Monthly Archives: February 2017

Genetic profiling can guide stem cell transplantation for patients with myelodysplastic syndrome, study finds – Science Daily

Posted: February 11, 2017 at 7:46 am

Genetic profiling can guide stem cell transplantation for patients with myelodysplastic syndrome, study finds
Science Daily
A single blood test and basic information about a patient's medical status can indicate which patients with myelodysplastic syndrome (MDS) are likely to benefit from a stem cell transplant, and the intensity of pre-transplant chemotherapy and/or ...

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Researchers find potential treatments for hemoglobinopathies – Medical Xpress

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February 10, 2017

An article published in Experimental Biology and Medicine (Volume 242, Issue 3, February, 2017) identifies microRNAs (miRNAs) as key factors in some hemoglobinopathies, genetic disorders characterized by alterations in the level or structure of the globin proteins that are responsible for oxygen transport in the blood. The study, led by Dr. Thais Fornari, from the Department of Internal Medicine at the University of Campinas in Brazil demonstrated that differential expression of miRNAs may be responsible for the variations in globin gene expression observed in patients with two hemoglobinopathies: hereditary persistence of fetal hemoglobin deletion type 2 (HPFH-2) and Sicilian-thalassemia.

HPFH-2 and Sicilian-thalassemia are conditions described as large deletions of the human -like globin cluster, with no -globin expression and compensatory increases in -globin expression. MicroRNAs (miRNAs) are small non-coding RNAs that participate in a wide range of biological processes including erythropoiesis. miRNAs silence the expression of other genes by binding to their mRNAs, and blocking protein synthesis and/or initiating mRNA degradation. Transcription factors such as BCL11A and SOX6, which regulate -globin gene expression, are potential targets for several microRNAs based on in silico analysis. Thus, novel miRNA-mediated pathways may explain the differences in the expressions of -globin in Sicilian thalassemia and HPFH-2.

In the current study, Dr. Fornari and colleagues compared the miRNA profiles of erythroid cells derived from individuals heterozygous for HPFH-2 and Sicilian-thalassemia. Forty-nine differentially expressed miRNAs that may participate in -globin gene regulation and red blood cell function were identified. Twelve of these miRNAs potentially targeted the BCL11A gene, and down-regulation of BCL11A gene expression in HPFH-2 was verified by qPCR. This research suggests an important action of miRNAs in the regulation of globin expression in patients. Fornari said that these findings "may partially explain the phenotypic differences between HPFH-2 and Sicilian -thalassemia and the variable increases in -globin gene expression in these conditions. Moreover, these data support erythroid BCL11A as a therapeutic target for sickle cell disease and -thalassemia major patients."

Dr. Steven R. Goodman, editor-in-chief of Experimental Biology and Medicine, said, "Fornari and colleagues provide further evidence for the role of miRNA networks in the regulation of fetal hemoglobin expression, via altered expression of BCL11A and SOX6. These studies are important when considering these transcription factors as potential therapeutic targets".

Explore further: Mechanisms, therapeutic targets of microRNA-associated chemoresistance in epithelial ovarian cancer

Journal reference: Experimental Biology and Medicine

Provided by: Experimental Biology and Medicine

Specific genetic errors that trigger congenital heart disease (CHD) in humans can be reproduced reliably in Drosophila melanogaster - the common fruit fly - an initial step toward personalized therapies for patients in the ...

A newly discovered mutation in the INPP5K gene, which leads to short stature, muscle weakness, intellectual disability, and cataracts, suggests a new type of congenital muscular dystrophy. The research was published in the ...

Kawasaki disease (KD) is the most common acquired heart disease in children. Untreated, roughly one-quarter of children with KD develop coronary artery aneurysmsballoon-like bulges of heart vesselsthat may ultimately ...

Investigators at the Medical University of South Carolina (MUSC) report pre-clinical research showing that a genetic variant encoded in neutrophil cystolic factor 1 (NCF1) is associated with increased risk for autoimmune ...

Geneticists from Trinity College Dublin have used our evolutionary history to shine light on a plethora of neurodevelopmental disorders and diseases. Their findings isolate a relatively short list of genes as candidates for ...

