Monthly Archives: January 2016

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Posted: January 8, 2016 at 12:42 pm

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Exchange Rates | CoinWarz – Cryptocurrency Mining vs. Bitcoin …

Posted: at 2:43 am

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(BCX)

(BQC)

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(BEN)

(BET)

(BIG)

(BTB)

(BTC)

(BTG)

(BTM)

(BLC)

(CAP)

(BCN)

(CAI)

(CANN)

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Space Station – NASA Blogs

Posted: January 7, 2016 at 3:43 am

Astronauts Tim Kopra and Tim Peake work on U.S. spacesuits inside the Quest airlock where spacewalks are staged. Credit: NASA TV

Two astronauts are preparing a pair of U.S. spacesuits to get ready for next weeks spacewalk to continue the maintenance of the International Space Station. In the midst of those preparations, the six-member Expedition 46 crew is proceeding with ongoing space science to improve life on Earth and benefit future astronauts.

Tim Kopra from NASA and Tim Peake from the European Space Agency will be the spacewalkers on Jan. 15. They will work outside for about six-hours and 30-minutes to replace a failed voltage regulator, rig cables for future International Docking Adapters and perform other maintenance tasks.

The station residents also worked throughout the day on a variety of experiments exploring human research, physics and other advanced subjects.

Commander Scott Kelly joined cosmonaut Mikhail Kornienko for the Fluid Shifts study. That experiment observes how microgravity increases brain pressure which may push back on a crew members eyes, resulting in changes to their vision. Peake and Kopra also participated in life science experiments exploring heart function during long-term space missions and the efficacy of medications in space.

NASA astronaut Tim Kopra is seen floating during a spacewalk on Dec. 21, 2015.

Astronauts Tim Peake and Tim Kopra are getting ready for a spacewalk next week to replace a failed voltage regulator. The duo are scheduled to work outside for 6.5 hours on Jan. 15 for the replacement work and other tasks.

In preparation, Kopra worked on the U.S. spacesuits today that he and Peake will wear next week. Peake, a British astronaut with the European Space Agency, began collecting and configuring their spacewalk tools.

The Expedition 46 crew also continued more advanced space science research onboard the International Space Station. Commander Scott Kelly joined his fellow One-Year crew member Mikhail Kornienko for the Fluid Shifts study. That experiment explores how microgravity increases brain pressure which pushes back on a crew members eyes,resulting in changes to their vision.

Cosmonaut Sergey Volkov studied radiation exposure, how international crews relate during missions and worked on maintenance tasks. His fellow cosmonaut and flight engineer Yuri Malenchenko looked at magnetic fields and coulomb crystals and transferred cargo from the newest Progress 62 cargo craft.

Tropical Cyclone Ula, a category 3 storm at the time this image was captured, is seen from the International Space Station. Credit: NASA TV

The Expedition 46 crew begins its first full week of the New Year planning for a spacewalk scheduled for Jan. 15. The orbiting residents are also busy with numerous science experiments benefitting life on Earth and future astronauts.

A pair of spacewalkers will replace a failed voltage regulator to return power to one of eight power channels next Friday. Two crew members will exit the Quest airlock and work outside for 6.5 hours for the replacement work. They will also rig cables for the future installation of docking adapters that will enable commercial crew vehicles to dock at the International Space Station. Final spacewalking roles will be confirmed following spacesuit hardware checkouts taking place today.

NASA astronauts Tim Kopra and Commander Scott Kelly collected and stowed blood and urine samples this morning for the Fluid Shifts study. That experiment observes the headward fluid shift caused by microgravity that increases brain pressure and pushes back on the eye. British astronaut Tim Peake also explored particles suspended in fluids, or colloids, which could benefit the design of advanced materials on Earth.

Engineering video from a camera on the Progress 62 spacecraft shows the docking target on the Pirs docking compartment.

Traveling about 253 miles over western Mongolia, the unpiloted ISS Progress 62 Russian cargo ship docked automatically with the Pirs docking compartment of the International Space Station at 5:27 a.m. EST today. Progress is delivering 2.8 tons of food, fuel, and supplies to the crew aboard the station.

The spacecraft launched Monday from the Baikonur Cosmodrome in Kazakhstan. Following a by-the-book rendezvous and docking with the Progress upgraded Kurs automated system, hooks formed a hard mate between the spacecraft and the Pirs docking compartment. Once the crew completes leak checks, the hatches will open, allowing the crew to unload the cargo.

The Progress spacecraft will remain docked until early July 2016.

For more information about the International Space Station, visit: http://www.nasa.gov/station.

NASA astronaut Tim Kopra is seen floating during a spacewalk on Dec. 21, 2015.

A pair of spacewalkers are cleaning up and reporting back to ground controllers after a short spacewalk Monday morning. A Christmas delivery is also due at the International Space Station Wednesday at 5:31 a.m. EST/10:31 a.m. UTC.

