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The Differences Between Utilitarianism & Ethical Egoism

Posted: June 7, 2016 at 7:44 pm

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Consequentialism is a moral theory that states that the consequences of one's actions are the basis for any morality or judgment toward that action. Both utilitarianism and ethical egoism are theories within consequentialism that focus on the outcome of conduct as the primary motivation of that action and any critique of whether or not that conduct is ethical. The major difference between utilitarianism and ethical egoism is where those acts are directed.

Utilitarianism focuses on the idea of the greater good. Essentially, this ethical theory intends to maximize good for the the most people. The moral worth of any action is judged by how much good results for all sentient beings. While some individuals may suffer from these actions, utilitarianism holds that the conduct may still be ethical if it does more good for a greater number of people than it harms.

Ethical egoism, also known simply as egoism, holds that moral conduct ought to be judged through self-interest. Egoism states that the good consequences for the individual agent outweigh the consequences placed upon others. In egoism, actions could be considered ethical for the individual if the one taking the action is benefited, while any benefit or detriment to the welfare of others is a side effect and not as important as the consequences for the individual.

The primary differences between these two theories, keeping in mind that there are numerous sub-theories within each branch of thought, is the value placed between the individual and others. In utilitarianism, the most ethical action may be that which harms the individual agent but maximizes the positive impact for the most people overall, essentially placing the emphasis on the whole as opposed to the individual. In egoism, the individual has a greater value than others, thus it is ethical to act in one's own self-interest even if it may potentially harm others.

Utilitarianism seeks to maximize good by minimizing harm to all while egoism seeks to maximize good by keeping the individual happy. In utilitarianism, actions must be judged on the amount of people (or beings) that benefit from the action as opposed to how many the same action may potentially harm. Proponents argue that utilitarianism results in a greater sum of benefit to its harm, based upon outcome and not intention. However, critics of utilitarianism argue that following the interest of the greater good may result in tremendous harm to a large number of individuals.

Meanwhile, egoists argue that acting in self-interest can result in position action because the individual knows best how to benefit his own self, and if everyone were to act in the interest of others, then the general welfare of all would decrease as they are never working for their own good. Egoists trust that others will act in their own interests, thus making it unnecessary to take action solely for their benefit.

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Satanism – Wikipedia, the free encyclopedia

Posted: at 7:44 pm

Satanism is a group of ideological and philosophical beliefs based on the character of Satan.[1] Although the public practice of Satanism began with the founding of the Church of Satan in 1966, historical precedents exist: a group called the Ophite Cultus Satanas was founded in Ohio by Herbert Arthur Sloane in 1948.[2]

Satanist groups that appeared after the 1960s are widely diverse, but two major trends are theistic Satanism and atheistic Satanism. Theistic Satanists venerate Satan as a supernatural deity, viewing him not as omnipotent but rather as a patriarch. In contrast, atheistic Satanists regard Satan as merely a symbol of certain human traits.[3]

There are signs that Satanistic beliefs have become more socially tolerated. Satanism is now allowed in the Royal Navy of the British Armed Forces, despite opposition from Christians,[4][5][6] and in 2005, the Supreme Court of the United States debated over protecting the religious rights of prison inmates after a lawsuit challenging the issue was filed to them.[7][8]

Contemporary Satanism is mainly an American phenomenon, the ideas spreading with the effects of globalization and the Internet.[9] The Internet promotes awareness of other Satanists, and is also the main battleground for the definitions of Satanism today.[9] Satanism started to reach Eastern Europe in the 1990s, in time with the fall of the Soviet Union, and most noticeably in Poland and Lithuania, predominantly Roman Catholic countries.[10][11] It was estimated that there were 50,000 Satanists in 1990. There may now be as many as 100,000 Satanists in the world.[1]

In their study of Satanism, the religious studies scholars Asbjorn Dyrendal, James R. Lewis, and Jesper Aa. Petersen stated that the term "Satanism" "has a history of being a designation made by people against those whom they dislike; it is a term used for "othering"."

Elsewhere, Petersen noted that "Satanism as something others do is very different from Satanism as a self-designation". Eugene Gallagher noted that as commonly used, "Satanism" was usually "a polemical, not a descriptive term".

Historically, some people or groups have been specifically described as worshiping Satan or the Devil, or of being devoted to the work of Satan. The widespread preponderance of these groups in European cultures is in part connected with the importance and meaning of Satan within Christianity.

The Yazidis, a minority religion of the Middle East who worship Melek Taus, are often referred to as Satan worshippers by some Muslims.[28] Due to this, they have been targeted for conversion and extermination by the Islamic State of Iraq and the Levant.[29]

In his history of Satanism, Gareth Medway labelled the Satanic Ritual Abuse hysteria "a rerun of the old witch-hunts".

European Enlightenment, some works, such as Paradise Lost, were taken up by Romantics like Byron and described as presenting the biblical figure of Satan as an allegory representing a crisis of faith, individualism, free will, wisdom and enlightenment.[citation needed] Those works actually featuring Satan as a heroic character are fewer in number but do exist. George Bernard Shaw and Mark Twain (cf. Letters from the Earth) included such characterizations in their works long before religious Satanists took up the pen. From then on, Satan and Satanism started to gain a new meaning outside of Christianity.[9]

Black metal has often been connected with Satanism, in part for the lyrical content of several bands and their frequent use of imagery often tied to left hand path beliefs (such as the inverted pentagram). More often than not musicians associating themselves with black metal say they do not believe in legitimate Satanic ideology and often profess to being atheists, agnostics, or religious skeptics.[31] In some instances, followers of right hand path religions use Satanic references for entertainment purposes and shock value.[32] Most of black metal's "first wave" bands only used Satanism for shock value; one of the few exceptions is Mercyful Fate singer King Diamond, who follows LaVeyan Satanism[33] and whom Michael Moynihan calls "one of the only performers of the '80s Satanic Metal who was more than just a poseur using a devilish image for shock value".[34] One early precursor to Satanic metal was the 1969 rock album Witchcraft Destroys Minds & Reaps Souls, which contained numerous references to Satanism that reappeared in later Satanic rock music.

Glen Benton, vocalist and bassist of the band Deicide, once openly claimed to be a practitioner of theistic Satanism, and has spoken publicly to profess staunch anti-Christian sentiment. The controversial Dissection frontman Jon Ndtveidt openly spoke about his "chaos-gnostic" satanic beliefs, being a member of the Misanthropic Luciferian Order, and called his band "the sonic propaganda unit of the MLO".[35]Norwegian black metal artists such as Euronymous from Mayhem and Infernus from Gorgoroth have also identified themselves as Satanists and actively promoted their beliefs.[36] Numerous church burnings that covered parts of Norway in the early 1990s were also attributed to youths involved in the black metal movement, which included people promoting theistic Satanic beliefs and strong anti-LaVeyan attitudes.[37] However, the legitimacy of such actions as Satanic endeavors, rather than simply rebellious actions done for publicity, is something that has been doubted by even some of those who contribute to the genre.[38]

Rather than being one single form of religious Satanism, there are instead multiple different religious Satanisms, each with different ideas about what being a Satanist entails. Dyrendal, Lewis, and Petersen believed that it was not a single movement, but rather a milieu. They believed that there was a family resemblance that united all of the varying groups in this milieu, and that most of them were self religions. They argued that there were a set of features that were common to the groups in this Satanic milieu: these were the positive use of the term "Satanist" as a designation, an emphasis on individualism, a genealogy that connects them to other Satanic groups, a transgressive and antinomian stance, a self-perception as an elite, and an embrace of values such as pride, self-reliance, and productive non-conformity.

Dyrendal, Lewis, and Petersen argued that the groups within the Satanic milieu could be divided into three groups: reactive Satanists, rationalist Satanists, and esoteric Satanists. They saw reactive Satanism as encompassing "popular Satanism, inverted Christianity, and symbolic rebellion" and noted that it situates itself in opposition to society while at the same time conforming to society's perspective of evil. Rationalist Satanism is used to describe the trend in the Satanic milieu which is atheistic, sceptical, materialistic, and epicurean. Esoteric Satanism instead applied to those forms which are theistic and draw upon ideas from other forms of Western esotericism, Modern Paganism, Buddhism, and Hinduism.

Satanic rhetoric and elements featured in the Third Term of the Trinity, an esoteric group founded in Paris, France in 1935 by the Russian occultist Maria de Naglowska.

Palladists are an alleged theistic Satanist society or member of that society. The name Palladian comes from Pallas and refers to the Greco-Roman goddess of wisdom and learning.

Our Lady of Endor Coven, also known as Ophite Cultus Satanas (originally spelled "Sathanas"), was a satanic cult founded in 1948 by Herbert Arthur Sloane in Toledo, Ohio. The group was heavily influenced by gnosticism (especially that found in the contemporary book by Hans Jonas, The Gnostic Religion), and worshiped Satanas, their name for Satan (Cultus Satanas is a Latin version of Cult of Satan). Satanas (or Satan) was defined in gnostic terms as the Serpent in the Garden of Eden who revealed the knowledge of the true God to Eve. That it called itself "Ophite" is a reference to the ancient gnostic sect of the Ophites, who were said to worship the serpent.

Theistic Satanism (also known as traditional Satanism, Spiritual Satanism or Devil worship) is a form of Satanism with the primary belief that Satan is an actual deity or force to revere or worship.[45][46] Other characteristics of theistic Satanism may include a belief in magic, which is manipulated through ritual, although that is not a defining criterion, and theistic Satanists may focus solely on devotion.

LaVeyan Satanism was founded in 1966 by Anton LaVey through the establishment of the Church of Satan. Its central text, The Satanic Bible, was published in 1969. The fundamentals of the religion's creed are synthesized in The Nine Satanic Statements, The Nine Satanic Sins, and The Eleven Satanic Rules of the Earth. Contrary to popular belief, LaVeyan Satanism does not involve the worship of deities. It is an atheistic philosophy that asserts the individual as his or her own god. Adherents instead see the character of Satan as an archetype of pride, carnality and enlightenment. Adherents to the philosophy have described Satanism as a non-spiritual religion of the flesh, or "...the world's first carnal religion".[48][49]

Luciferianism can be understood best as a belief system or intellectual creed that venerates the essential and inherent characteristics that are affixed and commonly given to Lucifer. Luciferianism is often identified as an auxiliary creed or movement of Satanism, due to the common identification of Lucifer with Satan. Some Luciferians accept this identification and/or consider Lucifer as the "light bearer" and illuminated aspect of Satan, giving them the name of Satanists and the right to bear the title. Others reject it, giving the argument that Lucifer is a more positive and easy-going ideal than Satan. They are inspired by the ancient myths of Egypt, Rome and Greece, Gnosticism and traditional Western occultism.

The Church of Satan was established at the Black House in San Francisco, California, on Walpurgisnacht, April 30, 1966, by Anton Szandor LaVey, who was the church's High Priest until his death in 1997. In 2001, Peter H. Gilmore was appointed to the position of high priest, and the church's headquarters were moved to Hell's Kitchen, Manhattan, New York City. The Church is dedicated to the religion of LaVeyan Satanism as codified in The Satanic Bible. The church rejects the legitimacy of any other organizations who claim to be Satanists.[51][52]

After LaVey's death in 1997, the Church of Satan was taken over by a new administration and its headquarters was moved to New York. LaVey's daughter, the High Priestess Karla LaVey, felt this to be a disservice to her father's legacy. The First Satanic Church was re-founded on October 31, 1999 by Karla LaVey to carry on the legacy of her father. She continues to run it out of San Francisco, California.

The Temple of Set is an initiatory occult society claiming to be the world's leading left-hand path religious organization. It was established in 1975 by Michael A. Aquino and certain members of the priesthood of the Church of Satan,[53] who left because of administrative and philosophical disagreements. ToS deliberately self-differentiates from CoS in several ways, most significantly in theology and sociology.[54] The philosophy of the Temple of Set may be summed up as "enlightened individualism" enhancement and improvement of oneself by personal education, experiment and initiation. This process is necessarily different and distinctive for each individual. The members do not agree on whether Set is "real" or not, and they're not expected to.[54]

Setianism, in theory, is similar to theistic Satanism. The principle deity of Setianism is the ancient Egyptian god Set, or Seth, the god of adversary. Set supposedly is the Dark Lord behind the Hebrew entity Satan. Set, as the first principle of consciousness, is emulated by Setians, who symbolize the concept of individual, subjective intelligence distinct from the natural order as the "Black Flame". (Some people who are not members of the Temple of Set find spiritual inspiration in the Egyptian god Set, and may share some beliefs with the organization. The belief system in general is referred to as Setianism.)

Members of the Temple of Set are mostly male, between the ages of twenty and fifty.[54]

The authors Per Faxneld and Jesper Petersen write that the Order of Nine Angles (ONA, O9A) "represent a dangerous and extreme form of Satanism".[55] The ONA first attracted public attention during the 1980s and 1990s after being mentioned in books detailing fascist Satanism. They were initially formed in the United Kingdom and are presently organized around clandestine cells (which it calls traditional nexions)[56][57] and around what it calls sinister tribes.[58][59]

The Satanic Temple is an American political activist organization based in New York. The organization actively participates in public affairs that have manifested in several public political actions[60][61] and efforts at lobbying,[62] with a focus on the separation of church and state and using satire against Christian groups that it believes interfere with personal freedom.

The Satanic Temple does not believe in a supernatural Satan, as they believe that this encourages superstition that will keep them from being "malleable to the best current scientific understandings of the material world". The Temple uses the literary Satan as metaphor to construct a cultural narrative which promotes pragmatic skepticism, rational reciprocity, personal autonomy, and curiosity.[63] Satan is thus used as a symbol representing "the eternal rebel" against arbitrary authority and social norms.[64][65]

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Hillary Clinton wavers on Second Amendment right to bear arms …

Posted: at 7:42 pm

Hillary Clinton declined to say Sunday whether she believes in a constitutional right to bear arms, possibly opening the door to a fresh round of attacks from Donald Trump, who has already accused the likely Democratic presidential nominee of wanting to "abolish" the Second Amendment.

In an interview on ABC's "This Week," Clinton deflected twice when she was asked whether she agrees with the Supreme Court's interpretation of the Second Amendment. The court ruled in 2008 that the Constitution affords private citizens the right to keep firearms in their homes and that such possession need not be connected to military service.

The wording of the Second Amendment has long made the extent of gun-ownership rights a point of contention.

"A well regulated militia, being necessary to the security of a free state, the right of the people to keep and bear arms, shall not be infringed."

Questioned by George Stephanopoulos about her view of the amendment, Clinton talked about a "nuanced reading" and emphasized her belief in the rights of local, state and federal governments to regulate gun ownership. Stephanopoulos, formerly a top aide to President Bill Clinton, wasn't satisfied by the response.

"That's not what I asked," he replied.

Clinton then discussed the right to own a gun as a hypothetical. "If it is a constitutional right," she began her next answer, "then it like every other constitutional right is subject to reasonable regulations."

Here's the full exchange:

STEPHANOPOULOS: Let's talk about the Second Amendment. As you know, Donald Trump has also been out on the stump talking about the Second Amendment and saying you want to abolish the Second Amendment. I know you reject that. But I want to ask you a specific question: Do you believe that an individual's right to bear arms is a constitutional right that it's not linked to service in a militia?

CLINTON: I think that for most of our history there was a nuanced reading of the Second Amendment until the decision by the late Justice [Antonin] Scalia. And there was no argument until then that localities and states and the federal government had a right as we do with every amendment to impose reasonable regulations. So I believe we can have common-sense gun-safety measures consistent with the Second Amendment. And, in fact, what I have proposed is supported by 90 percent of the American people and more than 75 percent of responsible gun owners. So that is exactly what I think is constitutionally permissible and, once again, you have Donald Trump just making outright fabrications, accusing me of something that is absolutely untrue. But I'm going to continue to speak out for comprehensive background checks; closing the gun-show loophole; closing the online loophole; closing the so-called Charleston loophole;reversing the bill that Senator[Bernie] Sanders voted for and I voted against, giving immunity from liability to gun makers and sellers. I think all of that can and should be done, and it is, in my view, consistent with the Constitution.

STEPHANOPOULOS: And, and the Heller decision also says there can be some restrictions. But that's not what I asked. I said, "Do you believe their conclusion that the right to bear arms is a constitutional right?"

CLINTON: If it is a constitutional right, then it like every other constitutional right is subject to reasonable regulations. And what people have done with that decision is to take it as far as they possibly can and reject what has been our history from the very beginning of the republic, where some of the earliest laws that were passed were about firearms. So I think it's important to recognize that reasonable people can say, as I do, responsible gun owners have a right. I have no objection to that. But the rest of the American public has a right to require certain kinds of regulatory, responsible actions to protect everyone else.

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Ignatius of Antioch: The Medicine of Immortality, and the …

Posted: at 7:40 pm

Let my spirit be counted as nothing for the sake of the cross, which is a stumbling-block to those that do not believe, but to us salvation and life eternal.

Where is the wise man? where the disputer? Where is the boasting of those who are styled prudent?

For our God, Jesus Christ, was, according to the appointment of God, conceived in the womb by Mary, of the seed of David, but by the Holy Ghost.

He was born and baptized, that by His passion He might purify the water.

Now the virginity of Mary was hidden from the prince of this world, as was also her offspring, and the death of the Lord; three mysteries of renown, which were wrought in silence by God.

How, then, was He manifested to the world? A star shone forth in heaven above all the other stars, the light of Which was inexpressible, while its novelty struck men with astonishment.

And all the rest of the stars, with the sun and moon, formed a chorus to this star, and its light was exceedingly great above them all. And there was agitation felt as to whence this new spectacle came, so unlike to everything else in the heavens.

Hence every kind of magic was destroyed, and every bond of wickedness disappeared; ignorance was removed, and the old kingdom abolished, God Himself being manifested in human form for the renewal of eternal life.

And now that took a beginning which had been prepared by God. Henceforth all things were in a state of tumult, because He meditated the abolition of death.

If Jesus Christ shall graciously permit me through your prayers, and if it be His will, I shall, in a second little work which I will write to you, make further manifest to you the nature of the dispensation of which I have begun to treat, with respect to the new man, Jesus Christ, in His faith and in His love, in His suffering and in His resurrection.

Especially will I do this if the Lord make known to me that you come together in common, man by man, through grace individually, in one faith, and in Jesus Christ, who was of the seed of David according to the flesh, being both the Son of man and the Son of God;

and if you thus obey the bishop and the presbytery with an undivided mind, breaking one and the same bread, which is the medicine of immortality, and the antidote to prevent us from dying, but which causes that we should live for ever in Jesus Christ.

Ignatius of Antioch (c. 35 c. 107): Letter to the Ephesians, 18-20 @ Crossroads Initiative.

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The Patriot Post Shop – 2A – Second Amendment

Posted: at 9:43 am

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Rationalism, Continental | Internet Encyclopedia of Philosophy

Posted: June 6, 2016 at 4:45 pm

Continental rationalism is a retrospective category used to group together certain philosophers working in continental Europe in the 17th and 18th centuries, in particular, Descartes, Spinoza, and Leibniz, especially as they can be regarded in contrast with representatives of British empiricism, most notably, Locke, Berkeley, and Hume. Whereas the British empiricists held that all knowledge has its origin in, and is limited by, experience, the Continental rationalists thought that knowledge has its foundation in the scrutiny and orderly deployment of ideas and principles proper to the mind itself. The rationalists did not spurn experience as is sometimes mistakenly alleged; they were thoroughly immersed in the rapid developments of the new science, and in some cases led those developments. They held, however, that experience alone, while useful in practical matters, provides an inadequate foundation for genuine knowledge.

The fact that Continental rationalism and British empiricism are retrospectively applied terms does not mean that the distinction that they signify is anachronistic. Leibnizs New Essays on Human Understanding, for instance, outlines stark contrasts between his own way of thinking and that of Locke, which track many features of the rationalist/empiricist distinction as it tends to be applied in retrospect. There was no rationalist creed or manifesto to which Descartes, Spinoza, and Leibniz all subscribed (nor, for that matter, was there an empiricist one). Nevertheless, with due caution, it is possible to use the Continental rationalism category (and its empiricist counterpart) to highlight significant points of convergence in the philosophies of Descartes, Spinoza, and Leibniz, inter alia. These include: (1) a doctrine of innate ideas; (2) the application of mathematical method to philosophy; and (3) the use of a priori principles in the construction of substance-based metaphysical systems.

According to the Historisches Worterbuch der Philosophie, the word rationaliste appears in 16th century France, as early as 1539, in opposition to empirique. In his New Organon, first published in 1620 (in Latin), Francis Bacon juxtaposes rationalism and empiricism in memorable terms:

Those who have treated of the sciences have been either empiricists [Empirici] or dogmatists [Dogmatici]. Empiricists [Empirici], like ants, simply accumulate and use; Rationalists [Rationales], like spiders, spin webs from themselves; the way of the bee is in between: it takes material from the flowers of the garden and the field; but it has the ability to convert and digest them. (The New Organon, p. 79; Spedding, 1, 201)

Bacons association of rationalists with dogmatists in this passage foreshadows Kants use of the term dogmatisch in reference, especially, to the Wolffian brand of rationalist philosophy prevalent in 18th century Germany. Nevertheless, Bacons use of rationales does not refer to Continental rationalism, which developed only after the New Organon, but rather to the Scholastic philosophy that dominated the medieval period. Moreover, while Bacon is, in retrospect, often considered the father of modern empiricism, the above-quoted passage shows him no friendlier to the empirici than to the rationales. Thus, Bacons juxtaposition of rationalism and empiricism should not be confused with the distinction as it develops over the course of the 17th and 18th centuries, although his imagery is certainly suggestive.

