Daily Archives: July 5, 2017

Hackers who targeted Ukraine clean out bitcoin ransom wallet – The Guardian

Posted: July 5, 2017 at 8:50 am

transferred to a second wallet on Tuesday night. Photograph: Bloomberg/Bloomberg via Getty Images

The hackers behind the NotPetya ransomware, which wiped computers in more than 60 countries in late June, have moved more than 8,000 worth of bitcoins out of the account used to receive the ransoms.

The transfer has added credence to messages purporting to be from the attackers offering to decrypt every single infected computer for a one-off payment of 200,000, after security researchers suggested they may be state-sponsored actors.

It is possible to see the movement of the ransom payments thanks to the public nature of the bitcoin currency: all transfers are recorded on the public blockchain, although the real-world identities of the individuals or organisations behind a particular payment address can be near-impossible to discern.

Currently, the blockchain records that the bulk of the ransom money, 7,872 worth of bitcoin, was simply transferred to a second wallet on Tuesday night, but two smaller payments, of 200 each, went to accounts used by two text-sharing websites, Pastebin and DeepPaste.

Around 10 minutes before the payments were made, someone made posts on both those sites claiming to be able to decrypt hard disks infected with the malware in exchange for a payment of 100 bitcoins.

The 200,000 offer has created more uncertainty about the motivations behind the ransomware. While it originally appeared to be created with the intention of earning a lot of money through ransom payments, researchers quickly pointed out that a number of features of the software made it appear that the ransom element was a smokescreen, with the real goal being widespread damage.

Significantly, the majority of infections occurred in Ukraine, due to the main attack vector being a compromised version of an accounting program, ME Doc, used to file taxes in the nation. That has led to many, including the Ukrainian government, suspecting Russian involvement as part of the ongoing cyberwar between the two countries.

Hackers offering to decrypt files for money suggests that the cash motivation may be more significant than thought but that too could be misdirection.

While the hackers continue to play games, the Ukrainian cybercrime unit is continuing its investigation. On Wednesday, it announced that it had seized ME Docs servers after new activity was detected there, and said it had acted to immediately stop the uncontrolled proliferation of malware.

Cyber police spokeswoman Yulia Kvitko suggested that ME Doc had sent or was preparing to send a new update and added that swift action had prevented any further damage. Our experts stopped (it) on time, she said.

It wasnt immediately clear how or why hackers might still have access to ME Docs servers. The company has not returned messages from reporters, but in several statements took to Facebook to dispute allegations that its poor security helped seed the malware epidemic.

Cyber police chief Coonel Serhiy Demydiuk previously said that ME Docs owners would be brought to justice, but Kvitko said there had been no arrests.

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Goldman Sachs says bitcoin could rise another 50% – CNBC

Posted: at 8:50 am

Goldman Sachs is out with a call on bitcoin, and chart analyst Sheba Jafari expects the digital currency could rise as high as $3,915.

That would be 52 percent above Monday's price of about $2,567.

"The market is in wave [four] of a sequence that started in the late-'10/early-'11 lows," Jafari wrote in a Sunday report on charts for the week ahead. We are "eventually expecting one more leg higher; a 5th wave."

"From current levels, this has a minimum target that goes out to 3,212 (if equal to the length of wave I)," Jafari said. "There's potential to extend as far as 3,915 (if 1.618 times the length of wave I). It just might take time to get there."

Bitcoin three-month performance

Source: CoinDesk

Bitcoin has traded in a range between about $2,100 and $3,000 ever since hitting a record high of $3,025.47 on June 11, according to CoinDesk.

Uncertainty about the future of bitcoin itself has kept prices in check lately. Updates to the bitcoin network scheduled for release in the next several weeks could split the digital currency in two if developers don't agree on how to make the updates compatible with each other.

To be sure, Jafari said, "fourth waves tend to be messy/complex," meaning bitcoin could continue trading in a range and potentially fall close to $1,857 before recovering.

On June 12, Jafari said in a note written "due to popular demand" that she was "wary of a near-term top ahead of $3,134." She said traders should "consider re-establishing bullish exposure between $2,330 and no lower than $1,915."

