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Daily Archives: October 2, 2015
Liberty House Restaurant – Jersey City, NJ
Posted: October 2, 2015 at 11:44 pm
Perfect Night Reviewed on 12/03/2012 Tracy S
The Liberty House was the site of our perfect Thanksgiving weekend wedding. Our family and friends were blown away at absolutely everything: the views, the gardens, the cocktail room, the reception space, and the food. Danielle was an AMAZING help for the year we planned our... Read More wedding and was always quick to respond to our many requests and the evening went off without a hitch. The staff at the Liberty House were phenomenal and worked so hard to make sure we were comfortable, fed, and filled with liquor! The space was beautiful and I can't wait to return year after year to have an anniversary dinner at their restaurant.
I got married the week Hurricane Sandy hit the east coast. The entire state of New Jersey was in chaos and devastation. The Liberty House helped me have my dream wedding. Despite power loss and generator usage, they did everything in their power to make sure the wedding was as... Read More perfect as it could get. The entire venue was filled with candle light, the food was AMAZING, and the service was outstanding. My wedding turned out absolutely amazing - even without power!
I just had my wedding at the Liberty House and it was an AMAZING wedding. The staff, especially Danielle, Miriam and Virginia went above and beyond! Everything was great from the food to the service. My guests were raving to me all night (and still are) about how wonderful the... Read More place was. There really is no better backdrop for your wedding than the amazing views of NYC.
My wedding day was everything I hoped for, and more. I originally planned on having my wedding at a venue in Brooklyn, since that is where I reside. After my first walk through at the Liberty House I was convinced this was where I would marry the love of my life. Alex Argenio... Read More was my wedding coordinator and she was absolutely Amazing!!! She helped with planning all the details and made sure to be there on the big to ensure everything went as planned. We had the ceremony at the garden with 150 guest and I couldn't be happier with how everything turned out. Having the ceremony and reception at the same location was the best decision for us, I think it helped in keeping everything on schedule and made it convenient for the guest to transition. I am so grateful for Vicky the maitre'd who took care of everything the groom and I needed for the night, she was phenomenal!!! I wanted a real wedding where family and friends could eat, drink and have a good time and The Liberty House was the perfect venue for such a special occasion. Following the wedding our guest were raving about the great customer service from the staff, how delicious the food was and the amazing back drop. The city view across the water combined with the greenery of the garden as well as the fire pits and modern chic outdoor decor made it for a stunning ambiance. Deciding where to have a once in a lifetime event it's hard as It is, pick a place where they understand that notion and how much you'll treasure these moments. Good luck bride to be !!!
The Liberty House is an amazingly beautiful venue for a wedding. The views of the city are breathtaking, and all our guests were blow away. We were married in the Liberty Room on the main level. What made our wedding unique is that during the reception we didnt have people... Read More all crammed on the dancefloor. Some people were dancing, some were sitting outside by the firepits toasting marshmallows, others were lighting sparklers, and others were enjoying a cigar and espresso. There was something for everyone. The food is also amazing, and there is tons of it! All our guests commented on how great the food was, and how wonderful and attentive the waitstaff was. The entire staff at the Liberty House was professional, helpful, and very kind. They are masters of creating an amazing wedding day and a countless number of our guests said it was the best wedding they have ever attended. It was the perfect venue for us, and I cant thank the Liberty House staff enough for helping create my dream wedding day!
Flawless Wedding First let me start by saying if Danielle Villa is not your coordinator then she should be! As she is AMAZING!! We had chosen the LH house due to the amazing views of NYC, which would allow for us to have a personal wedding with ~60 guests. The benefits... Read More that Danielle brought We are very busy with our jobs as both my wife and I do a lot of global travel, and we no longer live in NJ, so planning a remote wedding around our work schedules was hectic to say the least. So when we had a question we were delighted to get a quick and concise response from Danielle within 24 hours, and most of the time is was in less than 3 hrs. She was great at detailing out the next steps, as well as offering suggestions for the event. She set up the room, ceremony and our special champagne celebration perfectly! She made it a flawless, drama free day! Benefits of the Liberty house.our guests loved loved loved the food at the cocktail hour. And the views of Manhattan were amazing, especially since it was a blue moon that night. For our event we chose to do the cocktail hour first, this gave our guests time to get to know the venue and mingle with each other. From there we moved to the ceremony where we had the chairs set up in a heart shape, and a champagne bucket in each row allowing for an immediate toast after our I dos. We then moved back to cocktails for a short period before starting dinner. Dinner quickly moved to dancing, more pictures of the skyline, cake and Smores (which were a HUGE hit!). The service the day of our wedding was over the top. We had Chris that ensured things flowed as scheduled, and Elizabeth as our personal attendant and she made sure we had everything we needed. Our goal was to have an informal, fun event that our friends and family would rave about. And that is exactly what we got. Every guest could not say enough about the venue, food, view, and overall day. Overall, would not change a thing when it comes to the Liberty House. And can not stress enoughDanielle is a MUST to have in your corner!
