The Prometheus League
Breaking News and Updates
- Abolition Of Work
- Ai
- Alt-right
- Alternative Medicine
- Antifa
- Artificial General Intelligence
- Artificial Intelligence
- Artificial Super Intelligence
- Ascension
- Astronomy
- Atheism
- Atheist
- Atlas Shrugged
- Automation
- Ayn Rand
- Bahamas
- Bankruptcy
- Basic Income Guarantee
- Big Tech
- Bitcoin
- Black Lives Matter
- Blackjack
- Boca Chica Texas
- Brexit
- Caribbean
- Casino
- Casino Affiliate
- Cbd Oil
- Censorship
- Cf
- Chess Engines
- Childfree
- Cloning
- Cloud Computing
- Conscious Evolution
- Corona Virus
- Cosmic Heaven
- Covid-19
- Cryonics
- Cryptocurrency
- Cyberpunk
- Darwinism
- Democrat
- Designer Babies
- DNA
- Donald Trump
- Eczema
- Elon Musk
- Entheogens
- Ethical Egoism
- Eugenic Concepts
- Eugenics
- Euthanasia
- Evolution
- Extropian
- Extropianism
- Extropy
- Fake News
- Federalism
- Federalist
- Fifth Amendment
- Fifth Amendment
- Financial Independence
- First Amendment
- Fiscal Freedom
- Food Supplements
- Fourth Amendment
- Fourth Amendment
- Free Speech
- Freedom
- Freedom of Speech
- Futurism
- Futurist
- Gambling
- Gene Medicine
- Genetic Engineering
- Genome
- Germ Warfare
- Golden Rule
- Government Oppression
- Hedonism
- High Seas
- History
- Hubble Telescope
- Human Genetic Engineering
- Human Genetics
- Human Immortality
- Human Longevity
- Illuminati
- Immortality
- Immortality Medicine
- Intentional Communities
- Jacinda Ardern
- Jitsi
- Jordan Peterson
- Las Vegas
- Liberal
- Libertarian
- Libertarianism
- Liberty
- Life Extension
- Macau
- Marie Byrd Land
- Mars
- Mars Colonization
- Mars Colony
- Memetics
- Micronations
- Mind Uploading
- Minerva Reefs
- Modern Satanism
- Moon Colonization
- Nanotech
- National Vanguard
- NATO
- Neo-eugenics
- Neurohacking
- Neurotechnology
- New Utopia
- New Zealand
- Nihilism
- Nootropics
- NSA
- Oceania
- Offshore
- Olympics
- Online Casino
- Online Gambling
- Pantheism
- Personal Empowerment
- Poker
- Political Correctness
- Politically Incorrect
- Polygamy
- Populism
- Post Human
- Post Humanism
- Posthuman
- Posthumanism
- Private Islands
- Progress
- Proud Boys
- Psoriasis
- Psychedelics
- Putin
- Quantum Computing
- Quantum Physics
- Rationalism
- Republican
- Resource Based Economy
- Robotics
- Rockall
- Ron Paul
- Roulette
- Russia
- Sealand
- Seasteading
- Second Amendment
- Second Amendment
- Seychelles
- Singularitarianism
- Singularity
- Socio-economic Collapse
- Space Exploration
- Space Station
- Space Travel
- Spacex
- Sports Betting
- Sportsbook
- Superintelligence
- Survivalism
- Talmud
- Technology
- Teilhard De Charden
- Terraforming Mars
- The Singularity
- Tms
- Tor Browser
- Trance
- Transhuman
- Transhuman News
- Transhumanism
- Transhumanist
- Transtopian
- Transtopianism
- Ukraine
- Uncategorized
- Vaping
- Victimless Crimes
- Virtual Reality
- Wage Slavery
- War On Drugs
- Waveland
- Ww3
- Yahoo
- Zeitgeist Movement
-
Prometheism
-
Forbidden Fruit
-
The Evolutionary Perspective
Monthly Archives: June 2017
IMF Urges Banks to Invest In Cryptocurrencies – Investopedia
Posted: June 27, 2017 at 6:51 am
A June 2017 staff discussion note from the International Monetary Fund (IMF) suggests that banks should consider investing in cryptocurrencies more seriously than they have in the past. According to the IMF staff team responsible for the note, including prominent economists such as Dong He, Ross Leckow, and Vikram Haksar, "rapid advances in digital technology are transforming the financial services landscape." These members of the IMF feel that such transformations generate new opportunities for consumers as well as service providers and regulators. The ultimate message of the report seems to be one of support for cryptocurrencies, as it outlines some of the ways that the fintech industry might be able to provide solutions for consumers related to trust, security, financial services, and privacy in this area.
One of the key findings of the IMF report is that "boundaries are blurring." This means that the borders between intermediaries, service providers, and markets, previously well-defined, have become blurry with the advent of new technology related to digital currencies and cross-border payments. Along with the blurring of these boundaries, the authors of the report suggest that "barriers to entry are changing." This does not, however, mean that barriers to entry are universally being lowered. Rather, they are being lowered in some situations but raised for others, particularly "if the emergence of large closed networks reduces opportunities for competition."
