Daily Archives: June 7, 2017

So, you’ve bought Bitcoin. Now what? – GQ.com

Posted: June 7, 2017 at 4:53 pm

So, youve bought Bitcoin (or another cryptocurrency) and hey! its shot up in value. Good for you. But what do you do with your digital money now? If youve made a serious profit, you might be wary of leaving it on an exchange such as Coinbase or stashing it in an online wallet (after all, North Korean hackers have reportedly stolen almost $90,000 of Bitcoin in the last two years). The most secure alternative is to take your currency offline altogether with a hardware wallet. This is a purpose-built, secure device for cold-storing the private keys that allow you to spend your digital currency. Two of the most popular are the Ledger Nano S and the Trezor, both of which employ open-source code (meaning that even if the companies were to fold, the devices would not be rendered obsolete). We tested them both

The Ledger Nano S looks like a USB stick, except it comes with a tiny screen that means you can operate it independently of your computer (as otherwise it would be vulnerable to malware). The controls are pared back to two buttons on the top of the device, which are used for everything from scrolling through menus to entering your PIN.

Set-up is simple. On-screen instructions take you through configuring your PIN and randomly generating your passphrase. The passphrase is important. If you were to lose or break the device, you can restore your entire balance on a new Ledger by entering this 24-word phrase.

Next, you download a set of Chrome extensions: a main device manager, and wallets for the different currencies you hold. Ledger currently supports Bitcoin, Ethereum / Ethereum Classic, Ripple, Litecoin, Dogecoin, Zcash, Dash and Stratis. If you wish to send or receive currency you do so via these browser-based apps, and your Ledger will ask you to press buttons to confirm that you do indeed want to carry out that function. Without the Ledger plugged in, moving your currency is impossible.

Pros: This is a compact device that has found clever systems to make a two-button control system viable. It supports a multitude of currencies, and is the most affordable of the two hardware wallets on test.

Cons: The build quality on our model could have been better. The left-hand button often registered one click as two, and it encountered problems a number of times during setup, though we succeeded eventually.

61, ledgerwallet.com

The Czech-built Trezor which translates as vault in its native language has many similarities with the Ledger. It, too, has a screen that means you can use it to keep your money safe even on an infected computer, and operating it also comes down to two buttons. The set-up is similar as well its all about choosing a PIN and a 24-word passphrase that allows you to restore the device. How you interface with this dongle from your computer, however, is rather different.

Whereas the Ledger asks you to tap away on its buttons in order to input your PIN, the Trezor displays the numbers 1 - 9 in a random formation, and asks you to click the corresponding buttons on a digit-less pad displayed on your computer screen.

The Chrome app through which you control your Trezor and your wallets is slicker than the Ledgers. It involves opening fewer windows, and the visuals are rather more glossy though it essentially offers the same functionality. It feels like a more expensive product, and it is. The only downside is that, for now, it lacks support for currencies such as Ripple.

Pros: Higher production values, both in terms of software and hardware.

Cons: Fewer currencies supported.

76, trezor.io

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Bitcoin’s King Solomon Moment – Slate Magazine

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A bitcoin ATM in Barcelona in 2014.

Josep Lago/AFP/Getty Images

Back in early 2014, thanks to a confluence of digital malfeasance and wide-eyed optimism, bitcoin enjoyed a nice run in the headlines. Things have since quieted in the popular press, but venture capitalists, entrepreneurs, and speculators have continued to work toward the promise of a secure, fast, and cheap payment system that cuts out fee-hungry banks and credit card companies. Following Bitcoins lead, theyve built dozens of competing cryptocurrency systems, and while digital coins arent part of most peoples everyday lives today, its increasingly clear that they will be, sooner or later.

Bitcoin itself, however, wont necessarily be part of the future it has ushered in. A broad surge in cryptocurrency values pushed the original recipe north of $40 billion in late May, but a long-standing issue that limits the systems capacity has left it struggling to give users what it says on the tin: a cheap, quick way to move money. Because bitcoin is open-source and democratically managed, a huge number of stakeholders are wrangling over how to solve this scaling crisis, which hinges on an obscure technical parameter.

In response, the bitcoin community has split into two factions that tout mutually incompatible solutions while accusing each other of incompetence, conspiracy, self-aggrandizement, and generally being the devil. On March 17, more than two-dozen bitcoin marketplaces issued a joint letter warning that there is a very real possibility that a Bitcoin network split may occur in the future if the conflict isnt resolved. It was one of the first high-level acknowledgments that, just as it begins to fulfill its promise, Bitcoin could be torn in half.