The distinction appears in an influential form as the backdrop to Kants critical philosophy (which is often loosely understood as a kind of synthesis of certain aspects of Continental rationalism and British empiricism) at the end of the 18th century. However, it was not until the time of Hegel in the first half of the 19th century that the terms rationalism and empiricism were applied to separating the figures of the 17th and 18th centuries into contrasting epistemological camps in the fashion with which we are familiar today. In his Lectures on the History of Philosophy, Hegel describes an opposition between a priori thought, on the one hand, according to which the determinations which should be valid for thought should be taken from thought itself, and, on the other hand, the determination that we must begin and end and think, etc., from experience. He describes this as the opposition between Rationalismus and Empirismus (Werke 20, 121).

Perhaps the best recognized and most commonly made distinction between rationalists and empiricists concerns the question of the source of ideas. Whereas rationalists tend to think (with some exceptions discussed below) that some ideas, at least, such as the idea of God, are innate, empiricists hold that all ideas come from experience. Although the rationalists tend to be remembered for their positive doctrine concerning innate ideas, their assertions are matched by a rejection of the notion that all ideas can be accounted for on the basis of experience alone. In some Continental rationalists, especially in Spinoza, the negative doctrine is more apparent than the positive. The distinction is worth bearing in mind, in order to avoid the very false impression that the rationalists held to innate ideas because the empiricist alternative had not come along yet. (In general, the British empiricists came after the rationalists.) The Aristotelian doctrine, nihil in intellectu nisi prius in sensu (nothing in the intellect unless first in the senses), had been dominant for centuries, and it was in reaction against this that the rationalists revived in modified form the contrasting Platonic doctrine of innate ideas.

Descartes distinguishes between three kinds of ideas: adventitious (adventitiae), factitious (factae), and innate (innatae). As an example of an adventitious idea, Descartes gives the common idea of the sun (yellow, bright, round) as it is perceived through the senses. As an example of a factitious idea, Descartes cites the idea of the sun constructed via astronomical reasoning (vast, gaseous body). According to Descartes, all ideas which represent true, immutable, and eternal essences are innate. Innate ideas, for Descartes, include the idea of God, the mind, and mathematical truths, such as the fact that it pertains to the nature of a triangle that its three angles equal two right angles.

By conceiving some ideas as innate, Descartes does not mean that children are born with fully actualized conceptions of, for example, triangles and their properties. This is a common misconception of the rationalist doctrine of innate ideas. Descartes strives to correct it in Comments on a Certain Broadsheet, where he compares the innateness of ideas in the mind to the tendency which some babies are born with to contract certain diseases: it is not so much that the babies of such families suffer from these diseases in their mothers womb, but simply that they are born with a certain faculty or tendency to contract them (CSM I, 304). In other words, innate ideas exist in the mind potentially, as tendencies; they are then actualized by means of active thought under certain circumstances, such as seeing a triangular figure.

At various points, Descartes defends his doctrine of innate ideas against philosophers (Hobbes, Gassendi, and Regius, inter alia) who hold that all ideas enter the mind through the senses, and that there are no ideas apart from images. Descartes is relatively consistent on his reasons for thinking that some ideas, at least, must be innate. His principal line of argument proceeds by showing that there are certain ideas, for example, the idea of a triangle, that cannot be either
adventitious or factitious; since ideas are either adventitious, factitious, or innate, by process of elimination, such ideas must be innate.

Take Descartes favorite example of the idea of a triangle. The argument that the idea of a triangle cannot be adventitious proceeds roughly as follows. A triangle is composed of straight lines. However, straight lines never enter our mind via the senses, since when we examine straight lines under a magnifying lens, they turn out to be wavy or irregular in some way. Since we cannot derive the idea of straight lines from the senses, we cannot derive the idea of a true triangle, which is made up of straight lines, through the senses. Sometimes Descartes makes the point in slightly different terms by insisting that there is no similarity between the corporeal motions of the sense organs and the ideas formed in the mind on the occasion of those motions (CSM I, 304; CSMK III, 187). One such dissimilarity, which is particularly striking, is the contrast between the particularity of all corporeal motions and the universality that pure ideas can attain when conjoined to form necessary truths. Descartes makes this point in clear terms to Regius:

I would like our author to tell me what the corporeal motion is that is capable of forming some common notion to the effect that things which are equal to a third thing are equal to each other, or any other he cares to take. For all such motions are particular, whereas the common notions are universal and bear no affinity with, or relation to, the motions. (CSM I, 304-5)

Next, Descartes has to show that the idea of a triangle is not factitious. This is where the doctrine of true and immutable natures comes in. For Descartes, if, for example, the idea that the three angles of a triangle are equal to two right angles were his own invention, it would be mutable, like the idea of a gold mountain, which can be changed at whim into the idea of a silver mountain. Instead, when Descartes thinks about his idea of a triangle, he is able to discover eternal properties of it that are not mutable in this way; hence, they are not invented (CSMK III, 184).

Since, therefore, the triangle can be neither adventitious nor factitious, it must be innate; that is to say, the mind has an innate tendency or power to form this idea from its own purely intellectual resources when prompted to do so.

Descartes insistence that there is no similarity between the corporeal motions of our sense organs and the ideas formed in the mind on the occasion of those motions raises a difficulty for understanding how any ideas could be adventitious. Since none of our ideas have any similarity to the corporeal motions of the sense organs even the idea of motion itself it seems that no ideas can in fact have their origin in a source external to the mind. The reason that we have an idea of heat in the presence of fire, for instance, is not, then, because the idea is somehow transmitted by the fire. Rather, Descartes thinks that God designed us in such a way that we form the idea of heat on the occasion of certain corporeal motions in our sense organs (and we form other sensory ideas on the occasion of other corporeal motions). Thus, there is a sense in which, for Descartes, all ideas are innate, and his tripartite division between kinds of ideas becomes difficult to maintain.

Per his so-called doctrine of parallelism, Spinoza conceives the mind and the body as one and the same thing, conceived under different attributes (to wit, thought and extension). (See Benedict de Spinoza: Metaphysics.) As a result, Spinoza denies that there is any causal interaction between mind and body, and so Spinoza denies that any ideas are caused by bodily change. Just as bodies can be affected only by other bodies, so ideas can be affected only by other ideas. This does not mean, however, that all ideas are innate for Spinoza, as they very clearly are for Leibniz (see below). Just as the body can be conceived to be affected by external objects conceived under the attribute of extension (that is, as bodies), so the mind can (as it were, in parallel) be conceived to be affected by the same objects conceived under the attribute of thought (that is, as ideas). Ideas gained in this way, from encounters with external objects (conceived as ideas) constitutes knowledge of the first kind, or imagination, for Spinoza, and all such ideas are inadequate, or in other words, confused and lacking order for the intellect. Adequate ideas, on the other hand, which can be formed via Spinozas second and third kinds of knowledge (reason and intuitive knowledge, respectively), and which are clear and distinct and have order for the intellect, are not gained through chance encounters with external objects; rather, adequate ideas can be explained in terms of resources intrinsic to the mind. (For more on Spinozas three kinds of knowledge and the distinction between adequate and inadequate ideas, see Benedict de Spinoza: Epistemology.)

The mind, for Spinoza, just by virtue of having ideas, which is its essence, has ideas of what Spinoza calls common notions, or in other words, those things which are equally in the part and in the whole. Examples of common notions include motion and rest, extension, and indeed God. Take extension for example. To think of any body however small or however large is to have a perfectly complete idea of extension. So, insofar as the mind has any idea of body (and, for Spinoza, the human mind is the idea of the human body, and so always has ideas of body), it has a perfectly adequate idea of extension. The same can be said for motion and rest. The same can also be said for God, except that God is not equally in the part and in the whole of extension only, but of all things. Spinoza treats these common notions as principles of reasoning. Anything that can be deduced on their basis is also adequate.

It is not clear if Spinozas common notions should be considered innate ideas. Spinoza speaks of active and passive ideas, and adequate and inadequate ideas. He associates the former with the intellect and the latter with the imagination, but innate idea is not an explicit category in Spinozas theory of ideas as it is in Descartes and also Leibnizs. Common notions are not in the mind independent of the minds relation with its object (the body); nevertheless, since it is the minds nature to be the idea of the body, it is part of the minds nature to have common notions. Commentators differ over the question of whether Spinoza had a positive doctrine of innate ideas; it is clear, however, that he denied that all ideas come about through encounters with external objects; moreover, he believed that those ideas which do come about through encounters with external objects are of an inferior epistemic value than those produced through the minds own intrinsic resources; this is enough to put him in the rationalist camp on the question of the origin of ideas.

Of the three great rationalists, Leibniz propounded the most thoroughgoing doctrine of innate ideas. For Leibniz, all ideas are strictly speaking innate. In a general and relatively straightforward sense, this viewpoint is a direct consequence of Leibnizs conception of individual substance. According to Leibniz, each substance is a world apart, independent of everything outside of itself except for God. Thus all our phenomena, that is to say, all the things that can ever happen to us, are only the results of our own being (L, 312); or, in Leibnizs famous phrase from the Monadology, monads have no windows, meaning there is no way for sensory data to enter monads from the outside. In this more general sense, then, to give a
n explanation for Leibnizs doctrine of innate ideas would be to explain his conception of individual substance and the arguments and considerations which motivate it. (See Section 4, b, iii, below for a discussion of Leibnizs conception of substance; see also Gottfried Leibniz: Metaphysics.) This would be to circumvent the issues and questions which are typically at the heart of the debate over the existence of innate ideas, which concern the extent to which certain kinds of perceptions, ideas, and propositions can be accounted for on the basis of experience. Although Leibnizs more general reasons for embracing innate ideas stem from his unique brand of substance metaphysics, Leibniz does enter into the debate over innate ideas, as it were, addressing the more specific questions regarding the source of given kinds of ideas, most notably in his dialogic engagement with Lockes philosophy, New Essays on Human Understanding.

Due to Leibnizs conception of individual substance, nothing actually comes from a sensory experience, where a sensory experience is understood to involve direct concourse with things outside of the mind. However, Leibniz does have a means for distinguishing between sensations and purely intellectual thoughts within the framework of his substance metaphysics. For Leibniz, although each monad or individual substance expresses (or represents) the entire universe from its own unique point of view, it does so with a greater or lesser degree of clarity and distinctness. Bare monads, such as comprise minerals and vegetation, express the rest of the world only in the most confused fashion. Rational minds, by contrast, have a much greater proportion of clear and distinct perceptions, and so express more of the world clearly and distinctly than do bare monads. When an individual substance attains a more perfect expression of the world (in the sense that it attains a less confused expression of the world), it is said to act; when its expression becomes more confused, it is said to be acted upon. Using this distinction, Leibniz is able to reconcile the terms of his philosophy with everyday conceptions. Although, strictly speaking, no monad is acted upon by any other, nor acts upon any other directly, it is possible to speak this way, just as, Leibniz says, Copernicans can still speak of the motion of the sun for everyday purposes, while understanding that the sun does not in fact move. It is in this sense that Leibniz enters into the debate concerning the origin of our ideas.

Leibniz distinguishes between ideas (ides) and thoughts (penses) (or, sometimes, notions (notions) or concepts (conceptus)). Ideas exist in the soul whether we actually perceive them or are aware of them or not. It is these ideas that Leibniz contends are innate. Thoughts, by contrast is Leibnizs designation for ideas which we actually form or conceive at any given time. In this sense, thoughts can be formed on the basis of a sensory experience (with the above caveats regarding the meaning a sensory experience can have in Leibnizs thought) or on the basis of an internal experience, or a reflection. Leibniz alternatively characterizes our ideas as aptitudes, preformations, and as dispositions to represent something when the occasion for thinking of it arises. On multiple occasions, Leibniz uses the metaphor of the veins present in marble to illustrate his understanding of innate ideas. Just as the veins dispose the sculptor to shape the marble in certain ways, so do our ideas dispose us to have certain thoughts on the occasion of certain experiences.

Leibniz rejects the view that the mind cannot have ideas without being aware that it has them. (See Gottfried Leibniz: Philosophy of Mind.) Much of the disagreement between Locke and Leibniz on the question of innate ideas turns on this point, since Locke (at least as Leibniz represents him in the New Essays) is not able to make any sense out of the notion that the mind can have ideas without being aware of them. Much of Leibnizs defense of his innate ideas doctrine takes the form of replying to Lockes charge that it is absurd to hold that the mind could think (that is, have ideas) without being aware of it.

Leibniz marshals several considerations in support of his view that the mind is not always aware of its ideas. The fact that we can store many more ideas in our understanding than we can be aware of at any given time is one. Leibniz also points to the phenomenology of attention; we do not attend to everything in our perceptual field at any given time; rather we focus on certain things at the expense of others. To convey a sense of what it might be like for the mind to have perceptions and ideas in a dreamless sleep, Leibniz asks the reader to imagine subtracting our attention from perceptual experience; since we can distinguish between what is attended to and what is not, subtracting attention does not eliminate perception altogether.

While such considerations suggest the possibility of innate ideas, they do not in and of themselves prove that innate ideas are necessary to explain the full scope of human cognition. The empiricist tends to think that if innate ideas are not necessary to explain cognition, then they should be abandoned as gratuitous metaphysical constructs. Leibniz does have arguments designed to show that innate ideas are needed for a full account of human cognition.

In the first place, Leibniz recalls favorably the famous scenario from Platos Meno where Socrates teaches a slave boy to grasp abstract mathematical truths merely by asking questions. The anecdote is supposed to indicate that mathematical truths can be generated by the mind alone, in the absence of particular sensory experiences, if only the mind is prompted to discover what it contains within itself. Concerning mathematics and geometry, Leibniz remarks: one could construct these sciences in ones study and even with ones eyes closed, without learning from sight or even from touch any of the needed truths (NE, 77). So, on these grounds, Leibniz contends that without innate ideas, we could not explain the sorts of cognitive capacities exhibited in the mathematical sciences.

A second argument concerns our capacity to grasp certain necessary or eternal truths. Leibniz says that necessary truths can be suggested, justified, and confirmed by experience, but that they can be proved only by the understanding alone (NE, 80). Leibniz does not explain this point further, but he seems to have in mind the point later made by both Hume and Kant (to different ends), that experience on its own can never account for the kind of certainty that we find in mathematical and metaphysical truths. For Leibniz, if it can be granted that we can be certain of propositions in mathematics and metaphysics and Leibniz thinks this must be granted recourse must be had to principles innate to the mind in order to explain our ability to be certain of such things.

It is worth noting briefly the position of Nicolas Malebranche on innate ideas, since Malebranche is often considered among the rationalists, yet he denied the doctrine of innate ideas. Malebranches reasons for rejecting innate ideas were anything but empiricist in nature, however. His leading objection stems from the infinity of ideas that the mind is able to form independently of the senses; as an example, Malebranche cites the infinite number of triangles of which the mind could in principle, albeit not in practice, form ideas. Unlike Descartes and Leibniz, who view innate ideas as tendencies or dispositions to form certain thoughts under certain circumstances, Malebranche understands them as fully formed entities that would have to exist somehow
in the mind were they to exist there innately. Given this conception, Malebranche finds it unlikely that God would have created so many things along with the mind of man (The Search After Truth, p. 227). Since God already contains the ideas of all things within Himself, Malebranche thinks that it would be much more economical if God were simply to reveal to us the ideas of things that already exist in him rather than placing an infinity of ideas in each human mind. Malebranches tenet that we see all things in God thus follows upon the principle that God always acts in the simplest ways. Malebranche finds further support for this doctrine from the fact that it places human minds in a position of complete dependence on God. Thus, if Malebranches rejection of innate ideas distinguishes him from other rationalists, it does so not from an empiricist standpoint, but rather because of the extent to which his position on ideas is theologically motivated.

In one sense, what it means to be a rationalist is to model philosophy on mathematics, and, in particular, geometry. This means that the rationalist begins with definitions and intuitively self-evident axioms and proceeds thence to deduce a philosophical system of knowledge that is both certain and complete. This at least is the goal and (with some qualifications to be explored below) the claim. In no work of rationalist philosophy is this procedure more apparent than in Spinozas Ethics, laid out famously in the geometrical manner (more geometrico). Nevertheless, Descartes main works (and those of Leibniz as well), although not as overtly more geometrico as Spinozas Ethics, are also modelled after geometry, and it is Descartes celebrated methodological program that first introduces mathematics as a model for philosophy.

Perhaps Descartes clearest and most well-known statement of mathematics role as paradigm appears in the Discourse on the Method:

Those long chains of very simple and easy reasonings, which geometers customarily use to arrive at their most difficult demonstrations, had given me occasion to suppose that all the things which can fall under human knowledge are interconnected in the same way. (CSM I, 120)

However, Descartes promotion of mathematics as a model for philosophy dates back to his early, unfinished work, Rules for the Direction of the Mind. It is in this work that Descartes first outlines his standards for certainty that have since come to be so closely associated with him and with the rationalist enterprise more generally.

In Rule 2, Descartes declares that henceforth only what is certain should be valued and counted as knowledge. This means the rejection of all merely probable reasoning, which Descartes associates with the philosophy of the Schools. Descartes admits that according to this criterion, only arithmetic and geometry thus far count as knowledge. But Descartes does not conclude that only in these disciplines is it possible to attain knowledge. According to Descartes, the reason that certainty has eluded philosophers has as much to do with the disdain that philosophers have for the simplest truths as it does with the subject matter. Admittedly, the objects of arithmetic and geometry are especially pure and simple, or, as Descartes will later say, clear and distinct. Nevertheless, certainty can be attained in philosophy as well, provided the right method is followed.

Descartes distinguishes between two ways of achieving knowledge: through experience and through deduction [] [W]e must note that while our experiences of things are often deceptive, the deduction or pure inference of one thing from another can never be performed wrongly by an intellect which is in the least degree rational [] (CSM I, 12). This is a clear statement of Descartes methodological rationalism. Building up knowledge through accumulated experience can only ever lead to the sort of probable knowledge that Descartes finds lacking. Pure inference, by contrast, can never go astray, at least when it is conducted by right reason. Of course, the truth value of a deductive chain is only as good as the first truths, or axioms, whose truth the deductions preserve. It is for this reason that Descartes method relies on intuition as well as deduction. Intuition provides the first principles of a deductive system, for Descartes. Intuition differs from deduction insofar as it is not discursive. Intuition grasps its object in an immediate way. In its broadest outlines, Descartes method is just the use of intuition and deduction in the orderly attainment and preservation of certainty.

In subsequent Rules, Descartes goes on to elaborate a more specific methodological program, which involves reducing complicated matters step by step to simpler, intuitively graspable truths, and then using those simple truths as principles from which to deduce knowledge of more complicated matters. It is generally accepted by scholars that this more specific methodological program reappears in a more iconic form in the Discourse on the Method as the four rules for gaining knowledge outlined in Part 2. There is some doubt as to the extent to which this more specific methodological program actually plays any role in Descartes mature philosophy as it is expressed in the Meditations and Principles (see Garber 2001, chapter 2). There can be no doubt, however, that the broader methodological guidelines outlined above were a permanent feature of Descartes thought.

In response to a request to cast his Meditations in the geometrical style (that is, in the style of Euclids Elements), Descartes distinguishes between two aspects of the geometrical style: order and method, explaining:

The order consists simply in this. The items which are put forward first must be known entirely without the aid of what comes later; and the remaining items must be arranged in such a way that their demonstration depends solely on what has gone before. I did try to follow this order very carefully in my Meditations [] (CSM II, 110)

Elsewhere, Descartes contrasts this order, which he calls the order of reasons, with another order, which he associates with scholasticism, and which he calls the order of subject-matter (see CSMK III, 163). What Descartes understands as geometrical order or the order of reasons is just the procedure of starting with what is most simple, and proceeding in a step-wise, deliberate fashion to deduce consequences from there. Descartes order is governed by what can be clearly and distinctly intuited, and by what can be clearly and distinctly inferred from such self-evident intuitions (rather than by a concern for organizing the discussion into neat topical categories per the order of subject-matter)

As for method, Descartes distinguishes between analysis and synthesis. For Descartes, analysis and synthesis represent different methods of demonstrating a conclusion or set of conclusions. Analysis exhibits the path by which the conclusion comes to be grasped. As such, it can be thought of as the order of discovery or order of knowledge. Synthesis, by contrast, wherein conclusions are deduced from a series of definitions, postulates, and axioms, as in Euclids Elements, for instance, follows not the order in which things are discovered, but rather the order that things bear to one another in reality. As such, it can be thought of as the order of being. God, for example, is prior to the human mind in the order of being (since God created the human mind), and so in the synthetic mode of demonstration the existence of God is demonstrated before the existence of the human mind. However, knowledge of ones own mind precedes knowledge of God, at least in D
escartes philosophy, and so in the analytic mode of demonstration the cogito is demonstrated before the existence of God. Descartes preference is for analysis, because he thinks that it is superior in helping the reader to discover the things for herself, and so in bringing about the intellectual conversion which it is the Meditations goal to effectuate in the minds of its readers. According to Descartes, while synthesis, in laying out demonstrations systematically, is useful in preempting dissent, it is inferior in engaging the mind of the reader.

Two primary distinctions can be made in summarizing Descartes methodology: (1) the distinction between the order of reasons and the order of subject-matter; and (2) the analysis/synthesis distinction. With respect to the first distinction, the great Continental rationalists are united. All adhere to the order of reasons, as we have described it above, rather than the order of subject-matter. Even though the rationalists disagree about how exactly to interpret the content of the order of reasons, their common commitment to following an order of reasons is a hallmark of their rationalism. Although there are points of convergence with respect to the second, analysis/synthesis distinction, there are also clear points of divergence, and this distinction can be useful in highlighting the range of approaches the rationalists adopt to mathematical methodology.

