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Monthly Archives: June 2016
eugenics | genetics | Britannica.com
Posted: June 21, 2016 at 6:38 am
Eugenics, the selection of desired heritable characteristics in order to improve future generations, typically in reference to humans. The term eugenics was coined in 1883 by the British explorer and natural scientist Francis Galton, who, influenced by Charles Darwins theory of natural selection, advocated a system that would allow the more suitable races or strains of blood a better chance of prevailing speedily over the less suitable. Social Darwinism, the popular theory in the late 19th century that life for humans in society was ruled by survival of the fittest, helped advance eugenics into serious scientific study in the early 1900s. By World War I, many scientific authorities and political leaders supported eugenics. However, it ultimately failed as a science in the 1930s and 40s, when the assumptions of eugenicists became heavily criticized and the Nazis used eugenics to support the extermination of entire races.
Galton, Sir FrancisCourtesy of The National Portrait Gallery, LondonAlthough eugenics as understood today dates from the late 19th century, efforts to select matings in order to secure offspring with desirable traits date from ancient times. Platos Republic (c. 378 bce) depicts a society where efforts are undertaken to improve human beings through selective breeding. Later, Italian philosopher and poet Tommaso Campanella, in City of the Sun (1623), described a utopian community in which only the socially elite are allowed to procreate. Galton, in Hereditary Genius (1869), proposed that a system of arranged marriages between men of distinction and women of wealth would eventually produce a gifted race. In 1865, the basic laws of heredity were discovered by the father of modern genetics, Gregor Mendel. His experiments with peas demonstrated that each physical trait was the result of a combination of two units (now known as genes) and could be passed from one generation to another. However, his work was largely ignored until its rediscovery in 1900. This fundamental knowledge of heredity provided eugenicistsincluding Galton, who influenced his cousin Charles Darwinwith scientific evidence to support the improvement of humans through selective breeding.
The advancement of eugenics was concurrent with an increasing appreciation of Charles Darwins account for change or evolution within societywhat contemporaries referred to as Social Darwinism. Darwin had concluded his explanations of evolution by arguing that the greatest step humans could make in their own history would occur when they realized that they were not completely guided by instinct. Rather, humans, through selective reproduction, had the ability to control their own future evolution. A language pertaining to reproduction and eugenics developed, leading to terms such as positive eugenics, defined as promoting the proliferation of good stock, and negative eugenics, defined as prohibiting marriage and breeding between defective stock. For eugenicists, nature was far more contributory than nurture in shaping humanity.
During the early 1900s, eugenics became a serious scientific study pursued by both biologists and social scientists. They sought to determine the extent to which human characteristics of social importance were inherited. Among their greatest concerns were the predictability of intelligence and certain deviant behaviours. Eugenics, however, was not confined to scientific laboratories and academic institutions. It began to pervade cultural thought around the globe, including the Scandinavian countries, most other European countries, North America, Latin America, Japan, China, and Russia. In the United States, the eugenics movement began during the Progressive Era and remained active through 1940. It gained considerable support from leading scientific authorities such as zoologist Charles B. Davenport, plant geneticist Edward M. East, and geneticist and Nobel Prize laureate Hermann J. Muller. Political leaders in favour of eugenics included U.S. President Theodore Roosevelt, Secretary of State Elihu Root, and Associate Justice of the Supreme Court John Marshall Harlan. Internationally, there were many individuals whose work supported eugenic aims, including British scientists J.B.S. Haldane and Julian Huxley and Russian scientists Nikolay K. Koltsov and Yury A. Filipchenko.
Pearson, KarlCourtesy of Professor D.V. Lindley; photograph, J.R. Freeman & Co. Ltd.Galton had endowed a research fellowship in eugenics in 1904 and, in his will, provided funds for a chair of eugenics at University College, London. The fellowship and later the chair were occupied by Karl Pearson, a brilliant mathematician who helped to create the science of biometry, the statistical aspects of biology. Pearson was a controversial figure who believed that environment had little to do with the development of mental or emotional qualities. He felt that the high birth rate of the poor was a threat to civilization and that the higher races must supplant the lower. His views gave countenance to those who believed in racial and class superiority. Thus, Pearson shares the blame for the discredit later brought on eugenics.
In the United States, the Eugenics Record Office (ERO) was opened at Cold Spring Harbor, Long Island, N.Y., in 1910 with financial support from the legacy of railroad magnate Edward Henry Harriman. Whereas ERO efforts were officially overseen by Charles B. Davenport, director of the Station for Experimental Study of Evolution (one of the biology research stations at Cold Spring Harbor), ERO activities were directly superintended by Harry H. Laughlin, a professor from Kirksville, Mo. The ERO was organized around a series of missions. These missions included serving as the national repository and clearinghouse for eugenics information, compiling an index of traits in American families, training field-workers to gather data throughout the United States, supporting investigations into the inheritance patterns of particular human traits and diseases, advising on the eugenic fitness of proposed marriages, and communicating all eugenic findings through a series of publications. To accomplish these goals, further funding was secured from the Carnegie Institution of Washington, John D. Rockefeller, Jr., the Battle Creek Race Betterment Foundation, and the Human Betterment Foundation.
Prior to the founding of the ERO, eugenics work in the United States was overseen by a standing committee of the American Breeders Association (eugenics section established in 1906), chaired by ichthyologist and Stanford University president David Starr Jordan. Research from around the globe was featured at three international congresses, held in 1912, 1921, and 1932. In addition, eugenics education was monitored in Britain by the English Eugenics Society (founded by Galton in 1907 as the Eugenics Education Society) and in the United States by the American Eugenics Society.
Following World War I, the United States gained status as a world power. A concomitant fear arose that if the healthy stock of the American people became diluted with socially undesirable traits, the countrys political and economic strength would begin to crumble. The maintenance of world peace by fostering democracy, capitalism, and, at times, eugenics-based schemes was central to the activities of the Internationalists, a group of prominent American leaders in business, education, publishing, and government. One core member of this group, the New York lawyer Madison Grant, aroused considerable pro-eugenic interest through his best-selling book The Passing of the Great Race (1916). Beginning in 1920, a series of congressional hearings was held to identify problems that immigrants were causing the United States. As the countrys eugenics expert, Harry Laughlin provided tabulations showing that certain immigrants, particularly those from Italy, Greece, and Eastern Europe, were significantly overrepresented in American prisons and institutions for the feebleminded. Further data were construed to suggest that these groups were contributing too many genetically and socially inferior people. Laughlins classification of these individuals included the feebleminded, the insane, the criminalistic, the epileptic, the inebriate, the diseasedincluding those with tuberculosis, leprosy, and syphilisthe blind, the deaf, the deformed, the dependent, chronic recipients of charity, paupers, and neer-do-wells. Racial overtones also pervaded much of the British and American eugenics literature. In 1923, Laughlin was sent by the U.S. secretary of labour as an immigration agent to Europe to investigate the chief emigrant-exporting nations. Laughlin sought to determine the feasibility of a plan whereby every prospective immigrant would be interviewed before embarking to the United States. He provided testimony before Congress that ultimately led to a new immigration law in 1924 that severely restricted the annual immigration of individuals from countries previously claimed to have contributed excessively to the dilution of American good stock.
