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Daily Archives: June 23, 2017
Vacation without Children – Childfree Getaways – TripSavvy
Posted: June 23, 2017 at 6:24 am
You're finally alone, ready to start your vacation. You turn to your beloved, about to speak. But then... "WAAAAH!" Suddenly, the sounds of silence are punctuated by a fretful, crying baby -- and the child is wailing as if it may not stop until it reaches college age.
When one travels, this happens all the time....in airports, on trains, planes, in restaurants, even in hotels with thin walls. Peace of mind is shattered by ear-piercing cries from OPBs (Other People's Babies).
What can you do?
Even if you have children, love kids, or are planning to start a family, you shouldn't have to spend a romantic vacation surrounded by the sticky-fingered set. The good news is, you don't have to. There are plenty of places that offer vacations without children; you just have to be selective.
Many all-inclusive resorts such as Sandals, SuperClubs, and Iberostar Grand Hotelsrestrict guests under age 16 or 18 -- so any immature people you may encounter on a vacation at such properties will be emotionally, rather than chronologically, immature.
Also, numerous fine inns, especially those furnished with treasured antiques, do not accept youngsters.
I don't know of any cruise line that restricts children, but if you want to avoid the little darlings, your best bet is a river cruise. More expensive than ocean cruises, they have zero facilities for children and tend to attract an older crowd.
(The one exception is AmaWaterways, which partners with Disney on a few sailings and is launching some custom-built ships for family travelers.)
On an ocean cruise, sailing a longer itinerary to distant ports at times other than summer and school breaks certainly cuts down on the likelihood you will encounter toddlers to teens.
Large cruise ships are starting to make concessions to adults:
I've spoken with many hoteliers and they tell me the best times to travel are what they call the "romance months" of May and September when kids are in school and couples season, which begins after Labor Day and ends before Thanksgiving. Personally, I've found October and early June relatively childfree times to travel as well. Also, immediately before a major holiday, such as the first two weeks in November or in February before spring break is a safe bet.
The term "family-friendly" is a red flag for me and should be for others who'd rather not vacation among children. If you book such a resort, expect children to be seen and heard throughout your stay.
We once took advantage of a Valentine's Weekend package at a family-friendly resort expecting a reprieve from the shrieks of infants, but we were out of luck.
That's because it coincided with President's Day weekend. And further to the consternation of childfree couples, new parents towed newborns along on what was intended to be a romantic interlude. One of the contributors to this site calls it "stroller shock."
Still, some multi-generational resorts do make a concerted effort to keep romantic couples and rambunctious families separate. The more upscale a place you select, the more likely it will have facilities that segregate children from grown-ups. Most hotel spas are off-limits to kids, for example, and better hotels and cruise lines feature adults-only pools. Among them:
Beware of hotels that have adults-only swim hours, though: While you won't have to put up with screams and splashing, you will be swimming in the same water where diapers may have dipped earlier.
Let the resort manager know how much you appreciate being in a serene, childfree space. The more you patronize places that cater exclusively to adults, the better it will be for everyone who likes to unwind without the presence of children.
Now if Disney would only make one day a month for adults on vacation without children, we'd be delighted.
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Political Correctness Presents A Challenge For Progressives – The Daily Caller
Posted: at 6:24 am
A whole lot of sound and fury has been made over political correctness. Its impossible to avoid talking about it, given its important role in the culture wars.
The old conservative yarn about political correctness is that its a leftist tool to suppress free speech. It accomplishes this by conditioning political discourse according to the constantly evolving rules and mercurial sensibilities of the left. This set-up skews the conversation from the outset in favor of the left. In this sense, political correctness has mostly been bad for the right so far.
Political correctness has doubtless played a major role in transforming our society according to the progressive program, and it continues to be the lefts major weapon in the culture wars. But how long can this advantage last?
Because of the fragile sensibilities of progressives, the culture wars have become, increasingly, a battle about speech rather than ideas. And this is starting to be bad for progressives. A tool that was meant to give them an edge is turning on them, and making them look out-of-touch and foolish.
The thing about odd speech is that it excites our amusement involuntarily. Lewis Carrolls Jabberwocky is funny because its all nonsense. There is something inherently funny about nonsensical bullshit.
When leftists butcher language to make reality conform to their ideas, the results are often ridiculous and difficult for outsiders to take seriously. SJW talk has been the butt of internet jokes for a while now, long enough to almost stop being funny altogether. Once upon a time, it was edgy and original to satirize the odd lingo popularized on Tumblr to describe confused young people who didnt receive enough attention from their parents growing up. There was something funny about those non-binary conforming non-GMO eating otherkin because the language seemed innocuous.
