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Monthly Archives: July 2015
Ron Paul: Pictures, Videos, Breaking News
Posted: July 10, 2015 at 7:40 am
Artful advocates advise this about addressing the court: if the facts are on your side, pound the facts; if the law is on your side, pound the law; if neither is on your side, pound the table. Adding to that adage, pusillanimous politicians propose undressing the court: if you fear its decision, strip it of jurisdiction.
At the root of the culture wars lies a fundamental dichotomy in worldviews. Which is more essential to humanity: the individual or the collective?
Dave Pruett
Former NASA researcher; Emeritus Professor of Mathematics, James Madison University
A recent op-ed in the New York Times chastises Rand Paul for being insufficiently libertarian. His critics are particularly upset over his "hawkish" foreign policy, accusing him of abandoning the ideal of individual liberty. The reverse, however, is true
Peter Schwartz
Distinguished Fellow, Ayn Rand Institute; Author, "In Defense of Selfishness"
The younger Paul knows that in the political big leagues, candidates of conviction who refuse to moderate their message or refuse to adapt to the prevailing contemporaneous political sentiment, are often abandoned at the alter by the electoral consumer.
Rich Rubino
Author, 'The Political Bible of Humorous Quotations from American Politics,' 'Make Every Vote Equal What a Novel Idea,' and The Political Bible of Little Known Facts in American Politics
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Ron Paul: Pictures, Videos, Breaking News
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POST HUMAN EXHIBIT CATALOG ESSAY 1992-93 Jeffrey Deitch
Posted: at 7:40 am
POST HUMAN EXHIBIT CATALOG ESSAY 1992-93 Jeffrey Deitch
On most peoples beauty scale, Stacey Stetler would be a 10. A blond, blue-eyed, 5-foot-11 New York model, she has confidently sashayed down the runway for Yves Saint Laurent in Paris and has graced the covers of fashion magazines. But until recently, when Ms. Stetler looked in the mirror she saw less perfection and more flaws. "I was flat-chested," Ms. StetIer said. "You couldnt tell if I was coming or going. My back protruded almost as much as my front." Ms. Stetler enhanced her boyish figure by having breast implants. She is not alone.
The New York Times, 6 February 1992, front page
Stories about breast implants, crash diets, and mood drugs have moved from the health and beauty page to the front page. The public has been galvanized by explosive testimony about sexual harassment and by the sensational rape trials of public figures. Questions about the new boundaries of appropriate interpersonal behavior are attracting unprecedented interest. There is a growing sense that we should take control over our bodies and our social circumstances rather than just accepting what we inherited.
Social and scientific trends are converging to shape a new conception of the self, a new construction of what it means to be a human being. The matter-of-fact acceptance of ones "natural" looks and ones "natural" personality is being replaced by a growing sense that it is normal to reinvent oneself. The Freudian model of the "psychological person" is dissolving into a new model that encourages individuals to dispense with the anguished analysis of how subconscious childhood experiences molded their behavior. There is a new sense that one can simply construct the new self that one wants, freed from the constraints of ones past and ones inherited genetic code.
Human evolution may be entering a new phase that Charles Darwin never would have envisioned. The potential of genetic reconstitution may be quickly propelling us beyond Darwinian natural evolution and into a bold realm of artificial evolution. Our society will soon have access to the biotechnology that will allow us to make direct choices about how we want our species to further evolve. This new techno-evolutionary phase will bring us far beyond eugenics. Our childrens generation could very well be the last generation of "pure" humans.
This new sense of ones power to control and, if desired, reconstruct ones body has quickly developed a broad acceptance1 but there is still a significant segment of society that is deeply disturbed by its implications. The bitter debate over abortion rights is an example of how explosive the controversy over the limits of "natural" life will become. The battle over the abortion issue and the outcry over euthanasia and the right to choose suicide may be just the beginning of an enormous social conflict over ones freedom to use the new biotechnology to take greater control over ones body and to enhance the course of ones life.
The issue of using genetic engineering to "improve" the fetus will potentially become much more highly charged than the controversy over abortion. It may not be an exaggeration to say that it will become the most difficult moral and social issue that the human species has ever faced. Genetic engineering is not just another life-enhancing technology like aviation or telecommunications. Its continued development and application may force us to redefine the parameters of life.
