Monthly Archives: July 2017

How To Value Bitcoin – Seeking Alpha

Posted: July 22, 2017 at 7:51 am

Bitcoin (OTCQX:GBTC) (Pending:COIN) (OTCPK:BITCF) (OTCPK:BTSC) and other cryptocurrencies have skyrocketed in value recently:

And I see a lot of misconceptions. Since cryptocurrencies are very hyped up currently, most people investing in these things are not very sophisticated. So where to start? Valuing a currency is difficult. I will start by laying out the different types of asset classes and how I think about valuing them. A currency has several characteristics:

Now as far as cryptocurrency is concerned, the same rules apply. I am going to assume the reader knows the technical side of bitcoin, and I will only focus on the economic aspects.

So how do we value a cryptocurrency? This seems problematic since a large amount of speculators have poured in a ton of money with the only purpose of selling their coins later for a profit. Which would basically make this a pyramid scheme if no legitimate buyers come in with the goal of actually using cryptocurrencies for transactions.

First let's define what value means. We ran into a little problem right away here since the first bullet point of this article already states that currency has no intrinsic value. I would say something has value if it helps filling our needs and wants. Generally this is expressed in monetary terms. Obviously there are things that have intangible value like friendship, etc. So let's just focus on assets that are actually transacted on a market for money. I can see three different types of asset classes:

The most common way to value a currency is in terms of another currency. So the Japanese Yen would be valued in terms of USD or EUR for example. A more convoluted way would be to look at total goods and services being transacted in that currency or value it in terms of bags of rice or grain. But if you use bags of rice to measure a currency, then those bags of rice would actually turn into a currency as well. Obviously there is a grey area between the currency asset class and the commodity asset class. How to proceed?

The main difference between a currency vs. the other two asset classes is that the supply demand dynamic is very different. For example, if I go on vacation to Mexico and need to buy pesos, I don't look at what the fair value is. I just look at the general exchange rate and try to buy as close to that as possible. This is the same for cryptocurrencies. This is very different than when I buy a house or a barrel of oil. There is a certain price cap at which I would never be a buyer with those asset classes. This is not really the case for currencies (with some extreme exceptions of course). It makes no difference to me if bitcoin is at $20, $200 or $2,000 if I want to exchange it for a bag of weed on one of the dark web marketplaces.

So in order to value a currency, we have to look at what fundamental factors other than speculation cause the supply and demand to be in equilibrium. And how much money from other currencies needs to flow in to get supply and demand in equilibrium determines its fair value relative to those other currencies. This is very important to keep in mind. Since we don't need to know what drives supply and demand to value a house or a barrel of oil. We just need to figure out how much rent it could produce or what the marginal cost is and at what price these two assets can be reasonably used. If oil goes to $1,500 per barrel (with other asset values staying constant), I would not buy it to fill my gas tank, and would probably switch to an electric car. And I would not speculate on it since demand will likely fall of a cliff if oil gets this expensive, cratering the price. And I would probably start buying canned food since the survival of civilization depends on low oil prices.

Or as Warren Buffett likes to say: Mr. Market is there to serve you not to guide you when valuing those assets. But with currencies you want to know if people buy it to use it (in that case, it has value) or just buy it to speculate (in that case, it would look more like a pyramid scheme).

Due to the lack of sensitivity for price paid for another currency and the large % of speculative money compared to money that flows in only to buy goods using bitcoin, the total market cap is very unreliable to see how many people use bitcoin for transactions. Why is that? Allow me to give an extreme and unlikely hypothetical scenario to get this point across.

Let's say that in a given day there is one person using bitcoin for practical reasons who wants to make a number of transactions with a total value of $1 million. So he goes to CoinDesk to exchange a total amount of $1 million. Let's also assume that all the miners have been hoarding their bitcoins and there are only ten bitcoins whose owner is willing to sell. And let's also say that there are no other buyers or sellers in this day.

And they are sold all in one chunk to make it easy.

Another very other important assumption in this hypothetical scenario, no price is high enough to create more sellers (let's assume willing sellers are all on vacation at the time). So no matter how high the bitcoin value goes, the number of bitcoins available stay at 10 in this day. So now this $1 million is fighting for 10 bitcoins. And in order to fill the order, the price would have to shoot up to $100,000 per bitcoin.

So now the market cap is $100,000 * 16.5 million bitcoins, right? That would be a market cap of $1.65 trillion. But there was only an inflow of $1 million, which is a fraction of $1.65 trillion. So obviously there is a problem here. If those other speculators would wake up the next day, there would need to be an inflow of $1.65 trillion if they wanted to actually cash in.

Or you might say they simply use bitcoin to make transactions and cash in that way. But there is one little problem with that which I will explain below.

Consider bitcoin's main value currently. Since it is not that widely used (especially by B2B companies), it is very volatile and salaries and suppliers are generally not paid in bitcoin, and merchants need to sell their bitcoin after making a transaction. So usually the time between when a buyer buys bitcoin and when the merchant sells it to pay his bills and wages is pretty short. The main way it is used (other than speculating) is that most hold their bitcoins for a short amount of time to make transactions that are difficult or not possible with regular currency. This is very important to keep in mind.

Let's consider another hypothetical scenario to show why this matters. In this world, bitcoin is not used for speculating at all. This is basically another extreme since now all bitcoins would be available to buy for the above user who wants to buy $1 million worth of goods with bitcoin. The hype has passed. And coins are only used for making transactions (mostly on dark web marketplaces).

The average holding period is one week given the limited number of vendors willing to accept them. So there is exactly one week between a person buying coins to make a transaction and the merchant who accepts this transaction selling them again for fiat currency.