Its not funny anymore because it has become obvious that the left was never joking. Recently, Cambridge University tutors were told to stop using the word genius because of its sexist assumptions. Too often, genius has been used to describe brilliantly inventive men; therefore, the term genius is offensive to women.
To observers outside this strange bubble, this linguistic revisionism is pretentious, confusing, and simply ridiculous. It does nothing but push people away.
Political correctness is not new, but there is a growing feeling, not only on the right but outside the extreme-left campus bubble generally, that it didnt used to be this crazy. It only seems new because it has reached such an intensity of ridiculousness as to impress itself as something completely original. We are free-floating in a whole new world of linguistic and logical possibilities. In this world, it is possible at one and the same time to be a radical feminist and a devout Muslim; race is a social construct, but whites are inherently guilty for past injustices; and cisgendered people, the normative group, are expected to treat transgendered people like the new normative group. Most people identify with their biological sex, so it goes without saying that most people would balk at being prompted to give their preferred gender pronoun. Only in the vacuum-sealed world of academia could a question like this make any sense.
This system of ideas, if it can be called that, has no internal logic because it is not based on time-honored common sense. We have become unmoored from the traditions that Westerners accepted for generations to make sense of the world, and in doing so, we have discarded common sense.
The left has become reliant on political correctness to conceal the illogic of this system. Open dialogue is threatening to the left because it risks exposing their ideology as illogical and indefensible.
Outside the campus leftist bubble, people in the real world arent taken in by this Panglossian junk.
All it does is hurt the left in the end. Jon Ossoffs electoral loss has demonstrated better than any recent election could that the left needs to rethink how it reaches the electorate. A platform based on political correctness and antipathy towards the President wont do.
Worse, political correctness brings down political discourse by making it all about speech and feelings rather than ideas. Part of having a productive conversation is having clear ideas. Every philosophy undergrad knows this. How is it even possible to have a productive discussion when the ideas arent at the forefront of the discussion? When the terms to signify those ideas are constantly evolving?
Political correctness has been helpful to the left so far, but it will only hurt the progressive cause in the long run. If progressives dropped the language games, the constant speech policing, and the histrionic hurt parades, they might well lose some support, initially. But if they want to stay in touch with the electorate, they will have to, at some point, reflect, develop a better strategy for reaching people, and come down to earth. Maybe, then, theyll start winning again.
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Political Correctness Presents A Challenge For Progressives - The Daily Caller
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Relatives of eugenics victims opt not to appeal to NC Supreme Court – Winston-Salem Journal
Posted: at 6:23 am
Relatives of eugenics victims have opted not to appeal to the N.C. Supreme Court a ruling that denies some of them the ability to inherit payment as heirs.
An N.C. Court of Appeals panel ruled June 6 that eugenics victims seeking compensation from the state had to be alive on June 30, 2013, for their heirs to qualify for payment following a relatives death.
The Winston-Salem Journal series on eugenics in 2002, Against Their Will, brought awareness to the states program, which sterilized about 7,600 people before it ended in 1974.
The three-judge panel unanimously upheld the denials by the N.C. Industrial Commission related to compensation established by the Republican-controlled General Assembly in 2013.
The June 30, 2013, date was set in the law, which created a $10 million pool for compensation payments.
Our clients have decided not to seek further review by the N.C. Supreme Court, Elizabeth Haddix, senior staff attorney for UNC Center for Civil Rights, said Thursday.
Although the forced sterilization of their loved ones hurt them personally and impacted their lives forever, their goal has always been to honor their loved ones, whose most fundamental rights were violated by the states 40-year eugenics program.
They have honored them with these appeals, Haddix said.
At least 213 victims are considered by the commission to have qualified for compensation, and they received two partial checks $20,000 in October 2014 and $15,000 in November 2015.
A third and final payment is to be made after all appeals have been decided. It is not clear whether that stage has been reached.
Lawsuits were filed by the estates of three eugenics victims Hughes, Redmond and Smith, whose first names were not listed in the filings. The plaintiffs claimed the deadline for qualification was unconstitutional on its face because it arbitrarily denied compensation to the heirs of some victims while allowing compensation to others.
The appellate judges said in their ruling that state law does not treat heirs of living victims differently than it treats heirs of deceased victims. Instead, it said, heirs of victims are treated differently than the victims themselves.
