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Daily Archives: June 6, 2017
Violence, poverty and politics inextricably linked – Miami Herald
Posted: June 6, 2017 at 6:31 am
Miami Herald | Violence, poverty and politics inextricably linked Miami Herald Gun violence has become a silent epidemic among select Miami-Dade communities, leading to hundreds of intentional injuries every year. We call it silent because most of the burden is borne by just a handful of communities ones that have been ... |
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BBC commissions documentary about commercial space travel fronted by Brian Cox – Radio Times
Posted: at 6:31 am
The BBC is making a documentary about commercial space travel featuring Richard Bransons Virgin Galactic space programme and co-produced by his son Sam's company.
Quest for Space is the working title of the new documentary, which is fronted by Brian Cox and co-produced by Sundog Pictures, the production company run by Sam Branson. Sam Branson, who is chairman of Sundog, is also a friend of Cox.
The BBC has denied suggestions that the commission represents a conflict of interest and insisted that the programme will focus on space exploration and space mining generally and would not be a plug for Bransons company.
A spokeswoman said that it also promised to profile the work of other bodies including NASA and Deep Space Industries and Blue Origin the aerospace manufacturer and spaceflight service founded by Amazon tycoon Jeff Bezos.
Richard Branson is understood to have been filmed by the producers and is expected to feature in the programme, which will air either at the end of this year or early next year. Bezos will also feature.
The commission is also said by sources to be a big deal for Sundog Pictures, which has been suspended by the BBC for any commissions following its documentary Reggie Yates: Hidden Australia which was on BBC3 at the beginning of this year.
The Corporation is completing an investigation into an alleged breach of editorial standards in a section of the programme, where an Aboriginal wake was allegedly filmed as if it were a party scene. Sundog has been suspended from future commissions until the matter is formally resolved.
The commercial space programme show was commissioned before the suspension which is why it has been allowed to go ahead. But RadioTimes.com understands that co-producers Voltage TV Productions have been given editorial responsibility for delivery of the programme because of the suspension.
RadioTimes.com also understands that the BBC is also keeping an eye on this commission generally in order to ensure it is journalistically rigorous.
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What Happens When Cyborg Tech Goes Beyond Medicine? – Singularity Hub
Posted: at 6:30 am
The age of the cyborg may be closer than we think. Rapidly improving medical robotics, wearables, and implants means many humans are already part machine, and this trend is only likely to continue.
It is most noticeable in the field of medical prosthetics where high-performance titanium and carbon fiber replacements for limbs have become commonplace. The use of blades by Paralympians has even raised questions over whether they actually offer an advantage over biological limbs.
For decades, myoelectric prostheticspowered artificial limbs that read electrical signals from the muscles to allow the user to control the devicehave provided patients with mechanical replacements for lost hands.
Now, advances in robotics are resulting in prosthetic hands that are getting close to matching the originals in terms of dexterity. The Michelangelo prosthetic hand is fully articulated and precise enough to carry out tasks like cooking and ironing.
Researchers have even demonstrated robotic hands that have a sense of touch and can be controlled using the mind. And just last month another group showed that fitting a standard myoelectric arm with a camera and a computer vision system allowed it to see and grab objects without the user having to move a muscle.
Medical exoskeletons are already commercially availablemost notably, ReWalk and Ekso Bionics devices designed to help those with spinal cord injuries stand and walk. Elsewhere, this technology is being used to rehabilitate people after strokes or other traumatic injuries by guiding their limbs through their full range of motion.
At present, these technologies are aimed solely at those who have been injured or incapacitated, but an editorial in Science Robotics last week warned that may not always be the case.
There needs to be a debate on the future evolution of technologies as the pace of robotics and AI is accelerating, the authors wrote.
It seems certain that future assistive technologies will not only compensate for human disability but also drive human capacities beyond our innate physiological levels. The associated transformative influence will bring on broad social, political, and economic issues.
This can already be seen with the development of military exoskeletons designed to boost soldiers endurance. More bizarrely, Japanese researchers have recently floated the idea of adding to our limbs rather than replacing them. The MetaLimbs project gives users two extra robotic arms that can be controlled using sensors on their legs and feet.
Last weeks issue of Science Robotics actually included a study demonstrating that a soft robotic exosuit was actually more effective at lightening the load on a runner when it didnt follow a humans natural running pattern and instead used computer simulations to decide what forces to apply.