After topping $3,000 for the first time on June 11, bitcoin prices fell more than $800 to a low of $2,185.96 less than a week later. However, bitcoin recovered to end the month at $2,499.98, up 7.2 percent for June and having risen 158 percent for the year so far.

The Goldman reports illustrate how mainstream Wall Street is paying much closer attention to bitcoin, despite high volatility and lack of regulation in the digital currency world. This week, bitcoin and the blockchain technology behind it made the cover of a well-respected investing magazine, Barron's.

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Can Bitcoin And Ether Prices Materially Affect NVDA And AMD Stocks? – Seeking Alpha

Posted: at 8:50 am

By now most of you probably know what cryptocurrencies are. This year, their prices have been soaring to say the least. The most popular cryptocurrencies nowadays are Bitcoin and Ether. I am not going to describe the specifics of cryptocurrencies, but rather show you how much of the "cryptocurrency effect" there is in the prices of two specific stocks, Advanced Micro Devices (AMD) and Nvidia (NVDA). It is important for investor to be aware of it, because it could strongly impact the future behaviour of these two stocks.

AMD and NVDA both produce graphic cards that are broadly used for gaming purposes. Lately, however, they have been sold like hotcakes for the purposes of crypto mining. Cryptocurrency mining is a process of acquiring cryptocurrencies like Bitcoin or Ether. To put it simply, for mining cryptocurrencies yourself you need a computer, internet, electricity and a good graphic card. Consequently, you need an NVDA or an AMD graphic card.

The total market capitalization of cryptocurrencies has grown substantially in 2017. It now stands at more than $100 billion. For comparison, that is just a little more than the joined market capitalization of NVDA and AMD, which stands at around $98 billion.

Total market capitalization of cryptocurrencies:

Source: coinmarketcap.com

The stocks of both companies have been soaring as well. The reports have been stating that this is partly due to the soaring of the cryptocurrency prices. Therefore, lets have a closer look at the comparison between prices of these two stocks and the prices of Bitcoin and Ether.

Firstly, let me state that in this article I am not going to assess, how the sales of graphic cards to the crypto mining community are affecting the fundamentals of the companies. Instead, I will present how much the price fluctuations of these crypto assets affect the price fluctuations of NVDA and AMD stock.

For a better understanding, a correlation value of 1 represents a perfect positive correlation (moving in sync) and a correlation of -1 represents a perfect negative correlation. Because the prices of cryptocurrencies started soaring in 2017, I divided the calculation periods in two segments. The 1st period shows the correlation from 30.6.2016 until the end of 2016 and the 2nd period shows the correlation from the beginning of 2017 until 30.6.2017.

Advanced Micro Devices (AMD)

Lets have a look at AMD stock performance and the performance of the most popular cryptocurrencies, Bitcoin and Ether. From the reports, one would presume that there would be some noticeable correlation between the stock performance of AMD and the prices of Bitcoin or Ether. When looking at the actual results that is not however the case.

AMD/Bitcoin

Correlation

30.6.2016 the end of 2016

0.755

Beginning of 2017 30.6.2017

-0.115

Source: own calculations

The correlation between AMD and Bitcoin in the 1st period is 0.75. Such a figure represents a relatively strong correlation. Nonetheless, if we look at the correlation between AMD and Bitcoin in the 2nd period the value is -0.115. That shows a very small negative correlation between these two assets. Thus, from the results the correlation between AMD and Bitcoin stopped at the beginning of 2017, when AMD ceased to follow the rapid growth of Bitcoin.

AMD/Ether

Correlation

From 30.6 - end 2016

-0.763

Start 2017 - till 30.6.2017

-0.09

Source: own calculations

If we compare that with AMDs correlation to Ether, it shows a completely different picture. The correlation in the 1st period was -0.763, which is a high negative correlation. Ethers price in 2016 was still a single digit number, especially in the second half of the year when it was not performing well at all. The correlation in 2017 changed to -0.09. This means that the correlation in this period was almost non-existent. When observing each asset individually, we can see that the main reason for this was an immense increase in Ethers price by more than a factor of 30 in 2017 (moving from $8-10$ to more than $300). Yet, the price of AMD stayed more or less flat in the same period.

