Daily Archives: July 20, 2017

Intermountain, Stanford University see promise for precision medicine in cancer cases – Healthcare IT News

Posted: July 20, 2017 at 2:44 am

Recent research from Intermountain Healthcare's clinicians shows the successful application of genomic-based approaches to studying individual cancer cases.

Oncologists Lincoln Nadauld, MD, and Derrick Haslem, MD, work at the Southwest Cancer Center in St. George, Utah. In addition to treating patients, they conduct research aimed at improving cancer care and precision medicine.

Their recent research has been published in two national peer-reviewed journals in collaboration with Intermountain Healthcare doctors and researchers from Stanford School of Medicine.

[Also:Precision medicine: Hype today but the promise is even bigger than we think]

One study outlines what the doctors call an "impressive" clinical course and positive outcome of a patient with metastatic colon cancer treated with a precision oncology approach. It was published in the Journal of Clinical Oncology-Precision Oncology, a research publication outlet from the American Society of Clinical Oncologists.

The second publication, co-authored by Nadauld and published in Genome Medicine, shows that linked read sequencing is useful in characterizing oncogenic rearrangements in cancer metastasis.

Both studies were done in collaboration with Hanlee P. Ji, MD, senior associate director of the Stanford Genome Technology Center and Associate Professor at Stanford's School of Medicine.

Linked read sequencing, the researchers note, is a process that allows scientists and doctors to look at the molecular structure of tumor DNA in longer reads of 50,000 base pairs, as opposed to the typical 200-300, and thus "revealing the genomic complexity of patient tumors."

In reference to the Genome Medicine study, Nadauld points out: "In this patient, we were able to identify an amplification of a gene called FGFR2, which is critical because there are drugs that target that mutation.

"This case indicates there are broader applications for linked read technology, including diagnostic purposes and defining additional treatment options for patients along with new genes to target," he added. "With further study, pharmaceutical and biotech technologies can start to develop new drugs that target different molecular phenomena."

Twitter: @Bernie_HITN Email the writer: bernie.monegain@himssmedia.com

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INSIDE THE GAME: No chanting, no more retired numbers, please – MyWebTimes.com

Posted: at 2:43 am

Its all a matter of taste.

I have many friends and acquaintances, and among them, for every person who thinks of me as this nice, amiable person who tries to be a ray of sunshine wherever he goes, theres another who knows that at times I can make Clint Eastwoods Get off my lawn character in Gran Torino seem like Mary Poppins on Valium.

I dont like to offend people, but what I have to say might, on occasion. Here go a couple of thoughts I hope will be food for discussion, not food for dissent.

As I related inour Tweet of the Day on the front of The Times Sports section this week, in all my time playing, watching and covering baseball in my 50-some years on this planet, I dont remember anyone in a dugout chanting hes a SLUG-ger, hes a SLUG-ger when it was Anthony Rizzos turn to bat, or hit a HOME run, hit a HOME run whenever Aaron Judge or Giancarlo Stanton got in the box, and they CERTAINLY never did anything like num-BER SEV-en, num-BER SEV-en when Mickey Mantle stepped to the plate. Wow, that last one sent a cold shiver down my spine.

Saw Bull Durham the other day and Im more in line with Robert Wuhls character, Larry Hockett, when he spit out rapid-fire through a mouthful of seeds, Cmon, baby, you got this, you got this, its you, baby, its you, cmon, baby to Bulls on the field or at the plate.

I know Little Leaguers are not supposed to yell Swing! at the batter anymore, but what happened to the old standard hes no batter, hes no batter, aaAAaaAA and other encouragement to a pitcher? Please just something not near as mind-numbingly annoying as the rhythmic nonsense being spewed the last few years. I might expect that from softball, but in baseball? No thanks.

It deserves a place in the baseball dumpster along with The Wave, the White Soxs uniform shorts and Chris Bermans calls of the Home Run Derby.

Try this: No MORE CHAN-ting, no MORE CHAN-ting.

