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Daily Archives: June 17, 2017
Researchers send DNA on sequential building mission – Phys.org – Phys.Org
Posted: June 17, 2017 at 1:46 pm
June 16, 2017 by James Devitt A team of scientists has developed a method to create structures whose building blocks are a millionth of a meter in size by encoding DNA with assembly instructions. In a series of experiments, the researchers mixed four "flavors" of droplets (yellow, orange, green, and blue), each coated with different DNA, but which do not bind. They then added a new droplet (red), which specifically binds to the orange droplet and activates it for the next step in the assembly. This process spurs the creation of a droplet chain in a pre-determined order (red-orange-yellow-green-blue). Credit: Yin Zhang
A team of scientists has developed a method to create structures whose building blocks are a millionth of a meter in size by encoding DNA with assembly instructions.
The work, described in the journal Nature Communications, manipulates the sequencing of DNA to offer an intricate and innovative approach to synthesize materials at the most fundamental level.
"Sequential programmability is a powerful addition to the self-assembly toolbox that will prove useful in creating the tiniest of materials," explains Yin Zhang, the paper's lead author and a graduate student at New York University's Center for Soft Matter Research. "It brings some of the advantages of the biological use of controlled sequential assembly using molecules, nucleic acids, and proteins to a new design scale."
NYU physics professors Paul Chaikin and Jasna Brujic as well as Nadrian Seeman, an NYU professor of chemistry, co-directed the research.
Both natural and human-made structures are built sequentiallyfrom cells to skyscrapers. Like Russian nesting dolls, assembly takes place on the inside before commencing on the outside.
However, when making materials on a micrometer scale, or about one hundredth of the width of a strand of human hair, scientists face challenges unfamiliar to engineers and manufacturers.
While many methods have been adopted to manipulate such tiny particles, these approaches all have notable shortcomings in assembling structures.
The NYU team sought to overcome these hurdles with a new approach: encode the instructions of assembly within the building blocks and let these building blocks self-organize into a prescribed structure in a pre-determined sequence.
To do so, it deployed different strands of DNA, each coated on a droplet of oil in water, where they then "talked" to each other through DNA-mediated interactions. Specifically, the scientists placed four "flavors" of dropletslabeled B, C, D, and Einto water. They then added an "initiator" droplet, A, which began the sequencing process. Here, the DNA strand on A initiates a chain of events in which it displaces one of the paired strands on B, whose released strand moves to activate C, the next droplet in the sequence, and so on. The process results in a droplet chain, ABCDE.
Explore further: Chemists color world of 3-D crystals with advances in self-assembly
The wide reach of corrosion, a multitrillion-dollar global problem, may someday be narrowed considerably thanks to a new, better approach to predict how metals react with water.
A team of scientists has developed a method to create structures whose building blocks are a millionth of a meter in size by encoding DNA with assembly instructions.
A team of researchers at Sungkyunkwan University in South Korea has developed a type of adhesive patch that works under a variety of conditions including underwater. In their paper published in the journal Nature, the team ...
Javier Vela, scientist at the U.S. Department of Energy's Ames Laboratory, believes improvements in computer processors, TV displays and solar cells will come from scientific advancements in the synthesis of low-dimensional ...
A team of researchers at the University of Pennsylvania is gaining new insight into the smart materials used in ultrasound technology. While forming the most thorough model to date of how these materials work, they have found ...
Researchers have developed a solar paint that can absorb water vapour and split it to generate hydrogen - the cleanest source of energy.
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Genome pioneer John Sulston enters elite club – BBC News – BBC News
Posted: at 1:46 pm
BBC News | Genome pioneer John Sulston enters elite club - BBC News BBC News Sir John Sulston is elevated to the Companion of Honour in the Queen's birthday list. Birthday Honours: gongs for Cambridge genome scientist John ... Cambridge scientists among those honoured by Queen | Anglia ... |
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This Study is Forcing Scientists to Rethink the Human Genome – Gizmodo
Posted: at 1:46 pm
The more data, the better, right? When it comes to genetics, it turns out that might not be the case.
