.
Dallas ISD Push Back Against Charter Schools13 percent of DISD's expected enrollment attends area public charter schools
DPD Suspends Elliott Investigation Over Lack Of Witness CooperationDallas Police have suspended into an incident that allegedly involved Cowboys running back Ezekiel Elliott
Racers Prepare For Solar Car Competition At TMSOne of the largest solar car races on the planet is happening this week in North Texas. Check out some of the racers who will be competing. They come from 36 high schools across nearly a dozen states.
Heavy Rain, Fast-Moving Water Brings Garbage To White Rock Lake ShoresThe lake is surrounded by creeks that feed into the water that bring runoff from as far away as Frisco during a big downpour.
'Seed Library' Giving North Texans Healthy Eating Nudge: Check It Out!Some Dallas Main Library staffers decided to give patrons a little push, by providing free seeds along with information and resources.
Transgender Woman Trolls Abbott With PhotographA transgender woman took her 'bathroom bill' protest directly to Gov. Greg Abbott, and he may not have even noticed.
Racers Prepare For Solar Car Competition At TMSOne of the largest solar car races on the planet is happening this week in North Texas. Check out some of the racers who will be competing. They come from 36 high schools across nearly a dozen states.
Behind The Scenes: Fort Worth Battling Cyber AttacksA behind the scenes look at how the city of Fort Worth fights off cyber attacks.
Transgender Woman Trolls Abbott With PhotographA transgender woman took her 'bathroom bill' protest directly to Gov. Greg Abbott, and he may not have even noticed.
Racers Prepare For Solar Car Competition At TMSOne of the largest solar car races on the planet is happening this week in North Texas. Check out some of the racers who will be competing. They come from 36 high schools across nearly a dozen states.
Soundwave Tattoos Turn Skin Art Into AudioA tattoo innovation is bringing a new way to preserve memories. Soundwave tattoos combine ink and technology, turning skin art into audio that can be played with an app.
Triple-Digit Heat On The WayA typical stifling North Texas summer is here!
Effort Underway To Change Name Of Busy Road In DallasA new proposal within the City of Dallas could change the name of Plano Road to North Lake Highlands Drive.
John Wayne Gacy Victim Identified Four Decades LaterThe Cook County Sheriffs office in Illinois announced on Wednesday the DNA match is that of 16-year old James Jimmie Haakenson.
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BRAIN center gathers to ponder future, direction – Arizona State University
Posted: at 3:19 am
July 19, 2017
For all its resiliency and creativity, the human brain is equally fragile and prone to disease. Millions around the world are affected by neurological and neurodegenerative diseases. In fact, a World Health Organization study found eight out of 10 disorders in the three highest disability classes are linked to neurological problems, a figure likely to increase, as the global elderly population is expected to double by 2050.
In response to this growing need, a new collaboration between Arizona State University, the University of Houston and industry members formed to develop and test new neurotechnologies. Above: From left to right, Professors Jose L. Contreras-Vidal and Marco Santello pose for a photo with Deans Joseph W. Tedesco and Kyle Squires, of the University of Houston's Cullen College of Engineering and ASU's Ira A. Fulton Schools of Engineering, respectively, at Old Main on the Tempe campus, June 29. Santello and Contreras-Vidal lead the ASU and UH sites for the new National Science Foundation-funded Building Reliable Advancements in Neurotechnology, or BRAIN, an IndustryUniversity Cooperative Research Center. Photo by Jessica Hochreiter/ASU Download Full Image
Building Reliable Advancements in Neurotechnology, or BRAIN, is an IndustryUniversity Cooperative Research Center dedicated to bringing new neurotechnologies and treatments to market. The center was officially funded earlier this year with a $1.5 million grant from the National Science Foundation, and has already attracted nine industry partners.
BRAIN held its first industry advisory board meeting June 2930 on ASUs Tempe campus, bringing together stakeholders to begin charting the course of the collaboration.
Neurodegenerative diseases are one of the biggest challenges society faces today, said Professor Marco Santello at the outset of the meeting. An aim of the center is to not only develop new devices and strategies in the realm of neurotechnology, but validate existing ones as well.