Of the great Continental rationalists, Spinoza is the most closely associated with mathematical method due to the striking presentation of his magnum opus, the Ethics, (as well as his presentation of Descartes Principles), in geometrical fashion. The fact that Spinoza is the only major rationalist to present his main work more geometrico might create the impression that he is the only philosopher to employ mathematical method in constructing and elaborating his philosophical system. This impression is mistaken, since both Descartes and Leibniz also apply mathematical method to philosophy. Nevertheless, there are differences between Spinozas employment of mathematical method and that of Descartes (and Leibniz). The most striking, of course, is the form of Spinozas Ethics. Each part begins with a series of definitions, axioms, and postulates and proceeds thence to deduce propositions, the demonstrations of which refer back to the definitions, axioms, postulates and previously demonstrated propositions on which they depend. Of course, this is just the method of presenting findings that Descartes in the Second Replies dubbed synthesis. For Descartes, analysis and synthesis differ only in pedagogical respects: whereas analysis is better for helping the reader discover the truth for herself, synthesis is better in compelling agreement.

There is some evidence that Spinozas motivations for employing synthesis were in part pedagogical. In Lodewijk Meyers preface to Spinozas Principles of Cartesian Philosophy, Meyer uses Descartes Second Replies distinction between analysis and synthesis to explain the motivation for the work. Meyer criticizes Descartes followers for being too uncritical in their enthusiasm for Descartes thought, and attributes this in part to the relative opacity of Descartes analytic mode of presentation. Thus, for Meyer, the motivation for presenting Descartes Principles in the synthetic manner is to make the proofs more transparent, and thereby leave less excuse for blind acceptance of Descartes conclusions. It is not clear to what extent Meyers explanation of the mode of presentation of Spinozas Principles of Cartesian Philosophy applies to Spinozas Ethics. In the first place, although Spinoza approved the preface, he did not author it himself. Secondly, while such an explanation seems especially suited to a work in which Spinozas chief goal was to present another philosophers thought in a different form, there is no reason to assume that it applies to the presentation of Spinozas own philosophy. Scholars have differed on how to interpret the geometrical form of Spinozas Ethics. However, it is generally accepted that Spinozas use of synthesis does not merely represent a pedagogical preference. There is reason to think that Spinozas methodology differs from that of Descartes in a somewhat deeper way.

There is another version of the analysis/synthesis distinction besides Descartes that was also influential in the 17th century, that is, Hobbes version of the distinction. Although there is little direct evidence that Spinoza was influenced by Hobbes version of the distinction, some scholars have claimed a connection, and, in any case, it is useful to view Spinozas methodology in light of the Hobbesian alternative.

Synthesis and analysis are not modes of demonstrating findings that have already been made, for Hobbes, as they are for Descartes, but rather complementary means of generating findings; in particular, they are forms of causal reasoning. For Hobbes, analysis is reasoning from effects to causes; synthesis is reasoning in the other direction, from causes to effects. For example, by analysis, we infer that geometrical objects are constructed via the motions of points and lines and surfaces. Once motion has been established as the principle of geometry, it is then possible, via synthesis, to construct the possible effects of motion, and thereby, to make new discoveries in geometry. According to the Hobbesian schema, then, synthesis is not merely a mode of presenting truths, but a means of generating and discovering truths. (For Hobbes method, see The English Works of Thomas Hobbes of Malmesbury, vol. 1, ch. 6.) There is reason to think that synthesis had this kind of significance for Spinoza, as well as a means of discovery, not merely presentation. Spinozas methodology, and, in particular, his theory of definitions, bear this out

Spinozas method begins with reflection on the nature of a given true idea. The given true idea serves as a standard by which the mind learns the distinction between true and false ideas, and also between the intellect and the imagination, and how to direct itself properly in the discovery of true ideas. The correct formulation of definitions emerges as the most important factor in directing the mind properly in the discovery of true ideas. To illustrate his conception of a good definition, Spinoza contrasts two definitions of a circle. On one definition, a circle is a figure in which all the lines from the center to the circumference are equal. On another, a circle is the figure described by the rotation of a line around one of its ends, which is fixed. For Spinoza, the second definition is superior. Whereas the first definition gives only a property of the circle, the second provides the cause from which all of the properties can be deduced. Hence, what makes a definition a good definition, for Spinoza, is its capacity to serve as a basis for the discovery of truths about the thing. The circle, of course, is just an example. For Spinoza, the method is perfected when it arrives at a true idea of the first cause of all things, that is, God. Only the method is perfected with a true idea of God, however, not the philosophy. The philosophy itself begins with a true idea of God, since the philosophy consists in deducing the consequences from a true idea of God. With this in mind, the definition of God is of paramount importance. In correspondence, Spinoza compares contrasting definitions of God, explaining that he chose the one which expresses the efficient cause from which all of the properties of God can be deduced.

In this light, it becomes clear that the geometrical presentation of Spinozas philosophy is not merely a pedagogic preference. The definitions
that appear at the outset of the five parts of the Ethics do not serve merely to make explicit what might otherwise have remained only implicit in Descartes analytic mode of presentation. Rather, key definitions, such as the definition of God, are principles that underwrite the development of the system. As a result, Hobbes conception of the analysis/synthesis distinction throws an important light on Spinozas procedure. There is a movement of analysis in arriving at the causal definition of God from the preliminary given true idea. Then there is a movement of synthesis in deducing consequences from that causal definition. Of course, Descartes analysis/synthesis distinction still applies, since, after all, Spinozas system is presented in the synthetic manner in the Ethics. But the geometrical style of presentation is not merely a pedagogical device in Spinozas case. It is also a clue to the nature of his system.

Leibniz is openly critical of Descartes distinction between analysis and synthesis, writing, Those who think that the analytic presentation consists in revealing the origin of a discovery, the synthetic in keeping it concealed, are in error (L, 233). This comment is aimed at Descartes formulation of the distinction in the Second Replies. Leibniz is explicit about his adherence to the viewpoint that seems to be implied by Spinozas methodology: synthesis is itself a means of discovering truth no less than analysis, not merely a mode of presentation. Leibnizs understanding of analysis and synthesis is closer to the Hobbesian conception, which views analysis and synthesis as different directions of causal reasoning: from effects to causes (analysis) and from causes to effects (synthesis). Leibniz formulates the distinction in his own terms as follows:

Synthesis is achieved when we begin from principles and run through truths in good order, thus discovering certain progressions and setting up tables, or sometimes general formulas, in which the answers to emerging questions can later be discovered. Analysis goes back to the principles in order to solve the given problems only [] (L, 232)

Leibniz thus conceives synthesis and analysis in relation to principles.

Leibniz lays great stress on the importance of establishing the possibility of ideas, that is to say, establishing that ideas do not involve contradiction, and this applies a fortiori to first principles. For Leibniz, the Cartesian criterion of clear and distinct perception does not suffice for establishing the possibility of an idea. Leibniz is critical, in particular, of Descartes ontological argument on the grounds that Descartes neglects to demonstrate the possibility of the idea of a most perfect being on which the argument depends. It is possible to mistakenly assume that an idea is possible, when in reality it is contradictory. Leibniz gives the example of a wheel turning at the fastest possible rate. It might at first seem that this idea is legitimate, but if a spoke of the wheel were extended beyond the rim, the end of the spoke would move faster than a nail in the rim itself, revealing a contradiction in the original notion.

For Leibniz, there are two ways of establishing the possibility of an idea: by experience (a posteriori) and by reducing concepts via analysis down to a relation of identity (a priori). Leibniz credits mathematicians and geometers with pushing the practice of demonstrating what would otherwise normally be taken for granted the furthest. For example, in Meditations on Knowledge, Truth, and Ideas, Leibniz writes, That brilliant genius Pascal agrees entirely with these principles when he says, in his famous dissertation on the geometrical spirit [] that it is the task of the geometer to define all terms though ever so little obscure and to prove all truths though little doubtful (L, 294). Leibniz credits his own doctrine of the possibility of ideas with clarifying exactly what it means for something to be beyond doubt and obscurity.

Leibniz describes the result of the reduction of concepts to identity variously as follows: when the thing is resolved into simple primitive notions understood in themselves (L, 231); when every ingredient that enters into a distinct concept is itself known distinctly; when analysis is carried through to the end (L, 292). Since, for Leibniz, all true ideas can be reduced to simple identities, it is, in principle, possible to derive all truths via a movement of synthesis from such simple identities in the way that mathematicians produce systems of knowledge on the basis of their basic definitions and axioms. This kind of a priori knowledge of the world is restricted to God, however. According to Leibniz, it is only possible for our finite minds to have this kind of knowledge which Leibniz calls intuitive or adequate in the case of things which do not depend on experience, or what Leibniz also calls truths of reason, which include abstract logical and metaphysical truths, and mathematical propositions. In the case of truths of fact, by contrast, with the exception of immediately graspable facts of experience, such as, I think, and Various things are thought by me, we are restricted to formulating hypotheses to explain the phenomena of sensory experience, and such knowledge of the world can, for us, only ever achieve the status of hypothesis, though our hypothetical knowledge can be continually improved and refined. (See Section 5, c, below for a discussion of hypotheses in Leibniz.)

Leibniz is in line with his rationalist predecessors in emphasizing the importance of proper order in philosophizing. Leibnizs emphasis on establishing the possibility of ideas prior to using them in demonstrating propositions could be understood as a refinement of the geometrical order that Descartes established over against the order of subject-matter. Leibniz emphasizes order in another connection vis--vis Locke. As Leibniz makes clear in his New Essays, one of the clearest points of disagreement between him and Locke is on the question of innate ideas. In preliminary comments that Leibniz drew up upon first reading Lockes Essay, and which he sent to Locke via Burnett, Leibniz makes the following point regarding philosophical order:

Concerning the question whether there are ideas and truths born with us, I do not find it absolutely necessary for the beginnings, nor for the practice of the art of thinking, to answer it; whether they all come to us from outside, or they come from within us, we will reason correctly provided that we keep in mind what I said above, and that we proceed with order and without prejudice. The question of the origin of our ideas and of our maxims is not preliminary in philosophy, and it is necessary to have made great progress in order to resolve it. (Philosophische Schriften, vol. 5, pp. 15-16)

Leibnizs allusion to what he said above refers to remarks regarding the establishment of the possibility of ideas via experience and the principle of identity. This passage makes it clear that, from Leibnizs point of view, the order in which Locke philosophizes is quite misguided, since Locke begins with a question that should only be addressed after great progress has already been made, particularly with respect to the criteria for distinguishing between true and false ideas, and for establishing legitimate philosophical principles. Empiricists generally put much less emphasis on the order of philosophizing, since they do not aim to reason from first principles grasped a priori.

A fundamental tenet of rationalism perhaps the fundamental tenet is that the world is intelligible. The intelligibility tenet means that everything that happens in the
world happens in an orderly, lawful, rational manner, and that the mind, in principle, if not always in practice, is able to reproduce the interconnections of things in thought provided that it adheres to certain rules of right reasoning. The intelligibility of the world is sometimes couched in terms of a denial of brute facts, where a brute fact is something that just is the case, that is, something that obtains without any reason or explanation (even in principle). Many of the a priori principles associated with rationalism can be understood either as versions or implications of the principle of intelligibility. As such, the principle of intelligibility functions as a basic principle of rationalism. It appears under various guises in the great rationalist systems and is used to generate contrasting philosophical systems. Indeed, one of the chief criticisms of rationalism is the fact that its principles can consistently be used to generate contradictory conclusions and systems of thought. The clearest and best known statement of the intelligibility of the world is Leibnizs principle of sufficient reason. Some scholars have recently emphasized this principle as the key to understanding rationalism (see Della Rocca 2008, chapter 1).

The intelligibility principle raises some classic philosophical problems. Chief among these is a problem of question-begging or circularity. The task of proving that the world is intelligible seems to have to rely on some of the very principles of reasoning in question. In the 17th century, discussion of this fundamental problem centered around the so-called Cartesian circle. The problem is still debated by scholars of 17th century thought today. The viability of the rationalist enterprise seems to depend, at least in part, on a satisfactory answer to this problem.

The most important rational principle in Descartes philosophy, the principle which does a great deal of the work in generating its details, is the principle according to which whatever is clearly and distinctly perceived to be true is true. This principle means that if we can form any clear and distinct ideas, then we will be able to trust that they accurately represent their objects, and give us certain knowledge of reality. Descartes clear and distinct ideas doctrine is central to his conception of the worlds intelligibility, and indeed, it is central to the rationalists conception of the worlds intelligibility more broadly. Although Spinoza and Leibniz both work to refine understanding of what it is to have clear and distinct ideas, they both subscribe to the view that the mind, when directed properly, is able to accurately represent certain basic features of reality, such as the nature of substance.

For Descartes, it cannot be taken for granted from the outset that what we clearly and distinctly perceive to be true is in fact true. It is possible to entertain the doubt that an all-powerful deceiving being fashioned the mind so that it is deceived even in those things it perceives clearly and distinctly. Nevertheless, it is only possible to entertain this doubt when we are not having clear and distinct perceptions. When we are perceiving things clearly and distinctly, their truth is undeniable. Moreover, we can use our capacity for clear and distinct perceptions to demonstrate that the mind was not fashioned by an all-powerful deceiving being, but rather by an all-powerful benevolent being who would not fashion us so as to be deceived even when using our minds properly. Having proved the existence of an all-powerful benevolent being qua creator of our minds, we can no longer entertain any doubts regarding our clear and distinct ideas even when we are not presently engaged in clear and distinct perceptions.

Descartes legitimation of clear and distinct perception via his proof of a benevolent God raises notorious interpretive challenges. Scholars disagree about how to resolve the problem of the Cartesian circle. However, there is general consensus that Descartes procedure is not, in fact, guilty of vicious, logical circularity. In order for Descartes procedure to avoid circularity, it is generally agreed that in some sense clear and distinct ideas need already to be legitimate before the proof of Gods existence. It is only in another sense that Gods existence legitimates their truth. Scholars disagree on how exactly to understand those different senses, but they generally agree that there is some sense at least in which clear and distinct ideas are self-legitimating, or, otherwise, not in need of legitimation.

That some ideas provide a basic standard of truth is a fundamental tenet of rationalism, and undergirds all the other rationalist principles at work in the construction of rationalist systems of philosophy. For the rationalists, if it cannot be taken for granted in at least some sense from the outset that the mind is capable of discerning the difference between truth and falsehood, then one never gets beyond skepticism.

The Continental rationalists deploy the principle of intelligibility and subordinate rational principles derived from it in generating much of the content of their respective philosophical systems. In no aspect of their systems is the application of rational principles to the generation of philosophical content more evident and more clearly illustrative of contrasting interpretations of these principles than in that for which the Continental rationalists are arguably best known: substance metaphysics.

Descartes deploys his clear and distinct ideas doctrine in justifying his most well-known metaphysical position: substance dualism. The first step in Descartes demonstration of mind-body dualism, or, in his terminology, of a real distinction (that is, a distinction between two substances) between mind and body is to show that while it is possible to doubt that one has a body, it is not possible to doubt that one is thinking. As Descartes makes clear in the Principles of Philosophy, one of the chief upshots of his famous cogito argument is the discovery of the distinction between a thinking thing and a corporeal thing. The impossibility of doubting ones existence is not the impossibility of doubting that one is a human being with a body with arms and legs and a head. It is the impossibility of doubting, rather, that one doubts, perceives, dreams, imagines, understands, wills, denies, and other modalities that Descartes attributes to the thinking thing. It is possible to think of oneself as a thing that thinks, and to recognize that it is impossible to doubt that one thinks, while continuing to doubt that one has a body with arms and legs and a head. So, the cogito drives a preliminary wedge between mind and body.

At this stage of the argument, however, Descartes has simply established that it is possible to conceive of himself as a thinking thing without conceiving of himself as a corporeal thing. It remains possible that, in fact, the thinking thing is identical with a corporeal thing, in other words, that thought is somehow something a body can do; Descartes has yet to establish that the epistemological distinction between his knowledge of his mind and his knowledge of body that results from the hyperbolic doubt translates to a metaphysical or ontological distinction between mind and body. The move from the epistemological distinction to the ontological distinction proceeds via the doctrine of clear and distinct ideas. Having established that whatever he clearly and distinctly perceives is true, Descartes is in a position to affirm the real distinction between mind and body.

In this life, it is never possible to clearly and distinctly perceive a mind actuall
y separate from a body, at least in the case of finite, created minds, because minds and bodies are intimately unified in the composite human being. So Descartes cannot base his proof for the real distinction of mind and body on the clear and distinct perception that mind and body are in fact independently existing things. Rather, Descartes argument is based on the joint claims that (1) it is possible to have a clear and distinct idea of thought apart from extension and vice versa; and (2) whatever we can clearly and distinctly understand is capable of being created by God exactly as we clearly and distinctly understand it. Thus, the fact that we can clearly and distinctly understand thought apart from extension and vice versa entails that thinking things and extended things are really distinct (in the sense that they are distinct substances separable by God).

The foregoing argument relies on certain background assumptions which it is now necessary to explain, in particular, Descartes conception of substance. In the Principles, Descartes defines substance as a thing which exists in such a way as to depend on no other thing for its existence (CSM I, 210). Properly speaking, only God can be understood to depend on no other thing, and so only God is a substance in the absolute sense. Nevertheless, Descartes allows that, in a relative sense, created things can count as substances too. A created thing is a substance if the only thing it relies upon for its existence is the ordinary concurrence of God (ibid.). Only mind and body qualify as substances in this secondary sense. Everything else is a modification or property of minds and bodies. A second point is that, for Descartes, we do not have a direct knowledge of substance; rather, we come to know substance by virtue of its attributes. Thought and extension are the attributes or properties in virtue of which we come to know thinking and corporeal substance, or mind and body. This point relies on the application of a key rational principle, to wit, nothingness has no properties. For Descartes, there cannot simply be the properties of thinking and extension without these properties having something in which to inhere. Thinking and extension are not just any properties; Descartes calls them principal attributes because they constitute the nature of their respective substances. Other, non-essential properties, cannot be understood without the principal attribute, but the principal attribute can be understood without any of the non-essential properties. For example, motion cannot be understood without extension, but extension can be understood without motion.

Descartes conception of mind and body as distinct substances includes some interesting corollaries which result from a characteristic application of rational principles and account for some characteristic doctrinal differences between Descartes and empiricist philosophers. One consequence of Descartes conception of the mind as a substance whose principal attribute is thought is that the mind must always be thinking. Since, for Descartes, thinking is something of which the thinker is necessarily aware, Descartes commitment to thought as an essential, and therefore, inseparable, property of the mind raises some awkward difficulties. Arnauld, for example, raises one such difficulty in his Objections to Descartes Meditations: presumably there is much going on in the mind of an infant in its mothers womb of which the infant is not aware. In response to this objection, and also in response to another obvious problem, that is, that of dreamless sleep, Descartes insists on a distinction between being aware of or conscious of our thoughts at the time we are thinking them, and remembering them afterwards (CSMK III, 357). The infant is, in fact, aware of its thinking in the mothers womb, but it is aware only of very confused sensory thoughts of pain and pleasure and heat (not, as Descartes points out, metaphysical matters (CSMK III, 189)) which it does not remember afterwards. Similarly, the mind is always thinking even in the most dreamless sleep, it is just that the mind often immediately forgets much of what it had been aware.

Descartes commitment to embracing the implications however counter-intuitive of his substance-attribute metaphysics, puts him at odds with, for instance, Locke, who mocks the Cartesian doctrine of the always-thinking soul in his An Essay Concerning Human Understanding. For Locke, the question whether the soul is always thinking or not must be decided by experience and not, as Locke says, merely by hypothesis (An Essay Concerning Human Understanding, Book II, Chapter 1). The evidence of dreamless sleep makes it obvious, for Locke, that the soul is not always thinking. Because Locke ties personal identity to memory, if the soul were to think while asleep without knowing it, the sleeping man and the waking man would be two different persons.

Descartes commitment to the always-thinking mind is a consequence of his commitment to a more basic rational principle. In establishing his conception of thinking substance, Descartes reasons from the attribute of thinking to the substance of thinking on the grounds that nothing has no properties. In this case, he reasons in the other direction, from the substance of thinking, that is, the mind, to the property of thinking on the converse grounds that something must have properties, and the properties it must have are the properties that make it what it is; in the case of the mind, that property is thought. (Leibniz found a way to maintain the integrity of the rational principle without contradicting experience: admit that thinking need not be conscious. This way the mind can still think in a dreamless sleep, and so avoid being without any properties, without any problem about the recollection of awareness.)

Another consequence of Descartes substance metaphysics concerns corporeal substance. For Descartes, we do not know corporeal substance directly, but rather through a grasp of its principal attribute, extension. Extension qua property requires a substance in which to inhere because of the rational principle, nothing has no properties. This rational principle leads to another characteristic Cartesian position regarding the material world: the denial of a vacuum. Descartes denies that space can be empty or void. Space has the property of being extended in length, breadth, and depth, and such properties require a substance in which to inhere. Thus, nothing, that is, a void or vacuum, is not able to have such properties because of the rational principle, nothing has no properties. This means that all space is filled with substance, even if it is imperceptible. Once again, Descartes answers a debated philosophical question on the basis of a rational principle.

If Descartes is known for his dualism, Spinoza, of course, is known for monism the doctrine that there is only one substance. Spinozas argument for substance monism (laid out in the first fifteen propositions of the Ethics) has no essential basis in sensory experience; it proceeds through rational argumentation and the deployment of rational principles; although Spinoza provides one a posteriori argument for Gods existence, he makes clear that he presents it only because it is easier to grasp than the a priori arguments, and not because it is in any way necessary.