Now there are 21 million coins in existence. And nobody hoards them to speculate. All the holders are immediately willing to sell them for any price (economics is easy with all those assumptions!).

To make this easier, let's say that there was a break and this is the first week bitcoin is being used again (this is unrealistic but makes it more intuitive to understand). So no sellers from the previous week.

In week one, $10 million flows into the bitcoin economy and every bitcoin holder sells their coins. Bitcoin value would edge up until it reaches about $0.50 per coin. And the total market cap of bitcoin would now only be ~$10 million. Very different from the above $1.65 trillion.

How would price discovery work? Let's say that they are bought each hour in fixed chunks of $10 million divided by 168 (number of hours in one week), or blocks of $60,000 per hour. So the first transaction would be $60,000 bidding against 21 million coins, and since no seller is anchored at any price, they will be sold for a very low price.

This process will be messy at first. If they are sold for a lower price than $0.50, there will be shortage later on. And there would be a need for arbitrage. So the price might be only $0.15 at day 4, but on day 7, the price might be $15 if the last blocks of fiat currency bid against a much smaller amount of bitcoins. It would take some time for the market to learn that weekly volume is about $10 million. So arbitrageurs might hold coins at any time to smoothen out demand. So possibly the fair value in this case would be a bit higher than $0.50 since at any time a % of coins are taken out of circulation by traders.

So why is length of holding period important? Well, the amount of coins available would slowly decrease while the market is discovering demand. In the second week, there would be $10 million of coins gradually being sold by merchants, and they would again be bought by buyers of goods (assuming that every week $10 million of goods are being transacted).

But if merchants would hold on for two weeks, then the market cap of bitcoin would double. Since there are no sellers for two weeks now. So $20 million would bid at 21 million coins, and market value of one bitcoin would stabilize at around $1 when the merchants' coins flood back in.

So what can we conclude from this? If on average bitcoins would take longer and longer to be sold back for fiat currency, it's value would go up. Even if total transaction volume stays the same. This would only happen if bitcoin would be very widely accepted. And there is a bit of a problem with that. Bitcoin and other cryptocurrencies are very useful to use in markets that sell illegal goods or services or for hackers to get their ransom from locking up computers. The illegal drug market has exploded in size. In 2013, the Silk Road was estimated to generate about $100 million in sales annually. There are now several marketplaces that have replaced Silk Road that are each larger in size. The main advantage here is that due to the ease of leaving good and bad reviews, it is much easier to buy quality drugs. A lot of vendors even offer customer service!

But for completely legal markets, bitcoin or other cryptocurrencies seem very impractical. I would need to pay more transaction costs (both for buying coins and making the transaction), there is more volatility, and if I lose my password, there is no central authority to get a new password! This last point is especially annoying since this has happened twice to me in the past 10 years. If I used bitcoin, I would have lost several thousand USD. It is very telling that in Venezuela and Zimbabwe they now use USD instead of cryptocurrency. Bitcoin caught on very, very quickly on dark web marketplaces, yet there seems to be little interest in it in countries with hyperinflated currencies. Even if they are used in countries like Venezuela, they are not used for transactions due to the high transaction costs currently. But are used instead to evade capital controls.

That said, there does seem to be a use for remittances, underage gambling, and illegal drugs. If we assume that governments won't successfully crack down on this, this could be a large market.

And, of course, there are a lot of people arguing that fiat currencies inflate over time. And that deflation is the main selling point of cryptocurrencies. But here is a problem since if there is large deflation, it encourages speculation, and if there is a lot of speculation, the currency will be very volatile. This will discourage people to use it (or hold it for long if they use it).

And with regular currencies, you can buy investments to protect against inflation, so this should really not be an issue. For example, the S&P 500 generated 7% annual returns after inflation in the past 100 years. So, yes, you would have lost a lot of money if you held US dollars in your bank account, but you would be rich if you had put it in stocks instead. This is not yet an option for cryptocurrencies.

The current market cap of bitcoin is about $44 billion. And the current market cap of all the cryptocurrencies is close to a $100 billion. Now, I know for a fact that those other cryptocurrencies are rarely used for actually transacting goods and services since most vendors do not accept them. And most people who buy cryptocurrency don't seem to use it. They buy it to speculate. Since bitcoin has a clear network effect advantage here, I will focus on that.

What is total addressable market (TAM) of bitcoin? The illegal drug market is about $400 billion a year and the total online gambling market is about $40 billion a year. And the total remittance market is about $500 billion. So a TAM of $940 billion. But it is obviously not realistic they take 100% market share. For one, it would be very easy to detect $400 billion in illegal drugs going through the postal system. And financial institutions are not just going to sit on their ass and let some Internet currency take away their billion-dollar businesses. But let's say Bitcoin capture 50% market share here. Or about $470 billion.

Now, here is why I bored you with the above hypothetical examples. The fair value of bitcoin will not be $470 billion. Because holding period is going to be very important here. Often people do not hold bitcoin for a long time; they will use it as a transmission mechanism. For example, for remittance, they buy $500 worth of bitcoin, and then send it to their relatives who then exchange it for an equivalent of $500 in their local currency. So holding period is often short. Same with gambling, the gambling platform would likely convert it to fiat currency right away after the deposit due to its volatility. But let's be generous here and say the average holding period is a month. That would imply the TAM of bitcoin would be about $470 billion/12 months = $39 billion.

If the holding period is only a day, fair value would only be $1.3 billion.

This would imply that cryptocurrencies are in bubble territory. The only way there is significant upside is if cryptocurrencies replace fiat currency in a significant way. But as we have seen with Venezuela and Zimbabwe, even if there is hyperinflation in a country, its inhabitants can always use another more stable fiat currency. Which is easier.