Absolutely key in the view of the authors of this report is that "trust remains essential." With less reliance on traditional intermediaries, consumers are turning more toward new networks and providers. The facilitation of this transfer on a large scale requires significant levels of trust in security, privacy, and efficiency. Along with this, and perhaps contributing to a new sense of trust, is the authors' conclusion that "technologies may improve cross-border payments" by serving better and more cost-efficient services, by lowering compliance costs, and by working to fight against terrorism financing.
In the view of the IMF authors, the financial services sector is poised to make the change toward cryptocurrency involvement. That being said, the report suggests that "policymaking will need to be nimble, experimental, and cooperative" in order to successfully navigate this crossing. Simultaneously, regulatory authorities will have a careful job to do: they must balance efficiency concerns and stability tradeoffs. In order to be willing to enter into this world, regulatory authorities will likely need reassurance that risks including cyberattacks, money-laundering, and terrorism support can be mitigated without harming the innovative progress of the digital currency world. To do this, the authors believe that regulators might need to increase their attention on activities and that governance will need to be strengthened. If all of these things take place, the IMF authors believe that banks could integrate cryptocurrencies successfully.
See the rest here:
IMF Urges Banks to Invest In Cryptocurrencies - Investopedia
Posted in Cryptocurrency
Comments Off on IMF Urges Banks to Invest In Cryptocurrencies – Investopedia
Investor Jitters and 4Chan Hoax Knock $4 Billion Off the Value of Ethereum Cryptocurrency – Gizmodo
Posted: at 6:51 am
Following a flash crash last Wednesday, the company that runs GDAX, an exchange for the ethereum digital currency, announced that it would pay back investors who lost money. If Mondays market performance for the cryptocurrency is any indication, that move didnt reassure investors.
Cryptocurrencies are risky as hell. A new competitor in the blockchain currency world, Ethereum,
The most reasonable explanation for why the Ethereum currency dropped from a high of $311.46 on Monday to a low of $238.65 is that a market correction is taking place for the out of control values of digital currencies. Analysts reasoned that investors who have seen their bets pay off decided today was a good time to take their money and run. Across the board, the most popular cryptocoins showed huge declines.
Ethereum, the second most popular coin offering around was particularly vulnerable today. It didnt experience the highest losses but it came close, shedding 19.79 percent of its value. The aforementioned flash crash and its recent notoriety mean that a lot of eyes were watching as its counter steadily ticked down. But some observers have placed part of the blame for Ethereums fall on the shameless tricksters on 4Chans /biz/ board.
On Sunday, an anonymous post appeared on 4Chan claiming:
Vitalik Buterin confirmed dead. Insiders unloading ETH. Fatal car crash. And now we have our answer. He was the glue. It will be difficult for ETH to recover and the entire crypto sphere is in big trouble.
Vitalik Buterin is the young inventor of the ethereum blockchain. Unlike the creator of bitcoin, hes not masking his identity. Hes also not dead. He also doesnt control ethereums decentralized network. But hes the face of his own creation and nervous investors may have seen the rumor as a good time to sell. Buterin quickly took to Twitter to issue proof of life through data from the most recent block in the chain.
According to Quartzs calculations, Sundays escapades knocked $4 billion off the digital currencys market value. At the time of posting, ethereum is worth $257.55 which is still way higher than the $8.37 it started at in January.
Thats nothing compared to bitcoin which is currently valued at $2376.29. The digital currency that started it all experienced an 8.81 percent decline today. Investor and crypto hedge fund manager Tim Enneking tells CoinDesk that this is the primary reason for todays market activity. When bitcoin sees a large move down, as weve seen in the past 48 hours, it still has a tendency to take the entire rest of the market with it, he says.
What goes up must come down. But Union Square Ventures partner Fred Wilson is feeling good about the long-term. My gut says we are headed for a selloff in the crypto sector, he wrote in a blog post on Monday. He says hes still convinced itll be a good bet over the next five or ten years. He also wrote, I am wrong a lot.
[CNBC, Quartz, CoinDesk]
See original here:
Investor Jitters and 4Chan Hoax Knock $4 Billion Off the Value of Ethereum Cryptocurrency - Gizmodo
Posted in Cryptocurrency
Comments Off on Investor Jitters and 4Chan Hoax Knock $4 Billion Off the Value of Ethereum Cryptocurrency – Gizmodo
What is the Biggest Security Threat to Ripple Cryptocurrency? – Investopedia
Posted: at 6:51 am
Ripple may be the latest craze in the cryptocurrency world. Although its price still lags far behind Ethereum and Bitcoin, it has nonetheless gained 3800% in recent months, catapulting it to the number 3 spot on the list of over 100 cryptocurrencies with regard to market capitalization. What's more important, perhaps, is the technology that Ripple offers aside from its currency. The Ripple blockchain protocol has gained recognition by more than 60 major financial institutions around the world, with the National Bank of Abu Dhabi one of the latest to incorporate it into its practices. Ripple has, in this way, broken a barrier that virtually no other cryptocurrency has, by finding a way to integrate itself within the broader financial world. To some, this spells a new way for the future of the digital currency industry. To others, though, Ripple has some significant security weaknesses. What could bring down this rising star?
A recent report by Technology Review discusses how Ripple has made use of a "small world" philosophy. According to this way of thinking, virtually anyone in the world can be connected to anyone else via approximately six steps. "Strangers" can thus be connected to one another via a few intermediary people, all of whom know each other in some capacity. For Ripple, this idea holds for transferring money: Ripple users establish connections with other users that they trust, and then funds are transferred along a chain to reach the ultimate recipient in a transaction.