Summary for AMD

It is true that a lot of demand for AMDs graphic cards is currently coming from the crypto mining community. Nevertheless, if we look at the correlation data we can say that specifically for 2017 there is no firm price performance correlation when comparing AMD to Bitcoin or Ether.

We can conclude that AMD investors, who are thinking that Bitcoin and Ether are in a bubbly territory, can be a bit calmer. Even if there is a bubble in the crypto space and it bursts, according to the correlation AMDs stock would not follow the potential steep downward move. For those investors, who want to own AMD for the sole purpose of obtaining direct exposure to the crypto space this is probably not the best idea when looking at the correlation.

Nvidia

If we now look at the same situation for NVDA we can detect a different pattern. The correlation between NVDA and Bitcoin in the 1st period stood at 0.834, which is a higher value than for AMD and shows a stronger bond between these assets. Even more interesting is the correlation in 2017. It stands at a whooping 0.911. That is definitely a big difference when comparing it to AMD. Such a strong correlation could be a big surprise for NVDAs investors.

NVDA/Bitcoin

Correlation

From 30.6 - end 2016

0.834

Start 2017 - till 30.6.2017

0.911

Source: own calculations

The correlation with Ether shows a similar picture in the 1st period, where it stood at -0.769. However, a noticeable difference is shown in 2017. The correlation in 2017 between NVDA and Ether stands at 0.904, comparable with the NVDA/Bitcoin correlation.

NVDA/Ether

Correlation

From 30.6 - end 2016

-0.769

Start 2017 - till 30.6.2017

0.904

Source: own calculations

Summary for NVDA

This correlation values, especially the ones in 2017, show a strong tie between the performance of NVDA and these two cryptocurrencies. Investors should thus take into account the correlation when investing in NVDA. If the prices of Bitcoin or Ether falls sharply NVDA could follow as well. So, if you are an investor or thinking of investing in NVDA you should probably keep an eye on the prices of cryptocurrencies.

Then again, for investors, who are bullish on cryptocurrencies, this could represent an interesting alternative, of course, depending on the correlations staying at these levels in the future.

Conclusion

We cannot deny the effects of higher Bitcoin and Ether prices on increased interest in mining these currencies. Consequently, there is an increased demand for AMDs and NVDAs graphic cards. On one hand, this segment represents only a fraction of the revenues these two companies make, so looking from the fundamental perspective it is not so meaningful. However, on the other hand, correlation numbers show that in some cases this is substantially affecting the stock prices.

More importantly, due to the big rally these stocks have had in the last months, one needs to be aware of the potential crypto currency effect in them.

In conclusion NVDAs investors need to be prepared for a potential volatile ride, while AMDs can be calmer.

But as we all know current stock prices can on the short horizon tell one thing and fundamentals another. Investors, keep that in mind!

Calculations: The correlation is calculated using the Pearson product-moment correlation coefficient.

Disclosure: I/we have no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours.

I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.

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Phoenix Neurologist is Charged With Selling Bitcoin Without a License – Reason (blog)

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When the U.S Treasury Department declared in March 2013 that exchangers and administrators of virtual currencies like Bitcoin were "money service businesses" subject to regulation under the Bank Secrecy Act, Reason's Brian Doherty issued a prescient warning.

"What the government cannot stop (and ought not try to stop) it can still interfere with, and ruin lives in the process," he wrote that May. "Those who think it necessary that Bitcoin be regulated, even if they want to be in on making the regulations as sane and harmless as possible, need to remember that every regulation has a punishment attached for violating it."

On Friday, the Treasury's Financial Crimes Enforcement Network charged Phoenix-area neurologist Peter Steinmetz with operating an unlicensed bitcoin exchange.

FinCEN alleges that Steinmetz, along with co-defendant Thomas Costanzo, "enabled their customers to exchange cash for 'virtual currencies' charging a fee for their service" without a federal or state money transmitting license in violation of the Bank Secrecy Act.