Our consciousness of the self will have to undergo a profound change as we continue to embrace the transforming advances in biological and communications technologies. A of the self will inevitably take hold as ever more powerful body-altering techniques become commonplace. As radical plastic surgery computer-chip brain implants and gene-splicing become routine, the former structure of self will no longer correspond to the new structure of the body. A new post-human organization of personality will develop that reflects peoples adaptation to this new technology and its socioeconomic effects.
New approaches to self-realization are generally paralleled by new approaches to art. With each successive transformation of the social environment, great artists have both reflected and helped to define the new personality models that have developed out of societys absorption of technological, political, and social change. Looking back through the history of art, we can see how artists have portrayed the changes in models of self-realization that have accompanied profound changes in the social environment.
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POST HUMAN EXHIBIT CATALOG ESSAY 1992-93 Jeffrey Deitch
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zizek/post-human – lacan
Posted: at 7:40 am
Les particules elementaires, Michel Houellebecq's bestseller from 1998 which triggered a large debate all around Europe, and now finally available in English, is the story of radical DESUBLIMATION, if there ever was one. Bruno, a high-school teacher, is an undersexed hedonist, while Michel, his half-brother, is a brilliant but emotionally desiccated biochemist. Abandoned by their hippie mother when they were small, neither has ever properly recovered; all their attempts at the pursuit of happiness, whether through marriage, the study of philosophy, or the consumption of pornography, merely lead to loneliness and frustration. Bruno ends up in a psychiatric asylum after confronting the meaninglessness of the permissive sexuality (the utterly depressive descriptions of the sexual orgies between forty-somethings are among the most excruciating readings in contemporary literature), while Michel invents a solution: a new self-replicating gene for the post-human desexualized entity. The novel ends with a prophetic vision: in 2040, humanity collectively decides to replace itself with genetically modified asexual humanoids in order to avoid the deadlock of sexuality - these humanoids experience no passions proper, no intense self-assertion that can lead to destructive rage.
Almost four decades ago, Michel Foucault dismissed "man" as a figure in the sand that is now being washed away, introducing the (then) fashionable topic of the "death of man." Although Houellebecq stages this disappearance in much more naive literal terms, as the replacement of humanity with a new post-human species, there is a common denominator between the two: the disappearance of sexual difference. In his last works, Foucault envisioned the space of pleasures liberated from Sex, and one is tempted to claim that Houellebecq's post-human society of clones is the realization of the Foucauldian dream of the Selves who practice the "use of pleasures." While this solution is the fantasy at its purest, the deadlock to which it reacts is a real one: in our postmodern "disenchanted" permissive world, the unconstrained sexuality is reduced to an apathetic participation in collective orgies depicted in Les particules - the constitutive impasse of the sexual relationship (Jacques Lacan's il n'y a pas de rapport sexuel) seems to reach here its devastating apex.
We all know of Alan Turing's famous "imitation game" which should serve as the test if a machine can think: we communicate with two computer interfaces, asking them any imaginable question; behind one of the interfaces, there is a human person typing the answers, while behind the other, it is a machine. If, based on the answers we get, we cannot tell the intelligent machine from the intelligent human, then, according to Turing, our failure proves that machines can think. - What is a little bit less known is that in its first formulation, the issue was not to distinguish human from the machine, but man from woman. Why this strange displacement from sexual difference to the difference between human and machine? Was this due to Turing's simple eccentricity (recall his well-known troubles because of his homosexuality)? According to some interpreters, the point is to oppose the two experiments: a successful imitation of a woman's responses by a man (or vice versa) would not prove anything, because the gender identity does not depend on the sequences of symbols, while a successful imitation of man by a machine would prove that this machine thinks, because "thinking" ultimately is the proper way of sequencing symbols... What if, however, the solution to this enigma is much more simple and radical? What if sexual difference is not simply a biological fact, but the Real of an antagonism that defines humanity, so that once sexual difference is abolished, a human being effectively becomes indistinguishable from a machine.