This suggests there is considerable room for machines to not only augment the power of our muscles but even optimize the biomechanics of our movement. And as the authors of the editorial note, biomechanics is only one strand of research where scientists are trying to replicate and ultimately improve our abilities.
Devices like cochlear implants have been used to restore hearing in the deaf for decades and there are a number of experimental efforts to create bionic eyes to help the blind see again. Efforts to augment our intelligence with neural implants have been widely reported on in recent months.
Admittedly, there is still a long way to go before people start demanding to amputate their arm so they can get a shiny, new robotic one. And its likely the companies driving for consumer-grade neural interfaces are overestimating how many people will voluntarily undergo brain surgery.
But weve already taken the first steps towards merging our biological selves with machines.
You can argue smartphones are already essentially a prosthetic designed to boost communication and memory. And more overtly cyborg-like augmentations are likely to appear in many of our lifetimes.
What then does that mean for humankind? Natural evolution has long relied on mutation conferring minute but significant advantages to individuals that gradually spread throughout populations. If new prosthetic technologies start to confer these advantages overnight the effects could be very patchy.
The worry is that the latest augmentations are only available to the few who can afford them and in just a few generations you could end up with an elite who not only dwarf the rest of humanity financially but also physically and cognitively.
At the same time, these technologies hold huge promise to restore a decent standard of living to the countless people incapacitated by injury or disease. And if applied equitably, devices aimed at augmenting our abilities could better equip us to face the many challenges society faces.
But as the authors of the editorial note, the conversation on how best to guide us through this next stage of our evolution needs to start now. Because these devices have so far been focused on restoring functions that have been lost, we have largely missed the fact that they are now reaching the point where they can improve those functions or even enable new ones.
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Towards an evidence-based Ascension Island Ocean Sanctuary – National Geographic
Posted: at 6:28 am
Written byDr. Judith Brown, Director of Conservation and Fisheries, Ascension Island government
The U.K. government has taken a proactive approach to marine conservation, committing to marine protection around both its own shores and those of its overseas territories in what is known as its Blue Belt commitment. Whilst an honorable statement, now comes the hard work in determining what form that protection should take and how best to deliver marine reserves that really achieve notable conservation benefits to important marine biodiversity. On Ascension Island, a small but dedicated team of marine scientists has been working hard to gather the baseline data on inshore fisheries and biodiversity over the last few years, but their work is spreading to include all of the 200 nautical mile maritime zone the waters that the Ascension Island government is responsible for managing. But gathering data in this larger and less accessible area is much harder and comes at great costs, with the need for a wider team of experts. Fortunately funding has been made available, not least by the U.K. government, to allow these scientific knowledge gaps to be addressed, alongside financing patrolling the waters in search of illegal vessels. Two external grants awarded by the EU Best Initiative and the U.K. governments Darwin Initiative, combined with this ground-breaking National Geographic project, have enabled a dedicated trip to study the practically unknown seamounts that lie within Ascensions waters. These areas were provisionally selected to fall within the zone closed to commercial fishing but they are in desperate need of research to justify if they really are the biological hotspots that we presume and therefore should be included in the final Ascension Island Ocean Sanctuary.
This current National Geographic Pristine Seas expedition has come at a critical time bringing together a core team of scientific experts from a diverse range of disciplines from those who study the bottom of the food chain, the plankton, to the unique benthic communities, to the top level predators, the sharks. This biological research combined with the oceanographic data and the seabed mapping information allows the team to study the entire ecosystem an opportunity very rarely brought together in one expedition. This research is addressing the key priorities in the Ascension Island governments scientific roadmap a detailed plan of information needed to allow management decisions to be made based on scientific evidence. Whilst the data still needs processing we can see that the trip has been an enormous success and already we have witnessed what special habitats the Ascension seamounts are. New records (and very likely) new marine species have been discovered here and bioacoustic data have identified high levels of marine species abundance over the seamounts. Sharks are a species of particular interest due to their susceptibility as by-catch in commercial longline fisheries and here we have gathered unique footage of a not just a diverse range of shark species but evidence of high abundance of silky sharks. When in larger numbers sharks are often less cautious to approaching baited hooks, meaning that at these areas when the sharks are in greater abundance, they are likely to be more susceptible to being caught and a single longline could have a potentially devastating impact on the population found around the seamount. Bigeye and yellowfin tuna have also been seen and tagged during this project to investigate how long they stay around these undersea features and understand the importance of the seamounts to these species. All of this data, when reviewed and processed, will allow us to understand the seamount ecosystems and their wider importance within Ascension waters. However, already we can see they are sufficiently unique and rich in life to make them key candidates to fall within the Ascension Island Marine Protected Area.