Commander Scott Kelly and Flight Engineer Tim Kopra quickly prepared over the weekend for the spacewalk to release a stalled robotic transporter. As the pair suited up in the Quest airlock Monday, a Progress 62 (62P) cargo spaceship launched on a two-day trip to deliver 2.8 tons of food, fuel, and supplies for the Expedition 46 crew.

The stalled robotic transporter needed to be moved then latched to its worksite ahead of the Progress arrival triggering Mondays spacewalk. The Progress is a modified design and Russian mission controllers are testing its upgraded software and telemetry systems during its flight to the Pirs docking compartment.

Cosmonauts Yuri Malenchenko and Sergey Volkov are preparing for the Progress arrival by testing the TORU tele-robotic rendezvous system. The TORU system would be used in the unlikely event it would be necessary to manually guide the vehicle to a docking.

The crew also had time set aside for advanced space science today. The orbiting lab residents explored plant growth and life science as humans learn to live longer and farther in space.

Spacewalkers Scott Kelly and Tim Kopra work to move stalled robotic transporter before moving on to get-ahead tasks. Credit: NASA TV

NASA astronauts Scott Kelly and Tim Kopra ended their spacewalk at 11:01 a.m. EST with the repressurization of the U.S. Quest airlock after accomplishing all objectives. They released brake handles on crew equipment carts on either side of the space stations mobile transporter rail car so it could be latched in place ahead of Wednesdays docking of a Russian cargo resupply spacecraft. The ISS Progress 62 resupply mission launched at 3:44 a.m. EST this morning (2:44 p.m. Baikonur time) from the Baikonur Cosmodrome in Kazakhstan.

After quickly completing their primary objective for the spacewalk, Kelly and Kopra tackled several get-ahead tasks. Kelly routed a second pair of cables in preparation for International Docking Adapter installment work to support U.S. commercial crew vehicles, continuing work he began during a November spacewalk. Kopra routed an Ethernet cable that ultimately will connect to a Russian laboratory module. They also retrieved tools that had been in a toolbox on the outside of the station, so they can be used for future work.

The three-hour and 16-minute spacewalk was the third for Kelly, who is nine months into a yearlong mission and the second for Kopra, who arrived to the station Dec. 15. It was the 191st in support of assembly and maintenance of the orbiting laboratory. Crew members have now spent a total of 1,195 hours and 20 minutes working outside the orbital laboratory.

Stay up-to-date on the latest ISS news at: http://www.nasa.gov/station.

Spacewalkers Scott Kelly and Tim Kopra.

NASA astronauts Scott Kelly and Tim Kopra switched their spacesuits to battery power at 7:45 a.m. EST, signifying the start of todays spacewalk, planned for about three hours.

Kelly is wearing a spacesuit with red stripes and is designated EV1. His helmet camera displays the number 18. Kopra is wearing a spacesuit with no stripes and is designated EV2. His helmet camera displays the number 17.

The astronauts are embarking on the 191st spacewalk in support of space station assembly and maintenance to move the space stations mobile transporter rail car a few inches from its stalled position so it can be latched in place ahead of Wednesdays docking of a Russian cargo resupply spacecraft.

If the primary task of moving the transporter to its worksite is completed quickly, Kelly and Kopra may press on to a few get-ahead tasks that include the routing of cables in advance of International Docking Adapter installment work to support U.S. commercial crew vehicles, and opening a door housing power distribution system relay boxes just above the worksite to facilitate the future robotic replacement of modular components.

NASA Television is broadcasting the spacewalk at http://www.nasa.gov/nasatv.

Follow @Space_Station and #spacewalk on Twitter to join the conversation online.

The Progress 62 rocket launches from Kazakhstan on a two-day trip to the International Space Station: Credit: NASA TV

Carrying more than 2.8 tons of food, fuel, and supplies for the International Space Station crew, the unpiloted ISS Progress 62 cargo craft launched at 3:44 a.m. EST (2:44 p.m. local time in Baikonur) from the Baikonur Cosmodrome in Kazakhstan.

Less than 10 minutes after launch, the resupply ship reached preliminary orbit and deployed its solar arrays and navigational antennas as planned.The Russian cargo craft will make 34 orbits of Earth during the next two days before docking to the orbiting laboratory at 5:31 a.m. Wednesday, Dec. 23.

At 8:10 a.m. EST, Expedition 46 Commander Scott Kelly and Flight Engineer Tim Kopra of NASA will exit the stations U.S. Quest airlock to conduct a previously unplanned spacewalk to help move the stations mobile transporter rail car so it can be latched in place prior to arrival of the Progress spacecraft. NASA TV coverage of the planned three-hour spacewalk will begin at 6:30 a.m.

Watch live on NASA TV and online at http://www.nasa.gov/nasatv.

NASA Television will provide live coverage of Progress 62s arrival to the space stations Pirs docking compartment beginning at 5 a.m. Wednesday.

To join the online conversation on Twitter, follow @Space_Station. To learn more about all the ways to connect and collaborate with NASA, visit: http://www.nasa.gov/connect.