The crucial step in the argument for substance monism comes in Ethics 1p5: In Nature there cannot be two or more substances of the same nature or attribute. It is at this proposition that Descartes (and Leibniz, and many others) would part ways with Spinoza. The most striking and controversial implication of this propositio
n, at least from a Cartesian perspective, is that human minds cannot qualify as substances, since human minds all share the same nature or attribute, that is, thought. In Spinozas philosophy, human minds are actually themselves properties Spinoza calls them modes of a more basic, infinite substance.

The argument for 1p5 works as follows. If there were two or more distinct substances, there would have to be some way to distinguish between them. There are two possible distinctions to be made: either by a difference in their affections or by a difference in their attributes. For Spinoza, a substance is something which exists in itself and can be conceived through itself; an attribute is what the intellect perceives of a substance, as constituting its essence (Ethics 1d4). Spinozas conception of attributes is a matter of longstanding scholarly debate, but for present purposes, we can think of it along Cartesian lines. For Descartes, substance is always grasped through a principal property, which is the nature or essence of the substance. Spinoza agrees that an attribute is that through which the mind conceives the nature or essence of substance. With this in mind, if a distinction between two substances were to be made on the basis of a difference in attributes, then there would not be two substances of the same attribute as the proposition indicates. This means that if there were two substances of the same attribute, it would be necessary to distinguish between them on the basis of a difference in modes or affections.

Spinoza conceives of an affection or mode as something which exists in another and needs to be conceived through another. Given this conception of affections, it is impossible, for Spinoza, to distinguish between two substances on the basis of a difference in affections. Doing so would be somewhat akin to affirming that there are two apples on the basis of a difference between two colors, when one apple can quite possibly have a red part and a green part. As color differences do not per se determine differences between apples, in a similar way, modal differences cannot determine a difference between substances you could just be dealing with one substance bearing multiple different affections. It is notable that in 1p5, Spinoza uses virtually the same substance-attribute schema as Descartes to deny a fundamental feature of Descartes system.

Having established 1p5, the next major step in Spinozas argument for substance monism is to establish the necessary existence and infinity of substance. For Spinoza, if things have nothing in common with each other, one cannot be the cause of the other. This thesis depends upon assumptions that lie at the heart of Spinozas rationalism. Something that has nothing in common with another thing cannot be the cause of the other thing because things that have nothing in common with one another cannot be understood through one another (Ethics 1a5). But, for Spinoza, effects should be able to be understood through causes. Indeed, what it is to understand something, for Spinoza, is to understand its cause. The order of knowledge, provided that the knowledge is genuine, or, as Spinoza says, adequate, must map onto the order of being, and vice versa. Thus, Spinozas claim that if things have nothing in common with one another, one cannot be the cause of the other, is an expression of Spinozas fundamental, rationalist commitment to the intelligibility of the world. Given this assumption, and given the fact that no two substances have anything in common with one another, since no two substances share the same nature or attribute, it follows that if a substance is to exist, it must exist as causa sui (self-caused); in other words, it must pertain to the essence of substance to exist. Moreover, Spinoza thinks that since there is nothing that has anything in common with a given substance, there is therefore nothing to limit the nature of a given substance, and so every substance will necessarily be infinite. This assertion depends on another deep-seated assumption of Spinozas philosophy: nothing limits itself, but everything by virtue of its very nature affirms its own nature and existence as much as possible.

At this stage, Spinoza has argued that substances of a single attribute exist necessarily and are necessarily infinite. The last major stage of the argument for substance monism is the transition from multiple substances of a single attribute to only one substance of infinite attributes. Scholars have expressed varying degrees of satisfaction with the lucidity of this transition. It seems to work as follows. It is possible to attribute many attributes to one substance. The more reality or being each thing has, the more attributes belong to it. Therefore, an absolutely infinite being is a being that consists of infinite attributes. Spinoza calls an absolutely infinite being or substance consisting of infinite attributes God. Spinoza gives four distinct arguments for Gods existence in Ethics 1p11. The first is commonly interpreted as Spinozas version of an ontological argument. It refers back to 1p7 where Spinoza proved that it pertains to the essence of substance to exist. The second argument is relevant to present purposes, since it turns on Spinozas version of the principle of sufficient reason: For each thing there must be assigned a cause, or reason, both for its existence and for its nonexistence (Ethics 1p11dem). But there can be no reason for Gods nonexistence for the same reasons that all substances are necessarily infinite: there is nothing outside of God that is able to limit Him, and nothing limits itself. Once again, Spinozas argument rests upon his assumption that things by nature affirm their own existence. The third argument is a posteriori, and the fourth pivots like the second on the assumption that things by nature affirm their own existence.

Having proven that a being consisting of infinite attributes exists, Spinozas argument for substance monism is nearly complete. It remains only to point out that no substance besides God can exist, because if it did, it would have to share at least one of Gods infinite attributes, which, by 1p5, is impossible. Everything that exists, then, is either an attribute or an affection of God.

Leibnizs universe consists of an infinity of monads or simple substances, and God. For Leibniz, the universe must be composed of monads or simple substances. His justification for this claim is relatively straightforward. There must be simples, because there are compounds, and compounds are just collections of simples. To be simple, for Leibniz, means to be without parts, and thus to be indivisible. For Leibniz, the simples or monads are the true atoms of nature (L, 643). However, material atoms are contrary to reason (L, 456). Manifold a priori considerations lead Leibniz to reject material atoms. In the first place, the notion of a material atom is contradictory in Leibnizs view. Matter is extended, and that which is extended is divisible into parts. The very notion of an atom, however, is the notion of something indivisible, lacking parts.

From a different perspective, Leibnizs dynamical investigations provide another argument against material atoms. Absolute rigidity is included in the notion of a material atom, since any elasticity in the atom could only be accounted for on the basis of parts within the atom shifting their position with respect to each other, which is contrary to the notion of a partless atom. According to Leibnizs analysis of impact, however, absolute rigidity is shown not to make sense. Consider the rebound of one atom as a result of its collision with another. If the atoms were absol
utely rigid, the change in motion resulting from the collision would have to happen instantaneously, or, as Leibniz says, through a leap or in a moment (L, 446). The atom would change from initial motion to rest to rebounded motion without passing through any intermediary degrees of motion. Since the body must pass through all the intermediary degrees of motion in transitioning from one state of motion to another, it must not be absolutely rigid, but rather elastic; the analysis of the parts of the body must, in correlation with the degree of motion, proceed to infinity. Leibnizs dynamical argument against material atoms turns on what he calls the law of continuity, an a priori principle according to which no change occurs through a leap.

The true unities, or true atoms of nature, therefore, cannot be material; they must be spiritual or metaphysical substances akin to souls. Since Leibnizs spiritual substances, or monads, are absolutely simple, without parts, they admit neither of dissolution nor composition. Moreover, there can be no interaction between monads, monads cannot receive impressions or undergo alterations by means of being affected from the outside, since, in Leibnizs famous phrase from the Monadology, monads have no windows (L, 643). Monads must, however, have qualities, otherwise there would be no way to explain the changes we see in things and the diversity of nature. Indeed, following from Leibnizs principle of the identity of indiscernibles, no two monads can be exactly alike, since each monad stands in a unique relation to the rest, and, for Leibniz, each monads relation to the rest is a distinctive feature of its nature. The way in which, for Leibniz, monads can have qualities while remaining simple, or in other words, the only way there can be multitude in simplicity is if monads are characterized and distinguished by means of their perceptions. Leibnizs universe, in summary, consists in monads, simple spiritual substances, characterized and distinguished from one another by a unique series of perceptions determined by each monads unique relationship vis--vis the others.

Of the great rationalists, Leibniz is the most explicit about the principles of reasoning that govern his thought. Leibniz singles out two, in particular, as the most fundamental rational principles of his philosophy: the principle of contradiction and the principle of sufficient reason. According to the principle of contradiction, whatever involves a contradiction is false. According to the principle of sufficient reason, there is no fact or true proposition without there being a sufficient reason for its being so and not otherwise (L, 646). Corresponding to these two principles of reasoning are two kinds of truths: truths of reasoning and truths of fact. For Leibniz, truths of reasoning are necessary, and their opposite is impossible. Truths of fact, by contrast, are contingent, and their opposite is possible. Truths of reasoning are by most commentators associated with the principle of contradiction because they can be reduced via analysis to a relation between two primitive ideas, whose identity is intuitively evident. Thus, it is possible to grasp why it is impossible for truths of reasoning to be otherwise. However, this kind of resolution is only possible in the case of abstract propositions, such as the propositions of mathematics (see Section 3, c, above). Contingent truths, or truths of fact, by contrast, such as Caesar crossed the Rubicon, to use the example Leibniz gives in the Discourse on Metaphysics, are infinitely complicated. Although, for Leibniz, every predicate is contained in its subject, to reduce the relationship between Caesars notion and his action of crossing the Rubicon would require an infinite analysis impossible for finite minds. Caesar crossed the Rubicon is a contingent proposition, because there is another possible world in which Caesar did not cross the Rubicon. To understand the reason for Caesars crossing, then, entails understanding why this world exists rather than any other possible world. It is for this reason that contingent truths are associated with the principle of sufficient reason. Although the opposite of truths of fact is possible, there is nevertheless a sufficient reason why the fact is so and not otherwise, even though this reason cannot be known by finite minds.

Truths of fact, then, need to be explained; there must be a sufficient reason for them. However, according to Leibniz, a sufficient reason for existence cannot be found merely in any one individual thing or even in the whole aggregate and series of things (L, 486). That is to say, the sufficient reason for any given contingent fact cannot be found within the world of which it is a part. The sufficient reason must explain why this world exists rather than another possible world, and this reason must lie outside the world itself. For Leibniz, the ultimate reason for things must be contained in a necessary substance that creates the world, that is, God. But if the existence of God is to ground the series of contingent facts that make up the world, there must be a sufficient reason why God created this world rather than any of the other infinite possible worlds contained in his understanding. As a perfect being, God would only have chosen to bring this world into existence rather than any other because it is the best of all possible worlds. Gods choice, therefore, is governed by the principle of fitness, or what Leibniz also calls the principle of the best (L, 647). The best world, according to Leibniz, is the one which maximizes perfection; and the most perfect world is the one which balances the greatest possible variety with the greatest possible order. God achieves maximal perfection in the world through what Leibniz calls the pre-established harmony. Although the world is made up of an infinity of monads with no direct interaction with one another, God harmonizes the perceptions of each monad with the perceptions of every other monad, such that each monad represents a unique perspective on the rest of the universe according to its position vis--vis the others.

According to Leibnizs philosophy, in the case of all true propositions, the predicate is contained in the subject. This is often known as the predicate-in-notion principle. The relationship between predicate and subject can only be reduced to an identity relation in the case of truths of reason, whereas in the case of truths of fact, the reduction requires an infinite analysis. Nevertheless, in both cases, it is possible in principle (which is to say, for an infinite intellect) to know everything that will ever happen to an individual substance, and even everything that will happen in the world of an individual substance on the basis of an examination of the individual substances notion, since each substance is an expression of the entire world. Leibnizs predicate-in-notion principle therefore unifies both of his two great principles of reasoning the principle of contradiction and the principle of sufficient reason since the relation between predicate and subject is either such that it is impossible for it to be otherwise or such that there is a sufficient reason why it is as it is and not otherwise. Moreover, it represents a particularly robust expression of the principle of intelligibility at the very heart of Leibnizs system. There is a reason why everything is as it is, whether that reason is subject to finite or only to infinite analysis.

(See also: 17th Century Theories of Substance.)

Rationalism is often criticized for placing too much confidence in the ability of reason alone to know the world. The extent to which one finds t
his criticism justified depends largely on ones view of reason. For Hume, for instance, knowledge of the world of matters of fact is gained exclusively through experience; reason is merely a faculty for comparing ideas gained through experience; it is thus parasitic upon experience, and has no claim whatsoever to grasp anything about the world itself, let alone any special claim. For Kant, reason is a mental faculty with an inherent tendency to transgress the bounds of possible experience in an effort to grasp the metaphysical foundations of the phenomenal realm. Since knowledge of the world is limited to objects of possible experience, for Kant, reason, with its delusions of grasping reality beyond those limits, must be subject to critique.

Sometimes rationalism is charged with neglecting or undervaluing experience, and with embarrassingly having no means of accounting for the tremendous success of the experimental sciences. While the criticism of the confidence placed in reason may be defensible given a certain conception of reason (which may or may not itself be ultimately defensible), the latter charge of neglecting experience is not; more often than not it is the product of a false caricature of rationalism

Descartes and Leibniz were the leading mathematicians of their day, and stood at the forefront of science. While Spinoza distinguished himself more as a political thinker, and as an interpreter of scripture (albeit a notorious one) than as a mathematician, Spinoza too performed experiments, kept abreast of the leading science of the day, and was renowned as an expert craftsman of lenses. Far from neglecting experience, the great rationalists had, in general, a sophisticated understanding of the role of experience and, indeed, of experiment, in the acquisition and development of knowledge. The fact that the rationalists held that experience and experiment cannot serve as foundations for knowledge, but must be fitted within, and interpreted in light of, a rational epistemic framework, should not be confused with a neglect of experience and experiment.

One of the stated purposes of Descartes Meditations, and, in particular, the hyperbolic doubts with which it commences, is to reveal to the mind of the reader the limitations of its reliance on the senses, which Descartes regards as an inadequate foundation for knowledge. By leading the mind away from the senses, which often deceive, and which yield only confused ideas, Descartes prepares the reader to discover the clear and distinct perceptions of the pure intellect, which provide a proper foundation for genuine knowledge. Nevertheless, empirical observations and experimentation clearly had an important role to play in Descartes natural philosophy, as evidenced by his own private empirical and experimental research, especially in optics and anatomy, and by his explicit statements in several writings on the role and importance of observation and experiment.

In Part 6 of the Discourse on the Method, Descartes makes an open plea for assistance both financial and otherwise in making systematic empirical observations and conducting experiments. Also in Discourse Part 6, Descartes lays out his program for developing knowledge of nature. It begins with the discovery of certain seeds of truth implanted naturally in our souls (CSM I, 144). From them, Descartes seeks to derive the first principles and causes of everything. Descartes Meditations illustrates these first stages of the program. By seeds of truth Descartes has in mind certain intuitions, including the ideas of thinking, and extension, and, in particular, of God. On the basis of clearly and distinctly perceiving the distinction between what belongs properly to extension (figure, position, motion) and what does not (colors, sounds, smells, and so forth), Descartes discovers the principles of physics, including the laws of motion. From these principles, it is possible to deduce many particular ways in which the details of the world might be, only a small fraction of which represent the way the world actually is. It is as a result of the distance, as it were, between physical principles and laws of nature, on one hand, and the particular details of the world, on the other, that, for Descartes, observations and experiments become necessary.

Descartes is ambivalent about the relationship between physical principles and particulars, and about the role that observation and experiment play in mediating this relationship. On the one hand, Descartes expresses commitment to the ideal of a science deduced with certainty from intuitively grasped first principles. Because of the great variety of mutually incompatible consequences that can be derived from physical principles, observation and experiment are required even in the ideal deductive science to discriminate between actual consequences and merely possible ones. According to the ideal of deductive science, however, observation and experiment should be used only to facilitate the deduction of effects from first causes, and not as a basis for an inference to possible explanations of natural phenomena, as Descartes makes clear at one point his Principles of Philosophy (CSM I, 249). If the explanations were only possible, or hypothetical, the science could not lay claim to certainty per the deductive ideal, but merely to probability.

On the other hand, Descartes states explicitly at another point in the Principles of Philosophy that the explanations provided of such phenomena as the motion of celestial bodies and the nature of the earths elements should be regarded merely as hypotheses arrived at on the basis of a posteriori reasoning (CSM I, 255); while Descartes says that such hypotheses must agree with observation and facilitate predictions, they need not in fact reflect the actual causes of phenomena. Descartes appears to concede, albeit reluctantly, that when it comes to explaining particular phenomena, hypothetical explanations and moral certainty (that is, mere probability) are all that can be hoped for.

Scholars have offered a range of explanations for the inconsistency in Descartes writings on the question of the relation between first principles and particulars. It has been suggested that the inconsistency within the Principles of Philosophy reflects different stages of its composition (see Garber 1978). However the inconsistency might be explained, it is clear that Descartes did not take it for granted that the ideal of a deductive science of nature could be realized. Moreover, whether or not Descartes ultimately believed the ideal of deductive science was realizable, he was unambiguous on the importance of observation and experiment in bridging the distance between physical principles and particular phenomena. (For further discussion, see Ren Descartes: Scientific Method.)

The one work that Spinoza published under his own name in his lifetime was his geometrical reworking of Descartes Principles of Philosophy. In Spinozas presentation of the opening sections of Part 3 of Descartes Principles, Spinoza puts a strong emphasis on the hypothetical nature of the explanations of natural phenomena in Part 3. Given the hesitance and ambivalence with which Descartes concedes the hypothetical nature of his explanations in his Principles, Spinozas unequivocal insistence on hypotheses is striking. Elsewhere Spinoza endorses hypotheses more directly. In the Treatise on the Emendation of the Intellect, Spinoza describes forming the concept of a sphere by affirming the rotation of a semicircle in thought. He points out that this idea is a true idea of a sphere even if no sphere has ever been produced this way in nature (The Colle
cted Works of Spinoza, Vol. 1, p. 32). Spinozas view of hypotheses relates to his conception of good definitions (see Section 3, b, above). If the cause through which one conceives something allows for the deduction of all possible effects, then the cause is an adequate one, and there is no need to fear a false hypothesis. Spinoza appears to differ from Descartes in thinking that the formation of hypotheses, if done properly, is consistent with deductive certainty, and not tantamount to mere probability or moral certainty.

Again in the Treatise on the Emendation of the Intellect, Spinoza speaks in Baconian fashion of identifying aids that can assist in the use of the senses and in conducting orderly experiments. Unfortunately, Spinozas comments regarding aids are very unclear. This is perhaps explained by the fact that they appear in a work that Spinoza never finished. Nevertheless, it does seem clear that although Spinoza, like Descartes, emphasized the importance of discovering proper principles from which to deduce knowledge of everything else, he was no less aware than Descartes of the need to proceed via observation and experiment in descending from such principles to particulars. At the same time, given his analysis of the inadequacy of sensory images, the collection of empirical data must be governed by rules and rational guidelines the details of which it does not seem that Spinoza ever worked out.

A valuable perspective on Spinozas attitude toward experimentation is provided by Letter 6, which Spinoza wrote to Oldenburg with comments on Robert Boyles experimental research. Among other matters, at issue is Boyles redintegration (or reconstitution) of niter (potassium nitrate). By heating niter with a burning coal, Boyle separated the niter into a fixed part and a volatile part; he then proceeded to distill the volatile part, and recombine it with the fixed part, thereby redintegrating the niter. Boyles aim was to show that the nature of niter is not determined by a Scholastic substantial form, but rather by the composition of parts, whose secondary qualities (color, taste, smell, and so forth) are determined by primary qualities (size, position, motion, and so forth). While taking no issue with Boyles attempt to undermine the Scholastic analysis of physical natures, Spinoza criticized Boyles interpretation of the experiment, arguing that the fixed niter was merely an impurity left over, and that there was no difference between the niter and the volatile part other than a difference of state.

Two things stand out from Spinozas comments on Boyle. On the one hand, Spinoza exhibits a degree of impatience with Boyles experiments, charging some of them with superfluity on the grounds either that what they show is evident on the basis of reason alone, or that previous philosophers have already sufficiently demonstrated them experimentally. In addition, Spinozas own interpretation of Boyles experiment is primarily based in a rather speculative, Cartesian account of the mechanical constitution of niter (as Boyle himself points out in response to Spinoza). On the other hand, Spinoza appears eager to show his own fluency with experimental practice, describing no fewer than three different experiments of his own invention to support his interpretation of the redintegration. What Spinoza is critical of is not so much Boyles use of experiment per se as his relative neglect of relevant rational considerations. For instance, Spinoza at one point criticizes Boyle for trying to show that secondary qualities depend on primary qualities on experimental grounds. Spinoza thought the proposition needed to be demonstrated on rational grounds. While Spinoza acknowledges the importance and necessity of observation and experiment, his emphasis and focus is on the rational framework needed for making sense of experimental findings, without which the results are confused and misleading.

In principle, Leibniz thinks it is not impossible to discover the interior constitution of bodies a priori on the basis of a knowledge of God and the principle of the best according to which He creates the world. Leibniz sometimes remarks that angels could explain to us the intelligible causes through which all things come about, but he seems conflicted over whether such understanding is actually possible for human beings. Leibniz seems to think that while the a priori pathway should be pursued in this life by the brightest minds in any case, its perfection will only be possible in the afterlife. The obstacle to an a priori conception of things is the complexity of sensible effects. In this life, then, knowledge of nature cannot be purely a priori, but depends on observation and experimentation in conjunction with reason

Apart from perception, we have clear and distinct ideas only of magnitude, figure, motion, and other such quantifiable attributes (primary qualities). The goal of all empirical research must be to resolve phenomena (including secondary qualities) into such distinctly perceived, quantifiable notions. For example, heat is explained in terms of some particular motion of air or some other fluid. Only in this way can the epistemic ideal be achieved of understanding how phenomena follow from their causes in the same way that we know how the hammer stroke after a period of time follows from the workings of a clock (L, 173). To this end, experiments must be carried out to indicate possible relationships between secondary qualities and primary qualities, and to provide a basis for the formulation of hypotheses to explain the phenomena.