Personally this voyage has been a fantastic opportunity to get the chance to work with such enthusiastic and knowledgeable scientists alongside the hardworking and helpful crew of the two vessels is such a positive experience. The logistics to make such an expedition happen goes on unnoticed behind the scenes but was by no means an insignificant feat. The Ascension Island Government Conservation team extends a huge thank you to the National Geographic for making this trip possible and the scientists from the British Antarctic Survey, University of Windsor, University of Western Australia and University of Exeter, not to mention the amazing assistance from the captains and crew of the RRS James Clark Ross and Extractor.
The Pristine Seas team is currently conducting an expedition to the remote island ofAscension, in partnership withtheAscensionIsland Conservation Department, the British Antarctic Survey, the Royal Society for the Protection of Birds, and The Blue Marine Foundation.
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Oregon Ducks’ Deajah Stevens makes a fast ascension in American sprinting ranks – The Register-Guard
Posted: at 6:28 am
Nowhere is Deajah Stevens sudden rise to stardom more apparent than in the increased popularity of her Instagram account.
Last year at this time she had 700 followers. Today she has more than 34,000.
Fame, it seems, has caught up to the Oregon junior.
On the track, however, only a few of her competitors have had the same luck.
After quietly arriving at Oregon 18 months ago and slogging through the early months of her transition to big-time collegiate track, Stevens went from an intriguing prospect at the start of the 2016 outdoor season to a world-class sprinter by summers end.
And that was just the beginning.
Its been a pretty amazing ascent to this point, Oregon associate head coach Curtis Taylor said.
After not winning an individual conference or national title last season, Stevens surprised many including herself with a second-place finish in the womens 200 meters at the U.S. Olympic Track & Field Trials in July, nearly catching Tori Bowie at the line for the title. She then made the Olympic final and finished seventh at the Summer Games in Rio de Janeiro.
Stevens carried that momentum into this season, and the results have been impressive.
She won Pac-12 titles in the 100 and 200 last month and goes into the NCAA Outdoor Track & Field Championship meet this week at Hayward Field as the form-chart favorite in both races.
Stevens owns the fourth-fastest times in the world this season at each distance, having run 11 seconds in the 100 this season and 22.09 in the 200. Both times are personal bests, and her 200 time is also an Oregon school record.
Im a way stronger version of myself than I was last year at this time, Stevens said.
And much more popular too.
Born to run
Memorial Field in Mount Vernon, N.Y., is undergoing a rebirth after years of neglect forced its closure.
The crumbling brick stadium once hosted concerts by James Brown and the Jackson 5, as well as several decades worth of high school and semi-pro sporting events for teams throughout Westchester County.
Its also where Stevens learned to run as a youngster growing up in the suburb just north of the Bronx.
To hide the blight of the decaying stadium as it awaits renovation, the city recently built a wall that doubles as a mural dedicated to Mount Vernon Legends. First on the list of honorees was Stevens, who is pictured running in her Olympic uniform with an American flag waving behind her.
Its so nice, Stevens gushed. When my friends drive by it back home they send me pictures of it. Its really funny.
Mount Vernon Mayor Richard Thomas dedicated the mural in January by declaring Stevens, a girl who knew she could run, but did not know how far she could go until she set foot on the track here at Memorial Field. When she discovered her potential she ran all the way from Mount Vernon to Rio.
It wasnt the first time her hometown had honored Stevens.
In September, just a few weeks after her return from Rio, Stevens was treated to a parade through the streets of Mount Vernon, riding in a car with her mom, sister and the mayor.
If Stevens didnt comprehend before how popular she had become since making the Olympic team, she quickly learned that weekend.
Ive gotten so much love from people on social media and from people here in Oregon, but when I got home, it was really shocking to me how much people were supportive and happy for me, Stevens said. Just meeting adults and kids and people my own age who were like, Oh my God, its you! Its still uncomfortable to me, but Im getting better.
Mount Vernon is also where Stevens spent her first year out of high school.