The commission denied the claims in April and May 2015. The Appeals Court ruled in February 2016 that it lacked the jurisdiction to address the constitutional challenge.
In March, the state Supreme Court sent the case back to the Appeals Court to consider the constitutional challenge.
The panel ruled June 6 we cannot agree that the state law violated the plaintiffs rights to equal protection under the law.
Victims who, before June 30, 2013, were determined to be qualified and have a vested interest in compensation would have their compensation rights passed on to heirs.
Qualified victims were required to submit compensation forms to the commission by June 30, 2014, and 780 of a potential 2,000 living victims did.
The panel lists 250 claims as having been approved by the commission, with a handful awaiting final resolution on appeal.
At that rate, the compensation per approved claim would be in the $40,000 range, about $10,000 short of the recommended goal in the initial eugenics compensation legislation.
There is nothing in the preamble indicating that the General Assembly intended to compensate the heirs of individuals who had been sterilized under the authority of the eugenics board, according to the panel ruling.
In 2002, Gov. Mike Easley apologized for the sterilizations, but it took another decade for lawmakers to set up the compensation program.
In October 2016, President Barack Obama signed a law preventing any such compensation from being used to deny need-based assistance to the victims. The bipartisan legislation was introduced by U.S. Sen. Thom Tillis (R-N.C.), who led the N.C. compensation program while state House speaker.
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Relatives of eugenics victims opt not to appeal to NC Supreme Court - Winston-Salem Journal
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A photographic history of Finland – warts and all | Yle Uutiset | yle.fi – YLE News
Posted: at 6:23 am
A man photographing a sea of demonstrators on Senate Square in Helsinki, during Finland's general strike in March, 1956. Image: U. A. Saarinen
The National Museum's photo exhibit The Public and the Hidden Finland is structured around six themes: education, war, race, equality and democracy, society's relationship with nature as well as community.
The exhibit's photographs were taken from the National Board of Antiquities' vast archive of some 15 million images.
The above photo depicts a man taking a photograph of a sea of demonstrators on Senate Square in Helsinki, during Finland's general strike in March, 1956.
The strike, which involved some half a million workers across the country, brought Finland's industry and traffic to a standstill for 19 days. The movement was sparked by government reforms of salaries and price regulations the previous year, which led to severe price hikes on daily necessities like milk and even rent. The cost of living rose by some seven percent.
History repeated itself somewhat, if for different reasons, in the early 1990s. The photo above depicts a demonstration by the unemployed in front of Finnish Parliament in March 1993. At that point, Finland was in one of the worst economic crises in its history - even worse than the depression of the 1930s.
The exhibit also looks at the topic of race in Finland's history. Eugenics is the set of beliefs and practices popular in the 1930s based on the idea of improving the genetic material of the population by means that would now be viewed as brutal, discriminatory or racist. Finland had its share of eugenics enthusiasts, and in the 1930s laws were introduced which sanctioned forced sterilisations [mainly of women]. At the time, all four Nordic countries, including Finland, adopted some form of eugenics laws.
In the 1920s and 30s some scientists claimed that the Finnish "race" descended from Mongolia - not primarily from Europe. But other researchers who rejected the assertion travelled the country in search of specimens of "perfect Finns," often photographing them to prove the genetic superiority of the Finnish people.
The above shot, taken in 1925, features a scantily-clad Paavo Nurmi, the legendary Finnish runner known as the Flying Finn. Nurmi was presented as the ultimate - even supreme - Finnish specimen of athletic prowess.
Finland's prosperity was still quite far off when the above photo was taken in 1923. Three children crouched on a cobblestone sidewalk on the west coast town of Raahe were not simply playing - they at work, building the road.
This more recent photo shows a homeless person huddled in the meagre shelter of the Taxpayers Association of Finland's entryway in Helsinki on May Day 2015. Finns typically mark May Day with trade union marches and speeches throughout the country.
The exhibit opened at the National Museum in Helsinki last weekend and runs until the middle of January 2018.
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A photographic history of Finland - warts and all | Yle Uutiset | yle.fi - YLE News
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Turkish schools to stop teaching evolution, official says – The Guardian
Posted: at 6:20 am
The secular opposition has long argued that the government of Recep Tayyip Erdoan is pursuing a covert Islamist agenda contrary to the republics founding values. Photograph: AP
Evolution will no longer be taught in Turkish schools, a senior education official has said, in a move likely to raise the ire of the countrys secular opposition.