It's been more than 10 years since Japanese researchers Shinya Yamanaka, M.D., Ph.D., and his graduate student Kazutoshi Takahashi, Ph.D., developed the breakthrough technique to return any adult cell to its earliest stage ...

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Whoopi Goldberg, a blackface Ted Danson, and the most politically incorrect comedy routine of all time – Telegraph.co.uk

Posted: at 7:45 am

On Saturday, Whoopi Goldberg will bring her stand-up show, Whoopi Goldberg Stand Up Live! to the UK for the first time. For one night only, the Oscar winner will give the London Palladium a taste of the kind of outrageous, boundary-pushing comedy that has come to define her over a three-decade career. How outrageous? Well, in 1993, she was partially responsiblefor a comedy routine so incendiary and offensive that it threatened to topple a comedy institution, offended Americans of every race, and possibly ended her relationship.

Now 61, Goldberg, who has dabbled in activism and childrens books in recent years, launched her newest venture last year: a company that makes medical marijuana products to help ease period pains. She also continues to rack up credits on film and TV series. However, Goldberg is more often making headlines for her provocative support of controversial figures, such...

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Campus free speech under attack, literally – The Spokesman-Review

Posted: at 7:45 am

The following editorial is from the Orange County Register.

The violence that erupted at UC Berkeley last week during the protest of a planned speech by Breitbart News senior editor Milo Yiannopoulos, known for his conservative and decidedly politically incorrect views, was a sorry display and a blow to free speech.

It is ironic that such a demonstration took place at the birthplace of the Free Speech Movement during the 1960s. The demonstration began peacefully, with up to 1,500 protesters expressing their opposition to the conservative journalist and speaker. But then about 150 black-clad and masked agitators infiltrated the event, shooting fireworks at police, setting fires and smashing windows on campus and in the surrounding downtown area. Several apparent supporters of the event were beaten or pepper sprayed.

The provocateurs are reportedly from a group called Antifa, which claims to be an anti-fascist organization, yet remains oblivious to the fact that it adopts fascist tactics to violently suppress opposing views.

We regret that the threats and unlawful actions of a few have interfered with the exercise of First Amendment rights on a campus that is proud of its history and legacy as home of the Free Speech Movement, the university said in a statement. (W)hile Mr. Yiannopoulos views, tactics and rhetoric are profoundly contrary to our own, we are bound by the Constitution, the law, our values and the campus Principles of Community to enable free expression across the full spectrum of opinion and perspective.

If only others, particularly on left-leaning college campuses, felt the same way. Even before the violent agitators arrived on campus, for example, the peaceful protesters voiced their opposition to free speech, shouting Shut it down outside the building where Yiannopoulos was to speak and cheering when it was announced that the talk had been canceled.

Yiannopoulos remained defiant afterward. One thing we do know for sure: the left is absolutely terrified of free speech and will do literally anything to shut it down, he wrote in a Facebook post.

Such actions by progressive students to stifle nonliberal campus speakers have become a disturbing trend, however, and have only intensified since the election of President Donald Trump. There seems to be a cognitive dissonance among them of equating speech that they deem intolerant with violence, and then using actual physical threats and violence to prevent that speech.

It is a sad commentary on our supposed institutions of higher learning when diversity is idolized in every respect but the most important one the diversity of thought; when tolerance is a virtue except when it comes to the tolerance of contrary viewpoints.

The culture of too many college campuses has shifted from one of a search for knowledge and truth to indoctrination camps for immature, malleable minds and training grounds for social activism.

Published Feb. 11, 2017, midnight in: free speech, UC Berkeley, Violence

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Censorship versus free speech at a very local level – San Francisco … – San Francisco Chronicle

Posted: at 7:44 am

Free expression seems to be top of mind in the Bay Area these days. Ive been thinking about it, too but not in the context of how one should respond to a decadent disrupter whos chosen to threaten vulnerable people as part of his personal brand.

No, Ive been thinking not about Berkeley but about a quieter case in San Jose.

Thats where the Rev. Jeff Moore, a counselor at Independence High School in San Jose and president of the San Jose/Silicon Valley branch of the NAACP, was putting together the annual Black History Month display for the district office of East Side Union High School District.

Moore had seen and liked the work of Mark Harris, 47, a San Francisco painter and mixed-media artist. So he asked Harris to pull together a small exhibit of his work. Harris agreed. He drove down to San Jose and installed the work in the districts display cases on Jan. 30.

