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Daily Archives: June 29, 2017
CF Mller appointed on Robin Hood Gardens replacement scheme – Dezeen
Posted: June 29, 2017 at 11:21 am
Scandinavian firmCF Mllerhas been appointed alongsideHaworth Tompkinsand Metropolitan Workshop on the housing scheme that will replaceRobin Hood Gardens,the brutalist estate in east London designed byAlison and Peter Smithson.
CF Mller's housing will take the place of the eastern block of the iconic estate,while residences by Haworth TompkinsandMetropolitan Workshop who were appointed to the scheme in 2016 will sit on the site of the west wing.
The plansform part of the300 million regeneration of the Robin Hood Gardens estate in Popular, which is being overseenbySwan Housing Association.
The estate, which was completed in 1974, is currently awaiting its demolition, despite a high-profile campaign to save it as aprime example of the brutalist movement.
Dezeen recently used a drone to film the estate, which is partially deserted and boarded up in preparation for its demolition in the coming weeks.
CF Mller's design will provide 330 homes half of which are to be earmarked as affordable for the regeneration schemeknown as theBlackwall Reach Regeneration Project.
Early visuals show the range of one- to five-bedroom flats contained within a brick-clad block on the edge of the garden that currently separates the two wings of the brutalist estate. This outdoor space with its distinctive mound is the only element of Robin Hood Gardens that will be retained. It is to be re-landscaped and renamed theMillennium Green.
"Our approach to this challenging project is to develop an architectural and place-making response with the focus on designing the best possible new homes within a challenging location," saidCF Mller associate partnerRolf Nielsen.
CF Mller's housing will form phase threeof theBlackwall Reach Regeneration Project, which will see 1,500 apartments, commercial spaces and a mosque packed onto thesite beside Blackwall Tunnel thatcurrently offers 252 homes.
Phase one is currently underway, with 98 homes already on site, alongside the mosque, a community centre and an extension of a neighbouring school. Yet to come in this phase which is set for completion in early 2019 are 242 further homes, as well as shops and cafes.
Phase two is expected to begin imminently, and will see the delivery of four buildings byMetropolitan Workshop and Haworth Tompkins, which are to provide 268 homes.
"We were very impressed by their 'inside-out approach' to design. CF Mller really focused on the people who will live in these new homes and the relationship of the homes to the public realm," said Swan's regeneration and development directorGeoff Pearce.
"They were passionate about ensuring we deliver human-scale street scenes and links into the landscape to offset the impact of the busy external environment," he added.
Robin Hood Gardens is consideredexemplary of new brutalism, an architectural stylegaining its name from the French bton-brut, or raw concrete, used to form the structures.
Architects including Richard Rogers, the late Zaha Hadid, Toyo Ito and Robert Venturi, as well as the Smithson's son, all petitioned to save the estate. But the campaign failed and politicians have been calling for its demolition since.
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These Stock’s are Flying High, But Don’t Go Contrarian Yet: CF Industries Holdings, Inc. (CF), Zillow Group, Inc. (Z) – StockNewsJournal
Posted: at 11:21 am
These Stock's are Flying High, But Don't Go Contrarian Yet: CF Industries Holdings, Inc. (CF), Zillow Group, Inc. (Z) StockNewsJournal CF Industries Holdings, Inc. (NYSE:CF) market capitalization at present is $6.33B at the rate of $27.17 a share. The firm's price-to-sales ratio was noted 1.69 in contrast with an overall industry average of 3.79. Most of the active traders and ... |
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3 stories that prove political correctness has gone too far Jim Gearhart podcast – New Jersey 101.5 FM Radio
Posted: at 11:20 am
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If youre a regular listener of Jim Gearharts podcast, or you enjoyed his 25-year stint leading New Jersey 101.5s morning show, were not telling you anything new by saying he doesnt enjoy political correctness.
But some stories, Jim says, are more absurd than others.
I just throw these out as a couple of examples of how weve gone stark raving damn mad, Jim says in this weeks installment of the Jim Gearhart Show podcast, available here, on iTunes and Google Play.