Had our wedding reception at The Liberty House on June 7. Could not have asked for a better experience! Being an event planner, I had high expectations....Danielle Villa and the entire Liberty House staff blew me AWAY. I am more than thrilled with the way everything turned out.... Read More The view is to die for, the food is amazing, and the staff is so attentive (my bridal consultant, Leslie was a DOLL!). You don't find this combination anywhere else. Our guests can't stop talking about our wedding. Said it is the best they've ever been to! All thanks to the amazing Liberty House. To Danielle and team --- thank you for EVERYTHING. it was my dream day!
Our wedding was almost a month ago and we are still getting compliments. All our guest raved about how beautiful the Liberty House was and how delicious the food tasted. My now husband and I had such a pleasant experience dealing with all the staff throughout our... Read More planning. On the day of our wedding, they made it such a special experience. We did not have to go to the bar once as our drinks were always being filled by the bridal attendant. My sister need a pin for my hair and the attendant appeared and had one for her to use. Everything was amazing and we are still talking about how much fun we had at the Liberty House.
When we visited the Liberty House for a friends wedding, we were in awe. We aspired that the venue would be our own one day and it was! We loved our wedding experience there too! We scheduled an appointment and got assigned Danielle. What a fire cracker! I loved her from the... Read More moment I met her. She was friendly, honest, professional, and REAL! When my fiance and I got home the appointment that night, we were still glowing! We called Danielle the next day and locked in our date! We got to know Danielle pretty well over the next few months, especially my husband who I assigned to our payments. We inundated her with silly questions, which were new to us, and she answered them all in a timely matter. She was always one step ahead and knew what documents/info to send over at the appropriate times. The days leading up to the wedding were stressful but having Danielle's final meeting was soothing. We finalized all the details and made a checklist. She was so well organized that it made everything easy. The day of the wedding, everything went off without a hitch! Everything was set up where it was supposed to be and my bridal assistant, Leslie was a gem! Always pleasant and always asking if I needed anything! She was so accommodating; Ive never been so attended to and it felt great on such a special day! Thank you for the memories Liberty House! You are what we dreamt of! Lastly, leaving you with a few helpful tips: - Bring 4 people to your tasting trial. It makes it more fun and its a great way to include your bridal party. Six people was a little too crowded, especially when you had to share a salad. - You get what you pay for. Is the LH more than other locations, sure, but you cant beat the location. Perhaps, switch your wedding to the afternoon to save some bucks. We did. - Make a list of all supplies dropped off at the LH prior to the wedding. This ensures that nothing gets left behind!
My experience with the Liberty House was AMAZING! From beginning to end, Danielle was professional, knowledgeable, and extremely reliable. Throughout the planning process she was very helpful and easy to reach. We had both our ceremony and reception at the Liberty House. Our... Read More reception was in the Liberty Room downstairs, which also gave us access to the outdoor patio. I was very concerned about the weather, but Danielle continually assured me that they would make it work. We ended up having perfect weather, but I knew even if we didnt that Danielle would work hard to make sure everything was beautiful. You cant beat the food or atmosphere of the Liberty House. Our guests said it was the best food they ever tasted! The staff and service at the Liberty House is experienced and efficient. Leslie was my bridal assistant and I have to say that she was a life saver. From the second I stepped off the bus she was right there to help me with my dress and continued to be attentive until I stepped back on the bus at the end of the night. She was experienced and knowledgeable and helped the day to run smoothly for not only myself and my husband, but for our parents and the rest of the bridal party as well. Overall, the Liberty House was just wonderful! I would recommend them to anyone!