Denied entry into South Carolina her first school of choice after it was discovered she was one credit short, Stevens sat out a year before enrolling at College of the Sequoias in Visalia, Calif.
She went on to become the California junior college champion in the 200 and 400 in 2015. One year later, she was at Oregon, joining a womens sprint team that included 2015 World Outdoor Championships qualifier Jasmine Todd, future 2016 Olympian and two-time NCAA champion Ariana Washington, and Hannah Cunliffe, who would sweep the Pac-12 100 and 200 later that season.
We knew she was talented, the extent of which I dont think we really knew until we started doing speed testing on her, Taylor said. We found out she has very high levels of speed and power, and if we did it right we could kind of convert all those qualities into a really good sprinter.
Flashes of brilliance
Stevens showed flashes toward the end of the collegiate season last year, finishing second in the 200 and third in the 100 at the Pac-12 Championship meet in Seattle. She was second in the 200 at the NCAA meet as well, behind Washington.
Then came the Olympic Trials.
Stevens entered the final as a longshot in a race that also included Bowie, Allyson Felix and Jenna Prandini.
Theyre peers to me now, but its funny, when I went into the Trials I was so nervous and I felt so young, Stevens said. It was just super crazy to me. Allyson Felix to this day is someone who is so inspiring to me but now shes also a competitor to me, and thats crazy. Thats mind blowing.
It flipped when I made the finals. It dawned on me that I have to stop looking at it like, I guess, starstruck. I had to snap out of it quick.
Bowie led the whole race but it was Stevens who was hot on her trail after coming off the curve. She ran the last 10 meters with a look of disbelief on her face as Prandini was forced to edge out Felix in a photo-finish for third.
While Stevens has said she stunned herself by making the Olympic team the original goal had been Tokyo 2020 her coach could see it coming.
Surprised probably isnt the word, Taylor said. A lot of these kids out here have the ability, its just a matter of if theyre going to put it together or not. So whenever they do really well, youre not surprised because you know they have the capability in them. Its just exciting to see them start to realize what their capabilities are.
Sustaining success is a different challenge, and one Stevens took seriously coming into the 2017 season. Now its time for the payoff.
The NCAA meet wont come without its challenges. LSU junior Aleia Hobbs is the NCAA leader in the 100 at 10.85 and UNLV junior Destiny Smith-Barnett has recorded a wind-aided 10.97. Washington, the defending national champ, is also among the collegiate leaders at 11.06.
In the 200, Stevens is the NCAA leader and also a contender to qualify for the 2017 World Outdoor Championships in London during the U.S. Track & Field Championships in Sacramento later this month.
Im not going to worry about USAs while Im at nationals because those are just two different meets, Stevens said. Im trying to get through nationals healthy and Im trying to train up until USAs.
Theres also another decision looming for Stevens, who will have every chance to turn pro and forgo her senior season at Oregon.
Im going to finish and keep my mind clear through nationals, she said. I need to stay in this space for now and Im trying not to think about it. I really have to talk to Curtis after nationals and see what my best options are. Im not completely opposed to coming back to school, and Im not completely opposed to going pro. I just dont know.
Whatever decision Stevens makes, history suggests more fame will follow.
Follow Chris on Twitter @chansen_RG .
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Launch of Indias biggest rocket is a defining moment in space exploration – DailyO
Posted: at 6:27 am
Indian Space Research Organisation (ISRO) successfully launched its 90th spacecraft mission on June 5, 2017, called GSLV MkIII-D1/GSAT 19. This is one of most important missions launched by ISRO ever, because it successfully lifted a payload mass of 3,136kg, the largest weight ever put by ISRO in outer space.
For the last few years, the Indian space programme is getting recognised as one of the most successful space programmes globally in recent times. However, Indian space capabilities for all these years were suffering from lack of a heavy satellite launch vehicle.
Now, with the success of GSLV Mark III, in the coming few years ISRO should be able to fully operationalise this new launch vehicle for heavy satellites.
Normally, communication and meteorological satellites belong to the category of heavy satellites. Such satellites are 4 to 6 tonne in weight and operate from geostationary orbit (36,000km above the earths surface).
Since, 1983 India has been launching communications satellites mainly under the programme famously known as Indian National Satellite (INSAT) system. Some of these satellites were multipurpose satellites too (they had meteorological payloads).
Today, India has nine operational communication satellites. Together, these satellites have more than 200 transponders in the C, Extended C and Ku-bands. These transponders are primarily used for television broadcasting and for providing various telecommunications services.