Bitcoin's value depends on it being decentralized. A way to destabilize bitcoin would be to do a 51% attack. This would mean that you need more than the total amount of mining rigs (mostly ASIC chips) that currently mine bitcoin. Generally bitcoin fanatics don't think this will happen. But this will change the moment bitcoin would get seriously big. For example, if 20% of the US economy is dependent on bitcoin, Russia might be willing to shell out $10-15 billion to destabilize it. Which is a small amount given that Russia is a $1 trillion + economy.

What would it cost to do a 51% attack currently? The Hashrate is about 6 million TH/s currently. Hashrate means total amount of computing power each second that is mining bitcoin currently. A 14 TH/s mining rig costs $3,000. So hardware would cost about $1.2 billion (assuming no bulk discount). Now there is real estate, electricity and labor costs as well. So let's be very conservative and double that to $2.4 billion. That is pocket change for countries like China or Russia to destabilize a foreign government. Russia's annual government revenue is $200 billion. So this number would have to grow by 20-30x before it would become prohibitively expensive to destabilize it.

There is kind of a problem here if transaction volume does not reach a critical mass before most of the bitcoins are mined out. When current mining rigs expire and transaction volume is not significantly higher, there will probably be a drop-off in the number of mining rigs and this will increase the risk of a 51% attack. Or miners will have to raise transaction costs, which will discourage people to use bitcoin. Currently transaction costs are quite high.

Based on the above, I would stay far away from bitcoin and other cryptocurrencies. There are simply too many obstacles, and it seems the current valuation is too high. I would probably enter if bitcoin was valued below $50 a coin. Which might happen soon given that most coins are hoarded currently. And all those speculators might get impatient and want to sell. And if that happens and there is no significant legitimate demand for non-investment purposes, the price could easily get below $50 again.

Disclosure: I/we have no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours.

I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.

Editor's Note: This article covers one or more stocks trading at less than $1 per share and/or with less than a $100 million market cap. Please be aware of the risks associated with these stocks.

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Google Street View’s latest destination: The International Space Station – Washington Post

Posted: at 7:50 am

Youve used Google Street View to check out a new apartment, map traffic before you hit the road and search for haunting slices of the everyday world.

Now, the comprehensive terrestrial mapping system has gone extraterrestrial, allowing users to peer inside the International Space Stationfrom their computer 248 miles below with 360-degree, panoramic views.

The Street View imagery was captured by Thomas Pesquet, an astronaut with the European Space Agency, who spent six months aboard the ISS before returning to earth in June.

Google Street View, which is featured in Google Maps and Google World, was launched in 2007 and quickly expanded locations around the globe, including places as remote as Mount Everest base campand as offbeat as Scotlands Loch Ness. The vast majority of Street Views photography is shot by a vehicle, whose movement is available to fans online.

[The search for the Loch Ness monster has moved online, thanks to Google]

Googles foray into space is the first time StreetView imagery was captured beyond planet Earth.

In a blog post about his experience, Pesquet wrote that it was difficult to find the words or take a picture that accurately describes the feeling of being in space.

Working with Google on my latest mission, I captured Street View imagery to show what the ISS looks like from the inside, and share what its like to look down on Earth from space, he added.

The virtual tour allows users to peek into areas where astronauts eat, exercise, work and even bathe.

Pesquets imagery reveal an environment that may look a bit cramped and chaotic if not altogether dizzying to humans anchored on earth, but some of the scenes from inside the ISS are downright mesmerizing.

The images were captured using DSLR cameras and then stitched together back on earth to create panoramic views.

Pesquet noted that the ISS is a busy place with six crew members working and researching 12 hours a day.

There are a lot of obstacles up there, and we had limited time to capture the imagery, so we had to be confident that our approach would work. Oh, and theres that whole zero gravity thing, he wrote.

Floating through the ISS online, youll notice clickable dots with detailed descriptions of the space and its objects to help viewers understand what theyre looking at. Pesquet noted that this is the first time annotations helpful little notes that pop up as you explore the ISS have been added to Street View imagery.

The ISS is a large spacecraft that orbits around Earth at more than 17,500 miles per hour and is home for astronauts from around the world, according to NASA. The ISS is made up of many pieces that were constructed by astronauts beginning in 1998. By 2000, as more pieces of the station were added, the station was ready for people, according to NASA. Portions of the station are connected via modules known as nodes, according to NASA.

The first crew arrived on November 2, 2000, NASA wrote. People have lived on the space station ever since. Over time more pieces have been added. NASA and its partners around the world finished the space station in 2011.

NASA compares the inside of the station to the inside of a house, noting that the structure which weighs almost one million pounds and covers an area the side of a football field has five bedrooms, two bathrooms, a gymnasium and a big bay window.

The station houses labs from the United States, Russia, Japan and Europe.

We can collect data on the Earths oceans, atmosphere, and land surface, Pesquet wrote. We can conduct experiments and studies that we wouldnt be able to do from Earth, like monitoring how the human body reacts to microgravity, solving mysteries of the immune system, studying cyclones to alert populations and governments when a storm is approaching, or monitoring marine litter the rapidly increasing amount waste found in our oceans.

Several times a week, Mission Control at NASAs Johnson Space Center in Houston determines where Earthlings can spot the station from the ground below from thousands of locations all over the globe. To find out the best time to see the station from your town, click here.

Read more:

How doctors used virtual reality to save the lives of conjoined twin sisters

How a fish tank helped hack a casino

Samsung to manufacture iPhone chips for Apple again, report says

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Summer program aims to send students’ coding projects to space – The Mercury News

Posted: at 7:50 am

Fly me to the moon, let me play among the stars, students sang in a large Campbell Middle School classroom as they tucked away their workbooks and laptops.