Alpaslan Durmu, who chairs the board of education, said evolution was debatable, controversial and too complicated for students.
We believe that these subjects are beyond their [students] comprehension, said Durmu in a video published on the education ministrys website.
Durmu said a chapter on evolution was being removed from ninth grade biology course books, and the subject postponed to the undergraduate period. Another change to the curriculum may reduce the amount of time that students spend studying the legacy of secularism.
Critics of the government believe public life is being increasingly stripped of the secular traditions instilled by the nations founder, Mustafa Kemal Atatrk.
The secular opposition has long argued that the government of Recep Tayyip Erdoan is pursuing a covert Islamist agenda contrary to the republics founding values. Education is a particularly contentious avenue, because of its potential in shaping future generations. Small-scale protests by parents in local schools have opposed the way religion is taught.
There is little acceptance of evolution as a concept among mainstream Muslim clerics in the Middle East, who believe it contradicts the story of creation in scripture, in which God breathed life into the first man, Adam, after shaping him from clay. Still, evolution is briefly taught in many high school biology courses in the region.
The final changes to the curriculum are likely to be announced next week after the Muslim Eid or Bayram festival at the end of the fasting month of Ramadan. The draft changes had been put forth for public consultation at the beginning of the year.
The subject of evolution in particular stirred debate earlier this year after Numan Kurtulmu, the deputy prime minister, described the process as a theory that was both archaic and lacking sufficient evidence.
Reports in Turkish media in recent weeks, based on apparent leaks of school board meetings, have also predicted a diminished role in the curriculum for the study of Atatrk, and an increase in the hours devoted to studying religion. Durmu said that a greater emphasis would be placed on the contributions of Muslim and Turkish scientists and history classes would move away from a Euro-centric approach.
The changes were based on a broad public consultation in which parents and the public played a key role, he said.
The Islamist-secularist debate is just one of a series of divides in a country that two months ago narrowly approved a referendum granting President Erdoan broad new powers.
Many in the religiously conservative element of the presidents support base admire his piety and see his ascension as a defeat of the elite White Turks a westernised elite that used to dominate the upper echelons of society and was accused of looking down with disdain on poorer, more religiously inclined citizens.
The secular opposition worries that the president and his party are reshaping Turkish society and clinging to neo-Ottoman ideals that see Turkey as the vanguard of a greater Islamic nation.
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Turkish schools to stop teaching evolution, official says - The Guardian
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Review: In ‘Food Evolution,’ Scientists Strike Back – New York Times
Posted: at 6:20 am
The scientific method is under siege, and not just from naysayers who dismiss climate change or fear vaccines. G.M.O.s genetically modified organisms and the crops they enable have become another field of battle.
Directed by Scott Hamilton Kennedy, Food Evolution hopes to demystify G.M.O.s and points to successes like Hawaiian papayas and Ugandan bananas, which were saved from devastating viruses. And while it gives opponents their say, the film rebuts their arguments, including reports that suggest G.M.O.s lead to a rise in farmers suicide rates and an increase in pesticide use. (The response to the first: correlation is not causation; to the second, yes, but those pesticides are far less toxic.)
A preview of the film.
The film also speaks with food journalists (including Michael Pollan, a contributing writer to The New York Times Magazine) as well as farmers who have benefited from the technology. And if trust is an issue, Neil deGrasse Tyson, perhaps the most credible public scientist on the planet, is its narrator.
The documentary acknowledges the gorilla in the garden: Monsanto, a leading exponent of modification, is one of the most-hated companies in the world. There are many reasons Monsanto raises hackles, Dr. Tyson acknowledges, but to be concerned about the safety of their G.M.O.s is to be misinformed.
The food industry recruits scientists to speak on its behalf, but in press notes and email correspondence, the films producers say no funding came from any Big Ag company or lobbying group. Food Evolution was commissioned by the nonprofit Institute of Food Technologists, and the filmmakers retained creative control.
With a soft tone, respectful to opponents but insistent on the data, Food Evolution posits an inconvenient truth for organic boosters to swallow: In a world desperate for safe, sustainable food, G.M.O.s may well be a force for good.
Director Scott Hamilton Kennedy
Stars Raoul Adamchak, Charles Benbrook, Tamar Haspel, Mark Lynas, Emma Naluyima
Running Time 1h 32m
Genre Documentary
Food Evolution Not rated. Running time: 1 hour 32 minutes.