Roberto Clementes number

Im going to tread lightly here because my opinion might offend some who are sensitive to matters of race. Believe me, it has nothing to do with race, gender or religious beliefs. It has to do only with my view of the game.

I do not believe Roberto Clemente should have his number 21 retired through all of MLB the way Jackie Robinsons 42 is.

I know what a tremendous player Clemente was, having seen him many times in action against my Cubs on WGN back in the day and in the national broadcasts of the World Series the Pirates played in. Hes an all-time great, in addition to being a generous, caring individual who died while delivering humanitarian aidto storm victims in Nicaragua.

No doubt, no question, he deserves to be the icon to the Hispanic community that he is.

But I personally don't feel the challenges he overcame on his way to the majors are at the same level of those traversed by Robinson when he broke the MLB color barrier in 1947.

Looking at it another way, if Clemente deserves that honor, why not Hank Greenberg or Sandy Koufax for being the greatest Jewish players of all time? Why not Honus Wagner as the hero of Americas extensive, generations-deep German population? Why not Joe DiMaggio for all those fans of Italian descent?

This is opening a can of worms with so many arguments, some of them so politically incorrect that I wont go there.

I didnt agree with Robinsons 42 being retired across the leagues when it happened. Like Clemente, Robinson is an incredibly talented figure in the game and a man of immense character, patience and tolerance. His impact on the game is undeniable. I just dont see Clementes impact being as significant in the history of baseball.

OK, all that now said, I add the immortal words of comedian Dennis Miller: Of course, thats just my opinion. I could be wrong.

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College Students Can’t Learn If They Won’t Listen – The Daily Caller

Posted: at 2:43 am

The First Amendment is in a state of emergency on the college campus. Destructive protests in opposition to free speech have broken out nationwide in the last few years, threatening a right and principle that students once championed.

In fact, the First Amendment emergency is so severe that the Senate Judiciary Committee held a hearing June 10 to receive input from experts on the issue.

A Pew poll released July 10 shows the majority of Republicans think colleges have a negative impact on America. I value my college experience, but I understand how people can feel left out and betrayed by academia.

I have witnessed it firsthand. I helped host Ben Shapiro, a conservative commentator, at the University of North Carolina at Chapel Hill through the College Republicans in the spring of 2016. While sitting on the front row of his public lecture, I videotaped a protest against free speech that is all too typical on college campuses today.

About a third of the 400-person auditorium was composed of left wing students dressed in black. These students staged a walk-out about a minute into Shapiros opening remarks, refusing to heed his calls to learn a new yet controversial perspective.

Shapiro made the argument that parenting, not race, is the dominant factor in setting up young people for success in life. He claimed the political left uses race as a wedge issue, while the right attempts to judge people by the content of their character. I tend to agree.

The protesters went outside the lecture hall to hold a rally against perceived racism and bigotry while dozens of tolerant conservative and liberal students poured into their empty seats to hear Shapiro.

I sent the video into Campus Reform, a website dedicated to covering left wing intolerance in higher education. Later that year, I interned as a correspondent for the outlet and covered similar stories.

Through the Shapiro walkout and Campus Reform internship, the scope of the college free speech crisis became clear to me. Many of the countrys brightest young minds cannot bear to hear opinions different from their own, and they will go to extreme lengths to shut out diverse thought.

This should alarm citizens concerned about the state of free speech in society, as positive societal advancements are driven by constructive dialogue and criticism. Opposition to free speech in the nations top academic enclaves threatens to stall the progress of American prosperity.

Speech codes, safe spaces, protests against minority opinionsoften those held by conservativesand attempts at keeping politically incorrect speakers off campus have made colleges some of the most intolerant places in America.

In the fall of 2015, students at Yale University hysterically confronted Nicholas and Erika Christakis, two married professors serving as residential directors. The students were upset after Mrs. Christakis called into question the illiberal condemnation of culturally appropriate Halloween costumes.

The professor eventually resigned because her students could not live and learn with someone who refused to cloak them in an intellectual and emotional bubbleleftist intolerance has claimed victims.