They werent rehearsing to form a Frank Sinatra tribute band. Crooning the tune is the celestial motivation for a group of roughly a dozen students hoping to get their lines of code to the International Space Station this summer.

The Zero Robotics program at Campbell Middle aims to take students work to the moon and beyond, all while teaching students about space exploration, computer science and coding.

The five-week summer program is an offshoot of a national high school program and competition provided through a partnership between MIT Space Systems Lab, the Innovation learning Center and Aurora Flight Sciences. It is sponsored by NASA, the Center for the Advancement of Science in Space and the Northrup Grumman Foundation.

The program sees students learn about efficient use of fuel and how to write specific lines of code. Once theyve had enough practice on and off the computer, students write and send the best line of code to the competition in their respective state. There are nine other teams in California competing.

Students must complete objectives, such as navigating around obstacles, docking to other satellites or going in a particular direction, all while conserving the most amount of fuel possible.

Winning teams will get their code uploaded to the International Space Station and watch via a live feed as small robots aboard the space station follow their program. The robots are similar to the ones students work with in the program back on Earth.

Students participate in a game to program movements for synchronized, position, hold, engage, reorient, experimental satellites, or SPHERES for short.

I thought the SPHERES would be shaped like the Earth, but they are shaped like a 3D octagon, said sixth-grade student Tamba Bangurah.

This is the first year students from the Campbell Union School District have participated. Summer camp program coordinator Tanner Marcoida said he had been planting the seed among some students toward the end of the school year to generate interest in participating.

If we have the best code out of our region, then our code will be uploaded to the space station and we will get to see the SPHERES, the actual robots that are on the space station in zero gravity, he said. We actually get to see them play out the game that they have been coding this entire time. Thats quite the treat for hard work.

Documenting the middle school students feat is a film crew from National Geographic.

Marcoida and his students have had Thomas Verrettes film crew follow their daily lessons and games and it will stick around until the final winner is announced.

I didnt know what school I would be in at the time, what students Id be following and the educators, Verrette said. I used the orientation as that resource. I watched how all the educators responded to the program and interviewed quite a few of them and then decided on Campbell.

After deciding Marcoida and his students would be an interesting group to film, he showed up the second day of camp with cameras to get the students used to the crew and having cameras in the room.

The kids are great, Verrette said. Every once in awhile theyll smile and laugh because they forget that were there. In some ways they are a lot easier to deal with than adults when youre trying to document something.

Verrette said he hopes when the documentary is complete and released, people have a newfound respect for science.

As for a release date, Verrette said that is to be determined.

For more information about Zero Robotics, visit zerorobotics.mit.edu.

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Key Parkinson’s Protein Gets Starring Research Role on International Space Station – Parkinson’s News Today

Posted: at 7:50 am

When a resupply mission lifts off in August bound for the International Space Station, it will be carrying an important cargo for researchers studying Parkinsons disease: aprotein consideredto be a key to potential future therapies.

Theleucine-rich repeat kinase 2(LRRK2) protein will be the focus of an experiment conducted on the Space Station.It is hoped that the microgravity conditions aboard the Space Station will allow growth of larger, more regular LRRK2 protein crystals, which would help scientists solve the proteins structure providing valuable information for thedesign of optimized therapies to fight Parkinsons disease (PD).

The experiment is the result of a partnership between theMichael J. Fox Foundation for Parkinsons Researchand the Center for the Advancement of Science in Space (CASIS).

Were thrilled that PD research has been selected to travel to the International Space Station and honored to partner with CASIS on behalf of the PD community here on Earth, said Michael J. Fox, the actor who started the foundation after he was diagnosed with Parkinsons, in a video message played at the International Space Station Research and Development Conference held in Washington, DC, July 17 20.

The SpaceX CRS-12 cargo resupply mission scheduled for liftoff in August will carry LRRK2 protein to the Space Station to be used in the Crystallization of LRRK2 Under Microgravity Conditions (CASIS PCG 7) experiment.

In its role as manager of the Space StationsU.S. National Laboratory, CASIS is responsible for coordinating transfer of scientific materials to and from theSpace Station and oversight of work conducted in the laboratory. The Michael J. Fox Foundation, which initiated this project, has supported earthside preparation of the protein for growth in space.

Advancing Understanding of LRRK2 as a Key Parkinsons Drug Target

LRRK2 is considered to be the greatest known genetic contributor to Parkinsons disease, according to the Michael J. Fox Foundation. Most Parkinsons cases are categorized as idiopathic of unknown cause with only about 10 percent of cases having been linked to a genetic cause. LRRK2 gene mutations are the most common cause of Parkinsonsin that minority, which represents only 1 to 2 percent of total Parkinsons cases.

However, LRRK2 mutations account for a much higher proportion of Parkinsonscases among people of certain ethnic groups, notably Ashkenazi Jews, North African Arab Berbers, and Basques, than they doin the general population.

The foundationnotes that while estimates vary, it is believed that mutated LRRK2 (predominantly the mutation scientists refer to as G2019S) account for some 15 to 20 percent of Parkinsons cases among Ashkenazi Jews, and about 40 percent of cases in North African Arab Berbers. Also, other genetic changes in LRRK2 have been found to increase risk of developing Parkinsons among people of other ethnic backgrounds, such as in Asians of Chinese descent.

Because LRRK2 protein function is heightened in people with Parkinsons disease, and is associated with a mutation in the LRRK2 gene, the foundation believes therapies targeting this gene could also accelerate development of treatments that can benefit a broader Parkinsons population.