A version of this review appears in print on June 23, 2017, on Page C7 of the New York edition with the headline: G.M.O.s May Not Be an Enemy.
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Review: In 'Food Evolution,' Scientists Strike Back - New York Times
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Flight demands may have steered the evolution of bird egg shape … – Science News Magazine
Posted: at 6:20 am
The mystery of why birds eggs come in so many shapes has long been up in the air. Now new research suggests adaptations for flight may have helped shape the orbs.
Stronger fliers tend to lay more elongated eggs, researchers report in the June 23 Science. The finding comes from the first large analysis of the way egg shape varies across bird species, from the almost perfectly spherical egg of the brown hawk owl to the raindrop-shaped egg of the least sandpiper.
Eggs fulfill such a specific role in birds the egg is designed to protect and nourish the chick. Why theres such diversity in form when there's such a set function was a question that we found intriguing, says study coauthor Mary Caswell Stoddard, an evolutionary biologist at Princeton University.
Previous studies have suggested many possible advantages for different shapes. Perhaps cone-shaped eggs are less likely to roll out of the nest of cliff-dwelling birds; spherical eggs might be more resilient to damage in the nest. But no one had tested such hypotheses across a wide spectrum of birds.
Stoddard and her team analyzed almost 50,000 eggs from 1,400 species, representing about 14 percent of known bird species. The researchers boiled each egg down to its two-dimensional silhouette and then used an algorithm to describe each egg using two variables: how elliptical versus spherical the egg is and how asymmetrical it is whether its pointier on one end than the other.
Next, the researchers looked at the way these two traits vary across the bird family tree. One pattern jumped out: Species that are stronger fliers, as measured by wing shape, tend to lay more elliptical or asymmetrical eggs, says study coauthor L. Mahadevan, a mathematician and biologist at Harvard University.
Story continues after graphic
By examining the eggs of 1,400 species (each species average egg is represented on this scatterplot by apale orange dot), researchers found that the shape of bird eggs is determined by two variables: ellipticity and asymmetry. Dark orange dots mark species highlighted as examples.
Mahadevan cautions that the data show only an association, but the researchers propose one possible explanation for the link between flying and egg shape. Adapting to flight streamlined bird bodies, perhaps also narrowing the reproductive tract. That narrowing would have limited the width of an egg that a female could lay. But since eggs provide nutrition for the chick growing inside, shrinking eggs too much would deprive the developing bird. Elongated eggs might have been a compromise between keeping egg volume up without increasing girth, Stoddard suggests. Asymmetry can increase egg volume in a similar way.
Testing a causal connection between flight ability and egg shape is tough because of course we cant replay the whole tape of life again, says Claire Spottiswoode, a zoologist at the University of Cambridge who wrote a commentary accompanying the study. Still, Spottiswoode says the evidence is compelling: Its a very plausible argument.
Santiago Claramunt, associate curator of ornithology at the Royal Ontario Museum in Toronto, isnt convinced that flight adaptations played a driving role in the evolution of egg shape. Streamlining in birds is determined more by plumage than the shape of the body high performing fliers can have rounded, bulky bodies he says, which wouldnt give elongated eggs the same advantage over other egg shapes. He cites frigate birds and swifts as examples, both of which make long-distance flights but have fairly broad bodies. There's certainly more going on there.
Indeed, some orders of birds showed a much stronger link between flying and egg shape than others did. And while other factors like where birds lay their eggs and how many they lay at once werent significantly related to egg shape across birds as a whole, they could be important within certain branches of the bird family tree.
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NASA’s new assignments: Find aliens, prove evolution – WND.com
Posted: at 6:20 am
The National Space and Aeronautics Administration has done some amazing things for the United States over the years: the initial short flights into space, then the longer orbiting missions, the moon visits, the space station and even unmanned trips to every sidewalk in the solar system.
But now it has some new goals: Find aliens.
And prove evolution.
And while the agency is at it, its staff members should identify the origins of life.
Thats according to the new and very religious marching orders the agency was given just weeks ago.
The Atlantic explained just what developed.
The truth about evolution is all found in the WND Superstore, in Evolution: The Grand Experiment, Volume 1, Icons of Evolution, The Lie: Evolution Intelligent Design vs. Evolution, Incredible Creatures that defy Evolution II and more.
On March 21 of this year, both parties in Congress and the Trump administration made a change to a federal document that amounted to only a few words, but which may well change the course of human history.