Immigration control was but one method to control eugenically the reproductive stock of a country. Laughlin appeared at the centre of other U.S. efforts to provide eugenicists greater reproductive control over the nation. He approached state legislators with a model law to control the reproduction of institutionalized populations. By 1920, two years before the publication of Laughlins influential Eugenical Sterilization in the United States (1922), 3,200 individuals across the country were reported to have been involuntarily sterilized. That number tripled by 1929, and by 1938 more than 30,000 people were claimed to have met this fate. More than half of the states adopted Laughlins law, with California, Virginia, and Michigan leading the sterilization campaign. Laughlins efforts secured staunch judicial support in 1927. In the precedent-setting case of Buck v. Bell, Supreme Court Justice Oliver Wendell Holmes, Jr., upheld the Virginia statute and claimed, It is better for all the world, if instead of waiting to execute degenerate offspring for crime, or to let them starve for their imbecility, society can prevent those who are manifestly unfit from continuing their kind.
During the 1930s, eugenics gained considerable popular support across the United States. Hygiene courses in public schools and eugenics courses in colleges spread eugenic-minded values to many. A eugenics exhibit titled Pedigree-Study in Man was featured at the Chicago Worlds Fair in 193334. Consistent with the fairs Century of Progress theme, stations were organized around efforts to show how favourable traits in the human population could best be perpetuated. Contrasts were drawn between the emulative, presidential Roosevelt family and the degenerate Ishmael family (one of several pseudonymous family names used, the rationale for which was not given). By studying the passage of ancestral traits, fairgoers were urged to adopt the progressive view that responsible individuals should pursue marriage ever mindful of eugenics principles. Booths were set up at county and state fairs promoting fitter families contests, and medals were awarded to eugenically sound families. Drawing again upon long-standing eugenic practices in agriculture, popular eugenic advertisements claimed it was about time that humans received the same attention in the breeding of better babies that had been given to livestock and crops for centuries.
Antieugenics sentiment began to appear after 1910 and intensified during the 1930s. Most commonly it was based on religious grounds. For example, the 1930 papal encyclical Casti connubii condemned reproductive sterilization, though it did not specifically prohibit positive eugenic attempts to amplify the inheritance of beneficial traits. Many Protestant writings sought to reconcile age-old Christian warnings about the heritable sins of the father to pro-eugenic ideals. Indeed, most of the religion-based popular writings of the period supported positive means of improving the physical and moral makeup of humanity.
In the early 1930s, Nazi Germany adopted American measures to identify and selectively reduce the presence of those deemed to be socially inferior through involuntary sterilization. A rhetoric of positive eugenics in the building of a master race pervaded Rassenhygiene (racial hygiene) movements. When Germany extended its practices far beyond sterilization in efforts to eliminate the Jewish and other non-Aryan populations, the United States became increasingly concerned over its own support of eugenics. Many scientists, physicians, and political leaders began to denounce the work of the ERO publicly. After considerable reflection, the Carnegie Institution formally closed the ERO at the end of 1939.
During the aftermath of World War II, eugenics became stigmatized such that many individuals who had once hailed it as a science now spoke disparagingly of it as a failed pseudoscience. Eugenics was dropped from organization and publication names. In 1954, Britains Annals of Eugenics was renamed Annals of Human Genetics. In 1972, the American Eugenics Society adopted the less-offensive name Society for the Study of Social Biology. Its publication, once popularly known as the Eugenics Quarterly, had already been renamed Social Biology in 1969.
U.S. Senate hearings in 1973, chaired by Edward Kennedy, revealed that thousands of U.S. citizens had been sterilized under federally supported programs. The U.S. Department of Health, Education, and Welfare proposed guidelines encouraging each state to repeal their respective sterilization laws. Other countries, most notably China, continue to support eugenics-directed programs openly in order to ensure the genetic makeup of their future.
Despite the dropping of the term eugenics, eugenic ideas remain prevalent in many issues surrounding human reproduction. Medical genetics, a post-World War II medical specialty, encompasses a wide range of health concerns, from genetic screening and counseling to fetal gene manipulation and the treatment of adults suffering from hereditary disorders. Because certain diseases (e.g., hemophilia and Tay-Sachs disease) are now known to be genetically transmitted, many couples choose to undergo genetic screening, in which they learn the chances that their offspring have of being affected by some combination of their hereditary backgrounds. Couples at risk of passing on genetic defects may opt to remain childless or to adopt children. Furthermore, it is now possible to diagnose certain genetic defects in the unborn. Many couples choose to terminate a pregnancy that involves a genetically disabled offspring. These developments have reinforced the eugenic aim of identifying and eliminating undesirable genetic material. Counterbalancing this trend, however, has been medical progress that enables victims of many genetic diseases to live fairly normal lives. Direct manipulation of harmful genes is also being studied. If perfected, it could obviate eugenic arguments for restricting reproduction among those who carry harmful genes. Such conflicting innovations have complicated the controversy surrounding what many call the new eugenics. Moreover, suggestions for expanding eugenics programs, which range from the creation of sperm banks for the genetically superior to the potential cloning of human beings, have met with vigorous resistance from the public, which often views such programs as unwarranted interference with nature or as opportunities for abuse by authoritarian regimes.
Applications of the Human Genome Project are often referred to as Brave New World genetics or the new eugenics; however, the ethical, legal, and social implications of this international project are monitored much more closely than were early 20th-century eugenics programs. Applications also generally are more focused on the reduction of genetic diseases than on improving intelligence. Still, with or without the use of the term, many eugenics-related concerns are reemerging as a new group of individuals decide how to regulate the application of genetics science and technology. This gene-directed activity, in attempting to improve upon nature, may not be that distant from what Galton implied in 1909 when he described eugenics as the study of agencies, under social control, which may improve or impair future generations.