Within Ripple, if a user has connections to two other users, the amounts of funds entrusted to each will likely vary, while the total transferred is kept constant in order to generate liquidity. Each user has an incentive to act as the intermediary, as he or she receives a small payment for the role. With this protocol, Ripple allows users to move funds quickly and for much less money in transaction fees than many other methods of money transfer. This has popularized the system with many banks that would have otherwise not been interested in a cryptocurrency.
The openness with which the Ripple network operates has, on the other hand, also allowed for vulnerabilities to develop. Researchers at Purdue University have found that, although the core of the network remains highly liquid, that the structure also allows for attacks on certain nodes within the network to cripple some users' access to funds. In fact, some 50,000 wallets may be immediately at risk if such an attack were to occur. However, the researchers suggest that the fact that they have been able to detect weaknesses in Ripple's system is actually a good thing, as the conventional world of banking often lacks transparency in this regard. Having identified those weaknesses, Ripple's developers may be able to work to correct them.
Continued here:
What is the Biggest Security Threat to Ripple Cryptocurrency? - Investopedia
Posted in Cryptocurrency
Comments Off on What is the Biggest Security Threat to Ripple Cryptocurrency? – Investopedia
Top 3 Recent Cryptocurrency ICOs Sorting Out Major Issues The … – The Merkle
Posted: at 6:51 am
If there is one thing to take away from most cryptocurrency ICOs as of late, it is how most of them run into some issue sooner or later. The Status ICO, for example, caused quite a few issues. The Monaco ICO needs to get tokens reissued, a process which is expected to be completed soon. It is evident there are a lot of issues behind the scenes which need to be worked out sooner or later. Below is a brief recap of recent ICOs currently resolving initial issues.
Although the SONM ICO has been quite successful in its own right, it is not without flaws by any means. A lot of people were surprised when the team announced they would accept multiple cryptocurrencies other than Ether. In hindsight, that was probably a bad decision, as it is causing major delays for ICO investors. More specifically, the team is still in the process of allocating tokens to investors who used currencies other than ETH to invest in the ICO. A very problematic development, and one that can linger for quite some time.
To make things even worse, a fair few investors are not too happy about the way things have been run. It is a bit unclear where this beef is coming from, but some investors have demanded a refund. Sorting out these issues takes up a lot of valuable time as well, which further delays the SNM token from getting listed on big exchanges. It appears SONM will sort things out shortly, but it is something to take into account.
The Status ICO has been subject to a lot of speculation and misinformation over the past week or so. It appears the smart contract used for the ICO was not full, but with the large pending queue of transactions, a lot of investors could not make a contribution. As a result, the Ethereum network got clogged up and started slowing down quite significantly The team feels this is no ones fault, as blockchains are highly experimental technology, and Ethereum is still in the testing phase. An interesting statement, although not a lot of people will agree.
Moreover, the Status team somewhat regrets using a dynamic ceiling for their cryptocurrency ICO. It is one of the main reasons why so many Ethereum transactions took place, as the maximum amount of Ether was a lot higher compared to what the team initially hoped to raise. It caused quite a bit of confusion and a lot of scaling issues for the network. It is evident this test was a good one, as it shows the Ethereum network is far less capable in this regard than most people think.
The Monaco ICO has proven to be quite successful, as many people feel this cryptocurrency debit card can make a big impact. Unfortunately, the ICO has been a bit of a hit-and-miss so far. Granted, the project raised a good amount of money, and people from all over the world invested in the crowdsale. That is where the good news ends, though, as none of the investors have received their official MCO tokens so far. The team is working together with TokenMarket to reissue the coins as quickly as possible.
The tokens have to be reissued because of an issue in the initial smart contract, which could cause multisig wallet incompatibility. All of the tokens have been issued on the Kovan testnet, and so far, things appear to be going quite well. However, it will take a few more days until all tokens are issued to investors, due to the ongoing Ethereum network issues. If all things go according to plan, tokens should be issued and tradeable by June 27th in the evening, at the latest. It is good to see TokenMarket work on this matter alongside the Monaco team.
If you liked this article, follow us on Twitter @themerklenews and make sure to subscribe to our newsletter to receive the latest bitcoin, cryptocurrency, and technology news.
Originally posted here:
Top 3 Recent Cryptocurrency ICOs Sorting Out Major Issues The ... - The Merkle
Posted in Cryptocurrency
Comments Off on Top 3 Recent Cryptocurrency ICOs Sorting Out Major Issues The … – The Merkle
Bitcoin, ether lead cryptocurrency slide – TechCentral
Posted: at 6:51 am
Bitcoin declined as much as 17% on Monday, while smaller competitor ether continued to slide after experiencing a flash crash last week, raising concern about mainstream acceptance of the digital currencies.
Bitcoin slumped to as low as US$2 255.44 in intraday trading, the least since 15 June. Ether, the virtual currency based on the ethereum blockchain, plunged 26% to $221.45, according to data compiled by Coindesk.com. And ripple, the third largest digital currency based on market cap, has dropped about 13% to around $0.26, according to prices compiled by CoinMarketCap.com.