The idea of a Bitcoin split, or the extremely personal infighting that has made it a possibility, would have seemed laughable just a few years ago. Then, a tight-knit crew of bitcoin pioneers gleefully nerded out over an arcane innovation with world-changing potential. At the heart of bitcoins radical promise is the so-called blockchain, essentially a ledger where transactions are recorded. But instead of some spreadsheet living on a single computer, the blockchain exists on thousands of servers worldwide that constantly monitor one anothers copies of the ledger. This makes the network essentially unhackablean astonishing achievement of computer science and economic engineering.

Since a still-anonymous creator introduced bitcoin in 2009, its central innovation has given birth to a diverse and thriving ecosystem. There are now dozens of other cryptocurrency systems, with names like Ethereum, Dash, and Ripple, many with more features than Bitcoin. Perceived instability in Bitcoin could eventually push investors and developers to these alternatives. But more profoundly, Bitcoins inability to solve its own problems would cast doubt on its core libertarian-democratic premise: that people dont need the government or banks to manage their currency.

If Bitcoin were to split, it will be because it was just too successful for its own good. Public interest and transaction volume has grown more or less steadily for the past five years, and the blocks that make up the blockchainbundles of about 2,000 transactions compiled every few minutesare getting very crowded. Some transfers can currently wait hours, even days, to go through.

Users can pay a fee to have their money moved first, through a bidding process that is becoming increasingly fierce. Before 2014, bitcoin transactions were effectively free. By October, users had to pay operators about 13 cents to get speedy resolution. Today, that average fee is closer to 50 cents. That removes some of bitcoins appeal as an alternative to, say, Visa, which charges merchants about 10 cents for small transactions or about $1 for the average swipe.

Almost everyone admits this is a problem, but bitcoiners are divided into two camps over how to solve it. One faction is led by Roger Ver, a very early funder of Bitcoin startups who has relentlessly proselytized for the technology since 2011. Among the cultish ranks of bitcoin boosters, Vers commitment and vision earned him the nickname Bitcoin Jesus. Now, he has taken up the banner of Bitcoin Unlimited, a solution to the scaling issue that would directly increase the codes limit on how much data a block can hold.

While this would make bitcoin faster and cheaper for users, critics say it would also make it more expensive to run a server. For this heresy, Vers enemies have rechristened him the Bitcoin Antichrist. One of his main allies, the Chinese server manufacturer Jihan Wu, has been similarly dubbed Jihad Wu, complete with a satirical Twitter account that paints him as an ISIS-style terrorist.

The main competing proposal is offered by Bitcoins central development team, Bitcoin Core, and is known as Segregated Witness, or SegWit. It would free up a smaller amount of space for transactions, while making it easier for secondary systems to handle smaller transactions outside of the main, super-secure blockchain. But it could leave bitcoin proper nearly useless for small transactions.

This may sound like a technical squabble among quislings. But the two solutions imply two fundamentally different visions of what bitcoina system that currently has a higher market value than Credit Suisseshould be. Those who support Vers vision of larger blocks want bitcoin to be a day-to-day, open payments network, usable to buy anything from a cup of coffee to a car. Those who support SegWit are more likely to see bitcoin as digital gold, a long-term store of value that wouldnt move around that much. That would leave fees high but make paying them less necessary, while relying more on secondary systems.

The two factions congregate on separate, opposing Reddit forums where they each tout their solution while meme-trolling the enemy. Each accuses the other of sockpuppetingusing fake social media accounts to create the impression of popular support. (And each side, of course, denies in engaging in such behavior.)

If Bitcoin were a company, youd expect the CEO to sort out his or her underlings petty backbiting. But Bitcoin has no leaders. Instead, the miners that run Bitcoins servers essentially vote on any proposed changes. For years, the consensus version of the software was distributed by the slowly rotating Bitcoin Core team and adopted with little controversy. Core had no official authority, but its expertise was broadly trusted.