Nevertheless, there is an inherent limitation to this procedure. Leibniz explains that if there were people who had no direct experience of heat, for instance, even if someone were to explain to them the precise mechanical cause of heat, they would still not be able to know the sensation of heat, because they would still not distinctly grasp the connection between bodily motion and perception (L, 285). Leibniz seems to think that human beings will never be able to bridge the explanatory gap between sensations and mechanical causes. There will always be an irreducibly confused aspect of sensible ideas, even if they can be associated with a high degree of sophistication with distinctly perceivable, quantifiable notions. However, this limitation does not mean, for Leibniz, that there is any futility in human efforts to understand the world scientifically. In the first place, experimental knowledge of the composition of things is tremendously useful in practice, even if the composition is not distinctly perceived in all its parts. As Leibniz points out, the architect who uses stones to erect a cathedral need not possess a distinct knowledge of the bits of earth interposed between the stones (L, 175). Secondly, even if our understanding of the causes of sensible effects must remain forever hypothetical, the hypotheses themselves can be more or less refined, and it is proper experimentation that assists in their refinement.

When citing the works of Descartes, the three volume English translation by Cottingham, Stoothoff, Murdoch, and Kenny was used. For the original language, the edition by Adam and Tannery was consulted.

When citing Spinozas Ethics, the translation by Curley in A Spinoza Reader was used. The following system of abbreviation was used when citing passages from the Ethics: the first number designates the part of the Ethics (1-5); then, p is for proposition, d for definition, a for axiom, dem for demonstration, c for corollary, and s for scholium. So, 1p17s refers to the scholium of the seventeenth proposition of the first part of the Ethics. For the original la
nguage, the edition by Gebhardt was consulted.

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Rationalism | Theopedia

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Rationalism as a philosophy stresses reason as the means of determining truth. Mind is given authority over sense, the w:a priori over the w:a posteriori. Rationalists are usually foundationalists, who affirm that there are first principles of knowledge, without which no knowledge is possible. For a rationalist, reason arbitrates truth, and truth is objective.

Although w:Aristotle (384-322 B.C.) believed that knowledge began in the senses, his stress on reason and logic made him the father of Western rationalism. w:Ren Descartes (1596-1650), w:Benedict Spinoza (1632-1677), and w:Gottfried Leibniz (1646-1716) were the chief modern rationalists.^[1]^ ^ [2]^ ^[3]^

Most worldviews have at least one major rationalist proponent. Leibniz embraced theism.^[4]^ Spinoza held to pantheism.^[5]^ w:Ayn Rand (1905-1977) professed atheism.^[6]^ Most deists held some form of rationalism. Even pantheism is represented by strong rationalistic proponents, such as w:Charles Hartshorne (1897-2000).^ [7]^ Finite godism has been rationally defended by w:John Stuart Mill (1806-1873) and others.^[8]^

The reason that various worldviews all have forms of rationalism is that rationalism is an epistemology, whereas a worldview is an aspect of metaphysics. Rationalism is a means of discerning truth, and most worldviews have exponents who use it to determine and defend truth as they see it.^[9]^

Some ideas are common to virtually all rationalists. These include the following factors, even though some rationlists defend them, modify them, or limit them in ways others do not.

Some rationalists downplay, if not negate, any determinative role of the senses in the knowing process. They stress the rational exclusively. w:Spinoza is an example of this view. Others combine sense and reason, such as Aquinas and w:Leibniz. The former are more deductive in their approach to learning truth; the latter are more inductive and inferential.

A crucial difference among rationalists is found in the scope of reason. Some rationalists, such as w:Spinoza, give reason an all-encompassing scope. It is the sole means of determining truth. Others, such as Aquinas, believe reason is capable of discovering some truths (i.e. the existence of God), but not all truth (i.e. the Trinity).^[11]^ Those in the latter category believe that there are truths that are in accord with reason and some that go beyond reason. Even the latter are not contrary to reason. They simply are beyond the ability of reason to attain on its own. They can be known only from special revelation.

Rationalism as a whole has both positive and negative dimensions for an apologists. Unlimited rationalism that denies all special revelation, obviously is unacceptable for a theist. Nor is any form of rationalism that denies theism in accord with orthodox Christianity.

However, foundationalism's stress on the need for first principles, is both true and valuable. Also valuable is the belief in objective truth. The rationalist's emphasis on the exclusive nature of truth claims is also a benefit to Christian apologetics.

From a Christian perspective, the rationalist theologian Jonathan Edwards made an important distinction: All truth is given by revelation, either general or special, and it must be received by reason. Reason is the God-given means for discovering the truth that God discloses, whether in his world or his Word. While God wants to reach the heart with truth, he does not bypass the mind along the way.^ [12]^ In this modified sense, there is great value in Christian rationalism.

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Perfusion & Diffusion in Cryonics Protocol – BEN BEST

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by Ben Best CONTENTS: LINKS TO SECTIONS BY TOPIC

Preparing a cryonics patient for cryostorage can involve three distinct stages of alteration of body fluids:

(1) patient cooldown/cardiopulmonary support

(2) blood washout/replacement for patient transport

(3) cryoprotectant perfusion

During patient cooldown/cardiopulmonary support, a cryonics emergency response team or health care personnel may inject a number of medicaments to minimize ischemic injury and facilitate cryopreservation. The first and most important of these medicaments would be heparin, to prevent blood clotting. (For more details on the initial cooldown process, see Emergency Preparedness for a Local Cryonics Group).

Once the patient is cooled, the blood can be washed-out and replaced with a solution intended to keep organs/tissues alive while the patient is being transported to a cryonics facility. At the cryonics facility the organ/tissue preservation solution is replaced with the cryopreservation solution intended to prevent ice formation when the patient is further cooled to temperatures of 120C (glass transition temperature) or 196C (liquid nitrogen temperature) for long-term storage.

For both organ/tissue preservation & cryoprotection it is necessary to replace the fluid contents of blood vessels & tissue cells with other fluids. The process of injecting & circulating fluids through blood vessels is called perfusion. The passive process by which fluids enter & exit both blood vessels & cells is called diffusion.

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Body fluids can be described as solutes dissolved in a solvent, where the solvent is water and the solutes are substances like sodium chloride (NaCl, table salt), glucose or protein. Both water and solute molecules tend to move randomly in fluid with energy and velocity that is directly proportional to temperature. When there is a difference in concentration between water or solute molecules in one area of the fluid compartment compared to the rest of the compartment, random motion of the molecules will eventually result in a uniform distribution of all types of molecules throughout the compartment. In thermodynamics this is termed a decrease in potential energy (Gibbs free energy, not heat energy) due to an increase in entropy at constant temperature leading to equilibrium.

The movement of molecules from an area of high concentration to an area of low concentration is called diffusion. The rate of diffusion (J) can be quantified by Fick's law of diffusion:

dc J = DA---- dx J = rate of diffusion (moles/time) D = Diffusion coefficient A = Area across which diffusion occurs dc/dx = concentration gradient (instantaneous concentration difference divided by instantaneous distance)

Fick's First Law states that the rate of diffusion down a concentration gradient is proportional to the instantaneous magnitude of the concentration gradient (which changes as diffusion proceeds). For movement of molecules from a region of higher concentration to a region of lower concentration dc/dx will be negative, so multiplying by DA gives a positive value to J. Diffusion coefficient is higher for higher temperature and for smaller molecules.

Diffusion can occur not only within a fluid compartment, but across partitions that separate fluid compartments. The relevant partitions for animals are cell membranes and capillary walls. Cell membranes are lipid bilayers that allow for free diffusion of lipid soluble substances like oxygen, nitrogen, carbon dioxide and alcohol, while blocking movement of ions and polar molecules. But cell membranes also contain channels made of protein. Protein channels for water allow for very rapid diffusion of water across the membranes. Protein channels for potassium(K+), sodium(Na+) and other ions allow for more restricted diffusion across cell membranes. There is also facilitated diffusion (active transport) of many types of molecules across membranes.

For a normal 70kilogram (154pound) adult the total body fluid is about 60% of the body weight. Almost all of this fluid can be described as extracellular or intracellular (excluding only cerebrospinal fluid, synovial fluid and a few other small fluid compartments). Extracellular fluid can be further subdivided into plasma (noncellular part of blood) and interstitial fluid (fluid between cells that is not in blood vessels). Cell membranes separate intracellular fluid from extracellular fluid, whereas capillary walls separate plasma from interstitial fluid. The relative percentages of these fluids can be summarized as:

Intracellular fluid 67% Extracellular fluid Interstitial fluid 26% Plasma 7%

Note that blood volume includes both plasma & blood cells such that adding the intracellular fluid volume of blood cells to plasma volume makes blood 12% of total body fluid.

Osmosis refers to diffusion of water (solvent) across a membrane that is semi-permeable, ie, permeable to water, but not to all solutes in the solution. If membrane-impermeable solutes are added to one side of the membrane, but not to the other side, water will be less concentrated on the solute side of the membrane. This concentration gradient will cause water to diffuse across the semi-permeable membrane into the side with the solutes unless pressure is applied to prevent the diffusion of water. The amount of pressure required to prevent any diffusion of water across the semi-permeable membrane is called the osmotic pressure of the solution with respect to the membrane.

Osmotic pressure (like vapor pressure lowering and freezing-point depression) is a colligative property, meaning that the number of particles in solution is more important than the type of particles. One molecule of albumin (molecular weight 70,000) contributes as much to osmotic pressure as one molecule of glucose or one sodium ion. At equilibrium all molecules in a solution have achieved the same average kinetic energy, meaning that molecules with a smaller mass have higher average velocity. Thus, a one molar solution of NaCl will result in twice the osmotic pressure as a one molar solution solution of glucose because Na+ and Cl ions exert osmotic pressure as independent particles.

Solute concentrations are generally expressed in terms of molarity (moles of solute per liter of solution). The osmolarity of a solution is the product of the molarity of the solute and the number of dissolved particles produced by the solute. A one molar (1.0M, one mole per liter) solution of CaCl2 is a three osmolar (three osmoles per liter) solution because of the Ca2+ ion plus the two Cl ions produced when CaCl2 is added to water. Osmolarity, the number of solute particles per liter has been mostly replaced in practice by osmolality, the number of solute particles per kilogram. (For dilute solutions the values of the two are very close.) For describing solute concentrations in body fluids it is more convenient to use thousandths of osmoles, milli-osmoles (mOsm). Total solute osmolality of intracellular fluid, interstitial fluid or plasma is roughly 300mOsm/kgH2O. About half of the osmolality of intracellular fluid is due to potassium ions and associated anions, whereas about 80% of the osmolality of interstitial fluid and plasma is due to sodium and chloride ions.

As stated above, both osmotic pressure and freezing point depresssion are colligative properties. All colligative properties are convertible. One osmole of any solute will lower the freezi
ng point of water by 1.858C. For this reason, a 0.9% NaCl solution is 0.154molar or about 308mOsm/kgH2O, and will lower the freezing point of water by about 0.572C.

The osmolality of a solution is an absolute quantity that can be calculated or measured. The tonicity of a solution is a relative concept that is associated with osmotic pressure and the ability of solutes to cross a semi-permeable membrane. Thus, tonicitiy of a solution is relative to the particular solutes and relative to a particular membrane specifically relative to whether the solutes do or do not cross the membrane. Cell membranes are the membranes of greatest biological significance. Whether a cell shrinks or swells in a solution is determined by the tonicity of the solution, not necessarily the osmolality. Only when all the solutes do not cross the semi-permeable membrane does osmolality provide a quantitative measure of tonicity. It is common to speak as if tonicity and osmolality are equivalent because body fluid solutes are often impermeable. Each mOsm/kgH2O of fluid contributes about 19mmHg to the osmotic pressure.

A solution is said to be isotonic if cells neither shrink nor swell in that solution. Both 0.9%NaCl (physiological saline) and 5%glucose (in the absence of insulin) are isotonic solutions (roughly 300mOsm/kgH2O of impermeable solute). (In the presence of insulin, 5%glucose is a hypotonic solution because insulin causes glucose to cross cell membranes.) Hypertonic solutions cause cells to shrink as water rushes out of cells into the solute, whereas cells placed in hypotonic solutions cause the cells to swell as water from the solution rushes into the cells.

An exact calculation of the osmolality of plasma gives 308mOsm/kgH2O, but the freezing point depression of plasma (0.54C) indicates an osmolality of 286mOsm/kgH2O. Interaction of ions reduces the effective osmolality. Sodium ions (Na+) and accompanying anions (mostly Cl & HCO3) account for all but about 20mOsm/kgH2O of plasma osmolality. Plasma sodium concentration is normally controlled by plasma water content (thirst, etc.)[BMJ; Reynolds,RM; 332:702-705 (2006)]. Normal serum Na+ concentration is in the 135 to 145millimole per liter range, with 135mmol/L being the threshold for hyponatremia. Intracellular sodium concentration is typically about 20mmol/L about one-seventh the extracellular concentration. Glucose and urea account for about 5mOsm/kgH2O. Osmolality of plasma is generally approximated by doubling the sodium ions (to include all associated anions), adding this to glucose & urea molecules, and ignoring all other molecules as being negligible. Protein contributes to less than 1% of the osmolality of plasma. (Cells contain about four times the concentration of proteins as plasma contains.)

Although ethanol increases the osmolality of a solution, it does not increase the tonicity because (like water) ethanol crosses cell membranes. A clinical hyperosmolar state without hypertonicity can occur with an increase in extracellular ethanol (which diffuses into cells)[ MINERVA ANESTESIOLOGICA; Offenstadt,G; 72(6):353-356 (2006)]. Glycerol also readily crosses cell membranes, but it does so thousands of times more slowly than water which means that glycerol is "transiently hypertonic" (only isotonic at equilibrium). Ethylene glycol crosses red blood cell membranes about six times faster than glycerol (and sperm cell membranes four times faster than glycerol). Actually. even for water there is a finite time for hydraulic conductivity across cell membranes.

Cells placed in a "transiently hypertonic" solution (containing solutes that slowly cross a membrane) will initially shrink rapidly as water leaves the cell, and gradually re-swell as the solute slowly enters the cell (the "shrink/swell cycle"). As shown in the diagram for mouse oocytes at 10C, water leaves the cell in the first 100seconds, whereas 1.5Molar ethylene glycol (black squares) or DMSO (DiMethylSulfOxide, white squares) take 1,750seconds to restore the volume to 85% of the original cell volume[CRYOBIOLOGY; Paynter,SJ; 38:169-176 (1999)]. Even if a cell does not burst or collapse due to osmotic imbalance, a sudden change in osmotic balance can injure cells. Nonetheless, cells are somewhat tolerant of hypotonic solutions. Granulocytes are particularly sensitive to osmotic stress, but granulocyte survival is not significantly affected by hypertonic solutions until the osmolality of impermeant solutes approaches twice physiological values (about 600mOsm/kgH2O)[AMERICAN JOURNAL OF PHYSIOLOGY; Armitage WJ; 247(5Pt1):C373-381 (1984)].

PC3 cells show almost no decline of survival upon exposure to 5,000mOsm/kgH2O NaCl for 60minutes at 0C, and show nearly 85% cell survival on rehydration. Nearly 85% survive 9,000mOsm/kgH2O NaCl for 60minutes at 0C, but less than 20% survive rehydration. But although at 23C most cells survive exposure to 5,000mOsm/kgH2O NaCl for 60minutes, only about a third of cells survive rehydration. At 23C and 9,000mOsm/kgH2O NaCl only about half of cells survive 60 minutes and no cells survive rehydration, indicating the protective effect of low temperature against osmotic stress. Water flux at 23C was the same for 9,000mOsm/kgH2O as for 5,000mOsm/kgH2O, and hypertonic cell survival was not affected by the rate of concentration increase[CRYOBIOLOGY; Zawlodzka,S; 50(1):58-70 (2005)].

Hyperosmotic stress damages not only cell membranes, but damages cytoskeleton, inhibits DNA replication & translation, depolarizes mitochondria, and causes damage to DNA & protein. Heat shock proteins and organic osmolytes (like sorbitol & taurine) are synthesized as protection against hyperosmotic stress. Highly proliferative cells (like PC3) suffer from osmotic stress more than less proliferative cells because the latter can mobilize cellular defenses more readily due to fewer cells undergoing mitosis at the time of osmotic stress[PHYSIOLOGICAL REVIEWS; Burg,MB; 87(4):1441-1474 (2007)].

An important distinction to remember in replacing body fluids is the distinction between two kinds of swelling (edema): cell swelling and tissue swelling. Cell swelling occurs when there is a lower concentration of dissolved membrane-impermeable solutes outside cells than inside cells. To prevent either shrinkage or swelling of a cell there must be an osmotic balance of molecules & ions between the liquids outside the cell & inside the cell. Capillary walls are semipermeable membranes that are permeable to most of the small molecules & ions that will not cross cell membranes, but are impermeant to large molecules referred to as colloid (proteins). The colloid osmotic pressure on capillary walls due to proteins is called oncotic pressure. For normal human plasma oncotic pressure is about 28mmHg, 9mmHg of which is due to the Donnan effect which causes small anions to diffuse more readily than small cations because the small cations are attracted-to (but not bound-to) the anionic proteins. About 60% of total plasma protein is albumin (30 to 50 grams per liter), the rest being globulins. But albumin accounts for 75-80% of total intravascular oncotic pressure. Tissue swelling occurs when fluids leak out of blood vessels into the interstitial space (the space between cells in tissues). Injury to blood vessels can result in tissue swelling, but tissue swelling can also result from water leaking out of vessels when there is nothing (like albumin) to prevent the leakage.

Both forms of edema (cell & tissue swelling) can impede perfusion considerably, and is frequently a problem in cryonics patients who have suffered ischemic or other forms of blood vessel damage. Maintain
ing osmotic balance of the fluids outside & inside cells is as important as maintaining oncotic balance, ie, balance of fluids inside & outside of blood vessels.

Much of the isotonicity of the intracellular and extracellular fluids is maintained by the sodium pump in cell membranes, which exports 3sodium ions for every 2potassium ions imported into cells. Proteins in cells are more osmotically active than interstitial fluid proteins. Because of the Donnan effect the sodium pump is required to prevent cell swelling. When ischemia deprives the sodium pump of energy, cells swell from excessive intracellular sodium (because sodium attracts water more than potassium does) resulting in edema. Inflammation can also cause cell swelling due to increased membrane permeability to sodium and other ions. Interstitial edema can occur when ischemia or inflammation increases capillary permeability leading to leakage of larger plasma solutes into the interstitial space.

[For further details on the sodium pump see MEMBRANE POTENTIAL, K/Na-RATIOS AND VIABILITY]

Near the hypothalamus of the brain are osmoreceptors (outside the blood-brain barrier) that monitor blood osmolality, which is normally in the range of 280-295mOsm/kgH2O. A 2% increase in plasma osmotic pressure can provoke thirst. An increase in plasma osmolality can indicate excessive loss of blood volume. To compensate, the posterior pituitary (neurohypophysis) secretes the hormone 8arginine vasopressin (AVP), which is two hormones in one hence the two names vasopressin and anti-diuretic hormone. AVP action on the V1 receptors on blood vessels causes vasoconstriction (vasopressin). AVP action on the V2 receptors of the kidney causes water retention (anti-diuretic hormone). Deficiency in AVP secretion can lead to diabetes incipidus, so called because the excessively excreted urine is tasteless (incipid), in contrast to the sweet (glucose-laden) urine of diabetes mellitus. Cortisol opposes AVP action on excretion, leading to dehydration and excessive urination of fluid. Reduced blood flow to the kidney stimulates release of renin, which catalyzes the production of angiotensin. Like AVP, angiotensin causes vasoconstriction and kidney fluid retention.

Rats subjected to experimental focal ischemia have shown reduced edema when treated with an AVP antagonist[STROKE; Shuaib,A; 33(12):3033-3037 (2002)]. Hypertonic saline(7.5%) has been shown to halve plasma AVP levels in experimental rats, whereas mannitol(20%) had no effect[JOURNAL OF APPLIED PHYSIOLOGY; Chang,Y; 100(5):1445-1451 (2006)]. Increases in plasma osmolality due to urea or glycerol have no effect on plasma AVP levels[JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY; Verbalis,JG; 18(12):3056-3059 (2007)]. The effect of hypertonic saline on osmotic edema due to AVP in a cryonics patient would likely be negligible because of negligible hormone release and transport. So some of the advantage of hypertonic saline over mannitol seen in clinical trials would not occur in cryonics cases.

The net movement of fluid across capillary membranes due to hydrostatic and oncotic forces can be described by the Starling equation. The Starling equation gives net fluid flow across capillary walls as a result of the excess of capillary hydrostatic pressure over interstitial fluid hydrostatic pressure, and capillary oncotic pressure over interstitial fluid oncotic pressure modified by the water permeability of the capillary. For a normal (animate) person, the hydrostatic pressure (blood pressure) at the arterial end of a capillary is about 35mmHg. The hydrostatic pressure drops in a linear fashion across the length of the capillary until it is about 15mmHg at the venule end. The net oncotic pressure within the capillary is about 25mmHg across the entire length of the capillary. Thus, for the first half of the capillary there is a net loss of fluid into the interstitial space until the hydrostatic pressure has dropped to 25mmHg. For the second half of the capillary there is a net gain of fluid into the capillary from the interstitial space. The flow of fluid into the interstitial space in the first half of the capillary is associated with the delivery of oxygen & nutrient to the tissues, whereas the flow of fluid from the interstitial space into the second half of the capillary is associated with the removal of carbon dioxide and other waste products.