However, one obstacle holding back this line of drug development is the limited understanding of LRRK2s exact structure. The foundationnotes that greater understanding of a proteins shape and structure can help developers design therapies more likely to engage a particular protein in treatment of disease.

Overcoming Gravitational Limitations

Earths gravitational field allows only low resolution versions of LRRK2 protein to be grown. However, the Crystallization of LRRK2 Under Microgravity Conditions (CASIS PCG 7) experiment will use automated biotechnology devices operating in the microgravity environment to grow larger, better-formed protein crystals with fewer defects that may yield higher resolution views of LRRK2. These will then be returned to Earth for postflight analysis.

Having a better detailed view of the precise shape and morphology of LRRK2s crystalline structure would help scientists better understand Parkinsons pathology, and accelerate development of LRRK2 inhibitor therapies designed to prevent, slow, or stop Parkinsons disease progression.

The unique environment of the International Space Station untethers research from restrictions imposed by gravity,CASIS president and executive director, Gregory H. Johnson, said in a press release. CASIS is glad to partner with The Michael J. Fox Foundation to explore the structure of this important piece of the Parkinsons puzzle.

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SpaceX’s Mars Plans Hit a Pothole. Up Next: the Moon? – WIRED

Posted: at 7:49 am

Elon Musk speaks at the International Space Station Research and Development Conference in Washington, D.C. on July 19, 2017.

Aaron Bernstein/Reuters

Its been less than a year since Elon Musk announced his plans to settle humans on Mars during a talk in Guadalajara, Mexico. On stage at the International Astronautical Congress, the billionaire invoked the lore of Hitchhikers Guide to the Galaxy and Battlestar Galactica while describing a massive passenger ship loaded with the essentialsyou know, like a movie theater and a restaurant. SpaceX hoped to launch these breezy cruises to the red planet in the early 2030s.

Plot twist: Musk's original vision is no longer canon in his universe. On Wednesday, Musk took questions during a keynote discussion at the International Space Station R&D conference in Washington, DC. In between dad jokes about tunnel digging , a staple artificial intelligence threat assessment , and a spirited attempt to unpack the potential for interplanetary war, he candidly revealed a series of obstacles for SpaceX and its plan to build a city on Mars. SpaceX is rebooting its colonization plan, and may pivot to focus on a moon base that would aid that effort.

The Hawthorne, California-based spaceflight company has spent years touting propulsive landing technology for the next version of its Dragon spacecraft. SpaceX expected to equip the Dragon V2, rated for crew and cargo, with four small SuperDraco engines and deployable landing legs to allow for a guided surface touchdownfirst on the Earths surface, and then, maybe, on Mars. SpaceX was confident enough in the design to propose a variant of the vehicle Musk claimed would be able to land anywhere in the solar system.

The pitch for those uncrewed Red Dragon missions to Mars included a collaboration with NASA to gather landing data, test communications, and plan for potential contamination from Earth-based microbes. The space agency, of course, has its own boots-on-Mars ambitions, and hopes to send astronauts to the red planet aboard the Orion spacecraft by 2040. Musk would later compare Red Dragon launches to a train leaving the station, delivering cargo and science to Mars in preparation for a human mission.

But now, SpaceX has pulled the plug on its prologue to an interplanetary future.

Musk explained that Red Dragon was no longer in line with the evolving vision SpaceX has for getting to Marsspecifically, the part where you have to land on Mars . The company is hitting pause on the development of its propulsive landing technology on the Dragon V2 spacecraft. Musk argued that while the technology works, SpaceX would be put through the wringer trying to meet NASAs safety standards for landing a human crew on the ground. It doesnt seem like the right way to apply resources right now, Musk said. Im pretty confident that is not the right way, and that theres a far better approach. He later tweeted that SpaceX would still land with propulsive thrusters on Mars, but with a larger spacecraft.

SpaceX has had a busy year adding to its growing arsenal of recovered rockets while launching more times than any other year since its founding. The company also managed to re-fly both its Falcon 9 rocket and Dragon cargo capsule . In the flurry of praise surrounding rocket landings and Mars concepts, the fact that SpaceX has yet to attempt or complete a deep space mission of any kind still weighs on the companys future. Red Dragon would have been SpaceXs first toe into the deep end of the pool.

Its journey would have begun atop the triple-booster Falcon Heavy rocket, the famously-delayed launch vehicle that Musk claims has over twice the payload capability of a single Falcon 9 rocket, able to easily deliver 100,000 pounds to low-Earth orbit. At the ISS R&D conference, Musk invited the audience and those watching the livestream to witness the launch of the vehiclecurrently projected for this fallfrom Kennedy Space Center. But he followed with an uneasy disclaimer: Real good chance that vehicle doesnt make it to orbit.

That uncertainty doesnt bode well for Musks original Mars ambitions. Musk argued that the Falcon Heavy was impossible to test on the ground due to the machines complexity. And he said that development was far more difficult than SpaceX expected, admitting that the company was naive in its original projections. The simultaneous firing 27 orbital engines notwithstanding, launching a Falcon Heavy includes changing aerodynamics, heightened vibration, and an enormous thrust that pushes qualification levels of the flight hardware to the limit. Musk admitted on Wednesday that limited damage to former Apollo 11 Pad 39A would be a win in the aftermath of the Falcon Heavy test flight. Along with Musk, the audience laughed nervously.

According to Musks keynote this week, SpaceX is planning to scale down its Mars-bound spacecraft to a size suitable for a wider range of missionsmissions that would help pay for its development costs. A size reduction would certainly have a large economic impact on manufacturing, but savings could be augmented by focusing all efforts on a single reusable vehicle that could serve both low-Earth orbit and deep space. And Musk also offered that building a base on the moon is essential to getting the public excited about space again and would be an excellent stepping stone toward Mars.