The Progress 62 Rocket stands at its launch pad at the Baikonur Cosmodrome in Kazakhstan. Credit: RSC Energia

Beginning Monday, Dec. 21 at 3:30 a.m. EST, NASA Television will provide live coverage of the launch of a Russian Progress spacecraft carrying more than three tons of food, fuel, and supplies for the Expedition 46 crew aboard the International Space Station. Launch of ISS Progress 62 from the Baikonur Cosmodrome in Kazakhstan is planned for 3:44 a.m. (2:44 p.m. local time in Baikonur).

Watch the launch live on NASA TV or at http://www.nasa.gov/nasatv

Following a 34-orbit, two-day trip, Progress 62 is scheduled to arrive at the Pirs Docking Compartment of the International Space Station at 5:31 a.m. on Wednesday, Dec. 23. The two-day rendezvous was deliberately planned to enable Russian flight controllers to test new software and communications equipment on the vehicle that will be standard for future Progress and piloted Soyuz spacecraft. The Expedition 46 crew will monitor key events during Progress 62s automated rendezvous and docking.

The Progress will spend more than six months at the station before departing in early July 2016.

To join the online conversation on Twitter, follow @Space_Station. To learn more about all the ways to connect and collaborate with NASA, visit: http://www.nasa.gov/connect.

NASA astronauts Scott Kelly and Tim Kopra will conduct a spacewalk Monday morning. Credit: NASA

The International Space Station Mission Management Team met Sunday and gave its approval to proceed with a spacewalk Monday out of the Quest airlock by Expedition 46 Commander Scott Kelly and Flight Engineer Tim Kopra of NASA to assist in moving the Mobile Transporter rail car a few inches to a worksite on the stations truss where it can be latched in place and electrically mated to the complex. The green light for the unplanned spacewalk to take place Monday came three days after the Mobile Transporter stalled just four inches away from its embarkation point at worksite 4 near the center of the stations truss as it began to move to another worksite to support robotic payload operations with its attached Canadarm2 robotic arm and the Special Purpose Dexterous Manipulator (Dextre).

Station managers ordered the spacewalk to latch down the transporter as a cautionary measure in advance of the scheduled docking of the new unpiloted ISS Progress 62 cargo ship on Wednesday that will link up to the Pirs Docking Compartment. The Progress is on track for launch from the Site 31 launch pad at the Baikonur Cosmodrome in Kazakhstan Monday at 2:44 a.m. Central time (2:44 p.m. Baikonur time).

The planned 3 to 3 hour spacewalk is scheduled to begin Monday at 7:10 a.m. Central time. The start time for the spacewalk is variable since Kopra will be conducting a fit check of his U.S. spacesuit in parallel with other spacewalk preparations. NASA TV coverage will begin at 5:30 a.m. Central time.

Kelly, who will be making his third spacewalk, will be extravehicular crew member 1 (EV 1) wearing the U.S. spacesuit bearing the red stripes. Kopra, who arrived on the station on Dec. 15, will be making the second spacewalk of his career as extravehicular crew member 2 (EV 2) wearing the suit with no stripes. It will be the 191st spacewalk in support of station assembly and maintenance and the seventh spacewalk of the year by station crew members.

Kelly and Kopra will float out of the Quest airlock to the area where the Mobile Transporter has stalled to check out the position of its brake handles and other mechanisms to make sure the rail car can be commanded to move back to worksite 4 by robotic flight controllers at Mission Control, Houston. It is suspected that a brake handle on an equipment cart attached to the starboard side of the transporter may have inadvertently engaged, which if correct, should easily be released to allow for the transporter to be moved into place for its latching.

If the primary task of moving the transporter to its worksite is completed quickly, Kelly and Kopra may press on to a few get-ahead tasks that include the routing of cables in advance of International Docking Adapter installment work to support U.S. commercial crew vehicles, and opening a door housing power distribution system relay boxes just above the worksite to facilitate the future robotic replacement of modular components.

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International Space Station: Pictures, Videos, Breaking News

Posted: at 3:43 am

We have only existed a short time on this planet, and we know other species, such as the dinosaurs, did not survive due to planetary changes. That makes the study of other planets, and the ability to travel to them, crucial to the future of human existence.

How far are we from developing fully self-sufficient space stations? originally appeared on Quora - the knowledge sharing network where compelling que...

Quora

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Let's get this over with once and for all: We are going to Mars. The only questions are: When? Who? How? Which way? And, of course, why?

Rick Tumlinson

Founder - New Worlds Institute, EarthLight Foundation, SpaceDiver Inc., Co-Founder, Deep Space Industries, Space Frontier Foundation, Orbital Outfitters Inc.

The F-35 joint strike fighter, the United States' most expensive warplane to date, was supposed to cost $1.5 trillion over 50 years. The current contract is seven years behind schedule and $163 billion over budget. Here are four other things the US could have bought with the waste from the program.