Perhaps the best way to specify this role of sexual love is through the notion of reflexivity as "the movement whereby that which has been used to generate a system is made, through a changed perspective, to become part of the system it generates."1 This appearance of the generating movement within the generated system as a rule takes the form of its opposite; say, in the later stage of a revolutionary process when Revolution starts to devour its own children, the political agent which effectively set in motion the process is renegated into the role of its main obstacle, of the waverers or outright traitors who are not ready to follow the revolutionary logic to its conclusion. Along the same lines, is it not that, once the socio-symbolic order is fully established, the very dimension which introduced the "transcendent" attitude that defines a human being, namely SEXUALITY, the uniquely human sexual passion, appears as its very opposite, as the main OBSTACLE to the elevation of a human being to the pure spirituality, as that which ties him/her down to the inertia of bodily existence? For this reason, the end of sexuality in the much celebrated "posthuman" self-cloning entity expected to emerge soon, far from opening up the way to pure spirituality, will simultaneously signal the end of what is traditionally designated as the uniquely human spiritual transcendence. All the celebrating of the new "enhanced" possibilities of sexual life that Virtual Reality offers cannot conceal the fact that, once cloning supplements sexual difference, the game is over.
And, incidentally, with all the focus on the new experiences of pleasure that lay ahead with the development of Virtual Reality, direct neuronal implants, etc., what about new "enhanced" possibilities of TORTURE? Do biogenetics and Virtual Reality combined not open up new and unheard-of horizons of extending our ability to endure pain (through widening our sensory capacity to sustain pain, through inventing new forms of inflicting it) - perhaps, the ultimate Sadean image on an "undead" victim of the torture who can sustain endless pain without having at his/her disposal the escape into death, also waits to become reality? Perhaps, in a decade or two, our most horrifying cases of torture (say, what they did to the Chief-of-Staff of the Dominican Army after the failed coup in which the dictator Trujillo was killed - sewing his eyes together so that he wasn't able to see his torturers, and then for four months slowly cutting off parts of his body in most painful ways, like using clumsy scissors to detach his genitals) will appear as naive children's games.
The paradox - or, rather, the antinomy - of the cyberspace reason concerns precisely the fate of the body. Even advocates of cyberspace warn us that we should not totally forget our body, that we should maintain our anchoring in the "real life" by returning, regularly, from our immersion in cyberspace to the intense experience of our body, from sex to jogging. We will never turn ourselves into virtual entities freely floating from one to another virtual universe: our "real life" body and its mortality is the ultimate horizon of our existence, the ultimate, innermost impossibility that underpins the immersion in all possible multiple virtual universes. Yet, at the same time, in cyberspace the body returns with a vengeance: in popular perception, "cyberspace IS hardcore pornography," i.e. hardcore pornography is perceived as the predominant use of cyberspace. The literal "enlightenment," the "lightness of being," the relief/alleviation we feel when we freely float in cyberspace (or, even more, in Virtual Reality), is not the experience of being bodyless, but the experience of possessing another - aetheric, virtual, weightless - body, a body which does not confine us to the inert materiality and finitude, an angelic spectral body, a body which can be artificially recreated and manipulated. Cyberspace thus designates a turn, a kind of "negation of negation," in the gradual progress towards the disembodying of our experience (first writing instead of the "living" speech, then press, then the mass media, then radio, then TV): in cyberspace, we return to the bodily immediacy, but to an uncanny, virtual immediacy. In this sense, the claim that cyberspace contains a Gnostic dimension is fully justified: the most concise definition of Gnosticism is precisely that it is a kind of spiritualized materialism: its topic is not directly the higher, purely notional, reality, but a "higher" BODILY reality, a proto-reality of shadowy ghosts and undead entities.
This notion that we are entering a new era in which humanity will leave behind the inertia of the material bodies, was nicely rendered by Konrad Lorenz's somewhat ambiguous remark that we ourselves (the "actually existing" humanity) are the sought-after "missing link" between animal and man. Of course, the first association that imposes itself here is the notion that the "actually existing" humanity still dwells in what Marx designated as "pre-history," and that the true human history will begin with the advent of the Communist society; or, in Nietzsche's terms, that man is just a bridge, a passage between animal and overman. What Lorenz "meant" was undoubtedly situated along these lines, although with a more humanistic twist: humanity is still immature and barbarian, it did not yet reach the full wisdom. However, an opposite reading also imposes itself: the human being IS in its very essence a "passage," the finite opens into an abyss.