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Kissinger, Eugenics And Depopulation – Rense
Posted: at 6:38 am
Dr. Henry Kissinger, who wrote: "Depopulation should be the highest priority of U.S. foreign policy towards the Third World." Research on population control, preventing future births, is now being carried out secretly by biotech companies. Dr. Ignacio Chapela, a University of California microbiologist, discovered that wild corn in remote parts of Mexico is contaminated with lab altered DNA. That discovery made him a threat to the biotech industry. Chapela was denied tenure at UC Berkeley when he reported this to the scientific community, despite the embarrassing discovery that UC Chancellor Berdahl, who was denying him tenure, was getting large cash payments - $40,000 per year - from the LAM Research Corp. in Plano, Texas. Berdahl served as president of Texas A&M University before coming to Berkeley. During a presentation about his case, Chapela revealed that a spermicidal corn developed by a U.S. company is now being tested in Mexico. Males who unknowingly eat the corn produce non-viable sperm and are unable to reproduce. Depopulation, also known as eugenics, is quite another thing and was proposed under the Nazis during World War II. It is the deliberate killing off of large segments of living populations and was proposed for Third World countries under President Carter's administration by the National Security Council's Ad Hoc Group on Population Policy. National Security Memo 200, dated April 24, 1974, and titled "Implications of world wide population growth for U.S. security & overseas interests," says: "Dr. Henry Kissinger proposed in his memorandum to the NSC that "depopulation should be the highest priority of U.S. foreign policy towards the Third World." He quoted reasons of national security, and because `(t)he U.S. economy will require large and increasing amounts of minerals from abroad, especially from less-developed countries ... Wherever a lessening of population can increase the prospects for such stability, population policy becomes relevant to resources, supplies and to the economic interests of U.S. Depopulation policy became the top priority under the NSC agenda, Club of Rome and U.S. policymakers like Gen. Alexander Haig, Cyrus Vance, Ed Muskie and Kissinger. According to an NSC spokesman at the time, the United States shared the view of former World Bank President Robert McNamara that the "population crisis" is a greater threat to U.S. national security interests than nuclear annihilation.In 1975, Henry Kissinger established a policy-planning group in the U.S. State Department's Office of Population Affairs. The depopulation "GLOBAL 2000" document for President Jimmy Carter was prepared. It is no surprise that this policy was established under President Carter with help from Kissinger and Brzezinski - all with ties to David Rockefeller. The Bush family, the Harriman family - the Wall Street business partners of Bush in financing Hitler - and the Rockefeller family are the elite of the American eugenics movement. Even Prince Philip of Britain, a member of the Bilderberg Group, is in favor of depopulation: "If I were reincarnated I would wish to be returned to earth as a killer virus to lower human population levels" (Prince Philip Duke of Edinburgh, leader of the World Wildlife Fund, quoted in "Are You Ready for Our New Age Future?" Insiders Report, American Policy Center, December 1995). Secretary of Defense Donald Rumsfeld has been proposing, funding and building Bio-Weapons Level 3 and Level 4 labs at many places around the U.S. even on university campuses and in densely populated urban locations. In a Bio-Weapons Level 4 facility, a single bacteria or virus is lethal. Bio-Weapons Level 4 is the highest level legally allowed in the continental U.S. For what purpose are these labs being developed, and who will make the decisions on where bio-weapons created in these facilities will be used and on whom? More than 20 world-class microbiologists have been murdered since 2002, mostly in the U.S. and the UK. Nearly all were working on development of ethnic-specific bio-weapons (see Smart Dust, Roboflies &). Citizens around the U.S. are frantically filing lawsuits to stop these labs on campuses and in communities where they live. Despite the opposition of residents living near UC Davis, where a Bio-Weapons Level 4 lab was planned, it had the support of the towns mayor. She suddenly reversed her position after a monkey escaped from a high security primate facility on the campus where the bio-weapons lab was proposed. Residents claimed that if UC Davis could not keep monkeys from escaping from their cages, they certainly could not guarantee that a single virus or bacteria would not escape from a test tube. The AWOL monkey killed the project (see Smart Dust, Roboflies&). Population is a political problem. The extreme secrecy surrounding the takeover of nuclear weapons, NASA and the space program and the development of numerous bio-weapons labs is a threat to civil society, especially in the hands of the military and corporations. The fascist application of all three of these programs can be used to achieve established U.S. government depopulation policy goals, which may eliminate 2 billion of the worlds existing population through war, famine, disease and any other methods necessary. Two excellent examples of existing U.S. depopulation policy are, first, the long-term impact on the civilian population from Agent Orange in Vietnam, where the Rockefellers built oil refineries and aluminum plants during the Vietnam War. The second is the permanent contamination of the Middle East and Central Asia with depleted uranium, which, unfortunately, will destroy the genetic future of the populations living in those regions and will also have a global effect already reflected in increases in infant mortality reported in the U.S., Europe, and the UK. References Birth defects: The Tiny Victims of Desert Storm,Life photo-essay (1995), http://www.life.com /Life/essay/gulfwar/gulf01.html. Statement by Prince Philip Duke of Edinburgh, http://homepage.mac.com /kaaawa/iblog/C337802379/E1557478132/. Smart dust, roboflies, microbugs: UC is spying on youby Leuren Moret, San Francisco Bay View, Feb. 26, 2003, http://www.mindfully.org /Nucs/2003/Berkeley-Library-Classified22feb03.htm. San Francisco Bay View National Black Newspaper 4917 Third Street San Francisco California 94124 Phone: (415) 671-0789 Fax: (415) 671-0316 editor@sfbayview.co http://www.sfbayview.com /110304/ucregents110304.shtml
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Cloning Blues – TV Tropes
Posted: at 6:38 am