Ether slumped on 21 June after congestion on its network slowed transactions, causing some cryptocurrency exchanges such as Bitfinex and ShapeShift to halt transactions.
Coinbases GDAX exchange experience a flash crash, as price slippage sent ether to trade around $0.10, said GDAX vice president Adam White, who on Monday decided to reverse an earlier decision not to refund flash-crash victims. He said the crash on GDAX was instigated by a multimillion-dollar market sell order.
The two biggest digital currencies have still surged in value this year. Ether started the year around $8, meaning even with its current drop, the price has doubled many times over. Bitcoin has advanced about 150% year to date.
When people fixate on price movements over a single day, my recommendation is zoom out of the price chart and look at the broader trend, said Peter Van Valkenburgh, director of research at Coin Centre, a Washington-based nonprofit research firm focusing on cryptocurrencies.
Blockchain could either catch on as the rails for global finance, or not, so valuations for a digital currency like bitcoin can either go to zero or be worth much more than it is today, so these assets are bound to be very volatile as peoples calculations of what they are worth can be all over the map.
Coinbase was down earlier on Monday, according to online forums on ether, which could explain some of the losses, as this comes after other exchanges temporarily suspended trading last week due to a bottleneck on ether orders.
The steeper decline in ether than bitcoin means ethers market cap at $25bn is now just about 60% of bitcoins, down from about 80%, when ether climbed over $400 two weeks ago. The rapid growth of the ethereum network had prompted speculation that ether would overtake bitcoin to become the biggest cryptocurrency as soon as this year, a phenomenon known as the flippening.
Chip makers that had benefited from cryptocoin miners last week are now giving up some of those gains. Nvidia dropped for the third consecutive day, slumping 1.1% to $152.15/share. Advanced Micro Devices dropped 0.6% to $14.08. Reported by Alexandria Arnold and Camila Russo, (c) 2017 Bloomberg LP
More:
Bitcoin, ether lead cryptocurrency slide - TechCentral
Posted in Cryptocurrency
Comments Off on Bitcoin, ether lead cryptocurrency slide – TechCentral
Cryptocurrency: How We Hook the Masses – CoinDesk
Posted: at 6:51 am
Rich Svinkin is the CEO of Jaywalk.me, a startup that motivates increased physical activity with brick-and-mortar retail rewards.
In this opinion piece,Svinkin argues that using cryptocurrencies for rewards schemes can demonstrate the value of the technology and ultimately help bring mass adoption.
Before the hype and before the price explosions of the past year, I sat down and looked at cryptocurrencies from a UXperspective.
That post, published on CoinDesk,offered a simple central premise: the entire bitcoin project was envisioned, designed, built and released as a peer-to-peer value exchange system. It wasn't supposed to be a standalone asset class or a messaging system for banks.
A year later, we're in the midst of a hype-ridden initial coin offering (ICO) explosion. ICOs are another use case in the UX quiver, one we can add to the progress of the last few years. The ICOs (I prefer to call them token sales) are a great engine of growth but they do not achieve our ultimate goal: adoption of cryptocurrency by the masses.
Prior to Jobs and Wozniak, computers were the domain of engineers, hobbyists, large corporations and government agencies. The dominant framework for users to interact with these machines, the command line, ensured low user adoption.
As Neal Stephenson noted, however, the wizards who held sway over the simple cursor and text interfaces later built the tools to drive mass adoption. From the command line, we moved into something relatable and simple, and, in the process, we hid all of the piping behind wall after wall of abstraction.
I don't want to understate how big of a leap this was for my generation. You mean we can make the screen do what we want like an arcade game? We can "save" what we're doing and come back to it later? We can put stuff on a disk and put it on another computer? Wow!
After we were hooked, we started learning heuristics for the things we'd need to master to get more out of the experience. We started implicitly understanding what a KB meant. We grew to "kinda know" how much would fit on a floppy disk.
Some of us started learning how to make simple animations and games. The computer was at first a toy then a tool.
I argue that, in the crypto space, we're at the point in our evolution where the command-line is giving way to new and more generalized heuristics with similarly explosive opportunities. Right now, the equivalent of the command line are things like wallet addresses, private keys, cold storage, and other obfuscating elements.
I wrote a year ago that I think we need a Steve Jobs in this space. No one has yet stepped up to the plate.
Even if regular people were to learn all the terms of art, master using the exchanges, grow comfortable with identity verification and currency exchange rates, and accept the long wait times in transferring fiat in/out, we'd still have a problem that would keep the bulk of the planet off the chain in a meaningful way: risk.
Modern operating systems mitigate risk immensely. Every program we use has some sort of backup system and now you rarely lose work. With cryptocurrencies, the existential threat of losing everything is still there.
The best way to deal with risk, at least at the start, is to try to eliminate it. We must not treat crypto like a competitive currency at least not now. Instead we must treat it like a reward, something new.
We must allow people to buy it, but also allow folks to earn it, with their time, effort, attention, with non-monetary capital. Don't force people to have to buy it with fiat.
Instead, let them earn it.
There are folks that are on a rewards-oriented path: Steemit, Brave, Bitwalking, Metal and others.
This is going to be a growing trend in the months and years to come. All of them want to reward you for something Steemit for creating and engaging with digital content, Bitwalking just for walking. Brave is taking things to the next level: you get rewards just for using a secure browser and for engagement and attention.