The ongoing decoding of the human body, the prospect of the formulation of each individual's genome, confronts us in a pressing way with the radical question of "what we are": am I that, the code that can be compressed onto a single CD? Are we "nobody and nothing," just an illusion of self-awareness whose only reality is the complex interacting network of neuronal and other links? The uncanny feeling generated by playing with toys like tamagochi concerns the fact that we treat a virtual non-entity as an entity: we act "as if" (we believe that) there is, behind the screen, a real Self, an animal reacting to our signals, although we know well that there is nothing and nobody "behind," just the digital circuitry. However, what is even more disturbing is the implicit reflexive reversal of this insight: if there is effectively no one out there, behind the screen, what if the same goes for myself? What if the "I," my self-awareness, is also merely a superficial "screen" behind which there is only a "blind" complex neuronal circuit? 2 Or, to make the same point from a different perspective: why are people so afraid of the air crash? It's not the physical pain as such - what causes such horror are the two or three minutes while the plane is falling down and one is fully aware that one will die shortly. Does the genome identification not transpose all of us into a similar situation? That is to say, the uncanny aspect of the genome identification concerns the temporal gap which separates the knowledge about what causes a certain disease from the development of the technical means to intervene and prevent this disease from evolving - the period of time in which we shall know for sure that, say, we are about to get a dangerous cancer, but will be unable to do anything to prevent it. And what about "objectively" reading our IQ or the genetic ability for other intellectual capacities? How will the awareness of this total self-objectivization affect our self-experience? The standard answer (the knowledge of our genome will enable us to intervene into our genome and change for the better our psychic and bodily properties) still begs the crucial question: if the self-objectivization is complete, who is the "I" who intervenes into "its own" genetic code in order to change it? Is this intervention itself not already objectivized in the totally scanned brain?
The "closure" anticipated by the prospect of the total scanning of the human brain does not reside only in the full correlation between the scanned neuronal activity in our brain and our subjective experience (so that a scientist will be able to give an impulse to our brain and then predict to what subjective experience this impulsive will give rise), but in the much more radical notion of bypassing the very subjective experience: what will be possible to identify through scanning will be DIRECTLY our subjective experience, so that the scientist will not even have to ask us what we experience - he will be able to READ IMMEDIATELY on his screen what we experience. (There is a further proof which points in the same direction: a couple of milliseconds before a human subject "freely" decides in a situation of choice, scanners can detect the change in the brain's chemical processes which indicates that the decision was already taken - even when we make a free decision, our consciousness seems just to register an anterior chemical process... The psychoanalytic-Schellingian answer to it is to locate freedom (of choice) at the unconscious level: the true acts of freedom are choices/decisions which we make while unaware of it - we never decide (in the present tense); all of a sudden, we just take note of how we have already decided.) On the other hand, one can argue that such a dystopian prospect involves the loop of a petitio principii: it silently presupposes that the same old Self which phenomenologically relies on the gap between "myself" and the objects "out there" will continue to be here after the completed self-objectivization.
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zizek/post-human - lacan
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Main Hubble Page – Hubble Telescope
Posted: July 9, 2015 at 3:43 am
The Hubble Space Telescope was deployed from the Space shuttle Discovery during STS-31 on April 25, 1990. Since then, there have been 5 servicing missions that continued to upgrade the telescope's scientific instruments and operational systems. Hubble reached a major milestone, its 20th anniversary in orbit, on April 24, 2010.
Hubble imagery has both delighted and amazed people around the world and has rewritten astronomy textbooks with its discoveries.
This Hubble photo is of a small portion of one of the largest-seen star-birth regions in the galaxy, the Carina Nebula. Towers of cool hydrogen laced with dust rise from the wall of the nebula. The pillar is also being pushed apart from within, as infant stars buried inside it fire off jets of gas that can be seen streaming from towering peaks. Credit: NASA, ESA, and M. Livio and the Hubble 20th Anniversary Team (STScI). View larger image
For the latest news on Hubble, visit http://www.nasa.gov/hubble.
To view the rest of this site, click here.
The creation of material for this website through the years has mostly been linked to the Hubble servicing missions. The final servicing mission, the spectacularly successful SM4, took place in May 2009. As a result, this site is no longer updated on a regular basis. The website does contain detailed information on the telescope and its operations, the scientific instruments and other hardware currently on board Hubble, and details about all the servicing missions that were flown during 1993-2009. For the latest science from Hubble, please visit http://www.nasa.gov/hubble, http://www.stsci.edu/hst, and http://www.hubblesite.org/.