But many miners have lost faith in Core, accusing it of moving too slowly to tackle the scaling issue. According to tracking site Blockchain.Info, a little more than 40 percent of miners are currently signaling their support for Bitcoin Unlimited, compared with only 30 percent signaling for SegWit. If more than 50 percent of miners were to support Bitcoin Unlimited, they could force a shift in the entire network. Ver, though, says he would like to see much more decisive margins of support before any changes are implemented, and SegWit requires support from 95 percent of miners before it can be activated.

With each faction so firmly entrenched, theres no sign things will sharply swing either way any time soon. But a smaller group of miners could branch off to form a separate network and an entirely new currency. This split, known as a hard fork, is what the exchanges that issued the March letter were planning for.

Not everyone thinks a hard fork would be a bad thing. Anthony Di Iorio was one of the founders of Ethereum, the most prominent system to innovate on bitcoins core ideas. Should there be a hard fork, he predicts, youre going to have better growth. [Users] will be able to decide. Competition is good. Ver, unsurprisingly, describes a fork as not a big problem at all.

But othersnaturallydisagree. Reggie Middleton is a financial analyst focused on cryptocurrency and runs the decentralized trading platform Veritaseum. A Bitcoin Unlimited fork would be destructive to the economic value of the [Bitcoin] network as a whole, he says, in part because the strength of any payments system hinges on its size.

Middleton is also concerned about Bitcoin Unlimiteds implications for bitcoins governance. Like Ver and most longtime bitcoin supporters, hes a staunch critic of government and corporate power, attracted to bitcoin because it promises to free currency from control by old regimes. But Bitcoin Unlimiteds larger blocks would require more computing power, storage, and network bandwidth to process, which could concentrate mining in fewer hands, making the system both less secure and less democratic.

Once you centralize it, says Middleton, you open it to threats. It would become like the banking system, which is basically greedy middlemen who stand between you and your money. For bitcoin die-hards, there is no greater slur than comparing something to a bank.

For bitcoin die-hards, there is no greater slur than comparing something to a bank.

Ver thinks this position is ridiculous. Bitcoin was once a true grassroots project, with ramshackle servers toddling along in peoples basements and dorm rooms. But the system has already become vastly more power-hungry: Ver points out that a single usable mining server, and its voting power, today costs $1,000 or more. In other words, bitcoin is still a radical political project, but its also big business, and its time to come to terms with that.

Jeff Garzik has a unique perspective on the public bloodletting. Before spending four years as part of the Bitcoin Core team, Garzik was a leader at Red Hat, which helped make the open-source Linux system digestible for corporate users. Someone had to play that insulating role, because it was common for Linuxs democratic community of developers to engage in ideological warfare over lines of code.

But Garzik says that even Linuxs biggest battles cant compare to the hate swirling around bitcoins block-size debate. While Linux fights might have broken out over engineering approaches, and early bitcoin debates revolved around ideology and theory, Garzik thinks something much less abstract is driving bitcoins current unrest: money.

At this point, more than $1.5 billion in venture capital has gone to support blockchain startups, and many have business models that would be affected by how the block-size problem is solved. Blockstream, which employs some Bitcoin Core developers, builds sidechains, the sort of secondary system that would be more in demand if bitcoin itself doesnt start accepting more transactions. On the other hand, theres BitPay, which has sold merchants the idea of bitcoin as a low-fee retail payment system, and for whom the strangled state of the bitcoin blockchain has been a serious headache.

Youre asking developers, in effect, to pick winners and losers in the market, says Garzik.Theres no right answer.

But there could be a wrong answer. A miscalculated change could disrupt bitcoins basic economics, a fine balance of computing costs, coin value, and network demand. And all of those competing blockchains are waiting for a mistake. If bitcoin were to recede, that will be sad for me, says Ver. If theres another iPhone thats better, thats sad for my old iPhone. But it means we get to use a better one. Ver has outlined this endgame scenario on the same portal that he established years ago as a friendly invitation to new bitcoin users. Bitcoin Jesus is now preaching about the looming bitcoin apocalypse.

The viciousness and intractability of the scaling fight could suggest a flaw at the heart of bitcoins core democratic ideals. Maybe, in the end, we really do need authority figures to make big decisionsespecially when theres money on the line. But Charlie Shrem, another early bitcoin entrepreneur who now supports the SegWit solution, focuses on the fact that the software has stood firm amid the chaos. Changes that can hurt the network cant happen easily. Its the same thing with changes that can make the network better. Its what makes the network strong. Its beautiful. His opponent, Ver, sees the same silver lining.