Costanzo, whose internet alias is Morpheus Titania, established a localbitcoins.com account to conduct in-person exchanges of cash for bitcoin a month after FinCEN made such exchanges without a money transmitters license a crime, according to the indictment.

While Steinmetz and Costanzo's business failed to attract federal attention for several years, Steinmetz had received $10,000 in Bitcoin funding from an anonymous donor to continue his work researching memory for the Arizona-based Barrow Neurological Institute (BNI).

"It's almost appropriate actually, that a cutting-edge method of funding is used to fund cutting-edge research," he told the Arizona Republic at the time of the donation.

A month later security arrested Steinmetz for carrying a loaded AR-15 into the Phoenix Sky Harbor airport as a protest against the TSA. BNI cut ties with him soon after.

Undercover federal agents in 2015 initiated a series of transactions with Costanzo, paying him roughly $160,000 in cash in exchange for bitcoin over two years. Agents arrested Costanzo on April 20 and got an indictment issued for Steinmetz two months later.

The indictment does not make clear what role Steinmetz played in the bitcoin-for-cash business.

Several men have already been convicted of similar offenses. In April, a New York man pleaded guilty to operating an unlicensed money transmitting business after an undercover federal agent paid him $37,000 for 37 Bitcoins. In May, Missouri tech entrepreneur Jason Klein pleaded guilty to the same crime after making several in-person cash-for-bitcoin transfers with an undercover federal agent.

There has been some legal pushback to these prosecutions.

In 2016, Florida State Circuit Judge Teresa Pooler dismissed state-level charges against Michell Espinoza for selling $1,500 worth of bitcoin to an undercover cop he met via localbitcoins.com, ruling that bitcoin did not count as a "payment instrument" under Florida law.

"Attempting to fit the sale of Bitcoin into a statutory scheme regulating money services businesses is like fitting a square peg in a round hole," Pooler wrote at the time.

Pooler's interpretation of a Florida statute is unlikely to help Steinmetz.

Making the square bitcoin peg fit into the round financial regulation hole could mean as much as five years in prison for Steinmetz. An associated conspiracy charge could cost him even more.

If convicted, Steinmetz could join the "ruined lives" of which Doherty warned.

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Bitcoin spurs graphic card shortage – Bangkok Post

Posted: at 8:50 am

At Commart Joy recently, many of the visitors flocked to the graphic card booth.

The rising popularity of bitcoin has caused a shortage in supply of graphic cards, the main component of the cryptocurrency system, over the past couple of years, according to an executive in the gaming industry.

The value of graphic cards has also been increasing sharply since mid-May, said Somyot Chaowalit, chief executive of JIB Computer Group, a leading computer gaming and IT retail chain.

Graphic cards are a key component of computer systems used for mining the digital currency bitcoin. Users can get returns on their investment from bitcoin faster than other types of investment -- within only five to 15 months.

According to Mr Somyot, some people consider investing in a mining rig -- a computer system used for mining bitcoin -- not very risky. They use at least six graphic cards, at a cost of around 100,000 baht, for a mining rig.

The margin on graphic cards has been growing since the second quarter this year, from 2-3% to 8-10%. However the company needs to reserve the cards to avoid a negative impact on gamers.

Demand for graphic cards is also high in the gaming market.

Meanwhile, graphic card makers recently introduced lower-price graphic cards for bitcoin as they don't come with a display port.

The price is 20% lower than the regular cards, with shorter warranty periods, at three to six months instead of three years.

Mr Somyot said half of JIB's revenue comes from mid- to high-end computers, particularly tailor-made gaming computers, with prices starting from 25,000 baht for a gaming desktop and 40,000 baht for a gaming notebook.

He said this year its revenue is expected to grow 20% compared to an earlier forecast of 15%, reaching 8.2 billion baht.

The company aims to garner 10 billion in revenue by 2018 from the growth of the gaming industry and bitcoin use.

Chukkrit Watcharasaksilp, chief executive of Advice Holding Group, a leading IT chain, said bitcoin's popularity rebounded in Thailand this May after it was first introduced here three years ago.