A protest at the University of California, Berkeley approached the definition of a riot this spring. There, a black-clad mob effectively shut down a speech scheduled by Milo Yiannopoulos, an outlandish free speech provocateur of the alt-right.

The protest against Yiannopoulos drew national media attention, and subsequent speaking attempts made by other right wing figures were met with threats of violence and dissuading letters from university administrators.

In the 1960s, Berkeley students protested when administrators prevented communist speakers from addressing the campus. Now they shut out speakers whom they deem deplorable. The original home of the college free speech movement of the 1960s became the epicenter of the anti-free speech movement of today.

College students should test their beliefs through exposure to new ideas and debate. Learning from diverse perspectives can strengthen their intellectual growth. You can find another opinion repulsive, but still accept its right to be spoken.

By welcoming all forms of free speech on the college campus, students and administrators may grow in empathy and knowledge. This will add value to the college degree and help prepare Americas future leaders for a diverse world.

I wish that the protesters at the Shapiro lecture had stayed to hear what an intelligent stranger had to say and engaged in debate. Leaders from student government, ethnic groups, and social justice coalitions were among the crowd that refused.

We need voices for tolerance and free speech at all levels of the education and public policy communities. Opinion leaders should stand up and speak out for the rights of everyone to be heard.

Will Rierson is a senior at the University of North Carolina at Chapel Hill, where he is chairman of the College Republicans. He has participated in the Koch Internship and Fellow programs.

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Chris Hemsworth Says ‘It’s Time’ For A Woman To Play James Bond – The Daily Caller

Posted: at 2:43 am

Chris Hemsworth is best known for his role as the Norse god Thor in the Avengers movies. But outside of cinema, Hemsworth has had a hard time fitting in with the progressive left, who have slammed him for violating every progressive tenet, ranging from cultural appropriation to transphobia.

Unable to stop making politically incorrect gaffes, Hemsworth has now taken it upon himself to call for a woman to play the role of the next James Bond.

In an interview with W Magazine about the new film Atomic Blonde, the actor revealed that he would like to see Charlize Theron take on the role.

She embodies every ounce of strength and nobility and dignity and integrity that that character should have, he said, perhaps forgetting that as a character, James Bond embodies every bit of the toxic masculinity feminists complain about. Hes a womanizer, and a drunk, who has on multiple occasions expressed misogynistic views toward women or treated them as little more than sexual conquests who usually end up dead.

Several actors had been suggested to fill in the void left by Daniel Craig, who has said hed rather break this glass and slash [his] wrists than perform as James Bond for a fifth time, despite being contracted to do so. Tom Hardy, Tom Hiddleston and Idris Elba have been listed as potential candidates to play the character, though Craig is now expected to be back for the next film. The X-Files and The Fall star Gillian Anderson expressed interest in the role of Jane Bond, if it was available.

Shes smart as hell. Shes physically able. You know watching her in those fight scenes, doing it in high heels by the way and 8-foot long gown [in Snow White and the Huntsman], was even more impressive, said Hemsworth of Theron. And I just think why not? Its time.

Theron told E! News said she was flattered by his remarks. Wow, thats just so insanely generous and nice. I dont even know what to do with that, Theron said. Thats really sweet.

There is little doubt that Theron has the acting chops to effortlessly deliver any character she portrays, but perhaps Hemsworth should take a step back and realize she might be better off playing a new character instead of slipping into the role of a character thats been rode hard and put away wet.

Ian Miles Cheong is a journalist and outspoken media critic. You can reach him through social media at @stillgray on Twitter.

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Congress scion has opposition within, as he skips debate on farmers’ plight – Economic Times

Posted: at 2:43 am

NEW DELHI: There were murmurs in Congress circles in Parliament over party vice-president Rahul Gandhis absence in the Lok Sabha during Wednesdays hardearned debate on farmers distress. Though his absence was justified by citing a scheduled rally in Rajasthan on Wednesday afternoon over the same issue, the fact that he chose to miss the debate that the Congress-led united Opposition had wangled after staging a series of protests and forcing three adjournments of the House in Gandhis presence left many wondering whether Gandhi has his priorities right.