How about the story of Professor Bret Weinstein at Evergreen State College in Olympia, Wash., who had the gall to oppose the schools annual Day of Absence, or rather, this years reversal of it. Traditionally, students and faculty of color would skip out on the campus for a day and meet elsewhere, to show what life would be like when theyre not around. This year, white students and faculty were invited to step away, after minorities expressed concerns they didnt feel safe following the 2016 election.
He was a very liberal person, but he said that was going too far, Jim says. But to Jim, what was really to far was the backlash Weinstein received including threats and harassment.
This is how serious this has gotten, Jim says.
But thats not the only story hes got lined up. Check out the podcast to hear the rest. Email Jim at Jim@NJ1015.com.
The Jim Gearhart Podcast is available every week on New Jersey 101.5 and in the New Jersey 101.5 app. You can alsosubscribe with your favorite podcasting app for iPhones, Android devices or your computer:
Get The Jim Gearhart Show on Google Play
Get Jim on iTunes
Love podcasts? Also check out Forever 39, Annette and Megans new podcast about turning 40 and loving life along the way. This week, they explore the stresses so many of us face and how to escape them.
Also: The New Jersey Guys, Chris and Dan, are joined this week by NJ Devils legend Ken Daneyko. And in Speaking Millennial, Bill Spadea, Jay Black and Jessica Nutt proclaim (profanely) Eff the future!
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Forget political correctness; time to profile young black men | Myrtle … – Myrtle Beach Sun News
Posted: at 11:20 am
Forget political correctness; time to profile young black men | Myrtle ... Myrtle Beach Sun News If we want to put an end to the shootings in Myrtle Beach and elsewhere in the former great country of ours, we need to do one simple thing: start profiling. |
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Cloning Thousands of Genes for Massive Protein Libraries – Lab Manager Magazine
Posted: at 11:19 am
New DNA-based LASSO molecule probe can bind target genome regions for functional cloning and analysis.Image credit: Jennifer E. Fairman/Johns Hopkins UniversityDiscovering the function of a gene requires cloning a DNA sequence and expressing it. Until now, this was performed on a one-gene-at-a-time basis, causing a bottleneck. Scientists atRutgers University-New Brunswickin collaboration with Johns Hopkins University and Harvard Medical School have invented a technology to clone thousands of genes simultaneously and create massive libraries of proteins from DNA samples, potentially ushering in a new era of functional genomics.
We think that the rapid, affordable, and high-throughput cloning of proteins and other genetic elements will greatly accelerate biological research to discover functions of molecules encoded by genomes and match the pace at which new genome sequencing data is coming out, saidBiju Parekkadan, an associate professor in theDepartment of Biomedical Engineeringat Rutgers University-New Brunswick.
In a study published online June 26in the journalNature Biomedical Engineering, the researchers showed that their technologyLASSO (long-adapter single-strand oligonucleotide) probescan capture and clone thousands of long DNA fragments at once.
As a proof-of-concept, the researchers cloned more than 3,000 DNA fragments fromE. coli bacteria, commonly used as a model organism with a catalogued genome sequence available.
We captured about 95 percent of the gene targets we set out to capture, many of which were very large in DNA length, which has been challenging in the past, Parekkadan said. I think there will certainly be more improvements over time.
They can now take a genome sequence (or many of them) and make a protein library for screening with unprecedented speed, cost-effectiveness and precision, allowing rapid discovery of potentially beneficial biomolecules from a genome.
In conducting their research, they coincidentally solved a longstanding problem in the genome sequencing field. When it comes togenetic sequencingof individual genomes, todays gold standard is to sequence small pieces of DNA one by one and overlay them to map out the full genome code. But short reads can be hard to interpret during the overlaying process and there hasnt been a way to sequence long fragments of DNA in a targeted and more efficient way. LASSO probes can do just this, capturing DNA targets of more than 1,000 base pairs in length where the current format captures about 100 base pairs.
The team also reported the capture and cloning of the first protein library, or suite of proteins, from a human microbiome sample. Shedding light on thehuman microbiomeat a molecular level is a first step toward improving precision medicine efforts that affect the microbial communities that colonize our gut, skin, and lungs, Parekkadan added.Precision medicine requires a deep and functional understanding, at a molecular level, of the drivers of healthy and disease-forming microbiota.