Where are the neighbors? Where are the schools and community organizations? Who reaches out to see what the problem is? Does anyone see this child/youth desperately in need of help and hope? Who listens or offers a helping hand amidst the violence and despair they face daily?

Becoming detached from the International Space Station (ISS) during an EVA (spacewalk) is a low probability occurrence. While not likely to happen, since it is possible, astronauts prepare for it.

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A rocket can be fixed. A mindset has to be changed or those holding it made irrelevant.

Rick Tumlinson

Founder - New Worlds Institute, EarthLight Foundation, SpaceDiver Inc., Co-Founder, Deep Space Industries, Space Frontier Foundation, Orbital Outfitters Inc.

Almost 100 years ago, on November 25, 1915, Albert Einstein presented to the Prussian Academy of Sciences the final version of his general theory of relativity, which also became the standard theory of gravity.

Hanoch Gutfreund

Former president of the Hebrew University of Jerusalem and academic director of the Albert Einstein Archives.

We don't know the answer to that. But every crew that resides on the International Space Station provides us information that we use to adjust our protocols and that extends that period of time.

Quora

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Let's ignore the technologies that might be impossible (e.g. warp drive, dilithium crystals, and transporters). Let's ignore the technologies that we have no idea how to reproduce in a similar way (artificial gravity). Let's just focus on trying to build a space-worthy scale replica of the USS Enterprise that uses existing structural and propulsion capabilities.

Quora

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Yes, I know the current push by our Federal Space Agency on social media is #JourneytoMars, but are we ready? Really ready? Nope, I don't think we're even close.

Clayton Anderson

U.S. Astronaut (Ret.); Author of The Ordinary Spaceman; ISS and Space Shuttle spacewalker; Aquanaut

Navigation requires a reference frame. We need reference frames to tell us where we are with respect to other objects and we need reference frames to tell us how we are oriented with respect to other objects. There is no single universal frame that is used for all operations.

Quora

The best answer to any question

Move over, stiff neck; there's a new spinal problem to reckon with. Doctors are seeing some patients with "text neck"--pain caused by inclining one's head for long periods of time while staring at a smartphone, thus putting extra stress on the spine.

I took off my helmet and it felt like I was holding the anchor of the U.S.S. Nimitz in my hand. Oh great, I thought, how am I ever going to brush my teeth -- the brush will be too heavy!

Quora

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SpaceX has an impressive half dozen commercial launches to its name and a manifest of launch orders from domestic and international clients stretching into the future. They've managed to do this the old fashioned way, by being cheaper, faster and more reliable.

Greg Autry

Assistant Prof. of Clinical Entrepreneurship at USC, Economist with the Coalition for a Prosperous American; Co-author 'Death by China'

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International Space Station: Pictures, Videos, Breaking News

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Space Station – TV Tropes

Posted: at 3:43 am

An artificial structure in space, where people live and work. Unlike the Cool Starship, the Space Station is usually fixed in orbit around a planet or at a particular point in space. It also allows for the construction of a standing studio set and avoids expensive location shoots. Real-world space stations have existed since 1971 (Salyut 1) and 4 of themthe International Space Station, the Chinese Tiangong-1, and Genesis I & II (both unmanned)are currently in orbit. These are all much smaller than what one is used to in sci-fi shows. The list for the interested can be seen below. Space stations in fiction have a tendency to be very large, sometimes housing an entire city. Many have adopted a wheel design for a centrifuge-based system of gravity (unless Artificial Gravity is employed), but this is not obligatory. If sufficiently large to support a sizable permanent population, a space-station may be referred to as an "orbital habitat" or "space colony". Don't drop it! The problem of gas exchange and food production is often solved by incorporating a closed ecosystem and green plants onboard, sometimes in dirt, sometimes hydroponics, sometimes algae aquaculture. Fictional examples:

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Space Station - TV Tropes

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How Space Stations Work – HowStuffWorks

Posted: at 3:43 am

In the exploration of the western frontier of the Unites States, pioneers had forts or staging points where they departed to venture into the unexplored territories. Similarly, in the early 20th century, pioneering space scientists, such as Hermann Oberth, Konstantin Tsiolkovsky, Hermann Noordung and Wehrner von Braun, dreamed of vast space stations orbiting the Earth. Like forts in the western frontier, these scientists envisioned space stations as staging points for the exploration of outer space.

Wehrner von Braun, the architect of the American space program, integrated space stations into his long-term vision of U.S. space exploration. To accompany von Braun's numerous space articles in popular magazines, artists drew concepts of space stations. These articles and drawings helped fuel public imagination and interest in space exploration, which was essential to establishing the U.S. space program (for more, see How the Space Race Worked).

In these space station concepts, people lived and worked in outer space. Most of the stations were wheel-like structures that rotated to provide artificial gravity. Like any port, ships traveled to and from the station. The ships carried cargo, passengers, and supplies from Earth. The departing flights went to Earth, the Moon, Mars and beyond. As you know, this general concept is no longer merely a vision of scientists, artists and science fiction authors. But what steps have been taken to build such orbiting structures? While mankind has not yet realized the full visions of von Braun and others, there have been significant strides in building space stations.