On Jan. 31, Harris woke up to a two-line email from Moore, saying that his work had been taken down.

So began a local censorship controversy thats stretched into a third week. Multiple media outlets have covered the story, and the National Coalition Against Censorship has taken an interest.

I should mention that Harris was an acquaintance of mine before any of this happened.

"Immigration Theory," a mixed-media piece by Mark Harris

"Immigration Theory," a mixed-media piece by Mark Harris

But my hunch is that Id probably have the same response even if I didnt know him: oh, no.

Pretty much, Harris said, Ive never had this happen before. Its disappointing because we have to tackle these issues if were going to come together as a country. And what better place to start this conversation than a school district?

Moore said hed hung Black History Month displays at the district for several years in a row, with no problems. Previous displays had been portraits of civil rights leaders, libraries of slave narratives and other pieces from Moores home.

This year, I thought these paintings were educational and gave us a chance to be in a dialogue with what America is talking about, Moore said.

The paintings are definitely political, verging on agit-prop: They juxtapose wholesome, 1950s-era kitsch images of white America with images of slavery, the Confederate flag and anti-police-brutality protests. These are certainly ideas that are in the public conversation.

I called Chris Funk, the superintendent who removed the paintings. He described the incident as a big misunderstanding.

This was an unfortunate incident that had nothing to do with Mark Harris, Funk said. It was about an employee who didnt have permission to display that work.

Moore didnt receive district approval for the contents of the display before inviting Harris to install his work, Funk said. After Harris left, Funk said he was called out of a meeting because parents and staff members had complained about the works content.

So he took all of it down.

When the public comes into the district office, they have an expectation that they shouldnt be surprised by provocative or political artwork, Funk said. Our responsibility is to provide a safe place for discussion, not to push an agenda.

Den of Iniquity, a mixed-media piece by Mark Harris.

Den of Iniquity, a mixed-media piece by Mark Harris.

I didnt find this convincing, for a few reasons. The first and most obvious reason is that children watch adults in classrooms push agendas each and every day.

The idea of a neutral, idea-free education may be a comforting one for adults, but no child would be naive enough to believe it, and theyre right.

The second reason I found Funks argument unconvincing is the matter of providing the specific students at East Side Union High School District with a safe place for discussion. East Side Union is a majority-minority school district 46 percent of the students are Latino, 34 percent are Asian. Only 8 percent of students are white, as is Funk.

How in the world, I asked him, can you say youre providing those students with a safe place for discussion if the political viewpoints of people of color African Americans, in this case are considered to be too controversial to be admitted?

Funk returned to the idea of a process that hadnt been followed.

The good news is that all of the attention inspired Harris and Funk to sit down and hammer out a solution. At 6:30 p.m. on Wednesday, Feb. 15, the districts office will host a workshop with Harris, the students and their parents.

The workshop is open to all of the districts students, parents and with an RSVP the public. Harris plans to lead the students through a discussion of his work and ask them to talk about their own reactions.

Its a great moment to talk about these issues, and I want the kids to feel empowered to do so, Harris said. Weve been ingrained to not discuss this stuff, and its not healthy.

Tell me about it. If the district officials had been a little more comfortable talking about difficult issues, this entire mess could have been prevented.

Caille Millner is a San Francisco Chronicle staff writer. Email: cmillner@sfchronicle.com Twitter: @caillemillner

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Mob censorship can’t be tolerated – DesMoinesRegister.com

Posted: at 7:44 am

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Sheldon Rabinowitz, Des Moines, Letter to the Editor 6:21 p.m. CT Feb. 10, 2017

Students from City and West High lead protesters down the pedestrian mall during a rally against President Trump's travel ban on Sunday, Feb. 5, 2017.(Photo: David Scrivner/Iowa City Press-Citizen)

If we really have free speech in this country, as provided by law, then any lawful program should be able to be held on any campus. Whether any of us, including university administration or the news media, agree with the sponsors or their subject matter, should have nothing to do with the right to hold the program.

Lawful protest is to be respected, but universities and the local government have the responsibility to protect the people and the property from rioters. Are we to be ruled by anarchists and have mob rule? If the police need to get tough to enforce the law, so be it.