Today, the pharmaceutical industry screens synthetic chemical libraries of thousands of molecules to find one that may have a medicinal effect, said Parekkadan, who joined RutgersSchool of Engineeringin January.
Our vision is to apply the same approach but rapidly screen non-synthetic, biological or natural molecules cloned from human or other genomes, including those of plants, animals and microbes, he said. This could transform pharmaceutical drug discovery into biopharmaceutical drug discovery with much more effort.
The next phase, which is underway, is to improve the cloning process, build libraries and discover therapeutic proteins found in our genomes, Parekkadan said.
Other authors include Lorenzo Tosi, Viswanadham Sridhara, Yunlong Yang, Dongli Guan, and Polina Shpilker of Harvard Medical School; Nicola Segata of the University of Trento in Trento, Italy; and H. Benjamin Larman of Johns Hopkins University.
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A billion-year arms race against viruses shaped our evolution – Nature – Nature.com
Posted: at 11:19 am
Kateryna Kon/Science Photo Library
Viruses have evolved to invade the cells of plants, animals and other organisms.
Viruses and their hosts have been at war for more than a billion years. This battle has driven a dramatic diversification of viruses and of host immune responses. Although the earliest antiviral systems have long since vanished, researchers may now have recovered remnants of one of them embedded, like a fossil, in human cells.
A protein called Drosha, which helps to control gene regulation in vertebrates, also tackles viruses, researchers report today in Nature1. They suggest that Drosha and the family of enzymes, called RNAse III, it belongs to were the original virus fighters in a single-celled ancestor of animals and plants. You can see the footprint of RNAse III in the defence systems through all kingdoms of life, says Benjamin tenOever, a virologist at Icahn School of Medicine at Mount Sinai in New York and lead author of the paper.
Plants and invertebrates deploy RNAse III proteins in an immune response called RNA interference, or RNAi. When a virus infects a host, the proteins slice the invaders RNA into chunks that prevent it from spreading. But vertebrates take a different approach, warding off viruses with powerful interferon proteins while Drosha and a related protein regulate genes in the nucleus.
But in 2010, tenOever witnessed an odd phenomenon: Drosha appeared to leave the nucleus of human cells whenever a virus invaded2. That was weird and made us curious, tenOever says. His team later confirmed the finding, and saw that Drosha demonstrates the same behaviour in cells from flies, fish and plants.
To test the hypothesis that Drosha leaves the nucleus to combat viruses in vertebrates, the researchers infected cells that had been genetically engineered to lack Drosha with a virus. They found that the viruses replicated faster in these cells. The team then inserted Drosha from bacteria into fish, human and plant cells. The protein seemed to stunt the replication of viruses, suggesting that this function dates back to an ancient ancestor of all the groups. Drosha is like the beta version of all antiviral defence systems, tenOever says.
tenOever speculates that RNAse III proteins originally helped bacteria to maintain their own RNA, and that bacteria later deployed the proteins against the genetic material of viruses. He points out the occurrence of RNAse III proteins in immune responses throughout the tree of life. For instance, some CRISPR systems, a virus-fighting response in archaea and bacteria, include RNAse III proteins. Plants and invertebrates deploy the proteins in RNAi. And although vertebrates rely on interferons for viral control, this study now shows that Drosha still chases after viruses, in the same way a pet Golden Retriever a dog bred to retrieve waterfowl fetches a stick as if it were a fallen duck.
Donald Court, a geneticist at the National Cancer Institute in Frederick, Maryland, calls the finding cool, but he doesnt buy the evolutionary scenario. RNAse III is involved in many things, in almost all domains of life, he explains. He sees no reason to think that one antiviral system evolved into the next. For instance, he says, the fact that one CRISPR system includes RNAse III whereas others dont suggests that the proteins were probably deployed acquired independently and not inherited.
Its a really intriguing story, and the data are good, but youre talking about processes that happened over millennia so its hard to know whether its true, says Bryan Cullen, a virologist at Duke University in Durham, North Carolina. Cullen predicts that the paper will prompt researchers who study RNA and infectious diseases to test tenOevers hypothesis. The immune system has been under tremendous pressure to evolve as viruses overcome defences, and this paper suggests that RNAse III has played an important role in that evolution, he says. Its like what the Red Queen said to Alice in Through the Looking-Glass: you have to keep running to stay in one place.