GSAT 19 is also a commutations satellite weighting 3,136kg, and is configured around ISROs standard I-3K bus. This satellite carries Ka/Ku-band high throughput communication transponders. In addition, it carries a geostationary radiation spectrometer (GRASP) payload for monitoring and studying the nature of charged particles and the influence of space radiation on satellites and their electronic components.
The success of GSLV III mission is significant for ISRO on various counts. First, it reduces/removes their dependence on outside agencies like the French company Ariane Space for launching of heavy satellites (four to six-tonne category) on commercial basis.
This would allow significant monitory savings and ISRO could use the same money for their various other programmes. Second, India took the help of Ariane Space during September 2013 for the launch of its first strategic satellite called GSAT-7 (being used by the Indian Navy), a multi-band military communications satellite, because GSLV Mark III was not ready by that time. Hence, ISRO was forced to look towards a foreign agency for launching a strategic payload.
India undertook missions to the moon and Mars more as technology demonstrator missions.
Now, in the near future, ISRO would be able to launch the proposed satellites for the Indian Army and air force by using an indigenously developed launch vehicle. In short, the presence of a heavy satellite launch vehicle would also boost Indias strategic space programme.
Third, India undertook missions to the moon and Mars more as technology demonstrator missions. These missions had limited scientific aims owing to ISRO limitations to carry more weight and the missions were undertaken by PSLV (Polar Satellite Launch Vehicle).
Naturally, owing to the capability of this rocket, only a limited number of payloads was carried onboard the moon and Mars missions to study these planets. But now, with a stronger rocket (GSLV), ISRO can develop major scientific goals for future missions to these planets.
Fourth, ISRO has already established itself as a reliable and cost-effective agency capable of launching satellites in the low earth orbit, weighing less than two tonne.
Now, in the coming years, with the maturing of the GSLV system, ISRO could be able to make inroads in the global commercial heavy satellite launch market.
Today, a good number of countries in the world can develop satellites and sensors. Many such efforts are collaborative efforts and are among two or more countries. However, mastering the art of rocket science remains a difficult proposal even today.
Hardly 11 countries in the world have developed such capabilities and they are able to launch satellites by using their indigenously built rocket systems. Among these countries only Russia, US (also private agency called Space X), China, Japan and the European Union can launch heavy satellites in the geostationary orbit.
Now, with the successful launch of GSAT 19 by using GSLV Mark III-D1, India has joined this club. In compression, with the earlier rockets developed by India (SLV, ASLV and PSLV), the GSLV is bigger in size and purpose (for launching heavy satellites) and hence fondly gets referred to as Fat Boy.
However, knowing the importance of GSLV for the future of Indias space programme and the type of role it is expected to play in the near future, this Fat Boy needs to be rechristened as a Suitable Boy!
Also read:ISRO launching its biggest rocket ever, GSLV-Mk III, is a bold move by India
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Stop Policing Psychedelic Science – Motherboard
Posted: at 6:25 am
This story is part of When the Drugs Hit, a Motherboard journey into the science, politics, and culture of today's psychedelic renaissance. Follow along here.
In 1988, Rick Strassman set out to do what seemed to be impossible: convince the US government to let him give people illegal drugs.
But not just any illegal substances. Strassman, a psychiatrist at the University of New Mexico, wanted to dose subjects with one of the most potent psychedelics ever discovered: dimethyltryptamine (DMT), a neurotransmitter and tryptamine molecule that naturally occurs in the plant and animal kingdoms, including in humans. Strassman hoped to investigate the physiological and psychological effects of DMT, the so-called "spirit molecule," but knew that getting approval to do this research was a long shot.
Like pretty much every other psychedelic drug known at the time, DMT had been classified as a Schedule I substance under the 1970 Comprehensive Drug Abuse Prevention and Control Act. This meant that there was no recognized medical use for the substances and effectively placed a moratorium on all psychedelic research using human subjects. Studying and administering substances gets progressively easier as you move from Schedule I to Schedule V. Substances in Schedule I, including heroin, are the only ones, in fact, that require a special license to study.
But these obstacles didn't deter Strassman. After 19 months of arduous paperwork and a seemingly interminable argument with the Drug Enforcement Administration, in early 1990 he dosed his first participant with DMT. It was the first psychedelic study using humans in two decades.