As both genetic sequencing has gotten cheaper and computerized data analysis has gotten better, more and more researchers have turned to what are known as genome-wide association studies in hopes of sussing out which individual genes are associated with particular disorders. The logic here is simple: If you have a whole lot of people with a disease, you should be able to tell what genetic traits those people have in common that might be responsible. This thinking has resulted in an entire catalogue of hundreds of research studies that has shed light on the genetic origins of diseases such as type 2 diabetes, Parkinsons disease, Crohns disease, and prostate cancer, while helping fuel the rise of personalized medicine.
Now, though, a new analysis calls the entire approach into question.
Writing in the journal Cell, a group of Stanford University geneticists write that such large studies are likely to produce genetic variants with little bearing on the disease in questionessentially false positives that confuse the results.
Intuitively, one might expect disease-causing variants to cluster into key pathways that drive disease etiology [the causes of disease], they write. But for complex traits, association signals tend to be spread across most of the genomeincluding near many genes without an obvious connection to disease.
Their analysis suggests an intriguing new way of viewing the genome in which nearly every gene impacts every other gene. Instead of a system in which you can plug and play different variables to affect different results, its a complex, inter-related network. They call this the omnigenic model.
Their work has broad, sweeping implications for the entire field of genetics. First off, that all those big, expensive genome-wide association studies may wind up being little more than a waste of time because they turn up genetic variants that, while perhaps interconnected to the disease, may not actually point to a viable target for things like drug therapy.
Indeed, genes that often seem related to diseases have stumped researchers in terms of the role they actually play in the condition. In the paper, for example, the Stanford researchers re-analysed a 2014 study of 250,000 people which found nearly 700 DNA variants linked to heightbut only 16 percent of these variants had anything to do with a persons height. In the paper, the Stanford researchers suggest that the impact of each variant has a teeny impact on height.
Far from solving a problem though, this new research merely opens up an entirely new line of questioningand shows us once again, that we may not know nearly as much as we thought we did.
[Cell]
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Are genome-wide association studies fundamentally flawed? – MedCity News
Posted: at 1:46 pm
MedCity News | Are genome-wide association studies fundamentally flawed? MedCity News From 5,000 to 10,000 to one million and beyond. The scale of so-called genome-wide association studies (GWAS) has grown at a voracious pace over the last decade. And there's no sign the initiatives are slowing down. As sequencing and data analysis ... |
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Eczema on Your Scalp? Here’s How to Ease the Symptoms – Health.com
Posted: at 1:45 pm
In addition to your body, hands, and face, eczema can also plague the scalp, usually in a condition known as seborrheic dermatitis. There is some disagreement among experts about whether or not seborrheic dermatitis should be considered a form of chronic eczema or a separate skin condition, although the National Eczema Association considers it to be a type of eczema. (Eczema is a general term that includes a variety of conditions that causered, inflamed skin.)
"Seborrheic dermatitis is a common form of chronic eczema on the scalp associated with a fungi," says Gil Yosipovitch, MD, professor of medicine at the University of Miami Miller School of Medicine and author of Living With Itch ($19; amazon.com).
In addition to the scalp, seborrheic dermatitis may also affect parts of the face (such as the nose), the back, ears, or center of the chest. It strikes parts of the body with many oil-producing (sebaceous) glands, leading to symptoms such as redness, flakes, and patches of greasy, swollen-looking skin.
Unlike atopic dermatitis, a chronic form of eczema that is thought to be caused byan abnormal immune reaction,seborrheic dermatitisdoesn't usually cause severeitching. However, you can be diagnosed with bothseborrheic dermatitisand atopic dermatitis at the same time.
RELATED: 5 Reasons Why You Have an Itchy Scalp
Experts aren't sure exactly what causes seborrheic dermatitis. Genetics might make you more susceptible, and hormones, stress, or other triggers may lead to an overactive immune response that causes symptoms like red, painful, flaky skin to appear. A fungus called malassezia also plays a role. (This same fungus has been linked to dandruff, which is considered to be a mild form of scalp seborrheic dermatitis.)
Seborrheic dermatitis can usually be treated with medicated shampoos that contain tar, zinc pyrithione, salicylic acid, selenium sulfide, or ketoconazole. Leave the shampoo on for five or 10 minutes before rinsing it off. At first, you may want to use it several times a week, then use it once a week if symptoms improve.