Its not surprising that the two would share a sanguine perspective on the chaos gripping their lifes work. Though nominally antagonists today, Shrem and Ver have a friendship rooted in years in the bitcoin trenchesVers first investment was in Shrems bitcoin payment startup. Shrem says Ver (along with a lot of other people who hate each other on the internet) will attend his upcoming wedding.

In the aftermath of the exchanges March letter, the tension over scaling has continued to ratchet up slowly. New proposals have attempted to break the standoff between Bitcoin Unlimited and SegWit, including one that some say subverts bitcoins basic decision-making process. A version of the SegWit solution was successfully activated on the bitcoin alternative Litecoin, demonstrating that its ready for the big leagues. But still, the deadlock holds, bitcoin is left with the slow and expensive status quo, and neither side is truly happy.

And maybe thats just what democracy looks like.

This article is part of Future Tense, a collaboration among Arizona State University, New America, and Slate. Future Tense explores the ways emerging technologies affect society, policy, and culture. To read more, follow us on Twitter and sign up for our weekly newsletter.

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Ask the Sketch Guy: Should I Finally Buy Some Bitcoin? – New York Times

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New York Times
Ask the Sketch Guy: Should I Finally Buy Some Bitcoin?
New York Times
To kick off things, Shawn Cook from San Diego asked a question about Bitcoin. (For an explainer on Bitcoin, see this article by Nathaniel Popper of The New York Times, who literally wrote the book on the topic.) His hipster friend is constantly bugging ...

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US bitcoin conman hit with $12m fine – BBC News – BBC News

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St. Joseph’s students make contact with Space Station astronaut – Long Island Catholic

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Ronkonkoma What started as a hobby for St. Joseph Schools technical director and technology teacher Jennifer Medordi, ended up taking her whole school to space as more than 300 people packed St. Josephs gym on May 22 to see a dozen students from the school speak directly to astronaut Jack Fischer on the International Space Station. The direct contact with the space station was the culmination to a school year that celebrated mans exploration of space, and the fascination people have had throughout time with the exploration and conquest of space.

Scroll down for gallery of photos

An amateur (HAM) radio operator,Medordi mentioned a program called ARISS, which is an acronym for Amateur Radio on the International Space Station, to Principal Richard Kuntzler and asked if she could pursue placement in the program for St. Josephs students. Jennifer explained that the ARISS program was a comprehensive program with suggested readings, hands-on assignments and other related work that gave students a broad historical, scientific and cultural perspective on space exploration Kuntzker said. I was intrigued by the idea, but because only about a dozen schools get chosen nationally each year to participate, I wasnt planning around the program just yet. That all changed when St. Joseph School was notified that they were just one of 14 schools nationally, and the only Catholic school, selected to participate during the 2016 2017 school year.

In her proposal, Ms. Medordi outlined the current STEM (Science, Technology, Engineering and Math) program already in place at St. Josephs and identified some cross-curricular opportunities they could take advantage of if selected. The initial meeting with the rest of the faculty at St. Josephs just blew me away, Medordi said. The teachers all enthusiastically embraced the concept and identified places where space exploration and radio communication could be embedded into all subjects, including Social Studies, English Language Arts, Music, Art and Religion.

Since the beginning of the school year students at St. Josephs have read books on space, listened to space inspired music, and have learned about radio waves and rocket trajectories. There have even been three teacher-designed Space Days with themes that have included Space History where they studied the Mercury, Apollo and Space Shuttle missions. Theyve learned about Living in Space where they did activities that simulated space living and exercises for living in microgravity. And they projected what the future might hold on Colonizing Mars day. On HAM Radio Day, Medordi and her father, Paul Janson set up radio operations in the school allowing students to make contacts across the tri-state area to better understand HAM radio.

The May 22 contact with the International Space Station was led by 12 students from the school who became Space Ambassadors by qualifying via an essay contest. The Ambassadors and the rest of their classmates put together a list of 20 questions that represented the things that they wanted to know, and that hopefully hadnt been asked before. Some of the questions included: - If you could go back in time and say something to your pre-astronaut self, what would it be? - Do you perceive time differently in space? - How does your view of Earth impact your perspective on humanity and how has the experience affected your faith?