The Liberty House far exceeded all my expectations for our wedding reception. The room was stunning, the food was amazing, and the service was beyond compare. I worked closely with Danielle Villa through my two year engagement - she provided us great, responsive service and had... Read More amazing ideas on how to enhance our reception. We were fortunate enough to have a beautiful, clear, October night where people were able to hang out outside in the park during cocktail hour and on the balcony during the reception - and the view of NYC provided the perfect backdrop. Our bridal attendant Leslie was so amazing- she knew exactly what I needed before I knew I needed it!! I felt so taken care of all day and knew I was in capable hands from the moment we selected The Liberty House to host our reception. People are still raving about our beautiful wedding!!
Liberty House Restaurant was the perfect place for our wedding! The food was outstanding, the space is gorgeous, and the views of downtown Manhattan are stunning. Mara McMullen and her team kept me sane the months, weeks, and days leading up to our wedding and helped me with... Read More planning every step of the way. We could not have been happier with the Liberty House and look forward to spending our anniversaries at the restaurant year after year!
I got married at the Liberty House on November 7, 2014 and my guests are STILL talking about it. It was the most amazing wedding and it was everything I had ever dreamed of. I worked with Mara who was incredibly professional, responsive, and super sweet to deal with. She... Read More answered every question I had and worked with me on anything and everything I needed. I would highly recommend her to any bride looking for someone to help make your day a special one. The day/night was unbelievable. First of all the food is exceptional. My guests were raving about it (and still are). Everything from the cocktail hour to the main course and was just absolutely delicious. The view is unbeatable. I love Manhattan and having that be the backdrop of our wedding venue was magical. Walking into the room truly takes your breath away. I had Leslie as my bridal attendant that day and she was beyond amazing. She was there for anything I needed and was such a pleasure. Ladies ask for Leslie because she is amazing and such a wonderful person. She made every request I had and saw them through perfectly. I really cannot say enough about the wonderful experience I had at the Liberty House. Everyone there is amazing and the service the staff provided was outstanding. Here we are almost two weeks later and people who attended our wedding said two things: One, it was the best wedding they have ever been to, and two, the Liberty House was beautiful, the food was excellent, and its a one of a kind place. If you are a bride looking to steer clear from the typical catering hall feel, definitely look into Liberty House. Also the pictures you will get will blow you away. The backdrop of Manhattan is beautiful and my pictures came out amazing. Overall I was so incredibly happy with everything. It truly was the best day of our lives and we have to thank the wonderful staff there for all they did for us but especially to Mara, Leslie, and of course our maitre d Chris who made our day so special. We couldnt have asked for a better day and a better place to have our wedding.
The Liberty House was an amazing wedding venue from start to finish. I initially chose the wedding for the NYC skyline and it did not disappoint. My guest were all amazed with the view and all wanted to know how I found this venue space. In terms of the event the liberty house... Read More was great in adding little extras to my decorations and details to ensure a great reception look. They were very attentive during the entire event and made sure all of my needs and guests needs were met. I couldn't be happier with the venue or service.
My daughter & son in law chose this venue for the breathtaking view of Manhattan. That turned out to be just one of the outstanding attributes of this venue. The food was exceptional, the service was above & beyond. We worked with Danielle as coordinator and Leslie as the... Read More bridal attendant. They both outdid themselves and couldn't do enough for my daughter on the most important day of her life. Thank you to all at The Liberty House for a night we will never forget.
Our son and daughter in law held their wedding reception at The Liberty House in New Jersey earlier this month. We cannot say enough about the venue and the service. Our journey began with Danielle Villa as our coordinator and we were thrilled to be working with her. She was... Read More delightful and answered all of our questions. She responded almost immediately to every question or request. She was as happy as we were to be having this event. She made it oh so easy and fun. Stressless as it were. Jeanne Cretella, the owner of the venue also went out of her way to welcome us and make certain we were pleased with the service. The food was plentiful and very delicious. The service was a 10. The venue looked spectacular and the Manhattan view cannot be duplicated. We could not have asked for more. It was wonderful - a 15 out of 10 !!! We highly recommend this for your special day. Our guests would as well.