The most popular graphic cards used for bitcoin are AMD 570 and 580 and NVIDIA 1060 and 1070, which were in short supply, causing a 20% price hike.

The higher prices are predicted to remain until October.

Jarit Sidhu, research manager at IDC's Asia/Pacific, said bitcoin is now accepted in many countries such as Japan, China, Australia, Russia and the US. The price of bitcoin valuation can swing by 30%, he said.

"We have never seen such a long queue of visitors at the computer exhibition as last month at Commart," said Mr Jarit. The computer market has been declining for nearly a decade, he said.

Don Sambandaraksa, a long-time bitcoin enthusiast who has been associated with digital currency since 2013 when bitcoin was priced at US$40, said these days bitcoin can no longer be effectively mined with central processing units or even graphics processing units.

People have created chips that can only do bitcoin hashes and nothing else, he said.

A 1080Ti card costs about $700 and can gain a return on investment (ROI) in some 108 days, said Mr Don. Over a year, it can make $2,300, an annual ROI of about 300%.

As more people flock to buy graphic cards, the less profitable they will be, he said. But it is an indication of the crazy levels of profitability that mining offers, said Mr Don.

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How Living on Mars Could Challenge Colonists (Infographic)

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Conditions make living on the red planet extremely challenging.

With half the diameter of Earth, Mars has much lighter gravity (one-third of Earth norm) and a much thinner atmosphere. Humans cannot survive unaided on its surface.

The air on Mars, such as it is, is about 1 percent the density of air on Earth. Martian air is composed of more than 95 percent carbon dioxide. Since Mars lacks a substantial magnetic field like the Earth's, the Red Planet cannot deflect harmful radiation that comes from space.

It's also much colder on Mars than on the Earth. On Mars, the average temperature is about 210 Kelvin, or about minus 81 degrees Fahrenheit (minus 64 degrees Celsius). On Earth, however, the average temperature of the planet as a whole is about 290 Kelvin, or 62 degrees F (16.8 C).

Mars has two tiny potato-shaped moons, Phobos and Deimos. They are 14 miles (22.5 kilometers) and 8 miles (13 km) across, respectively.

Colonists on Mars may need to draw up a new kind of clock or calendar. A days on Mars - scientists call them "sols" - are slightly longer than Earth days. One Martian sol is about 24.63 hours, while an Earth day clocks in at 23.94 hours.

The Martian year is also longer than that of the Earth because it takes Mars longer to orbit the sun. One year on Mars lasts 687 days, compared to Earth's 365 days.

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Startling revelation of how Christianity was in already in Africa before colonization – GhanaWeb

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Feature Article of Tuesday, 4 July 2017

Columnist: King David Dzirasah

It cannot be said that Christianity is a colonial relic or symbolism of slavery

Jerusalem long lost or not, Christianity is Afro-orient, not European. Christianity was thriving in the horn of Africa in the 1st century before this religion had really taken root anywhere in Europe. Akinyi Princess of KOrinda Yimbo.

Most often both academic and non-intellectuals based on historical understanding conclude that Europeans brought or introduced Christianity to Africa. It is often said that missionaries from Europe during the colonial days came down from Europe to Africa in their quest of spreading Christianity on a dark continent that is heading towards hell. However, there is ample evidence suggesting that Christianity was already on the continent before the advent of colonization and the coming of European missionaries.

The Coptic orthodox church of Alexandria is an oriental orthodox Christian church in Egypt, northeast Africa and Middle East. The Egyptian church is traditionally believed to be founded by Saint Mark at around AD 42. Christianity spread throughout Egypt within half a century of Saint Marks arrival. Christianity being introduced to the horn of Africa clearly is not as a result of missionary work of Europeans. Even though Christianity was able to spread from the northern part of Africa to the eastern part (Ethiopia), the complete spread of the religion to all part of the continent was made impossible due to the advancement of Islam in the northern part of the continent.