Story continues after slideshow

Photos by Gregory A. Shemitz

Father Mike Reader, pastor of St. Josephs Parish, noted the profound changes weve seen in society in the 50 years since the Christmas Eve reading from the Book of Genesis during Americas Apollo 8 mission, and contrasted that with todays global cooperative international effort. He noted that the International Space Station is the largest non-war international collaboration in history with 16 countries collaborating, and he thanked Medordi for lighting the flame of space exploration in the school, and for all of the rest of the teachers in the school for fanning that flame.

The ARISS Program is a once-in-a-lifetime experience made possible by the Amateur Radio community and NASA. Space Ambassadors from St. Joseph School included:Shane Bellino, Dominic Marando,Alicia Soler , Manuel Kittel,Lauren Avilla, Ralph Silvestre,Cadence DePersio, Logan Danna,Aaron Tabigue, Rohan Douglas,Joseph Fardella Jr. and Alexandra Buttonow

As a result of the ARISS Program and St. Joseph staffs efforts the students now have a new appreciation of space science and many have expressed a desire to pursue careers in science and technology fields stated Medordi. That is the ultimate goal of the ARISS Program, to turn students on to the wonders of science and technology.

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Two Great Views of the Intl. Space Station – WOODTV.com (blog)

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WOODTV.com (blog)
Two Great Views of the Intl. Space Station
WOODTV.com (blog)
There are many views of the International Space Station here in early June. Here's the complete schedule here. Two views really stand out. The first is tonight at 10:49 pm. The station appears in the northwest sky and moves up close to overhead, then ...

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UK astronaut Tim Peake’s second trip to the International Space … – Quartz

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Quartz
UK astronaut Tim Peake's second trip to the International Space ...
Quartz
Britain's fight with Europe has far-reaching implications, stretching all the way into outer space. In January, the UK announced that it would send its star astronaut ...

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How genetic engineering helped reduce cotton’s environmental footprint – Genetic Literacy Project

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Cottons environmental footprint is much less noticeable today than was the case in the early 1960s, thanks largely to science and technology.

Ryan Kurtz, director of agricultural research, Cotton Incorporated, says the highly successful Boll Weevil Eradication Program, genetic engineering, innovations in tillage, and changes in farm size and efficiency combined to reduce cottons impact on the environment over the past 35 years.

[Kurtz] said cotton farming has evolved from horses to robots and drones. Weve seen great strides in reduced soil loss, water use, and pesticide use.

Biotechnology now protects plants from insect damage, Kurtz said. Herbicide tolerant varieties also allow a more efficient weed management system. Cotton farmers also reduce energy consumption because of biotech, he added.

Genetic engineering has improved varieties in other ways. We have more water efficient varieties, which improves on a plant already known for drought tolerance.

[T]he success of the Boll Weevil Eradication Program and the introduction of Bt cotton revolutionized insect control in cotton. At one time, cotton farmers in some areas were spraying as many as 15 times in a season. The average was seven. Following boll weevil eradication, the average dropped to five, and after Bt cotton was introduced the average dipped to two.

The GLP aggregated and excerpted this blog/article to reflect the diversity of news, opinion, and analysis. Read full, original post: Cottons effect on the environment continues to diminish

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Scientists are finding more genes linked to IQ. This doesn’t mean we can predict intelligence. – Vox

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Last month, researchers announced some astonishing findings in Nature Genetics: Theyd found 40 genes that play a role in shaping human intelligence, bringing the total number of known intelligence genes up to 52.

This study was a big deal because while weve known intelligence is largely heritable, we havent understood the specifics of the biology of IQ why it can be so different between people, and why we can lose it near the end of life.

The Nature Genetics study was a key early step toward understanding this, hailed as an enormous success in the New York Times.

And there are many more insights like this to come. The researchers used a design called a genome-wide association study. In it, computers comb through enormous data sets of human genomes to find variations among them that point to disease or traits like intelligence. As more people have their genomes sequenced, and as computers become more sophisticated at seeking out patterns in data, these types of studies will proliferate.

But theres also a deep uneasiness at the heart of this research it is easily misused by people who want to make claims about racial superiority and differences between groups. Such concerns prompted Nature to run an editorial stressing that the new science of genetics and intelligence comes to no such conclusions. Environment is crucial, too, Nature emphasized. The existence of genes for intelligence would not imply that education is wasted on people without those genes. Geneticists burned down that straw man long ago.