First things first.. My wedding was held on October 11th 2014. I am at a complete loss for words at how amazing it all turned out. The liberty house is a beautiful location and Danielle was amazing to work with. She helped bring my vision to life. From the beginning to the end I... Read More felt like a princess. My bridal attendant was on top of everything as well. My guests are still raving about the cocktail hour, dinner and viennese hour. I couldn't be more happier that I chose the liberty house as the venue to work with and working with Danielle made it that much smoother. She is efficient and on top of things 110% and whoever else has their wedding here will feel the exact same way. Thank you landmark hospitality and Danielle for making my wedding fabulous!!
The Liberty House truly exceeded our expectations. To begin, the venue is spectacular with clear views of the downtown skyline. We worked with Danielle to coordinate and she was 100% on top of every last detail, helping to ease any concerns prior to the big day. Our maitre d and... Read More bridal attendant were phenomenal as well and the service was top notch from cocktail hour to end. We were so we'll taken care of, I don't know how anyone could do without this awesome team!
Our wedding coordinator Vivian was amazing! My friends and family loved the venue. The staff in the Liberty Room did a great job! A big thanks to the Liberty House Staff!!!!
We had both our wedding ceremony and reception at Liberty House and everything exceeded our expectations! Everyone we worked with was amazing, Mara was great, super helpful and easy to work with. The location and view are spectacular, add to that fantastic food, signature... Read More drinks, gorgeous fire pits, s'mores, people are still talking about it weeks later! I cannot recommend this venue enough, our day was magical and I couldn't imagine having it anywhere else.
We had our wedding at the Liberty House and if you are at all considering having your wedding there, do it. NOW. Everything about it was amazing. Even if you can forget about the beautiful view and grounds (which you can't), the food, staff, location - anything you can think... Read More of for a venue, was just perfect. We received so many compliments throughout the night and people are still talking about it days later. We loved every second of this experience and that is in large part thanks to the amazing people at Liberty House - especially Mara (our fantastic coordinator), Leslie (our amazing bridal attendant), Chris and another woman whose name I unfortunately can't remember.
Liberty House was wonderful! It's expensive but definitely worth it! The food, service, views and professionalism was outstanding. Our guest raved about the reception. Mara was our event coordinator and she was extremely personable, organized and professional. By husband and... Read More I had some last minute changes the week before the wedding and she was more than accommodating. My bridal attendant was fabulous! She brought us water a couple times while we were taking pictures and went above and beyond. Liberty House also packaged up all of our items for the reception and had them ready within 20 minutes. It was wonderful because we did not lose anything!
Danielle and the entire staff at The Liberty House made my wedding day the most amazing day of my life! No detail was left out and Danielle was incredible to work with. It was raining until 30 minutes before my wedding ceremony but Danielle had faith that everything would work... Read More out and it did! She had her entire staff wiping down chairs and tables up until minutes before guests arrived to ensure I had the wedding of my dreams. From the most delicious food to the most breathtaking grounds, I would recommend The Liberty House to anyone looking for the whole package. Thank you Danielle!
I have to say that I was nervous about this place, but my "Dreammaker" was the best ever. She never broke a sweat, and made our whole day amazing and flawless. They have the most attentive staff! My family is vegetarian, but they loved everything from the cocktail hour to the... Read More buffet dinner. There were soo many options for both the vegetarians and non-vegetarians.
I mean this place is truly amazing. From the views to the food to the service there was not a place they faltered even a little. Danielle was my coordinator and she was warm and helpful and answered all mine and my parents questions without a hint of annoyance. We had a bridal... Read More attendant the night of the event and let me tell you she was amazing as well. Never was my glass empty or my veil out of place. My wedding was perfect and I love that all of guests were able to enjoy the scenic views! Not a single complaint. I would also like to note that we were initially interested in Maritime Parc(across the parking lot) but have found their service lacking and of course their views are not as amazing. With the lawn at Liberty House as a wedding ceremony option, we are so so happy we chose Liberty House instead!