Santello and Professor Jose L. Contreras-Vidal, directors of the respective ASU and UH BRAIN sites, will lead the center, which includes more than 40 faculty members from ASUs Ira A. Fulton Schools of Engineering and UHs Cullen College of Engineering.
The pair defined the centers five main research areas as neurological clinical research, mobility assessment and clinical intervention, invasive neurotechnology, noninvasive neurotechnology and neurorehabilitation technology.
Santello, who also serves as the director of the School of Biological and Health Systems Engineering, said BRAINs areas of interest are intentionally broad as to fully investigate all potential solutions, approaches, and outcomes related to neurotechnology.
Contreras-Vidal, who also leads UHs Laboratory for Non-invasive Brain-Machine Interface Systems, noted the unique faculty resources that UH and ASU bring together, whose research expertise encompasses neuroscience, invasive and noninvasive interfaces and neuromodulation, neuroimaging, rehabilitation technologies, big data and bioinformatics as well as regulatory science and law and neuroethics.
Though a stable of researchers firmly rooted in neurology, data, device development and clinical trials are essential to BRAINs success, equally important is the inclusion of regulatory law experts. To this end, Contreras-Vidal is leading a Research Collaborative Agreement between UH and the Food and Drug Administration.
Brain activity measurements, such as scalp electroencephalography, have both diagnostic value in and of themselves, and also value as objective endpoints for measuring the efficacy of other medical devices. However, despite their growing importance, very little is known about the constancy and variability of these measurements in real complex settings in healthy individuals and in the patient population. Nevertheless, the efficacy and safety of EEG-based diagnostics and therapeutics depend on such scientific understanding, Contreras-Vidal said. Thus, understanding of the population distribution of EEG-based biometrics is regulatory science that contributes to personalized medicine and to the development of better biomedical devices.
Professor Barbara Evans of UH, whose background includes engineering, earth science and law, will serve as a resource for regulatory processes, issues and strategy, noting its sometimes necessary to think five or 10 years ahead.
This type of work is going to take careful thought about how to address the FDA, and work out regulatory solutions, said Evans, who is also the director of the Center on Biotechnology and Law at UH. The burden of neurocognitive diseases is a pressing problem. While there are pharmaceutical solutions which have promise, there is even greater promise in terms of the research at BRAIN and I believe we have to attack these diseases on every front. The main thing I hope to do is help translate wonderful technology to market and help people.
The nine industry partners include companies such as Medtronic, the CORE Institute, Indus Instruments and Brain Vision LLC, as well as medical institutions such as the Phoenix Childrens Hospital and The Institute for Rehabilitation and Research Memorial Hermann Hospital.
Eric Maas, a Medtronic representative, said his company was drawn to the immense talent pool contained within BRAIN.
This partnership not only benefits Medtronic, but the world, Maas said. Big companies like ours like to go after big problems, but a center like this opens up paths to solve smaller, sometimes overlooked illnesses that deserve attention.
For Dr. David Adelson, director of the Barrow Neurological Institute and chief of pediatric neurosurgery at Phoenix Childrens Hospital, BRAIN has been a long time coming. Adelson has long since been an advocate for bringing cutting-edge research to clinical care, pushing for a center like BRAIN for some time.
So much of medicine is focused on adults and not children, and so much of is applicable to pediatric care, said Adelson, noting that traumatic brain injury is the leading cause of disability and death in children and adolescents in the U.S.
United with invested industry partners, the multifaceted, transdisciplinary research approach of ASU and UH caught the interest of the National Science Foundation as a way to address the big picture challenges of brain research.
The technical expertise of both ASU and UH goes without saying, but both universities did well in bringing together industry members to get this center off the ground, said Dmitri Perkins, director of the NSFs IUCRC program. Brain research is in general an area of great national interest. The NSF looks for centers with potential to deliver great impact in their areas of study as well as the possibility to work with other IUCRCs, universities and industries, and we see that here.
VisitBRAIN onlinefor more information about the center, or contactSantelloandContreras-Vidalto discuss partnership opportunities.
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BRAIN center gathers to ponder future, direction - Arizona State University
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Vertex (VRTX) Triple Combination CF Studies Data Positive – Zacks.com
Posted: at 3:19 am
Vertex Pharmaceuticals Incorporated (VRTX - Free Report) announced data from three studies wherein three different triple combination regimens were evaluated for the treatment of cystic fibrosis (CF). These led to pronounced improvements in lung function. Shares of the company surged more than 25% in after-hours trading following the announcement of the positive data.
