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Daily Archives: July 12, 2015
Program Information | Johns Hopkins – Institute of Genetic …
Posted: July 12, 2015 at 2:42 pm
Fields of Study and Research
Many general areas of research are available in the Human Genetics program:
Approximately 10 - 12 new students are admitted to the program each year. Our students interact with trainees in several other programs at Hopkins including postdoctoral fellows in Human Genetics, as well as predoctoral students in many of the other graduate programs on the School of Medicine campus including Biochemistry, Cellular and Molecular Biology (BCMB); Neuroscience; Immunology; and Cellular and Molecular Medicine (CMM).
Below are listed the courses required of all students in the program. These includes a human biology core that has been adapted from the basic medical school curriculum. The first course that incoming students will take is Genetics & Medicine: History of Ideas. In this seminar course, students revisit articles that have been the cornerstome of the evolution in the field and discuss the historical and scientific context in which such discoveries were made.
Further on, our students are required to take courses that are part of the core curriculum for BCMB and other programs on campus, where they will acquire an extensive knowledge of molecular biology, genetics of model systems, and human genetics. The introductory course in Human Genetics and three advanced genetics seminars are required, as well as basic graduate courses in Molecular Biology, Fundamentals of Genetics, Biochemistry and Cell Biology. We believe that the time spent in formal course work, although significant in the first year and a half of the program, provides our students with an excellent, broad-based foundation for careers in biomedical research.
Listed in blue boxes are those courses that are shared with other Graduate Programs in the School of Medicine. Those courses listed in a red box are specific for Human Genetics Students.
Electives available include existing courses in human biology as well as those in genetics and molecular biology. In addition, there are many other courses available in the Schools of Medicine, School of Public Health and at Homewood which may be appropriate for individualized programs. These include courses in Bioinformatics, Advanced Biostatistics and many other subject-related topics.
Research training begins soon after the student enters the program. The rotation electives are selected by the student according to his/her interests. A series of informal luncheon meetings with the faculty as well as the Human Genetics Student/Faculty retreat, held in September each year, provides the student with an opportunity to become acquainted with the research activities of each of the preceptors.
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Eczema | University of Maryland Medical Center
Posted: at 2:42 pm
Introduction
Eczema is a chronic, inflammatory skin disorder. It can appear as blisters that crust over to become scaly, itchy rashes, or as dry, thick patches of skin with scales. The main symptom is itching, and symptoms can come and go. Although eczema is not contagious, it is very common. People with eczema often have a personal or family history of allergies. There is no cure, however, treatments can reduce symptoms and help prevent outbreaks.
The most common signs of eczema are:
Eczema in children under 2 years old generally starts on the cheeks, elbows, or knees. In adults, it tends to be found on the inside surfaces of the knees and elbows.
Researchers do notknow for sure what causes eczema. It may be a combination of hereditary (genetic) and environmental factors. In some people, allergies may trigger eczema. Exposure to certain irritants and allergens can make symptoms worse, as can dry skin, exposure to water, temperature changes, and stress.
Stress can make eczema worse. Other irritants that can make eczema worse include:
Wool or synthetic fibers
Certain soaps and detergents, as well as perfumes and some cosmetics
Dust or sand
Cigarette smoke
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Treatment of Vaginal Eczema – Dermatology – MedHelp
Posted: at 2:42 pm
Due to no health insurance, I am self-diagnosed with vaginal eczema. I have had eczema all over my body since the day I was born, but as I aged the symptoms lessened to the point that I rarely ever have any spots--except on my vaginal area, which has been tormenting me for about 20 years now.
About 15 years ago, my mother mentioned to me that a lot of people with eczema have allergy to aloe.I experimented with aloe & found out that FOR SURE I was one of them aloe-intolerant people.And it doesn't surprise me that I only had vaginal irritation for the last TWO decades, & not my whole life (I am now 40) because it's been only within the last 20 years that aloe has become a staple in almost EVERY beauty product.
I am sharing this with you all--a bit late, but hopefully someone who is browsing the web for a solution to the same problem can benefit from this.