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Main Hubble Page - Hubble Telescope
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Hubble Ultra Deep Field 3D – Flixxy.com
Posted: at 3:43 am
"Awesome" doesn't begin to describe this. Its an uplifting and mind-expanding experience to have a glimpse of how the playground of the physical world extends outward farther than one had ever imagined. We pointed the most powerful telescope ever built by human beings at absolutely nothing, just because we were curious, and discovered that we occupy a very tiny place in the heavens, the narrator says. When the Hubble Telescope is pointed at an empty area of the sky, the images of over 10,000 galaxies appear in the telescopes long-range view: Photons of these galaxies have traveled for 13 billion years to record their images for us to see. Also see Hubble Deep Field
Each day the Flixxy team looks through hundreds of new videos to pull out a few we think are the best. The videos we select should raise your spirits and bring more sunshine into your life. All of the videos here are safe for work and safe for all ages. Send us your favorites. Were listening. Its a big world out there on the Web, and well keep looking for the best videos in it. Youll find our popular videos here:
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Hubble Ultra Deep Field 3D - Flixxy.com
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"Search and Seizure" and the Fourth Amendment – FindLaw
Posted: at 3:43 am
The Fourth Amendment to the U.S. Constitution protects personal privacy, and every citizen's right to be free from unreasonable government intrusion into their persons, homes, businesses, and property -- whether through police stops of citizens on the street, arrests, or searches of homes and businesses.
What Does the Fourth Amendment Protect?
In the criminal law realm, Fourth Amendment "search and seizure" protections extend to:
The Fourth Amendment provides safeguards to individuals during searches and detentions, and prevents unlawfully seized items from being used as evidence in criminal cases. The degree of protection available in a particular case depends on the nature of the detention or arrest, the characteristics of the place searched, and the circumstances under which the search takes place.
When Does the Fourth Amendment Apply?
The legal standards derived from the Fourth Amendment provide constitutional protection to individuals in the following situations, among others:
Potential scenarios implicating the Fourth Amendment, and law enforcement's legal obligation to protect Fourth Amendment rights in those scenarios, are too numerous to cover here. However, in most instances a police officer may not search or seize an individual or his or her property unless the officer has:
What if My Fourth Amendment Rights Are Violated?
When law enforcement officers violate an individual's constitutional rights under the Fourth Amendment, and a search or seizure is deemed unlawful, any evidence derived from that search or seizure will almost certainly be kept out of any criminal case against the person whose rights were violated. For example:
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"Search and Seizure" and the Fourth Amendment - FindLaw
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Second Amendment : Pictures, Videos, Breaking News
Posted: at 3:43 am
There's no way to determine if a better armed police or citizen bearing arms could have stopped the Charlie Hebdo massacre. Evidence does show that France has been able to keep a much lower gun homicide rate than America has, but will remain vulnerable to terrorism without a greater ability to crack down on illegal guns in the system.
John A. Tures
Political science professor, LaGrange College in Georgia
At the service the rabbi had nailed it. None of us should have been there. And I shouldn't have been standing in the middle of the police vehicular evidence lot.
Charlie Allenson
Freelance writer, communications facilitator using improv comedy techniques, volunteer music therapist.
Did you ever hear the AAA say that "cars don't kill people, people kill people?" Nobody would ever say something so stupid or dumb. But John Boehner gets away with it every time he and his colleagues cave in to pressure from the NRA and vote to defund CDC research on guns.
In the wake of horrific tragedies in Charleston and Sandy Hook, our national conversation persistently returns to guns, but goes nowhere. Why? In part, I think, because we have ignored a fundamental truth: most Americans think lots of 'common-sense' gun rules are already law.
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Second Amendment : Pictures, Videos, Breaking News
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What is Bitcoin? – Bitcoin, explained – Vox
Posted: at 3:42 am
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Genome Biology
Posted: at 3:41 am
Biology for the post-genomic era
Fully Open Access. Genome Biology covers all areas of biology and biomedicine studied from a genomic and post-genomic perspective. Content includes research, new methods and software tools, and reviews, opinions and commentaries. Areas covered include, but are not limited to: sequence analysis; bioinformatics; insights into molecular, cellular and organismal biology; functional genomics; epigenomics; population genomics; proteomics; comparative biology and evolution; systems and network biology; genomics of disease; and clinical genomics. All content is open access immediately on publication.