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Chimpanzee Interactions Lead To New Clues About Human Evolution – Paste Magazine
Posted: at 11:19 am
Signs of altruism selfless concern for others have been seen in chimpanzees, giving scientists cause to believe that this could be the basis of modern-day human cooperation.
Until this point, it has been difficult to pinpoint such behavior in animals closest to humans evolutionary makeup, as anything akin to selflessness had only been noted in rats in the past. However, in a recent experiment, it appeared that chimps would be willing to give up a treat if it meant that another unrelated chimp could be helped. In addition, it was found that chimps in the wild would risk going on patrols and standing guard even for those not of their own kin.
As Science Magazine reported, the first study was formulated around a sharing game that required the chimps be put into pairs and given options for receiving or not receiving treats. After this, one chimp was trained to give up their treat completely, while the second chimp had the option to simply eat their own treat or pull a rope and reward the both of them. At least 75% of the time, the second chimp would pull the rope, rewarding both of them and showing appreciation for the first chimp whod given its treat for the pure reason of that chimp having taken a risk.
To take the experiment one step further, researchers wanted to see if the chimps would pay their partners back simply just for having been shown kindness and giving up their treat in the first place. Results showed that the chimps did, in fact, feel compelled to frequently reward the first chimp for its perceived selflessnesseven at their own expense, as reported by Proceedings of the National Academy of Sciences (PNAS).
Though nothing is definitive yet, some researchers believe that this could be the first key to unlocking the psychological phenomenon that compels humans to cooperate with large, diverse communities or determine what it is that makes them reject that kind of cooperation.
Top photo by foshie / Flickr, CC BY 2.0
Natalie Wickstrom is a freelance writer based in Athens, Georgia. She most likely wrote this piece to the tune of a movie score whilst chewing gum.
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Darwinism Will Fix the Investment Industry – Bloomberg
Posted: at 11:18 am
The Financial Conduct Authority concluded its two-year investigation into the U.K. asset management industry by ordering investment firms to provide customers with an "all-in fee." It's a welcome attempt to eliminate the hidden costs that undermine people's efforts to save for their old age. Far more effective than an increase in regulation, however, is the financial Darwinism already wreaking change on the industry.
The FCA move, announced Wednesday, obliges fund managers to tell investors how much they charge for managing assets, as well as how much is paid to intermediaries and an estimate of transaction costs. While knowing what the fees are is clearly important, achieving lower fees is even more essential to delivering better returns that will let pensioners retire comfortably.
British fund managers oversee almost 7 trillion pounds ($9 trillion) of assets, including more than 1 trillion pounds for U.K. retail investors and about 3 trillion pounds for institutional investors including pension funds. Almost three-quarters of the money is invested in active funds, which charge an average fee of 0.9 percent of assets under management, compared with just 0.15 percent levied on passive funds.
As things stand, customers aren't getting value for money from active funds, according to the FCA. "There is no clear relationship between charges and the gross performance of retail active funds in the U.K.," it said. "There is some evidence of a negative relationship between net returns and charges. This suggests that when choosing between active funds, investors paying higher prices for funds, on average, achieve worse performance."
The FCA calculates that, after fees, a typical low-cost passive fund would deliver almost 25 percent more in returns than an active fund over a 20-year investment horizon, assuming it matched the performance of the benchmark U.K. FTSE All-Share index. Once transaction costs are included, that outperformance of passive versus active investment soars to almost 45 percent.
Yet the growth of passive funds is already driving fees down across the industry -- and there's more to come. A survey published this week by State Street Corp. showed the vast majority of industry players expect more downward pressure on fees in coming years.
Under Pressure
Looking ahead to the next five years, to what extent do you agree or disagree with the statement that fee compression in the asset management industry will intensify?
Source: State Street industry survey of more than 200 asset managers, more than half of which manage more than $10 billion
As a result, 76 percent of the funds surveyed anticipate more consolidation in the industry, as my Bloomberg News colleague Sarah Jones reported earlier this week. Mergers and acquisitions are seen as an "essential strategy" for survival, especially for smaller managers, the State Street survey showed.