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Liberty House Restaurant - Jersey City, NJ
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Pro-Human Transhuman – TV Tropes
Posted: at 2:41 am
This character has been hit with a Viral Transformation, Emergency Transformation, become a cyborg, demon, magical creature, alien or discovers they were never human at all. Despite this, and regardless of any angst over What Have I Become?, they decide that rather than go down the path of Transhuman Treachery and be a Smug Super, Black Shirt, or The Quisling, they will do everything in their power to stay a part of humanity. And if their new species/transhuman fellows are anti-human, they will vow to protect humanity in a pseudo Faustian Rebellion. This can also include transhumans who cast themselves in a shepherd-like role for mankind. This doesn't include forcibly applying What Measure Is a Non-Super? to bootstrap humanity up, though. That's more of a Visionary Villain who believes Utopia Justifies the Means. Many Friendly Neighborhood Vampires fall in this category. If the transformation is due to The Virus, this requires copious Heroic Willpower. These characters can usually pull off a Sheep in Wolf's Clothing gambit. See also Monster Adventurers. Related to My Species Doth Protest Too Much, which refers to creatures that aren't former humans. Opposite Trope to Transhuman Treachery. Super Trope to Vampire Refugee and Phlebotinum Rebel. See also/compare A God I Am Not.
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Psoriasis Wikipdia
Posted: at 1:45 am
Un article de Wikipdia, l'encyclopdie libre.
Classification et ressources externes
Psoriasis en plaque dans le dos.
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Le psoriasis (du grec ruption galeuse, psore ayant aussi autrefois dsign la gale en France) est une maladie inflammatoire de la peau[1] d'origine inconnue et non contagieuse. Cette affection dermatologique touche 1 3% de la population mondiale.
Dans sa forme bnigne et typique, le psoriasis se caractrise par des lsions rouges et squameuses du cuir chevelu, des genoux et des coudes, associe une atteinte des ongles. Dans les cas graves, l'atteinte cutane peut tre gnralise (rythrodermie) et il peut exister des atteintes des articulations. Cette dermatose volue de faon chronique avec des pousses entrecoupes de priodes de rmissions de dure variable au cours desquelles les lsions sont minimes. Aucun traitement permettant la gurison n'est connu; le traitement propos permet uniquement de contrler l'volution de la maladie, en permettant la rgression transitoire plus ou moins complte des lsions. Le traitement est adapt en fonction de la gravit et du retentissement sur la qualit de vie des patients.
Les causes prcises en sont inconnues bien que, dans prs de 30% des cas, une prdisposition familiale existe, surtout si des facteurs externes viennent se rajouter. La maladie aurait des composantes gntiques, auto-immunes[2], microbiologique et environnementale ou alimentaire (l'arrt de la consommation de produits laitiers ou certaines autres denres reviennent souvent dans les tmoignages de personnes ayant russi s'en dbarrasser sans faire intervenir un traitement en parallle[rf.ncessaire]).
L'piderme se renouvelle trop rapidement, en seulement quatre six jours, au lieu des trois semaines habituelles ce qui engendre des inflammations localises. Les cellules pidermiques s'accumulent la surface de la peau et forment une couche de pellicules blanches appeles squames. Parfaitement inoffensives, celles-ci ont pourtant le dsavantage d'tre inesthtiques. La prsence de nombreux leucocytes dans le derme a suggr le rle du systme immunitaire.
Comme indiqu prcdemment, il existe pour un petit tiers des personnes atteintes une composante familiale au psoriasis (restent dterminer les autres facteurs entrant en jeu): prs de 30% des patients atteints ont un membre de leur famille ayant galement la mme maladie[3]. Un certain nombre de gnes ont t identifis comme marqueurs potentiels de risque, dont le PSORS. Le plus important semble tre le PSORS1 situ sur le chromosome 6 et qui serait responsable de prs du tiers des psoriasis familiaux[4]. Seize gnes (en 2012[5]) ont des mutations pouvant favoriser cette maladie.
Les pousses de psoriasis sont parfois lies au stress. Elles peuvent aussi avoir pour origine un facteur infectieux (infection streptococcique, par exemple). Leur frquence est trs variable et, d'une manire gnrale, le facteur dclenchant de la pousse n'est pas identifiable. La consommation excessive d'alcool est un facteur d'aggravation du psoriasis.
Certains mdicaments exacerbent parfois le psoriasis mais leur arrt doit tre discut au cas par cas, celui-ci pouvant comporter d'autres risques, cardio-vasculaires en particulier. Ce sont essentiellement ceux de la classe des bta-bloquants. D'autres molcules ont t rapportes comme potentiellement aggravantes, avec un risque cependant moindre. Ce sont les sartans[6] et l'nalapril[rf.souhaite].