Actually, there is a tiny (tiny relative to the total diffusion back and forth across the capillary wall) net flow of fluid from the capillaries to the interstitial fluid which is returned to the blood vessels by the lymphatic system. The lymphatic vessels contain one-way valves and rely on skeletal muscle movement to propel the lymphatic fluid. Infectious blockage of lymph flow can produce edema. A person sitting for long periods (as during a long trip) or standing a long time without moving may experience swollen ankles due to the lack of muscle activity. Swollen ankles is also a frequent symptom of the edema resulting from congestive heart failure. Venous pressure is elevated by the reduced ability of the heart to pull blood from the venous system, whereas vasoconstriction can better compensate to maintain pressure on the arterial side. Reduced albumin production by the liver as a result of cirrhosis or other liver diseases can reduce plasma osmolality such that the reduced oncotic pressure results in edema typically swollen ankles, pulmonary edema and abdomenal edema (ascites).

The Starling forces are different for the blood-brain barrier (BBB) than they are for other capillaries of the body because of the reduced permeability to water (lower hydraulic conductivity) and the greatly reduced permeability to electrolytes. The osmotic pressure of the plasma and interstitial fluid effectively become the oncotic pressures.

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A critical distinction is made in fluid mechanics between laminar flow and turbulent flow in a pipe. For laminar flow elements of a liquid follow straight streamlines, where the velocity of a streamline is highest in the center of the vessel and slowest close to the walls. Turbulent flow is characterized by eddies & chaotic motion which can substantially increase resistance and reduce flow rate. The Reynolds number is an empirically determined dimensionless quantity which is used to predict whether flow will be laminar or turbulent with 2000 being the approximate lower limit for turbulent flow. Transient localized turbulence can be induced at a Reynolds number as low as 1600, but temporally peristant turbulence forms above 2040[SCIENCE; Eckhart,B; 333:165 (2011)].

Turbulent flow could potentially be a problem in cryonics if it reduced perfusion rate or increased the amount of pressure required to maintain a perfusion rate. It is doubtful that turbulent flow ever plays a role in cryonics perfusion, however. Even for a subject at body temperature (37C) Reynolds numbers in excess of 2000 are only seen in the very largest blood vessels: the aorta and the vena cava.

The formula for Reynolds number is: v D Re = ------ = fluid density (rho) v = fluid velocity D = vessel diameter = fluid viscosity

The fact that diameter (D) is in the numerator indicates that only high diameter vessels have high Reynolds number. Velocity (v), also in the numerator, is highest in the aorta & arteries. But the use of cryoprotectants and the increase in viscosity () with declining temperature essentially guarantee that turbulent flow will not occur in a cryonics patient.

More serious for cryonics is the Hagen-Poisseuille Law, which describes the
relationship between flow-rate and driving-pressure: pressure X (radius)4 Flow Rate = ---------------------- length X viscosity

Typically in cryonics the flow rate will be one or two liters per minute when the pressure is around 80mmHg. But because flow rate varies inversely with viscosity and varies directly with pressure, pressure must be increased to maintain flow rates when cryoprotectant viscosity increases with lowering temperature. This poses a serious problem because blood vessels become more fragile with lowering temperature. If blood vessels burst the perfusion can fail.

At 20C glycerol is about 25% more dense (=rho, in the numerator) than water. But the role of viscosity is far more dramatic, with high viscosity in the denominator reducing Reynolds number considerably. The viscosity of water approximately doubles from 37C to 10C, but the viscosity of glycerol increases by a factor of ten (roughly 4Poise to 40Poise). At 37C glycerol is nearly 600 times more viscous than water, but at 10C it is about 2,600 times more viscous.

Although turbulence is not a concern in cryonics, the increase in viscosity of cryoprotectant with lowering temperature certainly is. Fortunately, the newer vitrification mixtures are less viscous than glycerol.

The most common strategy in cryonics has been to cool the patient from 37C to 10C as rapidly as possible and to perfuse with cryoprotectant at 10C. Lowering body temperature reduces metabolism considerably, thereby lessening the amount of oxygen & nutrient required to keep tissues alive. Cryoprotectant toxicity drops as temperature declines. But the very dramatic more-than-exponential increase in cryoprotectant viscosity with lowering temperature poses a significant problem for effective perfusion. When open circuit perfusion is used, a higher temperature may be preferable because the opportunity for diffusion time into cells is so limited (about 2hours 1hour for the head, 1hour for the body) although ischemic damage is difficult to quantify.

With closed circuit perfusion, the perfusion times are longer up to 5hours. If a good carrier solution is used for the cryoprotectant the tissues may receive adequate nutrient. This, along with the oxygen carrying-capacity of water at low temperature, may limit ischemic damage while allowing time for cells to become fully loaded with cryoprotectant. If ischemic damage can be safely prevented in perfusion, the only critical issues for temperature selection are the relative benefits of reduced cryoprotectant toxicity at lower temperatures as against increased chilling injury. The fact that the more-than-exponential increase in viscosity with lowering temperature will increase perfusion time will not be problematic if the risk of ischemia is minimized.

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Typically a cryonics patient deanimates at a considerable distance from a cryonics facility and must be transported before cryoprotectants can be perfused. Blood could be washed-out and replaced with an isotonic (ie, osmotically the same as saline) solution, such as Ringer's solution. The patient is then transported to the cryonics facility at water-ice temperature. Freezing must be avoided because ice crystals would damage cells & blood vessels to such an extent as to prevent effective cryoprotectant perfusion. Water-ice temperature will not freeze tissues because tissues are salty (salt lowers the freezing point below 0C).

As body temperature approaches 10C, metabolic rate has slowed greatly and the oxygen-carrying capacity of blood hemoglobin is no longer required. Cool water, in fact, may carry adequate dissolved oxygen at low temperatures. (Water near freezing temperature can hold nearly three times as much dissolved oxygen as water near boiling temperature. Oxygen is about five times more soluble in water than nitrogen.) The tendency of blood to agglutinate and clog blood vessels becomes a serious problem at low temperature so the blood should be replaced if this does not cause other problems (such as delay and reperfusion injury.)

Replacing blood with a saline-like solution for patient transport, however, does not do a good job of maintaining tissue viability or preventing edema and would likely cause reperfusion injury. For this reason an organ preservation solution such as Viaspan, rather than Ringer's solution, has been used for cryopatient transport. Blood is not simply an isotonic solution carrying blood cells. Blood contains albumin, which attracts water and keeps the water from leaving blood vessels and going into tissues (maintains oncotic balance). Tissues which are swollen by water (edematous tissues) resist cryoprotectant perfusion. One of the most important ingredients in Viaspan preventing edema is HydroxyEthyl Starch (HES), which attracts water in much the way albumin attracts water acting as an oncotic agent by keeping water in the blood vessels. Viaspan contains potassium lactobionate to help maintain osmotic balance. Because HES is difficult to obtain and can cause microcirculatory disturbances, PolyEthylene Glycol (PEG) has been used in organ preservation solutions as a replacement for HES with good results[THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS; Faure,J; 302(3):861-870 (2002) and LIVER TRANSPLANTATION; Bessems,M; 11(11):1379-1388 (2005)].

The same benefit might not apply to cryonics patients, however, because of the prevalence of endothelial damage due to ischemia. Larger "holes" in the vasculature can mean that a larger molecular weight molecule is required for oncotic support. HES molecular weight is about 500,000, whereas the molecular weight for PEG used in organ replacement solutions is more like 20,000. Albumin (which has a molecular weight of about 70,000) provides most of the oncotic support in normal physiology. A PEG with molecular weight of 500,000 would be far too viscous and will form a gel. HES has the benefit of being large enough to always provide oncotic support while being much less viscous than PEG of equivalent molecular weight.

Viaspan (DuPont Merck Pharmaceuticals) contains other ingredients to maintain tissue viability, such as glucose, glutathione, etc. (the full formula can be found on the Viaspan website). Viaspan is FDA approved for preservation of liver, kidney & pancreas, but is used off-label for heart & lung transplants. Viaspan is being challenged in the marketplace for all these applications by the Hypothermosol (Cryomedical Sciences, BioLife Technologies) line of preservation solutions.

Rather than use these expensive commercial products, Alcor and Suspended Animation, Inc. use a preservation solution developed by Jerry Leaf & Mike Darwin called MHP-2. MHP-2 is so-called because it is a Perfusate (P) which contains mannitol (M) as an extracellular osmotic agent and HEPES (H), a buffer to prevent acidosis which is effective at low temperature. MHP-2 also contains ingredients to maintain tissue viability and hydroxyethyl starch as an oncotic agent to prevent edema. Lactobionate permeates cells less than mannitol and can thus maintain osmotic balance for longer periods of time, but mannitol is much less expensive. Mannitol also has an additional effect in the brain. Because of the unique tightness of brain capillary endothelial cell junctions ("blood brain barrier"), little mannitol leaves blood vessels to pass into the brain. This means that mannitol can act like an oncotic agent for the brain. If the blood brain barrier is intact, mannitol will suck water out of the extravascular space. The brain is the only place that mannitol can do this, and that is why a mannitol is eff
ective for inhibiting edema of the brain but only if there is not extensive ischemic damage to the blood brain barrier. (Mannitol has yet another benefit in that it scavenges hydroxyl radical [CHEM.-BIOL. INTERACTIONS 72:229-255 (1989)]).

(For the formula of MHP-2 see TableII of CryoMsg4474 or TableVII of CryoMsg2874 which also contains the formula for Viaspan in TableV.)

The initial perfusate can also contain other ingredients to assist in reducing damage to the cryonics patient. Anticoagulants can reduce clotting problems, and antibiotics can reduce bacterial damage. Damaging effects of ischemia can be reduced with antioxidants, antiacidifiers, an iron chelator and a calcium channel blocker.

Both Alcor and Suspended Animation, Inc. use an Air Transportable Perfusion(ATP) system of equipment which allows them to do blood washout in locations remote from any cryonics facilty by using equipment that can easily be carried on an airplane. There is a video demonstration of an ATP on YouTube.

[For further details on organ preservation solution see ORGAN TRANSPLANTATION SOLUTION]

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Cryoprotectants are used in cryonics to reduce freezing damage by prevention of ice formation (see Vitrification in Cryonics ). Cells are much more permeable to water than they are to cryoprotectant. Platelets & granulocytes, for example, are 4,000 times more permeable to water than they are to glycerol[CRYOBIOLOGY; Armitage,WJ; 23(2):116-125 (1986)]. When a cell is exposed to high-strength cryoprotectant, osmosis causes water to rush out of the cells, causing the cells to shrink. Only very gradually does the cryoprotectant cross cell membranes to enter the cell (the "shrink/swell cycle"). For isolated cells, the halftime (time to halve the difference between a given glycerol concentration in a granulocyte and the maximum possible concentration) is 1.3minutes[EXPERIMENTAL HEMATOLOGY; Dooley,DC; 10(5):423-434 (1982)] but tissues & organs would require more time because their cells are less accessible. Even after equilibration, however, the concentration of glycerol inside neutrophilic granulocytes never rises above 78% of the concentration outside the cells.

As shown in the diagram for mature human oocytes placed in a 1.5molar DMSO solution, the shrink/swell cycle is highly temperature dependent, happening with slower speed of recovery and with greater volume change at lower temperatures[HUMAN REPRODUCTION; Paynter,SJ; 14(9):2338-2342 (1999)]. This creates tough choices in cryonics, because cryoprotectants are more toxic at higher temperatures.

Proliferation of cultured kidney cells declines linearly with increasing osmolality due to urea & NaCl above 300mOsm/kgH2O, but the effect of added glycerol on cell growth is much less[AMERICAN JOURNAL OF PHYSIOLOGY; Michea,L; 278(2):F209-F218 (2000)]. Kidney cells which invivo can tolerate osmolalities of around 300mOsm/kgH2O do not survive over 300mOsm/kgH2O invitro, possibly because of more rapid proliferation[PHYSIOLOGICAL REVIEWS; Burg,MB; 87(4):1441-1474 (2007)].

Cells subjected to high levels of cryoprotectants can be damaged by osmotic stress. Quantifying osmotic damage has been a challenge for experimentalists who must distinguish between electrolyte damage, cryoprotectant toxicity, cell volume effects and osmotic stress. Concerning the last two, osmotic damage due to cell shrinkage may be distinguished from osmotic damage as a result of the speed at which the cryoprotectant crosses the cell membrane, ie, by the membrane permeability to the cryoprotectant. Cryoprotectants with lower permeabilities can cause more osmotic stress than cryoprotectants with high permeability.

Membrane permeabilities of a variety of nonelectrolytes (including cryoprotectants) have been studied on a number of cell types, including human blood cells[THE JOURNAL OF GENERAL PHYSIOLOGY; Naccache,P; 62(6):714-736 (1973)]. Critical factors determining membrane permeability are lipid solubility of the substance (which increases permeability) and hydrogen bonding (which decreases permeability). In general, permeability decreases as the molecular size of the substance increases. In contrast to blood cells, human sperm is more than three times more permeable to glycerol than to DMSO[BIOLOGY OF REPRODUCTION; Gilmore,JA; 53(5):985-995 (1995)]. For both blood cells and sperm cells permeability to ethylene glycol is very high compared to the other common cryoprotectants. Yet for mature human oocytes propylene glycol has the highest permeability and ethylene glycol has the lowest permeability of the most commonly used oocyte cryoprotectants[HUMAN REPRODUCTION; Van den Abbeel,E; 22(7):1959-1972 (2007)]. In contrast to human oocytes, however, for mouse oocytes ethylene glycol(EG) permeability is comparable to that of DMSO, propylene glycol(PG), and acetamide(AA), but not glycerol(Gly)[JOURNAL OF REPRODUCTION AND DEVELOPMENT; Pedro,PB; 51(2):235-246 (2005)].

Water and cryoprotectants both cross cell membranes more slowly at lower temperatures. Cryoprotectants slow the passage of water across cell membranes. Glycerol, DMSO and ethylene glycol all reduce the rate at which water crosses human sperm cell membranes by more than half[BIOLOGY OF REPRODUCTION; Gilmore,JA; 53(5):985-995 (1995)].

Aside from the choice of cryoprotectants, a major concern is the way cryoprotectant is administered. For example, glycerol (the standard cryoprotectant used in cryonics for many years) can either be administered full-strength or it can be introduced in gradually increasing concentrations. Under optimum conditions, glycerol results in 80% vitrification and 20% ice formation. Glycerol has been replaced by better cryoprotectants that can vitrify without any ice formation, but I will typically use glycerol as my example cryoprotectant. A patient should probably not be perfused with a 100% solution of glycerol or other cryoprotectant because of the possibility of osmotic damage. It is prudent to begin perfusion with low concentrations of cryoprotectant because water can diffuse out of cells thousands of times more rapidly than cryoprotectant diffuses into cells. Using gradually increasing concentrations of cryoprotectant (ramping) prevents the osmotic damage this differential could cause.

Human granulocytes (which are more vulnerable to osmotic stress or shrinkage than most other cell types) can experience up to 600mOsm/kgH2O hypertonic solution (which shrinks cells to 68% of normal cell volume) for 5minutes at 0C with no more than 10% of the cells losing membrane integrity. But at about 750mOsm/kgH2O (NaCl) or 950mOsm/kgH2O (sucrose) less than half of granulocytes display intact membranes when returned to isotonic solution. Nonetheless, the cells did not display lysis if retained in hyperosmotic medium. In fact, granulocytes could tolerate up to 1400mOsm/kgH2O if not subsequently diluted to less than 600mOsm/kgH2O[AMERICAN JOURNAL OF PHYSIOLOGY; Armitage WJ; 247(5Pt1):C373-381 (1984)]. A subsequent confirming study showed that rehydration of PC3 cells shrunken by NaCl solution creates more osmotic damage than the initial dehydration[CRYOBIOLOGY; Zawlodzka,S; 50(1):58-70 (2005)]. Cell survival after rehydration was higher at 0C than at 23C.

Although toxic effects of 2M (17%w/w) glycerol on granulocytes are quite evident at 22C, almost no toxic effect is seen at 0C[CRYOBIOLOGY; Frim,J; 20(6):657-676 (1983)]. For no mammalian cells other than granulocytes is 2Molar glycerol toxic. Nonetheless, abrupt addition of only 0.5Molar glycerol at 0C resulted in only 40% of granulocytes surviving when slowly diluted to isotonic solution a
nd warmed to 37C. Only 20% of granulocytes survived this treatment when 1Molar or 2Molar glycerol were added (there was no difference in survival between the two concentrations). But if sucrose or NaCl was added to keep the granulocytes shrunken to 60% of normal cell volume, almost all granulocytes survived when incubated to 37C. Insofar as the transient shrinkage of granulocytes due to glycerol is not less than 85% of normal cell volume, it seems unlikely that cell shrinkage can account for the damage[AMERICAN JOURNAL OF PHYSIOLOGY; Armitage WJ; 247(5Pt1):C382-389 (1984)].

Human spermatazoa tolerate much higher osmolality than granulocytes. Sperm cells can experience up to 1000mOsm/kgH2O hypertonic solution for 5minutes at 0C with no more than 10% of the cells losing membrane integrity. At about 1500mOsm/kgH2O (NaCl, white circles) or 2500mOsm/kgH2O (sucrose, black circles) less than half of sperm cells display intact membranes when returned to isotonic conditions. But 80% of sperm cells showed intact cell membrane after exposure to 2500mOsm/kgH2O at 0C if maintained at hypertonicity rather than restored to isotonic solution (NaCl & sucrose, triangles). Sperm cells gradually returned to isotonic solution following exposure to 1.5Molar glycerol at 22C showed only 3% lysis, whereas 20% of sperm cells lysed if the return to isotonic was sudden. No lysis was seen for sperm not returned to isotonic medium. At nearly 5000mOsm/kgH2O glycerol (about 4.5Molar) 17% of sperm cells showed lysis (had loss of membrane integrity) at 0C and 10% had lysis at 8C if not returned to isotonic media[BIOLOGY OF REPRODUCTION; Gao,DY; 49(1):112-123 (1993)]. For cryonics purposes it would be best to maintain cells in a hypertonic condition to maximize potential viability during cryogenic storage.

Cells from mouse kidney (IMCD, Inner Medullary Collecting Duct) can be killed by NaCl or urea that is 700mOsm/kgH2O, but the death is apoptotic and takes up to 24hours. The IMCD cells can tolerate up to 900mOsm/kgH2O of urea and NaCl in combination because of activation of complementary cellular defenses (including heat-shock protein)[ AMERICAN JOURNAL OF PHYSIOLOGY; Santos,BC; 274(6):F1167-F1173 1998)].

Nearly half of mouse fibroblasts displayed cell membrane lysis after restoration to isotonicity following exposure to the equivalent of 3600mOsm/kgH2O of osmotic stress from rapid addition of 4Molar (30%w/w) DMSO at 0C. Few cells were damaged by slow addition of the DMSO[BIOPHYSICAL JOURNAL; Muldrew,K; 57(3):525-532 (1990)].

Human corneal epithelial cells could tolerate 4.3M (37%w/w) glycerol with only 2% cell loss at 4C if the cells were subjected to gradually increasing (ramped) concentration (doubling osmolality in about 13minutes), but for stepped increases of 0.5M every 5minutes above 2M (17%w/w) to 3.5M (30%w/w) glycerol at 0C there was a 27% cell loss. For the same ramped method with DMSO there was a 6% cell loss at 2M (15%w/w) and a 15% cell loss at 3M (23%w/w). The same stepped method for DMSO resulted in a 1.5% cell loss for cells stepped from 2M to 3.5M (27%w/w) and a 22% cell loss for cells stepped from 2M to 4.3M (33%w/w). In all cases cell viability was assessed after washout and three days of incubation at 37C[CRYOBIOLOGY; Bourne,WM; 31(1):1-9 (1994)]. (Conversion of glycerol molarity to %w/w was approximated by multiplying by 8.6 and for DMSO was approximated by multiplying by 7.6)

In the context of cryonics it should be remembered that cells are not being returned to body temperature and need not be returned to isotonicity before cryoopreservation. There would be little time for apoptosis, and most cells would be far better preserved at low temperature and in hyperosmolar solution. Future technologies may be able to prevent apoptosis and have better methods for restoring irreplaceable cells to normal temperatures and osmolalities. For neurons, even abrupt stepped perfusion with cryoprotectant is likely to effectively result in ramped perfusion when allowances are made for the diffusion times required across blood vessels (blood brain barrier) and interstitial space. A more worrisome effect from the point of view of cryonic cryoprotectant perfusion is the effect of the cryoprotectants on vessel endothelial cells notably the effect on edema and vascular compliance.

Cell shrinkage may directly damage the cell (and cell membrane) due to structural resistance from the cell cytoskeleton and high compression of other cell constituents[HUMAN REPRODUCTION; Gao,DY; 10(5):1109-1122 (1995)]. Aside from membrane damage, other forms of cellular damage occur due to hypertonic environments, including cross-linking of intracellular proteins subsequent to cell dehydration. Bull sperm lose motility (often only temporarily) in a less hypertonic medium than one causing membrane damage[JOURNAL OF DAIRY SCIENCE; Liu,Z; 81(7):1868-1873 (1998)]. Osmotic stress can depress mitochondrial membrane potential in a manner that is mostly reversible after restoration to isotonic conditions[PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES (USA); Desai,BN; 99(7):4319-4324 (2002)]. Human oocytes subjected to 600mOsm/kgH2O sucrose showed 44% of metaphaseII spindles having abnormalities[HUMAN REPRODUCTION; Mullen,SF; 19(5):1148-1154 (2004)]. Hypertonic solutions can trigger apoptosis[AMERICAN JOURNAL OF PHYSIOLOGY; Copp,J; 288(2):C403-C415 (2005)].