Metal will reward you for converting, sending and spending.
All are trying to get to the same goal: they want the cryptocurrency they've issued to become valuable in the real world, to become the lifeblood of a new economy centered around a particular set of use cases.
The success of these products is dependent on ultimately hooking the masses via a rewards-based introduction points, miles, cash back these are notions we all get, just like I did 30 years ago with writing, drawing and reading on the Mac.
But the final step requires users to make that leap from rewards to currency for this revolution to get to the next level. And for that goal, I a true believer am very hopeful with this recent wave.
That said,I still have one hesitation. All of these solutions make progress on the various complexities and issues surrounding adoption.
But, the one thing they all do not do, is obfuscate the currency exchange problem inherent in forging ahead with something new right away. It can show the value of the new currency in terms of fiat, but even currency earned through effort will be at risk of losing credibility and lasting power.
There will always be fear that the $398 I have in crypto will one day be $0, or in anhour will be worth $118.
Sure, we could be at the start of a fiat currency collapse and not even know it, as the market cap of crypto currency rockets up. This may even be good for the whole system. But, even if the crypto world supersedes the money we know, it will be the option with the most perceived stability that ends up winning. Not the ones with the most speculative upside or interesting "applications."
Well know we've "won" when a cryptocurrency becomes woven into the daily lives of the majority of people on earth. That people recognize finally that the fiat they know is also volatile and purchasing power is dynamic and ever changing, and cryptocurrency has many other benefits the analog doesnt have. Or simply that a cryptocurrency finally becomes more stable so people run to it to escape losing all their value in government-backed money as a crisis looms or is underway.
Until then, it's hard to say what weve accomplished truly, but the goal is ultimately that we move belief in fiat money to belief in cryptocurrency.
To me, the best way to start that transition is to get people used to and interested in this new phenomenon by utilizing familiar bridges like air miles and minimizing fear and risk to allow for everyday use to come to bear and even bring some fun to the strange world of cryptocurrencies.
Disclosure: CoinDesk is a subsidiary of Digital Currency Group, which has an ownership stake in Brave.
Mac computer image via Shutterstock
The leader in blockchain news, CoinDesk strives to offer an open platform for dialogue and discussion on all things blockchain by encouraging contributed articles. For more details on how you can submit an opinion or analysis article, view our Editorial Collaboration Guide or email [emailprotected].
Posted in Cryptocurrency
Comments Off on Cryptocurrency: How We Hook the Masses – CoinDesk
Zionsville Community High School student has entrepreneurial spirit – Current in Zionsville
Posted: at 6:49 am
By Mark Ambrogi
Grace Curry has embraced the entrepreneurial spirit.
Grace Curry displays the phone cases she sells through Violet Satin (Submitted photo).
Ive always been interested in making my own money as a child, selling jewelry, lemonade, inventing things, she said. I really enjoy being able to put the business together by myself, and I love marketing and advertising.
Curry, who just finished her sophomore year at Zionsville Community High School, is the founder of Violet Satin, an online company that sells iPhone cases for women and other phone accessories. The company ships to anywhere in the U.S., and customers have come from all across the nation.
Curry, who started the business in February 2016, said she designs some of the phone cases that are on her website, and the production comes from manufacturers online.
I have a website that is connected to my online website that creates custom-made products, Curry said.
It took approximately four to five months for her business to really become profitable, Curry said. Instagram is the primary source of promotion to her website. Violet Satin has more than 13,000 Instagram followers.
In addition to her business, Curry has a part-time job at Hot Box Pizza. A member of the Equality Club, among other clubs, Curry plans to join the cross country team in 2017. She competed in cross country in eighth grade.
Her plan is to major in biology and minor in business in college.
I have been into genetic engineering ever since I took biology in high school, and then genetics this year, she said. I am interested in using genetic engineering to further technology with food and medicine.
For more, visit violetsatin.com.
See the original post:
Zionsville Community High School student has entrepreneurial spirit - Current in Zionsville
Posted in Genetic Engineering
Comments Off on Zionsville Community High School student has entrepreneurial spirit – Current in Zionsville
Gene mutation linked to retinitis pigmentosa in Southwestern US Hispanic families – Medical Xpress
Posted: at 6:48 am
June 27, 2017
Thirty-six percent of Hispanic families in the U.S. with a common form of retinitis pigmentosa got the disease because they carry a mutation of the arrestin-1 gene, according to a new study from researchers at The University of Texas Health Science Center at Houston (UTHealth) School of Public Health.
Retinitis pigmentosa is a group of rare, genetic eye disorders in which the retina of the eye slowly degenerates. The disease causes night blindness and progressive loss of peripheral vision, sometimes leading to complete blindness. According to Stephen P. Daiger, Ph.D., senior author of the study, an estimated 300,000 people in the U.S. suffer from the disease, which gets passed down through families.
In the study published recently in Investigative Ophthalmology & Visual Science, UTHealth researchers found that in a U.S. cohort of 300 families with retinitis pigmentosa, 3 percent exhibited a mutation of the arrestin-1 gene. However, more than 36 percent of Hispanic families from the cohort exhibited the arestin-1 mutation and they all came from areas in the Southwestern U.S., such as Texas, Arizona and Southern California.