Au contraire, l'exposition solaire a un rle protecteur net. Durant la grossesse, une diminution des pousses avec une aggravation par contre la suite de celle-ci est gnralement observe. Le mcanisme invoqu est celui d'une immuno-modulation par les taux levs de progestrone et d'strognes qui entranent une stimulation de l'immunit dpendant des lymphocytes B mais une diminution de l'activit immunitaire des lymphocytes T. La progestrone est reconnue comme ayant un rle immuno-modulateur cl durant la grossesse[7].
Certaines formes peuvent se dvelopper la suite d'un traumatisme articulaire.
L'effet inesthtique handicapant le sujet dans sa vie quotidienne, peut s'avrer particulirement dsagrable galement par le biais de dmangeaisons intenses. Le grattage des lsions psoriasiques entrane des piquets hmorragiques dnomms signe d'Auspitz ou signe de la rose sanglante tudi par le dermatologue Heinrich Auspitz[10].
Lorsque le psoriasis s'tend sur les parties gnitales, les relations sexuelles deviennent plus dlicates car elles deviennent trs douloureuses.
Les porteurs de psoriasis auraient un risque plus grand de faire un infarctus du myocarde, d'autant plus que l'atteinte est tendue[11]. Les formes svres ont une mortalit cardio-vasculaire plus importante[12]. Cela pourrait tre en rapport avec une perturbation du mtabolisme lipidique constate chez les patients atteints de psoriasis[13] et avec l'inflammation chronique. Il existe galement une corrlation entre la svrit de la maladie cutane et le risque d'avoir un rtrcissement aortique[14].
Il existe galement un risque accru de survenue d'une insuffisance rnale[15].
Comme les victimes d'arthrite rhumatode, ils deviennent aussi plus sensibles la douleur, semble-t-il en raison d'une nociception renforce par une sorte d'effet de sensibilisation[16]
Elle se fait par pousses avec des rmissions (gurison apparente) plus ou moins compltes atteignant parfois quelques dizaines d'annes. Ou bien les pousses peuvent tre chroniques, disparaitre chaque t pour revenir en hiver.
Il peut galement ne jamais y avoir de rmission (sans traitements mdicamenteux): une fois arriv un certain niveau d'volution trs relatif suivant les individus, le psoriasis se stabilise et peut se maintenir ainsi des annes ou toute une vie.
L'examen au microscope d'un chantillon de peau atteinte n'est gure utile en pratique courante, l'examen clinique tant le plus souvent vident. Cet examen montre une augmentation de l'paisseur de l'piderme, la prsence de nombreux vaisseaux sanguins particulirement tortueux dans le derme avec infiltration dans ce dernier par des leucocytes.
En peau non atteinte, l'examen au microscope est strictement normal.
Le traitement local consiste appliquer une crme sur la zone du psoriasis. Les corticostrodes ont un effet favorable sur le psoriasis, malheureusement les plaques reviennent souvent ds l'arrt du traitement. Ce dernier engendre galement une forme d'insensibilisation, qui oblige augmenter les doses dans le temps. De plus, l'effet n'est plus seulement local si ces pommades sont appliqus sur de vastes zones. Cette forme de traitement devrait donc tre limite des formes aigus ou fortement inesthtiques, pendant une courte priode et sur une surface limite.
Le calcipotriol (calcipotrine) est un driv de la vitamine D3. Normalement, cette dernire est synthtise lors de l'exposition de la peau la lumire ultraviolette solaire. Il s'agit donc ici d'un substitut cette exposition (ou la puvathrapie). La quantit maximale applicable est cependant limite, car, fortes doses, le calcipotriol devient toxique. Le tazarotne est un driv de la vitamine A disponible en pommade. Sa tolrance serait cependant moindre que le calcipotriol[17].
Les goudrons (dont l'huile de cade) taient auparavant frquemment utiliss en application sur le psoriasis mais taient malcommodes car particulirement salissants. Le dithranol est un driv du goudron. Le dithranol a une certaine efficacit, surtout en association avec d'autres traitements mais il est parfois irritant et surtout incommode (trs "tachant"), ce qui en limite lusage.
Les autres traitements incluent l'acide salicylique, les bains, les hydratants de la peau. Ces traitements locaux peuvent tre ventuellement associs.
L'exposition solaire a le plus souvent une influence favorable sur le psoriasis[18],[19]. Cependant, dans 10% des cas, cette exposition sera en fait nfaste[rf.ncessaire]. Le sujet devra alors viter le soleil, ou du moins viter d'tre directement expos ses rayons.