If universities knuckle under threats of rioters, it will only encourage more censorship of what the mob does not want to hear, all across the country.

Sheldon Rabinowitz, Des Moines

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What Wikipedia’s Daily Mail ‘Ban’ Tells Us About The Future Of Online Censorship – Forbes

Posted: at 7:44 am


Forbes
What Wikipedia's Daily Mail 'Ban' Tells Us About The Future Of Online Censorship
Forbes
How was this decision made, what kind of data fed into this decision-making process and what does it tell us about the future of censorship and who decides what is real on the Internet, especially as social media platforms increasingly play the role ...
WP:Reliable sources/Noticeboard - WikipediaWikipedia
Wikipedia bans Daily Mail as 'unreliable' sourceThe Guardian
Wikipedia:Potentially unreliable sources - WikipediaWikipedia

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Ron Paul says likely Deputy Secretary of State Elliott Abrams is ‘the neocon’s neocon’ – Personal Liberty Digest

Posted: at 7:44 am

In a new interview with host Michael Tracey at The Young Turks, libertarian communicator and former presidential candidate Ron Paul expressed much concern about President Donald Trump potentially appointing Elliott Abrams to be deputy secretary of state. Paul says Abrams has a lousy record. Continuing, Paul calls Abrams the neocons neocon, noting that there has never been an intervention overseas that he didnt seem to enjoy.

Paul says in the interview that all of these interventions that Abrams supports did not work. Victory may be claimed in a sense from these interventions, Paul suggests, if they remade the Middle East so we had thriving democracies there where civil liberties are being protected and [each country] had a constitution somewhat leaning toward ours. But, in fact, Paul says that isnt the case as the wars have caused more harm than good.

Indeed, Trump has discussed this failure of US intervention in regard to the Iraq War. Throughout the presidential campaign, Trump brought up his opposition to the United States starting the Iraq War in 2003. In a February of 2016 debate, Trump called the Iraq War a big, fat mistake, a mistake that, Trump continued, cost two trillion dollars and thousands of lives. In addition, Trump asserted that Iran is taking over Iraq, with the second-largest oil reserves in the world. Concluding, Trump said:

George Bush made a mistake. We can make mistakes, but that one was a beauty. We should have never been in Iraq. We have destabilized the Middle East.

Therefore, it surprises many people that reports suggest Trump is considering Abrams for a State Department appointment. Abrams continues to support President George W. Bushs decision to wage war on Iraq.

Watch Pauls complete interview here:

Paul, along with co-host Daniel McAdams, discussed in detail the potentiality of Abrams as deputy secretary of state in the Tuesday episode of the Ron Paul Liberty Report:

In the Ron Paul Liberty Report discussion, Paul argues that Abrams could be one of the most important Trump appointments, and McAdams offers a possible big reason why Trump would want to consider appointing Abrams to the State Department position. McAdams explains that, while people will say that Abrams is so different from Trump, regarding Iran they are in lockstep: Elliott Abrams agrees with Trump and with [Secretary of Defense James Mattis] and with [National Security Advisor Michael Flynn] that Iran is the number one sponsor of terrorism, which is absolutely not true.

For an in-depth discussion by Paul of his views regarding neoconservatism, read here Pauls July 10, 2003 US House of Representatives speech Neo-Conned.

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Ron Paul: Don’t just reform taxes, cut them – Herald & Review

Posted: at 7:44 am

Many Americans who have wrestled with a 1040 form, or who have paid someone to prepare their taxes, no doubt cheered the news that Congress will soon resume working on tax reform. However, taxpayers should temper their enthusiasm because, even in the unlikely event tax collection is simplified, tax reform will not reduce the American people's tax burden.

Congressional leadership's one nonnegotiable requirement of any tax reform is "revenue neutrality." So any tax reform plan that has any chance of even being considered, much less passed, by Congress must ensure that the federal government does not lose a nickel in tax revenue. Congress's obsession with protecting the government's coffers causes reformers to mix tax cuts with tax increases. Congress's insistence on "offsetting" tax cuts with tax increases creates a political food fight where politicians face off over who should have their taxes raised, who should have their taxes cut, and who should have their taxes stay the same.