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But is that a suggestion to another company? To NASA? Or is SpaceX going to unveil plans for a moon base as part of their updated Mars architecture?

Elon Musk has said that he would offer priority seating to NASA for missions to lunar orbit. SpaceX was the first private company to dock with the space station and the success between the federal space agency and the spaceflight company could point to a continuing partnership that expands beyond low Earth orbit. The ISS wont be around forever, and with NASA shifting toward deep space exploration, the opportunity to give the agency a lift is there. Especially if NASA wants to return to the moon.

But that doesnt mean SpaceX is abandoning its Mars ambitions; far from it. SpaceX owes much of its financial and development success to its partnership with NASA, and theres no doubt Musk will pursue that partnership beyond low-Earth orbit. That means that NASA astronauts could one day be flying on these deep space missions under lucrative taxpayer-funded contracts. Before then, SpaceX will have to fully prove its technology, along with life support systems and radiation protection for crewed missions.

Just a week ago, Musk dispatched SpaceX VP Tim Hughes to make the case for deep space in front of the Senate Subcommittee on Space, Science & Technology. Hughes used the success of SpaceX and NASAs commercial resupply missions and the governing Commercial Orbital Transportation Services program to make a case for partnership in deep space exploration. "To this day, Americas achievement of landing men on the moon and returning them safely to Earth likely represents humankinds greatest and most inspirational technological achievement, he said. Now, other nations like China seek to replicate an achievement America first accomplished 48 years ago. Maybe SpaceX can add private companies to the roster.

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C9ORF72 Throws a Wrench into DNA Repair Machinery | ALZFORUM – Alzforum

Posted: at 7:48 am

21 Jul 2017

Hexanucleotide expansions in the C9ORF72 genethe most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementiamount a multipronged attack on the DNA repair system, according to a July 17 study in Nature Neuroscience. Researchers led by Mimoun Azzouz and Sherif El-Khamisy at the University of Sheffield in England reported that the repeat expansions trigger the formation of DNA-RNA hybrids, called R-loops, that break DNA. At the same time, the unusual dipeptide repeats (DPRs) translated from these expansions derail efforts to mend the damage. The researchers found evidence of broken DNA and a subpar repair response in mice expressing the expansions, and also in postmortem tissue from C9-ALS patients. They proposed that the onslaught of DNA damage in neurons ultimately leads to their demise, and that targeting the pathway could become a therapeuticstrategy.

DNA damage is a common hazard inside cells, and an extensive repair system exists to lessen its toll. Neurons are acutely dependent on this repair machinery, as they cannot easily wipe the slate clean through replication (see Pan et al., 2014).Making matters worse, oxidative DNA damage increases in the brain, and repair mechanisms start to falter with age and in the context of neurodegenerative disease (Sep 2011 news; Feb 2013 conference news).

Against this backdrop, El-Khamisy and colleagues wondered if an additional stressorC9ORF72 hexanucleotide expansionsmight add fuel to the fire. These expansions of the GGGGCC sequence exist in hundreds to thousands of copies in people with ALS/FTD. Both RNA foci formed from their transcription, and the DPRs generated by their translation, reportedly inflict damage on neurons. The researchers hypothesized that due to the expansions repetitive nature, and the abundance of GC repeats within them, the C9ORF72 expansions could be extremely prone to folding into R-loops, a type of DNA-RNA hybrid structure that can form during transcription (Aguilera and Garcia-Muse, 2012). R-loops are known triggers of double-stranded DNA breaks (Hamperl and Cimprich, 2014).

To learn if the expansions caused R-loops, first author Callum Walker and colleagues transfected the expansions into human fetal lung fibroblasts. Then they probed with antibodies specific to R-loops and phosphorylated histone H2AX, an established indicator of double-stranded breakages. Indeed, they found that cells expressing 102 repeats that could not be translatedand thus only formed RNA foci, not DPRsharbored elevated numbers of R-loops and breaks. This was also the case in cells transfected with constructs that did result in the translation of 34 or 69 DPRs. Notably, overexpression of senataxin, an RNA helicase known to resolve R-loops, reduced the number of breakages and even normalized the uptick in cell death the breakages triggered. Together, the findings suggested that the repeat expansions caused R-loops, which snapped DNA and harmedcells.

Cells transfected with dipeptide repeats (green) build up R-loops (red) in their DNA. [Courtesy of Walker et al., Nature Neuroscience2017.]

The researchers further wondered whether the repeat expansions would affect DNA repair. In both human fibroblasts and primary rat cortical neurons expressing the expansions, the researchers found the repair machinery to be profoundly hobbled. For starters, ataxia telangiectasia (ATM), the master DNA repair kinase, was hypophosphorylated and failed to activate when the researchers treated cells with DNA-damaging toxins. This led to a dismal nuclear recruitment of 53BP1, a factor that rejoins broken DNA, as well as subpar phosphorylation of another key ATM target,p53.

Through an extensive battery of biochemical and immunostaining experiments, the researchers zeroed in on the mechanisms that derailed the DNA repair machinery. The E3 ubiquitin ligase RN168 normally ubiquitylates histone H2A, an adornment that is needed to recruit 53BP1 to damaged DNA. However, in cells expressing the expansions, the researchers found RN168 tied up in p62 inclusions instead. This led to a reduction in ubiquitylated H2A and stymied 53BP1 recruitment. Interestingly, previous studies have reported that successful recruitment of 53BP1 to DNA helps sustain further ATM signaling (Lee et al., 2010). Therefore, RN168s entrapment in p62 inclusions could potentially derail the entire DNA repair process. In support of this idea, overexpression of RN168, or depletion of p62, restored 53BP1 recruitment and reduced the number of DNA breaks in cells expressing the repeatexpansions.