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Enter exitrons
Dorothee Staiger and Gordon Simpson discuss the discovery of exon-like introns and their contributions to proteome complexity and phenotypic diversity
Focus on splicing
Chris Burge and Daniel Dominguez discuss how splicing-regulatory proteins modulate assembly of the spliceosome to activate and repress splicing
Diagnosing Mendelian diseases
Advantages over clinical exome sequencing can be achieved by using an NGS-based multiplexing assay involving comprehensive gene panels.
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Genome Biology
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The Human Genome Project (Stanford Encyclopedia of Philosophy)
Posted: at 3:41 am
HGP at the start
The HGP began officially in October 1990, but its origins go back earlier. In the mid-1980s, three scientists independently came up with the idea of sequencing the entire human genome: Robert Sinsheimer, then chancellor of University of California at Santa Cruz, as a way to spend $30 million donated to his institution to build a telescope when that project fell through; Salk Institute researcher Rene Dulbecco as a way to understand the genetic origins of cancer and other diseases; and the Department of Energy's (DOE's) Charles DeLisi as a way to detect radiation-induced mutations, an interest of that agency since the atomic bombings of Hiroshima and Nagasaki. Such a project had become technically feasible due to advances made during the previous decade or two: in the early 1970s, recombinant DNA technologies (use of restriction enzymes to splice DNA, reverse transcriptase to make DNA from RNA, viral vectors to carry bits of DNA into cells, bacterial cloning to multiply quantities of DNA); in the late 1970s, DNA sequencing and use of RFLP (restriction fragment length polymorphism) markers for gene mapping; and in the early to mid-1980s, DNA synthesis, pulsed-field gel electrophoresis, polymerase chain reaction (PCR), and automated DNA sequencing.
Sinsheimer's, Dulbecco's, and DeLisi's idea found supporters among a number of prominent molecular biologists and human geneticistsfor example, Walter Bodmer, Walter Gilbert, Leroy Hood, Victor McKusick, and James D. Watson. However, many molecular biologists expressed misgivings. Especially through 1986 and 1987, there were concerns about the routine nature of sequencing and the amount of junk DNA that would be sequenced, that the expense and big science approach would drain resources from smaller and more worthy projects, and that knowledge of gene sequence was inadequate to yield knowledge of gene function.[1] In September 1986, committees were established to study the feasibility of a publicly-funded project to sequence the human genome: one by the National Research Council (NRC) on scientific merit, and one by the Office for Technology Assessment (OTA) as a matter of public policy. Both committees released reports in 1988. The OTA report, Mapping Our Genes: Genome Projects: How Big, How Fast? downplayed the concerns of scientist critics by emphasizing that there was not one but many genome projects, that these were not on the scale of the Manhattan or Apollo projects, that no agency was committed to massive sequencing, and that the study of other organisms was needed to understand human genes. The NRC report, Mapping and Sequencing the Human Genome, sought to accommodate the scientists concerns by formulating recommendations that genetic and physical mapping and the development of cheaper, more efficient sequencing technologies precede large-scale sequencing, and that funding be provided for the mapping and sequencing of nonhuman (model) organisms as well.
It was the DOE that made the first push toward a Big Science genome project: DeLisi advanced a five-year plan in 1986, $4.5 million was allocated from the 1987 budget, and recognizing the boost the endeavor would provide to national weapons laboratories, Senator Pete Domenici from New Mexico introduced a bill in Congress. The DOE undertaking produced consternation among biomedical researchers who were traditionally supported by the NIH's intramural and extramural programsfor example, Caltech's David Botstein referred to the initiative as DOE's program for unemployed bomb-makers (in Cook-Deegan 1994, p. 98). James Wyngaarden, head of the NIH, was persuaded to lend his agency's support to the project in 1987. Funding was in place in time for fiscal year (FY) 1988 with Congress awarding the DOE $10.7 million and the NIH $17.2 million.[2] The DOE and NIH coordinated their efforts with a Memorandum of Understanding in 1988 that agreed on an official launch of the HGP on October 1, 1990 and an expected date of completion of 2005. Total cost estimated by the NRC report was $3 billion.
