Daily Archives: June 1, 2017

100-Year-Old Drug May Be the Key to Treating Autism – Futurism

Posted: June 1, 2017 at 10:07 pm

In BriefA small clinical trial has demonstrated that 100-year-old drugcan relieved symptoms of autism in children. The work has alsogenerated a unifying theory of ASD linking the disorder to alteredmetabolic processes. Old Drug, New Tricks

A small clinical trial fromthe University of California, San Diego, has just yielded some promising results for those living withautism spectrum disorder (ASD). The results indicate that suramin, a 100-year-old drug used to treat African sleeping sickness, can measurably, albeit transiently, improve ASD symptoms in children.

This has led the research team to conclude that ASD in many children may becaused by a treatable metabolic syndrome and that, for some people with ASD, the right treatment can improve symptoms since they are not necessarily permanent.

ASD is just that a spectrum, and many children fall somewhere on that spectrum. According to the World Health Organization, about one in 160 children worldwide have ASD, although the CDC estimates that number to beone in 68.While it is not entirely clear whether the incidence of ASD is increasing, or detection of ASD is changing, or some other mechanism is at work making the numbers grow, there is no doubt that many people are affected.

The UCSD team is now focusing on metabolismthe shared language of the brain, immune system, and gutwhich allows the three linked systems to communicate. In peoplewith ASD, each of these systems works differently, and the communication between them is altered.

The researchers chose to test suramin because it inhibits purinergic signaling, a cell communications process that takes place in metabolism. Within seven days, all five of the children treated with suramin showed a steady improvement of symptoms, with no change at all shown in the placebo group.

These results mark the first time any drug has shown the potential to actually altersymptoms of ASD. Of course this is a small first trail, and the treatment may never be available depending on further research outcomes. Even so, these results are likely to prompt a major shift in the way we think about autism.

If the researchers are right, abnormally persistent cell danger response (CDR) is whats producing the metabolic syndrome causing ASD. Both environment and genes are factors in the CDR, so its possible that genetic causes alone might produce the metabolic syndrome and ASD. However, if a metabolic syndrome is whats behind ASD symptoms, it can be treated, even though the genes cant be.

This research also provides the first real unifying theory for the root cause of ASD. The lack of such a theory has been a huge factor in pharmacologic failures in treating aspects ASD. Treatments werent targeting the aspect of autism that could lower peoples quality of life and were sometimes worse than symptoms.

However, if this unifying theory is right thatCDR and problems in purinergic signaling play an important role in some forms of ASD, then doctors should be able to treat some symptoms of ASD such as difficulties with verbal communication, fear of changes in routine, and social anxiety without suppressing the traits that sometimes make people with ASD exceptional.

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Apple Founder Says Tesla, Not Apple, Will Create The Next Breakthrough Technology – Futurism

Posted: at 10:07 pm

Apples Other Steve

Experts in techand tech enthusiasts alike know that there wasnt just one Steve behind Apple. While Steve Jobs was the popular (and disruptive) face of the company, Steve Wozniak was the genius behind Apples earliest technology most notably, the original Macintosh that was the key to Apples initial successes.

No stranger to innovation himself, Wozniak has made some startling assertions recently, stating that hethinks that the next big thing in tech wont be coming from the company he co-foundedand in whichhe still owns a sizable amount ofstock. In a recent interview with Bloomberg Canada,

Wozniakis betting that Tesla, and its CEO Elon Musk, will be the source of the next, greatinnovation.

I think Tesla is on the best direction right now. Theyve put an awful lot of effort into very risky things, Wozniak said. They started with a carthe Tesla Model Sthat made little sense in engineering terms in how much you have to build for what price and what the market will be.

Its precisely that kind of attitude that won Wozs admiration. Im going to bet on Tesla, he added.

Back in the day, Jobs and Wozniak didnt always see eye to eye, but its not this largely unspoken conflict that made Woz bet on Tesla. More than anything, its the bit of Apple that Woz sees in Tesla now. Look at the companies like Google and Facebook and Apple and Microsoft that changed the worldand Tesla included. They usually came from young people. They didnt spring out of big businesses, he said.