Also, nothing in this work suggests there are genetic difference in intelligence when comparing people of different ancestries. If anything, it suggests that the genetics that give rise to IQ are more subtle and intricate than we can ever really understand.

Were going to keep getting better at mapping the genes that make us smart, make us sick, or even make us lose our hair. But old fears and myths about genetics and determinism will rear their heads. So will fears about mapping ideal human genes that will lead to designer babies, where parents can pick traits for their children la carte.

To walk through the science, and to bust its myths, I spoke to Danielle Posthuma, a statistical geneticist at Vrije Universiteit in Amsterdam, who was the senior author on the latest Nature study.

Theres a simple understanding of genetics were all taught in high school. We learn, as Gregor Mendel discovered with pea plants, that we can inherit multiple forms of the same gene. One variation of the gene makes wrinkled peas; the other makes for round peas. Its true, but its hardly the whole story.

In humans, a few traits and illnesses work like this. Whether the bottom of your earlobes stick to the side of your face or hang free is the result of one gene. Huntingtons disease which deteriorates nerve cells in the brain is the result of a single gene.

But most of the traits that make you you your height, your personality, your intellect arise out of a complex constellation of genes. There might be 1,000 genes that influence intelligence, for example. Same goes for the genes that lead to certain disorders. Theres no one gene for schizophrenia, for obesity, for depression.

A single gene for one of these things also wont have an appreciable impact on behavior. If you have the bad variant of one gene for IQ, maybe your IQ score ... is 0.001 percent lower than it would have been, Posthuma says.

But if you have 100 bad variants, or 1,000, then that might make a meaningful difference.

Genome-wide association studies allow scientists to start to see how combinations of many, many genes interact in complicated ways. And it takes huge data sets to sort through all the genetic noise and find variants that truly make a difference on traits like intelligence.

The researchers had one: the UK Biobank, a library that contains genetic, health, and behavioral information on 500,000 Britons. For the study, they pulled complete genome information on 78,000 individuals who had also undergone intelligence testing. Then a computer program combed through millions of sites on the gene code where people tend to variate from one another, and singled out the areas that correlated with smarts.

The computer processing power needed for this kind of research this study had to crunch 9.3 million DNA letters from 78,000 people hasnt been available very long. But now that it is, researchers have been starting to piece together the puzzle that links genes to behaviors.

A recent genome-wide analysis effort identified 250 gene sites that predicted male pattern baldness in a sample of 52,000 men. (Would you really want to know if you had them?) And theres been progress identifying genes that signal risk for diabetes, schizophrenia, and depression.

And these studies dont just look at traits, diseases, and behavior. Theyre also starting to analyze genetic associations to life outcomes. A 2016 paper in Nature reported on 74 gene sites that correlate with educational attainment. (These genes, the study authors note, seem to have something to do with the formation of neurons.) Again, these associations are tiny the study found that these 74 gene variants could only explain 3 percent of the difference between any two people on what level of education they achieve. Its hardly set in stone that youll flunk school if you dont have these gene variants.

But still, they make a small significant difference once you start looking at huge numbers of people.

Its important to note that Posthumas study was only on people of European ancestry. Whatever we find for Europeans doesnt necessarily [extrapolate] for Asians or South Americans, [or any other group] she says. Those things are often misused.

Which is to say: The gene variations that produce the differences between Europeans arent necessarily the same variations that produce differences among groups of different ancestry. So if you were to test the DNA of someone of African origin, and saw they lacked these genes, it would be incredibly irresponsible to conclude they had a lower capacity for intelligence. (Again, there are also likely hundreds of more genetic sites that have something to do with intellect that have yet to be discovered.)

Posthumas work identifying genes associated with intelligence isnt about making predictions about how smart a baby might grow up to be. She doesnt think you can reliably predict educational or intelligence outcomes from DNA alone. This is all really about reverse-engineering the biology of intelligence.

Genes code for proteins. Proteins then interact with other proteins. Researchers can trace this pathway all the way up to the level of behavior. And somewhere along that path, there just might be a place where we can intervene and stop age-related cognitive decline, for instance, and Alzheimers.

We're finally starting to see robust reliable associations from genes with their behavior, she says. The next step is how do we prove that this gene is actually evolved in a disorder, and how does it work?

Understanding the biology of intelligence could also lead the way for personalized approaches to treating neurodegenerative diseases. Its possible that two people with Alzheimers may have different underlying genetic causes. Knowing which genes are causing the disease, then, you might be able to tailor the treatment, Posthuma says.