Now I want to list some of the items that aloe is in, as I myself was amazed at my finding while trying to weed out aloe in my hygiene: Some bathroom tissue--toilet paper--has aloe.It may not say it on the package, but I recommend calling the customer service hotline to make sure yours doesn't.It's added to give the tissue softness. Almost every triple-blade & quadruple blade razor.It's in the moisture strip.Dollar Shave Club has a triple blade that doesn't have aloe.I only use their blades now. Hair gel, styling mouse, lotion, shampoo, conditioner, soap. Some girdles--believe it or not, some girdle makers CLAIM the aloe helps you lose fat while wearing it. Condoms--yes, some condoms even use aloe in the lubricants. Baby wipes. Shaving gel. I'll tell you the pain I've had for the last 11 years trying to get my partner to quit using his Aveeno aloe & flaxseed hair gel & to quit using them Bic blades with aloe.It has made my sex life absolute HADES b/c with all the aloe he was using on his body was causing severe irritation on my labia. He's finally weeded out the aloe, but only because *I* went out & bought him all theshaving supplies, hair supplies & paid for the monthly order from Dollar Shave Club. I'm telling you, you will come across 3 types of partners: 1. Those who don't care 2.Those who think you're making more out of it than what it is. 3.Those who think you're lying about the problem.
You have to stand alone on this & do what you can to promote your own sexual health--because apparently no one else will care.
Also, I want to say that the only thing that's helped me is Lysine Plus cream--meant for the lips on the face, not the vaginal ones--from Quantum Inc.Just dab lightly with it, it's way too expensive to apply liberally.
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Treatment of Vaginal Eczema - Dermatology - MedHelp
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Dyshidrotic Eczema Pictures, Causes, Home Remedies …
Posted: at 2:42 pm
What is Dyshidrotic Eczema?
This is a skin problem which is also known as dyshidrosis, or pompholyx. This skin condition creates fluid-filled, small blisters or vesicles on the soles of the feet or palms of the hands or both.
These blisters occurring in dyshidrotic eczema normally last around 3 weeks and causes extreme itching. When these blisters dry, cracks and groves or fissures develop, which are very painful.
Management for dyshidrotic eczema most often requires topical creams, ultraviolet light or wet compresses to improve the appearance as well as ease symptoms.
The cause of dyshidrotic eczema is not known. But, it can be linked with a similar disorder of the skin known as atopic dermatitis as well as allergic conditions, for instance asthma and hay fever known as allergic rhinitis. Eruptions can be seasonal in individuals with allergies.
With dyshidrotic eczema, the affected areas of the skin come to be inflamed. Because of this, the connections between the cells of the skin open and this allows fluid or serum to seal these spaces. Physicians denote this development as spongiosis since when viewed under microscope; the skin appears sponge-like with these numerous fluid-filled spaces.
Signs or symptoms of dyshidrotic eczema include:
Risk aspects for dyshidrotic eczema include:
Females seem to have this condition more than men
Appear to be more frequent during stressful times
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How to Treat Nail Eczema (6 Steps) | eHow
Posted: at 2:42 pm
Eczema is a type of atopic dermatitis that results in red, irritated skin that may ooze and crust over causing the skin to appear scaly, according to the Australasian College of Dermatologists. Eczema of the fingernails occurs under and around the nail beds and occurs when the skin becomes irritated or is exposed to chronic moisture, such as when a child repeatedly sucks his thumb. There are several ways to treat nail eczema to clear up the unwanted redness and irritation.
Moisturizing lotion
Cold compress
Avoid over-exposure to water. This means staying out of the pool for extended periods of time and wearing rubber gloves when cleaning and doing the dishes. This will cut down on the dryness that will make nail eczema worse.
Apply moisturizing lotion to the nail beds at least once a day. This will keep the skin supple and can be used to treat eczema all over your body to help seal in moisture.
Identify what triggers your eczema and attempt to avoid it. According to Mayo Clinic.com, common eczema triggers include stress, contact with certain household cleaners, sweating and harsh soaps and perfumes.