"I am a clone, I am not alone... If you had ever seen us you'd rejoice in your uniqueness And consider every weakness something special of your own" Robert Calvert (Hawkwind), "Spirit of the Age" In Speculative Fiction, being a clone absolutely sucks. It's enough to make a clone sing the blues. Though Real Life artificial clones have to start at conception and go through childhood all over again, and can even have phenotypes that vary from their parent, Speculative Fiction clones are like perfect meta-xerox copies of the cloned person. They are exactly like the target at the moment of cloning, (possibly excused by age acceleration) with all their forebearers' memories and skills, although their personalities can develop from there. As a result, many clones brood about how they're not "real," just hollow imitations of the original. The clones tend to deal with this rather badly. Some make desperate attempts to act different. Others go mad and try to murder the original to take their place. (Emphasis on "try" hardly any succeed.) If the clone is a main character, they will spend the whole show angsting about how they're the Tomato in the Mirror. Occasionally they will have powers just like the Artificial Human. This often just ups their feelings of alienation, though. But Fridge Logic kicks in and makes this Wangst when you realize that clones occur in Real Life all the time; they're called identical twins, and they generally don't have existential crises over it. That's for the lucky clones who are created properly. In many shows, cloning is an imprecise science, so there is a high probability that any clone will turn out to be an Evil Twin almost as high as the probability of creating an evil computer (Because everyone knows that Science Is Bad). Other unlucky clones will just have birth defects, Resurrection Sickness or be increasingly inexact duplicates. And that's for the clones who are just unlucky. The really unlucky clones have malevolent creators who can make custom clones grown in a vat, sometimes in bulk which are exact meta-xerox copies of the original except that they have fanatical loyalty to the creators. You can expect all that tinkering to make something Go Horribly Wrong, too. A clone like this is always considered highly expendable by their creator, except in rare cases where said Evilutionary Biologist has developed an attachment to it. Because of all this (or possibly as a cause of all this), clones get very little respect. Heroes who hesitate at killing intelligent life might still kill their evil clone. In the question of What Measure Is a Non-Human?, most clones rank somewhere between the Big Creepy-Crawlies and the Mecha-Mooks. Interestingly, on the question of What Measure Is a Non-Unique? the only clone that matters is the last one...provided the original is dead. This assumes the clone ever had a mind of its own, of course. Sometimes a clone is an Empty Shell without the original's soul, and exists only so that the creator can overwrite their mind and personality onto it in case of accident. In this case, it's more like coming Back from the Dead although if the clone has a mind of its own at the start, this is yet another reason its life sucks. And let's not debate how Our Souls Are Different, in which case clones (especially of the deceased) will be soulless abominations before God and nature. Some clones aren't biological clones at all they're robot doubles, or copies created by the good old transporter. These have more reason to be exact xerox copies but they get even less respect. Note that all instances of actual cloning in Real Life require a live animal of the same species with a womb to carry the cloned animal to term. Science fiction tends to ignore this requirement competely, which only enforces the Trope. Unrelated to Something Blues, and to cloning Proto Man (i.e. Blues). See also Scale of Scientific Sins and Creating Life. Closely related to Expendable Clone. Contrast with Clones Are People Too, where they do get to live their own lives. Warning: This trope is often introduced as a Plot Twist, so expect spoilers.
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"Are you an angel?" his voice is the sound of leaves brushing over a tombstone. This the awful question, because if he hadn't asked it, he would still love her. His eyes are so blue, so strange set into the roped scars on his head.
"I don't know," she says, and as soon as her voice sounds, she knows it is the wrong answer. The first time he asked, when she was five, she said she was whatever he wanted her to be. Her left arm had never mended right.
Celestia was ticked, let me tell you. I mean, just creating life like that, kind of a big deal. Didn't help that I was in the middle of a breakdown, you know, the usual 'am I real' kinda thing you read in sci-fi, but the gala went pretty good despite all that.
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Angier: "You have no idea how much courage it took to step into that machine every night, not knowing if I'd be the Prestige . . . or the man in the box."
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Carib: You're [Leia] a sophisticated woman, a politician and diplomat, fully accustomed to dealing with the whole spectrum of sentient beings. And you're good at it. Yet you, too, feel uncomfortable in our presence. Admit it.
Cordelia: Half my genes run through your body, and my selfish genome is heavily evolutionarily pre-programmed to look out for its copies. The other half is copied from the man I admire most in all the worlds. The artistic combination of the two, shall we say, arrests my attention.
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In the valley of silly clones, where the people turn to stone In the valley of silly clones, people made of styrofoam In the valley of silly clones, where the people die alone
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AyleeBot: According to the latest available galactic census data, blue-haired, Caucasian human males are now the largest single sapient ethnicity in the galaxy. You outnumber several entire sapient species.
McNinja: How'd it go? Did we do it?! Ben Franklin: You're one of the clones. Get in line. McNinja: Aw...
McNinja: So...you just cloned...a clone of me. But they...don't want to kill me? Clone: I am far too busy coming to terms with the existential dread of being a clone.
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Molecular Cloning
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Molecular Cloninghas served as the foundation of technical expertise in labs worldwide for 30 years. No other manual has been so popular, or so influential. Molecular Cloning, Fourth Edition, by the celebrated founding author Joe Sambrook and new co-author, the distinguished HHMI investigator Michael Green, preserves thehighly praised detail and clarity of previous editions and includes specific chapters and protocols commissioned for the book from expert practitioners at Yale, U Mass, Rockefeller University, Texas Tech, Cold Spring Harbor Laboratory, Washington University, and other leading institutions. The theoretical and historical underpinnings of techniques are prominent features of the presentation throughout, information that does much to help trouble-shoot experimental problems.
For the fourth edition of this classic work, the content has been entirely recast to include nucleic-acid based methods selected as the most widely used and valuable in molecular and cellular biology laboratories.
Corechapters from the third edition have been revised to feature current strategies and approaches to the preparation and cloning of nucleic acids, gene transfer, and expression analysis. They are augmented by 12 new chapters which show how DNA, RNA, and proteins should be prepared, evaluated, and manipulated, and how data generation and analysis can be handled.
The new content includes methods for studying interactions between cellular components, such as microarrays, next-generation sequencing technologies, RNA interference, and epigenetic analysis using DNA methylation techniques and chromatin immunoprecipitation. To make sense of the wealth of data produced by these techniques, a bioinformatics chapter describes the use of analytical tools for comparing sequences of genes and proteins and identifying common expression patterns among sets of genes.
Building on thirty years of trust, reliability, and authority, the fourth edition of Molecular Cloning is the new gold standardthe one indispensable molecular biology laboratory manual and reference source.