It looks like a case of Rahulji preferring a district stage over a national platform to address a burning national issue, said a party MP. Many wondered why he let his Rajasthan trip clash with the debate since it was a forgone conclusion that the Opposition would seek a debate on farmers issue. They said he could have held the rally before the session or during the weekend. With the leader missing, Congress fielded Jyotiraditya Scindia to open the debate, with a strong denouncement of Centres handling of farmers issues.

There is no clarity on whether the debate will conclude on Monday or spill over to next working days so that Gandhi can catch up. As per government-Opposition pact, Parliament will adjourn on Thursday after Question Hour as counting of votes in presidential poll will be held then. Gandhi is expected to skip Parliament on Friday too, to address a Dalit conference in Bangalore.

Congress leaders want Gandhi to make best use of the session for two reasons: As opposition parties unite over several issues, they want Gandhi to emerge as the leading voice. Secondly, given this could be the last session before his planned takeover as party chief, they hope he will make an effort to repair his sloppy parliamentary track-record to set the right atmospherics.

However, his absence during Wednesdays debate made them mindful of his penchant for vanishing acts at politically incorrect times. He had gone abroad last year for two months at the height of the Congress agitation against the land acquisition bill and on a 20+ day trip to Europe during Oppositions unity show over farmer suicides, cow vigilantism and during pre-presidential poll deliberations.

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Editorial: The social demise of civility – Calgary Herald

Posted: at 2:43 am

Trolls are taking over the Internet. John Lucas / Edmonton Journal

Its an exercise in restraint these days when it comes to comments on articles, tweets or other social media posts regarding news stories.

The restraint needed is on the part of the reader, to not want to gouge ones eyes out after digesting the intense vitriol some posters have for their fellow citizens.

It almost doesnt matter what or whom the story is about; everyone has an opinion that, too often, many mistakefor fact.

Whether its about the NDP, the Liberal prime minister, the Republican president, terrorists, city hall or even anthem singers at ball games, trolls are waging war on respectful dialogue, one keyboard stroke at a time.

Some recent examples include telling a local singer that her rendition of the Canadian anthem is a national embarrassment and she owes the country an apology; that Justin Trudeau is a super sad excuse for (expletive) prime minister and a joke across the planet; that a former prime minister is a racist among other unprintables, and another politician is an ignoramus and a clown.

Ever since the advent of social media, there have been those who relish stirring the pot with a few chosen online slurs.But those drips of literary poison have turned into a torrent of verbal abuse.

Trump certainly didnt cause this to occur but it could be argued that his presidency has lent a certain credibility to this behaviour. Because the leader of the United States feels empowered to speak his mind so freely, regardless of consequence, others are following suit. Those who have been chastened in the past for politically incorrect, socially unacceptable opinions, now broadcast them proudly, almost daring the other side to respond.

This is not to say that people should not hold diverse opinions. Public debate is essential in a free and democratic society. Its how we keep our political parties in check. Its how we keep society as a whole in line.

But theres a not-so-fine line between polite disagreement over the facts and hate-filled personal attacks on the person.

If opposing sides were to debate their points in person, one would hope theyd never unleash the diatribe they do anonymously online.

Faceless rants do not solve issues or sway anyones opinion. They just harden the heart and add to the breakdown of society.

We need a return to civility. If you wouldnt say it out loud in a crowd, dont type it. Think deeply, do the research and then intellectually express your views while respecting those who hold other views. Its not about winning; its about sharing.

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China’s cyber watchdog orders top tech platforms to increase self … – Reuters

Posted: at 2:43 am

BEIJING (Reuters) - China's top cyber authority ordered the country's top tech firms to carry out "immediate cleaning and rectification" of their platforms to remove content deemed offensive to the Communist Party and the country's national image, it said on Wednesday.