"When I started studying retinitis pigmentosa in 1985, we set out to find the 'one' gene that causes the disease. Thirty-three years later, we've found that more than 70 genes are linked to retinitis pigmentosa," said Daiger, a professor in the Human Genetics Center and holder of the Thomas Stull Matney, Ph.D. Professorship in Environmental and Genetic Sciences at UTHealth School of Public Health.
Some of the genes that cause retinitis pigmentosa are recessive, which means two mutations are required, and some are dominant, which means you only need one mutation. Arrestin-1 piqued Daiger's interest because that particular mutation is dominant while all previously found mutations in the gene are recessive. This unexpected finding shows that even a single mutation in the gene is sufficient to cause the disease.
Daiger and his team have identified the genetic cause of retinitis pigmentosa for 75 percent of families in their cohort. Possible treatments for some forms of retinitis pigmentosa are being tested but are still limited. However, the speed at which companies are developing gene therapies and small molecule therapies gives reason to hope, he said. Daiger and his collaborators have begun to connect some of the patients in the retinitis pigmentosa cohort to clinical trials that treat specific genes.
"I want our cohort families to know that even if there is not an immediate cure for their specific gene mutation, at this rate it won't be long until a therapy becomes available," said Daiger, who also holds the Mary Farish Johnston Distinguished Chair in Ophthalmology at McGovern Medical School at UTHealth.
Support for the study, titled "A novel dominant mutation in SAG, the arrestin-1 gene, is a common cause of retinitis pigmentosa in Hispanic families in the Southwestern United States," was provided by the William Stamps Farish Fund and the Hermann Eye Fund.
Explore further: Scientists discover gene tied to profound vision loss
More information: Lori S. Sullivan et al. A Novel Dominant Mutation in SAG, the Arrestin-1 Gene, Is a Common Cause of Retinitis Pigmentosa in Hispanic Families in the Southwestern United States, Investigative Opthalmology & Visual Science (2017). DOI: 10.1167/iovs.16-21341
An exhaustive hereditary analysis of a large Louisiana family with vision issues has uncovered a new gene tied to an incurable eye disorder called retinitis pigmentosa, according to an examination led by scientists at The ...
Researchers have started a new gene therapy clinical trial to treat X-linked retinitis pigmentosa (XLRP), the most common cause of blindness in young people.
An international team of researchers has discovered that mutations in the human gene CWC27 result in a spectrum of clinical conditions that include retinal degeneration and problems with craniofacial and skeletal development. ...
Progressive development of night blindness and tunnel vision, sometimes from the early age of 2, are trademarks of retinitis pigmentosa. Being the most common inherited disorder of the retina, retinitis pigmentosa affects ...
Columbia University Medical Center (CUMC) and University of Iowa scientists have used a new gene-editing technology called CRISPR, to repair a genetic mutation responsible for retinitis pigmentosa (RP), an inherited condition ...
Researchers at UCL Institute of Ophthalmology and Moorfields Eye Hospital with funding from Fight for Sight, in collaboration with a team from Baylor College of Medicine in the USA, have discovered a new retinitis pigmentosa ...
Using a new skin cell model, researchers have overcome a barrier that previously prevented the study of living tissue from people at risk for early heart disease and stroke. This research could lead to a new understanding ...
A research team has successfully used magnets implanted behind a person's eyes to treat nystagmus, a condition characterised by involuntary eye movements.
The first results from a functional genetic catalogue of the laboratory mouse has been shared with the biomedical research community, revealing new insights into a range of rare diseases and the possibility of accelerating ...
Whole genome sequencing involves the analysis of all three billion pairs of letters in an individual's DNA and has been hailed as a technology that will usher in a new era of predicting and preventing disease. However, the ...
Researchers have found that genes for coronary heart disease (CAD) also influence reproduction, so in order to reproduce successfully, the genes for heart disease will also be inherited.
When Ricky Ramon was 7, he went for a routine checkup. The pediatrician, who lingered over his heartbeat, sent him for a chest X-ray, which revealed a benign tumor in the top-left chamber of his heart. For Ramon, it was the ...
Please sign in to add a comment. Registration is free, and takes less than a minute. Read more
Visit link:
Gene mutation linked to retinitis pigmentosa in Southwestern US Hispanic families - Medical Xpress
Posted in Human Genetics
Comments Off on Gene mutation linked to retinitis pigmentosa in Southwestern US Hispanic families – Medical Xpress
Genomic sequencing may benefit parents of cancer patients – Baylor College of Medicine News (press release)
Posted: at 6:48 am
In a new paper recently published in the Journal of Clinical Oncology: Precision Oncology, researchers at Baylor College of Medicine and Texas Childrens Hospital report that genomic sequencing information may be more valuable for families of pediatric cancer patients than has previously been recognized.
The paper reports results from the Baylor Advancing Sequencing in Childhood Cancer Care (BASIC3) study led by Baylors Dr. Sharon Plon, professor of pediatrics-oncology and molecular and human genetics; Dr. Will Parsons, associate professor of pediatrics-oncology and molecular and human genetics; and Dr. Amy McGuire, director of the Center for Medical Ethics and Health Policy. The BASIC3 study evaluates the impact of incorporating a type of genomic sequencing called whole exome sequencing into the clinical care of children newly diagnosed with cancer being treated at Texas Childrens Cancer Center. This technology can reveal information about the genetics of the childs tumor as well as identify genes that the patient or parents may have that are associated with cancer, other diseases and conditions that would require immediate clinical action. Most parents also opted to find out if they or their child carry a gene for a disease that they could pass on to future generations. Through this study, investigators sought to understand what parents of newly diagnosed pediatric cancer patients think about receiving this type of information.