Highlights of the new edition:
Praise for the previous edition:
Any basic research laboratory using molecular biology techniques will benefit from having a copy on hand of the newly published Third Edition of Molecular Cloning: A Laboratory Manual...the first two editions of this book have been staples of molecular biology with a proven reputation for accuracy and thoroughness. The Scientist
In every kitchen there is at least one indispensable cookbook...Molecular Cloning: A Laboratory Manual fills the same niche in the laboratory (with) information to help both the inexperienced and the advanced user. (It) has once again established its primacy as the molecular laboratory manual and is likely to be found on lab benches...around the world. Trends in Neurosciences
Molecular Cloning: A Laboratory Manual has always been the laboratory mainstay for protocols and techniques. It has a pure-bred ancestry, and the new edition does not disappoint. (It) includes information panels at the end of each chapter that describe the principles behind the protocols.... The addition of this information extends Molecular Cloning from an essential laboratory resource into a new realm, one merging the previous prototype with a modern molecular monograph...the next generation of Molecular Cloning not only carries on the proud heritage of the first two editions but also admirably expands on that tradition to provide a truly essential laboratory manual. Trends in Microbiology
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Reasons Against Cloning – VIDEOS & ARTICLES
Posted: at 6:38 am
Written by Patrick Dixon
Futurist Keynote Speaker: Posts, Slides, Videos - What is Human Cloning? How to Clone. But Ethical?
Human cloning: who is cloning humans and arguments against cloning (2007)
How human clones are being made - for medical research. Arguments for and against human cloning research. Why some people want to clone themselves or even to clone the dead (and not just cloning pets).
Why investors are moving away from human cloning and why human cloning now looks a last-century way to fight disease (2007)
Should we ban human cloning? Arguments against cloning
An abnormal baby would be a nightmare come true. The technique is extremely risky right now. A particular worry is the possibility that the genetic material used from the adult will continue to age so that the genes in a newborn baby clone could be - say - 30 years old or more on the day of birth. Many attempts at animal cloning produced disfigured monsters with severe abnormalities. So that would mean creating cloned embryos, implanting them and destroying (presumably) those that look imperfect as they grow in the womb. However some abnormalities may not appear till after birth. A cloned cow recently died several weeks after birth with a huge abnormality of blood cell production. Dolly the Sheep died prematurely of severe lung disease in February 2003, and also suffered from arthritis at an unexpectedly early age - probably linked to the cloning process.
Even if a few cloned babies are born apparently normal we will have to wait up to 20 years to be sure they are not going to have problems later -for example growing old too fast. Every time a clone is made it is like throwing the dice and even a string of "healthy" clones being born would not change the likelihood that many clones born in future may have severe medical problems. And of course, that's just the ones born. What about all the disfigured and highly abnormal clones that either spontaneously aborted or were destroyed / terminated by scientists worried about the horrors they might be creating.
A child grows up knowing her mother is her sister, her grandmother is her mother. Her father is her brother-in-law. Every time her mother looks at her, she is seeing herself growing up. Unbearable emotional pressures on a teenager trying to establish his or her identity. What happens to a marriage when the "father" sees his wife's clone grow up into the exact replica (by appearance) of the beautiful 18 year old he fell in love with 35 years ago? A sexual relationship would of course be with his wife's twin, no incest involved technically.
Or maybe the child knows it is the twin of a dead brother or sister. What kind of pressures will he or she feel, knowing they were made as a direct replacement for another? It is a human experiment doomed to failure because the child will NOT be identical in every way, despite the hopes of the parents. One huge reason will be that the child will be brought up in a highly abnormal household: one where grief has been diverted into makeing a clone instead of adjusting to loss. The family environment will be totally different than that the other twin experienced. That itself will place great pressures on the emotional development of the child. You will not find a child psychiatrist in the world who could possibly say that there will not be very significant emotional risk to the cloned child as a result of these pressures.
What would Hitler have done with cloning technology if available in the 1940s? There are powerful leaders in every generation who will seek to abuse this technology for their own purposes. Going ahead with cloning technology makes this far more likely. You cannot have so-called therapeutic cloning without reproductive cloning because the technique to make cloned babies is the same as to make a cloned embryo to try to make replacement tissues. And at the speed at which biotech is accelerating there will soon be other ways to get such cells - adult stem cell technology. It is rather crude to create a complete embryonic identical twin embryo just to get hold of stem cells to make - say - nervous tissue. Much better to take cells from the adult and trigger them directly to regress to a more primitive form without the ethical issues raised by inserting a full adult set of genes into an unfertilised egg.
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Mind Uploading
Posted: at 6:37 am
Welcome
Minduploading.org is a collection of pages and articles designed to explore the concepts underlying mind uploading. The articles are intended to be a readable introduction to the basic technical and philosophical topics covering mind uploading and substrate-independent minds. The focus is on careful definitions of the common terms and what the implications are if mind uploading becomes possible.
Mind uploading is an ongoing area of active research, bringing together ideas from neuroscience, computer science, engineering, and philosophy. This site refers to a number of participants and researchers who are helping to make mind uploading possible.
Realistically, mind uploading likely lies many decades in the future, but the short-term offers the possibility of advanced neural prostheses that may benefit us.
Mind uploading is a popular term for a process by which the mind, a collection of memories, personality, and attributes of a specific individual, is transferred from its original biological brain to an artificial computational substrate. Alternative terms for mind uploading have appeared in fiction and non-fiction, such as mind transfer, mind downloading, off-loading, side-loading, and several others. They all refer to the same general concept of transferring the mind to a different substrate.
Once it is possible to move a mind from one substrate to another, it is then called a substrate-independent mind (SIM). The concept of SIM is inspired by the idea of designing software that can run on multiple computers with different hardware without needing to be rewritten. For example, Javas design principle write once, run everywhere makes it a platform independent system. In this context, substrate is a term referring to a generalized concept of any computational platform that is capable of universal computation.
We take the materialist position that the human mind is solely generated by the brain and is a function of neural states. Additionally, we assume that the neural states are computational processes and devices capable of universal computing are sufficient to generate the same kind of computational processes found in a brain.
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Virtual Reality – Virtual Reality
Posted: at 6:37 am
Virtual Reality
Welcome to Virtual Reality Society (VRS). A one-stop information and news resource for virtual reality and its related technologies. Here you will find a wide range of information on the exciting world of virtual reality, from comprehensive material for beginners to interesting and deep discussions of virtual realitys problems, implications and applications.
Our mission is to become the definitive source of virtual reality information and we constantly strive to achieve this goal. Be sure to bookmark us and check back regularly for new features and new sections on our site.
Virtual reality is essentially the use of technology to create the illusion of presence in an environment that isnt really there. It works by sending information to various senses, such as sight and hearing, that fool our brains into experiencing something virtual. The illusion is often completed by the presence of interactivity, in other words the virtual world responds in some way to your presence.