Place a cold compress on the affected finger or toe nails when a flare-up is occurring. This could include a bag of peas wrapped in a hand towel or an ice pack. This will relieve the irritation, redness and swelling that is associated with eczema.
Cover the nails with a one percent hydrocortisone cream. This will help relieve any itching that might accompany eczema.
Speak to your doctor about any medications that will help treat the symptoms of nail eczema. These include immunomodulators that, according to the Mayo Clinic, will lessen the effects the immune system has on eczema. Another medication that may be prescribed is prednisone, which is a steroid that will reduce the inflammation of eczema.
Eczema and psoriasis are often mistaken for each other because they tend to share similar symptoms. ... Nail changes do occur with...
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How to Treat Nail Eczema (6 Steps) | eHow
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Atopic Eczema: What climate is best, dry or humid …
Posted: at 2:42 pm
I have a three year old son who has recently showed signs of becoming sensitized, to possibly everything. He has been diagnosed with ATOPIC ECZEMA. I have been researching all over, I understand there is some questions between dermatologists and allergists on what the cause for such a severe condition could be. Me his mother, being the genetic donor of such a horrible affliction, knows the condition first hand.
I strongly believe this condition has several parts to it. One being an immune issue, the second being allergies, and the third part extremely dry and sensitive skin. So with a sliver of knowledge, I am taking aim to improve his condition without the use of the enormous amount of drugs dermatologists have prescribed him at 3 years old. We are working closely with a wonderful allergist who has the patience and knowledge to deal with my family. My question is we now live in Albuquerque, NM. He has been through two RAST tests (blood tests to check for IgE levels), and a patch test which had no results for us to read. He, according to the RAST test has low and moderate levels to most allergic foods (wheat, dairy, corn, soy, eggs, and peanuts), he also shows a low moderate to dogs and elm.
At this point I have not noticed hay fever symptoms for our dogs we have, but with this new information from the blood tests, the dogs and his reactions to them are under my careful observation. He is on a very restricted diet and his skin is clearing with out the prescribed drugs. We will begin introducing one food at a time very soon to see the effects.
So sorry about the long preface to my question. We live in Abq., and have an opportunity to move to Fort Smith Arkansas. With the knowledge he has the possibility for his allergies to get worse (sensitized), which climate would be more likely to exascerbate his condition, the dry and very pollen filled Abq., or Arkansas a humid climate I know very little about? Kendra, Albuquerque, NM
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Gene therapy and regenerative medicine lend hope to …
Posted: at 2:41 pm
Volume 9, Issue 2 Summary
In patients with type 1 diabetes, pancreatic beta cells self-destruct, leaving the body bereft of insulin. Yasuhiro Ikeda, D.V.M., Ph.D., is working to create a customizable gene and stem cell therapy system that will arrest the loss of these beta cells possibly permanently eliminating the need for insulin injections.
Yasuhiro Ikeda, D.V.M., Ph.D., is spearheading stem cell research in the Mayo Clinic Center for Regenerative Medicine.
Nearly everyone knows someone with diabetes it's hard not to. In the United States, 1 in 3 adults and 1 in 6 children have high blood sugar, according to the National Institutes of Health.
After you eat, glucose is absorbed into your bloodstream and carried throughout your body. Insulin a hormone made by beta cells in your pancreas then signals your cells to take up glucose, helping your body turn the food into energy.
With diabetes, this process can go wrong in two basic ways:Type 1 diabetes results from the body's failure to produce insulin;type 2 diabetes occurs when there's plenty of insulin but the cells lose their ability to perceive its signal. In both cases, cells starve.
Living well with diabetes requires a lifelong commitment to monitoring blood sugar, eating properly, exercising regularly and maintaining a healthy weight. People with type 1 diabetes must also rely on insulin replacement therapy, usually through insulin injections. People with type 2 diabetes might need oral medication.
Still, every year, diabetes kills about 70,000 people in the United States and is a contributing cause in another 160,000 deaths each year, according to the Centers for Disease Control and Prevention.