For the most part, its also because Tesla started with a product that Musk liked very much. Again, this is another parallel with how Apple started froma project Woz was building as a hobby. It was really built for Elons own life. What car would he like? And when things come from yourself, knowing what youd like very much and being in control of it .thats when you get the best products, he explained.

Tesla and Musk have gone a long way from that first electric car. For one, Woz admires Musks latest boring project. Apple, on the other hand, seems to be suffering from a lack of innovative spark. This has led some toargue that Apple and Tesla might work better by combining their resources together Apples money and Teslas innovation. However, Musk has alreadycast doubt on the proposal. Alas.

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Futurist Dr. Randell Mills Talks SunCell, Off-Grid Power, And The Future Of Job Creation – HuffPost

Posted: at 10:07 pm

Jobs, Musk...Mills? Every now and then, a revolutionary thinker imagines a future the rest of us cant, or in the case of Randell Mills, imagines technology that defies the laws of quantum mechanics. Initially mocked, Jobs retains a godlike status, even posthumously. And Musk, well, hes proved skeptics wrong for years, and yet his talk of Hyperloop Pods traveling at hundreds of miles per hour under the streets of L.A. seems like fantasy to many.

If there is one thing Ive learned from working for and alongside hundreds of entrepreneurs over the last two decades it is this: pay attention to big thinkers whose ideas presently seem unimaginable, especially when these thinkers are determined to transform the world.

Give me the chance to connect with them personally, and Im all in.

Not without his own skeptics, I recently had the chance to sit down with Mills and hear about his latest invention, the Sun Cell, which promises to bring clean and cheap energy to the world. As we chatted, I found myself imagining the possibilities and the potential. Lifting millions from poverty? Check. Tackling climate change. Check again.

Mills says the SunCell works by generating electricity with hydrogen being converted to dark matter by using water in the air, and the reaction packs 200 times the energy of burning conventional gasoline. Sound too good to be true? Well, Mills is betting SunCell will soon be commercialized, and strategic investors are backing that bet. Brilliant Light Power (which Mills founded in 1991), has raised $120M to date and has recently completed a $20M funding round.

Imagine living in a world where the grid does not exist and where everyone has access to power, no matter who you are or what part of the world you live. That would be something else.

Rebekah Iliff: Do you consider yourself an inventor, an innovator, an entrepreneur, a social entrepreneur, or a futurist?

Randell Mills: All of the above. To do what I do, you not only need to be an inventor and a theorist but also have a firm comprehension of how to make things work in practice. When your goal is nothing less than delivering a power source greater than fire, your only choice is to be multi-faceted. Otherwise, youre just making incremental improvements, not holistic leaps forward. High-energy dark-matter power as a business seems totally impractical. It is barely fathomable, so youve got to tackle theory, innovation, invention, and practical business simultaneously.

RI: You are a trained medical doctor. Why did you choose to focus on energy?

RM: If you look broadly at science and technology, one thing is ultimately connected to another, and energy just naturally called to me. In fact, Ive invented in a number of different areas, including hydrogen energy technology, computational chemical design, magnetic resonance imaging, drug delivery, artificial intelligence and more. But theres really no better opportunity to work on something that could be so profoundly disruptive.

RI: Explain the SunCell for dummies.

RM: Its a massive lightbulb that is on 24/7 and produces cheap and clean energy from the hydrogen atoms of water. Its lit by a reaction between of hydrogen of water molecules to dark matter using the humidity in the air as the water source. Its over 1000 times as powerful as high-octane gasoline, and the power is directly converted to electricity using photovoltaic cells.

RI: What does the world look like when youve commercialized the SunCell?