"I figured as long as the DEA weren't saying no, it remained a potential yes," Strassman told me recently. "I never really gave up."
"'I don't care if you guys are smoking mushrooms back there, just keep out of the paper, get your grants and keep your cards close to your chest.'"
In the nearly three decades since Strassman's groundbreaking DMT study, little has changed for researchers hoping to study the effects of psychedelic compounds on humans. Although psychedelic research is experiencing a sort of renaissance, getting approval to study these substances is more difficult than ever.
At the same time, recent work done on psychedelics has shown potential in treating everything from post-traumatic stress in veterans to promoting creative problem solving and treating addictions.
If the federal decision to classify these substances as having no medical value was premature, then understanding the benefits (and dangers) of psychedelics in a rigorous and empirical way has been hindered by bureaucracy and authorities policing research laboratories. I reached out to Strassman and contemporary clinicians to learn more about their experiences and the difficulties faced by psychedelic researchers today. Just how hard was itis itto get the greenlight from Uncle Sam?
That's getting ahead. For most psychedelic scientists, problems begin at the local level.
*
To do science on humans with illegal substances, researches are required to submit a proposal to an institutional review board, which is supposed to ensure the experiment is both ethical and safe. Given the taboo surrounding psychedelics and universities' tendency to avoid controversy, even the safest and most well-designed studies may flounder on the shores of a dean's idea of what constitutes respectable science.
Fortunately for Strassman, he said the University of New Mexico was somewhat "off the beaten path," and that his psychedelic study was much less likely to draw significant attention than if it had been conducted at an Ivy League institution. Moreover, Strassman said neither his department chair nor the university president really cared what he was up to in his lab, so long as he "kept his nose clean."
Read More: America's Trippiest Chemist Says Making Psychedelics 'Was Fun'
"I spoke with the chairman of the research unit and he said, 'I don't care if you guys are smoking mushrooms back there, just keep out of the paper, get your grants and keep your cards close to your chest,'" Strassman remembered.
After gaining approval from the university, Strassman then had to make his pitch at the federal level, specifically the DEA and the Food and Drug Administration. The DEA was responsible for doling out Schedule I licenses, which authorized licensees to possess these illicit substances. The FDA, for its part, would give Strassman approval for what's known as an IND, or Investigative New Drug trial, which would allow him to administer the Schedule I substance to human subjects.
There was only one problem: The DEA wanted to see the FDA's IND license before granting its Schedule I license, and the FDA, in turn, wanted to see that Strassman was approved to use the Schedule I substance before granting the IND. It was a catch-22.
But as Strassman began to facilitate unprecedented degrees of contact between these two federal agencies, he realized he had a far more pressing problem to deal with: how to procure the DMT for the trials in the first place. In order to get his Schedule I license from the DEA, he would have to show that the DMT was pure, and that he would only have access to a limited and necessary amount of the substance.
Eventually Strassman linked up with Dave Nichols, a chemist at Purdue University with DEA approval to synthesize 15 Schedule I psychedelics and 20 years of experience doing just that. After finding a hookup for the DMT, Strassman returned to the DEA and started filling out the paperwork.
Several months later, Strassman had his Schedule I license and IND. It had been over a year-and-a-half of starts, stops, and red tape. But he was finally set to begin his research.
DMT crystals. Photo: Psychonaught/Wikimedia Commons
When Strassman was setting out, he had to rely on trial and error in his dealings with the feds, who were less than receptive to the idea of allowing Schedule I substances to be opened for research purposes.
The first paper Strassman wrote after receiving approval for his study was about how he managed to even make this happena kind of blueprint for getting approval to do psychedelic science. Although he was criticized for revealing hard-won, "sensitive" information about government legal processes, his blueprint was effective. According to Strassman, it helped guide researchers at the University of Arizona, University of Miami, and Johns Hopkins University set up their own studies on psilocybin (the psychedelic compound in "magic mushrooms") and ibogaine in the late 90s and early 2000s.
But overregulation continues to crush psychedelic science. Even with Strassman's blueprint and a number of precedents in place, getting approval to study psychedelics is still a steep challenge.
The Multidisciplinary Association for Psychedelic Studies (MAPS), for example, has been pushing the limits of psychedelic research for decades now, yet its trials on MDMA and PTSD keep stalling out in a maze of bureaucratic and legal obstacles.