As more and more genome-wide studies are conducted, the more researchers will be able to assign people polygenic risk scores for how susceptible they might be for certain traits and diseases. That can lead to early interventions. (Or, perhaps in the wrong hands, a cruel and unfair sorting of society. Have you seen the movie Gattaca?)

And there are some worries about abusing this data, especially as more and more people get their genomes analyzed by commercial companies like 23&Me.

Many people are concerned that insurance companies will use it, she says. That they will look into people's DNA and say, Well, you have a very high risk of being a nicotine addict. So we want you to pay more. Or, You have a high risk of dying early from cancer. So you have to pay more early in life. And of course, that's all nonsense. Its still too complicated to make such precise predictions.

We now have powerful tools to edit genes. CRISPR/Cas9 makes it possible to cut out any specific gene and replace it with another. Genetic engineering has advanced to the point where scientists are building whole organisms from the ground up with custom DNA.

Its easy to indulge our imaginations here: Genome-wide studies are going to make it easier to predict what set of genes leads to certain life outcomes. Genetic engineering is making it easier to assemble whatever genes we want in an individual. Is this the perfect recipe for designer babies?

Posthuma urges caution here, and says this conclusion is far afield from the actual state of the research.

Lets say you wanted to design a human with superior intelligence. Could you just select the right variants of the 52 intelligence genes, and wham-o, we have our next Einstein?

No. Genetics is so, so much more complicated than that.

For one, there could be thousands of genes that influence intelligence that have yet to be discovered. And they interact with each other in unpredictable ways. A gene that increases your smarts could also increase your risk for schizophrenia. Or change some other trait slightly. There are trade-offs and feedback loops everywhere you look in the genome.

If you would have to start constructing a human being from scratch, and you would have to build in all these little effects, I think we wouldn't be able to do that, Posthuma says. It's very difficult to understand the dynamics.

There are about 20,000 human genes, made up of around 3 billion base pairs. We will never be able to fully predict how a person will turn out based on the DNA, she says. Its just too intricate, too complicated, and also influenced heavily by our environment.

So you could have a very high liability for depression, but it will only happen if you go through a divorce, she says. And who can predict that?

And, Posthuma cautions, there are some things that genome-wide studies cant do. They cant, for instance, find very, very rare gene variations. (Think about it: If one person in 50,000 has a gene that causes a disease, its just going to look like noise.) For schizophrenia, she says, we know that there's some [gene] variants that decrease or increase your risk of schizophrenia 20-fold, but they're very rare in the population.

And they cant be used to make generalizations about differences between large groups of people.

Last year, I interviewed Paul Glimcher, a New York University social scientist whose research floored me. Glimcher plans to recruit 10,000 New Yorkers and track everything about them for decades. Everything: full genome data, medical records, diet, credit card transactions, physical activity, personality test scores, you name it. The idea, he says, is to create a dense, longitudinal database of human life that machine learning programs can mine for insights. Its possible this approach will elucidate the complex interactions of genetics, behavior, and environment that put us at risk for diseases like Alzheimers.

Computer science and biology are converging to make these audacious projects easier. And to some degree, the results of these projects may help us align our genes and our environments for optimal well-being.

Again, Posthuma cautions: Not all the predictions this research makes will be meaningful.

Do we care if we find a gene that only increases our height or our BMI or our intelligence with less than 0.0001 percent? she asks. It doesn't have any clinical relevance. But it will aid our scientific understanding of how intellect arises nonetheless.

And thats the bottom line. The scientists doing this work arent in it to become fortune tellers. Theyre in it to understand basic science.

What most people focus on, when they hear about genes for IQ, they say: Oh, no. You can look at my DNA. You can tell me what my IQ score will be, Posthuma says. They probably dont know its much better if you just take the IQ test. Much faster.

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Scientists are finding more genes linked to IQ. This doesn't mean we can predict intelligence. - Vox

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We Need Genetics and Anthropology to Solve the Mysteries of Human Origins – Smithsonian

Posted: at 4:51 pm

According to the textbooks, all humans living today descended from a population that lived in east Africa around 200,000 years ago. This is based on reliable evidence, including genetic analyses of people from around the globe and fossil finds from Ethiopia of human-like skeletal remains from 195,000165,000 years ago.