Every few years, Congress and the administration pass a NASA Authorization Act, which gives the U.S. Space Agency its marching orders for the next few years. Amongst the many pages of the 2017 NASA Authorization Act (S. 422) the agencys mission encompasses expected items such as continuation of the space station, building of big rockets, indemnification of launch and reentry service providers for third party claim and so on.
But in this years bill, Congress added a momentous phrase to the agencys mission: the search for lifes origins, evolution, distribution, and future in the universe. Its a short phrase, but a visionary one, setting the stage for a far-reaching effort, that could have as profound an impact on the 21st century as the Apollo program had on the 20th.
At the NASA Watch bog, Keith Cowing noted the law itself states, The administrator shall enter into an arrangement with the National Academies to develop a science strategy for astrobiology that would outline key scientific questions, identify the most promising research in the field, and indicate the extent to which the mission priorities in existing decadal surveys address the search for lifes origin, evolution, distribution, and future in the universe.
Atlantic speculated on the meaning of the change, noting it will include a new emphasis on the question of whether there are other life forms in the universe.
In the last decade we have made enormous advances in the field of exoplanet studies. Telescopes on the ground have become sensitive enough to discern the faintest stellar wobbles, as orbiting planets tug gently against the gravitational bonds. With the National Science Foundations Atacama Large Millimeter Array, and the Hubble Space Telescope, we have peered into interstellar clouds where new planets are forming and have detected the presence of all the elements necessary for life.
It noted that just last February, a nearby star system was confirmed to have seven planets orbiting, three of which lie with the stars Goldilocks zone, making them potentially habitable.
There have been multiple reports of planets that possibly could sustain life. Whats thought to be needed for life water and energy sources have been located even on Saturns moon, Enceladus.
And just last June, the New York Times said, Yes, there have been aliens.
Even so, the mystery still remains about life on earth, and the report places its faith in the still-unexplained idea that somehow, somewhere, sometime, something turned from inanimate matter into living tissue.
On its own.
Every worm on a deep sea vent, or cactus eking out an existence in the high Andres, every human who hunted on the plains or stood on the moon owes their existence to a single chance meeting of two cells that learned to get along, it continued.
There is a possibility, and even a statistical probability, that life exists on some planet other than earth, reports say.
But at Inverse, bloggers charged Congress sneakily told NASA to, well, find aliens.
And the move is being viewed by those in the faith community as the federal governments endorsement of an effort to prove the biblical creation narrative false.
The work already had begun.
The Atlantic reported: NASA has been putting in place all the necessary building blocks to make the Search for Life possible. NASAs James Webb Space Telescope (JWST), due to launch in late 2018, will begin following up on recently discovered exoplanets, searching for the fingerprints of life, gases that scientists believe can only exist in the presence of living organisms. And NASA and private industry have embarked on ambitious new rockets capable of carrying probes and landers to Europa [one of Jupiters moons which is encrusted in ice], and launching future telescopes capable of finding and characterizing continents and oceans on Earth-like planets. Soon, they will be able to send (human) geologists and biologists to Mars.
At least the marching orders are a change from what ex-President Barack Obama wanted from NASA.
He wanted the agency to be a Muslim feel-good outreach.
According to the Telegraph, Charles Bolden, a retired United States Marines Corps major-general and former astronaut, said in an interview with al-Jazeera that NASA was not only a space exploration agency but also an Earth improvement agency.'
Bolden said: When I became the NASA administrator, he [Obama] charged me with three things. One, he wanted me to help re-inspire children to want to get into science and math; he wanted me to expand our international relationships; and third, and perhaps foremost, he wanted me to find a way to reach out to the Muslim world and engage much more with dominantly Muslim nations to help them feel good about their historic contribution to science, math, and engineering.
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NASA's new assignments: Find aliens, prove evolution - WND.com
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Researchers use supercomputers to study snake evolution, unique … – Phys.Org
Posted: at 6:20 am
June 22, 2017 by Aaron Dubrow A Burmese python superimposed on an analysis of gene expression that uncovers how the species changes in its organs upon feeding. Credit: Todd Castoe
Evolution takes eons, but it leaves marks on the genomes of organisms that can be detected with DNA sequencing and analysis.
As methods for studying and comparing genetic data improve, scientists are beginning to decode these marks to reconstruct the evolutionary history of species, as well as how variants of genes give rise to unique traits.