MAPS hopes to begin the third and final FDA study this year, and to see MDMA be a FDA-approved prescription medicine by 2021. But the phase 3 study is also the most difficult since it requires special parameters for the trials, which include large cohorts of study participants as well as using chemicals produced under a Good Manufacturing Practices (GMP) regime. GMPs are mostly quality control measures, but since the MDMA used in the first two phases was already 99 percent pure, this means that GMP is mostly a regulatory requirement that places copious paperwork and protocols on the researchers for the duration of the trial phase.
"Rescheduling would release a lot of these barriers that exist only for Schedule I substances."
This also means that MAPS will have to find a new source for its MDMA since the drug must be manufactured under GMP conditions. Even though pharma companies like Sigma-Aldrich have websites set up where you can order small quantities of every imaginable psychedelic, these won't meet the phase 3 GMP requirements. Natalie Ginsberg, a MAPS policy and advocacy manager, said so far just finding a manufacturer for the stuff has been hard enough.
Then there's the money problem. Historically, most psychedelic studies have been funded by the National Institute of Drug Addiction (NIDA). Although NIDA's pockets run deep, the agency is particular about the kind of drug research it will fundthat is to say, only research that investigates the abuse potential of substances, not their therapeutic potential. As such, organizations like MAPS have had to seek private funding for studies, which, all told, will cost millions of dollars. The GMP MDMA alone will cost nearly $500,000 for 1.5 kilos.
In this respect, Strassman realizes he was lucky. For his DMT trials, he had secured two competitive grants to support him during the year-and-a-half it took to get approval just to begin his research. Without this grant money, Strassman said it's unlikely he would've had the time or energy to pursue this research project.
Ultimately, he and Ginsberg see the difficulties faced by researchers as a consequence of the War on Drugs and its scheduling regime.
"All these extra burdens put on researchers like waiting for a Schedule I license, finding the right location, finding a manufacturer of the drug, add months or years to the process," said Ginsberg. "People who do psychedelic research aren't just any old researchersthey have to be committed and willing to fight through the regulations and have patience to wait for months on end for approval. Rescheduling would release a lot of these barriers that exist only for Schedule I substances."
Read More: How to Legally Buy a Kilo of Pure MDMA
Strassman likewise said he'd like to see psychedelic substances rescheduled, though he realizes researchers are caught between a rock and a hard place. To keep psychedelics as Schedule I substances makes researching them prohibitively hard, but to call for reclassifying them as Schedule II substances is unlikely to succeed either.
Schedule II substances, including stimulants like cocaine and Adderall, can be prescribed by everyone from dentists to veterinarians. As Strassman sees it, trying to argue that something like LSD should be as easily accessible as Adderall is a non-starter. Instead, he advocates for a new, intermediate schedule between I and II, that would make the substances easier to study, but not absurdly easy for a layperson to obtain.
"I think that category of clinical reality ought to be combined with a legal category of the scheduling," Strassman said. "People wouldn't be able to possess and give these drugs without special training and without certification and supervision, but if you keep them kind of behind the lock and key of Schedule I, you're also not going to be able to give them to people who might benefit."
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Best Nootropics Smart Pills – Serie A Weekly
Posted: at 6:25 am
Without a doubt, youve stumbled across the term nootropics somewhere on the internet and wondered what they were. Theyve become one of the hottest trends, driven in popularity by celebrity endorsements that tout claims that theyll enhance your memory and focus, and increase your intelligence. But what exactly are nootropics, and are they beneficial for your cognitive function?
The word itself was coined by a Romanian chemist and psychologist, Dr. Corneliu Giurgea, who was the first to synthesize a nootropic more than 50 years ago. According to Dr. Giurgea, his piracetam was able to enhance learning, disassociate memories to conditions that led to the development of undesirable learned behaviors, protect the brain from chemical injury, and was very low toxicity, thereby producing very limited side effects.
Today, there are a wide variety of nootropics, often grouped in with what is frequently referred to as smart drugs. In actuality, they are a class of supplements, made from both naturally occurring chemicals and synthetic, that are designed to enhance the cognitive functioning of the brain. Theyre often used to help individuals focus and increase attention span, especially as they age, though many college students have begun to use them as study aids.
Unlike real smart drugs, nootropics do not produce the adverse side effects when used long-term. They are safe, posing little risk of any side effects, and are neuroprotective when used as directed.