The watchdog held a meeting with representatives from firms including Tencent Holdings Ltd, Baidu Inc and Sohu.com Inc, on Tuesday where it gave them a list of specific errors, the Cyberspace Administration of China (CAC) said in a statement on social media.

The violations include distorting Chinese history, spreading fake news, misinterpreting policy directives and failing to block content that subverts public stability.

"[The sites] must adhere to the correct political line and moral norms," the statement said.

Chinese authorities have recently cracked down on platforms that allow users to share media from outlets that are not sanctioned under state-issued licenses, amid a wider censorship campaign spearheaded by President Xi Jinping.

On June 1 the CAC ushered in new regulations requiring all offline and online media outlets to be managed by Party-approved editorial staff. Workers in the approved outlets must receive training from local propaganda bureaus.[nL4N1I42ID]

In the wake of the new regulations several sites have been targeted with fines and closures under the watchdog's orders.

In specific examples, the CAC criticised one platform that failed to censor articles that "seriously deviated from socialist values" by saying China benefited from U.S. assistance during conflicts with Japan during World War II.

Other examples included a story detailing alleged affairs by party officials, an opinion piece that decried China's death penalty and an article that urged readers to invest in speculative real estate projects.

The CAC said the firms were required to immediately close offending accounts and strengthen "imperfect" auditing systems to avoid future punishment.

Reporting by Cate Cadell; editing by Susan Thomas

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Microsoft Bing Reverses Sex-Related Censorship in the Middle East – EFF

Posted: at 2:43 am

Imagine trying to do online research on breast cancer, or William S. Burroughs famous novel Naked Lunch, only to find that your search results keep coming up blank. This is the confounding situation that faced Microsoft Bing users in the Middle East and North Africa for years, made especially confusing by the fact that if you tried the same searches on Google, it did offer results for these terms.

Problems caused by the voluntary blocking of certain terms by intermediaries are well-known; just last week, we wrote about how payment processors like Venmo are blocking payments from users who describe the payments using certain termslike Isis, a common first name and name of a heavy metal band, in addition to its usage as an acronym for the Islamic State. Such keyword-based filtering algorithms will inevitably results in overblocking and false positives because of their disregard for the context in which the words are used.

Search engines also engage in this type of censorshipin 2010, I co-authored a paper [PDF] documenting how Microsoft Bing (brand new at the time) engaged in filtering of sex-related terms in the Middle East and North Africa, China, India, and several other locations by not allowing users to turn off safe search. Despite the paper and various advocacy efforts over the years, Microsoft refused to budge on thisuntil recently.

At RightsCon this year, I led a panel discussion about the censorship of sexuality online, covering a variety of topics from Facebooks prudish ideas about the female body to the UKs restrictions on non-conventional sex acts in pornography to Icelands various attempts to ban online pornography. During the panel, I also raised the issue of Microsofts long-term ban on sexual search terms in the Middle East, noting specifically that the companys blanket ban on the entire region seemed more a result of bad market research than government interference, based on the fact that a majority of countries in the MENA region do not block pornography, let alone other sexual content.

Surprisingly, not long after the conference, I did a routine check of Bing and was pleased to discover that Middle East had disappeared from the search engines location settings, replaced with Saudi Arabia. The search terms are still restricted in Saudi Arabia (likely at the request of the government), but users in other countries across the diverse region are no longer subject to Microsofts safe search. Coincidence? It's hard to say; just as we didn't know Microsoft's motivations for blacklisting sexual terms to begin with, it was no more transparent about its change of heart.

Standing up against this kind of overbroad private censorship is importantcompanies shouldnt be making decisions based on assumptions about a given market, and without transparency and accountability. Decisions to restrict content for a particular reason should be made only when legally required, and with the highest degree of transparency possible. We commend Microsoft for rectifying their error, and would like to see them continue to make their search filtering policies and practices more open and transparent.