Despite these other types of damage due to hyperosmolality, the greatest risks in cryoprotectant perfusion in cryonics are those associated with membrane damage and edema due to cell swelling. The evidence that maintaining hypertonicity is more protective of cells than returning to isotonic conditions, and the desire to minimize edema during perfusion seem to make it advisable in cryonics to perfuse in hypertonic conditions.

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Once the patient is at the cryonics facility the transport solution can be replaced with a cryoprotectant solution. A perfusion temperature of 10C gives the best tradeoff of avoiding the high viscosity of lower temperatures and at the same time limiting the ischemic tissue degradation, chilling injury, and cryoprotectant toxicity that would be seen at higher temperatures. (Cryonicists usually worry more about ischemic damage than cryoprotectant toxicity due to a belief that ischemic damage has a greater likelihood of being irreversible irreparable by future molecular-repair technology.)

Cryoprotectants should be sterilized to prevent the growth of bacteria. Sterilization of cryoprotectants by heating can cause the formation of carbon-carbon double-bonds, which are evident by a yellowing of the cryoprotectant. Only a few such double-bonds can produce the yellow appearance, so the fact of yellowing is not evidence that the cryoprotectant is no longer serviceable. But a preferable method of cryoprotectant sterilization is filtration through a 0.2micron filter.

Rapid addition of cryoprotectant causes endothelial cells to shrink thereby breaking the junctions between the cells[CRYOBIOLOGY; Pollock,GA,; 23(6):500-511 (1986)]. On the other hand, endothelial cell shrinkage by hypertonic perfusate can increase capillary volume, thereby increasing blood flow as long as excessive vascular damage does not occur. Blood and clots are often observed to be dislodged during cryoprotectant perfusion in cryonics cases. For cryonics purposes some vascular damage may actually be an advantage insofar as it increases diffusion and vascular repair may be an easy task for future science. In fact, the breakdown of the blood-brain barrier in the 1.8-2.2 molar glycerol range is essential for perfusion of the brain as long as damag
ing tissue edema (swelling) can be avoided. Aquaporin (water channel) expression in the blood-brain barrier could be a safer means of allowing cryoprotectants into the brain[CRYOBIOLOGY; Yamaji,Y; 53(2):258-267 (2006)].

Closed-circuit perfusion (with perfusion solution following a circuit both inside & outside the patient's body) is contrasted with the open-circuit perfusion used by funeral directors for embalming. In the open-circuit perfusion of embalming, fluid is pumped into a large artery of the corpse and forces-out blood from a large vein and this blood is discarded.

A closed-circuit perfusion, as illustrated in the diagram, can be set up at low cost for gradual introduction of cryoprotectant into cryonics patients. As shown in the diagram, the perfusion circuit bypasses the heart. Perfusate enters the patient through a cannula in the femoral (leg) artery and exits from a cannula in the femoral vein on the same leg. Flowing upwards (opposite from the usual direction) from the femoral artery and up through the descending aorta, the perfusate enters the arch of the aorta (where blood normally exits the heart), but is blocked from entering the heart. Instead, the perfusate flows (in the usual direction) through the distribution arteries of the aorta, notably to the head and brain. Returning in the veins (in the usual direction), the perfusate nontheless again bypasses the heart and flows downward (opposite from the usual direction) to the femoral vein where it exits. A better alternative to the femoral circuit, however, is to surgically open the chest to cannulate the heart aorta (for input) and atrium (for output).

Although it is not shown in the diagram, there will be a pump in the circuit to maintain pressure and fluid movement. A roller pump, rather than an embalmer's pump, should be used. A roller pump achieves pumping action by the use of rollers on the exterior of flexible tubing that forces fluids through the tube without contaminating those fluids. Embalmer's pumps may use pressures much higher than those suitable for cryonics, resulting in blood vessel damage. Embalmer's pumps are also easily contaminated (and hard to clean), unless a filter is used. Contamination doesn't matter much in embalming, but in cryonics contaminants entering the patient through the pump can damage blood vessels, interfering with perfusion. If an embalmer's pump is used for cryonics purposes, ensure that the pressure can be lowered to a suitable level and that it is cleaned and sterilized. The main advantage of roller pumps, however, is the fact that they provide a closed circuit, whereas embalmer's pumps are open-circuit. Roller pumps are generally calibrated in litres per minute. Depending on the viscosity of the solution, a flow rate of 0.5 to 1.5litres per minute will be necessary to achieve the desired perfusion pressure of approximately 80mmHg to 120mmHg (physiological pressures).

Gaseous and particulate microemboli can produce ischemia in capillaries and arterioles. A study of patients having routine cardiopulmonary bypass surgery showed that 16% fewer patients had neuropsychological deficits eight weeks after the surgery when a 40micrometer arterial line filer had been used[STROKE; Pugsley,W; 25(7):1393-1399 (1994)]. Both roller pumps (peristaltic pumps) and centrifugal pumps can generate particles up to 25micrometers in diameter through spallation, although centrifugal pumps generate fewer particles[PERFUSION; Merkle,F; 18(suppl1):81-88 (2003)]. Filtration of perfusate with a 0.2micrometer filter prior to perfusion is a recommended way of removing potential microemboli, including bacteria. At room temperature 20micrometer diameter air bubbles take 1to6seconds to dissolve in water, although high flow rates and turbulence can increase microbubble formation[SEMINARS IN DIALYSIS; Barak,M; 21(3):232-238 (2008)]. De-airing of tubing before perfusion considerably reduces the possibility of microbubbles entering the patient[THE THORACIC AND CARDIOVASCULAR SURGEON; Stock,UA; 54(1):39-41 (2006)].

Mean Arterial Pressure (MAP) for an normal adult is regarded as being in the range of 50 to 150mmHg, and Cerebral Perfusion Pressure (CPP) is in the same range[BRITISH JOURNAL OF ANAETHESIA; Steiner,LA; 91(1):26-38 (2006)]. Vascular pressure normally drops to about 40mmHg in the arterioles, to below 30mmHg entering the capillaries, and is down to 3 to 6mmHg (Central Venous Pressure, CVP) when returning to the right atrium of the heart. Perfusing a cryonics patient at about 120mmHg should open capillaries adequately for good cryoprotectant tissue saturation without damaging fragile blood vessels.

Outside the patient, some of the drainage is discarded, but most is returned to a circulating (stirred) reservoir connected to a concentrated reservoir of cryoprotectant. The circulating reservoir is initially carrier solution which gradually becomes increasingly concentrated with cryoprotectant as the stirring and recirculation proceed. The circulating reservoir can be stirred from the bottom by a magnetic stir bar on a stir table and/or from the top by an eggbeater-type stirring device. The stirring will draw cryoprotectant from the cryoprotectant reservoir, and pumping of the perfusate should also actively draw liquid from the cryoprotectant reservoir. Gradually a higher and higher concentration of cryoprotectant is included in the perfusate and the osmotic shock of full-strength cryoprotectant is avoided.

The carrier solution for the cryoprotectant should perform similar tissue preservation functions as is performed by the transport solution, and should be carefully mixed with the cryoprotectant so as to avoid deviations from isotonicity which could result in dehydration or swelling & bursting of cells. The carrier solution will help keep cells alive during cryoprotectant perfusion.

An excellent carrier solution for cryonics purposes would be RPS-2 (Renal Preservation Solution number2), which was developed by Dr. Gregory Fahy in 1981 as a result of studies on kidney slices. More recently Dr. Fahy used RPS-2 as the carrier solution in cryopreserving hippocampal slices an indication that it is well-suited for brain tissue as well as for kidney. RPS-2 not only helps maintain hippocampal slice viability, it reduces the amount of cryoprotectant needed because it has cryoprotectant (colligative) properties of its own. The formulation of RPS-2 is: K2HPO4, 7.2mM; reduced glutathione, 5mM; adenine HCl, 1mM; dextrose, 180mM; KCl, 28.2mM; NaHCO3, 10mM; plus calcium & magnesium[CRYOBIOLOGY; Fahy,GM; 27(5):492-510 (1990)]. LM5 (Lactose-Mannitol5) is a carrier solution for use in vitrification solutions that include ice blockers. LM5 does not contain dextrose, which is believed to interfere with ice blockers.

The cryoprotectant reservoir will not in general contain pure cryoprotectant (although in principle it could), but rather a "terminal concentration" solution of cryoprotectant that is equal or slightly above the final target concentration. As perfusion proceeds and drainage to discard proceeds, the level of both reservoirs drops in tandem until both reservoirs are nearly empty, at which point the circuit concentration will have reached the cryoprotectant reservoir concentration. Provided that the two reservoirs are the same size and same vertical elevation, the gradient will be linear over time (if the drainage rate to discard was constant).

For cryoprotectant to perfuse into cells there must be constant exposure to cryoprotectant surrounding the cells and there must be pressure to maintain that exposure. In a living animal the heart maintains blood pressure that for
ces blood through the capillaries and forces nutrients into cells. A dead animal with no blood pressure and which is being perfused with cryoprotectant also requires pressure for the capillaries to remain open and for cryoprotectant to be maintained at high concentrations around cells.

Alcor found that closed-circuit perfusion must be maintained for 5-7 hours for full equilibration of glycerol, because the diffusion rate of water out of cells is thousands of times the rate at which glycerol enters cells. Of course, it would be possible to pump glycerol into a patient for 5-7 hours with open-circuit perfusion, but only by using thousands of dollars worth of glycerol. The newer vitrification cryoprotectants used by Alcor are vastly more expensive than glycerol. When using expensive cryoprotectants it makes far more sense to recirculate in a closed circuit. Closed-circuit perfusion also has the benefit of allowing for ongoing monitoring of physiological changes occurring in the patient's body during the perfusion process. Open-circuit with an inexpensive cryoprotectant has the advantage of avoiding recirculation of toxins.

Cryoprotectants, particularly glycerol, are viscous and cryoprotectants in high concentration are particularly viscous. The introduction of air bubbles into cryoprotectant solutions during pouring and mixing should be avoided because air emboli that enter the cryonics patient can block perfusion. Elimination of air bubbles from viscous cryoprotectant solutions is extremely difficult. Prevention is more effective than cure. Cryonicist Mike Darwin wrote about this problem and possible solutions in a 1994 CryoNet message.

Improper mixing of perfusate containing high levels of cryoprotectant can result in a phenomenon that appears to be high viscosity, but in reality is edema. If, for example, isotonic carrier solution is mixed half-and-half with cryoprotectant solution an open circuit perfusion may have to be halted when no further perfusate will go into the patient. The problem is caused not by viscosity, but by the fact that the isotonic solution became hypotonic due to dilution with cryoprotectant causing the cells to swell and forcing perfusion to end. In closed-circuit perfusion, the cryoprotectant concentrate reservoir contains cryoprotectant at about 125% the terminal concentration in a vehicle of isotonic carrier solution so that when reservoir concentrate is mixed with isotonic carrier there is no change in tonicity.

Newer cryoprotectants are less viscous than glycerol, so perfusions can be done in less time. After 15 minutes of perfusion with carrier solution, cryoprotectant concentration linearly increases at a rate of 50millimolar per minute until full concentration is reached in about two hours (a protocol developed on the basis of minimizing osmotic damage when perfusing kidneys). Perfusion is increased for an additional hour or two until the cryoprotectant has fully diffused into cells (as indicated by similarity of afflux and efflux cryoprotectant concentrations).

Only after a few hours of closed-circuit perfusion is the concentration of cryoprotectant exiting the cryonics patient equal to the concentration of cryoprotectant entering the patient. Only an extended period of sustained pressure will keep capillaries open, and otherwise facilitate diffusion of cryoprotectant into cells. And the exiting cryoprotectant concentration will equal the entering cryoprotectant concentration only when the tissues are fully loaded with cryoprotectant. A refractometer is used to verify that terminal cryoprotectant concentration has been reached in the brain.

(A refractometer measures the index of refraction of a liquid, ie, the ratio of the speed of light in the liquid and the speed of light in a vacuum (or air). Light changes speed when it strikes the boundary of two media, thus causing a change in angle if it strikes the new medium at an angle. Because the refractive index is a ratio of two quantities having the same units, it is unitless. Sodium vapor in an electric arc produces an excitation between the 3s and 3p orbitals resulting in yellow-orange light of 589nm what Joseph Fraunhofer called the "Dline". Insofar as the sodium "Dline" was the first convenient source of monochromatic light, it became the standard for refractometry. The refractive index of a liquid is thus a high-precision 5-digit number between 1.3000 and 1.7000 at a specific temperature, measured at the sodium Dline wavelength. For example, the refractive index of glycerol at 25C nD25 is 1.4730.)

Closed-circuit perfusion may be necessary for removal of water as well as loading of cryoprotectant if it is true that open-circuit perfusion cannot remove water effectively.

One could imagine that the additional time spent doing closed-circuit (rather than open-circuit) perfusion means increased damage due to above-zero temperature. But most cells are still alive and metabolizing very slowly at 10C. Viaspan, RPS-2 and other organ preservation solutions are designed to keep tissues alive for extended periods at near-zero temperatures certainly for the time required for closed-circuit perfusion. Ramping (slowly increasing concentration) of cryoprotectant should be done in such a way that the ion and mannitol or lactobionate concentration remains unchanged in the perfusate. Ramping is not an osmotically neutral process, however, because cryoprotectant is expected to dehydrate tissues.

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Perfusion & Diffusion in Cryonics Protocol - BEN BEST

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What about Eugenics and Planned Parenthood? | Answers in Genesis

Posted: at 4:44 pm

Life is preciousno matter how short or how impaired that life may be.

In 1915 a baby boy was born to Anna Bollinger. The baby had obvious deformities, and medical doctor Harry Haiselden decided the baby was not worth saving.1 The baby was denied treatment and died. The story became national news and the cruelty of eugenic practices became public knowledge.

The year 1915 seems far removed from our modern times, but the concept of eugenics is alive and well. In 2005, two doctors from the Netherlands published The Groningen ProtocolEuthanasia in Severely Ill Newborns.2 This protocol was published to help doctors decide whether or not a newborn should be actively killed based on the newborns disease and perceived quality of life.3

In this chapter we will explore historical and modern perspectives of eugenics, how Planned Parenthood has played a role in furthering the cause of eugenics in the past and present, and what the proper biblical perspective on these issues should be.

The term eugenics was first coined in 1883 by Francis Galton, father of eugenics and cousin of Charles Darwin. The term comes from the Greek roots eu (good) and genics (in birth) to communicate the idea of being well-born.

The ultimate goal of eugenics was to create a superior race of humans.4 Many adherents believed in evolution by natural selection, but that natural selection was moving too slowly in favoring the best and eliminating the worst.5 They also believed that charity in the form of taking care of the poor and sick was prohibiting natural selection from working properly and thus the need to intervene with artificial selection.6

Artificial selection was accomplished through two types of eugenicspositive and negative. Positive eugenics focused on increasing the fit through promoting marriages among the well-born and promoting those fit couples to have multiple children. Negative eugenics focused on decreasing the number of the unfit through prohibiting birth (birth control and sterilization) and segregation (e.g., institutionalization of the unfit, marriage restriction laws, and immigration restriction).

Although many people associate eugenics with the late 1800s and early 1900s, it is an ancient idea that was in practice long before it was called eugenics. The Law of the Twelve Tables (449 B.C.), which served as the foundation of Roman Law, states Cito necatus insignis ad deformitatem puer esto, which means, An obviously deformed child must be put to death.7 Both Plato and Aristotle supported this practice8 and it was not uncommon for infants to be exposed or left outside the home for a period of time to determine if they were fit enough to survive. The Romans wanted only the most fit for their future warriors.

Francis Galton, Darwins cousin, promoted eugenic beliefs.

Francis Galton, upon reading his cousin Charless book Origin of Species, 9 decided to apply the mechanisms of natural and artificial selection to man. He stated, Could not the undesirables be got rid of and the desirables multiplied?10 Galton promoted the ideas that human intelligence and other hard-to-measure traits such as behaviors were greatly influenced by heredity (not the environment, which was the popular mindset of the day).11 He advocated for a program of positive eugenics. His book Hereditary Genius (1869) was well liked by Charles12 and had a great influence on the ideas presented in his book Descent of Man (1871).13

In the early 1900s the eugenics movement became well established in the United States. The movement was well-funded by men like Carnegie, Rockefeller, and Kellogg. Eugenic societies, conferences, research institutions, and journals gave a faade of real science to the study of eugenics. This was further promoted by eugenic departments and courses at the university level.

The American eugenics movement focused heavily on negative eugenics.14 Ten classes of social misfits were determined upon which programs of negative eugenics were applied.

All of these traits were thought to be inheritable.16 Ten percent of the American population was thought to fit into these broad, ill-defined categories (sometimes known as the submerged tenth).17 Many of those people were forcibly institutionalized in asylums for the feebleminded and epileptic. Although not stated in the list, those of races other than the Caucasian race would also, by the mere fact of ethnic background, be placed into one or more of these categories. Unfortunately, the eugenics movement in the United States heavily influenced Hitler and his scientists and, in return, many eugenicists and eugenic publications supported the horrifying practices of Hitlers Nazi regime. Negative eugenic practices were even sanctioned by the American government.

Logo of the Second International Congress of Eugenics, 1921

In 1907, Indiana enacted the first forced sterilization law. The law would be applied to mentally impaired patients, poorhouse residents, and prisoners.18 Over 30 states enacted sterilization laws, and between 60,000 and 70,000 people were forcibly sterilized between 1900 and 1970.19 Most forced sterilizations were performed after 1927. In 1927 the Supreme Court ruled in favor of the forced sterilization of Carrie Buck20 (in Buck v. Bell) with justice Oliver Wendell Holmes stating, It is better for all the world, if instead of waiting to execute degenerate offspring for crime ... society can prevent those who are manifestly unfit from continuing their kind. ... Three generations of imbeciles are enough.21

The Immigration Act of 1924 set quotas on the number of people allowed into the United States from other countries. Lawmakers were heavily influenced by scientific data presented to them by high-ranking members of the eugenics movement.22

These laws (which varied by state) were designed to keep the Caucasian race pure. The laws prohibited mixed race marriages (i.e., Negro and Caucasian) but also marriages with those considered defective (e.g., blind).

The Christian response to eugenics was mixed. The Christian apologist G.K. Chesterton condemned eugenics in his 1922 book Eugenics and Other Evils. He saw how eugenics was being used in Germany to support Nazi ideals.23

However, some pastors used their pulpits to promote eugenics. The American Eugenics Society sponsored a sermon contest in 1926. Of the five sermons I read online, all were filled with popular rhetoric from the eugenics movement with little scriptural support given for eugenics. The pastors seemed to have accepted the science of eugenics without analyzing it in light of the Bible.24 This is very similar to the modern situation in which many Christian pastors accept the science of evolution, promote the idea in their churches, and dont analyze the conflicts between evolution and Scripture.

Margaret Sanger, founder of Planned Parenthood, promoted birth control as a means of controlling the unfit in society.

The name most commonly associated with Planned Parenthood is that of its founder Margaret Sanger. Margaret was born in 1879, the 6th of 11 children in a poor family, in New York.25 She was initially quite committed to the Catholic faith but eventually became very cynical in part due to the influence of her free thinking father.26 Margaret married into money and eventually became an active member of the Socialist Party. She was attracted to the partys fight for womens suffrage, sexual liberation, feminism, and birth control.27 Sanger also became a fan of the concepts promoted by Thomas Malthus (who also heavily influenced C
harles Darwin in the development of the concept of evolution by natural selection). Malthus was concerned that the human population was growing too rapidly (especially the poor, diseased, and racially inferior) and would outgrow natural resources. The solution proposed by his followers, like Sanger, was to decrease and eliminate the inferior population through birth control (including sterilization and abortion).28 Sanger stated, The most merciful thing a large family can do to one of its infant members is to kill it.29

Sanger became one of the foremost champions of birth control and not just for the benign reason of helping poor women who could not afford large families, but also for the liberation of sexual desire and the new science of eugenics.30 In 1921 she organized the American Birth Control League. In 1922 she published the book The Pivot of Civilization which unashamedly called for the elimination of human weeds, for the cessation of charity, for the segregation of morons, misfits, and the maladjusted and for the sterilization of genetically inferior races. 31 Sanger stated:

Her magazine, The Birth Control Review, contained many articles authored by leading eugenicists of her day. Sanger openly endorsed the concepts and methods of race purification carried out by the Nazis.33 Sanger believed sex was an evolutionary force that should not be prohibited because of its ability to create genius.34 In 1942, the American Birth Control League became the Planned Parenthood Federation of America (PPFA).

Eugenics became associated with the horrors of the Nazi regime in the 1940s and so its popularity in the public arena began to fade. In addition, much of the so-called science of eugenics was shown to be false by increased knowledge in the field of genetics. It became almost laughable to think that the eugenic-defined trait of sense of humor (no pun intended!) could be associated with a particular gene and/or somehow quantified.

However, eugenic concepts and the eugenic ideals of PPFA didnt die. Edwin Black states, While human genetics was becoming established in America, eugenics did not die out. It became quiet and careful.35 The eugenic agenda today is not different in principle or goal but only in name and methods. Eugenicist Frederick Osborn in 1965 stated, The term medical genetics has taken the place of the term negative eugenics.36 Genetic databases filled with individual genetic identities could now generate precise family genetic profiles as opposed to the subjective determination of non-measurable traits by self or other family members stored on millions of index cards that filled eugenic institutions in the early 20th century. In recent years, many feared the adverse use of genetic identities and profiles when applying for jobs and insurance.37

James Watson, co-discoverer of the structure of DNA, stated in 2003, If you are really stupid, I would call that a disease. The lower 10 percent who really have difficulty, even in elementary school, whats the cause of it? A lot of people would like to say, Well, poverty, things like that, It probably isnt. So Id like to get rid of that, to help lower the 10 percent.38 The idea of the submerged tenth is still alive and well in the 21st century.