So far this year, Vertexs shares have significantly outperformed the Zacks classified Medical-Biomed/Genetics industry. The stock has gained 79.4% compared with an increase of 8.8% registered by the industry.
Two phase II studies evaluated VX-152 (200mg q12h) or VX-440 (600mg q12h) and a phase I study evaluated VX-659, all three in combination with Kalydeco and tezacaftor for the treatment of CF patients with one F508del mutation and one minimal function mutation (F508del/Min). The primary endpoint of these studies was improvement in lung function measured by percent predicted forced expiratory volume in one second (ppFEV1). It measures the volume of air one can exhale in one second.
All the studies met their primary endpoints. The study evaluating VX-152 showed a mean absolute improvement of 9.7% points in ppFEV1 from baseline through two weeks versus placebo. The study on VX-440 showed an absolute change of 12% points in ppFEV1 from baseline to the average of the week 4 measurements versus placebo. The VX-659 regimen achieved a mean improvement of 9.6% points from baseline compared to placebo.
The data demonstrated the potential of the regimens to treat the underlying cause of CF in patients with severe and difficult-to-treat type of the disease rather than treating the symptoms. Also, the three different regimens were well tolerated in patients and most of the adverse events were mild to moderate in severity.
The company is also evaluating VX-152 or VX-440 in patients with two copies of the F508del mutation who are already receiving tezacaftor and Kalydeco combination. The initial data showed improvements in mean absolute ppFEV1 of 7.3% and 9.5% points.
Vertex fourth next-generation corrector under development is VX-445. A phase II triple combination (in combination with Kalydeco and tezacaftor) study on VX-445 is ongoing whereas the company expects to initiate phase II study on VX-659 early next month. Data from these studies are expected in early 2018. Thereafter, upon discussion with regulatory agencies, Vertex will initiate pivotal studies on one or more of these triple combination regimens in the first half of 2018.
We remind investors that Vertex remains focused on CF treatments. The company has two CF drugs Kalydeco & Orkambi in the market. Orkambi and Kalydeco together are approved to treat approximately 40% of the 75,000 CF patients in North America, Europe and Australia. They generated revenues of $481 million in the first quarter of 2017 together, which was 22% higher than the year-ago period.
On successful completion of these triple combination studies and subsequent approval, CF patients with minimal function mutations will also be eligible for treatment by Vertexs portfolio of CF drugs. This should significantly boost Vertexs sales.
Zacks Rank and Key Picks
Vertex currently carries a Zacks Rank #1 (Strong Buy).
Some other top-ranked stocks in the health care sector are Enzo Biochem, Inc. (ENZ - Free Report) , Exelixis, Inc. (EXEL - Free Report) and Corcept Therapeutics Incorporated (CORT - Free Report) . All the three stocks sport a Zacks Rank #1. You can see the complete list of todays Zacks #1 Rank stocks here.
Enzo Biochems loss estimates have narrowed from 12 cents to 7 cents for 2017 and from 11 cents to 3 cents for 2018 over the last 60 days. The company came up with positive earnings surprise in the last four quarters, with an average beat of 55.83%. Its share price is up 64.8% so far this year.
Exelixis earnings estimates remained stable at 17 cents for 2017 and moved up from 53 cents to 55 cents for 2018, over the last 30 days. The company delivered positive earnings surprises in the last four quarters, with an average beat of 512.11%. The stock is up 75.4% so far this year.
Corcepts earnings remained stable at 26 cents for 2017 and moved up from 51 cents to 52 cents for 2018, over the last 60 days. The company delivered positive earnings surprises in three of the last four quarters, with an average beat of 53.33%. The stock is up 70.9% so far this year.
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Vertex (VRTX) Triple Combination CF Studies Data Positive - Zacks.com
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Biotech Stock Roundup: Vertex Boosted by CF Data, FDA Nod for Gilead, Puma Drugs – Zacks.com
Posted: at 3:19 am
Key highlights this week include impressive data from Vertexs (VRTX - Free Report) cystic fibrosis (CF) pipeline while companies like Gilead (GILD - Free Report) and Puma (PBYI - Free Report) got FDA approval for their hepatitis C virus (HCV) and breast cancer treatments, respectively.