Of course, generating such virtual worlds by technological means is quite a complex process and requires advanced computer hardware and software to accomplish, not to mention the complexity of peripheral devices that perform virtual reality specific functions themselves.
Its this historical cost of virtual reality that has confined its application to areas where it is either infeasible to simulate something in another way or the danger of doing so would be too great. Aviation and medicine, for example, have made use of virtual reality to allow pilots and surgeons to train in their respective professions in a highly realistic manner without risking life, limb or infrastructure.
There have been attempts to translate these high-end virtual reality technologies to the consumer space before, but the technological limitations of the day meant that not only were these products not particularly good, but many were actively unpleasant to use. Issues such as motion sickness brought on by slow and laggy visuals, for example, would be enough to put anyone off from trying the technology a second time.
Today however, thanks to the march of technological innovation, virtual reality is set to undergo a renaissance in the consumer world. Virtual Reality (VR) and its close cousin Augmented Reality (AR) are going to become ever more common features in daily life, just like smartphones and the internet. Youll likely find that no matter the area you work in, virtual reality will have some impact on it in the near to medium term. So, dont get caught out by the next big consumer technology revolution! Join us in exploring the state of the art as well as the past and future of virtual reality.
We have series of articles about the various applications of this technology and the equipment used, for example, VR glasses (or goggles as they are sometimes called). This is where you can find out more about the two types of virtual environments:
Both of these result in very different types of experiences.
A virtual environment needs to place the user at its centre and ensure that he or she has a productive experience which they are likely to repeat. But a common problem with virtual reality systems is motion sickness which is caused by poor ergonomics and a lack of awareness of the physical needs of the user. This, as one of the disadvantages of virtual reality, is something which needs to be addressed.
There are many other sections to discover here at VRS, so feel free to explore every part of the site. If you have any questions or comments you can find us on the contact page.
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Immortality – The Atheist; scourge of religion and scammers
Posted: at 6:37 am
As of January 2016, the site has been accessed hundreds of thousands of times by people searching for facts about fuel-saving scams and psychics' claims from Sensing Murder in particular. We have added another fuel scam - Fuel360. Read all about it here.
We have had feedback from people all over the world who have learned that fuel-saving devices don't work, saving them thousands of dollars in wasted payments to scammers.
Have a look around, and if you want to ask a question, or get us to investigate a scam, email alan@immortality.co.nz and we'll get right on the case!
While I love to take on all scams and blatant bullshit, I am The Atheist, and my prime target is the stupidity, delusion and bullshit that make up the world's religions.
In the year 2016, when science can attempt to create a mini "big bang" at CERN, can replace almost every organ in the human body with a high degree of success, and can cure cancers that were deadly only a generation ago, we live in times where rationality and reason should take precedence over everything else.
Alas, that is not so, and as time marches on, religion is strengthening its hold on more and more people.
Many atheists rejoice in censuses showing decline in the "religion" identifier question, but I believe that is false hope, as the number of people who attend church has risen dramatically over the past decade. 40 years ago, almost no people aged between 18 and 40 went to church, nowadays, they have overflowing carparks.
The impact of these increased numbers - and therefore money and power - is easy to see if you know where to look. From Family First to the Maxim Institute, religions have set up fronts as "family-focused" organisations as pressure groups, and because they're funded by morons giving 10% of their wedge every week, they ensure they're heard, with an array of fulltime workers and ring-in "experts".
Look at the thousands of people who have protested recently against homosexual & marital laws and non-smacking of children. "Spare the rod and you'll spoil the child" the bible tells the religionistas and they believe it. You can bet that every single protestor against anti-smacking laws was a theist of some description or other. (update August 2012 - note the current massive spending campaign by Family First against proposals to allow people of all genders to marry)
I will not stand by and watch these deluded wankers have it all their own way.
Some - especially agnostics - people cry about "evangelical" or militant atheism as though it were a bad thing.
I say that without the soldiers of atheism being in the faces of religion, they would seek to destroy more than they already have. USA is a prime example, where even 87 years after the Scopes monkey trial, religion is trying to take over school curricula and replace science with mythology.
Other reading on the subject includes this article from Huffington Post, the best part of which is not the idiotic, unreferenced and unresearched article itself, but the comments that follow it and give the true picture of atheism and religion in USA.
The idea that "new" atheism is unnecessary or overdone is just more romantic bullshit from the promoters and apologists for religion.
If you follow the kind of religion like the Anglican Church promotes, I have no beef with you. If you find that the delusion of god makes you happy, then I'm happy. It's only when you try to impose your will on others I get pissed off.
But if you're the kind of religionista who feels that the world must conform to your delusion of a sky-daddy, then the only thing which separates you from islamist extremist with AK47s is that you're living in the privileged western world. As Jesus Camp showed us, even allegedly christian religions have elements of extremism every bit as spiteful and abusive as the worst excesses of Wahabiism.
I cringe at people whose delusions are so powerful they would rather watch someone die in agony rather than allow to die with dignity.
You can bet your last buck that the same cruel theist who would deny euthanasia for a human will be off to the vet to euthanase a loved pet rather than watch it suffer a lingering, painful death.
Double standards. Love 'em.
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William Wilberforce: biography and bibliography
Posted: at 6:34 am
Biography William Wilberforce is perhaps the best known of the abolitionists. He came from a prosperous merchant family of Kingston-upon-Hull, a North Sea port which saw little in the way of slave trading. (His birthplace is now preserved as the Wilberforce House Museum.) At twenty-one, the youngest age at which one could be so elected, he was returned to Parliament for his native town. Four years later he was again returned to Parliament, this time for the county seat of Yorkshire which was large and populous, and which therefore required an expensive election contest. The advantage was that the election, being genuinely democratic, conferred a greater legitimacy to the two Members which that county returned to Parliament. Wilberforce's early years in Parliament were not untypical for a young back-bencher. He was noted for his eloquence and charm, attributes no doubt enhanced by his considerable wealth, but he did not involve himself at first with any great cause. A sudden conversion to evangelical Christianity in 1785 changed that and from then onwards he approached politics from a position of strict Christian morality. In 1786 he carried through the House of Commons a bill for amending criminal law which failed to pass the Lords, a pattern which was to be repeated during his abolitionist career. The following year he founded the Proclamation Society which had as its aim the suppression of vice and the reformation of public manners. Later in 1787 he became, at the suggestion of the Prime Minister, William Pitt the Younger, the parliamentary leader of the abolition movement, although he did not officially join the Abolition Society until 1794.