Preimplantation genetic diagnosis (PGD) allows parents who have embryos created for use in in vitro fertilization (IVF) to check for genetic disorders and chromosomal abnormalities before the embryos are implanted. The defective embryos are destroyed. PGD is also being used for sex selection (only babies of the desired sex are used for IVF), disability selection (e.g., deafness), and predisposition or late-onset disease selection (i.e., predispositions to cancer and late-onset diseases like Alzheimers).39 Embryos are destroyed if they are not the desired sex, will have a disability, or may have cancer or disease later in life. PPFA endorses prenatal diagnosis procedures and genetic counseling.40 Eugenic concepts of prohibiting the birth of the unfits is still popular in the 21st century.

Planned Parenthood still endorses many eugenic ideas. This should not be surprising as the PPFA website History and Successes page clearly states, Margaret Sanger, the founder of Planned Parenthood, is one of the movements great heroes. Sangers early efforts remain the hallmark of Planned Parenthoods mission. ...41 Sangers efforts advocated sterilization, abortion, and infanticide of defectives in the name of eugenics. Further indicative of the promotion of eugenics, PPFA endorses abortion of deformed babies:

Thus, those infants who are gravely deformed should have been permitted to be eliminated according to PPFA. According to the American Life League, in 2006 PPFA was directly responsible (through its clinics) for 289,750 abortions.43 Thus, PPFA was responsible for almost 25 percent of the abortions estimated to have occurred in the U.S. in 2006.44

PPFA also still advocates for sexual liberation by encouraging the concept that sex and sexual desire is part of a normal, healthy lifestyle.45 These concepts are in line with Sangers view of sex, which she wrote about in a letter to her 16-year-old granddaughter: Kissing, petting, and even intercourse are alright as long as they are sincere.46 Alan Guttmacher, former president of PPFA stated, We are merely walking down the path that Mrs. Sanger carved out for us.47 How true!

When we start with the truth of Gods Word, we see that eugenics and the ideas promoted by Planned Parenthood do not align with the Bible.

There is neither Jew nor Greek, there is neither slave nor free, there is neither male nor female; for you are all one in Christ Jesus (Galatians 3:28).

And He has made from one blood every nation of men to dwell on all the face of the earth (Acts 17: (26a)).

God doesnt care whether people have dark brown skin or light brown skin, whether they are deaf or have perfect hearing God does not show partiality.

Then God said, Let Us make man in Our image, according to Our likeness; let them have dominion over the fish of the sea, over the birds of the air, and over the cattle, over all the earth and over every creeping thing that creeps on the earth. So God created man in His own image; in the image of God He created him; male and female He created them (Genesis 1:2627).

For You formed my inward parts; You covered me in my mothers womb. I will praise You, for I am fearfully and wonderfully made; Marvelous are Your works, And that my soul knows very well. My frame was not hidden from You, When I was made in secret, And skillfully wrought in the lowest parts of the earth. Your eyes saw my substance, being yet unformed. And in Your book they all were written, The days fashioned for me, When as yet there were none of them (Psalm 139:1316).

For God so loved the world that He gave His only begotten Son, that whoever believes in Him should not perish but have everlasting life (John 3:16).

God created each of us individually and we are His image-bearers on earth. He loved us so much that He sent His Son Jesus to die for us so that we might have eternal life.

You shall neither mistreat a stranger nor oppress him, for you were strangers in the land of Egypt. You shall not afflict any widow or fatherless child. If you afflict them in any way, and they cry at all to Me, I will surely hear their cry (Exodus 22:2123).

Then the King will say to those on His right hand, Come, you blessed of My Father, inherit the kingdom prepared for you from the foundation of the world: for I
was hungry and you gave Me food; I was thirsty and you gave Me drink; I was a stranger and you took Me in; I was naked and you clothed Me; I was sick and you visited Me; I was in prison and you came to Me (Matthew 25:3436).

God commands us to care for people no matter what their affliction.

My friends John and Tina were told after 19 years of marriage that they were going to have a baby.48 They were very excited and then the news came that the baby might have a chromosomal abnormality. Tina shared with me:

John said:

As difficult as Edens death was, we cherish our time with her. My heart breaks for those who lose their child before birth due to miscarriage or abortion. They have missed out on a marvelous experience with a new life.

The seven days we had with Eden were more glorious than I can describe. I will hold on to those precious memories for the rest of my life.50

Life is preciousno matter how short or how impaired that life may be. Contrary to the ideas supported by eugenics and Planned Parenthood, all human life has value because it comes from the Life Giver.

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William J. Bryans Fight against Eugenics and Racism …

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It is commonly believed that the Scopes trial was about the propriety of banning the teaching of evolution pushed by ignorant persons for religious reasons. In fact, not just human evolution but racism were the major concerns. This fact is well documented, and a review of the books used to teach evolution in the public schools at the time shows that they were blatantly racist. This fact is critical in understanding the concerns of those supporting the Butler act law, which was the focus of the trial.

Almost 90 years ago the trial of the century, the now-infamous Scopes evolution trial, occurred in Dayton, Tennessee (Lienesch 2007). The textbook involved, titled A Civic Biology (1914), was mandated by the state of Tennessee and many other states. For nearly a decade Hunters book was the most widely used high school science textbook in the nation. It was endorsed by many distinguished professors, including those at both Brown and Columbia Universities (Larson 1997). In 1919 the Tennessee Textbook Commission selected the Hunter book as the biology text for use in every one of its public schools.

The state of Tennessee did not have any issues with the bulk of the text, most of which covered basic information about earths plants and animals. Then, in March of 1925, the Tennessee Legislature passed the following law:

The statute was aimed at teaching the evolutionary origins of human beings (the Divine Creation of man), not the origin of the rest of life or even the origin of life. The law was intended to allow parents the right to instruct their children in matters of the origin of humans, human nature, and the destiny of humans. Because the law did not openly conflict with any section in A Civic Biology, which did not openly teach human evolution, the text remained in use throughout the state. Harvard law professor Alan Dershowitz correctly noted that those actively advocating evolution in 1925 included racists, militarists, and nationalists, who used evolution to push some pretty horrible programs, including forced sterilization (1990, p. 2). Those who wanted to prevent the immigration into America of persons judged by eugenists then as unfit and inferior, or of inferior racial stock, worked to pass the so-called Jim Crow laws. They rationalized their agenda on the grounds that blacks, Jews and others were racially inferior and would interbreed with the superior races, causing deterioration of the superior white race (Dershowitz 1990, p. 2). Dershowitz added that the eugenics movement took its impetus from Darwins theory of natural selection, explaining that German militarism

Darwin explained in detail the process of how selection functioned and the importance of death and war in advancing evolution. He stressed how all-important, in the never-ceasing wars of savages, fidelity and courage were to evolution, adding that a nation with superior qualities, those selected by natural selection, would have an evolutionary advantage that would enable them to destroy the weaker races (Darwin 1871, p. 162). This process of conflict was critical for evolution, and when natural selection that resulted from conflictsuch as from warceases, evolution also ceases. Hitler and other dictators repeatedly stressed this pointHitler in his bible Mein Kampf, and Marx, Engles, Lennin, Mao, and Stalin in their voluminous writings (Bergman 2012).

The law was supported by the famous Christian attorney, William J. Bryan, and opposed by the well-known agnostic attorney, University of Michigan trained Clarence Darrow. At issue in the 1925 trial were certain chapters on evolution and eugenics in a biology text by George W. Hunter. A major concern of attorney William J. Bryan was the degradation of humans by evolution and the influence of evolution on war and national conflicts. He wrote that the Darwinian theory teaches mankind reached his present perfection by the operation of the law of hatethe merciless law by which the strong crowd out and kill off the weak (quoted in Larson 2003, p. 252).

One book that influenced Bryan to draw this conclusion about the doctrine of evolution was written by American biologist Vernon Kellogg, who documented the importance of Darwinism in causing War World I (Kellogg 1917). The Hunter text perfectly illustrated Bryans concern because it was laced with the racism of the day (Larson 1997, p. 23). Its discussion of eugenics included such scarlet passages as the following openly racist claim:

Hunter also wrote that, if we can improve domesticated animals by breeding then future generations of men and women on the earth can also be improved by applying to them the laws of selection taught by Darwin. Hunter stressed that this is no small concern because nothing less than the improvement of the future race is at stake (1914, p. 261). Hunter then, under the subheading Eugenics, which made it clear what type of improvement programs he was referring to, applied the animal breeding research to humans:

When defending his eugenics program, Hunter incorrectly concluded that Tuberculosis (TB) is a genetic diseaseTB is actually caused by bacteria pathogens. Furthermore, the main causes of both epilepsy and feeble-mindedness are pathogens, trauma, and genetic damage occurring in the womb due to such conditions as genetic non-disjunction, not heredity as Hunter claimed. Hunter then wrote that research had been completed on many different families in America,

One now infamous case that Hunter cited was the Kallikak family that

Both of the Jukes and Kallikak family studies have now been thoroughly debunked by a reevaluation of the data and cases used to support the studies original conclusions (Smith 1985). The study is fatally flawed because it implied that the source of both the so-called bad as well as the good genes was from the female: the man bore all good progeny from the Quaker girl, and all bad progeny from the putative feeble-minded girl.

These irresponsible studies were the product of a powerful ideaDarwinismand they created a social myth that Hunter did much to spread throughout the Western world (Smith 1985, p. 193). The Kallikak family study was even translated into German in 1914, and the full text appeared in the German academic journal Friedrich Manns Pedagogishes Magazin. As a result, the Kallikak study also had a significant impact on Nazi Germanys racist policies that ended in the Holocaust.

One example was the infamous July 14 1933, sterilization law that began the murder of millions of inferior persons (Smith 1985, pp. 161162). Hitler used the same reasoning that Hunter used to justify his eugenic programs. For example, under the subheading Parasitism and its Cost to Society Hunter wrote that hundreds of families, such as the Kallikak family,

Hunter then quotes the now-notorious American eugenicist Charles Davenport (using the expression that Hitler later made famous: blood tells), writing eugenics has documented the belief that families which produce brilliant men and women did so because they received good genes from their ancestors. The text then used an example lifted from Davenports Heredity in Relation to Eugenics to illustrate the claim that greatness is due largely to genes (1914, p. 263). The story is about Elizabeth Tuttle, a women of strong will, and of extreme intellectual vigor who married Richard Edwards, a man of high repute and great erudition. This union produced Jonathan Edwards

No mention was made of the critical factor that social influence and privilege had in the success of this family. Genetics was the only factor given (Smith 1985). Olasky and Perry wrote that Hunters view of e
ugenics, widely accepted early in the twentieth century, was a common deduction drawn from and associated with Darwinian theory (2005, p. 70). They added that Hunter explained Darwinian evolution in only five pages, then moved on to the meat of the book, namely the section on

Hunter openly advocated the infamous solution, negative genetics, to what he saw as the mental illness and crime problem, genetically inferior persons. The reasoning was if these

Many Tennessee taxpayers, especially those of African American background, objected to the implications of the whole evolution doctrine that were made explicit in the very science text required by their state. Even prior to the 1925 Tennessee law, so great was the outcry against these passages in many other states that the publisher, American Book Company, had them rewritten (Tennessee used the original 1914 edition until 1926). Even the title of the book, Civic Biology, implied eugenics because the text taught that it is our civic duty to apply eugenics to achieve racial improvement.

Soon after the Tennessee anti-evolution law was passed, the American Civil Liberties Union began advertising for volunteers to challenge the law in court. The city of Dayton saw this as an opportunity to attract both attention and tourism. The local politicians then urged a new young football coach and math teacher, John Scopes, who once substituted for a biology teacher for a few days, to claim that he had violated the law during his short substitute teaching stint.

Prominent scientists from major universities soon flocked to Dayton to challenge the right of the state to regulate the teaching of human evolution and eugenics in public schools. A critical point is that these expert witnesses never once distanced themselves from the many inflammatory racist passages in A Civic Biology. Some of them were active supporters of the eugenics movement, as was Hunters text. Even after the abuses of Darwinian eugenics by the Nazis in the 1930s became common knowledge, some academics still approved the eugenic passages in this once-required public high school biology textbook.

Among the first persons to awaken to the racism lurking quite undisguised in these passages had been the left-leaning Democratic presidential candidate, William Jennings Bryan. Mr. Bryan stood at the forefront of the most progressive victories in his time: Womens suffrage, the direct election of senators, the graduated income tax, among others (Gould 1991, p. 417). His nickname since his first presidential candidacy (1896) was The Great Commoner, and Bryan believed his battle against evolution was an extension of both his populist support and his life work (Gould 1991, p. 419).

Historian Michael Kazin expatiates on Bryans attachments both to Thomas Jefferson and to the type of rural yeomen on whom Jefferson had pinned his moral hopes for the American Republic (2006). Although Bryan harbored doubts on the subject of evolution, his objections to teaching human evolution went far beyond his concerns about a scientific theory (Gilbert 1997 p. 25). A major concern of Bryan was that Darwinism had been used to justify the German war machine and that the survival-of-the-fittest philosophy had been translated into the might-makes-right ethos that had engulfed Germany and threatened to spread to other countries (Gilbert 1997 p. 31).

Bryan, a life-long opponent of solving national problems by war, was fearful that other nations would soon emulate Germany by using the martial view of Darwinism [that] had been invoked by most German intellectuals and military leaders as a justification for war and future domination (Gould 1991, pp. 421422). Bryan even resigned as Secretary of State in President Wilsons cabinet in protest of Americas entry into World War I.

Bryan pointed out several implications that many professors of his day were drawing from Darwins theory, included not only eugenics, but also the nihilistic morals of Nietzsche as elucidated in Darrows brief about the University of Chicago in the Leopold-Loeb murder case, and the moral obligation of superior races, such as the Germans in World War I, to overpower the weak races (e.g., the Belgians) for the advantage of the superior races future welfare. Bryan had been awakened to this last concern by reading a book by the well-known Stanford University biologist Vernon L. Kellogg (1917) that related his conversations with the German General Staff in Belgium in 1914.

African Americans were especially active in opposing evolution because Darwinism was a major force that supported racism against Negroes. The African American responses to Darwinism

Professor Moran added that African Americans living in both the Southern and Northern states openly expressed

Furthermore,

He added that

Using Darwinism to defend the coercive eugenics that was then being taught in American schools from Hunters bookand promoted by academiais now seen as repulsive by both most scholars and most Americans. Bryan turned out to be right on this point, while the promoters of eugenics as a corollary of human evolution were embarrassingly wrong. Bryan was right to object to Hunters text because its interpretation of science was wrong, and evolutionists were wrong to coercively impose their Darwinian eugenics philosophy and racism on public school students. The fact is, Bryan had identified something deeply troubling in the Scopes caseand that the fault does lie partly with scientists and their acolytes (Gould 1991, p. 423).

Bryan was also very concerned about the effects of Darwins racism teachings, such as the following passage from The Descent of Man: With savages, the weak in body or mind are soon eliminated (Darwin 1871, p. 168). Bryan made his concerns about the dignity of humankind very clear in the presentation that he gave to the court at the Scopes trial:

Bryan also noted that Darwins hostility to the use of vaccinations existed

Bryan then quoted Wiggam, a best-selling author in 1925, who wrote that

In his defense of accused murderers Loeb and Leopold, Darrow acknowledged the influence of Darwin on his clients. In his appeal to the court, Darrow wrote that Loeb became enamored of the philosophy of Nietzsche, a writer

In a chapter titled Monkeys and Mothers, Moran discusses gender and the anti-evolution impulse, concluding that, during the debate over the Butler anti-evolution act, the Tennessee State Senate Speaker

In addition, letters to

Moran concluded that the

One reason postulated by Moran for the opposition to Darwinism by women was because American women

Another reason he gave for womens support of anti-evolution was they were already secure

This concern of women was also over the harm that they felt Darwinism caused to their family.

Darrow added that one book Nietzsche wrote, titled Beyond Good and Evil, contained a criticism of all moral codes, and actually argued that the

These were exactly Bryans concerns as he documented in his booklet titled the Last Message (1975). Bryan was very concerned about the fact that an increasing number of students were attending high school and, Bryan believed, that Darwinism made man too much the product of essentially a material Godless process that invited his degradation through eugenics, too much a competitor in a struggle for survival that justified rapacious business relations and war between nations (Kevles 2007, p. x).

Bryans objections to evolution were openly related to Darwins writings about eugenics and i
ts implications for human rights, human dignity, and humanity as a whole. In short, he focused public attention on the social implications of Darwinism (Larson 2003, p. 250). Bryan was especially concerned about defending the weak against the assaults of the strong and powerful, a fact that resulted in his being labeled The Great Commoner. Bryan, as a political progressive, was very concerned about the

As a result, due to his progressive political instinct of seeking legislative solutions to social problems, Bryan campaigned for restrictions against teaching the Darwinian theory of human evolution in public schools (Larson 2007, p. 68). These many well-documented facts of history are often forgotten or ignored when Bryans role in the Scopes trial is reviewed (Gould 1981, p. 1987).

The most common claim is Darrow scored a triumph for academic freedom after John Scopes was accused of violating a Tennessee law that prohibited the teaching of evolution (Farrell 2011, p. 111). This background is imperative to understand why the trial occurred and the implications of evolution both then and today. Last, this review shows how totally erroneous the common claims are about the Scopes Trial, such as those presented in the film Inherit the Wind.

I wish to thank John UpChurch, Jody Allen, RN, Clifford Lillo, M.S., and Mary-Ann Stewart, M.S., for their comments on an earlier draft of this paper.

Bergman, Jerry. 2012. Hitler and the Nazis Darwinian Worldview: How the Nazis Eugenic Crusade for a Superior Race Caused the Greatest Holocaust in World History. Kitchener, Ontario, Canada: Joshua Press.

Bryan, William Jennings. 1975. The Last Message of William Jennings Bryan. (A Reprint Commemorating the Fiftieth Anniversary of the Scopes Evolution Trial, July 1021, 1925). Dayton, Tennessee: Bryan College.

Comfort, Nathaniel, ed. 2007. The Pandas Black Box: The Intelligent Design Controversy. Baltimore, Maryland: Johns Hopkins University Press.

Darwin, Charles. 1871. Descent of Man. London: John Murray.

Dershowitz, Alan (introduction). 1990. The Scopes Trial. Birmingham, Alabama: The Gryphon Press, Notable Trials Library Series.

Farrell, John. 2011. Darrow in the Dock. Smithsonian 42, no. 8: 98111.

Gould, Stephen Jay. 1981. A Visit to Dayton: The Site Remains a Pleasant Sleepy Town, but to the Bestial Cause of the Scopes Trial Stirs Again. Natural History 90, no. 10: 818.

Gould, Stephen Jay. 1991. Bully for Brontosaurus: Reflections in Natural History. New York: W.W. Norton and Company. Chapter 28: William Jennings Bryans Last Campaign, pp. 416431, and Chapter 29: An Essay on a Pig Roast, pp. 432447.

Gould, Stephen Jay. 1987. William Jennings Bryans Last Campaign: Scientists and Their Acolytes are Partly to Blame for the Lengthy and Bitter Struggle Against Creationism. Natural History 96, no. 11:1626.

Gilbert, James. 1997. Redeeming Culture: American Religion in an Age of Science. Chicago: The University of Chicago Press.

Ginger, Ray. 1974. Six Days or Forever? Tennessee v. John Thomas Scopes. New York: Oxford University Press.

Hunter, George. 1914. A Civic Biology. New York: American Book Company.

Kazin, Michael. 2006. A Godly Hero: The Life of William Jennings Bryan. New York: Alfred A. Knopf.

Kellogg, Vernon. 1917. Headquarters Nights: A Record of Conversations and Experiences at the Headquarters of the German Army in France and Belgium. Boston: Atlantic Monthly Press.

Kevles, Daniel. 2007. Foreword in The Panda's Black Box: Opening Up the Intelligent Design Controversy. Nathaniel Comfort, Ed., Baltimore, Maryland: Johns Hopkins University Press.

Larson, Edward John. 1997. Summer for the Gods: The Scopes Trial and Americas Continuing Debate over Science and Religion. New York: Basic Books.

Larson, Edward John. 2003. The Scopes Trial in History and Legend in When Science & Christianity Meet. Lindberg and Numbers, Ed., Chicago: The University of Chicago Press.

Larson, Edward John. 2007. The Classroom Controversy: A History Over Teaching Evolution in The Pandas Black Box: Opening up the Intelligent Design Controversy. Nathaniel Comfort, Ed., Baltimore, Maryland: Johns Hopkins University Press.

Lienesch, Michael. 2007. In the Beginning: Fundamentalism, the Scopes Trial, and the Making of the Antievolution Movement. Chapel Hill, North Carolina: The University of North Carolina Press.

McKernan, Maureen. 1924. The Amazing Crime and Trial of Leopold and Loeb. Chicago: The Plymouth Court Press.

Moran, Jeffrey P. 2012. American Genesis: The Evolution Controversies from Scopes to Creation Science. Oxford, New York: Oxford University Press.

Olasky, Marvin and John Perry. 2005. Monkey Business: The True Story of the Scopes Trial. Nashville, Tennessee: Broadman and Holman Publishing Group.

Smith, J. David. 1985. Minds Made Feeble: Myth and Legacy of the Kallikaks. Rockville, Maryland: Aspen.

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