Recap of the Weeks Most Important Stories
Vertex CF Data Impresses: Vertex got a major boost with positive data on three different triple combination regimens in people with cystic fibrosis (CF) who have one F508del mutation and one minimal function mutation (F508del/Min). These are the first data to show the potential to treat the underlying cause of CF in these patients, who have a severe and difficult-to-treat type of the disease. The company is looking to start a pivotal program in the first half of 2018. Vertexs shares were up significantly in pre-market trading.
CRL for Amgen/UCB Osteoporosis Drug: Amgen (AMGN - Free Report) and partner UCB got a Complete Response Letter (CRL) from the FDA for Evenity (romosozumab), their investigational treatment for postmenopausal women with osteoporosis. However, the CRL doesnt come as a surprise considering the emergence of a new safety signal in a late-stage study (ARCH). Although Evenity met both the primary endpoints and the key secondary endpoint in the study, the companies said that an imbalance in positively adjudicated cardiovascular serious adverse events was observed.
The FDA has asked the companies to include data from the ARCH study in the resubmission as well as data from the BRIDGE study in men with osteoporosis (Read more: Amgen Gets CRL for Osteoporosis Drug Evenity's BLA). Amgen is a Zacks Rank #3 (Hold) stock -- you can see the complete list of todays Zacks #1 Rank (Strong Buy) stocks here.
FDA Nod for Gilead HCV Drug: Gilead has added another drug to its hepatitis C virus (HCV) portfolio with the FDA granting approval to Vosevi, a single-tablet regimen for the re-treatment of adults with chronic HCV. Vosevi provides physicians with a new therapeutic option for their hardest-to-treat patients. However, Vosevi comes with a boxed warning regarding the risk of hepatitis B virus (HBV) reactivation in HCV/HBV co-infected patients -- this could limit uptake.
Gileads HCV franchise, which was a major revenue generator, is under considerable strain due to new competition and pricing pressure. The company has underperformed the Zacks-categorized Medical-Biomedical/Genetics industry so far in 2017 with shares gaining 0.1% while the industry is up 8.9%.
Puma Up on FDA Approval of Nerlynx: Puma gained FDA approval for its breast cancer treatment, Nerlynx (neratinib), which has blockbuster potential. Nerlynx, the first approved drug in Pumas portfolio, is indicated for the extended adjuvant treatment of early-stage, HER2+ breast cancer, an aggressive type of tumor. This means that Nerlynx can be taken after an initial treatment so that the risk of the cancer coming back can be reduced further. Nerlynxs approval was in line with expectations considering a favorable advisory panel vote earlier this year. Pumas shares were up 8.5% on the news. Year-to-date (YTD), Pumas shares are up a whopping 204.4%.
Sarepta-BioMarin Settle Patent Dispute: Sarepta (SRPT - Free Report) and BioMarin settled their patent dispute regarding the use of Sareptas Exondys 51 and all future exon-skipping products for the treatment of Duchenne muscular dystrophy (DMD). The companies signed a licensing agreement providing Sarepta with global exclusive rights to BioMarins DMD patent estate for Exondys 51 and all future exon-skipping products. BioMarin has the option to convert the license to a co-exclusive right if it decides to proceed with an exon-skipping therapy for DMD. Terms of the deal include a one-time $35 million payment from Sarepta as well as certain milestone-based payments and royalties. Sareptas shares were down 3%.
Performance
Medical - Biomedical and Genetics Industry 5YR % Return
The NASDAQ Biotechnology Index was up 1.1% over the last five trading sessions. Among major biotech stocks, Biogen (BIIB - Free Report) was up almost 4%. Over the last six months, Vertex was up 60.2% while Alexion (ALXN - Free Report) was down 6.7% (See the last biotech stock roundup here: Arena Shoots Up on Study Data, CELG Inks Immuno-Oncology Deal).
What's Next in the Biotech World?
Watch out for earnings reports from companies like Biogen and Sarepta.
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Zacks has just released a Special Report on the booming investment opportunities of legal marijuana.