Ross S. Levy, MD, chief of dermatology at Northern Westchester Hospital Center in Mount Kisco, N.Y. and an associate clinical professor of medicine at Mount Sinai School of Medicine in New York City, tells us you can also have a separate type of eczema without the presence of seborrheic dermatitis. "It can be difficult to differentiate," he says. This type is contact dermatitis, and is triggered by a reaction to an irritating substance on the scalp (think: hair dyes or scented hair products).
Short-term use of topical corticosteroids made for the scalp may help. "They come in solution form. You can put a drop into your scalp, or more," says Dr. Levy. "Its more like a gel, almost like a mousse. Those are good for purely calming down the inflammation."
But for both contact dermatitis and seborrheic dermatitis, it's important not to itch your scalp: hair loss can occur with either condition.
"If theres enough irritation you can get hair loss," Dr. Levy cautions. "You can scratch and irritate your scalp, enough that can kill off the hair so you can lose hair."
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Internet censorship in India is on the rise – CNNMoney
Posted: at 1:43 pm
The nation has shut down the internet in various regions 20 times in the first five months of this year, according to a report from Human Rights Watch. Four of those blackouts have taken place this month, all in states where violent protests took place.
That represents a dramatic uptick from last year, when 31 shutdowns were recorded in total, and an even greater increase since 2012 -- which saw only three shutdowns.
The Indian government did not respond to a request for comment on the report, but has argued in the past that restricting access is sometimes necessary to prevent social media rumors from fueling violence.
Related: Can Theresa May use tech to stop terror attacks?
The disputed and conflict-ridden region of Kashmir, for example, has seen 33 shutdowns in five years.
"The lack of transparency and failure to explain these shutdowns only furthers the perception that they are meant to suppress nonviolent reporting and criticism of the government," said Meenakshi Ganguly, South Asia director for Human Rights Watch.
While the Indian government doesn't have its own internet-blocking apparatus like China's "Great Firewall," it can order service providers to go offline. That power stems from a law written in 1973, which allows the government to impose various restrictions on the public to prevent everything from riots to "obstruction, annoyance or injury."
Related: A huge wave of new users is killing 4G speeds in India
India, which is often referred to as the world's largest democracy, has been called out for online censorship before.
A 2016 survey of internet freedom in 65 countries by U.S.-based think tank Freedom House gave India a score of 41. China, with a score of 88, came last. Estonia performed best with a score of 6.
In another report by the Brookings Institution last year, India tied for first place with Iraq for the highest number of internet shutdowns among 19 countries (including Saudi Arabia, Pakistan, Syria and North Korea).
Facebook also ranks the Indian government among the top countries asking it to censor content. The social media giant said in its latest Government Requests Report that India ordered 719 pieces of content to be restricted, lower only than Brazil, Turkey and Germany.
India topped Facebook's list for two straight years up to June 2015.
CNNMoney (New Delhi) First published June 16, 2017: 10:13 AM ET
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Adviser suspended after pro-Trump messages were edited out of high school yearbooks – Washington Post
Posted: at 1:43 pm
A New Jersey high school yearbook adviser has been suspended amid an investigation into censorship allegations overphotos and a quotation that were altered to remove references to President Trump, according to news reports.
Three students at Wall High School in central New Jersey noticed the changes in their yearbooks late last week, and their parents have since been calling for action.
Wall Township public schoolsSuperintendent Cheryl Dyer said last weekthat the district learned aboutan allegation of censorship and the possible violation of First Amendment rights and was investigating the matter. She told USA Todaylate Monday that the teacher, whom she would not name,was suspended pending further disciplinary action. NJ.com reported that the teacher has been suspendedindefinitely with pay while the district investigates the allegations.
Dyer did not immediately respond to a request for comment about the suspension. Its still unclear what role the teacher may have played in the yearbook alterations.
[Parents outraged after pro-Trump messages were edited out of this high schools yearbooks]
On picture day in October, one student,juniorWyatt Dobrovich-Fago, had worn a fleece vest with a Trump campaign logo, but it appeared to be cropped out in the yearbook. His sister, Montana, who was freshman-class president, was missing a Trump quote that was meant to appear beneath her photo. I like thinking big. If you are going to be thinking anything, you might as well think big, itread,according to CNN.