The United States and Russia have had orbiting space stations since 1971. The first space stations were the Russian Salyut program, the U.S. Skylab program and the Russian Mir program. And since 1998, the United States, Russia, the European Space Agency, Canada, Japan and other countries have been building and operating the International Space Station (ISS) in Earth orbit. With the ISS, humans have been living and working in outer space for more than 10 years.

In this article, we'll examine the early space station programs, the uses of space stations, and the future role of space stations in the exploration of outer space. But first, let's consider more fully why many people think we should be building space stations.

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How Space Stations Work - HowStuffWorks

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Why We Get Old: Programmed to die?

Posted: January 6, 2016 at 3:43 am

If you're alive in 20 years, you may be able to live forever.

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In 1786, average life expectancy was just 24 years. A hundred years later (1886) it doubled to 48. Right now a newborn can expect to live an average of 76 years. With recent discoveries in biology, many scientists predict that life expectancy will continue to triple-digits. In fact, if they are correct, humans shouldn't have to die at all in the future.

"Over half the baby boomers here in America are going to see their hundredth birthday and beyond in excellent health. We're looking at life spans for the baby boomers and the generation after the baby boomers of 120 to 150 years of age." -- Dr. Ronald Klatz of the American Academy of Anti-Aging.

Today's quest for the fountain of youth is taking scientists inside the genetic structure of cells and paying less attention to the role of stress and diet on life spans. Would-be immortals flock to anti-aging clinics and shell out as much as $20,000 a year for treatments that include hormone therapy, DNA analysis, even anti-aging cosmetic surgery. These experimental therapies offer no guarantees of immortality -- just the promise of prolonging life.

"Anti-aging medicine is not about stretching out the last years of life. It's about stretching out the middle years of life... and actually compressing those last years few years of life so that diseases of aging happen very, very late in the life cycle, just before death, or don't happen at all." -- Dr. Klatz.

Why do we age and die?

The cause of what we call "aging" is now being understood. This new understanding may soon move anti-aging cosmetics and surgery to the ranks of snake oil and Siberian yogurt as life-extension fads -- but not yet. There are a few obstacles that need to be addressed.

Just when you thought that holographic TV and outer space travel were on the future horizon of modern technology, immortality has silently been revealing itself to scientists like Doctor John Langmore [right] of the University of Michigan's Department of Biology.

Dr. Langmore and his group looked inside human cells, at the very essence of human life: the DNA molecule. Specifically, Dr. Langmore looked at the tips of the DNA molecule -- a previously overlooked part of the double-helix molecule -- that contain a kind of chain of repeating pairs of enzymes.

Called telomeres, these molecular chains have often been compared to the blank leaders on film and recording tape. Indeed, telomeres seem to perform a similar function. During the replication process the spiral DNA molecule must split in half and reassemble a copy of itself. Protecting the vital DNA molecule from being copied out of synch, telomeres provide a kind of buffer zone where mis-alignments (which are inevitable) will not result in any of the important DNA code being lost.

Perhaps the best analogy I have heard is to compare the telomeres to the white margin surrounding an important type written document. In this analogy, the printed text is the vital DNA code while the white space is the "blank" telomeres. Imagine that this paper is repeatedly slapped on a copy machine, a copy is made, and then that copy is used to make another copy. Each time the paper is subject to errors of alignment and these errors accumulate. After enough copying, it is probable that the white space will diminish and some of the actual text will not be copied. That's what happens inside our cells and it is the reason we get old and die.

As any cell gets older, it is under attack by oxides and free-radicals in the body and environment. We survive as living beings because our cells have the ability to duplicate and replace themselves before being killed by these natural causes. Each time our cells divide, the DNA molecule makes a new copy of itself.

[Right: DNA is a complex molecule that resembles a spiral ladder. When it divides, it splits along the "rungs" then each half of this "ladder" rebuilds the missing half -- viola! -- two DNA molecules. Now the cell can divide. The old cell dies and the new cell continues on.]

But the procedure is very complex and not perfect. Usually a small portion of the DNA molecule is lost, misaligned and not copied. Since errors are more frequent on the ends of the DNA molecule, this area, the telomere, does not contain any important DNA information and the effect is insignificant.

Telomeres -- programmed to die!

Scientists observe that the length of telomere chains becomes shorter as we grow older. Eventually the telomeres become so short that cell replication produces lethal errors or missing pieces in the DNA sequence, ending the cell's ability to replace itself. This point, when the cell has lost vital DNA code and cannot reproduce, is called the Hayflick limit. It's the measure of how many times a cell can copy itself before it dies.

Some cells in our body have a very high hayflick limit. Cells that line the inside of your mouth and intestines, for example, are constantly being worn away and replaced. Indeed these cells appear to have the ability to regrow telomeres even in aged bodies. Scientists were curious why some cells shut down telomere growth with age, and some do not.