The BASIC3 research team interviewed more than 60 parents before and after they received their childs exome sequencing results. Parents described a wide range of ways in which they found the information valuable for their child, themselves and other family members. As expected, parents hoped that the information would improve their childs care through cancer treatment tailored to their childs specific cancer or through appropriate monitoring in the future. However, they also perceived benefit of whole exome sequencing even when it would not change the childs clinical care.
Concerns about how children and parents will react to genomic sequencing information as well as respect for the future rights of children to decide whether they want that information have led to a general consensus against disclosing sequencing information that does not have clear clinical utility, said McGuire, one of the principal investigators of the BASIC3 study. However, our study showed that parents of children with a serious illness found this information valuable for a wide variety of reasons, which raises questions about whether this consensus is appropriate for this population.
Parents in the BASIC3 study wanted to know where their childs cancer had come from and hoped that genomic sequencing would help them understand why this had happened to their family. They described relief from both guilt and worry upon finding that their childs disease was not caused by a known cancer-related gene. Parents who discovered their child had a genetic risk of cancer expressed that having that knowledge could help the child make their own reproductive decisions. In addition, some parents noted that the exome sequencing results prompted them to have the childs siblings and other family members receive genetic testing to assess their risk. If no genetic risk of cancer or other diseases was discovered, parents felt reassured of the health of their other children, including any potential children in the future.
On the whole, parents were remarkably positive about genomic sequencing, even if the results did not change their childs medical treatment, said Dr. Janet Malek, first author of the paper and associate professor of medicine and medical ethics at the Center for Medical Ethics and Health Policy. They found the information valuable for themselves and other family members in a broad range of ways. These results suggest that we need to think carefully about how we understand the risks and benefits of using this technology, when we should recommend its use and how we talk about it with patients and families.
The results from this interview study improve the understanding of parents perspectives of whole exome sequencing. Researchers and clinicians can use parents broad range of utility to re-evaluate how risks and benefits should be described and to inform decisions about using whole exome sequencing in clinical care. The Baylor team is planning to continue researching this topic with a new and larger longitudinal survey based-study across multiple sites in Texas that will compare the various benefits and concerns of receiving exome sequencing results. Currently, Malek and colleagues are analyzing what the roles of guilt, regret and parental responsibility have in how parents in the BASIC3 study perceive the value of their childs whole exome sequencing results.
Other contributors to this work include Dr. Melody Slashinski, Jill Robinson, Amanda Gutierrez, and Dr. Laurence McCullough. Drs. Plon, McGuire and Parsons are also members of the NCI-designated Dan L Duncan Comprehensive Cancer Center at Baylor. The BASIC3 study is a Clinical Sequencing Exploratory Research (CSER) program project supported by Grant No. 1U01HG006485 from the National Human Genome Research Institute, National Cancer Institute.
Original post:
Genomic sequencing may benefit parents of cancer patients - Baylor College of Medicine News (press release)
Posted in Human Genetics
Comments Off on Genomic sequencing may benefit parents of cancer patients – Baylor College of Medicine News (press release)
Mice provide insight into genetics of autism spectrum disorders – Medical Xpress
Posted: at 6:48 am
June 27, 2017 by David Slipher In this mouse cortex, a mutation in the CHD8 gene caused increased brain size, or megalencephaly, a condition also present in people with autism spectrum disorder. The colored sections correspond to different layers of the developing cortex. Credit: Alex Nord/UC Davis
While the definitive causes remain unclear, several genetic and environmental factors increase the likelihood of autism spectrum disorder, or ASD, a group of conditions covering a "spectrum" of symptoms, skills and levels of disability.
Taking advantage of advances in genetic technologies, researchers led by Alex Nord, assistant professor of neurobiology, physiology and behavior with the Center for Neuroscience at the University of California, Davis, are gaining a better understanding of the role played by a specific gene involved in autism. The collaborative work appears June 26 in the journal Nature Neuroscience.
"For years, the targets of drug discovery and treatment have been based on an unknown black box of what's happening in the brain," said Nord. "Now, using genetic approaches to study the impact of specific mutations found in cases, we're trying to build a cohesive model that links genetic control of brain development with behavior and brain function."
The Nord laboratory studies how the genome encodes brain development and function, with a particular interest in understanding the genetic basis of neurological disorders.
Mouse brain models
There is no known specific genetic cause for most cases of autism, but many different genes have been linked to the disorder. In rare, specific cases of people with ASD, one copy of a gene called CHD8 is mutated and loses function. The CHD8 gene encodes a protein responsible for packaging DNA in cells throughout the body. Packaging of DNA controls how genes are turned on and off in cells during development.
Because mice and humans share on average 85 percent of similarly coded genes, mice can be used as a model to study how genetic mutations impact brain development. Changes in mouse DNA mimic changes in human DNA and vice-versa. In addition, mice exhibit behaviors that can be used as models for exploring human behavior.