The story of Pitt's conversation with Wilberforce under an old tree near Croydon has passed into the mythology of the anti-slavery movement. The result was that Wilberforce returned to London having promised to look over the evidence which Thomas Clarkson had amassed against the trade. As he did so he clearly become genuinely horrified and resolved to give the abolition movement his support. Working closely with Clarkson, he presented evidence to a committee of the Privy Council during 1788. This episode did not go as planned. Some of the key witnesses against the trade, apparently bribed or intimidated, changed their story and testified in favour. In the country at large abolitionist sentiment was growing rapidly. While the king's illness and the Regency Bill crisis no doubt supplanted the slave trade as the chief topic of political conversation in the winter of 1788-9, by the spring the king had recovered and abolition was once more at the top of the agenda. It was under these circumstances that Wilberforce prepared to present his Abolition Bill before the House of Commons. This speech, the most important of Wilberforce's life to that point, was praised in the newspapers as being one of the most eloquent ever to have been heard in the house. Indeed, The Star reported that 'the gallery of the House of Commons on Tuesday was crowded with Liverpool Merchants; who hung their heads in sorrow - for the African occupation of bolts and chains is no more'.
The newspaper was premature in sounding the death knell of the slave trade. After the 1789 speech parliamentary delaying tactics came into play. Further evidence was requested and heard over the summer months and then, on 23 June 1789, the matter was adjourned until the next session. Wilberforce left town, holidaying at Buxton with Hannah More, confident that the next session would see a resolution of the debate and abolition of the trade. It did not and by January 1790 the question was deemed to be taking up so much parliamentary time that consideration of the evidence was moved upstairs (as parliamentary jargon has it) to a Select Committee. Evidence in favour of the trade was heard until April, followed by evidence against. In June Pitt called an early general election. Wilberforce was safely returned as a Member for Yorkshire, but parliamentary business was disrupted. Despite being behind schedule, Wilberforce continued to work for an abolition which it appeared the country wanted. News of the slave rebellion in Dominica reached Britain in February 1791 and hardened attitudes against abolition, but Wilberforce pressed on. After almost two years of delay the debate finally resumed and Wilberforce again addressed the Commons on 18 April 1791.
When, on the following night, the House divided on the question of abolition fewer than half of its Members remained to vote. Because of this or not, the Abolition Bill fell with a majority of 75 against abolishing the slave trade. Wilberforce and the other members of the Abolition Committee returned to the task of drumming up support for abolition both from Members of Parliament and from ordinary people. More petitions were collected, further meetings held, extra pamphlets published, and a boycott of sugar was organised. The campaign was not helped by news of the revolutions in France and Haiti. Perhaps sensing that a hardening of attitudes was becoming increasingly likely Wilberforce again brought the question of abolition before the House and, almost a year after the previous defeat, on 2 April 1792, once more found himself addressing the House of Commons. Every account we have of this speech shows that it was an intense and lengthy emotional harangue. Public feeling was outraged and, on this occasion, so was the feeling of the House. But not quite enough. Henry Dundas suggested an amendment to the Abolition Bill: the introduction of the word 'gradual'. The bill passed as amended, by 230 votes to 85, and gradual abolition became law, the final date for slave trading to remain legal being later fixed at 1796. But this gave the 'West India Interest' - the slave traders' lobby - room to manoeuvre. Once again parliamentary delaying tactics came into play, further evidence was demanded, and it became clear that gradual abolition was to mean no abolition.
This event marked a turning point in the fortunes of the abolition camapign. Partly because of a hardening of attitudes caused by the outbreak of war with France, and partly because of determined resistance from the West-India Interest there was a collapse in public enthusiasm for the cause. Some abolitionists withdrew from the campaign entirely. Wilberforce did not, but his speeches fell on ever deafer ears. Although Wilberforce reintroduced the Abolition Bill almost every year in the 1790s, little progress was made even though Wilberforce remained optimistic for the long-term success of the cause. He directed some of his efforts into other arenas, largely evangelical or philanthropic, and was instrumental in setting up organisations such as The Bible Society and The Society for Bettering the Condition of the Poor. In 1797 he published a book, A Practical view of the Prevailing Religious System of Professed Christians, a work of popular theology with a strong evangelical hue which sold well on publication and throughout the nineteenth century. On 30 May 1797, after a short romance, he married Barbara Ann Spooner.
If the first two years of the new century were particularly bleak ones for the abolition movement, the situation was rapidly reversed in 1804. The association of abolitionism with Jacobinism dispersed as Napoleon's hostility to emancipation became known. Members of Parliament, especially the many new Irish members, increasingly tended toward abolition. The Abolition Society reformed with a mixture of experienced older members and new blood. Wilberforce assumed his old role of parliamentary leader, and introduced the Abolition Bill before parliament. The Bill fell in 1804 and 1805, but gave the abolitionists an opportunity to sound out support. In 1806, Wilberforce published an influential tract advocating abolition and, in June that year, resolutions supporting abolition were passed in parliament. A public campaign once again promoted the cause, and the new Whig government was in favour as well. In January 1807, the Abolition Bill was once again introduced, this time attracting very considerable support, and, on 23 February 1807, almost fifteen years after Dundas had effectively wrecked abolition with his gradualist amendment, Parliament voted overwhelmingly in favour of abolition of the slave trade. During the debate the then Solicitor-General, Sir Samuel Romilly, spoke against the trade. His speech concluded with a long and emotional tribute to Wilberforce in which he contrasted the peaceful happiness of Wilberforce in his bed with the tortured sleeplessness of the guilty Napoleon Bonaparte. In the words of Romilly's biographer;
The Abolition Act received the Royal Assent (became law) on 25 March 1807 but, although the trade in slaves had become illegal in British ships, slavery remained a reality in British colonies. Wilberforce himself was privately convinced that the institution of slavery should be entirely abolished, but understood that there was little political will for emancipation. Already recognised as an elder statesman in his 50s, Wilberforce received a steady throng of visitors and supplicants, and he became involved in many of the political questions of the day. He supported Catholic Emancipation and the Corn Laws. His health was poor, however, and in 1812 he resigned the large and arduous seat of Yorkshire for the pocket borough of Bramber. In the same year he started work on the Slave Registration Bill, which he saw as necessary to ensure compliance with the Abolition Act. If slaves were registered, he argued, it could be proved whether or not they had been recently transported from Africa. The Prime Minister, Spencer Perceval, supported the Bill, but was assassinated shortly after. Thereafter, Wilberforce's efforts met with increasing resistance from the government. In 1815, with the government again blocking progress, Wilberforce publically declared that as they would not support him, he felt himself no longer bound by their line on emancipation. From this time on, Wilberforce campaigned openly for an end to the institution of slavery.