Now a large scientific team that I was part of has discovered new fossil bones and stone tools that challenge this view. The new studies,published in Nature, push back the origins of our species by 100,000 years and suggest that early humans likely spanned across most of the African continent at the time.

Across the globe and throughout history, humans have been interested in understanding their originsboth biological and cultural. Archaeological excavations and the artefacts they recover shed light on complex behaviourssuch as tool making, symbolically burying the dead or making art. When it comes to understanding our biological origins, there are two primary sources of evidence: fossil bones and teeth. More recently, ancient genetic material such as DNA is also offering important insights.

The findings come from the Moroccan site ofJebel Irhoud, which has been well known since the 1960s for its human fossils and sophisticated stone tools. However, the interpretation of the Irhoud fossils has long been complicated by persistent uncertainties surrounding their geological age. In 2004, evolutionary anthropologistsJean-Jacques Hublin andAbdelouahed Ben-Ncerbegan a new excavation project there. They recovered stone tools and newHomo sapiensfossils from at least five individualsprimarily pieces of skull, jaw, teeth and some limb bones.

To provide a precise date for these finds, geochronologists on the team used athermoluminescence dating methodon the stone tools found at the site. When ancient tools are buried, radiation begins to accumulate from the surrounding sediments. Whey they are heated, this radiation is removed. We can therefore measure accumulated radiation to determine how long ago the tools were buried. This analysis indicated that the tools were about 315,000 years old, give or take 34,000 years.

Researchers also appliedelectron spin resonance dating, which is a similar technique but in this case the measurements are made on teeth. Using data on the radiation dose, the age of one tooth in one of the human jaws was estimated to be 286,000 years old, with a margin of error of 32,000 years. Taken together, these methods indicate thatHomo Sapiensmodern humanslived in the far northwestern corner of the African continent much earlier than previously known.

But how can one be sure that these fossils belonged to a member of our species rather than some older ancestor? To address this question, the anatomists on the team used high-resolutioncomputed tomography(CAT scans) to produce detailed digital copies of the precious and fragile fossils.

They then used virtual techniques to reconstruct the face, brain case and lower jaw of this groupand applied sophisticated measurement techniques to determine that these fossils possessed modern human-like facial morphology. In this way, they could be distinguished from all other fossil human species known to be in Africa at the time.

The high-resolution scans were also used to analyse hidden structures within the tooth crowns, as well as the size and shape of the tooth roots hidden within the jaws. These analyses, which were the focus of my contribution, revealed a number of dental characteristics that are similar to other early fossil modern humans.

And although more primitive than the teeth of modern humans today, they are indeed clearly different from, for example,Homo heidelbergensisandHomo neanderthalensis. The discovery and scientific analyses confirm the importance of Jebel Irhoud as the oldest site documenting an early stage of the origin of our species.

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As a palaeoanthropologist who focuses on the study of fossil bones and teeth, I am often asked why we dont simply address thesequestions of human origins using genetic analyses. There are two main reasons for this. Although incredibly exciting advances have been made in the recovery and analysis of genetic material from fossils that are several hundreds of thousands of years old, it seems that this is only likely to be possible under particular (and unfortunately rare) conditions of burial and fossilisation, such as a low and stable temperature.

That means there are fossils we may never be able to get genetic data from and we must rely on analyses of their morphology, as we do for other very interesting questions related to the earliest periods of human evolutionary history.

Also, understanding the genetic basis of our anatomy only tells us a small part of what it means to be human. Understanding, for example, how behaviour during our lives can alter the external and internal structure of hand bones can help reveal how we used our hands to make tools. Similarly, measuring the chemical composition and the cellular structure of our teeth can tell us what we were eating and our rate of development during childhood. It is these types of factors that help us really understand in what ways you and I are both similar and different to the first members of our species.

And of course, we should not forget that it is the archaeological record that is identifying when we started to make art, adorn our bodies with jewellery, make sophisticated tools and access a diverse range of plant and animal resources. There have been some intriguing suggestions that human species even older thanHomo sapiensmay have displayed some of these amazing behaviours.

More such research will reveal how unique we actually are in the evolutionary history of our lineage. So lets encourage a new generation of young scientists to go in search of new fossils and archaeological discoveries that will finally help us crack the puzzle of human evolution once and for all.

Matthew Skinner, Senior Lecturer in Evolutionary Anthropology, University of Kent

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