A research team at the University of Texas at Arlington led by assistant professor of biology Todd Castoe has been exploring the genomes of snakes and lizards to answer critical questions about these creatures' evolutionary history. For instance, how did they develop venom? How do they regenerate their organs? And how do evolutionarily-derived variations in genes lead to variations in how organisms look and function?
"Some of the most basic questions drive our research. Yet trying to understand the genetic explanations of such questions is surprisingly difficult considering most vertebrate genomes, including our own, are made up of literally billions of DNA bases that can determine how an organism looks and functions," says Castoe. "Understanding these links between differences in DNA and differences in form and function is central to understanding biology and disease, and investigating these critical links requires massive computing power."
To uncover new insights that link variation in DNA with variation in vertebrate form and function, Castoe's group uses supercomputing and data analysis resources at the Texas Advanced Computing Center or TACC, one of the world's leading centers for computational discovery.
Recently, they used TACC's supercomputers to understand the mechanisms by which Burmese pythons regenerate their organsincluding their heart, liver, kidney, and small intestinesafter feeding.
Burmese pythons (as well as other snakes) massively downregulate their metabolic and physiological functions during extended periods of fasting. During this time their organs atrophy, saving energy. However, upon feeding, the size and function of these organs, along with their ability to generate energy, dramatically increase to accommodate digestion.
Within 48 hours of feeding, Burmese pythons can undergo up to a 44-fold increase in metabolic rate and the mass of their major organs can increase by 40 to 100 percent.
Writing in BMC Genomics in May 2017, the researchers described their efforts to compare gene expression in pythons that were fasting, one day post-feeding and four days post-feeding. They sequenced pythons in these three states and identified 1,700 genes that were significantly different pre- and post-feeding. They then performed statistical analyses to identify the key drivers of organ regeneration across different types of tissues.
What they found was that a few sets of genes were influencing the wholesale change of pythons' internal organ structure. Key proteins, produced and regulated by these important genes, activated a cascade of diverse, tissue-specific signals that led to regenerative organ growth.
Intriguingly, even mammalian cells have been shown to respond to serum produced by post-feeding pythons, suggesting that the signaling function is conserved across species and could one day be used to improve human health.
"We're interested in understanding the molecular basis of this phenomenon to see what genes are regulated related to the feeding response," says Daren Card, a doctoral student in Castoe's lab and one of the authors of the study. "Our hope is that we can leverage our understanding of how snakes accomplish organ regeneration to one day help treat human diseases."
Making Evolutionary Sense of Secondary Contact
Castoe and his team used a similar genomic approach to understand gene flow in two closely related species of western rattlesnakes with an intertwined genetic history.
The two species live on opposite sides of the Continental Divide in Mexico and the U.S. They were separated for thousands of years and evolved in response to different climates and habitat. However, over time their geographic ranges came back together to the point that the rattlesnakes began to crossbreed, leading to hybrids, some of which live in a region between the two distinct climates.
The work was motivated by a desire to understand what forces generate and maintain distinct species, and how shifts in the ranges of species (for example, due to global change) may impact species and speciation.
The researchers compared thousands of genes in the rattlesnakes' nuclear DNA to study genomic differentiation between the two lineages. Their comparisons revealed a relationship between genetic traits that are most important in evolution during isolation and those that are most important during secondary contact, with greater-than-expected overlap between genes in these two scenarios.
However, they also found regions of the rattlesnake genome that are important in only one of these two scenarios. For example, genes functioning in venom composition and in reproductive differencesdistinct traits that are important for adaptation to the local habitatlikely diverged under selection when these species were isolated. They also found other sets of genes that were not originally important for diversification of form and function, that later became important in reducing the viability of hybrids. Overall, their results provide a genome-scale perspective on how speciation might work that can be tested and refined in studies of other species.
The team published their results in the April 2017 issue of Ecology and Evolution.
The Role of Supercomputing in Genomics Research
The studies performed by members of the Castoe lab rely on advanced computing for several aspects of the research. First, they use advanced computing to create genome assembliesputting millions of small chunks of DNA in the correct order.
"Vertebrate genomes are typically on the larger side, so it takes a lot of computational power to assemble them," says Card. "We use TACC a lot for that."
Next, the researchers use advanced computing to compare the results among many different samples, from multiple lineages, to identify subtle differences and patterns that would not be distinguishable otherwise.
Castoe's lab has their own in-house computers, but they fall short of what is needed to perform all of the studies the group is interested in working on.