All nootropics operate by enhancing communication between neurons in the brain, improving neurotransmitter functioning and promoting brain health. There are even some that believe that nootropics stimulate neuron growth, facilitate the formation of synapses in the brain, enhance neuroplasticity, and improve energy metabolism in the brain.
Essentially, your brain is a network of neurons, which are interconnected through pathways called synapses. There are billions of neurons in your brain, and their purpose is to communicate through neurotransmitters, specific chemicals that facilitate the ability to send signals from one neuron to another. When your neurons operate efficiently, you experience better moods, the capacity to process mental work more quickly, longer attention spans for even the most tedious of tasks, and better memory and concentration.
Supplementation with nootropics improves the synaptic plasticity of your brains neurons to provide all these benefits. Over an extended period of time, consistent supplementation with nootropics can even slow down the signs of aging, such as brain fog and memory loss. Theyre even able to counteract the development of brain disorders, like Alzheimers Disease.
In addition to improving the synaptic plasticity of your neurons, Nootropics improve the health of your brain, and thereby its functioning, by increasing the amount of blood flow to it. This increased blood flow carries with it more nutrients, glucose, and oxygen, all primary fuel sources that your brain uses for energy when it focuses.
Interestingly, the brain only makes up 2% of your total body weight, but it is responsible for 20% of your energy consumption. This is because the brain requires a lot of energy to function properly and to be able to focus on the external environment. It even takes a significant amount of energy just to sustain consciousness.
The anecdotal evidence supports claims that nootropics can provide all of these benefits, but there is still the need for more studies. If you choose to try them out for yourself, look for signs that they are working, such as less brain fog and more mental clarity. They may just be what your brain needs, and could even be life-changing.
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How Do Various Nootropics Work? – Serie A Weekly
Posted: at 6:25 am
If you, or more likely your child, have been diagnosed with ADHD, the doctor may have suggested a nootropic. Nootropics are cognitive enhancement drugs. Essentially, theyre drugs that boost memory, focus, and the other mental abilities people need to interact with day to day life. There are a lot of myths about these drugs, so hopefully, youre here to learn.
What Things Are Nootropics?
By and large, nootropics are stimulants. There are things called racetams, but these have questionable effects on the body. Most doctors will stay away from racetams, instead going with something stimulant based.
That said, nootropics dont have to be pharmaceutical grade stimulants. Some stimulants such as caffeine can often work as nootropics, and be capable enough on their own.
How Do Various Nootropics Work?
Caffeine is an excellent example of a mild nootropic. Everyone knows how that works. It helps kick your brain into working, helping you wake up and pay attention. This is exactly what you want in a nootropic!
The next step up is a class of drugs called Eugeroic. These are wakefulness promoters. These work in a similar way to dopamine reuptake inhibitors work. That is, they keep the brain from processing dopamine quite as quickly as it would normally process. This helps keep you awake, and as a side effect improves other cognitive abilities.
The step up from that is Methylphenidate. This is a potent dopamine reuptake inhibitor, keeping the brain from processing the dopamine for a much longer period. This not only helps with cognitive functions but also with mood issues. Doctors have been known to prescribe methylphenidate for depression, though this practice is not commonly used today.
The big guns on the list of nootropics are amphetamines. The most common prescription amphetamine currently is Adderall, though there are other medications. These are not dopamine reuptake inhibitors but instead floods the brain with it. This causes there to be so much more dopamine within the brain that it cant help but process more.
Are Nootropics Dangerous?
The pharmaceutical nootropics can be dangerous, and anyone who says otherwise is lying. Just like too much coffee can cause your heart to race, too much of any stimulant can cause issues. In the case of overdose, people have been known to die of heart attacks.
Also, some people tend to exhibit a style of mania. Because theyre so happy and feeling so high, they start to make poor choices. This is similar to use of the illegal drug cocaine.
And lastly, many studies indicate long-term use in children can stunt a childs growth. Many doctors will suggest waiting until the child is around 12 before prescribing prescription stimulants.
Ultimately, nootropics are a necessary medical substance for many people. While its true they sometimes get abused by those just looking for a good time, individuals with ADHD and other cognitive illnesses need nootropics. It can help them lead a working, fulfilled life. So if your doctor is suggesting one of these drugs, either for you or your child, dont dismiss it out of hand. You might be surprised at what happens!
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Trance (2010) – IMDb
Posted: at 6:24 am
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