It is recognizable that historically Christianity came to Sub-Sahara Africa in the 15th century but that cannot over shadow the fact that Christianity was already on the continent before the coming of colonial imperialist. As of the 7th to 8th century, African warriors were fighting in Europe under the banner of the lion and the half-moon in order to bring the truth faith, Christianity or Islam, to Europe.

Europeans at the time were in the majority heathen and did everything in their power to remain heathen. Because Christ came from their corner of the world, Africans had embraced Christianity at a time when the religion was struggling to take root in Greece and Rome. Princess of Korinda-Yimbo. Historically Jesus was actually taken to the northern part of Africa (Egypt) as a child. With that link to that part of the continent, the people were accommodating to the missionary work of Saint Mark.

The biblical Ark of the Covenant is now believed to be kept in St Mary of Zions Church in Axum, Ethiopia. With the knowledge in mind that Africans actually play a crucial role in the expansion of the religion in Europe, one cannot make the assertion that Europeans actually introduced Africans to the religion. It cannot be said that Christianity is a colonial relic or symbolism of slavery since evidentially the existence of the religion precede colonization.

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‘Woolly’ Breathes New Life Into A Scientific Saga – NPR

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In the winter of 1990, George Church and Ting Wu he resplendent in his bushy beard, she wearing a skirt, which she rarely did rode their bicycles to city hall in Cambridge, Mass., to be wed. For years they kept their marriage an open secret, and that relationship would have ramifications, both positive and otherwise, for their careers: They worked together in a Harvard lab, trying to unlock the secrets of DNA.

Ben Mezrich's new book, Woolly, is about science's attempt in recent years to use genetic engineering to revive the extinct woolly mammoth. But as with his previous bestselling works of narrative nonfiction such as Bringing Down the House, the basis of the film 21, and The Accidental Billionaires, the basis of the film The Social Network Woolly dwells on close-ups before zooming out to the big picture.

Church and Wu are two of the main characters in Mezrich's taut yet detailed dramatization. Theirs is a synergistic relationship, and while it would be an overreach to call Woolly a love story at heart, the couple's dynamic is one of the essential threads of Mezrich's story. By all accounts geniuses, the two form the nucleus of a group of Harvard scientists whose revolutionary research leads them to a staggering conclusion: They must use their knowledge and abilities to manipulate the genome of Mammuthus primigenius, the hairy pachyderm that perished from the face of the earth over 3,000 years ago.

Their reasons, as Mezrich spells out, are more than academic. By pioneering the methods it would take to clone a mammoth and gestate the fetus successfully in the womb of an elephant, Church, Wu, and crew would open the door to further efforts to revive extinct species and, through the impact these reintroduced species would have on the environment, to help reverse the damages that modern civilization has had on Earth's ecosystem and climate.

The Harvard group isn't the only one working toward this end. In Russia, the father-son team of Sergey and Nikita Zimov launch Pleistocene Park, a wildlife preserve on the steppes of Siberia, where the mammoth once freely roamed and where they could possibly roam once more.

It all sounds very Jurassic Park, of course, and Mezrich doesn't hesitate to draw that parallel. The hubris of such scientific endeavors, as well as the ethical issues involved, crop up in Woolly, although it's clear the author's sympathies lie with his subjects. Anecdotes like the wedding of Church and Wu form the backbone of the book, rather than serving as ornament. Mezrich's eye for characterization is as sharp as his ability to break down scientific jargon into easily digestible chunks.

The true protagonists of Mezrich's saga, though, are the great mammoths themselves. Through his fluid use of close perspective, poetic license, and present-tense recreations of past events not to mention his occasional speculation into the future the author dramatically illustrates his tale. It's paced like a thriller, with the frustrating politics of the research industry bleeding over into the maneuverings of capitalists who see dollar signs in investing in widespread genetic engineering. Mezrich also frequently reconstructs dialogue between the plot's players, which at times feels overly contrived and distracting.

Thankfully it's not enough to inhibit the intimate look into the lives of the men and women who are humbly and at time not so humbly hoping to put the power of creation at their fingertips. With all the passion and vision of the scientists seeking to bring the mammoth back to life, Woolly reanimates history and breathes new life into the narrative of nature.