But perhaps the most blatant edit was to17-year-oldGrant BerardosTRUMP Make America Great Again! T-shirt, which was apparently altered in his yearbook photo to removethe Republican presidential nominees campaign slogan. In the yearbook, the high school junior appeared to be wearing a plain and simple, dark-colored T-shirt.
Grants father,Joseph Berardo, said in a Facebook post Monday night that he had met with the school administration earlier in the day and was informed that the teacher had been suspended.
There was a lapse in judgement and mistakes were made. I suspect there will be meaningful consequences, Berardo wrote.
I refuse to be censored although my son was, he added. Issues like these are too important to look the other way. HOWEVER, if we agree to talk instead of shout, I believe we can always find common ground.
Berardo earlier told The Washington Post that school pictures were sent home to the studentsfamilies after the electionand that there did not seem to be any issue with Grants portrait.
In fact, he said, Grants picturewasused as hisschool identificationphoto.
He was just really surprised; it was the first election he ever took an interest in, he said of his son. His question was, Is it okay? Did someone do something here that they shouldnt have done? Thats why Im pursuing it.He said he wants his son to understand that althoughthese are your teachers and administrators, there are still things youre permitted to do throughthe Constitution.
Dyer, the superintendent, previouslysaid in a statement, Two parents have notified the school district of ways in which the attire of their children was altered in yearbook photos. Further, there are claims that comments or quotes offered for inclusion in the yearbook were not published. References to and support of President Trump were involved in each of these incidents.
There is nothing in Wall Township High Schools student dress code that would prevent a student from expressing his or her political views, or support for a political figure, via appropriate clothing and attire, she said. Indeed, the administration applauds students for becoming involved in politics, making their voices known, and taking an active part in our democracy.
The district has not identified the suspended adviser, but Berardo said it was Susan Parsons, who has worked for the district for 15 years, according to her course website. Thecourse sitestates that Parsons oversees Yearbook 1, 2 and 3, as well as other technology courses such as digital media, Web page design, computer repair and digital animation and gaming.
Parsons could not immediately be reached Tuesday for comment and an email sent to her schoolemail address came back as undeliverable. But she told the New York Post, We have never made any action against any political party.
Shewould not say who made the edits, according to the New York Post.
Read more:
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Where do Virginias Democratic gubernatorial candidates stand on school choice and other education issues?
Nonprofit sues Education Dept. for release of information on campus sex-assault investigations
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Grab one of 2,000 Post Human W.A.R beta keys and start playing … – PCGamesN
Posted: at 1:41 pm
Humanity has died out and all that's left on Earth are the mutated animals and household robots we left behind. This is how you're introduced to the world of Post Human W.A.R, a turn-based strategy game that pits sentient vacuum cleaners against tracksuit monkeys against each other in warfare.
There are, in fact, three different factions - or groups - to choose from in Post Human W.A.R. They're all battling to decide the fate of the world now that humans have been wiped out. The mutated animals are hoping to destroy everything - they're pretty angry about the state they've been left in - the robots are hoping to protect humanity's heritage, and finally the monkeys are hoping to pick back up where the humans left off, becoming the new dominant species.
Once you've picked which side you'll serve, you then enter battle with the others, which requires you to pick units and spread them across a honeycomb grid - positioning your fighters to be the most effective is crucial. While fighting, either in single-player or online against strangers, you'll also need to make use of the environment, as well as react to the enemy's bluffs - adding a psychological level to the game's tactics.
If you want to get involved in the beta of Post Human W.A.R right now, you can. Just enter via our widget below and unlock your key.
When you've grabbed your code redeem via Steam. Simply click the Add a Game button at the bottom left of the Steam client window, and Activate a Product on Steam. Follow the instructions, download the game, and get playing!
If you like our giveaways and want to be kept in the loop about them, head over and give thePCGamesN Facebook page a likeorfollow us on Twitter.
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Elon Musk Just Published His Plan to Colonize Mars – Futurism
Posted: at 1:40 pm
A New Plan
They say everythings sweeter the second time around, and that seems to be the casefor SpaceXs plans to colonizeMars. Last year, Musk unveiled his plans to colonize the Red Planet and make it fit for human habitation. Now, that version of the plan has been published and madeavailable for freewith a few notable updates.