The project's specific goals at the outset were: (i) to identify all genes of the human genome (initially estimated to be 100,000); (ii) to sequence the approximately 3 billion nucleotides of the human genome; (iii) to develop databases to store this information; (iv) to develop tools for data analysis; (v) to address ethical, legal, and social issues; and (vi) to sequence a number of model organisms, including the bacterium Escherichia coli, the yeast Saccharomyces cerevisiae, the roundworm Caenorhabditis elegans, the fruitfly Drosophila melanogaster, and the mouse Mus musculans. The DOE established three genome centers in 198889 at Lawrence Berkeley, Lawrence Livermore, and Los Alamos National Laboratories; as Associate Director of the DOE Office of Health and Environmental Research (OHER), David Galas oversaw the DOE's genome project from April 1990 until he left for the private sector in 1993. The NIH instituted a university grant-based program for human genome research and placed Watson, co-discoverer of the structure of DNA and director of Cold Spring Harbor Laboratory, in charge in 1988. In October 1989, the Department of Health and Human Services established the National Center for Human Genome Research (NCHGR) at the NIH with Watson at the helm. During 1990 and 1991, Watson expanded the grants-based program to fund seven genome centers for five-year periods to work on large-scale mapping projects: Washington University, St. Louis; University of California, San Francisco; Massachusetts Institute of Technology; University of Michigan; University of Utah; Baylor College of Medicine; and Children's Hospital of Philadelphia.
As the HGP got underway, a number of philosophers weighed in on its scientific meritin terms of cost, potential impact on other areas of research, ability to lead to medical cures, and the usefulness of sequence data (Kitcher 1995; Rosenberg 1995; Tauber and Sarkar 1992; Vicedo 1992). However, of particular interest to philosophers is goal (v) concerning ethical, legal, and social issues. At an October 1988 news conference called to announce his appointment, Watson, in an apparently off-the-cuff response to a reporter who asked about the social implications of the project, promised that a portion of the funding would be set aside to study such issues (Marshall 1996c). The result was the NIH/DOE Joint Working Group on Ethical, Legal, and Social Implications (ELSI) of Human Genome Research, chaired by Nancy Wexler, which began to meet in September 1989.[3] The Joint Working Group identified four areas of high priority: quality and access in the use of genetic tests; fair use of genetic information by employers and insurers; privacy and confidentiality of genetic information; and public and professional education (Wexler in Cooper 1994, p. 321). The NIH and DOE each established ELSI programs: philosopher Eric T. Juengst served as the first director of the NIH-NCHGR ELSI program from 1990 to 1994. ELSI was funded initially to the tune of three percent of the HGP budget for both agencies; this was increased to four and later five percent at the NIH.
Map first, sequence later
As the NRC report had recommended, priority at the outset of the project was given to mapping rather than sequencing the human genome. HGP scientists sought to construct two kinds of maps. Genetic maps order polymorphic markers linearly on chromosomes; the aim is to have these markers densely enough situated that linkage relations can be used to locate chromosomal regions containing genes of interest to researchers. Physical maps order collections (or libraries) of cloned DNA fragments that cover an organism's genome; these fragments can then be replicated in quantity for sequencing. The joint NIH-DOE five-year plan released in 1990 set specific benchmarks: a resolution of 2 to 5 centimorgans (cM) for genetic linkage maps and physical maps with sequence-tagged site (STS) markers (unique DNA sequences 100200 base pairs long) spaced approximately 100 kilobases (kb) apart and 2-megabase (Mb) contiguous overlapping clones (contigs) assembled for large sections of the genome. Sequencing needed to be made more efficient and less costly: aims were to reduce sequencing costs to $.50 per base and to complete 10 million bases of contiguous DNA (0.3 percent of the human genome) but otherwise to focus efforts on the smaller genomes of less complex model organisms (Watson 1990). HGP goals were facilitated by a number of technological developments during this initial period. For physical mapping, yeast artificial chromosomes (YACs) introduced in 1987 (Burke et al. 1987) permitted much larger segments of DNA to be ordered and stored for sequencing than was possible with plasmid or cosmid libraries. A new class of genetic markers, microsatellite repeats, was identified in 1989 (Litt and Luty 1989; Tautz 1989; Weber and May 1989); because these sets of tandem repeats of short (either dinucleotide, trinucleotide, or tetranucleotide) DNA sequences are more highly polymorphic and detectable by PCR, microsatellites quickly replaced RFLPs as markers of choice for genetic linkage mapping and furnished the STS markers which facilitated the integration of genetic and physical maps. Another technological achievementthe combined use of reverse transcription, PCR, and automated sequencing to map expressed genesled to administrative changes at the NIH when, in April 1992, Watson resigned from his position as director of the NCHGR following a conflict with NIH director Bernadine Healy over gene patenting. In 1991, while working at the NIH, J. Craig Venter sequenced small portions of cDNAs from existing libraries to provide identifying expressed sequence tags (ESTs) of 200300 bases which he then compared to already identified genes from various species found in existing databases (Adams et al. 1991).[4] Watson disagreed with Healy's decision to approve patent applications for the ESTs despite lack of knowledge of their function.[5] Soon after Watson's departure, Venter left NIH for the private sector.[6]