Jason Heller is a senior writer at The A.V. Club, a Hugo Award-winning editor and author of the novel Taft 2012.

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Genetics causing arthritis possibly helped humans survive Ice Age – The Indian Express

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By: IANS | New York | Published:July 4, 2017 10:51 pm Mutations in the gene called GDF5 resulted in shorter bones that led to a compact body structure while reducing the risk of bone fracture from falling. Thus, it also favoured early humans to better withstand frostbite. (Source: File photo)

A genetic change associated with shorter stature and increased risk of arthritis might have helped our ancestors survive the Ice Age, a study has showed. The findings showed that mutations in the gene called GDF5 resulted in shorter bones that led to a compact body structure while reducing the risk of bone fracture from falling. Thus, it also favoured early humans to better withstand frostbite as well as helped them migrate from Africa to colder northern climates between 50,000 and 100,000 years ago.

These advantages in dealing with chilly temperatures and icy surfaces may have outweighed the threat of osteoarthritis, which usually occurs after a prime reproductive age, the researchers said. The variant that decreases height is lowering the activity of GDF5 in the growth plates of the bone.

Interestingly, the region that harbours this variant is closely linked to other mutations that affect GDF5 activity in the joints, increasing the risk of osteoarthritis in the knee and hip, said Terence Capellini, Associate Professor at the Harvard University. For the study, published in the journal Nature, the team examined gene GDF5 first linked to skeletal growth in the early 1990s to learn more about how the DNA sequences surrounding GDF5 might affect the genes expression.

They identified a single nucleotide change that is highly prevalent in Europeans and Asians but rarely occurs in Africans. Introducing this nucleotide change into laboratory mice revealed that it decreased the activity of GDF5 in the growth plates of the long bones of foetal mice. The potential medical impact of the finding is very interesting because so many people are affected, said David Kingsley, Professor at the Stanford University.

This is an incredibly prevalent, and ancient, variant. Many people think of osteoarthritis as a kind of wear-and-tear disease, but theres clearly a genetic component at work here as well. Now weve shown that positive evolutionary selection has given rise to one of the most common height variants and arthritis risk factors known in human populations, Kingsley said.

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Genetics causing arthritis possibly helped humans survive Ice Age - The Indian Express

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$10 million gift launches joint Harvard, Children’s Hospital brain center – The Boston Globe

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By Felice J. Freyer Globe Staff July 04, 2017

How did the human brain develop skills far beyond those of any other primate? Which genes enabled language, science, and art?

Those are some of the central questions facing the newly created Allen Discovery Center for Human Brain Evolution, a joint initiative of Boston Childrens Hospital and Harvard Medical School.

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The Paul G. Allen Frontiers Group , a Seattle-based funder of scientific research, announced Wednesday that it is awarding $10 million over four years to launch the center.

The Allen Discovery Center will bring together researchers in neuronal molecular biology, human evolution, genetics, and genomics to figure out what exactly makes humans unique which genes were involved, when they came into play, and how they were affected by experience and environment.

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Its just amazing to try to contemplate how humans developed with all the unique capacities that we have, said Dr. Christopher A. Walsh, chief of the Division of Genetics and Genomics at Boston Childrens Hospital and the centers leader.

The grant, he said, forces interactions between people doing very good work in their own separate areas.

For example, Walshs team at Childrens identified the genetic cause of a rare condition that results in babies born with tiny brains. The condition occurs when a certain gene is disabled. Could that gene have been responsible for the development of humans larger brains? Maybe nature boosted its function as a way of making the brains of our human ancestors get bigger, he said.

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The Allen Discovery Center will make it easier for Walsh to answer that question by teaming up with center co-leader David E. Reich, a Harvard Medical School genetics professor, who studies the evolution of populations.

Michael Greenberg, a Harvard neurobiologist and also a center co-leader, said in a statement that the Allen grant would enable three laboratories that have been working independently to come together and study the genetic, molecular, and evolutionary forces that have given rise to the spectacular capacities of the human brain.

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