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Goldberg: Health care’s ‘Dr. No’ – Peoria Journal Star

Posted: at 2:43 am

Jonah Goldberg

The greatest trick any politician can pull off is to get his self-interest and his principles in perfect alignment. As Thomas More observed in Robert Bolts A Man for All Seasons, If we lived in a State where virtue was profitable, common sense would make us good, and greed would make us saintly.

Which brings me to Sen. Rand Paul, the GOPs would-be Man for All Seasons. Paul emerged from the smoldering debris of the Republican health care reform train wreck as a figure of high libertarian principle, the shining no vote on any compromise that came short of full repeal.

Look, this is what we ran on for four elections, Paul told Neil Cavuto of Fox News. Republicans ran four times and won every time on repeal ObamaCare, and now theyre going to vote to keep it. Disappointing.

I found many of Pauls arguments and complaints entirely persuasive on the merits. But there have been times when I had to wonder if the merits were all that was driving him.

Was it just a coincidence that the bill was terribly unpopular in his home state of Kentucky, where more than one in five Kentuckians are on Medicaid?

This is the problem. When touting your principles is a politically expedient way of avoiding accountability, its hard to tell whether principles or expedience is in the drivers seat. But not impossible.

Paul learned politics on the knee of his father, Ron Paul, a longtime Texas congressman and irrepressible presidential candidate. In the House, the elder Paul earned the nickname Dr. No because he voted against nearly everything on the grounds that it wasnt constitutional or libertarian enough.

Im absolutely for free trade, more so than any other member of the House, he told National Reviews John Miller in 2007. But Im against managed trade.

So Paul opposed the Central American Free Trade Agreement and all other trade deals, not on Trumpian protectionist grounds but in service to his higher libertarian conscience, which, in a brilliant pas de deux, landed him in the protectionist position anyway.

Ron Paul loved earmarks. Hed cram pork for his district into must-pass spending bills like an overstuffed burrito and then vote against them in the name of purity, often boasting that he never approved an earmark or a spending bill.

In 2006, Republicans proposed legislation to slow the growth of entitlements by $40 billion over five years. Democrats, as usual, screamed bloody murder about Republican heartlessness and voted against it. And so did Ron Paul on the grounds the reform didnt go far enough. Man, that sounds familiar.

Now I cant say for sure that Rand Paul is carrying on the family tradition. He is different than his dad in many ways.

And yet: Every time health care proceedings moved one step in Pauls direction, he seemed to move one step back. Sen. Ted Cruz offered an amendment that would open up the market for more flexible and affordable plans, like Paul wanted. No good, Paul told Foxs Chris Wallace. Those plans would still be in the context of the ObamaCare mandates.

My idea always was to replace it with freedom, legalize choice, legalize inexpensive insurance, allow people to join associations to buy their insurance, Paul said.

Sounds good. Except a provision for exempting associations from ObamaCare mandates was already in the bill.

Paul insists hes sympathetic to the GOPs plight and its need to avoid a midterm catastrophe. (It would look awful if the party did nothing on health care at all.) His solution? Just repeal ObamaCare now and work on a replacement later. I still think the entire 52 of us could get together on a more narrow, clean repeal, he told Wallace.

That sounds like a constructive idea, grounded in principle.

And yet: Thats what GOP leaders wanted to do back in January. And one senator more than any other fought to stop them, and even successfully lobbied the White House to change course and do repeal-and-replace simultaneously. Guess who?

If Congress fails to vote on a replacement at the same time as repeal, Paul wrote back then, the repealers risk assuming the blame for the continued unraveling of ObamaCare. For mark my words, ObamaCare will continue to unravel and wreak havoc for years to come.

In the wake of the Senate bills collapse this week, Senate Majority Leader Mitch McConnell says hes all for a clean repeal, and so does Rand Paul. For now.

Jonah Goldberg is an editor-at-large of National Review Online. Contact him at JonahsColumn@aol.com.

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Aspen Times Weekly: How Long Do You Want to Live? – Aspen Times

Posted: at 2:42 am

Aging in Aspen is different than in other places.