In the paper, the focus is on affordability, as that is the primary factor in making life on Mars a reality. As Musk notes, You cannot create a self-sustaining civilization if the ticket price is $10 billion per person. In order for it to be viable, Musk asserts that the cost should be about $200,000equivalent to the median price of a house in the United States. In the paper, Musk outlines the steps he considers essential to ensuring this relative affordability.
But this is just the beginning.Musk posted a tweet today hinting that this version one is already being reviewedand version 2 is on its way.
According to Musk, the version one has one fundamental flaw, which is the cost of developing and operating giant rockets. While SpaceX has been specializing on reusable rockets, getting to Mars would still be costly due to the size of the rockets needed. According to V1 of the plan, getting to Mars depends on a reusable rocket-and-spaceship tandem, which Musk has called the Interplanetary Transport System (ITS). Reducing the costs to developing the ITS is crucial, especially since Musk himself has already put a cap on how much a trip to Mars should be.
Musk asserts that he envisions 1,000 or soITS spaceships, each of which are carrying 100 or more people, leaving Earth orbit during Mars windows, the point in time when Earth and Mars align favorably, which happens once every 26 months.
Outlining the importance of making this information freely available, New Space editor-in-chief Scott Hubbard asserts that publishing this paper provides not only an opportunity for the spacefaring community to read the SpaceX vision in print with all the charts in context, but also serves as a valuable archival reference for future studies and planning.
There is a huge amount of risk. It is going to cost a lot,Musk wrote. There is a good chance we will not succeed, but we are going to do our best and try to make as much progress as possible. By giving everyone access to this information, our chances of success are greatly improved.
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Head Transplant Doctor Reports Successful Repair of Spinal Cord … – Futurism
Posted: at 1:40 pm
In BriefA head transplant doctor claims to have made advance towardrealizing the medical procedure, but the scientific communityremains skeptical. The team claims to have used a proprietary"glue" to repair the severed spines of rats and achieved fullrecovery. Head Transplants?
Sergio Canavero, a man who has made the goal of his lifes work to transplant a human head onto a donor body, is claiming a success. He and his team have reported seemingly positive results from a technique called the Gemini Protocol. They used the protocol to repair severed spinal cords in rats, and their findings indicate that their methodology works across the board.
The researchers severed thespinal cords of 15 rats. Nine then received the actual Gemini Protocol, while the remaining six served as controls.
After the team severed the spinal cords, they applied adrenaline and a cooled saline to reduce bleeding. The rats treated with the experimental process received a polyethylene glycol (PEG) substance Canavero simply refers to as glue, which he says repairs and seals nerve cells in damaged spinal cords. The wounds were closed and the rats received antibiotics for three days.
Fourteen of the 15 rats survived for a month following the operation. According to the researchers, the experimental rats treated with PEG mixture recovered motor function steadily and were about to walk again by day 28. In fact, two of them were basically normal by that time.
However, most in the scientific community joined by most in the gaming community for totally different reasons are as highly skeptical about these alleged outcomes as they have been all along.
Scientists are doubtful for several reasons. First, the team didnt describe their methods well enough for other researchers to be sure about them. Case Western Reserve University Professor of Neurosciences Jerry Silver said in an interview with Newsweek that its not clear whether they severed only the dorsal spinal chord or the entire spinal chord.
He also points out an overall lack of evidence: they show no evidence for regeneration. There is no histology [the microscopic study of tissue structure], which is the only way to assess what is really going on here, Silver added.
Moreover, the characterization and scoring of motor function in the experimental rats is, according to Silver, unrealistic. The study reported that two of the treated animals recovered nearly normal locomotor skills (scoring of 19 and 20 points out of a possible 21 total) and that the treated rats had average a score of 12, which means that, on average, they could take multiple weight-bearing steps.
[This is] unbelievable, Silver said in the interview. Too good to be true in my opinion, which mandates that these results will have be independently verified and properly analyzed before this work can be accepted as scientifically valid.
Gamers are also skeptical because this appears to many to be a viral marketing scheme for Metal Gear Solid. The games creator and Canavero both deny this.
The team is now moving on to experimentation on dogs apparently horrifying many potential consumers is not a concern for them. They hope this next stage will provide indisputable proof that the technique works across the board. The first human head transplant remains scheduled in December of this year; the patient will be a Chinese national.
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