Ignited by new referendums and legislation, this industry is expected to blast from an already robust $6.7 billion to $20.2 billion in 2021. Early investors stand to make a killing, but you have to be ready to act and know just where to look. See the pot trades we're targeting>>
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Biotech Stock Roundup: Vertex Boosted by CF Data, FDA Nod for Gilead, Puma Drugs - Zacks.com
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What the loss of lvaro Morata means for Real Madrid CF – isportsweb.com (blog)
Posted: at 3:19 am
Real Madrid is having quite a busy off-season. The team has agreed to terms with English club, Chelsea, for the transfer of lvaro Morata. The transfer fee is believed to be for 85 million. In a brief statement, the Blues have said: Chelsea Football Club and Real Madrid have agreed terms for the transfer of Alvaro Morata to Stamford Bridge. The move is now subject to him agreeing personal terms and passing a medical.
Agreement Chelsea-Real Madrid for 85 M + 9 M season, 5 years contract for #Morata @SkySport #Transfers #CFC pic.twitter.com/yYK04WPe6Y
Angelo Mangiante (@angelomangiante) July 19, 2017
The signing reportedly comes at the request of Antonio Conte, who had attempted to sign the Spanish international for Chelsea last summer. The Blues are looking for a new striker to replace Diego Costa who is reportedly leaving the club this summer.
Real Madrid have also confirmed the move, stating: Real Madrid C.F. and Chelsea F.C. have reached an agreement regarding the transfer of lvaro Morata, subject to the player completing his medical. The club wishes to express its thanks for the dedication, professionalism and exemplary conduct displayed by the player over the years, spanning his time in our academy right through to his spell as a member of the first-team squad.
Morata was first associated with the Spanish club in 2008 when he joined the Real Madrid youth team. He made his debut with the first team two years later in 2010 appearing in 52 games and scoring 11 goals. Most notably in 2013, Morata played the complete 90 minutes in El Clsico against FC Barcelona and provided the assist to Karim Benzema for the games opening goal. He transferred to Juventus for 20 million in 2014, successfully winning the domestic double of Serie A and Coppa Italia. However, Real Madrid exercised their buy-back clause to bring back Morata from Juventus for 30 million in June of 2016.
Earlier this year, Morata admitted in an interview with The Guardian that he expresses constant gratitude towards Conte. Morata stated: Conte is the manager who most bet on me, without even ever having had me in his team. Im very conscious of that: he bet on me for Juventus but left before I arrived; then he wanted me at Chelsea come what may. He knows me better than I could imagine, Im sure. And thats important, it motivates you to work hard, train well.
Morata concluded his praise, saying: I feel indebted to him because hes the coach that most trusted in me, most wanted me, who made me feel I could perform at the highest level.
With the transfer, Real Madrid inevitably loses depth at the striker position. Morata served as an excellent substitute option for Karim Benzema. Real Madrid will likely rely more on Gareth Bale to be a viable option in late-game minutes. Bale has often come on as a substitute later in games and has proven that he can provide a spark when the team needs it the most. The team will also turn to budding star Francisco Romn Alarcn Surez, otherwise known as Isco. The wing position opposite Cristiano Ronaldo has always been a relatively weaker point in the Madrid offense. Isco will be asked to service crosses into the box for both Ronaldo and Benzema and he has shown in the past that he is capable of such a task.
The departure of Morata will also open the door for young striker Nikolaos Vergos. The 21-year-old has spent his time on the third string but could potentially earn a spot with the second team. Vergos is a pure finisher with excellent technique. He is known for his ability to head the ball out of the air and create opportunities for himself. He also provides versatility given the fact that he can move to center-forward with no drop in productivity.
Real Madrid are also planning a bid of their own. The team is reportedly ready to make an offer to finally seal the transfer of Monaco striker Kylian Mbappe. The 18-year-old scored 15 goals and recorded eight assists last season.Mbappes price tag is rumored to be around 120 million with Real Madrid now ready to step up to the bid.
Student at George Mason University. Avid sports enthusiast covering the Carolina Panthers, Washington Wizards, and Real Madrid C.F.
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What the loss of lvaro Morata means for Real Madrid CF - isportsweb.com (blog)
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