Dr. Langmore used physical, biochemical, and genetic techniques to study the structure and function of telomeres. His group developed a cell-free system to reconstitute functional model telomeres using synthetic DNA, and studied the mechanism by which telomeres normally stabilize chromosomes and how shortening of the telomeres could cause instability.

The protein factors responsible for stabilizing the ends of chromosomes are being identified, cloned, and studied. Electron microscopy is used to directly visualize the structure of the model telomeres. Dr. Langmore's group used new enzymatic assays to determine the structure of telomere DNA in normal and abnormal cells grown in vivo and in vitro, in order to address specific hypotheses about the role of telomeres in aging and cancer. It's exciting research, for sure, and there have been some promising discoveries.

Scientists have discovered an important enzyme that can turn the telomere production on the DNA molecule "on" and "off." It's called telomerase. Not surprisingly, it seems that as we get older, the amount of telomerase in our cells decreases.

The Cancer Problem

You might be wondering why biologists don't simply find a way to keep our body's telomeres long. This would prevent replication errors and humans could live indefinitely. The big problem is cancer.

Usually, if a cell makes an error in copying itself, the error will prevent the cell from duplicating itself in the future. So the mistake is limited. But with cancer, cells with errors somehow "turn on" the production of telomerase and make the mutant cell immortal. Now, aberrant cells can reproduce unchecked and outlive normal cells. This is the process that creates tumors.

Since we all have mutant, pre-cancerous cells in our bodies, nature has decided to shut off the telomerase as we age, thus preventing these mutant cells from growing telomeres. It's a kind of programmed death -- a trade off to reduce our lifespan in order to save us from being riddled with tumors. Nevertheless, some pre-cancerous cells manage to re-activate their telomeres and this has caused the research to focus more on blocking telomere production rather than trying to extend it.

[Right: A 3-d rendering of the telomerase enzyme.] The molecular structure shows an interesting "groove" (show in green) where the enzyme attaches to the end of the DNA molecule.

Ant-cancer researchers believe that by introducing a molecule to block this groove, the telomerase would become unable to attach itself to the DNA and thereby limit the length of telomere production. While this work holds hope for stopping tumor cells from reproducing forever, it does little to extend healthy cells from being rejuvinated. However, if the molecular "blocker" could specifically target only cancerous cells, without blocking telomerase activity in healthy cells, it could be a step towards human life extension if and when a pharmaceutical can be developed that activates telomerase in the human body. [4]

Viewzone asked Dr. Langmore to give us his thoughts on the role of telomerase, and the possibilities of using it to repair and lengthen telomeres in human cells. His comments follow:

Telomeres are special, essential DNA sequences at both ends of each chromosome. Each time chromosomes replicate a small amount of the DNA at both ends is lost, by an uncertain mechanism. Because human telomeres shorten at a much faster rate than many lower organisms, we speculate that this telomere shortening probably has a beneficial effect for humans, namely mortality. The telomere hypothesis of aging postulates that as the telomeres naturally shorten during the lifetime of an individual, a signal or set of signals is given to the cells to cause the cells to cease growing (senesce). At birth, human telomeres are about 10,000 base pairs long, but by 100 years of age this has been reduced to about 5,000 base pairs.

Telomerase is actually an enzyme (a catalytic protein) that is able to arrest or reverse this shortening process. Normally, telomerase is only used to increase the length of telomeres during the formation of sperm and perhaps eggs, thus ensuring that our offspring inherit long "young" telomeres to propagate the species.

Dr. Langmore: The telomere hypothesis of cancer is that the function of telomere shortening is to cause cells that have lost normal control over growth to senesce (i.e. stop growing) before being able to replicate enough times to become a tumor, thus decreasing the frequency of cancer.

Immortal cells like cancer have an unfair advantage over normal human cells which are designed to senesce. But nature seems to have planned this human telomere shortening perhaps to prolong life by hindering the otherwise unchecked growth of non-immortal or benign tumors. Malignant, or immortal tumors can simply outlive the rest of the organism.

Malignant cancer cells are being studied because they appear to have altered the shortening of telomeres by turning "on" the telomerase. Thus it appears that some cancers and aging are both connected with the biology of telomeres.

It is possible that increasing telomerase activity in normal cells might stop the biological clock of aging, yet the side effect of this intervention might be an increase in the rate of cancer. Further understanding and refinement in the telomere hypothesis might lead to a way to slow the aging process and prevent or arrest cancer.

However telomeres function, they are an integral part in the very complex process of cell growth, involving many other factors as well. Telomerase might be the Achilles Heal of aging and cancer, but as our understanding of factors that interact with telomerase, factors that are responsible for telomere shortening in the first place, and non-telomerase mechanisms for increasing the length of telomeres, we might find that one of these factors is more easily manipulated to slow aging or prevent cancer. Also there are additional factors that affect aging and cancer, which might prove in the end to be more important than telomeres and telomerase.