La photothrapie aux ultraviolets B (UVB) est galement conseille, pouvant tre combine d'autres thrapies.
Dans tous les cas, la thrapie par ultra-violets (A ou B) doit tre effectue sous contrle mdical. Elle aboutit un seuil de tolrance variable d'un individu l'autre qu'il est ncessaire de ne pas dpasser. Sans cela le patient s'expose l'hliodermie et aux risques faibles de cancers cutans (pithlioma, mlanomes), risques d'autant plus faibles qu'un patient souffrant de psoriasis a beaucoup plus de contrles dermatologiques qu'un patient moyen, ce qui permet de dceler plus tt un dbut de noplasie.
Pour les formes les plus svres de psoriasis, les mdecins peuvent prescrire des traitements par voie orale (comprim ou glule) ou par injection. Ces traitements sont appels systmiques car les mdicaments sont censs se dissminer dans tout l'organisme. Ils ont souvent des effets secondaires, parfois srieux[21].
Le mthotrexate est un antagoniste d'une vitamine, l'acide folique. S'emploie encore surtout dans l'arthrite psoriasique, peu dans le psoriasis exclusivement cutan. Un rtinode, tel l'acitrtine, est un driv de synthse de la vitamine A pouvant tre prescrit dans les formes modres svres de psoriasis. Chez la femme en ge de procrer ce traitement est tratogne, non seulement pendant la prise du mdicament mais galement pendant les deux annes (24 mois) qui suivent la dernire prise. Les effets secondaires sont en gnral mineurs.
Le psoriasis tant considr proche des maladies auto-immunes, un immunodpresseur comme la ciclosporine peut parfois produire des effets positifs, mais ses effets secondaires sont importants (principalement en raison de l'affaiblissement du systme de dfense immunitaire). L'hydroxyure n'est quasi plus employe. L'alefacept, un anticorps dirig contre des rcepteurs de certains lymphocytes T, n'a plus sa place dans le traitement du psoriasis. L'infliximab est un anticorps monoclonal chimrique anti-TNF. Il s'administre en perfusion de 2 heures, aux semaines 0, 2 et 6, puis toutes les 8 semaines[21].
L'efalizumab est galement un anticorps monoclonal dirig contre un certain type de rcepteurs leucocytaires avec une efficacit court et moyen terme[8]. Il a t retir du march dbut 2009[21]. L'tanercept est un inhibiteur du TNF qui a une bonne efficacit sur l'atteinte cutane mais aussi articulaire du psoriasis[21],[22]. L'adalimumab est un anti-TNF administr en injection sous-cutane toutes les 2 semaines la dose de 40 mg[21].
D'autres mdicaments ou traitements ont t plus ou moins tests: le XP-828L (Dermylex) a prouv une certaine efficacit[23],[24]pour le psoriasis lger modr. De mme, plusieurs anticorps monoclonaux, dont l'ustekinumab[25], ou l'ixekizumab[26], dirigs contre certains types d'interleukines semble tre prometteur, voire plus efficace que l'etanercept[27].
Entre autres nouveaux traitements, la lcithine marine est en cours d'valuation et des rsultats positifs ont dj t publis[28],[29].
Le 23 septembre 2014, la Food and Drug Administration (FDA) a accord une autorisation de mise sur le march laprmilast (Otezla) chez les patients souffrant dun psoriasis en plaques modr svre candidats la photothrapie ou un traitement systmique[30].
Sa prvalence est variable suivant la couleur de la peau: elle est plus frquente chez les personnes de peau blanche, concerne entre 1 et 3% de la population[8] et atteint de manire quivalente les deux sexes.
Le psoriasis connat deux priodes propices: entre 10 et 20 ans et surtout entre 50 et 60 ans[31]. Pour se manifester, cette affection inflammatoire a besoin d'un terrain hrditaire et d'un facteur dclenchant. Si l'un des deux parents est atteint, le risque pour l'enfant de la dvelopper est de 5 10%.
L'une des premires descriptions prcises en a t faite par le britannique Robert Willan dans son trait des maladies de la peau datant de 1808. L'inventeur amricain Benjamin Franklin en souffrait[32]. L'crivain John Updike en a fait la description en voquant sa propre atteinte dans une nouvelle du recueil Problmes (1979).
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