Francis Collins, an MD-PhD whose lab at University of Michigan co-discovered genes associated with cystic fibrosis and neurofibromatosis and contributed to efforts to isolate the gene for Huntington's disease, was appointed by Healy as Watson's replacement, and he began at the NCHGR in April 1993. Collins established an intramural research program at the NCHGR to complement the extramural program of grants for university-based research which already existed; ELSI remained a grant-funded program. The original NIH-DOE five-year plan was updated in 1993. The new five-year plan, in effect through 1998, accommodated progress that had been made in mapping, sequencing, and technological development (Collins and Galas 1993). The goal of a 25 cM genetic map was expected to be met by the 1995 target date. The deadline for a physical map with STS markers at intervals of 100 kb was extended to 1998; a map with intervals averaging 300 kb was expected by 1995 or 1996. Although the goal of $.50 per base cost of sequencing was projected to be met by 1996, it was recognized that this would be insufficient to meet the 2005 target date. The updated goal was to build up to a collective sequencing capacity of 50 Mb per year and to have 80 Mb of DNA (from both human and model organism genomes) sequenced by the end of 1998. This would be achieved by increasing the number of groups working on large-scale sequencing and heightening efforts to develop new sequencing technologies. Accordingly, in November 1995, the U.K.'s Wellcome Trust launched a $75 million, seven-year concentrated sequencing effort at the Sanger Centre in Cambridge, and in April 1996, the NCHGR awarded grants totaling $20 million per year for six centers (Houston's Baylor College of Medicine, Stanford University, The Institute for Genomic Research [TIGR], University of Washington-Seattle, Washington University School of Medicine in St. Louis, and Whitehead Institute for Biomedical ResearchMIT Genome Center) to pilot high-volume sequencing approaches (Marshall 1996a).
Although the HGP's inceptions were in the U.S., it had not taken long for mapping and sequencing the human genome to become an international venture (see Cook-Deegan 1994). France began to fund genome research in 1988 and had developed a more centralized, although not very well-funded, program by 1990. More significant were the contributions of Centre dEtudes du Polymorphisme Humain (CEPH) and Gnthon. CEPH, founded in 1983 by Jean Dausset, maintained a collection of DNA donated by intergenerational families to help in the study of hereditary disease; Jean Weissenbach led an international effort to construct a complete genetic map of the human genome using the CEPH collection; later, with funding from the French muscular dystrophy association (AFM), director Daniel Cohen set out to construct a YAC clone library for physical mapping and oversaw the launching of Gnthon in 1991 as an industrial-sized mapping and sequencing operation funded by the AFM. The U.K.'s genome project received its official start in 1989 although Sydney Brenner had commenced genome research at the Medical Research Council (MRC) laboratory several years before this. MRC funding was supplemented with private monies from the Imperial Cancer Research Fund, and later, the Wellcome Trust. The Sanger Centre, led by John Sulston and funded by Wellcome and the MRC, opened in October 1993. A combined four-year, 15-million-euro genome program by the European Community (E.C.) commenced in 1990. Germany, its citizens all too aware of abuses in the name of genetics, lagged behind other European countries: although individual researchers received government funds for genome research in the late-1980s and participated in the E.C. initiative, no actual national genome project was undertaken until 1995 (Kahn 1996). Japan, ahead of the U.S. in having funded the development of automated sequencing technologies since the early 1980s, was the major genome player outside the U.S. and Europe with several government agencies beginning small-scale genome projects in the late-1980s and early- 1990s, but a frequent target of U.S. criticism for the size of its investment relative to GNP.[7] China was the latecomer on the international scene: with 250 million yuan ($30 million) over three years from government and industry, the Chinese National Human Genome Center with branches in Beijing and Shanghai opened in July 1998, and was followed in 1999 by the Beijing Genomics Institute.[8]
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The Human Genome Project (Stanford Encyclopedia of Philosophy)
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