Yasuhiro Ikeda, D.V.M., Ph.D., a molecular biologist at Mayo Clinic in Rochester, Minn., wants to change that.
After beginning his career as a veterinary feline specialist, Dr. Ikeda had to change course when he developed an allergy to his four-legged patients that made it impossible to be in a room with them. He turned his attention toward research and discovered that his interest in molecular virology had human as well as feline applications.
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An Introduction to Molecular Medicine and Gene Therapy …
Posted: at 2:41 pm
Gene therapy, or the use of genetic manipulation for disease treatment, is derived from advances in genetics, molecular biology, clinical medicine, and human genomics. Molecular medicine, the application of molecular biological techniques to disease treatment and diagnosis, is derived from the development of human organ transplantation, pharmacotherapy, and elucidation of the human genome. An Introduction to Molecular Medicine and Gene Therapy provides a basis for interpreting new clinical and basic research findings in the areas of cloning, gene transfer, and targeting; the applications of genetic medicine to clinical conditions; ethics and governmental regulations; and the burgeoning fields of genomics, biotechnology, and bioinformatics. By dividing the material into three sections - an introduction to basic science, a review of clinical applications, and a discussion of the evolving issues related to gene therapy and molecular medicine-this comprehensive manual describes the basic approaches to the broad range of actual and potential genetic-based therapies.
In addition, An Introduction to Molecular Medicine and Gene Therapy:
This textbook offers a clear, concise writing style, drawing upon the expertise of the authors, all renowned researchers in their respective specialties of molecular medicine. Researchers in genetics and molecular medicine will all find An Introduction to Molecular Medicine and Gene Therapy to be an essential guide to the rapidly evolving field of gene therapy and its applications in molecular medicine.
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An Introduction to Molecular Medicine and Gene Therapy ...
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Libertarianism – RationalWiki
Posted: at 2:41 pm
Libertarians secretly worried that ultimately someone will figure out the whole of their political philosophy boils down to 'get off my property.' News flash: This is not really a big secret to the rest of us.
Libertarianism is, at its simplest, the antonym of authoritarianism.[2] The term has been around since the beginning of the 20th century or earlier and was primarily used for self-identification with anarcho-syndicalism and labor movements. In the USA, the term was adopted by the Foundation for Economic Education think tank in the 1950's[3] to describe a political and social philosophy that advocates laissez-faire capitalism as a panacea for virtually everything. Non-libertarians view this as synonymous with oligarchic plutocracy after the fashion of the American Gilded Age, while the reality-based community tends to realize that one cannot just yank economic theories out of the air and magically expect them to work.
This anti-government phenomenon is found primarily in the United States, likely due to Americans' extensive experience with dysfunctional government, coupled with their unawareness of the existence of other countries. Historically, and almost everywhere other than America still today, the term has been associated with libertarian socialism and anarchism. The adoption of the libertarian label by advocates of free market economics is an ironic example of their tendency to take credit for other people's ideas.
The US political party most aligned with libertarianism is the Libertarian Party, "America's Third Largest Party,"[4] whose candidate obtained 1.3 million, or 0.99% of the popular vote in the 2012 Presidential election.[5] This, compared to 0.32% of the popular vote[6] in the 2004 Presidential election, was considered by many libertarians to be "an improvement."
There is also an "Objectivist Party," formed as a spin-off from the Libertarian Party by those who thought that the party's 2008 presidential candidate, Bob Barr, was too left-wing,[7] and a Boston Tea Party (no connection other than ideological to that other tea party) formed as a spin-off by those who thought the Libertarian Party had become too right-wing on foreign policy and civil liberties after the LP deleted much of its platform in 2006.
Basically everyone agrees with libertarians on something, but they tend to get freaked out just as quickly by the ideologys other stances.
The dominant form of libertarianism (as found in the US) is an ideology based largely on Austrian school economics, which relies on axioms, rather than empirical analysis to inform economic and social policy. That said, the branch of libertarianism that has had the most success in influencing public policy is primarily informed by the Chicago school.