"In terms of genome assemblies and the very intensive analyses we do, accessing larger resources from TACC is advantageous," Card says. "Certain things benefit substantially from the general output from TACC machines, but they also allow us to run 500 jobs at the same time, which speeds up the research process considerably."
A third computer-driven approach lets the team simulate the process of genetic evolution over millions of generations using synthetic biological data to deduce the rules of evolution, and to identify genes that may be important for adaptation.
For one such project, the team developed a new software tool called GppFst that allows researchers to differentiate genetic drift - a neutral process whereby genes and gene sequences naturally change due to random mating within a population - from genetic variations that are indicative of evolutionary changes caused by natural selection.
The tool uses simulations to statistically determine which changes are meaningful and can help biologists better understand the processes that underlie genetic variation. They described the tool in the May 2017 issue of Bioinformatics.
Lab members are able to access TACC resources through a unique initiative, called the University of Texas Research Cyberinfrastructure, which gives researchers from the state's 14 public universities and health centers access to TACC's systems and staff expertise.
"It's been integral to our research," said Richard Adams, another doctoral student in Castoe's group and the developer of GppFst. "We simulate large numbers of different evolutionary scenarios. For each, we want to have hundreds of replicates, which are required to fully vet our conclusions. There's no way to do that on our in-house systems. It would take 10 to 15 years to finish what we would need to do with our own machinesfrankly, it would be impossible without the use of TACC systems."
Though the roots of evolutionary biology can be found in field work and close observation, today, the field is deeply tied to computing, since the scale of genetic materialtiny but voluminouscannot be viewed with the naked eye or put in order by an individual.
"The massive scale of genomes, together with rapid advances in gathering genome sequence information, has shifted the paradigm for many aspects of life science research," says Castoe.
"The bottleneck for discovery is no longer the generation of data, but instead is the analysis of such massive datasets. Data that takes less than a few weeks to generate can easily take years to analyze, and flexible shared supercomputing resources like TACC have become more critical than ever for advancing discovery in our field, and broadly for the life sciences."
Explore further: Team proposes new model for snake venom evolution
More information: Audra L. Andrew et al, Growth and stress response mechanisms underlying post-feeding regenerative organ growth in the Burmese python, BMC Genomics (2017). DOI: 10.1186/s12864-017-3743-1
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Researchers use supercomputers to study snake evolution, unique ... - Phys.Org
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Are aliens more likely by design than black holes? – SYFY WIRE (blog)
Posted: at 6:19 am
Darwinism extends far beyond Earths atmosphere, something Darwin himself could probably never even imagine. Cosmological natural selection (CNS) is based on its biological doppelganger, but evolutionist Michael Price has taken it where no theory has gone before.
Theoretical physicist Lee Smolin had previously suggested that black holes are adaptations of CNS, just as claws or night vision are adaptations born of biological natural selection. He theorized that life emerges from the selection of black holes because universes supposedly self-replicate through them, so those with more gravitationally superpowered star corpses have the advantage. Price has turned Smolins theory inside out to propose that it is actually intelligent life that is more likely to be an adaptation of CNS that results in universes replicating themselvesaka CNS with intelligence.
"Living organisms are the least entropic, that is, the most complexly ordered and improbable entities known to exist," Price insists in defense of his reverse theory that sees life as an adaptation rather than a by-product of universe replication.
The same biological natural selection that generates complex order and decelerating entropy is believed to have a mirror image in the cosmos. Cosmological natural selection depends on the existence of intelligent life because it is much less likely to spawn at random than a black hole, not to mention the most complex thing we know of and the one entity in the cosmos least prone to decay and degeneration.
Even before natural selection shot off into space, Darwin was onto something. Bio-natural selection is entropys worst enemy because it creates organisms rather than destroying them. Everything crawling, flying or swimming around Earth today is here because they run on genes with the most potential for survival. Not having an immune system resistant enough to killer microbes or teeth deadly enough to demolish prey meant your bloodline would perish, while having these survival traits meant your DNA would also survive. Universes with intelligent life (as compared to those without that cosmological boost) are assumed to level up the same way.
This doesnt necessarily send Smolins theory into the chasm of a black hole. While intelligent life may be the ultimate CNS adaptation, black holes could still be the reason universes beget other universes.
CNS may be the ultimate primary cause of cosmological order, just as BNS is the ultimate primary cause of biological order, said Price. In other words, BNS and CNS may together be ultimately responsible for much of the order that we observe in the universe.
(via Phys.org)
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Are aliens more likely by design than black holes? - SYFY WIRE (blog)
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