Nord's laboratory at UC Davis and his collaborators have been working to characterize changes in brain development and behavior of mice carrying a mutated copy of CHD8.
"Behavioral tests with mice give us information about sociability, anxiety and cognition. From there, we can examine changes at the anatomical and cellular level to find links across dimensions," said Nord. "This is critical to understanding the biology of disorders like autism."
By inducing mutation of the CHD8 gene in mice and studying their brain development, Nord and his team have established that the mice experience cognitive impairment and have increased brain volume. Both conditions are also present in individuals with a mutated CHD8 gene.
New implications for early and lifelong brain development
Analysis of data from mouse brains reveals that CHD8 gene expression peaks during the early stages of brain development. Mutations in CHD8 lead to excessive production of dividing cells in the brain, as well as megalencephaly, an enlarged brain condition common in individuals with ASD. These findings suggest the developmental causes of increased brain size.
More surprisingly, Nord also discovered that the pathological changes in gene expression in the brains of mice with a mutated CHD8 continued through the lifetime of the mice. Genes involved in critical biological processes like synapse function were impacted by the CHD8 mutation. This suggests that CHD8 plays a role in brain function throughout life and may affect more than early brain development in autistic individuals.
While Nord's research centers on severe ASD conditions, the lessons learned may eventually help explain many cases along the autism spectrum.
Collaborating to improve understanding
Nord's work bridges disciplines and has incorporated diverse collaborators. The genetic mouse model was developed at Lawrence Berkeley National Laboratory using CRISPR editing technology, and co-authors Jacqueline Crawley and Jill Silverman of the UC Davis MIND Institute evaluated mouse behavior to characterize social interactions and cognitive impairments.
Nord also partnered with co-author Konstantinos Zarbalis of the Institute for Pediatric Regenerative Medicine at UC Davis to examine changes in cell proliferation in the brains of mice with the CHD8 mutation, and with Jason Lerch from the Mouse Imaging Centre at the Hospital for Sick Children in Toronto, Canada, to conduct magnetic resonance imaging on mouse brains.
"It's the act of collaboration that I find really satisfying," Nord said. "The science gets a lot more interesting and powerful when we combine different approaches. Together we were able to show that mutation to CHD8 causes changes to brain development, which in turn alters brain anatomy, function and behavior."
In the future, Nord hopes to identify how CHD8 packages DNA in neural cells and to determine the specific impacts to early brain development and synaptic function. Nord hopes that deep exploration of CHD8 mutations will ultimately yield greater knowledge of the general factors contributing to ASD and intellectual disability.
Explore further: Study shows connection between key autism risk genes in the human brain
More information: Andrea L Gompers et al. Germline Chd8 haploinsufficiency alters brain development in mouse, Nature Neuroscience (2017). DOI: 10.1038/nn.4592
Journal reference: Nature Neuroscience
Provided by: UC Davis
A new study reveals an important connection between dozens of genes that may contribute to autism, a major step toward understanding how brain development goes awry in some individuals with the disorder.
In a collaboration involving 13 institutions around the world, researchers have broken new ground in understanding what causes autism. The results are being published in Cell magazine July 3, 2014: "Disruptive CHD8 Mutations ...
Autistic-like behaviors and decreased cognitive ability may be associated with disruption of the function of the Adenomatous Polyposis Coli (APC) gene. When Tufts researchers deleted the gene from select neurons in the developing ...
Scientists studying the role of a protein complex in the normal development of the mouse brain unexpectedly created a mouse model that replicates clinical symptoms of patients with complex neurological disorders such as hyperactivity, ...
In the nucleus of eukaryotic cells, DNA is packaged with histone proteins into complexes known as chromatin, which are further compacted into chromosomes during cell division. Abnormalities in the structure of chromosomes ...
A new Northwestern Medicine study found evidence suggesting how neural dysfunction in a certain region of the brain can lead to obsessive and repetitive behaviors much like obsessive-compulsive disorder (OCD).
While the definitive causes remain unclear, several genetic and environmental factors increase the likelihood of autism spectrum disorder, or ASD, a group of conditions covering a "spectrum" of symptoms, skills and levels ...
Many cognitive processes, such as decision-making, take place within seconds or minutes. Neuroscientists have longed to capture neuron activity during such tasks, but that dream has remained elusiveuntil now.
Many genes linked to late-onset Alzheimer's disease (AD) are expressed in myeloid cells and regulated by a single protein, according to research conducted at the Icahn School of Medicine at Mount Sinai and published June ...
Neuroscientists from the University of Chicago have developed a computer model that can simulate the response of nerves in the hand to any pattern of touch stimulation on the skin. The tool reconstructs the response of more ...
Viruses have evolved to be highly effective vehicles for delivering genes into cells. Seeking to take advantage of these traits, scientists can reprogram viruses to function as vectors, capable of carrying their genetic cargo ...
Since scientists began studying the brain, they have asked whether the biology they observed can really be tied to external behaviors. Researchers are building a substantial understanding of the biophysical, molecular, and ...
Please sign in to add a comment. Registration is free, and takes less than a minute. Read more
See the article here:
Mice provide insight into genetics of autism spectrum disorders - Medical Xpress
Posted in Human Genetics
Comments Off on Mice provide insight into genetics of autism spectrum disorders – Medical Xpress