RM: Everything will be powered by the SunCell. Solar, wind, bio fuels, and nuclear will all be replaced. The grid will be unnecessary. Utilities will be unnecessary. There would be no pollution and limited energy regulation. As the SunCell is fully autonomous, energy delivery becomes impervious to disruption from war, terror, and natural disaster. Importantly, underdeveloped countries will have the same potential lifestyle and productivity as the developed world. Each SunCell could also serve as a self-powered, autonomous node in a mesh network that could replace the Internet.

RI: How would it impact jobs?

RM: Jobs are created by wealth. If you have something that encourages productivity, then there will be jobs. The SunCell encourages productivity by leveling and equally distributing the energy playing field for virtually anyone, anywhere. There is literature about GDP and energy dependency, and its very revealing in terms of how dependent we are on power.

RI: I know a lot of folks at your level would let ego get in the way. How do you stay grounded?

RM: My background is helpful. I didnt come from the Ivy League. Most people in my life were not Harvard or MIT graduates. They werent captains of industry. They were honest and worked hard. I grew up on a farm in Cochranville, Pennsylvania, where life was very challenging and humbling. You earned an appreciation for dangerous equipment at an early age. Ive interacted with all types of people from every stature in life, and Ive always maintained that simple farmers perspective.

RI: What is your PR strategy around this? How do you plan on shifting the public opinion enough to override business as usual?

RM: We have a multi-pronged approach. Were introducing state-of-the-art theory, science, and technology that astonishes experts with quantifiable and verifiable results in multiple scientific and technological fields, and we are building a machine with a story behind it that blows everyone else away. Within a couple months we should be ready to show its commercial potential.

RI: Any parting thoughts youd like to share?

RM: I think the next age is an age where mankind has a manual of the universe and knows exactly how the universe works. We then begin to create previously unimaginable inventions by applying this manual and the newly discovered laws that come along with it. The next big future is the physical age.

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The Futurist: Be open to all comers – Human Resources Online

Posted: at 10:07 pm

Debbie Mannas, group head of human resources, Wallem, believes culturally inclusive hiring practices are essential for the continued success of businesses.

When it comes to talent acquisition, HR practitioners must purposefully ensure culturally inclusive hiring continues into the future or risk losing their place as talent protagonists.

As we have seen, an increasing trend toward nationalism has recently led to some governments throwing out the proverbial baby with the bathwater when it comes to bias and political correctness.

Some anecdotal evidence points to business leaders following suit, swinging from a dont say/do it or we will get sued culture to an anything goes because our nations leader is OK with it culture.

Ironically, history tells us that with an influx of new minds and new ways actually come huge strides in progress, innovation and growth.

HR teams are often the first point of contact for candidates, and the business culture is reflected in their mindset. Their mindset, in return, is based on that of the business leaders. So if the mindset of the leadership, and therefore the HR team, is to hire in their own likeness, the extent of innovation, growth and sustainability will be limited.

Therefore, HR must resist the nationalistic bandwagon and evolve past generalisations. For the sake of business, and indeed, national interests, we must be culturally inclusive, and influence our teams as well as our leadership to embrace collaboration and idea sharing. D&I initiatives must be seen as a talent imperative, not just a CSR box to check.

In a number of Asian countries, I have noticed an insistence on specific language skills in job ads, even if the role requires very little comprehension of that language; rather than worrying about rarer skills such as problem solving, creativity and communication.

Similarly, certain cultures are considered lazy and their CVs discarded just by looking at their names. On the flipside, someone from a native English speaking country may be hired as a teacher, even if their English is appalling.

If branded as biased, HR will lose its place as a talent attractor. Good candidates will instead contact others higher up in the organisation, or worse reach out to a competitor. Ive witnessed talented individuals from diverse backgrounds gravitate towards organisations that display openness and inclusivity, leaving organisations that dont, behind.

To build teams for the future, we must be agnostic towards all else but talent. Until we can look past the stereotypes that ethnicity, gender, age, religion, sexual orientation, etc, conjure up, we will continue to see a push for such identifying data to be left off applications, forcing the issue.

In short, unless you created the world in six days and rested on the seventh, its best not to attempt to create teams in your own image. Your business depends on you being open to all people.

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