Walk the malls or the streets, and you'll see people of a certain age, call it 60-plus, who glow with life. Take to the steep roads or trails just after dawn and you will be passed by geriatric joggers and cyclists, mixed in with the millennials and Gen-Xers, riding or running up the substantial hills, getting miles in before breakfast.

Aspenites of all ages embrace their physicality. They are in shape and they are either living the later years of their lives to the fullest, on their own terms, or actively pursuing healthy practices so that their futures will also be bright.

At a plethora of events like last week's Aspen Brain Lab and the Aspen Institute's Spotlight Health, presented earlier this summer, Aspenites engage with each other and with new, sometimes revolutionary ideas in health care. Make no mistake, the outsized financial resources of the community allow many to benefit from the best health care that money can buy.

Human Longevitys intentions, if successful, would transform the status quo of the medical, pharmaceutical and health insurance industries.

Let's face it, this is an amazing place to grow old.

A POTENTIALLY NEW PARADIGM

Last week, in a lovely private home at the base of Smuggler Mountain, a small group of Aspenites gathered to hear of a budding revolution in health care. As the assembled, ranging in age from late 30s to their mid 70s, relaxed in chairs and on sofas in the well-appointed living room, sipping wine and sampling spring rolls, they listened to a presentation that proposed the potential to change the way they look at their own health. And their future, as well.

While the first nourishing rain in months pelted the roof and shrouded the Aspen Mountain views from the house, J. Craig Venter, who gained fame, acclaim and fortune in the early 2000s for his role in the quest to sequence the human genome, explained how his latest creation, Human Longevity, Inc., in La Jolla, California, is working to turn the world of health care upside down.

Venter, a vibrant 70-year-old, co-founded Human Longevity to provide people with the most complete and intensive genetic and physical assessments of their health that has ever existed. These "road maps" show clients, in intimate detail, the exact condition of their bodies at a given moment in time, and what pitfalls may exist for the future based upon their genetic makeup.

Sitting comfortably with his toy poodle, Darwin, on his lap, the bearded Venter detailed his vision for the company that has raised over $300 million in capital from investors, including Celgene and GE Ventures. The goal is to give people, and eventually health care companies, advance information about pre-existing health issues so that the focus can be on prevention as a health care option, rather than continuing the long entrenched tradition of "fixing" people after they have already developed maladies or life threatening diseases.

Perhaps because of Venter's earlier success with the human genome, his project is receiving much attention. Last year he was here in Aspen to address the Ideas Festival and speak at the Charlie Rose Weekend event. This spring he was the subject of a Forbes Magazine cover story on the project and has also been featured in documentaries produced by production companies as disparate as NOVA and Red Bull TV. Though he is not without his detractors, some of whom find him arrogant and infused with an outsized disrespect for established medical conventions, Venter is once again on a quest for change.

Like Amazon revolutionizing shopping, Tesla challenging the automotive industry and Uber disrupting transportation, Human Longevity's intentions, if successful, would transform the status quo of the medical, pharmaceutical and health insurance industries.

THE HEALTH NUCLEUS PROGRAM

The product of the Human Longevity is knowledge on a disk.

Clients currently come to a luxurious facility in La Jolla for a physical assessment unlike any that has previously been available to human beings. Called the Health Nucleus, the procedure calls for a complete review and analysis of a client's physical health. When completed, clients walk away with a disk that details both their DNA and their current state of health.

The first element of the Health Nucleus, and perhaps most revolutionary, is the process of a whole genome sequencing of each client, the actual mapping of their personal genetic code, or their DNA. Every cell of a person has 23 pairs of chromosomes. In each chromosome there are millions of pieces of information. Think of these as individual words or letters that are unique to any and every individual. This is the genetic story of our lives. "Add it all up and there are 6.4 billion characters of code in each of us," Venter said.

This data tells us everything about our physical makeup. The color of our eyes and hair, how tall we will grow, whether we are right-handed or left-handed. And it also tells us what diseases we may be susceptible to, or even pre-ordained for. From cancers to cardiovascular issues, which combined account for two-thirds of all deaths in this country, to metabolic and neurological issues, the genome sequencing provides insights into what potential health issues we should be aware of.