One offset currently being discussed is an increased tax on imports. This "border adjustment" tax would benefit export-driven industries at the expense of businesses that rely on imported products. A border adjustment tax would harm consumers who use, and retailers who sell, imported goods. The border adjustment tax is another example of politicians using tax reform to pick winners and losers instead of simply reducing everyone's taxes.

When I was in Congress, I was often told that offsets do not raise taxes, they simply close loopholes. This is merely a game of semantics: by removing a way for some Americans to lower their taxes, closing a loophole is clearly a tax increase. While some claim loopholes are another way government distorts the market, I agree with the great economist Ludwig von Mises that "capitalism breathes through loopholes."

By allowing individuals to keep more of their own money, loopholes promote economic efficiency since, as economist Thomas DiLorenzo put it, "private individuals always spend their own money more efficiently than government bureaucrats do." Instead of making the tax system more "efficient" by closing loopholes, Congress should increase both economic efficiency and economic liberty by repealing the income tax and replacing it with nothing.

The revenue loss from ending the income tax should be "offset" with spending cuts. All federal spending, whether financed by taxes or by debt, forcibly removes resources from the private sector. Thus, all government spending is in essence a form of taxation. Therefore, cutting income and other taxes without cutting spending merely replaces one type of taxation with another. Instead of directly paying for big government via income taxes, deficit spending means citizens will be hit with an increase in the inflation tax. This tax, imposed on the people with the Federal Reserve's monetization of debt, is the worst form of tax because it is both hidden and regressive.

Unfortunately, while Congress may make some small cuts in domestic spending, those cuts will be dwarfed by spending increases on infrastructure Keynesianism at home and military Keynesianism abroad. As long as Congress refuses to make serious reductions in spending, the American people will be subject to the tyranny of the IRS and the Federal Reserve.

The suffering will only get worse when concerns over government debt cause the dollar to lose its status as the world reserve currency. This will lead to a dollar crisis and a major economic meltdown. The only way to avoid this fate is for the people to demand a return to limited government in all areas, sound money, and an end to the income tax.

Ron Paul is a former Congressman and Presidential candidate. He can be reached at the RonPaulInstitute.org.

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In my opinion: Ditch the two major parties register Libertarian – Maroon

Posted: at 7:43 am

February 10, 2017 Filed under Op/Ed, Opinions

Back in October, I wrote an editorial urging the Loyola community to check out Libertarian presidential candidate Gary Johnson. The successful entrepreneur turned two-term governor of New Mexico garnered nearly 10 percent of the vote in his home state and 3.3 percent nationally, the most a third party presidential candidate has received since independent Ross Perot 20 years earlier.

OK, Johnson still didnt win and never had a chancewhats your point, Ricardo?

Im so glad you asked.

In 2008, the Libertarian candidate got 523,715 votes or 0.40 percent of the popular vote. In 2012, Gary Johnsons first run for the presidency saw 1,275,971 votes or one percent of the popular vote. And this past election cycle, 4,488,931 American voters thought a Libertarian was a better choice than the Democrat under F.B.I. investigation and the Republican who was a reality TV star Cheeto.

One of the main reasons Johnson didnt have a fair chance was because he, along with Green Party candidate Jill Stein, was excluded from the nationally televised presidential debates. The official reason is that he and Stein didnt have the polling numbers to be admitted.

But the bar gets raised higher and higher. Third party candidates are virtually always excluded.

The debate commission calls itself non-partisan and yet the way it operates benefits the two major parties to the detriment of the American people who deserve to hear another voiceone that might actually reflect what they think and feel.

Many voters are afraid to vote for a third party candidate because of whats called the spoiler effect. They fear that by voting for a less popular candidate who actually represents a majority of their views, they are taking away votes from a more popular candidate who doesnt represent a lot of what they want but is better than another major party candidate who is the polar opposite.

Ralph Nader, who ran as a Green in 2000, is often criticized as stealing the election from Al Gore and enabling George H.W. Bush to win, despite evidence to the contrary.

The takeaway message: research the philosophy of libertarianism, see if you agree and when youre ready to fight the two-party system and promote policies of freedom, register to vote as a Libertarian.

Our national platform states that Libertarians stand for the political freedom of everyone, including our ideological opponents.

For more information, visit the College Libertarians at Loyola University New Orleans Facebook page.

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