ViewZone: Are telomeres unique to individual DNA? If so, does this preclude any universal treatment for aging?

Dr. Langmore: Different individuals have telomeres with exactly the same DNA sequence but of different lengths. It is too early to say whether there is any relationship between telomere length in an individual and his or her life expectancy, or whether a treatment that would artificially lengthen telomeres would arrest (or reverse) the aging process. One problem is that even in one individual the telomeres of different chromosomes have very different lengths. Therefore an individual might have on average long telomeres; but, he might have one chromosome with a very short telomere that could affect cell growth.

ViewZone: In the work of Shay and Wright (see below), increased telomere length was positively associated with telomerase. How significant is this?

Dr. Langmore: Shay, Wright and all their many collaborators stimulated telomerase activity in normal cells. This was expected to 1) Increase the length of telomeres and 2) Prolong the lifetime of the cells in tissue culture. The treatment did both, in perfect agreement with the telomere hypothesis of aging.

ViewZone: How much was cell lifetime prolonged due to this treatment that reactivated telomerase?

Dr. Langmore: The increased proliferation of the cells was perhaps equivalent to hundreds of years of human life.

Dr. Langmore received his Ph.D. degree from the University of Chicago in 1975. He has held postdoctoral fellowships at the Laboratory of Molecular Biology in Cambridge and at the University of Basel.

[Above:] One of the more surprising developments in telomere structure was the discovery by collaborative efforts from Jack Griffith's and Titia de Lange's groups that mammalian telomeres looped back on themselves to form large lariat-like structures, called t-loops (Griffith et al., 1999).

This structure may help to conceal the end of the molecule from DNA damage surveillance mechanisms and guard against recognition of the chromosome terminus as a double-strand break. [11]

More links to cancer

In the March 15 issue of the European Molecular Biology Organization (EMBO) Journal, Dr. Jerry Shay and Dr. Woodring Wright, both professors of cell biology and neuroscience at UT Southwestern Medical Center at Dallas, report manipulating the length of telomeres to alter the life span of human cells. Shay and Wright are the first to report this important finding. They received an Allied-Signal Award for Research on Aging to explore this line of research last year.

"By lengthening the telomere, we were able to extend the life of the cell hybrids," Wright explained. "This study is strong evidence that telomere length is the clock that counts cell divisions."

"The expression of the enzyme telomerase maintains stable telomere length. Telomerase is not detected in normal cells and telomeres shorten and then the cells stop dividing and enter a phase called cellular senescence."

Shay and Wright have shown in earlier studies that telomeres maintain their length in almost all human cancer cell lines. This correlated with inappropriate expression of telomerase and as a consequence allowed the cell to become "immortal." Cell immortality is a critical and perhaps rate-limiting step for almost all cancers to progress. Previous work by the UT Southwestern investigators showed that in a special group of advanced pediatric cancers the lack of telomerase activity correlated with critically shortened telomeres and cancer remission.

Naturally, the exploration of this enzyme is now the focus of much investigation, but for now the research is aimed at understanding how to turn telomeres "off" to limit the spread of "immortal" cancer cells.

Abnormally high levels of telomerase have been found in cancerous breast cells and have been evident in many kinds of tumors.[1]

Consequently, an idea gaining momentum is that the ability to measure and perhaps alter telomere length and/or telomerase activity may give physicians new diagnostic and treatment tools for managing the care of patients with cancer.

Shay and Wright tried to alter already-immortal cells by attempting to inhibit telomerase activity and cause telomeres to shorten. "Unexpectedly, we found the opposite result. Rather than inhibiting telomerase, our treatment caused the immortal cells to develop longer telomeres," Shay explained. "Although we were surprised with the result, we now know there is a causal relationship between telomere length and the proliferate capacity of cells.

"Essentially, we combined the tumor cells containing experimentally elongated telomeres with normal cells and extended the life span of those cell hybrids compared to similar hybrids using cells without experimentally elongated telomeres."

Shay and Wright said the mechanism that causes telomeres to lengthen is still unclear. However, Shay said, "Our observations increase confidence in the hypothesis that immortal cells and reactivated telomerase are essential components of human tumors. Ultimately, we may be able to regulate tumor cells by inhibiting telomerase activity."

The potential implications for research on human aging also are significant. "It is still speculative, but understanding the role of telomere shortening in cell aging may give us the information we need to increase the life span of an organism," Wright said. (News Releases from UT Southwestern)

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Why We Get Old: Programmed to die?

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Freedom N.Y., Inc.

Posted: January 5, 2016 at 12:41 am

The purpose of the Freedom N.Y. Newsletter is to communicate to the world the FACTS about the injustices that were handed to the company. Freedom N.Y., Inc. a Bronx N.Y. based Defense Prime Meals Ready To Eat (MRE) Contractor that thrived in the 1980s. For over the past two decades, Freedom has fought to unbury itself from the lies and deceptions used illegally to halt its production lines of MREs (the sort of meals now being fed to our troops in Iraq). Freedom's contract was breached 26 times and, as a result of these wrongful breaches of contract, lost its MRE Industrial Preparedness Prime contractor position within the Department of Defense. Additionally, Freedom has lost over 442 jobs as well as a massive 400,000 sq ft U.S.D.A. approved plant in the South Bronx of N.Y.