Proponents of libertarianism frequently cite the "Non-Aggression Principle" (NAP) as the moral basis of their ideology. The NAP states that everyone is free to do whatever they want with their lives and property, so long as it does not directly interfere with the freedom of others to do the same. Under this rule, you may only use "force" in response to prior inappropriate force against the life and/or property of yourself or others. Compare and contrast with John Stuart Mill's "The Harm Principle." The critical difference between the two is that libertarians completely oppose the preemptive use of force. By contrast, Mill and other classical liberals believe that the preemptive use of force to prevent likely future harm can be justified.
Under any logical scrutiny it becomes evident that the precise definition of aggression is highly subjective and supposes a strict libertarian definition of property.[11] The NAP can therefore be used in almost any way its user intends, by changing the definition of aggression to suit their particular opinion/agenda. For example, throwing someone in prison for massive tax evasion is seen as an act of aggression by the state, whereas selling someone cigarettes knowing they will kill them is not seen as aggression.
Libertarians frequently oppose taxation (as taxes are "theft of property by force") for anything aside from a small wish list that libertarians like. The main exceptions are civil courts to handle contract disputes (including fraud) and to handle suits of harm (such as dumping of hazardous chemicals on your land; as opposed to dumping hazardous chemicals on public land, which isn't an issue for libertarians), criminal courts, police, and an army. As one moves down the ideological spectrum towards the extremes, more and more things normally handled by the police and criminal courts are instead handled by civil courts, and eventually even the civil courts are privatized, i.e., anarcho-capitalism. Government, libertarians believe, is the biggest (and possibly the only) threat to freedom.
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New Kind of Mind: The Difference Between Libertarianism …
Posted: at 2:41 pm
I typically describe myself as a libertarian anarchist. People who dont understand what either word means will essentially assume that Im doubly insane. Libertarian is a more friendly word; anarchist is generally perceived to be hostile. Libertarians are usually considered fringe; anarchists are usually considered dangerous. Yet some people, especially people who are libertarian or anarchists, view the words as essentially the same thing. Analytically speaking, it seems there should be a distinction even if the situation likens itself in many cases to a square being a rectangle, but rectangle not necessarily being a square.
Libertarianism is an ethical doctrine. It is concerned with rights. Most commonly this right is referred to as the right to self ownership which includes the right to the product of your labor. For some (probably most) libertarians, this is essentially a faith based, though not necessarily theological, concept. It is taken on faith that men are imbued with this right through nature or that that these rights are implied by the nature of truth, knowledge, existence, reason, etc. What is ironic about this faith based libertarian concept is that it is widely accepted on face value by most participants in modern (classical) liberal societies. It is conservative (not as in American Conservatives, but as in historically organized society) culture that refutes the idea of self ownership by subjecting the behavior of the individual to the enforced law of the moral majority. However, the concept of self ownership is thoroughly ignored by most in society even while they champion it as the bedrock of their modern culture of tolerance. This is because most of society is conservative and Rightist as opposed to liberal and Leftist. This betrayal of self ownership is implied by the aggression of the government that is condoned by the populace. Even commonplace policy positions in support of a state single payer health care system or a central bank or drug prohibition demonstrate the contempt the populace shows to the individual who libertarians argue should hold sole dominion over his own life. The popular opinion demonstrates a fondness for collective ownership of individuals - a collective slavery, if you will - that the scope of control over humanity extends past ones own fingertips to some degree.
The other form of libertarianism holds that libertarianism is a desirable ethical standard because it results in the most beneficial outcomes. Consequentialists do not operate on faithful assumptions about the nature and rights of men. Their considerations are directed towards a scientific standard that observes and deduces that greater degrees of self ownership and liberty result in a flourishing of society in terms of wealth and culture. While not completely comfortable throwing myself into either category (since I do believe in Divinely granted human rights to self ownership), I probably fit best in the consequentialist camp.