At the completion of the whole genome sequencing, the information is analyzed and cross-referenced with the largest database of full genotypic information that currently exists. A 500-page report is prepared, including with a short summation, for each client. "When we did the first genome sequencing in 2000 we built a $50 million computer and the cost of the process was $100 million. Today, thanks to the progress in computing power, we are able to do a sequence in 12 minutes at a cost of closer to $1,000," Venter said to the intrigued group. "The computing power we have today is 1,350 times greater than when we first started sequencing the genome."

The second component of the Health Nucleus is a full body and brain Magnetic Resonance Imaging, or MRI. This state of the art technology uses high frequency radio waves to produce vivid, vibrant and previously unimaginably clear images of internal organs. And, in contrast to previous technologies like cat scans, it requires no radiation.

This MRI will show, with a multitude of cross sections, what is inside your body and the state of health it is in. Ever want to see the size of your hippocampus in full Technicolor? How about your kidney in 3-D? At the conclusion of the session, as many as 18,000 images of the client's body can be accessed.

These exams are not just for the aged. In fact, the ability for the Health Nucleus examinations to offer a base line of health information can change the way younger people plan for their health care throughout their lives. "We have performed assessments on people from 18 to 99 years old," Venter said. He recommended that the procedures are appropriate for people, beginning in their 20s and 30s.

REAL LIFE MEANING

But beyond just the novelty and wonder of seeing what the inside of your body looks like, the MRI has the capability of identifying real life-threatening issues that may go undetected in other types of physicals. "Forty percent of the people who undergo the assessments have something to address. Two-and-a-half percent who come in have cancers," Venter said. "We see lots of aneurysms that are treatable and incidents of prostate cancers in men."

"Early detections are extremely rewarding," Venter said with a degree of irony, before explaining his own experience with the assessments. "Last year I underwent a physical with my doctor and showed no indications of any issues. I then went through our Health Nucleus assessment and discovered, to my shock, that I had high-grade prostate cancer." After undergoing treatment last November, Venter is now cancer free.

Choking up in front of the group, Venter also told the story of his science mentor, partner and friend, Nobel laureate in medicine Hamilton Smith, 85, who found he had a deadly lymphoma while undergoing an evaluation using the Health Nucleus assessment. He, too, underwent treatment and is doing well. "Ham would likely not be alive today if we had not begun this project."

The Health Nucleus project is still in its development stages and there are issues to be reckoned with. Colon cancers, for example, cannot be identified reliably as of yet, so colonoscopies are still recommended. Stat News, an online health journalism site produced by Boston Globe Media, recently presented an article stating that there are components of the human genome that have yet to be decoded that could affect the accuracy of current sequencing. Finding physicians who have the capability to review the data properly can be a challenge. And the costs of the Health Nucleus screenings are not currently covered by insurance and must be paid out of pocket.

But Venter is aggressively moving forward. It was announced that Human Longevity will be opening 10 new clinics throughout the nation; unfortunately Aspen is not currently on the docket. And perhaps most importantly, HLI has introduced two new versions of its consumer assessments at price points of $4,900 or $7,500, considerably less than the original Health Nucleus Platinum program that costs $25,000. Expectations are those costs will come down in the future as the program scales up.

While immortality may never be an option, increasing one's life span by a number of years by predicting and preventing treatable disease may well be the wave of the future. When I asked J. Craig Venter how long he wants to live, he looked wistfully across the room toward his wife, Heather. "Well, I'd like to see this project through," he said with a stiff upper lip. Then, in a much softer voice, "And I'd like to spend as much time with my wife as I possibly can."

For those who can afford it and are interested in knowing as much about their health options as is possible, and potentially reducing the onset of preventable disease, the Health Nucleus testing may be very attractive. As Aspenite Joe Nevin, who hosted the gathering, asked, "Why wouldn't you want to know?"

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Aspen Times Weekly: How Long Do You Want to Live? - Aspen Times

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