Wilberforce's health, never good, was deteriorating. Although now free to speak his mind on emancipation, he was never able to campaign with the same vigour that he had done for abolition of the trade. However, he continued to attack slavery both at public meetings and in the House of Commons. In 1823, he published another pamphlet attacking slavery. This pamphlet was connected with the foundation of The Anti-Slavery Society which led the campaign to emancipate all slaves in British colonies. Leadership of the parliamentary campaign, however, was passed from Wilberforce to Thomas Fowell Buxton. In 1825, Wilberforce resigned from the House of Commons. He enjoyed a quiet retirement at Mill Hill, just north of London, although he suffered some financial difficulties. His last public appearance was at a meeting of the Anti-Slavery Society in 1830, at which, at Thomas Clarkson's suggestion, he took the chair. In parliament, the Emancipation Bill gathered support and received its final commons reading on 26 July 1833. Slavery would be abolished, but the planters would be heavily compensated. 'Thank God', said Wilberforce, 'that I have lived to witness a day in which England is willing to give twenty millions sterling for the Abolition of Slavery'. Three days later, on 29 July 1833, he died. He is buried in Westminster Abbey.
Brycchan Carey 2000-2002
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Political freedom – Wikipedia, the free encyclopedia
Posted: at 6:34 am
Political freedom (also known as a political autonomy or political agency) is a central concept in history and political thought and one of the most important features of democratic societies.[1] It was described as freedom from oppression[2] or coercion,[3] the absence of disabling conditions for an individual and the fulfillment of enabling conditions,[4] or the absence of life conditions of compulsion, e.g. economic compulsion, in a society.[5] Although political freedom is often interpreted negatively as the freedom from unreasonable external constraints on action,[6] it can also refer to the positive exercise of rights, capacities and possibilities for action, and the exercise of social or group rights.[7] The concept can also include freedom from "internal" constraints on political action or speech (e.g. social conformity, consistency, or "inauthentic" behaviour).[8] The concept of political freedom is closely connected with the concepts of civil liberties and human rights, which in democratic societies are usually afforded legal protection from the state.
Various groups along the political spectrum naturally differ on what they believe constitutes "true" political freedom.
Left wing political philosophy generally couples the notion of freedom with that of positive liberty, or the enabling of a group or individual to determine their own life or realize their own potential. Freedom, in this sense, may include freedom from poverty, starvation, treatable disease, and oppression, as well as freedom from force and coercion, from whomever they may issue.
Friedrich Hayek, a well-known classical liberal, criticized this as a misconception of freedom:
[T]he use of "liberty" to describe the physical "ability to do what I want", the power to satisfy our wishes, or the extent of the choice of alternatives open to us... has been deliberately fostered as part of the socialist argument... the notion of collective power over circumstances has been substituted for that of individual liberty.[9]
Anarcho-socialists see negative and positive liberty as complementary concepts of freedom. Such a view of rights may require utilitarian trade-offs, such as sacrificing the right to the product of one's labor or freedom of association for less racial discrimination or more subsidies for housing. Social anarchists describe the negative liberty-centric view endorsed by capitalism as "selfish freedom".[10]
Anarcho-capitalists see negative rights as a consistent system. Ayn Rand described it as "a moral principle defining and sanctioning a mans freedom of action in a social context. To such libertarians, positive liberty is contradictory, since so-called rights must be traded off against each other, debasing legitimate rights which, by definition, trump other moral considerations. Any alleged "right" which calls for an end result (e.g. housing, education, medical services) produced by people is, in effect, a purported "right" to enslave others.[citation needed]
Some notable philosophers, such as Alasdair MacIntyre, have theorized freedom in terms of our social interdependence with other people.[11]
According to political philosopher Nikolas Kompridis, the pursuit of freedom in the modern era can be broadly divided into two motivating ideals: freedom as autonomy or independence; and freedom as the ability to cooperatively initiate a new beginning.[12]
Political freedom has also been theorized in its opposition to (and a condition of) "power relations", or the power of "action upon actions," by Michel Foucault.[13] It has also been closely identified with certain kinds of artistic and cultural practice by Cornelius Castoriadis, Antonio Gramsci, Herbert Marcuse, Jacques Ranciere, and Theodor Adorno.
Environmentalists often argue that political freedoms should include some constraint on use of ecosystems. They maintain there is no such thing, for instance, as "freedom to pollute" or "freedom to deforest" given that such activities create negative externalities. The popularity of SUVs, golf, and urban sprawl has been used as evidence that some ideas of freedom and ecological conservation can clash. This leads at times to serious confrontations and clashes of values reflected in advertising campaigns, e.g. that of PETA regarding fur.
John Dalberg-Acton stated that "The most certain test by which we judge whether a country is really free is the amount of security enjoyed by minorities."[14]
Hannah Arendt traces the origins of the concept of freedom to the practice of politics in ancient Greece. According to her study, the concept of freedom was historically inseparable from political action. Politics could only be practiced by those who had freed themselves from the necessities of life, so that they could attend to the realm of political affairs. According to Arendt, the concept of freedom became associated with the Christian notion of freedom of the will, or inner freedom, around the 5th century C.E. and since then, freedom as a form of political action has been neglected, even though, as she says, freedom is "the raison d'tre of politics."[15]
Arendt says that political freedom is historically opposed to sovereignty or will-power, since in ancient Greece and Rome, the concept of freedom was inseparable from performance, and did not arise as a conflict between the "will" and the "self." Similarly, the idea of freedom as freedom from politics is a notion that developed in modern times. This is opposed to the idea of freedom as the capacity to "begin anew," which Arendt sees as a corollary to the innate human condition of natality, or our nature as "new beginnings and hence beginners."[citation needed]
In Arendt's view, political action is an interruption of automatic process, either natural or historical. The freedom to begin anew is thus an extension of "the freedom to call something into being which did not exist before, which was not given, not even as an object of cognition or imagination, and which therefore, strictly speaking, could not be known."[citation needed]
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