Aberdeen Asset Management Plc, for example, is merging with Standard Life Plc to create the U.K.'s biggest active fund manager. Aberdeen suffered about $85 billion of net outflows in the past two years, and it has seen a drop in the fees it can charge.
Getting Cheaper
Aberdeen's blended average management fee
Source: Company filings
In its interim report in November, the FCA highlighted that asset managers "have consistently earned substantial profits" in recent years, with an average profit margin of about 36 percent since the start of the decade. Little wonder, then, that U.K. fund management firms have outperformed the broader stock market since the financial crisis.
Fund Managers Outperform
Source: Bloomberg
Those days of outperformance may be drawing to a close, and not just because of increased regulatory scrutiny. The rise of cheap exchange-traded funds continues apace; active funds will have to fight harder for market share, by lowering fees as well as proving to investors that they really can outperform their benchmarks on a consistent basis. Darwinism, not tighter rules, will produce a healthier asset management industry.
This column does not necessarily reflect the opinion of Bloomberg LP and its owners.
To contact the author of this story: Mark Gilbert in London at magilbert@bloomberg.net
To contact the editor responsible for this story: James Boxell at jboxell@bloomberg.net
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UK police to embrace IoT in age of ‘Digital Darwinism’ – The Internet of Business (blog)
Posted: at 11:18 am
A report published today by UK technology association techUK and the Centre for Public Safety explores how police forces can address the challenges and embrace the opportunities associated with the IoT.
The report,Policing and the Internet of Things, provides recommendations on how UK police forces can evolve with the fast-moving world of technology, particularly IoT, to create a digitally skilled police force.
Law enforcement officers in the UK have already begun to embrace emerging technologies, such as drones, for fighting crime. A growing number of officers are also using wearable cameras on the beat these days, while at least one crime scene investigation unit is already working on taking digital forensics from smart devices. However, more work is needed.
According to the report, with fraud and cyber crime now heading the list ofthe UKs top criminal offences, the growth of the IoT and the increasing number of devices connected to the internet means that the way police forces operate needs to change.
Not only have new risks been created, such as the deployment of ransomware onto devices, but more traditional crimes can now be committed online, targeting large numbers of people from almost anywhere in the world, it says.
Currently, online fraud is the most common crime in the country, but a joint report from the National Crime Agency and the National Cyber Security Center suggests that IoT-related crimes may soon become more frequent.
In light of the changing nature of crime, thereport recommends six incremental steps that police forces can take to address both the challenges and the opportunities of IoT.
To address the challenges presented by the IoT, they should:
To maximize the opportunities, meanwhile, they should:
Read more:Dubai rolls out Robocop to fight crime
The report has been endorsed by a number of senior police officers, includingAssistant Chief Constable Richard Berry, chief officer lead on the Digital Investigations and Intelligence Programme for the National Police Chiefs Council. Commenting on the report, he said:
The digital environment presents a number of challenges for public safety and the prevention and detection of crime. Police forces across the country have already adapted locally and there are many pockets of good practice. However, digital challenges can be different to those previously familiar to many in policing.
Working in new partnerships will help the Police Service discover and respond to threats and opportunities better and, in particular, closer working with industry will be critical. In order to fight crime in the digital age, it is vital that police have a good understanding of market capabilities. It will be important to ensure a regular exchange of ideas is facilitated, for police and industry to work collaboratively in responding to new crime and security issues.
This report sets out six incremental steps, which will help police forces meet the challenges presented and harness the opportunities available. Beyond this, I hope this report sparks discussion and debate for how we, as the Police Service can rise to the challenges of Digital Darwinism.
Read more:Ransomware disables connected hotel door system in Austria
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Growing robotics industry helps drive development in Pittsburgh – Pittsburgh Post-Gazette
Posted: at 11:18 am
Pittsburgh Post-Gazette | Growing robotics industry helps drive development in Pittsburgh Pittsburgh Post-Gazette Pittsburgh's growing robotics industry is helping to drive development and the demand for space in the Strip District and other East End neighborhoods, at times pushing rents even higher than they are in the best Downtown offices. That's the conclusion ... |
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