Strikingly, the researchers also observed R-loops, double-stranded breaks, and signs of weak ATM signaling in neurons from mice injected with viral vectors harboring the repeat expansions. These animals suffered a 20 percent loss in brainstem neurons, as well as motor deficits. The researchers proposed that DNA damage was the primary cause of this neurodegeneration, a hypothesis they will test by overexpressing senataxin and/or RN168 in the animals, El-Khamisy toldAlzforum.

The researchers also found evidence of DNA in disrepair in postmortem spinal cord tissue from ALS patients, which were wrought with R-loops, double-stranded DNA breaks, and signs of ATM signalingdefects.

Repeat Assault. In the proposed model, C9ORF72 repeat expansions damage DNA and thwart its repair. [Courtesy of Walker et al., Nature Neuroscience2017.]

The researchers proposed that C9ORF72 hexanucleotide expansions attacked DNA via two distinct, yet intertwined, pathways: through directly causing damage via R-loops, and by dismantling ATM-mediated DNA repair. El-Khamisy proposed that the repeat-laden RNA causes R-loops, while the DPRs manifest the p62 inclusions that sequester RN168 and disrupt repair. Interestingly, the latter pathway meshes with other recent findings implicating RN168 sequestration in p62 inclusions in the disruption of DNA repair (Wang et al., 2016).

Walkers findings dovetail with a previous study led by Li-Huei Tsai of MIT, which reported that the ALS gene FUS is recruited to DNA breaks and helps orchestrate repair (Sep 2013 news). The findings of the current paper are very consistent with ours, and together make a strong argument for the role of unrepaired DNA breaks in ALS, Tsaicommented.

This paper is particularly well done, commented Ray Truant of McMaster University in Hamilton, Canada. It really establishes ATM-mediated DNA repair as a common node in neurodegenerative disease, hesaid.

Truant recently reported that mutated huntingtin protein disrupted DNA repair (Maiuri et al., 2017). He added that as reactive oxidation builds in the brain with age, the efficiency of the DNA repair response could strongly influence the onset of neurodegenerative disease, a hypothesis supported by recent genome wide association studies (Bettencourt et al., 2016;Jones et al., 2017).

The study also provides researchers with a number of therapeutic targets, some of which may prove useful across neurodegenerative diseases, Truant added.JessicaShugart

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Who Killed Robin Brooks? DNA Technology Helps Paint Portrait of Killer – FOX40

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ROSEMONT -- Cold case investigators said Robin Brooks was raped and stabbed to death inside her apartment in the Rosemont area of Sacramento County more than 37 years ago.

Detectives have a full DNA profile of the suspected killer from his blood, but the case is still unsolved after all these years. But now, new technology is giving detectives a different way to look at the DNA and a glimpse at what the killer could possibly look like.

Its called DNA phenotyping. It sounds like science fiction, but this forensic method uses an unknown suspects DNA to create a composite sketch of the mystery persons physical characteristics.

Its not intended to be a photo ID, said Dr. Ellen Greytak over the phone to FOX40. Its a genetic witness in the absence of an eye witness.

Doctor Greytak works for Parabon NanoLabs, a Reston, Virginia-based biotech company that offers the tool called Snapshot. The Sacramento County Sheriffs Department has contracted the company to come up with two profiles of the suspected killer in Brooks unsolved murder case.

We have DNA, we have the person who did this, said retired Sacramento County sheriffs Detective Micki Links. There's no doubt about who it is. We just need their name.

The DNA profile of the suspected killer in Brooks case was put into all the criminal databases in 2004, but a match has never been made.

Links said she believes these two profiles will aid in the investigation by giving fading memories a look back at what the killers face may have looked like when he was 25. Another profile has the suspect aged to 56.

Links also shared new details on Robins whereabouts before her death.

For decades, investigators thought Brooks finished her shift at Donut Time off Keifer Boulevard and walked straight home to her apartment on Tallyho Drive. That apartment has been renamed the Garden Club Apartments.

But detectives said an informant, who has been cleared as a suspect, has come forward with a different timeline. He told them he saw Brooks at a house party somewhere off Roseport Way. The unnamed informant also told investigators Brooks went to the party after work and then went home.

The informant added that the party was made up of mostly teens, between 15 and 19 years old, many from Hiram Johnson High School and the nearby Lincoln Village.

You're not going to get away with this, said Links. I'm going to do whatever I can to find you, and make you pay for what you did.

Robins family is also still fighting for answers. Maria Arrick, Robins older sister, is offering up to a $10,000 reward for information that leads to the arrest of Brooks killer.

If you have any information regarding this case, please contact the Sacramento County Sheriffs Department main homicide line at (916) 874-5057. Or you can go to a special website set up for the victims of unsolved homicides in Sacramento County.

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Police: DNA links Decatur man to April burglary – The Decatur Daily

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A Decatur man was arrested Thursday after DNA collected from the scene of a burglary matched his DNA in the CODIS criminal DNA database, Decatur police said.

Eric Deondre Warner, 35, of 416 10th Ave. N.W., was charged Thursday with third-degree burglary, police said.

On Monday, DNA collected from the scene of the burglary matched with his DNA, which was on file in the CODIS database, police said.

On April 19, a burglary in the 400 block of Finley Drive N.W. was reported to police, reports show. The victim said items were taken from the home and it was "completely ransacked," according to reports.