The libertarian principle of non-aggression simply is a means of asserting the premise of self ownership. The non-aggression principle states that one may/should not use coercive physical force to violate the self ownership of any other person. The principle clearly understood merely asserts that all actions should be voluntarily untaken. Likewise, toleration is a key characteristic of libertarian ethics. Libertarians are not required to approve of the actions of others, but, so long as those actions are non-coercive, persuasion is the only ethical outlet for change. The use of force is illegitimate for libertarians. Only the initiation of such force justifies the use of force and only as retaliation. What is clear is that libertarians oppose government. Government is any actor, individual, or collective that negates the liberty of self ownership - any entity that claims control over another person or persons. Libertarians generally concede the necessity of institutions that may seek to prevent violations of liberty in advance through the use of defensive tactics. The purest and most cogent form of libertarianism is anarchistic because the existence of a State requires the involuntary submission to pay for the monopoly services of that State, an obvious violation of liberty.
Anarchism has nothing to do with rights or ethics. The concept of philosophical anarchism may, but that is very similar if not the same as libertarianism. Anarchism is a political concept that promotes ideas hostile to the State. The State can essentially be viewed as a self enforcing monopoly with power over a specified although possibly indefinite region. Because governing institutions are most effective at depriving individuals of liberty, they are well equipped to claim dominion over and submission to itself, while aiming to protect itself from competition. The most effective tool at the disposal of a State or a government that wishes to obtain or maintain Statehood is propaganda which to reinforce its Laws through pop justification. Statist institutions maintain their monopoly through force and through the repeated demonization of competing government and defensive services. Usually, States will seek to expand their role from just that of a governing body to one of greater scope ie education, health care, postal services, etc. States are emblematic and self-reinforced by their governing AND governed classes. In monarchy, a single person is put in charge of the lawmaking process. In oligarchy, a few people decide the laws. In aristocracy, the wealthy decide the laws. In a democracy, the law is decided by the majority of people. Anarchism is opposition to all of this. Fundamentally, anarchism is a strain of political anti-authoritarianism that regards the authority of the State governing class as illegitimate. Anarchists seek the abolition of the political State and its resultant law in lieu of a new order of organic law.
The confusion between anarchy and chaos is fair to a degree. With the abolition of the State, the law would be the natural outcome of community, market, and physical dominance. However, this does not distinguish it from the State at all. The society that approves the will of the State determines the legitimate scope of the State. Furthermore, the rule of the State is enforced strictly through physical dominance. In an anarchist society, one could act anti-socially to any degree he pleases and can get away with, but it is unlikely in civil society that he would last very long. The fear that these people would run rampant is unwarranted. The benefits of cooperation discourage anti-social behavior. The cooperative aspects of society have been learned and evolved into to deal with anti-social behavior. So, any man exposing the world to tyranny would not likely have long before voluntary and contractual coalitions of people were to fight back. Even if this were not the case, the pro-State assumption that anti-social, and in this sense I mean both malevolent and incompetent, people will not infiltrate the State apparatus is false. In fact, the opposite is true. The State apparatus, not existing on a competitive level to help ensure quality and customer satisfaction, involves the gradual usurpation of power by the anti-social (of course assuming the originators of the State were not themselves anti-social). The cohesive force in anarchist society is contract and cooperation for mutual benefit. In other words, anarchist society promotes the thriving of the market by leveling the playing field, increasing transparency, and reflecting the demands of society over State.
An interesting way to view the anarchist struggle is to envision a society of political ladders of power. Statist leaders attempt to climb these ladders to gain power and oversight. Anarchists shake the ladders and expose as phony the pretense under which Statists argue they had a right to become lawmakers instead of market participants in the first place. As the evolution of Statism takes hold and the justifications for it become more broad, the privilege of Statism extends to a larger base of people, starting as monarchist and culminating in democratic. Anarchists are there the entire time to shake the ladders and challenge the idea there should be ladders at all.
In summation, libertarians promote voluntary human interactions as morally imperative or advantageous. Anarchists oppose others holding dominion over them. Libertarianism is the liberation of all individuals from the authority of society. Anarchism is the liberation of self from (political) authority. A (pure) libertarian is an anarchist, but an anarchist is not necessarily a libertarian.
Next Up: Why I Am First and Foremost an Anarchist and Less of a Libertarian
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