Freedom has been involved in a court battle for some time to set the record straight about what happened. This website will reveal the factual events that took place during the contract period. And will include recent court findings, ruling and decisions that confirmed what Freedom said happened over 17 years ago.

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Freedom N.Y., Inc.

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Natasha Vita-More | Transhuman Art

Posted: January 4, 2016 at 5:42 pm

Natashas research concerns the aesthetics of human enhancement and radical life extension, with a focus on sciences and technologies of nanotechnology, biotechnology, information technology, and cognitive and neuro sciences (NBIC). Her conceptual future human design Primo Posthuman has been featured in Wired, Harpers Bazaar, Marie Claire, The New York Times, U.S. News & World Report, Net Business, Teleopolis, and Village Voice. She has appeared in over twenty-four televised documentaries on the future and culture, and has exhibited media artworks at National Centre for Contemporary Arts, Brooks Memorial Museum, Institute of Contemporary Art, Women In Video, Telluride Film Festival, and United States Film Festival and recently Evolution Haute Couture: Art and Science in the Post-Biological Age. Natasha has been the recipient of several awards: First Place Award at Brooks Memorial Museum, Special Recognition at Women in Video, and Best Graduate Student Project of 2005 for her Futures Podcast Series: at the University of Houston, Future Studies program.

Natasha is a proponent human rights and ethical means for human enhancement, and is published in Artifact, Technoetic Arts, Nanotechnology Perceptions, Annual Workshop on Geoethical Nanotechnology, Death And Anti- Death. She has a bi-monthly column in Nanotechnology Now, is a Guest Editor of The Global Spiral academic journal and on the Editorial Board of International Journal of Green Nanotechnology. Natasha authored Create / Recreate: the 3rd Millennial Culture on the emerging cybernetic culture and the future of humanism and the arts and sciences. She co-authored One on One Fitness, a guide to nutrition and aerobic and anaerobic exercise for women. Her new book The Transhumanist Reader: Classical and Contemporary Look at Philosophy and Technology is scheduled for publishing in 2012 through Wiley-Blackwell.

Natasha is Chair of Humanity+, international non-profit 501c3 organization and was the former president of Extropy Institute, networking organization Natasha continues to work with academic institutions, non-profit organizations and business about human futures. She is a track advisor at the Singularity University, on the Scientific Board of Lifeboat Foundation, a Fellow of the Institute for Ethics and Emerging Technologies, Visiting Scholar at 21st Century Medicine, and advises non-profit organizations including Adaptive A.I. and Alcor Life Extension Foundation. She has been a consultant to IBM on the future of human performance.

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Natasha Vita-More | Transhuman Art

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Dark Roasted Blend: Category: Futurism

Posted: at 5:40 pm

Quintessential Space Pulp Art by Ron Turner and others

Is it a dream, or a nightmare?

Dramatic Rescues, Aliens and the Apocalypse

Damsels in distress, all over the time and space

Floating laps of luxury, and more!

Part of our Futurism category, an essential overview

H.G. Wells & Jules Verne would approve

Russian, Italian and British Pulp SF Art

Share your life with a bunch of cute Japanese toy robots!

Making you hate your current family car since 1951

Plus super-fantastic toys attack!

Gentlemen! Forward - Into the Past!

From RetroFuture to Algorithmic Architecture

Giant Robot Structures Around the World... Standing... Waiting...

Atoms in the Air, on Wheels, Rails, etc.

Futuristic shapes, Greyhound-style

Part 2 of the highly popular series

The greatest invention that never was

Glamour and Stupendous Size, All-in-One

Love, Peace, and - Metropolis

Rare, gorgeous futuristic space art from unlikely sources

Alluring steel-plated companions

The craziest vehicle ideas you ever likely to see

Past, Present and Retro-future

Vintage Space Travel Posters, and more.

NASA's most radical killer asteroid defense

Overview of the Pulp SciFi Art

Soviet Unique Glass Holders, and more

Grand dream realized

Not just really big cities... Cities the size of mountains

Every kind, except the yellow ones

These forms cry out "FUTURE!" in a way that cannot be ignored.

Love them, or hate them, there is no middle ground

Black-and-white rare series of images

Modern Italian Design + RetroFuturism Style

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When living in mega-cities was considered a privilege

Part 1: rare vintage space graphics

Would you ditch your car for one of these systems?

Exciting Innovations in Transportation

Exciting Innovations in Transportation

Sky Captain's dream come true

The DIY guide for the discerning nerd

High-Speed Train Visions & Prototypes

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Dark Roasted Blend: Category: Futurism

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