Investigators were able to collect DNA evidence from the scene, which ultimately led to Warner being developed as a suspect, police said.

Warrants for Warner's arrest were obtained Thursday and were served on him in the Morgan County Jail, where he was incarcerated for other charges, police said.

Bail for his new burglary charge was set at $2,500.

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Removal of Aging Cells to Increase Longevity – Anti Aging News

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1167 1 Posted on Jul 21, 2017, 8 a.m.

Researchers find that a targeted removal of senescent cells could delay the onset of age-relateddegenerative joint conditions,such as osteoarthritis.

An international team of professional researchers joined forces to conduct a study that confirmed the targeted removal of senescent cells that collect in vertebrate tissue across the aging process contributes to delaying the onset of pathologies related to aging. The research was led by the Johns Hopkins University School of Medicine researcher Dr. Chaekyu Kim. He worked in tandem with the Johns Hopkins University School of Medicine's Dr. Ok Hee Jeon. Additional contributors from the University of California, Berkeley, the Mayo Clinic College of Medicine, the University Medical Center Groningen and the Buck Institute for Research on Aging and Unity Biotechnology, Inc. also played a part in the research. The findings were published this past April in the journal Nature Medicine.

About the Study

The research team presented a new pharmacologic candidate for the alleviation of degenerative joint conditions like osteoarthritis (OA) that are age-related. This occurs through the selective destroying of senescent cells known as SnCs. Such cells gather throughout the aging process in the body's vertebrate tissues. They are located at areas where age-related pathology occurs. Though such cells play an important role in the healing of wounds and repairing injured body sites, they might also lead to the onset of cancer within tissues. As an example, in particular joints like the knees and other cartilage tissues, SnCs are not always cleared from the area following the injury. This leads to the continuation of OA development.

In order to test the notion that SnCs might play a role in OA development, the researchers cut the anterior cruciate ligaments in young and old mice to a mimic a similar injury in human beings. The researchers applied injections of the experimental drug known as UBX0101 to remove SnCs following the anterior cruciate ligament transection surgery.

Preclinical studies in human and mice cells suggest removing SnCs dramatically decreases the development of post-traumatic OA as well as related pain. Removing SnCs also creates a prochondrogenic environment that allows for the growth of new cartilage and joint repair

The Findings

The findings suggest the selective removal of aged cells from the body's joints might decrease the development of post-traumatic OA. This selective removal might also allow for the growth of new cartilage and the repairing of joints. Aged mice did not show signs of any cartilage regeneration following the treatment applied through UBX0101 injections. The findings are relevant to human disease through validation with the use of chondrocytes isolated from patients who suffer from arthritis. The findings offer important insights into therapies keying in on the use of SnCs to treat trauma as well as degenerative joint disease related to the aging process.

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How Having Eczema on My Face Changed My LifeFor the Better – Health.com

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I have had eczema since I was a little girl, but it was neverterribly debilitating. I had some scratches on my neck, arms, and legs, but I never thought too much of it. And I was lucky to haveclear skin on my face. Other thana pimple here or there, my complexion was generally even and bright, andI neverneeded to use foundation.

That all changed this past May.Perhaps triggered by acombination ofpoor diet and taking too many medications, my eczema finally reared its ugly head in full force. Despite never having hadfacial eczemabefore, I started experiencing symptoms around my eyeswithin the next few months, it would consume my entire face, neck, arms, and upper legs.I ended up visiting countless doctors, starting a clean diet, and buying every product out there that claimed to be eczemas miracle cure.

I wish I could tell you that Im now free of eczema symptoms, butIhave a long ways to go. My face is still bright red, raw, and itchy. My legs and neck have inflammation, and I struggle to wake up every day feeling happy and healthy.

Did myskin issues make me feel down about myself at times? Sure. But succumbing to that way of thinking only made memore depressed.What has helped: understanding that my struggle with eczema is actually key to appreciating my life even more. Here, five ways the skin condition has helped me gain perspective and live a more fulfilling life.

RELATED: 9 Things You Should Never Do If You Have Eczema

1. I care less about looks. In the past, I couldn'tleave the house without eye makeup.In fact, I cant remember a time when I was able to confidently go outside without my trusty eyeliner. Now? I truly feel beautiful without makeup. Even when my facial eczema completely clearswhich I know it willI plan on wearing a lot less makeup than I used to. Im finally comfortable in my own skin.

2. In a strange way, I've become more confident. During my worst flares, when my face was red and sore, I found that I actually felt empowered. Sure, I cried and felt ugly at first. But I foundstrength from within to muster up thecourage to continue my day. Once that happened, I felt like I could take on anything.

3. Ibecame more empathetic. As clich as it might sound, I've realizedthat everyone is fighting their own battle. Sure, mine might be more noticeable, but I've become moreunderstanding that no one's life is all peaches and sunshine.

4. I focus more on health. I admittedly used to eat way too many cookies, cake, friesyou name it. As a result,I was constantly fatigued, no matter how many hours of sleep I got. Sinceimproving my diet by cutting out unnecessary sugarand consuming more leafy greens,I feel more alive. Another plus? I lost 10 pounds.

5. Iknow whos there for me. I didn'talways handle my eczema wellI avoided seeing people, I worked from home, and I didn'twant to look my boyfriend in the eye. But the experience has helped me realizewho truly loves me for me. My boyfriend, for example, continues to tell me Im beautiful every day. So whatif other people want to make comments or stare? They dont matter.

Have eczema, psoriasis, acne, or another conditionmessing with your confidence? Know that youre so much more than your skin, and you cant let it tell you how worthy you are. Do I still struggle with myself? Of course. But I now know that it willalways get better.

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